Academic literature on the topic 'Mucosa nasale'
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Journal articles on the topic "Mucosa nasale"
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Gambardella, R. "A Comparison of the Efficacy of Azelastine Nasal Spray and Loratidine Tablets in the Treatment of Seasonal Allergic Rhinitis." Journal of International Medical Research 21, no. 5 (September 1993): 268–75. http://dx.doi.org/10.1177/030006059302100505.
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A total of 30 patients suffering from seasonal allergic rhinitis were treated in a 6-week randomized, double-blind, double-dummy parallel-group study, comparing azelastine nasal spray (0.14 mg/nostril administered twice daily) and loratidine tablets (10 mg once daily). Symptoms evaluated were sneezing, nose and/or eye itching, lacrimation, rhinorrhoea, photophobia, nasal occlusion, throat irritation, smell loss, nasal mucosa swelling, conjunctivitis, and pharyngeal mucosa reddening. Each symptom was assessed according to severity and given a score on a fourpoint rating scale. Compared with baseline, total symptom scores for both the azelastine and loratidine treatment groups were reduced at each of the assessments during treatment. No significant differences were observed between the two treatment groups. The investigator concluded that azelastine, formulated as a nasal spray, is as effective as loratidine tablets in the relief of the symptoms of seasonal rhinitis and that it has a rapid onset of action. Un gruppo di 30 pazienti affetti da rinite allergica stagionale è stato trattato, in uno studio radomizzato, tra gruppi paralleli, doppio cieco, double dummy della durata di 6 settimane con azelastina spray nasale (0.14 mg/narice 2 volte al giorno) e loratina compresse (10 mg/die). I sintomi controllati sono stati i seguenti: starnuti, prurito nasale e/o oculare, lacrimazione, rinorrea, fotofobia, occlusione nasale, irritazione faringea, perdita dell'olfatto, edema della mucosa nasale, congiuntivite ed arrossamento della mucosa faringea. I sintomi sono stati valutati in base alia loro gravità assegnando un punteggio variabile da 1 a 4. In entrambi i gruppi di trattamento il punteggio totale della sintomatologia è risultato inferiore a quello basale ad ogni controllo nel corso dei trattamenti. Non sono state rilevate differenze significative tra i due trattamenti che si sono dimostrati entrambi efficaci. I ricercatori hanno concluso che azelastina spray nasale ha la stessa efficacia di loratidina compresse nell'alleviare i sintomi della rinite allergica stagionale e possiede una notevole rapidità di azione ed una notevole maneggevolezza clinica.
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De Bont, J., D. Van Aken, J. Vercruysse, J. Fransen, V. R. Southgate, and D. Rollinson. "The prevalence and pathology of Schistosoma nasale Rao, 1933 in cattle in Sri Lanka." Parasitology 98, no. 2 (April 1989): 197–202. http://dx.doi.org/10.1017/s0031182000062107.
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SUMMARYDuring 1987 a total of 1393 cattle was examined for Schistosoma nasale infection at the Kandy slaughterhouse, Sri Lanka. The overall prevalence was 12·6% (monthly range 3–17%). Based on the appearance of macroscopic lesions, 6 types (0–5) were recognized; type 5 being the most severe, with cauliflower-like growths obstructing the nasal cavity. Older bovines with 8 permanent incisors were more heavily infected (29·%) than younger ones with no permanent incisors (6·0%). The severity of the lesions increased also with the age of the animals. Observations on the localization of the lesions showed that the first sessile nodular areas appear on the medial septum, on the dorsal edge of the ventral nasal concha and on the lateral wall of the middle meatus of the nasal cavity. Later, they gradually spread over the whole mucosal surface of the anterior part of the cavity but were rarely found further than 10 cm posterior to the nasal opening. The histopathology showed that granuloma formation due to the presence of eggs was the most common feature of the respiratory mucosa.
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Hoy, Nathan, Joyce Wong, Muhammad Mahmood, and Alain Brassard. "Basaloid Squamous Cell Carcinoma of the Nasal Septum Presenting as a Primary Cutaneous Lesion." Journal of Cutaneous Medicine and Surgery 16, no. 5 (September 2012): 375–77. http://dx.doi.org/10.1177/120347541201600520.
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Background: Basaloid squamous cell carcinoma is a rare aggressive variant of squamous cell carcinoma, with a predilection for the head and neck region. There are only two case reports in the literature documenting a nasal cavity squamous cell carcinoma presenting as a primary cutaneous lesion. Objective: We report a rare case of nasal cavity basaloid squamous cell carcinoma presenting initially as a nasal bridge mass. Two initial biopsies revealed features consistent with basal cell carcinoma and basosquamous cell carcinoma, respectively. Result: Final surgical pathology showed extensive invasive squamous cell carcinoma with basaloid differentiation arising from the nasal septal mucosa with extension to the overlying skin. The clinicopathologic features were interpreted as basaloid squamous cell carcinoma. Conclusion: We discuss the difficulties in pathologic diagnosis of this condition given its varied phenotypical expression. As well, this case emphasizes the necessity for diagnostic vigilance when assessing a primary cutaneous lesion as it may be a rare presentation of an underlying malignancy extending to the skin. Contexte: Le carcinome squameux basaloïde est une variante rare et très maligne du carcinome squameux, qui touche le plus souvent la tête et le cou. La documentation médicale ne compte que deux exposés de cas sur le carcinome squameux de la cavité nasale se présentant sous forme de lésion cutanée primitive. Objectif: Nous faisons état ici d'un rare cas de carcinome squameux basaloïde de la cavité nasale, se présentant au départ comme une masse dans la voûte des fosses nasales. Deux biopsies ont été pratiquées au départ, et les résultats se sont montrés compatibles avec les caractéristiques du carcinome basocellulaire et du carcinome basospinocellulaire, respectivement. Résultat: L'examen histopathologique définitif de la pièce opératoire a révélé la présence d'un carcinome squameux invasif, étendu, accompagnée d'une différenciation basaloïde prenant naissance dans la muqueuse de la cloison nasale et se prolongeant jusqu'à la peau sus-jacente. Les manifestations clinicopathologiques laissaient croire à un carcinome squameux basaloïde. Conclusion: Il sera question ici des difficultés que pose le diagnostic histopathologique de cette affection compte tenu de son expression phénotypique variée. De plus, le cas met en évidence la nécessité de faire preuve de vigilance dans l'établissement du diagnostic lorsqu'on évalue des lésions cutanées primitives étant donné que celles-ci peuvent être une manifestation rare d'une tumeur maligne sous-jacente, qui s'étend jusqu'à la peau.
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Chiba, Yoshihiko, Michiko Oshita, Kensuke Matsuo, Hiroyasu Sakai, and Miwa Misawa. "Comparison of Norepinephrine Responsiveness of Mucosal Veins in Vivo with that of Isolated Mucosal Tissue in Vitro in Guinea Pig Nasal Mucosa." American Journal of Rhinology 20, no. 3 (May 2006): 349–52. http://dx.doi.org/10.2500/ajr.2006.20.2853.
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Background The vascular responsiveness of nasal mucosa has been determined frequently by using isolated mucosal tissues although it is not clear whether the response of the whole tissue truly reflects the response of the vasculature (especially veins) in mucosa. In this study, the in vivo responsiveness of mucosal veins was compared with in vitro responsiveness of isolated mucosal tissue in guinea pig nasal septa. Methods The in vivo venous responsiveness to norepinephrine (NE) of guinea pig nasal septal mucosa was measured by changes in the diameters of mucosal veins, stereomicroscopically. The in vitro responsiveness to NE of isolated nasal septal mucosae from guinea pigs also was determined by standard organ-bath technique. Results Application of NE induced concentration-dependent contractile responses both in vivo and in vitro with the pD2 (negative logarithm for 50% effective concentration [M] of NE) values of 5.23 ± 0.29 and 5.00 ± 0.17, respectively. Conclusion The equal potencies obtained by the in vivo and in vitro experiments suggest that an increase in tension of isolated nasal mucosal tissue might be caused by the contraction of mucosal veins. Both the in vivo and the in vitro methods used in this study might be useful for determining vasoreactivity of nasal mucosa in experimental animals.
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Elsheikh, Ezzeddin, Mohammad El-Anwar, and Hesham Abdel-aziz. "Impact of Successful Choanal Atresia Repair on the Nasal Mucosa: A Preliminary Study." International Archives of Otorhinolaryngology 21, no. 03 (March 28, 2017): 276–80. http://dx.doi.org/10.1055/s-0037-1601404.
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Introduction The main histological features of the nasal mucosa in choanal atresia are distorted cilia, marked increase of mucous submucosal glands associated with marked reduction of goblet cell density, and lymphocytic cellular infiltration. Objective To study the nasal mucosal changes in cases of choanal atresia after successful repair compared with pre-repair mucosal histological features. Methods Tissue samples were taken from the inferior turbinate of 3 patients (1 bilateral and 2 unilateral) who were successfully operated. Then, the biopsies were subjected to histopathological, histochemical and immunohistochemical studies. After that, the results were compared with pre-repair findings in the choanal atresia side and in the normal side. Results Four biopsies (4 repaired choanal atresia sides) of the mucosa of the inferior turbinate revealed that 1 patient (who had a bilateral choanal atresia repaired), after achieving a patent choana for 8 months, had not completely recovered a normal nasal mucosa. The other 2 patients, after 18 and 23 months of achieving a patent choana, showed normal nasal cavities. Conclusion The main histological features of the nasal mucosa in choanal atresia could be reversed by surgery, making the patients regain their choanal patency, with their mucosae changing back to normal gradually with time.
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Chiba, Yoshihiko, Kensuke Matsuo, Hiroyasu Sakai, Kazuho Abe, and Miwa Misawa. "Increased Expression of Inducible Nitric Oxide Synthase in Nasal Mucosae of Guinea Pigs with Induced Allergic Rhinitis." American Journal of Rhinology 20, no. 3 (May 2006): 336–41. http://dx.doi.org/10.2500/ajr.2006.20.2852.
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Background Nitric oxide (NO) is produced by the action of NO synthase (NOS) isoforms and is considered an important mediator of inflammatory response including airways. In this study, the changes in the expression levels of NOS isoforms in nasal mucosae were determined in a guinea pig model of allergic rhinitis. Methods An allergic rhinitis model was prepared in guinea pigs by repeated challenge with aerosolized dinitrophenylated ovalbumin antigen. Twenty-four hours after the last antigen challenge, the expression levels of NOS isoforms in nasal mucosae were determined by immunoblottings. Changes in the isometrical tension of isolated mucosal tissues of nasal septa induced by histamine were measured also. Results Although the expression levels of endothelial NOS (eNOS) and neuronal NOS (nNOS) in nasal mucosae were not affected by the repeated antigen exposure, the inducible NOS (iNOS) level was markedly and significantly increased in the challenged animals. In isolated nasal mucosal tissues, histamine induced a concentration-dependent relaxation, which was sensitive to an H1-receptor antagonist, mepyramine, and an NOS inhibitor, l-NMMA. No significant change in the histamine responsiveness was observed between the sensitized control and repeatedly antigen-challenged groups. Conclusion The expression of three isoforms of NOS, including eNOS, nNOS, and iNOS, was presented in guinea pig nasal mucosa. A marked increase in iNOS expression in the repeatedly antigen-challenged animals suggests an important role of iNOS in the pathogenesis of allergic rhinitis. However, the pathophysiological role(s) of NO generated by iNOS in nasal allergy is still unclear.
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Saito, Hitoshi, and Toshihito Tsubokawa. "Ciliary Activity of Nasal Polyp and Mucosa in Chronic Sinusitis." American Journal of Rhinology 5, no. 6 (November 1991): 215–18. http://dx.doi.org/10.2500/105065891781874857.
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Ciliary activity of mucosal cells of nasal polyps and the maxillary sinus mucosa in chronic sinusitis cultured in vitro were measured by a photoelectric method. The findings were compared with those of normal maxillary sinus and inferior turbinate mucosae. The ciliary beating of edematous type of nasal polyp, 955 ± 130 beats/min (mean ± SD), did not differ significantly from the normal control, whereas both the duration and rate of ciliary beating were significantly decreased with cystic and fibrous type polyps. Ciliary activity in chronic sinusitis was significantly inhibited in the order of fibrous, purulent, and edematous types. The total area of ciliated mucosa also was decreased and varied with the type of chronic sinusitis, showing the most marked decrease with fibrous type. The ciliary activity in chronic sinusitis showed impairment with respect to both decreased ciliary rate of beating and reduced ciliated area.
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Feng, Zhaoxuan, Minglu Li, Xing Jin, Yudong Zheng, Junxiu Liu, Liang Zhao, Yansen Wang, Hao Li, and Danlin Zuo. "Design and characterization of plasticized bacterial cellulose/waterborne polyurethane composite with antibacterial function for nasal stenting." Regenerative Biomaterials 7, no. 6 (October 15, 2020): 597–608. http://dx.doi.org/10.1093/rb/rbaa029.
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Abstract A nasal stent capable of preventing adhesions and inflammation is of great value in treating nasal diseases. In order to solve the problems of tissue adhesion and inflammation response, we prepared plasticized bacterial cellulose (BCG) and waterborne polyurethane (WPU) composite with antibacterial function used as a novel nasal stent. The gelation behavior of BCG could contribute to protecting the paranasal sinus mucosa; meanwhile, the WPU with improved mechanical property was aimed at supporting the narrow nasal cavity. The thickness, size and the supporting force of the nasal stent could be adjusted according to the specific conditions of the nasal. Thermogravimetric analysis, contact angle and water absorption test were applied to investigate the thermal, hydrophilic and water absorption properties of the composite materials. The composite materials loaded with poly(hexamethylene biguanide) hydrochloride maintained well antibacterial activity over 12 days. Animal experiments further revealed that the mucosal epithelium mucosae damage of BCG−WPU composite was minor compared with that of WPU. This new type of drug-loaded nasal stent can effectively address the postoperative adhesions and infections while ensuring the health of nasal mucosal, and thus has an immense clinical application prospects in treating nasal diseases.
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Martín-Villares, Cristina, Laura Díez-González, Gerardo Martín-Sigüenza, Ana Rodríguez, Jesús Eduardo Ramírez, and Ignacio Álvarez-Álvarez. "Pólipos nasales, cirugía de revisión e inflamación eosinofílica." Revista ORL 13, S2 (February 9, 2023): 155–56. http://dx.doi.org/10.14201/orl.29027.
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Introducción y objetivo: El tratamiento de la poliposis nasal son los corticoides, y si fallan, la cirugía. Sin embargo, muchos pacientes necesitan cirugías sucesivas, por lo que necesitan mejores tratamientos La investigación básica sobre respuesta inmune inflamatoria tipo 2 en mucosa rinosinusal nos ofrece la posibilidad de bloquear la reacción inflamatoria inmunomediada en la mucosa de pacientes con poliposis nasal. Disponemos de anticuerpos monoclonales capaces de bloquear inmunoglobulinas Il-4 e Il-13, Il-5 y eosinófilos e IgE en la mucosa nasal. Dada la asociación entre pólipos nasales e inflamación tipo 2 en el 85% de los pacientes, el conocimiento sobre eosinófilos y terapias biológicas podría cambiar el manejo de las recurrencias de pólipos y podría evitar procedimientos sucesivos o cirugías radicales.Método: Revisamos una cohorte retrospectiva de pacientes sometidos a CENS en nuestro Departamento entre el 1 de enero de 2016 y el 30 de diciembre de 2020, con más de un año de seguimiento. Todos los procedimientos quirúrgicos se realizaron con la técnica descrita por Stammberger: se respetó la mucosa sana y se abrieron todas las cavidades sinusales patológicas. Las muestras de tejido quirúrgico se tiñeron con hematoxilina-eoxilina y se realizó la identificación de eosinófilos. Se investigó la tasa de cirugía de revisión quirúrgica. Finalmente, se comunica los datos de nuestra experiencia preliminar en productos biológicos para pacientes con pólipos nasales. Resultados: La tasa global de cirugía de revisión fue del 18%. Se realizó recuento de eosinófilos en 157 pacientes con pólipos nasales. De ellos, el 71% (n=111) presentó un recuento elevado de eosinófilos en las piezas quirúrgicas. Los pacientes con pólipos nasales y un recuento elevado de eosinófilos tuvieron una Tasa de Revisión Quirúrgica del 34,2% (38/111). Si los eosinófilos no estaban elevados en el tejido polipoideo, la Tasa de Revisión Quirúrgica fue del 16,6% (8/48), con diferencias significativas en la prueba de Chi-cuadrado (p=0,0125). La comparación de pacientes con alto recuento de eosinófilos en la mucosa reveló un OR de 3,2117 (IC95% 1,2440-8,2918). Se administra terapia biológica en 5 pacientes con asma grave mal controlada con corticoides y beta agonistas. A pesar del corto seguimiento, hasta la fecha no hemos reintervenido paciente tras biológicos.Discusión y Conclusiones: Muchos pacientes con pólipos nasales necesitan cirugías sucesivas, por lo que necesitan un mejor tratamiento. Es importante considerar los factores específicos del paciente que afectan las tasas de cirugía de revisión, como el recuento elevado de eosinófilos, para encontrar mejores tratamientos. Las terapias biológicas pueden cambiar el manejo de las recurrencias de pólipos y podrían evitar procedimientos sucesivos o cirugías radicales en estos pacientes de alto riesgo.
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Talmi, Yoav P., Jacob Bar-Ziv, David Cohen, Yehuda Finkelstein, and Jona Kronenberg. "Computed Tomography Study of Sinus Involvement in Ozena." American Journal of Rhinology 9, no. 5 (September 1995): 281–84. http://dx.doi.org/10.2500/105065895781808810.
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Atrophic rhinitis or ozena is a chronic nasal disease characterized by formation of foul smelling nasal crusts with subsequent turbinate mucosal atrophy and resorption of the underlying bone. This symptom complex involves nasal and sinus mucosa with resultant mucosal atrophy, as well as reduced or absent mucocilliary function. The question of the presence of sinusitis in ozena is yet unanswered. Mucosal atrophy may lead to widely patent sinus ostia, but it may well be that the nasal mucosal disease also involves the sinus mucosa with reduced ciliary motility and ensuing sinusitis. We have undertaken a prospective CT study of 11 ozena patients in order to define the occurrence of sinusitis in this entity. These studies, corroborated in part by nasal endoscopies, demonstrate a 70% ethmoid sinus involvement. The sphenoid, frontal, and maxillary sinuses are not usually involved. Other CT criteria of ozena are described.
Dissertations / Theses on the topic "Mucosa nasale"
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Verhoeven, Paul. "Colonisation muqueuse par Staphilococcus aureus et persistance du portage nasal." Thesis, Saint-Etienne, 2015. http://www.theses.fr/2015STET013T.
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La colonisation nasale à Staphylococcus aureus est un important facteur de risque d’infection par cette bactérie chez l’homme. Le rôle de la colonisation extra-nasale dans la physiopathologie des infections liées à la souche de colonisation est incertain. Contrairement aux porteurs intermittents et aux non porteurs, les porteurs persistants ont un risque accru d’infection à S. aureus notamment chez les patients dialysés. Nous avons développé et proposé une nouvelle stratégie applicable aux soins courants pour prédire rapidement le statut de portage nasal persistant de S. aureus dans l’optique de faire bénéficier les porteurs les plus à risque d’infection à S. aureus de mesures de prévention ciblées. Nous avons montré, à travers l’étude des réservoirs pharyngé et digestif, qu’il existe une grande diversité génétique des souches de S. aureus isolées des muqueuses. Enfin, différentes hypothèses ont été investiguées pour déterminer les facteurs microbiologiques associés à la persistance du portage nasal de S. aureus. Ces résultats préliminaires suggèrent que les souches isolées de colonisation nasale persistante et intermittente ont des caractéristiques très similairesStaphylococcus aureus nasal carriage is a major risk factor of infection with this bacterium in humans. The role of S. aureus extra-nasal carriage in endogenous infections remain elusive. By contrast to intermittent carriers and noncarriers, persistent carriers have a higher risk of S. aureus infection, especially in dialysis patients. We have developed and validated an algorithm to predict the nasal carriage state in clinical practice for proposing decolonization to carriers having the highest risk of S. aureus infection. We found a high diversity between S. aureus strains colonizing the nose, the throat and the rectum, suggesting that extra-nasal carriage could be an additional risk factor of S. aureus infection. Finally, we studied several bacterial determinants of persistent nasal carriage. Our preliminary results suggest that S. aureus isolated in persistent and intermittent carriers harboured similar features
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Amini, Salah Eddine. "Apport de la transgénèse murine dans l’étude des mucines gélifiantes : intérêt dans la compréhension de la physiologie de l’épithélium nasal et la physiopathologie de l’atteinte intestinale consécutive à une chimiothérapie." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S032.
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Le mucus est un gel viscoélastique complexe. Il est essentiel au maintien de l’intégrité des muqueuses et de leurs fonctions. Sa fraction organique est représentée principalement par les mucines gélifiantes (GFM). Seuls les modèles animaux génétiquement modifiés par recombinaison permettent l’étude du rôle des GFM en conditions physiologiques ou pathologiques dans un système parfaitement intégré.Nous avons utilisé ce type de modèles de souris transgéniques pour : 1- préciser l’expression et la localisation respective des deux principales GFM des cavités nasales, Muc5ac et Muc5b, à partir de souris Muc5b-GFP et Muc5b -/- ; 2- étudier les conséquences d’une chimiothérapie d’induction sur la barrière intestinale iléale et évaluer le bénéfice d’un mucus renforcé dans ce contexte grâce à des souris Tg222.Nos résultats montrent : 1-qu’en condition physiologique, Muc5ac qui est préférentiellement fucosylée, est produite dans l’épithélium respiratoire, alors que Muc5b qui est préférentiellement sialylée, est produite par les glandes de Bowman dans l’épithélium olfactif; 2- qu’après une chimiothérapie, un mucus renforcé ne permet pas de réduire les dommages initiaux de l’épithélium iléal qui sont aggravés par la présence du microbiote, mais qu’ensuite c’est l’interaction entre ce microbiote et le mucus qui permet une meilleure régénération de cet épithélium.Ces résultats soulignent le rôle essentiel qu’a le mucus dans l’interaction entre le microbiote et l’épithélium des muqueuses. Ils offrent des perspectives intéressantes de recherche dans la compréhension de l’atteinte de l’olfaction et l’atteinte intestinale chez les patients qui reçoivent une chimiothérapieMucus is a complex viscoelastic gel. It is essential for maintaining the mucosa integrity and their functions. Its organic fraction is mainly represented by gel forming mucins (GFM). Only animal models genetically modified by recombination allow the study of their roles under physiological or pathological conditions in a perfectly an integrated system.We used this type of transgenic mouse model: 1- to specify the expression and localization of the two main nasal cavity GFM, Muc5ac and Muc5b, from Muc5b-GFP and Muc5b -/- mice; 2- to study the consequences of induction chemotherapy on the ileal intestinal epithelium and to evaluate the benefit of a strengthen mucus from Tg222 mice in this context.Our results show: 1- under physiological conditions, Muc5ac which is preferentially fucosylated, is produced in the respiratory epithelium, whereas Muc5b, which is preferentially sialylated, is produced by the Bowman glands in the olfactory epithelium; 2- after chemotherapy, a strengthen mucus does not reduce the initial damage of the ileal epithelium which are aggravated by the presence of the microbiota, but then it is the interaction between this microbiota and mucus that allows better regeneration of this epithelium.These results highlight the essential role mucus plays in the interaction between the microbiota and the mucosal epithelium. They offer interesting perspectives of research in the understanding of the impairment of olfaction and intestinal damage in patients receiving chemotherapy
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Nicola, Marina Lazzari. "Efeitos do tabagismo sobre o transporte mucociliar nasal, propriedades físicas do muco, pH do condensado do ar exalado, celularidade e citocinas de lavado nasal de jovens." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5170/tde-29042014-104441/.
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O tabagismo está fortemente associado ao desenvolvimento da Doença Pulmonar Obstrutiva Crônica, porém poucos estudos que relatam alterações funcionais ou inflamatórias nas vias aéreas superiores em jovens são encontrados na literatura. Nosso objetivo foi investigar as alterações funcionais e inflamatórias nas vias aéreas superiores e inferiores em jovens tabagistas com idade igual ou inferior a 35 anos. Setenta e dois indivíduos participaram do estudo: 32 jovens não tabagistas (JNT) saudáveis (21±4 anos, 29 homens) e 40 jovens tabagistas subdivididos de acordo com a carga tabágica: menor que 2,5 anos-maço (< 2,5) (19±2 anos, 20 homens) e igual ou maior que 2,5 anos-maço (>= 2,5) (24 ± 5 anos, 17 homens e três mulheres). Foram avaliados os dados demográficos, os dados clínicos, os sintomas de desconforto das vias aéreas por meio do questionário SNOT-20, os volumes e capacidades pulmonares por meio do teste de função pulmonar, o transporte mucociliar nasal por meio do teste de tempo de trânsito da sacarina, a propriedade de superfície do muco nasal por meio do ângulo de contato, a inflamação na cavidade nasal por meio da contagem total e diferencial das células e citocinas em lavado nasal e a inflamação de vias aéreas inferiores por meio do pH do condensado do ar exalado. Observamos neste estudo que os jovens tabagistas >= 2,5 foram mais velhos comparados aos JNT e com os tabagistas < 2,5 (p < 0,01). Comparados com os JNT, os tabagistas >= 2,5 apresentaram maior índice de massa corporal (p=0,036), de frequência cardíaca (p=0,001) e de pressão arterial sistólica (p=0,036). Os tabagistas >= 2,5 apresentaram maior queixa sobre tosse (p=0,05) e secreção nasal escorrendo para a garganta (p=0,016) quando comparados com os JNT e tabagistas < 2,5. Não encontramos diferenças significativas na pontuação total do questionário SNOT-20 (p=0,140), nos valores do teste de função pulmonar e nos valores do ângulo de contato (p=0,803) entre os grupos. O tempo de trânsito da sacarina foi significativamente menor nos jovens tabagistas (5,9 ± 3,1 minutos) quando comparados aos JNT (7,7 ± 4,1 minutos, p=0,033). Na análise do lavado nasal encontramos maior número de células totais em tabagistas < 2,5 (48+-14) e tabagistas >= 2,5 (37+-25) comparados aos JNT (24+-12, p < 0,001). Encontramos também maior número de macrófagos (p=0,001), células ciliadas (p=0,008) e células caliciformes (p=0,004) nos tabagistas < 2,5 e tabagistas >= 2,5 quando comparados aos JNT, e maiores concentrações de mieloperoxidase nos tabagistas < 2,5 comparados aos tabagistas >= 2,5 (p=0,005). Os valores do pH do EBC foram menores em tabagistas >= 2,5 (7,65 ± 0,42) comparados com os tabagistas < 2,5 (7,83 ± 0,26) e com os JNT (7,90 ± 0,21, p=0,038). Por meio de análise de regressão linear, verificamos um efeito dose-dependente significativo do tabagismo sobre a redução dos valores do pH do EBC (r=-0,47, p < 0,001). Concluímos que o tabagismo em jovens tabagistas com idade igual ou inferior a 35 anos induz alterações do transporte mucociliar nasal, inflamação nasal e inflamação em vias aéreas inferiores e que essas alterações estão associadas à carga tabágicaCigarette smoking is strongly associated with the development of Chronic Obstructive Pulmonary Disease, but few studies that reported functional or inflammatory changes in upper airway in young are found in the literature. We aimed to evaluate the effects of smoking on nasal mucociliary clearance, the mucus surface property and if there is inflammation in the nasal cavity and lower airways in young smokers aged less than 35 years. Of the 200 individuals contacted by telephone, 72 individuals entered in the study: 32 healthy young nonsmokers (YNS) (21 ± 4 years, 29 male) and 40 young smokers, subdivided according to smoking history: less than 2.5 pack-years (< 2.5) (19 ± 2 years, 20 male) and 2.5 pack-years or more ( >= 2.5) (24 ± 5 years, 17 male and three female). We assessed demographic data, clinical data, SNOT-20 questionnaire for symptoms of airway discomfort, the volumes and lung capacities by the pulmonary function test, the nasal mucociliary clearance using the saccharine transit test, the mucus surface property by the contact angle, the inflammation in the nasal cavity by the total and differential count of cells and cytokines in nasal lavage and inflammation of the lower airways by the exhaled breath condensate pH. In this study, we observed that young smokers >= 2.5 were older compared to YNS and smokers < 2.5 (p < 0.01). Compared with YNS, smokers >= 2.5 had higher body mass index (p=0.036), heart rate (p=0.001) and systolic blood pressure (p=.036). Smokers >= 2.5 complained more about cough (p = 0.05) and post-nasal discharge (p=0.016) when compared to YNS and smokers < 2.5. No significant differences were found in the total score of the SNOT-20 (p=0.140), in the pulmonary function test and mucus contact angle (p=0.803) between groups. The saccharine transit time was significantly lower in young smokers (5.9 ± 3.1 minutes) compared to YNS (7.7 ± 4.1 minutes, p=0.033). The number of total cells in nasal lavage fluid were greater in smokers < 2.5 (48±14) and smokers >= 2.5 (37 ± 25) compared to YNS (24 ± 12, p < 0.001). We also found greater number of macrophages (p=0.001), ciliated cells (p=0.008) and goblet cells (p = 0.004) in smokers < 2.5 and smokers >= 2.5 compared to YNS and a higher concentration of myeloperoxidase in smokers < 2.5 compared to smokers >= 2.5 (p=0.005). The EBC pH were lower in smokers >= 2.5 (7.65 ± 0.42) compared with smokers < 2.5 (7.83 ± 0.26) and with YNS (7.90 ± 0.21, p=0.038). Linear regression analysis confirmed a significant dose-dependent effect of smoking in decreasing EBC pH (r= -0.47, p < 0.001). We conclude that cigarette smoking induces changes in nasal mucociliary clearance, nasal inflammation and inflammation in the lower airways in young smokers aged less than 35 years and these changes are associated with smoking history
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Bezerra, Thiago Freire Pinto. "O papel do biofilme na rinossinusite crônica com polipose nasossinusal." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-01082012-135039/.
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Introdução: A patogenia da rinossinusite crônica com polipose nasossinusal não está completamente estabelecida e existem algumas explicações para essa doença como os superantigenos, o desequilíbrio inflamatório e, mais recentemente, o biofilme. Objetivos: Avaliar a associação entre a presença do biofilme e a presença de rinossinusite crônica com polipose nasossinusal. Avaliar o quadro clínico e radiológico pré-operatória e pós-operatória segundo a presença do biofilme. Métodos: Este é uma estudo realizado em um hospital terciário universitário. A primeira parte foi um estudo caso-controle com um grupo de 33 pacientes consecutivos com rinossinusite crônica com polipose nasossinusal submetidos a cirurgica endoscópica nasossinusal e um grupo controle de 27 pacientes submetidos a septoplastia para tratamento de obstrução nasal. As amostras da mucosa foram coletadas no intra-operatório para avaliação por microscopia eletrônica de varredura para determinar a presença do biofilme. A segunda parte foi um estudo prospectivo em que dados pré-operatórios e pós-operatórios foram registrados, incluindo avaliações padronizadas da qualidade de vida doença-específica relacionadas à obstrução nasal e à rinossinusite, da endoscopia nasal e da tomografia de cavidades paranasais. A análise estatísca foi realizada. Para todos os testes um p=0.05 foi considerado significativo. Resultados: Os biofilmes foram encontrados em 72.7% (24/33) dos pacientes com rinossinusite crônica com polipose nasossinusal e 48.1% (13/27) dos pacientes submetidos a septoplastia (Odd ratio=2.87, IC95% 0.9796-8.419, p=0.051). Este foi o primeiro estudo a analisar o efeito da presença do biofilme nos resultados pós-operatórios com medidas padronizadas de um grupo de pacientes apenas com rinossinusite crônica com polipose nasossinusal. O biofilme estava presente em 72.4% (21/29) dos pacientes que completaram o seguimento. Os pacientes com biofilmes apresentaram uma pior pontuação pré-operatória NOSE e Lund-Kennedy estatísticamente significativos, mas uma mediana semelhante na pontuação total do SNOT-20. Os pacientes com biofilme apresentaram uma melhor resultado na pontuação Lund-Kennedy (p=0.036). Estes pacientes apresentaram piores resultados no SNOT-20 e resultados similares quanto ao NOSE e o Lund-Mackay. Conclusão: Os biofilmes foram demonstrados presentes nos pacientes submetidos a cirurgia endoscópica funcional para rinossinusite crônica com polipose nasossinusal mas também nos controles. Embora a prevalência não tenha sido diferente significativamente, o intervalo de confiança extremamente amplo de 95%, que apenas cruza a unidade, sugere que uma diferença significativa pode ter sido perdida por causa do baixo poder estatístico e estudos futuros serão necessários. Os biofilmes estiveram relacionados com pior qualidade de vida doença-específica pré-operatória NOSE e avaliação endoscópica (Lund-Kennedy), e melhores resultados endoscópicos. Nossos resultados sugerem que nos pacientes com uma melhora clínica significativa após a cirurgia, o biofilme representou um papel mais predominante na fisiopatologia da doença. Neste subgrupo, a cirurgia provavelmente removeu a quantidade de biofilme necessária para restaurar o desequilíbrio inflamatório na mucosaIntroduction: The pathogenesis of chronic rhinosinusitis with nasal polyps is not completely established and there are some explanations for this disease, such as superantigens, inflammatory imbalance and, more recently, biofilms. Objective: Evaluate the association of biofilms presence and chronic rhinosinusitis with nasal polyps. Evaluate outcomes after sinus surgery for chronic rhinosinusitis with nasal polyps according to the presence of biofilms. Methods: This is a University based-tertiary care center study. The first part was a case-control study that evaluated a group of 33 consecutive patients undergoing functional endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps and a control group of 27 patients undergoing septoplasty for nasal obstruction treatment. Mucosal samples were harvested intra-operatively for scanning electron microscopic examination to determine biofilms presence. The second part was a prospective study. Preoperative and follow up data were recorded, including standardized evaluations of disease-specific quality of life related to nasal obstruction and rhinosinusitis, of nasal endoscopy and sinus computer tomography scan. Statistical analysis was performed. For all statistical tests p=0.05 was considered significant. Results: Biofilms were found in 72.7% (24/33) of chronic rhinosinusitis with nasal polyps patients and in 48.1%(13/27) of septoplasty patients (Odds ratio = 2.87, CI95% from 0.9796 to 8.419, p=0.051). This was the first report to analyze the effect of biofilms in outcomes with standardized measures of a group of only chronic rhinosinusitis with nasal polyps patients. Biofilms were present in 72.4% (21/29) of these patients. Patients with biofilms had a statistically significant worst preoperative score related to nasal obstruction and nasal endoscopy, but a similar median sinusitis total score. Patients with biofilms presented better Lund-Kennedy outcome (-3[5]vs.-1[2],U=46.0,p=0.036), but the best endoscopic improvement might reflect the worst clinical preoperative status. These patients had worst outcomes in SNOT-20 (-0.75[1.15]vs.-1.30[1.32],U=69.0,p=0.21) and similar outcomes in NOSE(-55.0[50.0] vs. -60.0[50.0], U=81.0,p=0.67) and Lund-Mackay (-4[5]vs.-4[4]),U=75.5,p=0.49). Patients with biofilms presented better Lund-Kennedy outcome (p=0.036). There was a correlation among some QoL outcome scores in both groups. Conclusion: Biofilms were demonstrated to be present in patients undergoing functional endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps but also in controls. Although the prevalence was not significantly different, the extremely wide 95% confidence interval, which just crosses unity, suggests that a meaningful clinical difference may have been missed because of low statistical power and that further study is necessary. Biofilms were related with worst preoperative disease-specific quality of life questionnaire (NOSE) and endoscopic evaluation (Lund-Kennedy), and better endoscopic outcome. Our findings suggest that in patients with a significant clinical improvement after surgery, the biofilm had a more predominant role in the pathophysiology of the disease. In this subgroup, the surgery probably removed the amount of biofilms needed to restore the mucosal inflammatory imbalance
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Ahmed, Shahzada Khuram. "Angiogenesis in the nasal mucosa." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4032/.
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Nasal polyposis is a common disease affecting 2-4% of the general population. The aetiology and pathogenesis are far from clear. Recent publications have suggested up-regulation of several pro-angiogenic factors including VEGF. The aim of this study was to assess and quantify the degree of angiogenesis in nasal polyposis and to determine if angiogenesis was the driving force behind polyposis. We started by developing a novel triple stain to assess remodelling in the nasal mucosa. For the first time we were able to categorically refute the common belief of angiogenesis driven polyposis. We then carried out genomic studies and identified upregulation of genes controlling the cell cycle and apoptosis, suggesting cell turnover is an important part of the pathogenesis of nasal polyps. Our gene expression data was confirmed by TUNEL staining, indicating an increased level of apoptosis in nasal polyp tissue, counterbalancing the increased cell proliferation. Inflammatory genes are also upregulated, however the data collected so far cannot distinguish between different types of inflammatory response. We carried out proteomic studies using the lu minex system but this did not clarify the situation despite using matched samples that were used in the gene array. They highlight the protein differences occurring in the polyps themselves. We have shown chemoattractants for eosinophils & macrophages (which are found in polyps), and significantly in iNOS, which is novel.
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Lindbom, John. "Phospholipase A₂ expression in the human nasal mucosa /." Linköping : Univ, 2004. http://www.bibl.liu.se/liupubl/disp/disp2004/med864s.pdf.
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Bai, Xue-Feng. "Modulation of experimental T cell autoimmunity in the nervous system with emphasis on nasal tolerance /." Stockholm, 1998. http://diss.kib.ki.se/1998ki/19980116baix.
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Harries, Helen Elizabeth. "Antibodies in the nasal mucosa : implications for allergic rhinitis." Thesis, King's College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582540.
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Allergic rhinitis is the outcome of an IgE-mediated allergic response in the nose. Previous studies of IgE produced by B-cells in the nasal mucosa of allergic rhinitis patients have shown an increased usage of the V H5 gene family, compared to the normal blood V H gene repertoire, which has been attributed to superantigen activity. Work reported in this thesis has been undertaken to investigate further how the antibody repertoire is shaped in allergic rhinitis. IgA-expressing B-cells in the nasal mucosa, from allergic and non-allergic donors, were also shown to have an increased usage of VH5 genes compared to the normal blood repertoire, suggesting the nasal environment favours VH5 expansion prior to allergy development. Somatic hypermutation patterns in VH5-Ca sequences were indicative of superantigen selection. FACS analysis of nasal turbinate cells with antibodies to S. aureus enterotoxins (SE) demonstrated TSST -1 + cells in allergic nasal tissue only. Incubation of nasal turbinate tissue with SEs appeared not to influence the VH-Cϵ repertoire in 24 hours, but SED + IL-4 may have inhibited VH-Cϵ transcription in allergic patients. Evidence of local antigen stimulation prior to SE incubation was evident in one of the patients; a large VH5 clonal family exhibiting extensive somatic hypermutation was present throughout the nasal turbinate. FACS sorting of Phl pl-binding plasma cells and single cell RT-PCR enabled cloning of a scFv fragment representing the V regions of a physiological, allergen-specific antibody expressed in allergic nasal mucosa. The scFv cloning protocol has also been applied to VH5 genes of interest, thus facilitating the study of their protein structure and function. This research increases the evidence for local, VH5-selecting, superantigen activity in the nasal mucosa and has developed a platform for further investigation of nasal antibody- superantigen / allergen interactions in allergic rhinitis.
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Tjahjono, Richard. "Correlation Between Nasal Mucosal Temperature Change and Perception of Nasal Patency." Thesis, University of Sydney, 2021. https://hdl.handle.net/2123/25547.
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Introduction – Nasal airway obstruction (NAO) is a common presentation that remains poorly understood. Recent evidence suggests that nasal mucosal temperature change, rather than airflow detection, is the primary determinant of subjective nasal patency. Thus, this study aims to examine the role of nasal mucosal temperature in the perception of nasal patency using computational fluid dynamics (CFD).
Methodology – Healthy adult participants were recruited. Participants completed Nasal Obstruction Symptom Evaluation (NOSE) and Visual Analogue Scale (VAS) questionnaires. A temperature probe was used to measure nasal mucosal temperature at the vestibule, inferior and middle turbinates, and nasopharynx bilaterally. Participants underwent a CT scan of the paranasal sinuses, which was used to create 3D computer models of nasal anatomy to perform CFD analysis of airflow and heat transfer during inspiration.
Results – Eleven participants (6 females, 54.5%) with a median age of 27 (IQR 24; 48) were recruited. No significant differences were seen in mean nasal mucosal temperature measurements obtained from temperature probe and CFD analysis (p = >0.05 for all locations). A statistically significant positive correlation was seen between higher nasal mucosal temperature and unilateral VAS, strongest at the left nasopharynx (Pearson r = 0.62; p = 0.019). A statistically significant negative correlation was seen between peak heat flux obtained from CFD simulations and unilateral VAS, stronger on the right side (Pearson r = -0.29; p = 0.0079). No statistically significant correlations were seen between wall shear stress, inspiratory nasal airway resistance or minimum cross-sectional area with unilateral VAS.
Conclusion – Lower nasal mucosal temperature and higher heat flux within the nasal cavity correlates with a perception of improved nasal patency in healthy individuals. CFD simulations may prove to be a valuable modality in improving the assessment and management of patients with NAO.
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王敏 and Min Wang. "Control of vascular reactivity of the nasal circulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31241153.
Full textBooks on the topic "Mucosa nasale"
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Stubbs, Donald Orok. Dental characteristics associated with nasal obstruction due to nasal mucosal swelling. [Toronto: Faculty of Dentistry, University of Toronto], 1989.
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Drake-Lee, A. B. Nasal mast cells: A preliminary report on their ultrastructure. Ashford, Kent: Headley Brothers, 1987.
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Eriksson, Catarina. Herbicide-induced toxicity in the nasal olfactory mucosa: Studies on Dichlobenil and Chlorthiamid. Uppsala: Sveriges Lantbruksuniversitet, 1995.
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King, William Phillip. A cephalometric study of a sample of male children with chronic nasal mucosal swelling. [Toronto: s.n.], 1987.
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AWARE, Oregon, and Oregon. Office of Disease Prevention and Epidemiology., eds. Runny nose (green or yellow mucus) =: Descarga nasal (mucosidad verde o amarilla). Portland, OR: Oregon AWARE, Oregon Dept. of Human Services, Office of Disease Prevention & Epidemiology, 2003.
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Division, Medicode (Firm) Med-Index, ed. Midface--sinus & nasal mucosa. Salt Lake City, UT: Medicode, Med-Index Division, 1994.
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Medicode. Midface--Sinus & Nasal Mucosa (Coding Illustrated). Ingenix - Sta/Medicode, 1995.
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1948-, Hsieh Dean, ed. Drug permeation enhancement: Theory and applications. New York: M. Dekker, 1994.
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Reintjes, Staci, and Susie Peterson. Rhinosinusitis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0012.
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Rhinosinusitis is inflammation of the nasal passages and paranasal sinuses, commonly caused by allergies or viral infection. Sinusitis occurs after the development of rhinitis or inflammation of the nasal passages. Rhinitis is most commonly caused by allergens, but it also can be to the result of an infectious or autoimmune process. For rhinitis to progress to rhinosinusitis, there must be obstruction within the ostiomeatal complex, which is the draining center for the maxillary, anterior ethmoid, and frontal sinuses. History and physical exam are more specific than imaging for diagnosis. Complications arising from sinusitis can cause extensive morbidity if not recognized early. The most common complication is periorbital cellulitis arising from ethmoidal sinusitis. Evaluate for severe complications in immunocompromised patients. Adjunctive therapies to relieve nasal obstruction include medications that decrease mucosal edema as well as increase clearance of congestion. Consider avoiding antibiotics if symptoms are of short duration and are consistent with viral sinusitis.
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Johnson, Nicholas J., and Judd E. Hollander. Management of cocaine poisoning. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0324.
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Cocaine is powerful central nervous system (CNS) stimulant derived from the coca plant. It affects the body via a number of mechanisms including blockade of fast sodium channels, increased catecholamine release, inhibition of catecholamine reuptake, and increased concentration of excitatory amino acid concentrations in the CNS. It is rapidly absorbed via the aerodigestive, respiratory, gastrointestinal, and genitourinary mucosa, and also may be injected. When injected intravenously or inhaled, cocaine is rapidly distributed throughout the body and CNS, with peak effects in 3–5 minutes. With nasal insufflation, absorption peaks in 20 minutes. Its half-life is approximately 1 hour. Common clinical manifestations include agitation, euphoria, tachycardia, hyperthermia, and hypertension. Chest pain is a common presenting complaint among cocaine users; 6% of these patients will have myocardial infarction. Other life-threatening sequelae include stroke, intracranial haemorrhage, seizures, dysrhythmias, and rhabdomyolysis. Clinical signs and symptoms, as well as severity of intoxication, should dictate the diagnostic evaluation and treatment of cocaine intoxicated patients. If the patient has chest pain, an ECG, chest radiograph, and measurement of cardiac biomarkers should be performed. A brief observation period may be useful in these patients. Many manifestations of cocaine intoxication, including agitation, hypertension, and chest pain, are effectively treated with benzodiazepines. Beta-blockers should be avoided in patients with suspected cocaine intoxication. Special attention should be paid to pregnant patients and those who present after ingesting packets filled with cocaine, as they may exhibit severe toxicity if these packets rupture.
Book chapters on the topic "Mucosa nasale"
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Riley, David S. "Mucosa nasalis." In Materia Medica of New and Old Homeopathic Medicines, 127–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-25292-1_42.
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Riley, David S. "Mucosa nasalis suis." In Materia Medica of New and Old Homeopathic Medicines, 163–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-54192-0_47.
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Riley, David S., and Ashley Ross. "Mucosa nasalis suis." In Materia Medica of New and Old Homeopathic Medicines, 181–82. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-65920-2_54.
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Kerns, William D. "Polypoid Adenoma, Nasal Mucosa, Rat." In Respiratory System, 41–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-96846-4_5.
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Bitter, Christoph, Katja Suter-Zimmermann, and Christian Surbera. "Nasal Drug Delivery in Humans." In Topical Applications and the Mucosa, 20–35. Basel: KARGER, 2011. http://dx.doi.org/10.1159/000321044.
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Yuba, Eiji, and Kenji Kono. "Nasal Delivery of Biopharmaceuticals." In Mucosal Delivery of Biopharmaceuticals, 197–220. Boston, MA: Springer US, 2014. http://dx.doi.org/10.1007/978-1-4614-9524-6_8.
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Armstrong, Michelle, Shonagh Walker, Jenifer Mains, and Clive G. Wilson. "Drug Delivery Across the Nasal Mucosa." In Mucoadhesive Materials and Drug Delivery Systems, 61–82. Chichester, United Kingdom: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118794203.ch03.
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Kerns, William D. "Squamous Cell Carcinoma, Nasal Mucosa, Rat." In Respiratory System, 54–61. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-96846-4_7.
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Shimizu, Takeshi. "Mucus, Goblet Cell, Submucosal Gland." In Nasal Physiology and Pathophysiology of Nasal Disorders, 1–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-37250-6_1.
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Shimizu, Takeshi. "Mucus, Goblet Cell, Submucosal Gland." In Nasal Physiology and Pathophysiology of Nasal Disorders, 1–14. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-12386-3_1.
Full textConference papers on the topic "Mucosa nasale"
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Nierkamp, I., B. Abbaspour, K. Stübke, A. Beule, and C. Rudack. "Detection of cannabinoide receptors 1 and 2 in human nasale mucosa – a pilot study." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686737.
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Jia, Yanlin, Gissela Lieber, Robbie L. McLeod, and John Anthes. "Corticosteroids Induce Vasoconstriction In Porcine Nasal Mucosa." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2778.
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Schmitz, P., and G. Strauß. "Effects of regeneration factors in nasal mucosa dysfunctions." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640904.
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Sooklal, Valmiki, Jesse McClure, Luke Hooper, and Michael Larson. "A laser device for fusion of nasal mucosa." In BiOS, edited by Nikiforos Kollias, Bernard Choi, Haishan Zeng, Reza S. Malek, Brian J. Wong, Justus F. R. Ilgner, Kenton W. Gregory, et al. SPIE, 2010. http://dx.doi.org/10.1117/12.843854.
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Zhu, Rui, Ryan Owen, Tracy Staton, Kun Peng, Catherine Huang, Meire Bremer, Neeka Meshgin, Prajna Banerjee, Rebecca Bauer, and Fang Cai. "Characterization of omalizumab partitioning in the nasal mucosa of patients." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa1657.
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Silva, Gizele Alves da, Eduardo Almeida de Souza Minuzzo, Gizele Alves da Silva, Renata de Santana Lima, Kallyto Amorim Costa, and Christovam Abdalla Neto. "EFEITOS ADVERSOS DA ANFOTERICINA B CONTRAPONDO- SE À ADESÃO AO TRATAMENTO DA LEISHMANIOSE TEGUMENTAR." In II Congresso Brasileiro de Parasitologia Humana On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/conbrapah/28.
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Introdução: A leishmaniose tegumentar americana e uma doença infecciosa que acomete a pele e as mucosas do nariz, da boca, da faringe e da laringe. É causada por protozoários do gênero Leishmania e transmitida por insetos conhecidos genericamente como flebotomíneos. Objetivo: Relatar o caso de um paciente reinfectado por leishmaniose tegumentar em tratamento com anfotericina B, que apresentou reações adversas: edema em face, membros inferiores, dor em hipocôndrio direito, ganho de peso, febre esporádica, poliúria, alteração da coloração da urina e obstrução nasal. A partir das informações supracitadas, este estudo tem por escopo analisar a influência das reações adversas na adesão ao tratamento. Materiais e métodos: Paciente do sexo masculino, 46 anos de idade, natural de Redenção – PA, garimpeiro, compareceu ao Centro de Especialidades e Reabilitação, com queixa de “reação ao medicamento para leish”. O mesmo foi diagnosticado com leishmaniose tegumentar em 2019 e realizou tratamento com antimoniato de N-metilglucamina. Resultados: Em setembro de 2020 apresentou reinfecção, iniciando o tratamento com Anfotericina B em maio de 2021 e no atendimento informou que estava na 19ª dose do tratamento, porém cursando com edema em face e membros inferiores. Relata que após o início do tratamento teve ganho de peso, febre esporádica, poliúria, alteração da coloração da urina. Exame físico evidenciou eritema em mucosa nasal e lesão cicatricial sugestiva de leishmaniose tegumentar em mucosa labial, fígado palpável a 3 cm do rebordo costal com dor a palpação. Tais alterações levaram à suspensão da medicação. Conclusão: A adesão ao tratamento da leishmaniose com anfotericina B é fortemente influenciada pelos efeitos adversos. Podem surgir durante o processo terapêutico: hepatotoxicidade, insuficiência renal e/ou cardíaca, dispepsia, febre, dentre outros. Somado a isto, a relação médico- paciente, grau de escolaridade, causas estruturais e políticas públicas deficitárias implicam de forma direta no alto índice de abandono do tratamento. Nessa linha de raciocínio, ratifica-se que os efeitos adversos do medicamento interferem de forma negativa à adesão ao tratamento e, consequentemente, à cura, podendo levar ao surgimento de deformações e incapacitações.
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Slawinski, Piotr R., Weston M. Lewis, and Benjamin S. Terry. "Performance Assessment of a Noninvasive Swallowable Biosensor Deployment System in Microgravity." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-65039.
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Ingestible capsule endoscope technology has been a topic of research since the middle of the 20th century and has become a prominent area of study since the commercialization of capsule endoscopy in 2000. Ingestible telemetry capsules have been investigated by NASA in the last 20 years as a means for monitoring human body temperature during periods of physical exhaustion, but are limited in sensing time due to passage through the digestive system. In this work, we present a feasibility study on a sensor that attaches to the intestinal mucosa after being delivered to the bowel via ingestible capsule to be used on long distance space flights. This study included experiments conducted on NASA’s Weightless Wonder aircraft and replicated in a laboratory setting on the ground. During these experiments, a capsule was activated, manually inserted into excised porcine small intestine, and then automatically implanted a sham sensor onto the mucosal lining. The purpose of the experiment was to determine if the automated implantation sequence is affected by microgravity. Eight trials conducted in each setting yielded successful implantation of four sham sensors in microgravity and three in earth gravity. Results suggest that automated implantation is feasible in both 1G and microgravity environments though design changes are necessary to significantly improve repeatability in both environments. Though improvements in reliability of the device are needed, this experiment is a benchmark for transferring capsule technology currently used only for visual screening of the bowel to health monitoring systems for space flights.
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Taylor, Donal J., Denis J. Doorly, and Robert C. Schroter. "Airflow in the Human Nasal Cavity: An Inter-Subject Comparison." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206459.
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The human nose is a remarkably complicated biological conduit that plays a significant, perpetual role in respiratory defense and olfaction. It is not a passive organ and has evolved to balance many conflicting requirements, while processing 10,000 litres of inspired air in a typical day [1]. The highly vascularised nasal mucosa heats and humidifies adjacent airflow, whilst the nasal mucosa collects nearly all particles over 5 μm diameter and approximately 50% of those between 2–4 μm [1]. Furthermore, the nasal airways house the olfactory apparatus, which enables humans to sense (smell) the external environment. The research presented here incorporates Computational Fluid Dynamics (CFD) in conjunction with experimental optical measurement techniques to resolve the patterns of flow within the nasal airways of two healthy subjects. This abstract details the experimental and computational methodologies used to simulate constant inspiration at a rate of 100 ml.s−1, which is representative of quiet restful breathing. The results presented focus on a comparison of the upper airway flow distributions in both subjects.
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Neto, João Augusto Dugim, Thainá Galvão Nunes, Nathali Da Câmara Hurtado, Jaqueline Ramos De Farias, and Renan Souto Terra. "TUMOR VENÉREO TRANSMISSÍVEL NASAL: RELATO DE CASO." In I Congresso On-line Nacional de Clínica Veterinária de Pequenos Animais. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1885.
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Introdução: O Tumor Venéreo Transmissível (TVT) é uma neoplasia benigna de células redondas que podem afetar cães de ambos os sexos. Ocorre através do contato direto a partir da cópula ou lambedura, acometendo principalmente a mucosa genital externa desses animais, além das cavidades nasal ou oral, pele e reto. Objetivos: Relatar um caso de TVT de um cão, caracterizando a patologia com destaque no diagnóstico e tratamento. Material e métodos: Um cachorro da raça pitbull, fêmea, 2 anos, inteira, resgatada, foi atendida na Clínica Veterinária Tostes, Niterói/RJ, apresentando lesões na região da face, anorexia, mucosas hipocoradas, prostração, dispneia, epistaxe, descarga nasal, espirros e escore de condição corporal abaixo do padrão de normalidade. Foi realizado hemograma completo e citologia da região, observando-se anemia normocítica normocrômica, leucocitose, trombocitopenia, neutrofilia, monocitose e eosinopenia absolutas. Ademais, foram enviadas quatro lâminas de lesão em focinho para avalição citológica, certificando-se na análise: presença de células redondas com alta relação núcleo:citoplasma, anisocariose e anisocariose discretas, citoplasma moderadamente basofílico e núcleo de cromatina frouxa e 1 a 2 nucléolos, o que se constatou tratar de tumor venéreo transmissível. Resultados: No caso clínico apresentado, o animal por não ser castrado e não domiciliado, encontrava-se susceptível a apresentar a doença, pois essa enfermidade acomete mais frequentemente animais com estas características. O tratamento foi realizado com a aplicação endovenosa na dose de 0,025mg/kg de sulfato de vincristina, uma vez por semana, durante quatro semanas. Houve uma considerável diminuição do tamanho da lesão neoplásica do animal, com cessão da hemorragia, do ronco e dos espirros, além da melhora na respiração por redução do tecido tumoral presente na cavidade nasal. Conclusão: O protocolo terapêutico realizado obteve sucesso na regressão do tumor e o TVT apesar de ser uma neoplasia comumente benigna, pode apresentar histopatologicamente características malignas e possui tratamento. Os cães mais acometidos são os classificados como semi-domiciliados e comunitários, tendo em vista que esses animais possuem maior predisposição por estarem em contato com outros cães em situações ambientais e sanitárias desfavoráveis. Sendo assim, torna-se imprescindível que haja um controle populacional, minimizando as chances de propagação entre os mesmos.
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Barbero, Juan M. Revuelta, Roberto M. Soriano, Rima S. Rindler, David P. Bray, Eduardo J. Medina, Edoardo Porto, Emily Barrow, Clementino A. Solares, and Gustavo Pradilla. "Purely Nasal Floor Mucosa Free Graft for EEA Transellar Postoperative Defects." In 31st Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1743981.
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