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Books on the topic 'MTOR'

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Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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1

Weichhart, Thomas, ed. mTOR. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-430-8.

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2

Polunovsky, Vitaly A., and Peter J. Houghton, eds. mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60327-271-1.

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3

Houghton, Peter J., and V. A. Polunovskiĭ. mTOR pathway and mTOR inhibitors in cancer therapy. New York: Humana Press, 2010.

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4

mTor: Methods and protocols. New York: Humana Press, 2012.

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5

Dey, Nandini, Pradip De, and Brian Leyland-Jones, eds. PI3K-mTOR in Cancer and Cancer Therapy. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-34211-5.

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6

Mita, Monica, Alain Mita, and Eric K. Rowinsky, eds. mTOR Inhibition for Cancer Therapy: Past, Present and Future. Paris: Springer Paris, 2016. http://dx.doi.org/10.1007/978-2-8178-0492-7.

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7

"Khorhē ew mtir--": "Tsanir zkʻez--". [S.l.]: Hratarakutʻiwn Hayk ew Ēlza Titizean Fonti, 2011.

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8

Transportation, Ontario Ministry of. MTO drainage management manual. [Toronto]: Ministry of Transportation, 1995.

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9

The official MTO driver's handbook. Ontario]: Road User Safety Division of the Ministry of Transportation of Ontario, 2013.

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10

Associates, R. V. Anderson, and Ontario Ministry of Transportation, eds. MTO drainage management technical guidelines. Downsview, Ont: Highway Design Office, Highway Engineering Division, Ontario Ministry of Transportation, 1989.

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11

Ontario. Ministry of Transportation. Road User Safety Division. The official MTO motorcycle handbook. [Downsview, Ont.]: Road User Safety Division, Ministry of Transportation of Ontario, 2012.

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12

Ontario. Ministry of Transportation. Road User Safety Division, ed. The Official MTO Driver's Handbook. [Toronto]: Road User Safety Division, Ministry of Transportation, 2015.

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13

Karekin. "Khorhē ew mtir--": Khoher ew hayeatsʻkʻner dprevankʻi masin. S. Ējmiatsin: [s.n.], 1995.

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14

Vegesack, Thomas von. Iakttagelser vid grnsen: Nr sknlitteraturen mter sina vedersakare. Stockholm: Natur och Kultur, 2002.

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15

ller-Philipp, Susanne Mu. Leitfaden Geometrie: Fu r Studierende der Lehra mter. 5th ed. Wiesbaden: Vieweg + Teubner, 2012.

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16

Mayya, Sadānanda. Savijīvana: Eṃ. Ṭi. Ār. Sadānanda Mayyara sādhanākathana. Hubbaḷḷi: Sāhitya Prakāśana, 2009.

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17

Mayya, Sadānanda. Savijīvana: Eṃ. Ṭi. Ār. Sadānanda Mayyara sādhanākathana. Hubbaḷḷi: Sāhitya Prakāśana, 2009.

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18

Mayya, Pi Sadānanda. Savijīvana: Eṃ. Ṭi. Ār. Sadānanda Mayyara sādhanākathana. Hubbaḷḷi: Sāhitya Prakāśana, 2009.

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19

B-25J "Mitchell" in combat over Europe (MTO). Lublin, Poland: Kagero, 2013.

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20

Ontario. Ministry of Transportation. Licensing and Control Branch. The official MTO motorcycle handbook: Get the latest updates! [Downsview]: Road User Safety Division, Ministry of Transportation of Ontario, 2007.

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21

Chattle, M. V. Intercomparison of gallium sealed cells: BCR project MTR-38. Luxembourg: Commissionof the European Communities, 1985.

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22

Molesworth, Carl. P-40 warhawk vs Bf 109: Mto 1942-44. Oxford, UK: Osprey, Publishing, 2011.

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23

Ontario. Ministry of Transportation. Road User Safety Division. The official MTO bus handbook: Get the latest updates! [Downsview]: Road User Safety Divison, Ministry of Transportation of Ontario, 2007.

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24

Lumis, G. P. An evaluation of MTO specifications for tree planting and maintenance. Downsview, Ont: Research and Development Branch, Ontario Ministry of Transportation, 1990.

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25

Ontario. Ministry of Transportation. Licensing and Control Branch. The official MTO air brake handbook: Get the latest updates! [Downsview]: Road User Safety Division, Ministry of Transportation of Ontario, 2007.

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26

Wimmelbücker, Ludger. Mtoro bin Mwinyi Bakari (c. 1869-1927): Swahili lecturer and author in Germany. Dar es Salaam: Mkuki na Nyota, 2009.

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27

Mtoro bin Mwinyi Bakari (c. 1869-1927): Swahili lecturer and author in Germany. Dar es Salaam: Mkuki na Nyota, 2009.

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28

Houghton, Peter J., and Vitaly A. Polunovsky. mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Humana, 2012.

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29

Pelton, Ross. Rapamycin: Rapamycin, MTOR, Autophagy and Treating MTOR Syndrome. Praktikos Books, 2022.

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30

mTOR in Human Diseases. MDPI, 2019. http://dx.doi.org/10.3390/books978-3-03921-061-9.

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31

Weichhart, Thomas. mTOR: Methods and Protocols. Humana Press, 2016.

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32

Choo, Andrew Yoon. mTOR, metabolism, and cancer. 2009.

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33

Molecules to Medicine with mTOR. Elsevier, 2016. http://dx.doi.org/10.1016/c2014-0-03321-7.

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34

Pelton, Ross. Rapamycin, MTOR, Autophagy and Treating MTOR Syndrome: Rapamycin the Most Promising Life Extension Drug. Praktikos Books, 2022.

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35

Pelton, Ross. Rapamycin, MTOR, Autophagy, & Treating MTOR Syndrome : Rapamycin: The World's Most Promising Life Extension Drug. FreshLife Media, 2022.

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36

mTOR Signaling in Metabolism and Cancer. MDPI, 2020. http://dx.doi.org/10.3390/books978-3-03943-554-8.

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37

Arcaro, Alexandre, ed. Targeting PI3K/mTOR signaling in cancer. Frontiers Media SA, 2014. http://dx.doi.org/10.3389/978-2-88919-244-1.

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38

Leyland-Jones, Brian, Nandini Dey, and Pradip De. PI3K-mTOR in Cancer and Cancer Therapy. Humana, 2016.

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39

Leyland-Jones, Brian, Nandini Dey, and Pradip De. PI3K-mTOR in Cancer and Cancer Therapy. Humana, 2018.

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40

Leyland-Jones, Brian, Nandini Dey, and Pradip De. PI3K-MTOR in Cancer and Cancer Therapy. Humana Press, 2016.

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41

Regulatory mechanisms in the Akt-mTOR signalings axis. 2009.

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42

Mita, Monica, Alain Mita, and Eric K. Rowinsky. MTOR Inhibition for Cancer Therapy: Past, Present and Future. Springer London, Limited, 2015.

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43

Mita, Monica, Alain Mita, and Eric K. Rowinsky. mTOR Inhibition for Cancer Therapy: Past, Present and Future. Springer, 2016.

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44

Kramer, Carolyn, and Emily Blumberg. Immunosuppressants and Antiretroviral Therapy in HIV-Positive Transplant Patients. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0028.

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Abstract:

Protease inhibitors (PIs), especially ritonavir, are inhibitors of CYP3A4 and P-gp1 and can significantly increase levels of calcineurin inhibitors and mammalian target of rapamycin (mTOR) inhibitors. Cobicistat is an inhibitor of CYP3A4, and its effect on levels of calcineurin inhibitors and mTOR inhibitors is likely to be similar to that of ritonavir. Efavirenz may result in lower concentrations of calcineurin inhibitors and mTOR inhibitors. Dose reduction and careful attention to monitoring drug levels are critical to avoid toxicity and maintain therapeutic immunosuppressive concentrations when PIs or cobicistat are coadministered with calcineurin inhibitors or mTOR inhibitors. Although there is no formalized recommendation for the ideal antiretroviral therapy regimen in HIV-positive transplant recipients, a regimen consisting of two nucleoside reverse transcriptase and an integrase inhibitor minimizes the risk of drug–drug interactions and simplifies dosing of immunosuppressive agents while maintaining a high barrier to resistance.

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45

Krueger, Darcy A., and Jamie Capal. Familial CNS Tumor Syndromes. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0136.

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Tuberous sclerosis complex is an autosomal dominant multi-system disease that involves the skin, brain, heart, lungs, and kidneys and is associated with seizures including infantile spasms, intellectual disability, autism and pulmonary and heart disease. Skin lesions can be particularly disfiguring and infantile spasms can be associated with marked cognitive decline. The outlook for patients has improved markedly with the recognition that TSC is caused by upregulation of the mammalian target of rapamycin (mTOR) enzyme, which connects energy needs and supply with cellular and neuronal growth. mTOR is upregulated in TSC because of mutations in hamartin or tuberin, which normally serve as a brake on mTOR. The drug rapamycin is commonly used as an immunosuppressive for patients undergoing kidney transplants; it has also found a new use in patients with TSC. Although the drug is immunosuppressive for non-TSC patients, careful titration of the drug in TSC patients corrects its upregulation but is not particulary immunosuppressive. Additional mTOR inhibitors such as everolimus have been developed and have been shown to be effective for pulmonary disease associated with TSC. Rapamycin in ointment form is dramatically effective in suppressing skin lesions of TSC and studies are underway to test the effect of mTOR inhibitors on seizures, brain tubers, intellect, and features of autism. Infantile spasms associated with TSC are very responsive to vigabatrin.

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46

Maiese, Kenneth. Molecules to Medicine with MTOR: Translating Critical Pathways into Novel Therapeutic Strategies. Elsevier Science & Technology Books, 2016.

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47

Birle, Diana C. Interactions between inhibitors of mTOR and EGFR/ERK signaling in SiHa cervical carcinoma. 2004.

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48

Weiner, Howard, and Peter B. Crino. Familial tumour syndromes: tuberous sclerosis complex. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199651870.003.0017.

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Tuberous sclerosis complex (TSC) is a multisystem, genetic disorder that results from mutations in TSC1 or TSC2 genes. Neurological and neuropsychiatric disabilities include epilepsy, intellectual disability, autism, attention deficit disorder, and generalized anxiety. Cortical dysplasias (also known as tubers) are developmental abnormalities of the cerebral cortex that are believed to be responsible for seizures, cognitive disability, and autism. Subependymal giant cell astrocytomas (SEGAs) are intraventricular tumours that can cause hydrocephalus, increased intracranial pressure, and death. TSC results from hyperactivation of the mammalian target of rapamycin (mTOR) pathway in neurons in the brain. This chapter reviews the clinical presentations of TSC as well as diagnostic approaches for epilepsy and SEGAs. It discusses the genetics and cellular pathogenesis of TSC as well as reviewing the link to mTOR signalling. This chapter also presents evidence for different treatment modalities for seizures and SEGAs. It is written for qualified specialist physicians and caregivers.

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49

Land, Siim. Metabolic Autophagy Cookbook: Eat Foods That Boost Autophagy, Balance MTOR for Longevity, and Build Muscle. Independently Published, 2019.

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50

Maiese, Kenneth. Molecules to Medicine with MTOR: Translating Critical Pathways of the Mammalian Target of Rapamycin into Novel Therapeutic Strategies. Elsevier Science & Technology Books, 2016.

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