Journal articles: 'Mucosa Orale'

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Attuati, Sara, Valeria Martini, Riccardo Mauro Bonacina, and Umberto Mariani. "Neoformazione ulcerata della mucosa orale." Dental Cadmos 87, no. 04 (April 2019): 197. http://dx.doi.org/10.19256/d.cadmos.04.2019.03.

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Di Iorio, E. "Lesione esofitica della mucosa orale." Dental Cadmos 85, no. 06 (June 2017): 327. http://dx.doi.org/10.19256/d.cadmos.06.2017.04.

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Beauvillain de Montreuil, C., M. H. Tessier, and J. Billet. "Patologia benigna della mucosa orale." EMC - Otorinolaringoiatria 11, no. 3 (September 2012): 1–20. http://dx.doi.org/10.1016/s1639-870x(12)62051-0.

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Beauvillain de Montreuil, C., M. H. Tessier, and J. Billet. "Patologia benigna della mucosa orale." EMC - Otorinolaringoiatria 18, no. 2 (June 2019): 1–23. http://dx.doi.org/10.1016/s1639-870x(19)42040-0.

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Di lorio, E. "Pigmentazioni multiple della mucosa orale." Dental Cadmos 83, no. 7 (September 2015): 443–44. http://dx.doi.org/10.1016/s0011-8524(15)30062-3.

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Baart, J. A. "Oral medicine 6. Ulceraties van de orale mucosa." Nederlands Tijdschrift voor Tandheelkunde 120, no. 05 (May 10, 2013): 246–49. http://dx.doi.org/10.5177/ntvt.2013.05.12242.

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Grande, Francesco, and Claudio Marchetti. "Bolle ematiche ricorrenti sulla mucosa orale." Dental Cadmos 87, no. 01 (September 2019): 541. http://dx.doi.org/10.19256/d.cadmos.09.2019.03.

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MORO, A., C. DE WAURE, F. DI NARDO, F. SPADARI, M. D. MIGNOGNA, M. GIULIANI, L. CALIFANO, et al. "Il dispositivo medico GOCCLES® è in grado di individuare displasie e cancro orale se impiegato nel setting odontoiatrico. Risultati da uno studio multicentrico." Acta Otorhinolaryngologica Italica 35, no. 6 (December 2015): 449–54. http://dx.doi.org/10.14639/0392-100x-922.

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Scopo di questo studio è dimostrare che il dispositivo medico GOCCLES® permette di condurre l’esame dell’autofluorescenza del cavo orale nel setting odontoiatrico. Si tratta di uno studio multicentrico non randomizzato su pazienti consecutivi a rischio di cancro orale. I pazienti sono stati sottoposti ad ispezione del cavo orale ad occhio nudo seguita dall’esame dell’autofluorescenza condotto indossando gli occhiali GOCCLES® mentre una lampada fotopolimerizzante illuminava la mucosa orale. Le lesioni sono state definite come qualunque lesione precancerosa del cavo orale visibile ad occhio nudo o area di perdita di fluorescenza visibile con GOCCLES®. Tutte le lesioni persistenti sono state sottoposte a biopsia escissionale o incisionale. Sono stati reclutati 61 pazienti e analizzati i dati da 64 lesioni. Delle 62 lesioni identificate dal dispositivo, 31 erano veramente positive. Il dispositivo ha identificato 31 delle 32 lesioni veramente positive. Una lesione (un carcinoma invasivo) non era visibile ad occhio nudo. Tutte le lesioni classificate come displasia tra moderata e severa e ogni carcinoma sono stati correttamente identificati dal dispositivo. Nel Il 56,7% delle lesioni identificate dal dispositivo mostrava margini più ampi rispetto a quelli visibili ad occhio nudo. Il dispositivo medico GOCCLES® permette di osservare il fenomeno della perdita di fluorescenza in pazienti affetti da displasia o cancro del cavo orale. Ha permesso di effettuare l’esame dell’autofluorescenza con ciascuna lampada fotopolimerizzante testata. I risultati suggeriscono di impiegare GOCCLES® come esame complementare rispetto all’ispezione ad occhio nudo del cavo orale su pazienti a rischio per cancro orale. Il dispositivo permette di identificare lesioni altrimenti visibili o i cui margini sono sottostimati dall’ispezione ad occhio nudo.

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Rooijers, W. "Medicaments and oral healthcare. Adverse effects of medications on the oral mucosa." Nederlands Tijdschrift voor Tandheelkunde 127, no. 07/08 (July 3, 2020): 434–40. http://dx.doi.org/10.5177/ntvt.2020.07/08.20007.

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Meleti, M., B. Bianchi, E. Merigo, M. Manfredi, R. Guidotti, C. Fornaini, A. Sarraj, G. Mergoni, L. Corcione, and P. Vescovi. "Pigmentazioni maculari acquisite delle labbra e della mucosa orale." Dental Cadmos 79, no. 2 (February 2011): 59–60. http://dx.doi.org/10.1016/j.cadmos.2010.11.001.

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Vescovi, P., M. Manfredi, M. Meleti, E. Merigo, R. Guidotti, A. Sarraj, G. Mergoni, C. Fornaini, T. Simonazzi, and M. Bonanini. "Lesioni bianche bilaterali della mucosa orale e della lingua." Dental Cadmos 81, no. 1 (January 2013): 3–4. http://dx.doi.org/10.1016/s0011-8524(13)70006-0.

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Merigo, E., C. Fornaini, M. Manfredi, M. Meleti, R. Guidotti, A. Sarraj, G. Mergoni, T. Simonazzi, M. Bonanini, and P. Vescovi. "Lesioni ulcerative bilaterali della mucosa orale e della lingua." Dental Cadmos 81, no. 3 (March 2013): 115–16. http://dx.doi.org/10.1016/s0011-8524(13)70027-8.

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Di Iorio, E. "Lesioni vescicolo-erosive della mucosa orale in paziente totalmente edentula." Dental Cadmos 82, no. 8 (October 2014): 535–36. http://dx.doi.org/10.1016/s0011-8524(14)70215-6.

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Di Iorio, E. "Lesioni rosse multiple della mucosa orale in paziente parzialmente edentula." Dental Cadmos 83, no. 1 (January 2015): 7–8. http://dx.doi.org/10.1016/s0011-8524(15)70256-4.

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Sarraj, A., G. Mergoni, M. Manfredi, E. Merigo, M. Meleti, T. Simonazzi, I. Giovannacci, E. Silini, and P. Vescovi. "Placche ed erosioni della mucosa orale associate a disturbi intestinali." Dental Cadmos 83, no. 2 (February 2015): 67–68. http://dx.doi.org/10.1016/s0011-8524(15)70268-0.

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Asikainen, P. J. "A phd completed. The effect of radiotherapy on oral mucosa cell morphology." Nederlands Tijdschrift voor Tandheelkunde 125, no. 03 (March 2, 2018): 169–71. http://dx.doi.org/10.5177/ntvt.2018.03.17229.

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Cotellessa, S., G. Fantozzi, F. Donnini, and G. M. Nardi. "L’utilizzo della fertomcidina U in alcuni casi di patologia della mucosa orale." Prevenzione & Assistenza Dentale 35, no. 2 (April 2009): 77–82. http://dx.doi.org/10.1016/j.pad.2007.07.001.

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Ardore, M., G. Tempia Valenta, M. Pentenero, and S. Gandolfo. "Utilizzo del test VELscope nella valutazione delle lesioni oncologicamente sospette della mucosa orale." Dental Cadmos 80, no. 9 (November 2012): 538–46. http://dx.doi.org/10.1016/j.cadmos.2012.05.001.

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Yoruk, O., A. Tatar, O. N. Keles, and A. Cakir. "The value of Nigella sativa in the treatment of experimentally induced rhinosinusitis." Acta Otorhinolaryngologica Italica 37, no. 1 (February 2017): 32–37. http://dx.doi.org/10.14639/0392-100x-1143.

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Obiettivo del presente studio è stato quello di investigare leffetto della Nigella sativa e della cefalexina nel trattamento della rinosinusite batterica indotta in setting sperimentale. La rinosinusite batterica è stata indotta mediante stafilococco aureo. I conigli sono stati suddivisi in 5 gruppi; uno di controllo (n = 6), N. sativa 50 mg/kg/d (n = 6), N. sativa 100 mg/kg/d (n = 6), N. sativa 200 mg/kg/d (n = 6), e cefalexina 20 mg/kg/d (n = 6). La N. sativa è stata somministrata per via orale per 7 giorni. Lo stesso volume di soluzione salina (% 0,9 NaCl) è stato quindi somministrato al gruppo di controllo per lo stesso periodo di tempo. Dopo il periodo di trattamento i campioni di mucosa dei seni mascellari sono stati valutati utilizzando metodologie istopatologiche e stereologiche. La metà dei campioni di mucosa del seno mascellare sono stati congelati a -80°C per una successiva analisi dei livelli di ossido nitrico. Lanalisi patologica ha rivelato un intenso processo infiammatorio in atto nei conigli trattati con sola soluzione salina. Solo un lieve grado di infiammazione è stato invece rilevato nei conigli nei gruppi trattati con cefalexina, N. sativa 100 mg/kg/d, e N. sativa 200 mg/kg/d. Il livello di ossido nitrico, elevato nel gruppo placebo, è risultato invece essere ridotto negli altri gruppi. La N. sativa potrebbe prevenire i ambiamenti istopatologici indotti dalla rinosinusite mediante una riduzione dei livelli di ossido nitrico con andamento dose dipendente, e potrebbe essere usata nel trattamento della rinosinusite.

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Diaz, Patricia I., Zhihong Xie, Takanori Sobue, Angela Thompson, Basak Biyikoglu, Austin Ricker, Laertis Ikonomou, and Anna Dongari-Bagtzoglou. "Synergistic Interaction between Candida albicans and Commensal Oral Streptococci in a NovelIn VitroMucosal Model." Infection and Immunity 80, no. 2 (November 21, 2011): 620–32. http://dx.doi.org/10.1128/iai.05896-11.

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ABSTRACTCandida albicansis a commensal colonizer of the gastrointestinal tract of humans, where it coexists with highly diverse bacterial communities. It is not clear whether this interaction limits or promotes the potential ofC. albicansto become an opportunistic pathogen. Here we investigate the interaction betweenC. albicansand three species of streptococci from the viridans group, which are ubiquitous and abundant oral commensal bacteria. The ability ofC. albicansto form biofilms withStreptococcus oralis,Streptococcus sanguinis, orStreptococcus gordoniiwas investigated using flow cell devices that allow abiotic biofilm formation under salivary flow. In addition, we designed a novel flow cell system that allows mucosal biofilm formation under conditions that mimic the environment in the oral and esophageal mucosae. It was observed thatC. albicansand streptococci formed a synergistic partnership whereC. albicanspromoted the ability of streptococci to form biofilms on abiotic surfaces or on the surface of an oral mucosa analogue. The increased ability of streptococci to form biofilms in the presence ofC. albicanscould not be explained by a growth-stimulatory effect since the streptococci were unaffected in their growth in planktonic coculture withC. albicans. Conversely, the presence of streptococci increased the ability ofC. albicansto invade organotypic models of the oral and esophageal mucosae under conditions of salivary flow. Moreover, characterization of mucosal invasion by the biofilm microorganisms suggested that the esophageal mucosa is more permissive to invasion than the oral mucosa. In summary,C. albicansand commensal oral streptococci display a synergistic interaction with implications for the pathogenic potential ofC. albicansin the upper gastrointestinal tract.

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Adibrad, Mehdi, Mohammad Shahabuei, and Mahasti Sahabi. "Significance of the Width of Keratinized Mucosa on the Health Status of the Supporting Tissue Around Implants Supporting Overdentures." Journal of Oral Implantology 35, no. 5 (October 1, 2009): 232–37. http://dx.doi.org/10.1563/aaid-joi-d-09-00035.1.

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Abstract Our objective was to determine the association between keratinized mucosa width and the health status of the supporting tissue around implants supporting overdentures. Sixty-six functioning dental implants were examined. Periodontal parameters measured included gingival index, plaque index, bleeding on probing, probing depth, mucosal recession, periodontal attachment level, radiographic bone level, and width of keratinized mucosa. A negative correlation was found between keratinized mucosa width and mucosal recession and periodontal attachment level. When data were dichotomized by keratinized mucosa width, the mean gingival index score, plaque index score, and bleeding on probing were significantly higher for those implants with a narrow zone (<2 mm) of keratinized mucosa. A wider mucosal band (≥2 mm) was associated with less mucosal recession and periodontal attachment loss compared with a narrow (<2 mm) band. The absence of adequate keratinized mucosa around implants supporting overdentures was associated with higher plaque accumulation, gingival inflammation, bleeding on probing, and mucosal recession.

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Lü, F. X., and R. S. Jacobson. "Oral Mucosal Immunity and HIV/SIV Infection." Journal of Dental Research 86, no. 3 (March 2007): 216–26. http://dx.doi.org/10.1177/154405910708600305.

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Human Immunodeficiency Virus (HIV) transmission through genital and rectal mucosa has led to intensive study of mucosal immune responses to HIV and to the development of a vaccine administered locally. However, HIV transmission through the oral mucosa is a rare event. The oral mucosa represents a physical barrier and contains immunological elements to prevent the invasion of pathogenic organisms. This particular defense differs between micro-compartments represented by the salivary glands, oral mucosa, and palatine tonsils. Secretory immunity of the salivary glands, unique features of cellular structure in the oral mucosa and palatine tonsils, the high rate of oral blood flow, and innate factors in saliva may all contribute to the resistance to HIV/Simian Immunodeficiency Virus (SIV) oral mucosal infection. In the early stage of HIV infection, humoral and cellular immunity and innate immune functions in oral mucosa are maintained. However, these particular immune responses may all be impaired as a result of chronic HIV infection. A better understanding of oral mucosal immune mechanisms should lead to improved prevention of viral and bacterial infections, particularly in immunocompromised persons with Acquired Immune Deficiency Syndrome (AIDS), and to the development of a novel strategy for a mucosal AIDS vaccine, as well as vaccines to combat other oral diseases, such as dental caries and periodontal diseases.

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Medina, Marcelo Gabriel, Karina Marinic, Myriam Lucrecia Medina, Alicia Sorrentino, Manuel Fernando Giménez, and Luis Antonio Merino. "Detección de papilomavirus humano en mucosa oral en hombres con verrugas anogenitales." Memorias del Instituto de Investigaciones en Ciencias de la Salud 19, no. 2 (August 1, 2021): 41–48. http://dx.doi.org/10.18004/mem.iics/1812-9528/2021.019.02.41.

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El virus del papiloma humano (HPV) es el agente etiológico de infecciones de transmisión sexual relacionadas con procesos oncogénicos genitales y orales. La biología molecular, mediante la identificación de los tipos virales involucrados, proporciona precisión diagnóstica con un enfoque epidemiológico. El objetivo de este estudio fue determinar la presencia de HPV en la mucosa oral de hombres con verrugas anogenitales y correlacionar los genotipos detectados en ambas muestras. Se estudiaron 26 pacientes varones con verrugas anogenitales que acudieron al Instituto de Dermatología de la ciudad de Resistencia (Argentina). La presencia de HPV en muestras orales y anogenitales se estudió mediante reacción en cadena de la polimerasa (PCR) y la genotipificación se realizó mediante PCR-RFLP. La prevalencia de HPV oral en pacientes con HPV anogenital fue del 46,2% (12/26). Se encontraron dieciocho genotipos con alto riesgo oncogénico en muestras orales de pacientes con infecciones únicas o múltiples y el tipo 16 fue el más frecuente (6 pacientes). Catorce genotipos en muestras orales fueron de bajo riesgo oncogénico, el más frecuente fue el tipo 6 (10 pacientes). En muestras anogenitales el genotipo 6 fue el más frecuente (13 pacientes), solo o en coinfección. Se encontró una alta prevalencia de HPV oral de malignidad de alto grado en nuestra población y coinfección con tipos oncogénicos. Las prácticas de sexo oral fueron la principal conducta de riesgo para la infección, lo que quedó demostrado por el hallazgo simultáneo del mismo tipo de HPV en muestras orales y anogenitales.

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Szpaderska, A. M., J. D. Zuckerman, and L. A. DiPietro. "Differential Injury Responses in Oral Mucosal and Cutaneous Wounds." Journal of Dental Research 82, no. 8 (August 2003): 621–26. http://dx.doi.org/10.1177/154405910308200810.

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Oral mucosa heals faster than does skin, yet few studies have compared the repair at oral mucosal and cutaneous sites. To determine whether the privileged healing of oral injuries involves a differential inflammatory phase, we compared the inflammatory cell infiltrate and cytokine production in wounds of equivalent size in oral mucosa and skin. Significantly lower levels of macrophage, neutrophil, and T-cell infiltration were observed in oral vs. dermal wounds. RT-PCR analysis of inflammatory cytokine production demonstrated that oral wounds contained significantly less IL-6 and KC than did skin wounds. Similarly, the level of the pro-fibrotic cytokine TGF-b1 was lower in mucosal than in skin wounds. No significant differences between skin and mucosal wounds were observed for the expression of the anti-inflammatory cytokine IL-10 and the TGF-β1 modulators, fibromodulin and LTBP-1. These findings demonstrate that diminished inflammation is a key feature of the privileged repair of oral mucosa.

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George, Jeffy, Wendeline Wagner, Mark G. Lewis, and Joseph J. Mattapallil. "Significant Depletion of CD4+T Cells Occurs in the Oral Mucosa during Simian Immunodeficiency Virus Infection with the Infected CD4+T Cell Reservoir Continuing to Persist in the Oral Mucosa during Antiretroviral Therapy." Journal of Immunology Research 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/673815.

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Human and simian immunodeficiency virus (HIV and SIV) infections are characterized by manifestation of numerous opportunistic infections and inflammatory conditions in the oral mucosa. The loss of CD4+T cells that play a critical role in maintaining mucosal immunity likely contributes to this process. Here we show that CD4+T cells constitute a minor population of T cells in the oral mucosa and display a predominantly central memory phenotype mirroring other mucosal sites such as the rectal mucosa. Chronic SIV infection was associated with a near total depletion of CD4+T cells in the oral mucosa that appear to repopulate during antiretroviral therapy (ART). Repopulating CD4+T cells harbored a large fraction of Th17 cells suggesting that ART potentially reconstitutes oral mucosal immunity. However, a minor fraction of repopulating CD4+T cells harbored SIV DNA suggesting that the viral reservoir continues to persist in the oral mucosa during ART. Therapeutic approaches aimed at obtaining sustainable CD4+T cell repopulation in combination with strategies that can eradicate the latent viral reservoir in the oral mucosa are essential for better oral health and long-term outcome in HIV infected patients.

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Campisi, G., C. Paderni, R. Saccone, M. G. Siragusa, L. Lo Muzio, C. Tripodo, L. I. Giannola, and A. M. Florena. "Carbamazepine Transbuccal Delivery: The Histo-Morphological Features of Reconstituted Human Oral Epithelium and Buccal Porcine Mucosae in the Transmucosal Permeation." International Journal of Immunopathology and Pharmacology 21, no. 4 (October 2008): 903–10. http://dx.doi.org/10.1177/039463200802100414.

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Transbuccal drug delivery is an attractive way of administration since several well-known advantages are provided, especially with respect to peroral management. Carbamazepine (CBZ) is an anticonvulsant which is useful in controlling neuropathic pain, and it is currently administered by peroral route, although its absorption and bioavailability is limited due to various factors. The oral cavity could be an interesting site for transbuccal CBZ delivery due to two properties: slow administration of constant low drug doses and less dose-related side effects. However, in transbuccal absorption a major limitation could be the low permeability of the mucosa which results in low drug bioavailability; thus the aptitude of the drug to penetrate the buccal mucosa has to be assessed by using tissue models resembling human normal mucosa. In our experience, CBZ well permeates mucosal membranes. In order to assess the efficacy of CBZ transbuccal delivery and to verify the reliability of these tissues in permeability testing before and after the passage of CBZ, the histo-morphological features of reconstituted human oral (RHO) epithelium (E) and buccal porcine mucosae were investigated. Significant histological changes due to CBZ passage were observed both in RHO-E and porcine mucosa. The main findings detected in RHO samples were cellular swellings with a signet ring-like appearance, nuclear swelling, prominent nucleoli lined against the nuclear membrane and the presence of keratohyalin granules. The most striking finding regarding porcine buccal mucosa was a cytoplasmic vacuolization, mainly involving the basal layer.

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Chow, James C. L., and Amir M. Owrangi. "Monte Carlo study on mucosal dose in oral and naval cavity using photon beams with small field." Journal of Radiotherapy in Practice 10, no. 4 (January 11, 2011): 261–71. http://dx.doi.org/10.1017/s1460396910000427.

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AbstractWe study how mucosal dose in the oral or nasal cavity depends on the irradiated small segmental photon fields varying with beam energy, beam angle and mucosa thickness. Dose ratio (mucosal dose with bone underneath to dose at the same point without bone) reflecting the dose enhancement due to the bone backscatter was determined by Monte Carlo simulation (EGSnrc-based code), validated by measurements. Phase space files based on the 6 and 18 MV photon beams with small field size of 1 × 1 cm2, produced by a Varian 21 EX linear accelerator, were generated using the BEAMnrc Monte Carlo code. Mucosa phantoms (mucosa thickness = 1, 2 and 3 mm) with and without a bone under the mucosa were irradiated by photon beams with gantry angles varying from 0 to 30°. Doses along the central beam axis in the mucosa and the dose ratio were calculated with different mucosa thicknesses. For the 6 MV photon beams, the dose at the mucosa-bone interface increased by 44.9–41.7%, when the mucosa thickness increased from 1 to 3 mm for the beam angle ranging from 0 to 30°. These values were lower than those (58.8–53.6%) for the 18 MV photon beams with the same beam angle range. For both the 6 and 18 MV photon beams, depth doses in the mucosa were found to increase with an increase of the beam angle. Moreover, the dose gradient in the mucosa was greater for the 18 MV photon beams compared to the 6 MV. For the dose ratio, it was found that the dose enhancement due to the bone backscatter increased with a decrease of mucosa thickness, and was more significant at both the air-mucosa and mucosa-bone interface. Mucosal dose with bone was investigated by Monte Carlo simulations with different experimental configurations, and was found vary with the beam energy, beam angle and mucosa thickness for a small segmental photon field. The dosimetric information in this study should be considered when searching for an optimized treatment strategy to minimize the mucosal complications in the head-and-neck intensity-modulated radiation therapy.

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Ogata, Hisao, Tatsuo Nakajima, Fumio Onishi, Ikkei Tamada, and Makoto Hikosaka. "Cleft Palate Repair Using a Marginal Musculo-Mucosal Flap." Cleft Palate-Craniofacial Journal 43, no. 6 (November 2006): 651–55. http://dx.doi.org/10.1597/05-011.

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Objective: To describe a modified procedure consisting of a mucoso-periosteal flap palatoplasty with a marginal musculo-mucosal flap (3M flap). This is also the first report of a primary repair for complete cleft palate using the 3M flap. We describe the lengthening effect of the nasal mucous layer of the soft palate and evaluate the fistula formation rate associated with this method. Methods: This procedure has been performed on 21 patients with unilateral complete clefts and on 27 patients with incomplete clefts. A mucoso-periosteal flap raised from the hard palate was used mainly for closure of the cleft and not for the push-back. The 3M flap repaired the deficit of the nasal mucosa, making sure that the soft palate was lengthened. Intravelar veloplasty was performed also. Results: The dimension of the nasal mucosal defect that can be filled with the 3M flap is 10 to 12 mm in length, oriented anterior-posterior, and 15 to 20 mm wide. Oronasal fistula formation was recognized in only 3 of 48 cases (2 of 21 complete clefts, 1 of 27 incomplete clefts) and were located at the hard-soft palate junction at the anterior portion of the 3M flap. Conclusions: This method has the theoretical advantages of (1) preventing fistula formation by filling the tissue deficiency with the 3M flap; (2) achieving better velopharyngeal function due to elongation of the soft palate and retropulsion of the muscular bundle, utilizing the 3M flap; and (3) minimizing maxillary growth retardation by adopting a non–push-back method of hard palate repair.

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Koushk-Jalali, Bijan, Svenja Schürrle, Thomas Kuntz, Georgios Mitrakos, Christian Tigges, Frank Oellig, Andreas Hammacher, Steffi Silling, Ulrike Wieland, and Alexander Kreuter. "Plattenepithelkarzinom auf dem Boden eines oralen Lichen planus." Der Hautarzt 71, no. 12 (August 20, 2020): 1000–1006. http://dx.doi.org/10.1007/s00105-020-04669-1.

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ZusammenfassungBeim Lichen planus handelt es sich vermutlich um eine chronisch inflammatorische, immunologisch induzierte mukokutane Dermatose. Der Lichen planus mucosae manifestiert sich am häufigsten in der Mundhöhle. Diverse Triggerfaktoren wie bakterielle oder virale Infektionen, Medikamente oder physikalische Reize werden bei der Entstehung der Erkrankung diskutiert. Auch eine Assoziation mit Infektionen durch humane Papillomviren wurde beschrieben, ein kausaler Zusammenhang ist jedoch nicht hinreichend belegt. Als fakultative Präkanzerose kann sich auf dem Boden eines Lichen planus mucosae ein Plattenepithelkarzinom entwickeln, die maligne Transformationsrate ist aber gering. Das Risiko der malignen Transformation ist signifikant erhöht bei Patienten mit oralem Lichen planus, die rauchen, vermehrt Alkohol konsumieren oder an Hepatitis C erkrankt sind. Wir beschreiben 2 Patienten, bei denen sich lokal fortgeschrittene Plattenepithelkarzinome auf dem Boden eines langjährig bestehenden oralen Lichen planus entwickelten. Beide Fälle wurden erfolgreich durch radikale Tumorresektion mit anschließender Rekonstruktion und adjuvanter Radiatio/Radiochemotherapie behandelt.

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Pommer, Bernhard. "Techniques to preserve keratinized peri-implant mucosa in CT-guided oral implant surgery." Surgical Techniques Development 2, no. 1 (February 8, 2012): 7. http://dx.doi.org/10.4081/std.2012.e7.

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Guided implant dentistry using computed tomographic (CT) scans, virtual planning software and mucosa-supported surgical templates is an upcoming technology with the potential for more predictable and less invasive implant placement. While generally associated with a flapless approach, soft tissue punching and removal may not be indicated if available width of keratinized mucosa is limited prior to implant surgery. Two techniques to preserve keratinized peri-implant mucosa (Punch Reposition Technique and Topical Flap Technique) are presented and indications outlined. Appreciation of soft tissue conditions as well as functional and esthetic consequences of mucosal deficiencies (mucosal-driven approach) is recommended to supplement bone- and prosthetic-driven considerations in guided oral implant placement (Trinity Approach).

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Contaldo, Maria, Rossella Santoro, Antonio Romano, Francesca Loffredo, Dario Di Stasio, Fedora Della Vella, Michele Scivetti, Massimo Petruzzi, Rosario Serpico, and Alberta Lucchese. "Oral Manifestations in Children and Young Adults with Down Syndrome: A Systematic Review of the Literature." Applied Sciences 11, no. 12 (June 10, 2021): 5408. http://dx.doi.org/10.3390/app11125408.

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Down syndrome (DS) is an autosomal disorder associated with mental and physical involvement. The typical craniofacial phenotype and the dental anomalies in DS subjects have been widely described, but a systematic report on the manifestations affecting the oral mucosae in children with DS is still lacking. This systematic review aimed to establish the prevalence of oral mucosal manifestations in children/young adults with DS. Pubmed, Web of Science, and Scopus were investigated in September 2020. Documents in English on DS children/young adults (up to 25 years) reporting oral mucosal findings were considered. Study quality was assessed with ROBIN-I. Of the 150 references retrieved, 14 studies were considered eligible. The risk of bias ranged from low to unclear. Fissured tongue appeared to increase with age and was more prevalent in DS children than in the general population. Lip fissures and cheilitis were heterogeneously reported. Candida spp. carriage with and without active candidiasis was more frequent in DS children/young adults than in controls. C. albicans was the most prevalent species. Few other oral mucosal conditions have been reported sporadically. The heterogeneity of the works revealed the need for more appropriate oral examination to intercept the oral manifestations of oral mucosa and prevent recurrent candidiasis.

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Pilger, Daniel, Christoph von Sonnleithner, and Eckart Bertelmann. "Assessing full thickness oral mucosal grafting: complications and postoperative outcomes in a broad collective of patients." BMJ Open Ophthalmology 5, no. 1 (February 2020): e000337. http://dx.doi.org/10.1136/bmjophth-2019-000337.

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BackgroundConjunctival defects can be repaired with several mucosal tissues. The simplicity of harvesting oral mucosa and its wide availability makes it the preferred graft tissue for all indications requiring mucosal grafting. Through analysing the postsurgical outcomes and rate of revisions, this study explores the suitability of oral mucosa grafts, depending on the initial diagnosis.MethodsWe reviewed all the files of patients with a history of oral mucosal graft surgery, performed at our clinic between 2012 and 2018, focusing on complications and revision rates.ResultsIn total, we analysed 173 oral mucosa grafts in 131 patients. The most common initial diagnosis was tumour resection, followed by surgical complications, postenucleation socket syndrome, trauma and ocular surface disorders. Complication and revision rates depended highly on the initial diagnosis. Revision rates were highest if the initial diagnosis included ocular surface disorders or chemical trauma.ConclusionsOral mucosa grafting (OMG) is the most effective treatment for a wide range of ocular conditions involving conjunctival defects. Conjunctival defects that result from trauma or cicatricial surface diseases seem less suitable for OMG and may benefit from alternative graft tissue or treatment options.

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Chen, Junning, Rohana Ahmad, Wei Li, Michael Swain, and Qing Li. "Biomechanics of oral mucosa." Journal of The Royal Society Interface 12, no. 109 (August 2015): 20150325. http://dx.doi.org/10.1098/rsif.2015.0325.

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The prevalence of prosthodontic treatment has been well recognized, and the need is continuously increasing with the ageing population. While the oral mucosa plays a critical role in the treatment outcome, the associated biomechanics is not yet fully understood. Using the literature available, this paper provides a critical review on four aspects of mucosal biomechanics, including static, dynamic, volumetric and interactive responses, which are interpreted by its elasticity, viscosity/permeability, apparent Poisson's ratio and friction coefficient, respectively. Both empirical studies and numerical models are analysed and compared to gain anatomical and physiological insights. Furthermore, the clinical applications of such biomechanical knowledge on the mucosa are explored to address some critical concerns, including stimuli for tissue remodelling (interstitial hydrostatic pressure), pressure–pain thresholds, tissue displaceability and residual bone resorption. Through this review, the state of the art in mucosal biomechanics and their clinical implications are discussed for future research interests, including clinical applications, computational modelling, design optimization and prosthetic fabrication.

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Andrews, Brian T., and Douglas K. Trask. "Oral Melanoacanthoma: A Case Report, a Review of the Literature, and a New Treatment Option." Annals of Otology, Rhinology & Laryngology 114, no. 9 (September 2005): 677–80. http://dx.doi.org/10.1177/000348940511400904.

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Objectives: Oral melanoacanthoma is a rare condition that presents as a pigmented, painful lesion, most commonly on the buccal mucosa. Argon plasma coagulation is a new treatment option for benign oral lesions and is hypothesized to be efficacious for this rare mucosal disorder. Methods: Treatment of a case and a review of the English-language literature were performed. Results: One patient received a diagnosis of oral melanoacanthoma, and argon plasma coagulation treatment resulted in ablation of the lesion with excellent mucosal healing. A review of the literature demonstrated that this lesion is most commonly associated with black (90.9%), adult female (69.7%) patients and is most commonly located on the buccal mucosa (64.7%). Conclusions: Oral melanoacanthoma is a rare, benign mucosal lesion that may require surgical intervention for symptomatic relief. Argon plasma coagulation is a relatively safe and effective means of treating this lesion. Argon plasma coagulation treatment may be expanded to include other benign, superficial lesions of the oral mucosa.

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Kansky, Andrej Aleksander, Vojko Didanovic, Tadej Dovsak, Bozana Loncar Brzak, Ivica Pelivan, and Diana Terlevic. "Epidemiology of oral mucosal lesions in Slovenia." Radiology and Oncology 52, no. 3 (September 11, 2018): 263–66. http://dx.doi.org/10.2478/raon-2018-0031.

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Abstract Background Among the diseases of oral mucosa, malignant tumors are the most dangerous, but not the most common lesions that might appear in the oral cavity. Since most of the studies are focused on the detection of cancer in the oral cavity, we were interested in detecting the frequency of benign changes of the oral mucosa in Slovene population. Oral mucosal lesions are important pointer of oral health and quality of life, especially in elderly. The prevalence of oral mucosal lesions, together with information on the risk habits associated with oral health, such as tobacco and alcohol use, can help in planning future oral health studies and screening programs. Patients and methods Survey upon oral mucosal lesions was conducted during the national project for oral cancer screening in spring 2017 in the Slovenia in which more than 50% of dentists participated and 2395 patients (904 men and 1491 women) were included. Results Clinical examination, which was conducted according to the WHO standards revealed that 645 patients (27%) had oral mucosal lesions. The ten most common oral lesions detected were fibroma, gingivitis, Fordyce spots, white coated tongue, cheek biting, linea alba, denture stomatitis, geographic tongue, recurrent aphthous ulcerations and lichen planus. Conclusions Overall, these epidemiological data suggest need for specific health policies for prevention, diagnosis and treatment of oral mucosal lesions.

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Sobkowiak, Michal, Haleh Davanian, Annelie Tjernlund, Anna Gibbs, Sushrusha Nayak, Edwin Leeansyah, Joana Dias, et al. "MAIT cells in the human oral mucosa are activated and perforinlow." Journal of Immunology 198, no. 1_Supplement (May 1, 2017): 149.8. http://dx.doi.org/10.4049/jimmunol.198.supp.149.8.

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Abstract Mucosa-associated invariant T (MAIT) cells are a class of non-classical T lymphocytes defined by their invariant Vα7.2-containing MR1-restricted T cell receptor, as well as high expression of CD161. At present, the characteristics of MAIT cells in the oral mucosa are poorly defined. In this study, we have analyzed buccal biopsies and matched blood samples from a cohort of healthy volunteers. MAIT cells were present in the buccal mucosa, with a tendency to cluster around the basal layer, a region also found to contain a higher frequency of MR1-expressing antigen-presenting cells. The frequency of MAIT cells was similar in the buccal mucosa compared to matched peripheral blood, in contrast to other major T cell subsets. However, the buccal mucosal MAIT cells displayed a tissue resident activated profile, with high CD69, HLA-DR and PD-1 expression, as well as a skewed subset distribution with higher representation of CD4/CD8 double-negative cells and of CD8αα+ cells within the CD8+ subset. The Jα chain usage in the MAIT cell TCR was more variable in oral mucosal MAIT cells than in peripheral blood MAIT cells. Functionally, the oral mucosal MAIT cells had lower perforin levels, indicative of a lower cytolytic potential. Interestingly, aspects of the oral MAIT cell population were associated with life-style factors such as consumption of bacterially fermented milk products and alcohol intake. Together, these data show that MAIT cells form a part of the oral mucosal T cell compartment, where they exhibit a tissue-resident activated profile. Thus, MAIT cells are positioned in the oral cavity and equipped to handle resident microbiota as well as invading pathogens.

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Rekik, Mariem, Khadija Sellami, Massara Baklouti, Emna Bahloul, and Hamida Turki. "Oral involvement in lupus erythematosus: A report of three cases." Our Dermatology Online 13, no. 4 (October 1, 2022): 467–68. http://dx.doi.org/10.7241/ourd.20224.31.

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Sir, Lupus erythematosus (LE) is an autoimmune disease that may rarely affect the oral mucosa. This mucosal damage may be mistaken for lichen planus. Herein, we report three cases of oral lupus. Observation 1: A 41-year-old female, with a seven-year history of systemic LE (SLE) treated with hydroxychloroquine, presented for recent food discomfort. An examination of the oral mucosa found an erythematous plaque on the palate (Fig. 1) and whitish macules on the cheek mucosa. A palatal biopsy was in favor of lupus.

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Barrett, A. W., A. T. Cruchley, and D. M. Williams. "Oral Mucosal Langerhans' Cells." Critical Reviews in Oral Biology & Medicine 7, no. 1 (January 1996): 36–58. http://dx.doi.org/10.1177/10454411960070010301.

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Langerhans' cells (LC) are dendritic, antigen-presenting cells present within the epithelium of skin and mucosa, including that of the oral cavity. This article reviews the literature on the phenotypic and functional features of oral mucosal Langerhans' cells, and speculates on other aspects by extrapolating from data on their epidermal counterparts.

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Moharamzadeh, K., I. M. Brook, R. Van Noort, A. M. Scutt, and M. H. Thornhill. "Tissue-engineered Oral Mucosa: a Review of the Scientific Literature." Journal of Dental Research 86, no. 2 (February 2007): 115–24. http://dx.doi.org/10.1177/154405910708600203.

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Tissue-engineered oral mucosal equivalents have been developed for clinical applications and also for in vitro studies of biocompatibility, mucosal irritation, disease, and other basic oral biology phenomena. This paper reviews different tissue-engineering strategies used for the production of human oral mucosal equivalents, their relative advantages and drawbacks, and their applications. Techniques used for skin tissue engineering that may possibly be used for in vitro reconstruction of human oral mucosa are also discussed.

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Cienfuegos, Ricardo, Eduardo Sierra, Benjamin Ortiz, and Gerardo Fernández. "Treatment of Palatal Fractures by Osteosynthesis with 2.0-mm Locking Plates as External Fixator." Craniomaxillofacial Trauma & Reconstruction 3, no. 4 (December 2010): 223–30. http://dx.doi.org/10.1055/s-0030-1268519.

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Treatment options for palatal fractures range from orthodontic braces, acrylic bars, and arch bars for maxillomandibular fixation to internal fixation, with plates and screws placed under the palate mucosa and periosteum, together with pyriform aperture or alveolar plating plus buttress reconstruction. Forty-five patients, ages 4 to 56, were treated using medium- or high-profile locking plates placed over the palatal mucosa as an external fixator for palatal fractures, together with treatment for other associated facial fractures. In open fractures, plates were placed after approximating the edges of the mucosal wounds. Plates and screws for palate fixation were removed at 12 weeks, when computed tomography scans provided evidence of fracture healing. All palatal fractures healed by 12 weeks, with no cases of mucosal necrosis, bone exposure, fistulae, or infections. This approach achieves adequate stability, reduces the risk of bone and mucosal necrosis, and promotes healing of mucosal wounds in case of open fractures.

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Moharamzadeh, K., H. Colley, C. Murdoch, V. Hearnden, W. L. Chai, I. M. Brook, M. H. Thornhill, and S. MacNeil. "Tissue-engineered Oral Mucosa." Journal of Dental Research 91, no. 7 (January 19, 2012): 642–50. http://dx.doi.org/10.1177/0022034511435702.

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Advances in tissue engineering have permitted the three-dimensional (3D) reconstruction of human oral mucosa for various in vivo and in vitro applications. Tissue-engineered oral mucosa have been further optimized in recent years for clinical applications as a suitable graft material for intra-oral and extra-oral repair and treatment of soft-tissue defects. Novel 3D in vitro models of oral diseases such as cancer, Candida, and bacterial invasion have been developed as alternatives to animal models for investigation of disease phenomena, their progression, and treatment, including evaluation of drug delivery systems. The introduction of 3D oral mucosal reconstructs has had a significant impact on the approaches to biocompatibility evaluation of dental materials and oral healthcare products as well as the study of implant-soft tissue interfaces. This review article discusses the recent advances in tissue engineering and applications of tissue-engineered human oral mucosa.

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Nahas, André Alan, Paula Dechichi, Denildo de Magalhães, and Andreia Espíndola Vieira. "Histologic Analysis of the Oral Mucosa Lining Osseointegrated Implant Cover Screws: A Study in Humans." Journal of Oral Implantology 36, no. 1 (January 1, 2010): 3–10. http://dx.doi.org/10.1563/aaid-joi-d-09-00047.

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Abstract Osseointegrated dental implants are inserted into the alveolar ridge, and for them to function as tooth replacements, the surrounding tissues need to adapt to them. Just as with teeth, dental implants traverse the oral mucosa and have access to the contaminated environment of the oral cavity. Therefore, periodontal and peri-implant tissues are important for establishing a protective barrier. The aim of the present study was to perform a histologic analysis of the mucosa surrounding osseointegrated implant cover screws. For this study, 17 mucosal specimens were obtained from 12 patients during the second surgical session for implant exposure to the oral environment. After histologic preparation, specimens were sectioned perpendicularly to the mucosal surface to a thickness of about 3 µm, stained with 1% toluidine blue, and examined under light microscopy. All specimens showed a keratinized, stratified, squamous epithelium with well-defined strata. In the lamina propria, unorganized dense connective tissue was noted in the reticular layer, and in 4 samples, a chronic inflammatory infiltrate was seen in this region. The papillary layer presented tall connective papillae consisting of loose connective tissue. The results of this study confirm the hypothesis that the mucosa that conceals osseointegrated implant cover screws has the same morphologic characteristics as the alveolar masticatory mucosa. Furthermore, clinical conditions of normality in peri-implant tissues may not coincide with situations of histologic normality.

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Morozova, Viktoriya V., Svetlana V. Tarasenko, Michail A. Stepanov, Sergey A. Kalinin, and Anna G. Maltseva. "Analyzing the efficacy of various treatment options for patients with oral mucosal hyperkeratosis." Russian Journal of Dentistry 25, no. 4 (June 26, 2022): 351–57. http://dx.doi.org/10.17816/1728-2802-2021-25-4-351-357.

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Diseases of the oral mucosa (COR), characterized by a violation of its cornea, constitute a vast group among the variety of diseases of COR, of particular interest is a separate group called hyperkeratosis of the oral mucosa. Current treatment protocols include a variety of therapeutic and surgical methodologies and principles, with surgical excision of the lesion being the primary treatment measure. However, surgical treatments are often associated with increased risks of pain, swelling, bleeding and, recurrence of malignancy. The aim of this review was to identify the optimal treatment option for oral mucosal leukoplakia. The current review included all studies focusing on the treatment of oral mucosal leukoplakia and published between 2016 and 2021. The findings of this study showed that laser surgical treatment of oral mucosal verrucous leukoplakia resulted in statistically significant advantages in the intra- and postoperative periods.

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MANZAK SAKA, Işılay, Demet SAĞLAM AYKUT, and Filiz CİVİL ARSLAN. "Oral dysesthesia with a psychiatric perspective." Mucosa 3, no. 3 (September 30, 2020): 60–64. http://dx.doi.org/10.33204/mucosa.755275.

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Chaiyarit, Ponlatham, Poramaporn Klanrit, Pensri Phothipakdee, Ajiravudh Subarnbhesaj, Kobkan Thongprasom, and Andrew S. Giraud. "Brief communication (Original). Trefoil factor expression by immunohistochemistry in patients with oral lichen planus." Asian Biomedicine 8, no. 6 (December 1, 2014): 743–49. http://dx.doi.org/10.5372/1905-7415.0806.352.

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Abstract Background: Oral lichen planus (OLP) is a chronic immune-mediated inflammatory disease that usually causes oral mucosal damage. OLP has been considered to be a potentially malignant disorder associated with an increased risk for oral cancer. Trefoil factors (TFFs) are mainly synthesized by mucin-producing epithelial cells. Expression of TFFs in oral epithelia is thought to be an essential factor in protection against oral mucosal damage. However, very little is known about the connection between tissue damage of oral mucosa in OLP patients and expression of TFFs. Objectives: To determine levels of TFF expression in oral mucosa from patients with OLP. Methods: Tissue samples were collected from 35 patients with normal oral mucosa (controls) and 35 patients with OLP. An immunohistochemical method was used to determine the expression of the 3 TFFs (TFF1, 2, and 3) in mucosal tissues of the oral cavity. Results:TFF2 and TFF3 expression in oral epithelia were significantly decreased in OLP patients (Mann- Whitney U test; P = 0.006, and P = 0.002, respectively). There were no significant differences in TFF1 expression between OLP patients and control subjects. Conclusion: The present study demonstrated reduced expression of TFF2 and TFF3 in oral epithelia of OLP patients. These outcomes support our previous observations that chronic inflammation may play a major role in downregulation of TFF expression, which may be associated with oral mucosal damage in OLP patients.

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Alonso Pérez, Lucía, and Carmen García Muñoz. "Tratamientos tópicos de los trastornos de la mucosa oral y la mucosa genital. Formulación magistral." Más dermatología, no. 27 (January 1, 2017): 17–20. http://dx.doi.org/10.5538/1887-5181.2017.27.17.

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Kim, Ji-Sun, Byung Guk Kim, and Se Hwan Hwang. "Efficacy of Artificial Intelligence-Assisted Discrimination of Oral Cancerous Lesions from Normal Mucosa Based on the Oral Mucosal Image: A Systematic Review and Meta-Analysis." Cancers 14, no. 14 (July 19, 2022): 3499. http://dx.doi.org/10.3390/cancers14143499.

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The accuracy of artificial intelligence (AI)-assisted discrimination of oral cancerous lesions from normal mucosa based on mucosal images was evaluated. Two authors independently reviewed the database until June 2022. Oral mucosal disorder, as recorded by photographic images, autofluorescence, and optical coherence tomography (OCT), was compared with the reference results by histology findings. True-positive, true-negative, false-positive, and false-negative data were extracted. Seven studies were included for discriminating oral cancerous lesions from normal mucosa. The diagnostic odds ratio (DOR) of AI-assisted screening was 121.66 (95% confidence interval [CI], 29.60; 500.05). Twelve studies were included for discriminating all oral precancerous lesions from normal mucosa. The DOR of screening was 63.02 (95% CI, 40.32; 98.49). Subgroup analysis showed that OCT was more diagnostically accurate (324.33 vs. 66.81 and 27.63) and more negatively predictive (0.94 vs. 0.93 and 0.84) than photographic images and autofluorescence on the screening for all oral precancerous lesions from normal mucosa. Automated detection of oral cancerous lesions by AI would be a rapid, non-invasive diagnostic tool that could provide immediate results on the diagnostic work-up of oral cancer. This method has the potential to be used as a clinical tool for the early diagnosis of pathological lesions.

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Squier, C. A. "The Permeability of Oral Mucosa." Critical Reviews in Oral Biology & Medicine 2, no. 1 (January 1991): 13–32. http://dx.doi.org/10.1177/10454411910020010301.

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In discussing permeability, we are describing one of the fundamental barrier functions of oral mucosa. Despite assumptions to the contrary, the oral mucosa is not a uniformly, highly permeable tissue like gut, but shows regional variation. The keratinized areas, such as gingiva and hard palate, are least permeable and nonkeratinized lining areas are most permeable. This variation appears to reflect differences in the types of lipid making up the intercellular permeability barrier in the superficial layers of the epithelium. Differences in permeability may be related to regional differences in the prevalence of certain mucosal diseases and can be utilized to advantage for local and systemic drug delivery.

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Khan, Faisal, Sarah Sy, Polly Louie, Robyn Lee, Douglas A. Stewart, James A. Russell, and Jan Storek. "Genomic Instability Is Frequent in Oral and Rare in Nasal Mucosal Cells of Allogeneic HCT Recipients." Blood 112, no. 11 (November 16, 2008): 2140. http://dx.doi.org/10.1182/blood.v112.11.2140.2140.

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Abstract Genomic Instability (GI), appraised by microsatellite length alteration, is a precancerous or cancerous condition. We hypothesized that genomic instability is frequent in oral but not nasal mucosal cells of HCT recipients as oral but not nasal carcinoma is frequent in long-term HCT survivors.We examined epithelial cells from buccal and nasal mucosa of 35 subjects for the presence of GI at 15 microsatellite loci spanning 14 human autosomes. The study population included long-term allo-HCT survivors (4–22 yrs, n=18) and short-term allo-HCT survivors (2–3 months, n=5), and long-term auto-HCT survivors (4–12 yrs, n=5). Controls also included 5 patients treated with intensive chemotherapy and 2 healthy volunteers. DNA extracted from peripheral blood leukocytes and cells of nasal and buccal mucosa was PCR amplified for a panel of 15 Short tandem repeat (STR) markers (ABI-Identifiler TM). The amplicons were subjected to capillary electrophoresis and fragment size analysis was performed to identify novel allele peaks (one that was absent in donor and recipient blood pre-transplant but present in recipient mucosa post-transplant) indicative of microsatellite instability (MSI). MSI was observed in buccal mucosal cells of 56% long-term survivors of allo-HCT; the number of STR loci showing novel allele peaks ranged from 1–6 (median=3). None of the short-term survivors of allo-HCT, long-term survivors of auto-HCT, or control individuals showed MSI in the buccal mucosal cells. Only one allogeneic HCT survivor showed MSI (at one STR locus) in nasal mucosal cells. No genomic alterations were observed in blood leukocytes of any of the above patients or controls. In conclusion, genomic instability is frequently observed in long-term allo-HCT suvivors in oral mucosal cells but rarely in nasal mucosal cells. The facts that oral but not nasal mucosa is frequently involved in chronic GVHD and that MSI was not detected in recipients of auto-HCT suggest that graft-vs-host reaction induces genomic instability.

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SUGIYAMA, Y., S. ISHIBASHI, S. SEKIYAMA, K. SERA, and S. FUTATSUGAWA. "TRACE ELEMENT ANALYSIS OF THE ORAL MUCOSA OF 22 PATIENTS WITH ORAL LICHEN PLANUS BY THE PIXE METHOD." International Journal of PIXE 12, no. 03n04 (January 2002): 159–66. http://dx.doi.org/10.1142/s0129083502000263.

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We made a comparative study of the trace elements in the oral mucosa of 22 patients with oral lichen planus (OLP) and of 100 healthy persons by the PIXE method. Samples were excised from the oral mucosa of the OLP patients (OLP group) and from the buccal mucosa of healthy persons (control group). The results were as follows: Seventeen trace elements and 11 contaminating elements were detected in those oral mucosae. Al , Ti and Pb , which are contaminating elements, were detected in more than 65% of samples from both groups. The mean values of Se and Rb were significantly lower in the OLP group than in the control group. The mean values of the other elements did not differ significantly between the groups. As for the females over 30 years old, the OLP group showed significantly higher values of Zn and Sr than the control group. Their mean values of the other essential and contaminating elements did not differ significantly between the groups, although there was a trend toward higher values in the OLP group. We found by the PIXE method that Zn , Fe and Pd , which are d-transitional elements considered to cause allergic reaction, showed higher values in the oral mucosae of the OLP patients than in those of the healthy persons.

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Journal articles on the topic 'Mucosa Orale'

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