Journal articles: 'MtProC'

1

Zhao, Jian-Hong, Jiang-Huai Chen, Yong Wang, Zhi-Ping Wang, and Yong-Xing He. "The putative compatible solute-binding protein ProX fromMycobacterium tuberculosisH37Rv: biochemical characterization and crystallographic data." Acta Crystallographica Section F Structural Biology Communications 74, no. 4 (March 23, 2018): 231–35. http://dx.doi.org/10.1107/s2053230x18003771.

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InMycobacterium tuberculosis, theproXgene encodes a putative compatible solute-binding protein (MtProX). However, it was found through sequence alignment that the MtProX protein has very different ligand-binding residues compared with other compatible solute-binding proteins, implying that MtProX may bind to ligands that are as yet uncharacterized. In this work, it was demonstrated that MtProX binds to polyphenols such as phloretin, monoacetylphloroglucinol and 2,4-dihydroxyacetophloroglucinol with dissociation constants between 20 and 70 µM. Crystals of MtProX were obtained using a precipitant consisting of 0.2 MNaCl, 0.1 MTris pH 8.5, 25%(w/v) polyethylene glycol 3350. The crystals diffracted to 2.10 Å resolution and belonged to space groupP43212, with unit-cell parametersa=b= 90.17,c= 161.92 Å, α = β = γ = 90.0°. Assuming the presence of two MtProX molecules in the asymmetric unit, the Matthews coefficient was calculated to be 2.74 Å3 Da−1, which corresponds to a solvent content of 55%.

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Zhang, Yifei, Longzhi Zhao, Tianming Zhao, Lu Liu, and Lijun Xu. "Aeroacoustics Analysis of Propeller Blades." Journal of Physics: Conference Series 2569, no. 1 (August 1, 2023): 012026. http://dx.doi.org/10.1088/1742-6596/2569/1/012026.

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Abstract Under rapid development, drone propellers are facing two essential problems: noise emission and aerodynamic efficiency. In this work, the aeroacoustics characteristics of two propellers were experimentally and numerically investigated. Both propellers have exactly the same design points, and MTprop-1678 has a thinner blade and larger chord than MTprop-1688. Results showed that the broadband noise of 1678 significantly rose due to a larger Reynolds number, and the total noise was larger. The study shows that reducing the Reynolds number might be a good idea for propellers’ noise reduction.

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Wu, Hongyan, Xinying Ao, Jianan Liu, Junya Zhu, Jingran Bi, Hongman Hou, Hongshun Hao, and Gongliang Zhang. "Functional Chitosan-Based Composite Film Incorporated with 3-(Methylthio) Propyl Isothiocyanate/α-Cyclodextrin Inclusion Complex for Chicken Meat Preservation." Polymers 14, no. 21 (November 1, 2022): 4655. http://dx.doi.org/10.3390/polym14214655.

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The 3-(Methylthio) propyl isothiocyanate (MTPITC)-loaded inclusion complex prepared by α-cyclodextrin (α-CD) was incorporated into chitosan (CS) film to fabricate a packaging material for fresh chicken meat preservation. Scanning electron microscope images indicated homogenous dispersion of the MTPITC-α-CD in CS polymer. Fourier-transform infrared and X-ray diffraction techniques revealed that MTPITC-α-CD was incorporated into the CS film matrix by the physical interactions. The introduction of MTPITC-α-CD improved the UV-vis light-blocking ability, with a slight loss of transparency. Although the water solubility and water vapor barrier capacity were not significantly influenced by the addition of MTPITC-α-CD, the antioxidant attribute was significantly enhanced. The CS-MTPITC-α-CD film displayed obvious and sustained suppressive effects against Salmonella typhimurium, with the inhibition zone diameters of 14.7 mm at 12 h and 7.3 mm at 24 h, respectively. Moreover, the quality index analysis indicated that the CS-MTPITC-α-CD film-wrapped fresh chicken, during refrigerated storage, exhibited better preservative efficacy than the control groups, with the total viable counts of 6.5 Log CFU/g, total volatile base nitrogen of 8.4 mg/100 g, pH of 6.6, thiobarbituric acid-reactive substances of 0.2 mg/kg, and the sensory score of 5 at day 16. Collectively, these results suggest that CS-MTPITC-α-CD film is a prospective packaging candidate for delaying the quality deterioration of chicken meat.

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Tang, Su, Nathan D. Hicks, Yu-Shan Cheng, Andres Silva, Sarah M. Fortune, and James C. Sacchettini. "Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor." Nucleic Acids Research 47, no. 18 (August 26, 2019): 9934–49. http://dx.doi.org/10.1093/nar/gkz724.

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Abstract The pathogenicity of Mycobacterium tuberculosis depends upon its ability to catabolize host cholesterol. Upregulation of the methylcitrate cycle (MCC) is required to assimilate and detoxify propionyl-CoA, a cholesterol degradation product. The transcription of key genes prpC and prpD in MCC is activated by MtPrpR, a member of a family of prokaryotic transcription factors whose structures and modes of action have not been clearly defined. We show that MtPrpR has a novel overall structure and directly binds to CoA or short-chain acyl-CoA derivatives to form a homotetramer that covers the binding cavity and locks CoA tightly inside the protein. The regulation of this process involves a [4Fe4S] cluster located close to the CoA-binding cavity on a neighboring chain. Mutations in the [4Fe4S] cluster binding residues rendered MtPrpR incapable of regulating MCC gene transcription. The structure of MtPrpR without the [4Fe4S] cluster-binding region shows a conformational change that prohibits CoA binding. The stability of this cluster means it is unlikely a redox sensor but may function by sensing ambient iron levels. These results provide mechanistic insights into this family of critical transcription factors who share similar structures and regulate gene transcription using a combination of acyl-CoAs and [4Fe4S] cluster.

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Zhou, Ninglin, Xiao Xian Xia, Li Li, Shao Hua Wei, and Jian Shen. "Studies on Nanostructured Polyurethane/Clay Interpenetrating Polymer Networks." Materials Science Forum 475-479 (January 2005): 1001–4. http://dx.doi.org/10.4028/www.scientific.net/msf.475-479.1001.

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A novel exfoliated polyurethane (PU)/clay Interpenetrating Polymer Networks (IPNs) nanocomposite has been synthesized with polyurethane and organoclay. MTPAC is used as swelling agent to treat Na-montmorillonite for forming organoclay. The results indicate that there is very good compatibility between organoclay and PU. Nanoscale silicate dispersion was analyzed by XRD. The mechanical properties of the nanocomposites have been measured by tensile testing machine. The nanocomposites show obviously improved physical and mechanical properties when compared with the pure polymer. Additionally, PU /MTPAC- clay shows lower water absorption properties than pure PU do. In addition, the reinforcing and intercalating mechanism of silicate layers in polyurethane matrix are discussed.

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Krüner, Simon, and Christoph Hackl. "Experimental Identification of the Optimal Current Vectors for a Permanent-Magnet Synchronous Machine in Wave Energy Converters." Energies 12, no. 5 (March 5, 2019): 862. http://dx.doi.org/10.3390/en12050862.

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This paper investigates efficiency enhancements in Permanent-Magnet Synchronous Machines (PMSMs) used as generators in wave energy converters. A method is presented, which allows experimental identification of the optimal current vectors leading to minimal losses and maximum efficiency. Iron and inverter losses are considered. The proposed identification method is generic and is applicable to any PMSM used as a generator. The obtained results are compared to the well-known Maximum Torque per Current (MTPC) strategy. Two MTPC strategies are investigated: (i) MTPC using linearised flux linkages; and (ii) MTPC using measured, nonlinear flux linkages. For both MTPC strategies, the influence of the Voltage Source Inverter (VSI) is taken into account. All measurements are performed on a simple and cheap industrial-like test bench. All three presented methods lead to increased efficiency. The best efficiency is obtained by the proposed maximum efficiency strategy, where iron and inverter losses are taken into account by proper measurement of the optimal current vectors.

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Chen, Zhen, Changqing Feng, Haolei Chen, Ruirui Fan, Han Yi, Jiaqi Wang, and Shubin Liu. "An SCA ASIC-based multi-channel readout system for a prototype multi-purpose TPC at CSNS Back-n white neutron source." Journal of Physics: Conference Series 2374, no. 1 (November 1, 2022): 012080. http://dx.doi.org/10.1088/1742-6596/2374/1/012080.

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The back-streaming white neutron source (Back-n) at China Spallation Neutron Source (CSNS), which has excellent energy spectrum and good time resolution, provides superior conditions for neutron induced light charged particle tracking experiment. To track light charged particles, CSNS has proposed a project named Multi-purpose Time Projection Chambers (MTPC) and completed a 1519-channel prototype. A multi-channel readout system based on Switched Capacitor Arrays (SCA) waveform sampling ASIC was designed to meet the requirements of the prototype MTPC. This paper presents the structure of this readout system and the results of the beam test with MTPC at CSNS. Time of Flight spectrum of neutron beam and 3D-track of neutron induced light charged particles were successfully reconstructed. These test results prove the feasibility of large-scale MTPC.

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Hsu, Ling-Yuan, Shi-Jinn Horng, Pingzhi Fan, Muhammad Khurram Khan, Yuh-Rau Wang, Ray-Shine Run, Jui-Lin Lai, and Rong-Jian Chen. "MTPSO algorithm for solving planar graph coloring problem." Expert Systems with Applications 38, no. 5 (May 2011): 5525–31. http://dx.doi.org/10.1016/j.eswa.2010.10.084.

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9

Chen, Percival Yang-Ting, Heather Aman, Mehmet Can, Stephen W. Ragsdale, and Catherine L. Drennan. "Binding site for coenzyme A revealed in the structure of pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica." Proceedings of the National Academy of Sciences 115, no. 15 (March 26, 2018): 3846–51. http://dx.doi.org/10.1073/pnas.1722329115.

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Pyruvate:ferredoxin oxidoreductase (PFOR) is a microbial enzyme that uses thiamine pyrophosphate (TPP), three [4Fe-4S] clusters, and coenzyme A (CoA) in the reversible oxidation of pyruvate to generate acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism, including the Wood–Ljungdahl pathway. PFOR is a member of the 2-oxoacid:ferredoxin oxidoreductase (OFOR) superfamily, which plays major roles in both microbial redox reactions and carbon dioxide fixation. Here, we present a set of crystallographic snapshots of the best-studied member of this superfamily, the PFOR from Moorella thermoacetica (MtPFOR). These snapshots include the native structure, those of lactyl-TPP and acetyl-TPP reaction intermediates, and the first of an OFOR with CoA bound. These structural data reveal the binding site of CoA as domain III, the function of which in OFORs was previously unknown, and establish sequence motifs for CoA binding in the OFOR superfamily. MtPFOR structures further show that domain III undergoes a conformational change upon CoA binding that seals off the active site and positions the thiolate of CoA directly adjacent to the TPP cofactor. These structural findings provide a molecular basis for the experimental observation that CoA binding accelerates catalysis by 105-fold.

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10

D’Souza, Malcolm J., Zoon Ha Ryu, Byoung-Chun Park, and Dennis N. Kevill. "Correlation of the rates of solvolysis of acetyl chloride and α-substituted derivatives." Canadian Journal of Chemistry 86, no. 5 (May 1, 2008): 359–67. http://dx.doi.org/10.1139/v08-028.

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Additional specific rates of solvolysis have been determined for acetyl chloride and diphenylacetyl chloride. These are combined with literature values to carry out correlation analyses, using the extended Grunwald–Winstein equation with incorporation of literature values for solvent nucleophilicity (NT) and solvent ionizing power (YCl). Parallel analysis are carried out using literature values for the specific rates of solvolysis of trimethylacetyl chloride, chloroacetyl chloride, phenylacetyl chloride, and α-methoxy-α-trifluoromethylphenylacetyl chloride (MTPAC). Chloroacetyl chloride and MTPAC react by an addition-elimination pathway, with the addition step rate-determining, over the full range of solvents. Acetyl chloride reacts over the full range of solvents by an ionization pathway, with considerable nucleophilic solvation. The other three substrates can solvolyze with the domination of either mechanism, depending on the properties of the solvent. Reports concerning the use of product selectivity values, kinetic solvent isotope effects, and computational studies as additional probes of the mechanism of solvolysis are discussed.Key words: Grunwald-Winstein equation, acyl chlorides, mechanism of solvolysis, solvent nucleophilicity.

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11

Liu, Jianan, Hongyan Wu, Xinying Ao, Hongshun Hao, Jingran Bi, Hongman Hou, and Gongliang Zhang. "Characterization of the Inclusion Complexes of Isothiocyanates with γ-Cyclodextrin for Improvement of Antibacterial Activities against Staphylococcus aureus." Foods 11, no. 1 (December 27, 2021): 60. http://dx.doi.org/10.3390/foods11010060.

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The aim of this study was to develop inclusions formed by γ-cyclodextrin (γ-CD) and three isothiocyanates (ITCs), including benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC), and 3-methylthiopropyl isothiocyanate (MTPITC) to improve their controlled release for the inhibition of Staphylococcus aureus (S. aureus). These inclusion complexes were characterized using X-ray diffraction, Fourier-transform infrared, thermogravimetry, and scanning electron microscopy (SEM), providing appropriate evidence to confirm the formation of inclusion complexes. Preliminary evaluation of the antimicrobial activity of the different inclusion complexes, carried out in vitro by agar diffusion, showed that such activity lasted 5–7 days longer in γ-CD-BITC, in comparison with γ-CD-PEITC and γ-CD-MTPITC. The biofilm formation was less in S. aureus treated with γ-CD-BITC than that of BITC by using crystal violet quantification assay and SEM. The expression of virulence genes, including sarA, agr, cp5D, cp8F, clf, nuc, and spa, showed sustained downregulation in S. aureus treated with γ-CD-BITC for 24 h by quantitative real-time polymerase chain reaction (qRT-PCR). Moreover, the growth of S. aureus in cooked chicken breast treated with γ-CD-BITC and BITC was predicted by the Gompertz model. The lag time of γ-CD-BITC was 1.3–2.4 times longer than that of BITC, and correlation coefficient (R2) of the secondary models was 0.94–0.99, respectively. These results suggest that BITC has a more durable antibacterial effect against S. aureus after encapsulation by γ-CD.

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Branscheid, Anja, Daniela Sieh, Bikram Datt Pant, Patrick May, Emanuel A. Devers, Anders Elkrog, Leif Schauser, Wolf-Rüdiger Scheible, and Franziska Krajinski. "Expression Pattern Suggests a Role of MiR399 in the Regulation of the Cellular Response to Local Pi Increase During Arbuscular Mycorrhizal Symbiosis." Molecular Plant-Microbe Interactions® 23, no. 7 (July 2010): 915–26. http://dx.doi.org/10.1094/mpmi-23-7-0915.

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Many plants improve their phosphate (Pi) availability by forming mutualistic associations with arbuscular mycorrhizal (AM) fungi. Pi-repleted plants are much less colonized by AM fungi than Pi-depleted plants. This indicates a link between plant Pi signaling and AM development. MicroRNAs (miR) of the 399 family are systemic Pi-starvation signals important for maintenance of Pi homeostasis in Arabidopsis thaliana and might also qualify as signals regulating AM development in response to Pi availability. MiR399 could either represent the systemic low-Pi signal promoting or required for AM formation or they could act as counter players of systemic Pi-availability signals that suppress AM symbiosis. To test either of these assumptions, we analyzed the miR399 family in the AM-capable plant model Medicago truncatula and could experimentally confirm 10 novel MIR399 genes in this species. Pi-depleted plants showed increased expression of mature miR399 and multiple pri-miR399, and unexpectedly, levels of five of the 15 pri-miR399 species were higher in leaves of mycorrhizal plants than in leaves of nonmycorrhizal plants. Compared with nonmycorrhizal Pi-depleted roots, mycorrhizal roots of Pi-depleted M. truncatula and tobacco plants had increased Pi contents due to symbiotic Pi uptake but displayed higher mature miR399 levels. Expression levels of MtPho2 remained low and PHO2-dependent Pi-stress marker transcript levels remained high in these mycorrhizal roots. Hence, an AM symbiosis-related signal appears to increase miR399 expression and decrease PHO2 activity. MiR399 overexpression in tobacco suggested that miR399 alone is not sufficient to improve mycorrhizal colonization supporting the assumption that, in mycorrhizal roots, increased miR399 are necessary to keep the MtPho2 expression and activity low, which would otherwise increase in response to symbiotic Pi uptake.

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13

Yalçın, Uğur, and Mücahit Sarnık. "Uniform Diffracted Fields from a Perfectly Conducting Cylindrical Reflector with Modified Theory of Physical Optics." Scientific World Journal 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/195402.

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The uniform diffracted fields are calculated on PEC cylindrical reflector by Modified Theory of Physical Optics (MTPO). It is aimed to convert the noncontinuous solution to a continuous solution by finding a uniform equation which does not contain any expression converging to 0 in the denominator part. Three axioms of MTPO theory are used to construct the integral equations for the perfectly electrically conducting surface application. The “edge-point” technique is used to find the diffracted field, and uniform solution is to be found via “detour parameter(s).” Finally, the obtained results are to be compared with the nonuniform ones, numerically.

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Nagy, Stanislaw, and Jakub Siemek. "Confined Phase Envelope of Gas-Condensate Systems in Shale Rocks." Archives of Mining Sciences 59, no. 4 (December 1, 2014): 1005–22. http://dx.doi.org/10.2478/amsc-2014-0069.

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Abstract Natural gas from shales (NGS) and from tight rocks are one of the most important fossil energy resource in this and next decade. Significant increase in gas consumption, in all world regions, will be marked in the energy sector. The exploration of unconventional natural gas & oil reservoirs has been discussed recently in many conferences. This paper describes the complex phenomena related to the impact of adsorption and capillary condensation of gas-condensate systems in nanopores. New two phase saturation model and new algorithm for search capillary condensation area is discussed. The algorithm is based on the Modified Tangent Plane Criterion for Capillary Condensation (MTPCCC) is presented. The examples of shift of phase envelopes are presented for selected composition of gas-condensate systems.

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Pietrzak, Mariusz, Joanna Buczyńska, Fritz Duus, Jacek Waluk, and Poul Erik Hansen. "Photoinduced and ground state conversions in a cyclic β-thioxoketone." RSC Advances 12, no. 2 (2022): 681–89. http://dx.doi.org/10.1039/d1ra09020h.

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Umul, Yusuf Z. "Rubinowicz transform of the MTPO surface integrals." Optics Communications 281, no. 23 (December 2008): 5641–46. http://dx.doi.org/10.1016/j.optcom.2008.08.008.

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Hsu, Ling-Yuan, Shi-Jinn Horng, Tzong-Wann Kao, Yuan-Hsin Chen, Ray-Shine Run, Rong-Jian Chen, Jui-Lin Lai, and I.-Hong Kuo. "Temperature prediction and TAIFEX forecasting based on fuzzy relationships and MTPSO techniques☆." Expert Systems with Applications 37, no. 4 (April 2010): 2756–70. http://dx.doi.org/10.1016/j.eswa.2009.09.015.

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Narumi, Ko, Motoyoshi Suzuki, Wenru Song, Malcolm A. S. Moore, and Ronald G. Crystal. "Intermittent, Repetitive Corticosteroid-Induced Upregulation of Platelet Levels After Adenovirus-Mediated Transfer to the Liver of a Chimeric Glucocorticoid-Responsive Promoter Controlling the Thrombopoietin cDNA." Blood 92, no. 3 (August 1, 1998): 822–33. http://dx.doi.org/10.1182/blood.v92.3.822.

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Abstract For many in vivo gene therapy clinical applications, it is desirable to control the expression of the transferred transgene using pharmacologic agents. To evaluate the feasibility of accomplishing this using corticosteroids, pharmacologic agents widely used in clinical medicine, we constructed replication deficient adenoviral (Ad) vectors containing an expression cassette with a chimeric promoter comprised of five glucocorticoid response elements (GRE) and the chloramphenicol acetyltransferase reporter gene (AdGRE.CAT) or the murine thrombopoietin cDNA (AdGRE.mTPO). In vitro studies showed the vectors functioned as expected, with marked glucocorticoid-induced upregulation of the CAT or mTPO transgenes. To evaluate the inducibility of the GRE promoter in vivo, the AdGRE.CAT vector was administered intravenously to C57B1/6 mice, and CAT activity was quantified in liver before and after intraperitoneal administration of dexamethasone. The GRE promoter activity was dependent on the dexamethasone dose, with a 100-fold increase in CAT expression with 50 μg dexamethasone, similar to the levels observed in vivo with the Rous sarcoma virus long terminal repeat constitutive promoter. After dexamethasone administration, maximum CAT activity was observed at day 2, with a slow decline to baseline levels by 2 weeks. Based on these observations, we hypothesized that a single administration of an Ad vector-mediated transfer of the chimeric GRE inducible promoter driving the mTPO cDNA would enable repetitive administration of corticosteroids to repetitively upregulate platelet levels for 1 to 2 weeks. The data show that this occurs, with dexamethasone administration every 3 weeks associated with 1-week elevations (at each 3-week interval) of serum mTPO levels, megakaryocyte numbers in bone marrow, and platelet levels fourfold to sixfold over baseline. Thus, with the appropriate promoter, it is possible to use a commonly used pharmacologic agent to upregulate the expression of a newly transferred gene on demand. © 1998 by The American Society of Hematology.

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Narumi, Ko, Motoyoshi Suzuki, Wenru Song, Malcolm A. S. Moore, and Ronald G. Crystal. "Intermittent, Repetitive Corticosteroid-Induced Upregulation of Platelet Levels After Adenovirus-Mediated Transfer to the Liver of a Chimeric Glucocorticoid-Responsive Promoter Controlling the Thrombopoietin cDNA." Blood 92, no. 3 (August 1, 1998): 822–33. http://dx.doi.org/10.1182/blood.v92.3.822.415a16_822_833.

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For many in vivo gene therapy clinical applications, it is desirable to control the expression of the transferred transgene using pharmacologic agents. To evaluate the feasibility of accomplishing this using corticosteroids, pharmacologic agents widely used in clinical medicine, we constructed replication deficient adenoviral (Ad) vectors containing an expression cassette with a chimeric promoter comprised of five glucocorticoid response elements (GRE) and the chloramphenicol acetyltransferase reporter gene (AdGRE.CAT) or the murine thrombopoietin cDNA (AdGRE.mTPO). In vitro studies showed the vectors functioned as expected, with marked glucocorticoid-induced upregulation of the CAT or mTPO transgenes. To evaluate the inducibility of the GRE promoter in vivo, the AdGRE.CAT vector was administered intravenously to C57B1/6 mice, and CAT activity was quantified in liver before and after intraperitoneal administration of dexamethasone. The GRE promoter activity was dependent on the dexamethasone dose, with a 100-fold increase in CAT expression with 50 μg dexamethasone, similar to the levels observed in vivo with the Rous sarcoma virus long terminal repeat constitutive promoter. After dexamethasone administration, maximum CAT activity was observed at day 2, with a slow decline to baseline levels by 2 weeks. Based on these observations, we hypothesized that a single administration of an Ad vector-mediated transfer of the chimeric GRE inducible promoter driving the mTPO cDNA would enable repetitive administration of corticosteroids to repetitively upregulate platelet levels for 1 to 2 weeks. The data show that this occurs, with dexamethasone administration every 3 weeks associated with 1-week elevations (at each 3-week interval) of serum mTPO levels, megakaryocyte numbers in bone marrow, and platelet levels fourfold to sixfold over baseline. Thus, with the appropriate promoter, it is possible to use a commonly used pharmacologic agent to upregulate the expression of a newly transferred gene on demand. © 1998 by The American Society of Hematology.

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20

Cao, Xiao-Man, Na Wei, Lin Liu, Li Li, and Zheng-Bo Han. "Luminescent lanthanide–organic polyrotaxane framework as a turn-off sensor for nitrobenzene and Fe3+." RSC Advances 6, no. 23 (2016): 19459–62. http://dx.doi.org/10.1039/c5ra25872c.

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Three isomorphous lanthanide–organic polyrotaxane frameworks [Ln(mtpc)_1.5(DMA)(H₂O)]·2H₂O [Ln = Tb (1); Dy (2); Er (3)] were assembled and characterized. 1 acts as a fluorescent probe for nitrobenzene and iron(iii) ions, and the detection limit of nitrobenzene is 15–150 ppm.

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Gamas, Pascal, Françoise de Billy, and Georges Truchet. "Symbiosis-Specific Expression of Two Medicago truncatula Nodulin Genes, MtN1 and MtN13, Encoding Products Homologous to Plant Defense Proteins." Molecular Plant-Microbe Interactions® 11, no. 5 (May 1998): 393–403. http://dx.doi.org/10.1094/mpmi.1998.11.5.393.

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Two Medicago truncatula nodulin genes putatively encoding proteins structurally related to two classes of proteins commonly associated with plant defense reactions have been characterized. MtN1 is homologous to two small, cysteine-rich, pathogen-inducible proteins from pea (pI39 and pI230), whereas MtN13 is closely related to the PR10 family of pathogenesis-related proteins. We show that neither MtN1 nor MtN13 is induced in leaves in response to pathogenic bacteria, and that both are exclusively expressed during nodulation. In situ hybridization experiments as well as Northern (RNA) studies of interactions between M. truncatula and either wild-type Rhizobium meliloti or mutants deficient in infection establish that MtN1 is associated with the infection process, while MtN13 represents the first specific marker described for the nodule outer cortex. Possible roles for MtN1 and MtN13 are discussed. We also present the identification of another member of the PR10 family, designated as MtPR10-1, whose regulation is strikingly different from that observed for MtN13, being constitutively expressed in roots and pathogen-inducible in leaves.

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Huang, Shaopo, Anmol Aggarwal, Elias G. Strangas, Bhuvan Khoshoo, Kui Li, and Feng Niu. "Mitigation of Interturn Short-Circuits in IPMSM by Using MTPCC Control Adaptive to Fault Severity." IEEE Transactions on Power Electronics 37, no. 4 (April 2022): 4685–96. http://dx.doi.org/10.1109/tpel.2021.3127538.

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Vir, Dharam. "Performance Analysis of Mtpr Routing Protocol in Power Deficient Node." International Journal on AdHoc Networking Systems 2, no. 4 (October 31, 2012): 67–75. http://dx.doi.org/10.5121/ijans.2012.2407.

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McKenzie, A. L., and P. H. Stevens. "Twenty-five years of MTPR-a theoretical and experimental analysis." Physics in Medicine and Biology 40, no. 1 (January 1, 1995): 17–29. http://dx.doi.org/10.1088/0031-9155/40/1/003.

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Umul, Yusuf Z. "MTPO based potential function of the boundary diffraction wave theory." Optics & Laser Technology 40, no. 6 (September 2008): 769–74. http://dx.doi.org/10.1016/j.optlastec.2008.01.011.

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Banu, N., JF Wang, B. Deng, JE Groopman, and H. Avraham. "Modulation of megakaryocytopoiesis by thrombopoietin: the c-Mpl ligand." Blood 86, no. 4 (August 15, 1995): 1331–38. http://dx.doi.org/10.1182/blood.v86.4.1331.bloodjournal8641331.

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We have further characterized the biological activities, mechanism of action, and target cell populations of recombinant human and murine thrombopoietin (rhTPO and rmTPO) in in vitro human and murine model systems. Alone, hTPO or mTPO stimulated the maturation of immature murine megakaryoblasts as measured in a single cell assay. The combination of hTPO or mTPO and interleukin-6 (IL-6) resulted in a further increase in megakaryocyte differentiation in this system. Murine TPO stimulated mouse megakaryocyte progenitor development. Human megakaryocyte progenitor development was potentiated by hTPO alone and further augmented in the presence of the early-acting cytokines (IL-3) or kit ligand/stem cell factor (KL/SCF). To further define the mechanism of action of TPO, neutralization studies were performed with antisera to IL-3, granulocyte-macrophage colony-stimulating factor (GM- CSF), IL-1 beta, and IL-11. No diminution in TPO activity was observed in the presence of these antisera. Moreover, because adhesive interactions are known to modulate hematopoiesis, we studied whether hTPO might alter such interactions between human bone marrow (BM) megakaryocytes and human BM stromal fibroblasts. No changes were observed in either megakaryocyte expression of the surface molecules lymphocyte function-associated antigen-1, very late activation antigen- 4, or intercellular adhesion molecule-1 or the adhesion of megakaryocytes to stromal fibroblasts after treatment with the growth factor. Furthermore, no induction of secretion of the cytokines IL-1 alpha, IL-1 beta, GM-CSF, IL-6, granulocyte-CSF, tumor necrosis factor- alpha, transforming growth factor-beta 1, or transforming growth factor- beta 2 by primary human BM megakaryocytes was noted after treatment of the cells with hTPO. To address whether TPO affects very primitive hematopoietic progenitors, we studied the residual cells from the BMs of mice treated with high doses of 5-fluorouracil. Although no effect of mTPO alone was noted on the viability or replication of such primitive murine progenitor populations, the triple combination of IL-3 + KL/SCF + TPO stimulated growth of megakaryocyte progenitors. These results indicate that TPO is a highly lineage-specific growth factor whose primary biological effects are likely to be direct modulation of the growth and maturation of committed megakaryocyte precursors and immature megakaryoblasts.

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Kong, Yiming, Yuxue Zhang, Xiu Liu, Zhe Meng, Xiaolin Yu, Chuanen Zhou, and Lu Han. "The Conserved and Specific Roles of the LUX ARRHYTHMO in Circadian Clock and Nodulation." International Journal of Molecular Sciences 23, no. 7 (March 23, 2022): 3473. http://dx.doi.org/10.3390/ijms23073473.

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LUX ARRHYTHMO (LUX) plays a key role in circadian rhythms and flowering. Here, we identified the MtLUX gene which is the putative ortholog of LUX in Medicago truncatula. The roles of MtLUX, in both the nodulation belowground and leaf movement aboveground, were investigated by characterizing a loss-of-function mtlux mutant. MtLUX was required for the control of flowering time under both long-day and short-day conditions. Further investigations showed that the early flowering in the mtlux mutant was correlated with the elevated expression level of the MtFTa1 gene but in a CO-like independent manner. MtLUX played a conserved role in the regulatory interactions with MtLHY, MtTOC1, and MtPRR genes, which is similar to those in other species. Meanwhile, the unexpected functions of MtLUX were revealed in nodule formation and nyctinastic leaf movement, probably through the indirect regulation in MtLHY. Its participation in nodulation is of interest in the context of functional conservation and the neo-functionalization of the products of LUX orthologs.

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Liu, Chenxi, Israel Cohen, Rotem Vishinkin, and Hossam Haick. "Nanomaterial-Based Sensor Array Signal Processing and Tuberculosis Classification Using Machine Learning." Journal of Low Power Electronics and Applications 13, no. 2 (May 29, 2023): 39. http://dx.doi.org/10.3390/jlpea13020039.

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Tuberculosis (TB) has long been recognized as a significant health concern worldwide. Recent advancements in noninvasive wearable devices and machine learning (ML) techniques have enabled rapid and cost-effective testing for the real-time detection of TB. However, small datasets are often encountered in biomedical and chemical engineering domains, which can hinder the success of ML models and result in overfitting issues. To address this challenge, we propose various data preprocessing methods and ML approaches, including long short-term memory (LSTM), convolutional neural network (CNN), Gramian angular field-CNN (GAF-CNN), and multivariate time series with MinCutPool (MT-MinCutPool), for classifying a small TB dataset consisting of multivariate time series (MTS) sensor signals. Our proposed methods are compared with state-of-the-art models commonly used in MTS classification (MTSC) tasks. We find that lightweight models are more appropriate for small-dataset problems. Our experimental results demonstrate that the average performance of our proposed models outperformed the baseline methods in all aspects. Specifically, the GAF-CNN model achieved the highest accuracy of 0.639 and the highest specificity of 0.777, indicating its superior effectiveness for MTSC tasks. Furthermore, our proposed MT-MinCutPool model surpassed the baseline MTPool model in all evaluation metrics, demonstrating its viability for MTSC tasks.

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Ramsey, Bryan C., Amy E. Field, Dustin M. Thomas, Christopher A. Pickett, Alisa J. Leon, and Bernard J. Rubal. "Assessment of Semi-automated Computed Tomographic Measures of Segmental Perfusion Defects in a Swine Model (Sus scrofa) of Intermediate Coronary Lesions." Comparative Medicine 70, no. 3 (June 1, 2020): 258–65. http://dx.doi.org/10.30802/aalas-cm-19-000104.

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Computed tomographic myocardial perfusion (CTP) imaging is a tool that shows promise in emergent settings for defining the hemodynamic significance of coronary artery disease. In this study, we examined the accuracy with which the transmural perfusion ratio (TPR) derived through semiautomated CTP analysis reflected segmental perfusion defects associated with intermediate coronary artery lesions in swine. Lesions (diameter stenosis, 65% ± 11%) of the left anterior descending coronary artery (LAD) were created in 10 anesthetized female swine (weight, 47.5 ± 1.9 kg) by using a pneumatic occlusion device implanted on the LAD. Occluder inflation pressures were adjusted to maintain fractional flow reserve (FFR, 74.3 ± 1.7) during adenosine infusion (140ug/kg/min). Static CTP imaging using a stress-rest protocol and segmental TPR derived from semiautomated CT perfusion software was compared with microsphere-derived TPR (mTPR) by using a 16-segment model and polar mapping. Intermediate LAD stenosis was verified through multiplanar coronary CT angiography. Receiver operating characteristic analysis identified an optimal threshold for segmental perfusion defects for intermediate lesions (TPR threshold, ≤0.80); however, the area under the receiver operating characteristic curve was 0.58, and the overall accuracy was 63%. At this threshold, the sensitivity and specificity were 65% and 61%, and the positive and negative predictive values were 61% and 65%, respectively. Although CTP–TPR illustrated segmental perfusion defects with intermediate lesions, the disparity between CTP–TPR and mTPR measures of segmental perfusion suggests that further advances in analysis software may be necessary to improve the localization of segmental defects for intermediated lesions.

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Umul, Yusuf Ziya. "The MTPO/Malyughinetz hybrid method for the scattering analysis of parabolic impedance reflectors." Optik 124, no. 22 (November 2013): 5577–84. http://dx.doi.org/10.1016/j.ijleo.2013.03.156.

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Lopes, Carmela, Mohammed Rachidi, Svetlana Gassanova, Pierre-Marie Sinet, and Jean-Maurice Delabar. "Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1." Mechanisms of Development 84, no. 1-2 (June 1999): 189–93. http://dx.doi.org/10.1016/s0925-4773(99)00076-3.

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Chatel-Soulet, Hugues-Etienne, Sabine Juge, Frederik Otzen Bagger, Alexandar Tzankov, Mineo Kurokawa, Jonathan Séguin, and Juerg Schwaller. "Modeling the Cellular Origin of EVI1 + MLL-AF9-Driven Acute Myeloid Leukemia (AML)." Blood 138, Supplement 1 (November 5, 2021): 2210. http://dx.doi.org/10.1182/blood-2021-149439.

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Abstract We previously reported that transplantation of hematopoietic stem cells (HSC) expressing a doxycycline (DOX)-regulated AML-associated MLL-AF9 fusion transgene can induce an invasive and chemoresistant disease in mice formed by tumour cells that express the transcription factor EVI1, a known marker of poor prognosis in AML and some solid cancers. To better understand the association of EVI1 and the cellular origin of the disease we analyzed Evi1-IRES-GFP reporter mice (female, n=8, 8-10 weeks old) and found that not only the, quiescent long-term hematopoietic stem cell (LT-HSC : lineage marker-negative (lin -) cKit +Sca1 +(= LSK), CD34 -CD135 -CD150 +CD48 -, 24±3.7%, n=8) compartment, but also more proliferating multipotent progenitors such as MPP1 (LSK, CD34 +CD135 -CD150 +CD48 -, 23±4.6%, n=8), MPP2 (LSK, CD34 +CD135 -CD150 +CD48 +, 6±2.3%, n=8) and MPP3 (LSK, CD34 +CD135 -CD150 -CD48 +, 2±1%, n=8) contain a significant number of cells that express abundant Evi1 ("Evi1 high") at steady state. Notably, we did not observe any significant changes in numbers of Evi1 + cells nor levels of Evi1 mRNA expression in the LT-HSC and MPP1 compartments 5 days after DOX-mediated induction of the iMLL-AF9 fusion. To address the impact of Evi1 on clonogenic growth of iMLL-AF9-expressing LT-HSC, we plated Evi1 high and Evi1 low naïve cells in methylcellulose (MC) and found that upon addition of DOX, Evi1 high cells formed more colonies with an invasive morphology ("type IV") compared to Evi1 low cells (n=11, p<0.05). Immunophenotypically, cells from Evi1 high cell-derived colonies retained a more immature phenotype, reflected by higher cKit +Sca1 + expression (n=11, p<0.05). Plated Evi1 high cells formed Evi1 + colonies whereas Evi1 low lost Evi1 expression (n=11, p<0.05). To address the differential transformation susceptibility in vivo, we transplanted identical numbers of naïve steady-state Evi1 + iMLL-AF9 LT-HSC and MPP1 into irradiated syngeneic recipients. While recipients of Evi1 + MPP1 cells developed an invasive AML earlier than Evi1 + LT-HSC-transplanted mice (n=27, median latency: 96.5 vs. 146.5d, n.s.), very similar disease phenotypes were observed. In contrast, transplants of Evi1 - MPP1 or LT-HSC resulted in a significantly delayed disease induction (n=31, median latency: >200d; LT-HSC: n.s.; MPP1: p<0.05). Although Evi1 + cell-induced disease did present with more extensive organ infiltration by leukemic blasts than Evi1 - AML the phenotypes were similar. We also wondered whether modulation of the HSC compartment by exogenous factors may change Evi1 expression and affect AML induction. We found that 2 days after a single injection (200mg/kg) of recombinant mouse thrombopoietin (mTPO) the number of LT-HSC (n=23; 647 vs. 1165/10 6 lin - cells, p<0.05), but not of MPP1, significantly increased. Similarly, a single application of the synthetic mTPO receptor agonist Romiplostim (RP, 200mg/kg) resulted after 48h in an increase of LT-HSC (n=14; 647 vs. 1459/10 6 lin - cells, p<0.0005). Likewise, a single dose (10mg/kg) of polyinosinic:polycytidylic acid (pI:pC) also significantly increased the number of LT-HSC (n=9; 460 vs. 2300/10 6 lin - cells, p<0.005) but not of MPP1 after 24h. In contrast, 5-Fluorouracil (5-FU; 150mg/kg) did not significantly change the number of LT-HSC and MPP1, 3- and 6-days post-injection. However, only mTPO and RP but not pI:pC or 5-FU significantly increased the fraction of Evi1 high expressing LT-HSC (23 vs. 50%, 23 vs. 49%; n=29, p<0.0001) and MPP1 (22 vs. 47%, 22 vs- 48%; n=29, p<0.0001). Transplantation of identical numbers of iMLL-AF9 LT-HSC and MPP1 isolated 2 days after mTPO application to the donors into irradiated syngeneic recipients resulted in a significantly faster induction of Evi1 + AML than controls (n=19, MPP1: 35 vs. 96.5d, p<0.0001; LT-HSC: 41 vs 146.5d, p<0.0001). Currently ongoing single-cell RNA sequencing experiments of LT-HSC and MPP1 with and without in vivo mTPO stimulation conditionally expressing the iMLL-AF9 fusion should provide some mechanistic insights into increased susceptibility for EVI1 + AML. Our results so far demonstrate that the dynamics of the HSC compartment critically affects the cellular origin and biology of MLL-AF9 driven AML. Disclosures Kurokawa: MSD K.K.: Research Funding, Speakers Bureau; Kyowa Hakko Kirin Co., Ltd.: Research Funding, Speakers Bureau; Eisai Co., Ltd.: Research Funding, Speakers Bureau; Otsuka Pharmaceutical Co., Ltd.: Research Funding, Speakers Bureau; ONO PHARMACEUTICAL CO., LTD.: Research Funding, Speakers Bureau; Takeda Pharmaceutical Company Limited.: Research Funding, Speakers Bureau; Chugai Pharmaceutical Company: Research Funding, Speakers Bureau; Astellas Pharma Inc.: Research Funding, Speakers Bureau; Pfizer Japan Inc.: Research Funding, Speakers Bureau; AbbVie GK: Research Funding, Speakers Bureau; Teijin Limited: Research Funding, Speakers Bureau; Daiichi Sankyo Company.: Research Funding, Speakers Bureau; Sumitomo Dainippon Pharma Co., Ltd.: Research Funding, Speakers Bureau; Nippon Shinyaku Co., Ltd.: Research Funding, Speakers Bureau.

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Cohen, R. B., I. M. Pereira, M. G. Marguilho, M. C. Sousa, and B. V. Ferreira. "Being mindful of our insomnia can get us to sleep? - Mindfulness aproach to sleep disorders." European Psychiatry 66, S1 (March 2023): S1104. http://dx.doi.org/10.1192/j.eurpsy.2023.2347.

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IntroductionSleep disorders (e.g., insomnia) are extremely prevalent in our population and are intimately associated with distress and productivity impairment. It is estimated that between 40 to 60% of people suffering from a sleep disorder have an underlying psychiatric diagnosis.Mindfulness, which is described as the quality or state of being self-conscious or aware of something, has shown to be a potential helpful therapy in insomnia.ObjectivesTherefore, and due to the lack of new and effective treatment approaches, we did a non-systematic review of the positive impact of mindfulness in quality of sleep.MethodsBibliographic research through PubMed, Web of Science and Springer Link.Results The mindfulness tools that may be linked to its therapeutic effects include the awareness state and conscious posture to respond when perceiving insomnia symptoms, as well as the modulation of sleep-related arousal courses. These can be primary when directly related to the inability to sleep, or secondary if considering the relationship with thoughts about sleep (such as the tendency to create bias in the attention and perception of sleep related thoughts). Formerly, mindfulness-based cognitive therapy (MTPC) was designed for the treatment of chronic depression and has shown to be efficacious. It was hypothesized that interoceptive dysfunction in the insula, commonly observed in anxiety and depression, may respond to MTPC by the gained interoceptive awareness, which provides advantage to adapt to life challenges and ongoing adjustments.ConclusionsBased on the currently available literature, mindfulness-based strategies may be a valuable treatment option in sleep disorders, especially for patients with concomitant mental illness. Therefore, it is necessary further research to standardize in terms of type of approach, duration, and outcome measures since it seems promising as an intervention for insomnia.Disclosure of InterestNone Declared

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Srinivasan, Ganesh, Abhijit Chatterjee, Sasikumar Cherubal, and Pramod Variyam. "Production Realization of MTPR Test on Low-Cost ATE for OFDM Based Communication Devices." Journal of Electronic Testing 26, no. 4 (August 2010): 405–17. http://dx.doi.org/10.1007/s10836-010-5161-z.

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Attanzio, Alessandro, Simone D’Agostino, Rosalia Busà, Anna Frazzitta, Simona Rubino, Maria Assunta Girasolo, Piera Sabatino, and Luisa Tesoriere. "Cytotoxic Activity of Organotin(IV) Derivatives with Triazolopyrimidine Containing Exocyclic Oxygen Atoms." Molecules 25, no. 4 (February 15, 2020): 859. http://dx.doi.org/10.3390/molecules25040859.

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In this study cytotoxicity of organotin(IV) compounds with 1,2,4-triazolo[1,5-a]pyrimidines, Me3Sn(5tpO) (1), n-Bu3Sn(5tpO) (2), Me3Sn(mtpO) (3), n-Bu3Sn(mtpO) (4), n-Bu3Sn(HtpO2) (5), Ph3Sn(HtpO2) (6) where 5HtpO = 4,5-dihydro-5-oxo-[1,2,4]triazolo-[1,5-a]pyrimidine, HmtpO = 4,7-dihydro-5-methyl-7-oxo-[1,2,4]triazolo-[1,5-a]pyrimidine, and H2tpO2 = 4,5,6,7-tetrahydro-5,7- dioxo-[1,2,4]triazolo-[1,5-a]-pyrimidine, was assessed on three different human tumor cell lines: HCT-116 (colorectal carcinoma), HepG2 (hepatocarcinoma) and MCF-7 (breast cancer). While 1 and 3 were inactive, compounds 2, 4, 5 and 6 inhibited the growth of the three tumor cell lines with IC50 values in the submicromolar range and showed high selectivity indexes towards the tumor cells (SI > 90). The mechanism of cell death triggered by the organotin(IV) derivatives, investigated on HCT-116 cells, was apoptotic, as evident from the externalization of phosphatidylserine to the cell surface, and occurred via the intrinsic pathway with fall of mitochondrial inner membrane potential and production of reactive oxygen species. While compound 6 arrested the cell progression in the G2/M cell cycle phase and increased p53 and p21 levels, compounds 2, 4 and 5 blocked cell duplication in the G1 phase without affecting the expression of either of the two tumor suppressor proteins. Compounds 1 and 2 were also investigated using single crystal X-ray diffraction and found to be, in both cases, coordination polymers forming 1 D chains based on metal-ligand interactions. Interestingly, for n-Bu3Sn(5tpO)(2) H-bonding interactions between 5tpO− ligands belonging to adjacent chains were also detected that resemble the “base-pairing” assembly and could be responsible for the higher biological activity compared to compound 1. In addition, they are the first example of bidentate N(3), O coordination for the 5HtpO ligand on two adjacent metal atoms.

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Xia, Bin, Yuxuan Bai, Junjie Yin, Qi Li, and Lijie Xu. "MTPR: A Multi-Task Learning Based POI Recommendation Considering Temporal Check-Ins and Geographical Locations." Applied Sciences 10, no. 19 (September 23, 2020): 6664. http://dx.doi.org/10.3390/app10196664.

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The rapid development of location-based social networks (LBSNs) produces the increasing number of check-in records and corresponding heterogeneous information which bring big challenges of points-of-interest (POIs) recommendation in our daily lives. The emergence of various recommender techniques bridges the gap between the numerous heterogeneous check-ins and the personalized POI recommendation. However, due to the differences between LBSNs and conventional recommendation tasks, besides the user feedback, the spatio-temporal information is also significant to precisely capture the user preferences. In this paper, we propose a multi-task learning model based POI recommender system which exploits a structure of generative adversarial networks (GAN) simultaneously considering temporal check-ins and geographical locations. The GAN-based model is capable of relieving the sparsity of check-in data in POI recommender systems. The temporal check-ins not only present the preference but also show the lifestyle of an individual while the geographical locations describe the active region of users which further filters POIs far from the feasible region. The multi-task learning strategy is capable of combining the information of temporal check-ins and geographical locations to improve the performance of personalized POI recommendation. We conduct the experiments on two real-world LBSNs datasets and the experimental results show the effectiveness of our proposed approach.

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Gao, Wei, Xiaotian Li, Da Ren, Susu Sun, Jingqian Huo, Yanen Wang, Lai Chen, and Jinlin Zhang. "Design and Synthesis of N-phenyl Phthalimides as Potent Protoporphyrinogen Oxidase Inhibitors." Molecules 24, no. 23 (November 29, 2019): 4363. http://dx.doi.org/10.3390/molecules24234363.

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Protoporphyrinogen oxidase (PPO) has been identified as one of the most promising targets for herbicide discovery. A series of novel phthalimide derivatives were designed by molecular docking studies targeting the crystal structure of mitochondrial PPO from tobacco (mtPPO, PDB: 1SEZ) by using Flumioxazin as a lead, after which the derivatives were synthesized and characterized, and their herbicidal activities were subsequently evaluated. The herbicidal bioassay results showed that compounds such as 3a (2-(4-bromo-2,6-difluorophenyl) isoindoline-1,3-dione), 3d (methyl 2-(4-chloro-1,3-dioxoisoindolin-2-yl)-5-fluorobenzoate), 3g (4-chloro-2-(5-methylisoxazol-3-yl) isoindoline-1,3-dione), 3j (4-chloro-2-(thiophen-2-ylmethyl) isoindoline-1,3-dione) and 3r (2-(4-bromo-2,6-difluorophenyl)-4-fluoroisoindoline-1,3-dione) had good herbicidal activities; among them, 3a showed excellent herbicidal efficacy against A. retroflexus and B. campestris via the small cup method and via pre-emergence and post-emergence spray treatments. The efficacy was comparable to that of the commercial herbicides Flumioxazin, Atrazine, and Chlortoluron. Further, the enzyme activity assay results suggest that the mode of action of compound 3a involves the inhibition of the PPO enzyme, and 3a showed better inhibitory activity against PPO than did Flumioxazin. These results indicate that our molecular design strategy contributes to the development of novel promising PPO inhibitors.

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Paudel, Jamuna Risal, and Jacqueline C. Bede. "Ethylene Signaling Modulates Herbivore-Induced Defense Responses in the Model Legume Medicago truncatula." Molecular Plant-Microbe Interactions® 28, no. 5 (May 2015): 569–79. http://dx.doi.org/10.1094/mpmi-10-14-0348-r.

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One or more effectors in the labial saliva (LS) of generalist Noctuid caterpillars activate plant signaling pathways to modulate jasmonate (JA)-dependent defense responses; however, the exact mechanisms involved have yet to be elucidated. A potential candidate in this phytohormone interplay is the ethylene (ET) signaling pathway. We compared the biochemical and molecular responses of the model legume Medicago truncatula and the ET-insensitive skl mutant to herbivory by fourth instar Spodoptera exigua (Hübner) caterpillars with intact or impaired LS secretions. Cellular oxidative stress increases rapidly after herbivory, as evidenced by changes in oxidized-to-reduced ascorbate (ASC) and glutathione (GSH) ratios. The caterpillar-specific increase in GSH ratios and the LS-specific increase in ASC ratios are alleviated in the skl mutant, indicating that ET signaling is required. Ten hours postherbivory, markers of the JA and JA/ET pathways are differentially expressed; MtVSP is induced and MtHEL is repressed in a caterpillar LS- and ET-independent manner. In contrast, expression of the classic marker of the systemic acquired resistance pathway, MtPR1, is caterpillar LS-dependent and requires ET signaling. Caterpillar LS further suppresses the induction of JA-related trypsin inhibitor activity in an ET-dependent manner. Findings suggest that ET is involved in the caterpillar LS-dependent, salicylic acid/NPR1-mediated attenuation of JA-dependent induced responses.

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Mirdad, Md Abdul Hamid, and Ying Hei Chui. "Stiffness prediction of Mass Timber Panel-Concrete (MTPC) composite connection with inclined screws and a gap." Engineering Structures 207 (March 2020): 110215. http://dx.doi.org/10.1016/j.engstruct.2020.110215.

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Xiong, Yige, Xiaohui Yan, Taibai Li, Huixin Jin, Ziliang Chen, Xuejiao Xu, Xiang Ji, and Xiang Ge. "Micro-tabless-pouch-cell (MTPC) with high energy density and exposed functional current collector for flexible device." Chemical Engineering Journal 451 (January 2023): 138913. http://dx.doi.org/10.1016/j.cej.2022.138913.

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REYNOLDS, D. SCOTT. "Monitoring the Potential Impact of A Wind Development Site on Bats in the Northeast." Journal of Wildlife Management 70, no. 5 (December 2006): 1219–27. http://dx.doi.org/10.2193/0022-541x(2006)70[1219:mtpioa]2.0.co;2.

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MACKENZIE, DARRYL I. "Modeling the Probability of Resource Use: The Effect of, and Dealing with, Detecting a Species Imperfectly." Journal of Wildlife Management 70, no. 2 (April 2006): 367–74. http://dx.doi.org/10.2193/0022-541x(2006)70[367:mtporu]2.0.co;2.

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Wielicki, Bruce A., Edwin F. Harrison, Robert D. Cess, Michael D. King, and David A. Randall. "Mission to Planet Earth: Role of Clouds and Radiation in Climate." Bulletin of the American Meteorological Society 76, no. 11 (November 1995): 2125–53. http://dx.doi.org/10.1175/1520-0477(1995)076<2125:mtpero>2.0.co;2.

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Kozub, Francis M., David L. Porretta, and Samuel R. Hodge. "Motor Task Persistence of Children With and Without Mental Retardation." Mental Retardation 38, no. 1 (February 2000): 42–49. http://dx.doi.org/10.1352/0047-6765(2000)038<0042:mtpocw>2.0.co;2.

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Yasuhara, Fujiko, Masayuki Takeda, Yoshiro Ochiai, Sotaro Miyano, and Shozo Yamaguchi. "α-Methoxy-α-trifluoromethylpropionic Acid (MTPr). A New Chiral Derivatizing Reagent for GC Separation of Enantiomeric Amino Acids." Chemistry Letters 21, no. 2 (February 1992): 251–52. http://dx.doi.org/10.1246/cl.1992.251.

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Mirdad, Md Abdul Hamid, and Ying Hei Chui. "Load-slip performance of Mass Timber Panel-Concrete (MTPC) composite connection with Self-tapping screws and insulation layer." Construction and Building Materials 213 (July 2019): 696–708. http://dx.doi.org/10.1016/j.conbuildmat.2019.04.117.

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Tsukahara, F., I. Urakawa, M. Hattori, M. Hirai, K. i. Ohba, T. Yoshioka, Y. Sakaki, and T. Muraki. "Molecular Characterization of the Mouse mtprd Gene, a Homologue of Human TPRD: Unique Gene Expression Suggesting Its Critical Role in the Pathophysiology of Down Syndrome." Journal of Biochemistry 123, no. 6 (June 1, 1998): 1055–63. http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022043.

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Hanji, Bhagyashri R., and Rajashree Shettar. "Cross Layer Solution for Energy and Delay Optimization in MANETs." International Journal of Electrical and Computer Engineering (IJECE) 8, no. 6 (December 1, 2018): 4745. http://dx.doi.org/10.11591/ijece.v8i6.pp4745-4754.

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A novel method for packet forwarding in MANETs has been proposed in this paper. A node in the network acts as both host and router. Energy utilization of the node increases as all nodes in MANET operate as source, destination, and router to forward packets to the next hop ultimately to reach destination. Routers execute a variety of functions from simple packet classification for forwarding to complex payload revision. As the number of tasks and complexity increases, processing time required also increases resulting in significant processing delay in routers. The proposed work optimizes packet header at transport and network layer by calculating Unique Identifier using pairing function for the fields which do not change for a source–destination pair. This technique optimizes the processing cost of each packet header thereby conserving energy and reducing delay. It also simplifies the task of system administration. This paper elucidates an extension to basic AODV protocol, allowing routing of most packets without an explicit header, reducing the overhead of the protocol while still conserving its basic properties. The proposed method improves the network performance significantly compared to AODV, MTPR, and S-AODV protocol.

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YASUHARA, F., M. TAKEDA, Y. OCHIAI, S. MIYANO, and S. YAMAGUCHI. "ChemInform Abstract: α-Methoxy-α-trifluoromethylpropionic Acid (MTPr). A New Chiral Derivatizing Reagent for GC Separation of Enantiomeric Amino Acids." ChemInform 23, no. 49 (September 1, 2010): no. http://dx.doi.org/10.1002/chin.199249060.

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Glac, Antonín, Václav Šmídl, Zdeněk Peroutka, and Christoph M. Hackl. "Dependence of IPMSM Motor Efficiency on Parameter Estimates." Sustainability 13, no. 16 (August 19, 2021): 9299. http://dx.doi.org/10.3390/su13169299.

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The efficiency of an IPMSM motor is influenced by the operating point of the machine. Conventional approaches to generate measured efficiency maps may be too expensive to use in some situations, thus it often replaced by simpler variants based on parametric models. A promising approach is to combine model-based approaches with online parameter identification methods which would allow following changes of the parameters. However, such approaches may also result in deteriorated performance if the online parameter estimation is inaccurate. We present a systematic experimental study of the influence of the parameter estimates on the efficiency of a 4.5 kW IPMSM drive and analyze the sources of inaccuracy. The first outcome of this study is that none of the tested methods performs well when the machine is fully loaded, which deteriorates overall performance. The second outcome is that the conventional maximum torque per ampere/current (MTPA/MTPC) is not an accurate optimization criterion. The overall performance of the compared methods thus heavily depends on the testing profile. When a significant part of the profile is at full load, the methods based on online estimation are unsuitable and parameters estimated offline using frequency domain provides better efficiency under the maximum torque per current control strategy.

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Journal articles on the topic 'MtProC'

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