Relevant bibliographies by topics / MSU-H

Academic literature on the topic 'MSU-H'

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Published: 14 March 2023

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Journal articles on the topic "MSU-H"

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Huang, Y., Y. Liu, Q. Huang, W. Deng, and T. W. Li. "POS0133 MONOSODIUM URATE CRYSTALS REDUCE HUMAN LIGAMENT CELLS VIABILITY THROUGH INCREASE OF ROS PRODUCTION." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 278.1–278. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2316.

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Background:Ligament destruction is a frequent complication of gout and is strongly associated with tophi. Ligament fibroblasts are important cellular mediators of ligament remodeling. None of study has paid attention to the effects of monosodium urate (MSU) crystals on ligament fibroblasts.Objectives:The study aims to investigate the effects and mechanism of MSU crystals on ligament fibroblasts.Methods:MSU crystals were added to human ligament fibroblasts(HLFs) cultures or primary ligament cells cultures. Cell counting kit-8 (CCK-8) assay, cell migration assay, Annexin V-FITC/PI assay were conducted. Reactive Oxygen Species(ROS) was tested by ROS Assay Kit.Results:The higher concentrations of MSU crystals (0.5-1mg/mL) reduced the viability of HLFs or primary ligament cells after 24 h as assessed by CCK8 assays, with a further reduction in viability observed at the 48 h time point. When observed under light microscopy, HLFs cultured with MSU crystals (0.5mg/mL) appeared unhealthy with fewer cells present. The cell migration ability of HLFs was decreased significantly on MSU crystals (0.5mg/mL). According to the result of Annexin V-FITC/PI assay, the survival rate of HLFs on MSU crystals (0.5mg/mL) was lower than that of 0.25mg/ml and 0 mg/ml at 72h. ROS assay results showed that the production of ROS increased as the concentrations of MSU crystals increased.Conclusion:MSU crystals inhibit human ligament cells viability through the increase of ROS production. It may contribute to disordered ligament remodeling in gout patients with ligament destruction.References:[1]Ashika Chhana, et al. Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state. Arthritis Res Ther. 2018, 20(1): 208.Figure 1.MSU crystals reduce human ligament fibroblasts and primary human ligament cells viability over time. A: CCK-8 assay; B: Observation of HLFs morphology; C: Annexin V-FITC/PI assay.Disclosure of Interests:None declared
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Jiang, Hui, Feng Chen, DianZe Song, Xiaoqin Zhou, Long Ren, and Mei Zeng. "Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals." Oxidative Medicine and Cellular Longevity 2022 (October 25, 2022): 1–22. http://dx.doi.org/10.1155/2022/5064494.

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Excessive generation of reactive oxygen species (ROS) has great impacts on MSU crystal-induced inflammation. Drp1-dependent mitochondrial fission is closely associated with mitochondrial ROS levels. However, whether Drp1 signaling contributes to MSU crystal-induced inflammation remains unclear. Mice bone marrow-derived macrophages (BMDMs) were primed with LPS and then stimulated with MSU suspensions for 12 h. The protein levels associated with mitochondrial dynamics, oxidative stress, and mitophagy were detected by Western blot. BMDMs were loaded with MitoTracker Green probe to detect mitochondrial morphology. To measure mitochondrial reactive oxygen species (ROS) and total ROS levels, cells were loaded, respectively, with MitoSOX and DHE probes. The effects of Mito-TEMPO, an antioxidant that targets the mitochondria or DRP1 inhibitor (Mdivi-1) on MSU crystal-induced peritonitis and arthritis mouse models, were evaluated. Our study revealed that MSU crystal stimulation resulted in elevation of mitochondrial fragmentation of BMDMs. Treatment with Mito-TEMPO or Drp1 knockdown significantly ameliorated the mitochondrial damage induced by MSU crystals. BMDMs exposure to MSU crystals increased the expression of auto/mitophagy marker proteins and promoted the fusion of mitophagosomes with lysosomes, leading to accumulation of mitolysosomes. Drp1 knockdown alleviated defective mitophagy and activation of the NLRP3 inflammasome in MSU crystal-treated BMDMs. This study indicates that there is crosstalk between mitochondrial ROS and Drp1 signaling in MSU crystal-induced inflammation. Drp1 signaling is involved in MSU crystal-induced mitochondrial damage, impaired mitophagy and NLRP3 inflammasome activation.
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Abe, Hiroyuki, Robert Anthony Antonia, and Sadayoshi Toh. "Large-scale structures in a turbulent channel flow with a minimal streamwise flow unit." Journal of Fluid Mechanics 850 (July 6, 2018): 733–68. http://dx.doi.org/10.1017/jfm.2018.434.

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Direct numerical simulations are used to examine large-scale motions with a streamwise length$2\sim 4h$($h$denotes the channel half-width) in the logarithmic and outer regions of a turbulent channel flow. We test a minimal ‘streamwise’ flow unit (Toh & Itano,J. Fluid Mech., vol. 524, 2005, pp. 249–262) (or MSU) for larger Kármán numbers ($h^{+}=395$and 1020) than in the original work. This flow unit consists of a sufficiently long (${L_{x}}^{+}\approx 400$) streamwise domain to maintain near-wall turbulence (Jiménez & Moin,J. Fluid Mech., vol. 225, 1991, pp. 213–240) and a spanwise domain which is large enough to represent the spanwise behaviour of inner and outer structures correctly; as$h^{+}$increases, the streamwise extent of the MSU domain decreases with respect to$h$. Particular attention is given to whether the spanwise organization of the large-scale structures may be represented properly in this simplified system at sufficiently large$h^{+}$and how these structures are associated with the mean streamwise velocity$\overline{U}$. It is shown that, in the MSU, the large-scale structures become approximately two-dimensional at$h^{+}=1020$. In this case, the streamwise velocity fluctuation$u$is energized, whereas the spanwise velocity fluctuation$w$is weakened significantly. Indeed, there is a reduced energy redistribution arising from the impaired global nature of the pressure, which is linked to the reduced linear–nonlinear interaction in the Poisson equation (i.e. the rapid pressure). The logarithmic dependence of$\overline{ww}$is also more evident due to the reduced large-scale spanwise meandering. On the other hand, the spanwise organization of the large-scale$u$structures is essentially identical for the MSU and large streamwise domain (LSD). One discernible difference, relative to the LSD, is that the large-scale structures in the MSU are more energized in the outer region due to a reduced turbulent diffusion. In this region, there is a tight coupling between neighbouring structures, which yields antisymmetric pairs (with respect to centreline) of large-scale structures with a spanwise spacing of approximately$3h$; this is intrinsically identical with the outer energetic mode in the optimal transient growth of perturbations (del Álamo & Jiménez,J. Fluid Mech., vol. 561, 2006, pp. 329–358).
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Goo, Bonhyuk, Jeeyoun Lee, Chansol Park, Taeyoung Yune, and Yeoncheol Park. "Bee Venom Alleviated Edema and Pain in Monosodium Urate Crystals-Induced Gouty Arthritis in Rat by Inhibiting Inflammation." Toxins 13, no. 9 (September 16, 2021): 661. http://dx.doi.org/10.3390/toxins13090661.

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Bee venom (BV) acupuncture has anti-inflammatory and analgesic effects; therefore, it was used as a traditional Korean medicine for various musculoskeletal disorders, especially arthritis. In this study, we investigated the effect of BV on monosodium urate (MSU) crystal-induced acute gouty rats. An intra-articular injection of MSU crystal suspension (1.25 mg/site) was administered to the tibiotarsal joint of the hind paw of Sprague Dawley rats to induce MSU crystal-induced gouty arthritis. Colchicine (30 mg/kg) was orally administered 1 h before MSU crystal injection as a positive control, and BV (0.5 mg/kg) was injected into the tibiotarsal joint immediately after MSU crystal injection. The ankle thickness, mechanical allodynia, and expression of proinflammatory cytokines (TNF-α, IL-1β, IL6, COX2 and iNOS) and chemokines (MIP-1α, MIP-1β, MCP-1, GRO-α, MIP-2α) were then evaluated. BV reduced the expression of proinflammatory cytokines and chemokines, which are important mediators of MSU crystal-induced inflammatory responses. This anti-inflammatory effect was also confirmed histologically to attenuate synovitis and neutrophil infiltration. We demonstrated that BV markedly ameliorated ankle edema and mechanical allodynia in gouty rats. These results suggest that BV acupuncture is a potential clinical therapy for acute gouty management.
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Cherian, Mathew, Pankaj Mehta, Shriram Varadharajan, Santosh Poyyamozhi, Elango Swamiappan, Jenny Gandhi, and Nithin Theckumparampil. "Retrospective Review and Proof of Concept of Asia’s First Mobile Stroke Unit Experience in Kovai Medical Center and Hospital." Journal of Stroke Medicine 3, no. 2 (December 2020): 116–23. http://dx.doi.org/10.1177/2516608520968418.

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Background: We review our initial experience of India’s and Asia’s first mobile stroke unit (MSU) following the completion of its first year of operation. We outline the clinical care pathway integrating the MSU services using a case example taking readers along our clinical care workflow while highlighting the challenges faced in organizing and optimizing such services in India. Methods: Retrospective review of data collected for all patients from March 2018 to February 2019 transported and treated within the MSU during the first year of its operation. Recent case example is reviewed highlighting complete comprehensive acute clinical care pathway from prehospital MSU services to advanced endovascular treatment with focus on challenges faced in developing nation for stroke care. Results: The MSU was dispatched and utilized for 14 patients with clinical symptoms of acute stroke. These patients were predominantly males (64%) with median age of 59 years. Ischemic stroke was seen in 7 patients, hemorrhagic in 6, and 1 patient was classified as stroke mimic. Intravenous tissue plasminogen activator was administered to 3 patients within MSU. Most of the patients’ treatment was initiated within 2 h of symptom onset and with the median time of patient contact (rendezvous) following stroke being 55 mins. Conclusion: Retrospective review of Asia’s first MSU reveals its proof of concept in India. Although the number of patients availing treatment in MSU is low as compared to elsewhere in the world, increased public awareness with active government support including subsidizing treatment costs could accelerate development of optimal prehospital acute stroke care policy in India.
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Pascart, T., P. Carpentier, L. Norberciak, J. Legrand, E. Houvenagel, F. Becce, and J. F. Budzik. "OP0175 IDENTIFYING PERIPHERAL VASCULAR MONOSODIUM URATE CRYSTAL DEPOSITION WITH DUAL-ENERGY CT: FACT OR FICTION? THE VASCURATE STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 109.2–109. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4522.

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Background:The close relationship between gout and cardiovascular diseases is well established. A growing hypothesis explaining this association would be that monosodium urate (MSU) crystals are deposited within vessel walls. Dual-energy computed tomography (DECT) can identify and quantify MSU crystal deposition in soft tissues. It remains unclear whether vascular spots exhibiting DECT attenuation characteristics of MSU are artefacts or true MSU crystal deposits.Objectives:The objectives of this study were to determine whether the presence of peripheral vascular MSU crystal deposition identified with DECT is associated with the extent of MSU deposits in joint soft tissues, and if this association persists over time under urate-lowering therapy.Methods:Patients with a clinical suspicion or established gout diagnosis prospectively underwent DECT for identification and quantification of the MSU crystal burden in their knees and feet. Some of these patients were also enrolled in the GOUT-DECTUS longitudinal study, and thus underwent follow-up DECT scans of their knees and feet at 6, 12 and 24 months. DECT scans were examined for the presence of vascular spots ≥0.01 cm3 classified as MSU crystal deposits according to the default post-processing settings. Multiple linear regressions adjusting on serum urate levels and gout diagnosis were implemented to determine the association between DECT MSU crystal volume in joint soft tissues, and the presence of vascular MSU deposits. Mixed linear models were used to compare DECT volumes of MSU crystal deposition in soft tissues between vascular MSU positive and negative patients during follow-up.Results:A total of 169 patients were included, of which 140 had a final diagnosis of gout, including 15 also included in the longitudinal study. Patients were mostly male (78.8%) and were 65.5 ± 14.6 years old. Among gout patients, disease duration was 9.3 ± 9.9 years and 56.5% were urate lowering therapy-naive. A total of 11/29 (37.9%) controls and 40/140 (28.6%) gout patients presented with a least one vascular spot of DECT MSU deposition, with an average volume of 0.02 ± 0.02 cm3, and all subjects also presented at least one vascular calcification. In the feet, patients positive for vascular DECT MSU crystal deposition had an MSU volume of 3.81 ± 10.06 cm3 in joint soft tissues, compared with 1.85 ± 7.72 cm3 for those without vascular MSU deposition (p=0.018). In the knees, patients with vascular MSU deposition had an MSU crystal volume of 6.03 ± 24.13 cm3 in joint soft tissues, compared with 0.83 ± 2.88 cm3 for those without vascular evidence of MSU deposition. In the longitudinal subgroup analysis, coefficients of the fixed effects for the presence of vascular MSU deposits on the MSU crystal volume in joint soft tissues was 0.4 (p=0.35) in the feet and 1.21 (p=0.03) in the knees. The presence of vascular DECT MSU deposits was associated with a 3.4-fold increase in MSU crystal volume in knee joint soft tissues throughout follow-up.Conclusion:This study suggests that some vascular spots identified with DECT as MSU crystal deposition may be real and not artefacts. This correlation remains throughout follow-up in the knees. However, the comparable prevalence of vascular DECT MSU deposits between gout patients and controls, the systematic co-existence of vascular calcifications and the uneven regression under urate-lowering therapy requires further analysis to determine which DECT spots are artefacts and which are not.References:[1]Dual-Energy Computed Tomography Detection of Cardiovascular Monosodium Urate Deposits in Patients With Gout. Klauser AS, Halpern EJ, Strobl S, Gruber J, Feuchtner G, Bellmann-Weiler R, Weiss G, Stofferin H, Jaschke W.Disclosure of Interests:Tristan Pascart Grant/research support from: Research Grant Horizon Pharma, Consultant of: Novartis, BMS, Sanofi, Pfizer,, Speakers bureau: Novartis, BMS, Paul Carpentier: None declared, Laurène Norberciak: None declared, Julie Legrand: None declared, Eric Houvenagel Speakers bureau: Janssen, Novartis, Fabio Becce: None declared, Jean-François Budzik: None declared
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Powers, Nicholas E., Benjamin Swartzwelter, Carlo Marchetti, Dennis M. de Graaf, Alexandra Lerchner, Martin Schlapschy, Rajiv Datar, et al. "PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis." Journal of Biological Chemistry 295, no. 3 (December 9, 2019): 868–82. http://dx.doi.org/10.1074/jbc.ra119.010340.

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Interleukin-1 (IL-1) is a key mediator of inflammation and immunity. Naturally-occurring IL-1 receptor antagonist (IL-1Ra) binds and blocks the IL-1 receptor-1 (IL-1R1), preventing signaling. Anakinra, a recombinant form of IL-1Ra, is used to treat a spectrum of inflammatory diseases. However, anakinra is rapidly cleared from the body and requires daily administration. To create a longer-lasting alternative, PASylated IL-1Ra (PAS–IL-1Ra) has been generated by in-frame fusion of a long, defined-length, N-terminal Pro/Ala/Ser (PAS) random-coil polypeptide with IL-1Ra. Here, we compared the efficacy of two PAS–IL-1Ra molecules, PAS600–IL-1Ra and PAS800–IL-1Ra (carrying 600 and 800 PAS residues, respectively), with that of anakinra in mice. PAS600–IL-1Ra displayed markedly extended blood plasma levels 3 days post-administration, whereas anakinra was undetectable after 24 h. We also studied PAS600–IL-1Ra and PAS800–IL-1Ra for efficacy in monosodium urate (MSU) crystal-induced peritonitis. 5 days post-administration, PAS800–IL-1Ra significantly reduced leukocyte influx and inflammatory markers in MSU-induced peritonitis, whereas equimolar anakinra administered 24 h before MSU challenge was ineffective. The 6-h pretreatment with equimolar anakinra or PAS800–IL-1Ra before MSU challenge similarly reduced inflammatory markers. In cultured A549 lung carcinoma cells, anakinra, PAS600–IL-1Ra, and PAS800-IL-Ra reduced IL-1α–induced IL-6 and IL-8 levels with comparable potency. In human peripheral blood mononuclear cells, these molecules suppressed Candida albicans–induced production of the cancer-promoting cytokine IL-22. Surface plasmon resonance analyses revealed significant binding between PAS–IL-1Ra and IL-1R1, although with a slightly lower affinity than anakinra. These results validate PAS–IL-1Ra as an active IL-1 antagonist with marked in vivo potency and a significantly extended half-life compared with anakinra.
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Alessi, A., G. Buscarino, S. Agnello, F. Messina, L. Sciortino, M. Cannas, and F. M. Gelardi. "Effects of Pressure, Thermal Treatment, and O2 Loading in MCM41, MSU-H, and MSU-F Mesoporous Silica Systems Probed by Raman Spectroscopy." Journal of Physical Chemistry C 119, no. 49 (December 2, 2015): 27434–41. http://dx.doi.org/10.1021/acs.jpcc.5b10206.

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Kwok, Jun Sheng, Kate Fox, Cees Bil, Francesca Langenberg, Anna H. Balabanski, Angela Dos Santos, Andrew Bivard, et al. "Bringing CT Scanners to the Skies: Design of a CT Scanner for an Air Mobile Stroke Unit." Applied Sciences 12, no. 3 (January 31, 2022): 1560. http://dx.doi.org/10.3390/app12031560.

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Stroke is the second most common cause of death and remains a persistent health challenge globally. Due to its highly time-sensitive nature, earlier stroke treatments should be enforced for improved patient outcome. The mobile stroke unit (MSU) was conceptualized and implemented to deliver the diagnosis and treatment to a stroke patient in the ultra-early time window (<1 h) in the pre-hospital setting and has shown to be clinically effective. However, due to geographical challenges, most rural communities are still unable to receive timely stroke intervention, as access to specialized stroke facilities for optimal stroke treatment poses a challenge. Therefore, the aircraft counterpart (Air-MSU) of the conventional road MSU offers a plausible solution to this shortcoming by expanding the catchment area for regional locations in Australia. The implementation of Air-MSU is currently hindered by several technical limitations, where current commercially available CT scanners are still oversized and too heavy to be integrated into a conventional helicopter emergency medical service (HEMS). In collaboration with the Australian Stroke Alliance and Melbourne Brain Centre, this article aims to explore the possibilities and methodologies in reducing the weight and, effectively, the size of an existing CT scanner, such that it can be retrofitted into the proposed search and rescue helicopter—Agusta Westland AW189. The result will be Australia’s first-ever customized CT scanner structure designed to fit in a search-and-rescue helicopter used for Air-MSU.
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He, Menglin, Cheng Hu, Meijuan Chen, Qian Gao, Liqiu Li, and Weiqian Tian. "Effects of Gentiopicroside on activation of NLRP3 inflammasome in acute gouty arthritis mice induced by MSU." Journal of Natural Medicines 76, no. 1 (September 29, 2021): 178–87. http://dx.doi.org/10.1007/s11418-021-01571-5.

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AbstractAcute gouty arthritis is a self-limiting inflammatory disease resulting from the deposition of monosodium urate (MSU) crystals. It has been shown that Gentiopicroside (GPS) possesses anti-inflammatory and analgesic functions. The aim of this study was to parse out whether GPS has an effect on acute gouty arthritis. We established an acute gouty arthritis model by the injection of MSU into the paw, and found that GPS relieves MSU-induced mechanical, thermal hyperalgesia, and paw swelling. Furthermore, GPS down-regulated the release of pro-inflammatory cytokines in paw tissues, including IL-1β, IL-6, IL-18, and TNF-α. The results of H&E staining and MPO activity measurement showed that GPS inhibits neutrophil infiltration. And the over-expressions of NOD-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and Caspase-1 induced by MSU were inhibited by treatment with GPS. These results revealed that GPS can treat acute gouty arthritis based on anti-inflammatory and analgesic properties in vivo, which might be ascribed to the inhibition on NLRP3 inflammasome. Furthermore, we performed in vitro study to confirm the results of in vivo study. Consistently, the results proved that GPS could inhibit the activation of NLRP3 inflammasome in RAW264.7 macrophages stimulated by LPS-MSU. In conclusion, this study provides an experimental basis for the application of GPS and expands the potential value of GPS in the therapy of acute gouty arthritis.
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Dissertations / Theses on the topic "MSU-H"

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Rehan, Naveed. "Rationalism and D. H. Lawrence : a 21st century perspective." Thesis, Montana State University, 2004. http://etd.lib.montana.edu/etd/2004/rehan/RehanN04.pdf.

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Since the time of the Greek philosopher Plato, Western intellectuals have relied on logos or \"the word\" to make philosophical propositions about the world humans find themselves in. Logos or \"the word\" has generally been privileged over mythos or pathos, denoting emotion and feeling. This privileging has sometimes been challenged by intellectuals within the Western tradition. D. H. Lawrence was the most vocal and passionate writer to do so in modern times. This text traces the development of rationalism in the Western tradition and Lawrence\'s resistance to it. It also examines modern theoretical developments and notes their convergence with Lawrence\'s ideas. It concludes by claiming that the postmodern intellectual climate in the West tends towards a critique of rationalism, much like Lawrence.
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GIGNONE, ANDREA. "Ordered Mesoporous Silica for Drug Delivery in Topical Applications." Doctoral thesis, Politecnico di Torino, 2016. http://hdl.handle.net/11583/2652565.

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The aim of this PhD work was to develop and characterize all physicochemical aspects of this new CRT for CTZ and AKS using OMS until the introduction onto the market. The first part comprehends the characterization of different OMS synthesized and commercially available; the study of different incorporation techniques based on hydrophilicity/hydrophobicity of API; the characterization of the new impregnated OMS. Consequently, the work is oriented on the interaction details of API on silica surfaces. A closer look is given to the big questions of OMS-drug phenomena: mobility, solubility, bioavailability, etc. Therefore, all the scCO2 incorporation parameters have been studied, highlighting the differences between OMS and the spatial assembly of drug inside the mesoporous channels. Thus, the patented CRT has been developed for AKS describing all the main aspect of the innovative semisolid formulation. In-vitro and ex-vivo release test has been produced and characterized, revealing the functionality of the OMS reservoir effect. Finally, the same DDS have been developed for CTZ. Both the DDS have been compared with commercially available creams.
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Botha, Johanna Margaretha. "The stabilising effect of met[h]ylsulfonylmethane (MSM) on urea containing formulations / Johanna Margaretha Botha." Thesis, North-West University, 2004. http://hdl.handle.net/10394/617.

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The skin is the largest area of the body that interfaces with bacteria and "problems" from the environment and is the first line of defence for the body. There are, of course, immune system functions that take place within the skin area and it would be nourished only by the very small arteries (capillaries). So the blood supply at the surface of the skin is not as great as it is further inside the body. When you can apply something on the skin, which nourishes the immune system cells, such as MSM (methylsulfonylmethane) and urea you are doing wonders in improving the health of the skin. The use of urea in dermatological therapy and cosmetics has become more and more important in recent years. However, urea is unstable in formulations, decomposing into carbon dioxide and ammonia. Products containing urea can be stabilised by including MSM (methylsulfonylmethane) in the formulation (Herschler, 1981:l). The aim of this study was to determine the stabilising effect of MSM on urea in cosmetic products. Cosmetic products that were formulated with MSM and urea as actives, comprised of a moisturising lotion, massage cream, foot and heel balm, hair gel, hair spray and lip ice. The formulations were subjected to stability studies for three months under ICH conditions. The formulated products were stored at 5ºC, 25ºC/60%RH and 4OºC/75%RH. The strength of MSM and urea in each formulation was 5% m/m , except for the hair spray and lip ice where the concentrations were 10% m/m and 2.5% m/m respectively. HPLC analysis was used to determine the urea concentrations in all the formulated products, as well as the concentration released during membrane release studies. GC analysis was used to determine the MSM concentrations in the products. Other stability tests included appearance, spreadability, pH, relative density, penetration, viscosity, preservative content and preservative efficacy. Chapter 1 gives a literature overview of the uses and importance of cosmetics. Chapter 2 is a literature overview of the skin and the properties and uses of urea and MSM. Chapter 3 deals with the formulation of urea and MSM products and the chemicals that have been used. Chapter 4 described the methods used for accelerated stability testing. Chapter 5-10 finally deals with the results obtained and the conclusions that were made. The test results showed the following: There was a prominent change in the pH of all the formulated products; this can be due to decomposition of urea into carbon dioxide and ammonia (Beiersdorf, 2003: 1). Higher temperature and moisture increase this decomposition and cause the pH to increase to values as high as 11 (Anon, 2003:20). The viscosity, spreadability, penetration, relative density and appearance of the products remained more or less the same over three months, except for the hair spray where crystals formed in the product that was stored at 5ºC for 1 month due to the menthol in the formulation. The urea and MSM content decreased with time. The lip ice formulation showed concentrations as low as 30% due to poor solubility of the urea and MSM crystals in the waxes of the lip ice formulation. HPLC analysis of the preservatives confirmed their stability in the formulated products. The preservative efficacy results proved that the products were sufficiently protected from microbial contamination. The release study indicated that urea is released at a steady rate from the preparations tested. Urea was released from the moisturising lotion after 120 minutes. In general, the release is influenced by the viscosity of the medium and should be faster from the gel than from the creams or lotion (Shah et al., 199155). In conclusion it can be said that urea and MSM were successfully formulated into the six cosmetic products except for the lip ice, which showed low, unstable concentrations of the actives due to poor solubility of the actives in the waxes of the lip ice formulation. By comparing the results of Claasen, (2003:63) and the results obtained in this study for the hair gel and foot and heel balm, it looks as if MSM had a stabilising effect on urea, by lowering the decrease of urea concentrations over time.
Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2005.
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Haraldsson, Filip, and Jacob Gabrielsson. "Bungle in the jungle : H&Ms kriskommunikation under tröjskandalen i januari 2018." Thesis, Umeå universitet, Institutionen för kultur- och medievetenskaper, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-146608.

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In early January 2018, the clothing company H&M released a new collection for children. One of the sweaters in the collection was printed with the text "Coolest monkey in the jungle". The shirt was worn by a dark-skinned child and H&M was accused of racism. This is because the word "monkey" has historically been used as a racist slur to downgrade dark-skinned people. Throughout the scandal H&M has published an official press release, as well as a number of posts on social media, each of which affects the scandal. The purpose of the study is to analyze H&Ms crisis communication with regard to the strategies they used during the shirt scandal. The main question of the study is how did H&M's crisis communication express itself in text during the shirt scandal. The theories used in the study are William Benoit's image repair theory (2014) and Timothy Coombs Situational crisis communication theory (2007), abbreviated SCCT. The methods used are a qualitative content analysis, text analysis and a rhetorical analysis. The qualitative content analysis is based on the chosen theories, so that the survey can extract the underlying message that H&M wants to convey. While the text analysis processes the text itself and how the company wants the reader to perceive the message and how H&M’s texts interact with each other. The rhetorical analysis contributes to a deeper understanding of the text's underlying message and structure with the actual text as a starting point. The rhetorical analysis is done by analysing the text’s structure with the rhetoric disposition scheme as a starting point. H&M’s crisis communication is in this case related to what is proposed in the strategic theories of crisis communication. The main crisis communication strategies used by H&M were admitting responsibility, asking for forgiveness and corrective actions. The rhetoric analysis has shown that the press release and posts on social media have different functions. The press release make greater importance to the structure of the disposition scheme, while the social media posts rather contain certain parts, for example, a greater focus on pathos and the preparatory of counter arguments while communicating to individuals rather than the public.
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Olsson, Douglas. "FÖRETAGETS SOCIALA ANSVAR : Enkätundersökning av konsumenternas åsikter mot H&Ms sociala ansvar." Thesis, Stockholms universitet, JMK, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-157280.

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Studiens syfte är att göra en kvantitativ undersökning av konsumenternas åsikt mot Corporate Social Responsbility med en avgränsning till modeföretaget H&M med målet är att kunna kartlägga en generaliserande åsikt bland konsumenterna. Till hjälp kommer det användas teorier om CSR, Public Relations och innebörden av Varumärket. Studiens fokus kommer rikta sig mer åt områdena inom CSR som är ekonomisk, socialt och miljömässigt ansvarstagande. Den utvalda metoden för att samla in information var med en webbenkät som skickades ut till utvalda Facebook grupper med inriktningen på mode och skönhet. Enkätens struktur består av fyra delar som inriktar sig på olika områden. Första delen handlar om respondentens vanor kring företaget som sedan följs upp av frågor om H&Ms Image i både reklam och nyhetsmedier. Sedan följs det upp av en CSR del men med andra ordval eftersom alla inte har kunskapen av begreppet CSR och avslutningsvis kommer en demografi del. Majoriteten av de som besvarat enkäten har aldrig läst H&Ms hållbarhetsrapport som finns tillgängligt på deras hemsida. Detta kan bero på omedvetenheten om vad CSR är men det som resultatet indikerar är att de ändå har starka åsikter om H&Ms arbete inom hållbarhet. I både frågorna om arbetsförhållanden och mänskliga rättigheter fanns en tydlig tendens att åsiktenen mot H&M är negativ men när det gäller det miljömässiga ansvarstagandet var det inte lika tydlig. Det skiljde sig även mellan könen då kvinnorna var mer kritiska till detta. Det var även en skillnad mellan olika utbildningsnivåer då högre utbildade var mindre kritiska än dem med en gymnasienivå. När det gäller åsiktenen mot den image som H&M speglar sig själva i sin reklam var det övervägande fler som ansåg att den är positiv än negativ. Denna frågan gav även möjligheten att motivera med egna ord. Svaren var delvis splittrade med att H&Ms reklam är modern men även att de använder sig av stereotypiska smala kvinnor kroppar. Det resultat som studien visar är att konsumenterna anser att H&M bör arbeta mer med sitt sociala ansvarstagande.
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Haglund, Alexandra, and Josefine Oldenstedt. "H&M gör Åhlénstricket : En studie av H&Ms kriskommunikation på Facebook vid lanseringen av barntröjan Coolest monkey in the jungle." Thesis, Umeå universitet, Institutionen för kultur- och medievetenskaper, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-146757.

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This study aims to see how H&M are using crisis communication through Facebook to investigate if they are able to contain their reputation and trustworthiness during and after crisis. This has been done by a quantitative content analysis and the qualitative critical discourse analysis with Norman Fairclough’s three-dimensional model. The study is based on theories relating to crisis communication, brand preservation, ethnicity and rhetoric. The study has been conducted on an official statement H&M made on its Facebook page where 579 comments were analyzed. In the quantitative analysis, three themes emerged from which qualitative research took its starting point to prevent the occurrence of subjective interpretations of the material. In the qualitative analysis, these themes developed and deployed in the categories racism, defense and insultment with subsequent subcategories. These themes were analyzed further in relation to the theoretical framework. H&Ms statement and answers have been analyzed separately. The study found that crises based on trust such as this children's collection probably trigger harder against smaller companies that are more dependent on reputation and credibility than world- leading clothing companies like H&M.
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Sallander, Jacqueline. "När två berättelser blir en : om H&Ms samarbete med Viktor & Rolf." Thesis, Konstfack, Institutionen för Bildpedagogik (BI), 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:konstfack:diva-549.

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Denna undersökning försöker skapa en förståelse för vad som egentligen händer när klädjätten H&M samarbetar med kända modedesigners som Viktor & Rolf, och den paradox som uppstår när det billiga och tillgängliga möter det dyra och exklusiva. Litteraturstudier ger en förståelse för vilka mekanismer som ligger bakom konstruktionen av ett varumärke och dess immateriella berättelse. Genom intervjuer med olika personer synas samarbetet utifrån olika perspektiv. Även konsumenternas berättelsekonstruktion granskas något, för vilka är egentligen dem vi sett springa in på H&M när dörrarna öppnas och slåss över kläder? Vad är det de egentligen köper? Genom ett deltagande i kommershysterin när H&M släpper de åtråvärda kläderna för försäljning, granskas fenomenet på nära håll. Uppsatsen kommer fram till att det är de immateriella berättelserna som är avgörande för den hysteri som kläderna ger upphov till. Kläderna i sig är sekundära. Utan vetskapen om de kända modedesignerna bakom, är de relativt ointressanta. Men även kunderna bidrar själva till att skapa hets genom uppladdning inför köp som bland annat sker på bloggar på internet. Kunderna kan, genom dessa kläder, ikläda sig berättelser och symboler för en händelse, och visa på sitt eget ställningstagande och deltagande i hysterin. Uppsatsen syftar även till att undersöka relevansen i att ta upp sådana här frågor med elever i skolan och kommer fram till att ungdomar, ibland på ett oreflekterat sätt, har ett stort intresse för och kunskap om identitet, livsstilar och kläder. Vem ska lära ungdomar att kritiskt granska marknadskrafter som använder sig av dessa mekanismer om inte lärare och andra vuxna? Gestaltningsarbetet bygger vidare på berättandet som det centrala för kommunikation av design, och låter 6 för omvärlden möjligtvis okända personer spegla sig själva i ett från början (av västerländskt tradition) neutralt plagg som den vita t tröjan, som alterneras efter varje individs önskemål utifrån ett givet material. På så sätt berättas 6 designhistorier.
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Wissenbach, Dirk K. Verfasser], and Hans H. [Akademischer Betreuer] [Maurer. "Development of the first metabolite-based LC-MSⁿ urine drug screening procedure / Dirk K. Wissenbach. Betreuer: Hans H. Maurer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2012. http://d-nb.info/1052292593/34.

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Wissenbach, Dirk K. [Verfasser], and Hans H. [Akademischer Betreuer] Maurer. "Development of the first metabolite-based LC-MSⁿ urine drug screening procedure / Dirk K. Wissenbach. Betreuer: Hans H. Maurer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:291-scidok-47979.

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Luna, Andrew I. "Lateral Resistance of H-Piles and Square Piles Behind an MSE Wall with Ribbed Strip and Welded Wire Reinforcements." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6346.

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Bridges often use pile foundations behind MSE walls to help resist lateral loading from seismic and thermal expansion and contraction loads. Overdesign of pile spacing and sizes occur owing to a lack of design code guidance for piles behind an MSE wall. However, space constraints necessitate the installation of piles near the wall. Full scale lateral load tests were conducted on piles behind an MSE wall. This study involves the testing of four HP12X74 H-piles and four HSS12X12X5/16 square piles. The H-piles were tested with ribbed strip soil reinforcement at a wall height of 15 feet, and the square piles were tested with welded wire reinforcement at a wall height of 20 feet. The H-piles were spaced from the back face of the MSE wall at pile diameters 4.5, 3.2, 2.5, and 2.2. The square piles were spaced at pile diameters 5.7, 4.2, 3.1, and 2.1. Testing was based on a displacement control method where load increments were applied every 0.25 inches up to three inches of pile deflection. It was concluded that piles placed closer than 3.9 pile diameters have a reduction in their lateral resistance. P-multipliers were back-calculated in LPILE from the load-deflection curves obtained from the tests. The p-multipliers were found to be 1.0, 0.85, 0.60, and 0.73 for the H-piles spaced at 4.5, 3.2, 2.5, and 2.2 pile diameters, respectively. The p-multipliers for the square piles were found to be 1.0, 0.77, 0.63, and 0.57 for piles spaced at 5.7, 4.2, 3.1, and 2.1 pile diameters, respectively. An equation was developed to estimate p-multipliers versus pile distance behind the wall. These p-multipliers account for reduced soil resistance, and decrease linearly with distance for piles placed closer than 3.9 pile diameters. Measurements were also taken of the force induced in the soil reinforcement. A statistical analysis was performed to develop an equation that could predict the maximum induced reinforcement load. The main parameters that went into this equation were the lateral pile load, transverse distance from the reinforcement to the pile center normalized by the pile diameter, spacing from the pile center to the wall normalized by the pile diameter, vertical stress, and reinforcement length to height ratio where the height included the equivalent height of the surcharge. The multiple regression equations account for 76% of the variation in observed tensile force for the ribbed strip reinforcement, and 77% of the variation for the welded wire reinforcement. The tensile force was found to increase in the reinforcement as the pile spacing decreased, transverse spacing from the pile decreased, and as the lateral load increased.
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Books on the topic "MSU-H"

1

Pareno, Sam Abede. H. Budi Harijono, Drs. Msi. dalam bingkai media massa. Surabaya: Papyrus, 2004.

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Illnerová, Helena. Circadian rhyt[h]ms in the mammalian pineal gland. Praha: Academia Nakladatelství akademie věd, 1986.

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Jehani, Pelibertus. Pengobatan alternatif radiesthesi medik: Metode Romo H. Loogman, MSC : dialog penyembuhan & cuplikan pengalaman. Jakarta: Putra Siaga Pratama, 2002.

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Biblioteca, Escorial Real, ed. Antología castellana de relatos medievales (Ms. Esc. h-I-13). Buenos Aires: SECRIT, 2008.

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Rees, Smith John, and Escorial Real Biblioteca, eds. The Lives of St. Mary Magdalene and St. Martha (MS Esc. h-I-13). [Exeter]: University of Exeter Press, 1989.

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Mohammad, Al-Asad, and Getty Center for the History of Art and the Humanities., eds. The Topkapı scroll: Geometry and ornament in Islamic architecture : Topkapı Palace Museum Library MS H. 1956. Santa Monica, CA: Getty Center for the History of Art and the Humanities, 1995.

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American Bar Association. Committee on Partnerships and Unincorporated Business Organizations. and American Bar Association. Section of Business Law. Committee on Taxation., eds. The unincorporation, or, Ms. Doolittle, LLC, meets H. Higgens, Inc.: Why can't an LLC be more like a corporation? [Chicago, Ill.]: ABA Section of Business Law, 1999.

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Angela, Mazzè, Anselmo Angela, Zimmardi Maria Carmela, Vergara Caffarelli Francesco, Sicily (Italy). Assessorato regionale dei beni culturali e dell'identità siciliana, and Biblioteca centrale della Regione siciliana, eds. Notizie di artisti siciliani da collocarsi ne' registri secondo l'epoche rispettive, raccolte da Agostino Gallo (Ms. XV. H.20.1-2.). [Palermo, Italy]: Regione siciliana, Assessorato dei beni culturali e dell'identità siciliana, Dipartimento dei beni culturali e dell'identità siciliana, 2014.

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Hascher-Burger, Ulrike. Gesungene Innigkeit: Studien zu einer Musikhandschrift der Devotio moderna (Utrecht, Universiteitsbibliotheek, ms. 16 H 34, olim B 113) : mit einer Edition der Gesnge. Leiden: Brill, 2000.

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Gesungene Innigkeit: Studien zu einer Musikhandschrift der Devotio moderna (Utrecht, Universiteitsbibliotheek, ms. 16 H 34, olim B 113) : mit einer Edition der Gesänge. Leiden [Germany]: Brill, 2002.

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Book chapters on the topic "MSU-H"

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Wang, Ligang, J. William Atwood, and Anjali Agarwal. "Validation of SIP/H.323 Interworking Using SDL/MSC." In SDL 2003: System Design, 335–51. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/3-540-45075-0_20.

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Fernández, Tomás. "El florilegio de los mss. F H en la letra Alfa del Florilegio Coisliniano." In Studies in Byzantine History and Civilization, 213–37. Turnhout, Belgium: Brepols Publishers, 2019. http://dx.doi.org/10.1484/m.sbhc-eb.5.117150.

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Alagić, Ismar. "Application of MSA as a Lean Six Sigma Tool in Working Conditions Automotive Firm from B&H." In Advanced Technologies, Systems, and Applications III, 511–24. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-02577-9_50.

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Wienck, A., I. Boeck, S. Eisold, E. Klar, and M. Linnebacher. "Identification of a MSI-H tumor specific cytotoxic T cell epitope generated by the (−1) frame of U79260(FTO)." In Deutsche Gesellschaft für Chirurgie, 29–30. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00625-8_12.

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Cuppo, Luciana. "Felix of Squillace and the Dionysiac computus I: Bobbio and Northern Italy (MS Ambrosiana H 150 inf.)." In The Easter Controversy of Late Antiquity and the Early Middle Ages. Its Manuscripts, Texts, and Tables, 110–36. Turnhout: Brepols Publishers, 2011. http://dx.doi.org/10.1484/m.stt-eb.1.100731.

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Francomano, Emily C. "‘Lady, you are quite a chatterbox’: The Legend of St Katherine of Alexandria, Wives’ Words, and Women’s Wisdom in MS Escorial h-I-13." In Medieval Women: Texts and Contexts, 131–52. Turnhout: Brepols Publishers, 2003. http://dx.doi.org/10.1484/m.mwtc-eb.3.1913.

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Maeda, Kazuyuki, Katsuya Ichinose, Teruhiro Aikyo, Tsutomu Yamazaki, and Takeyuki Suzuki. "Preparation of MSU-H/anodic alumina-composite membranes." In From Zeolites to Porous MOF Materials - The 40th Anniversary of International Zeolite Conference, Proceedings of the 15th International Zeolite Conference, 1932–37. Elsevier, 2007. http://dx.doi.org/10.1016/s0167-2991(07)81081-0.

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Liu, Yu, and Thomas J. Pinnavaia. "Mesocellular aluminosilicate foams (MSU-S/F) and large pore hexagonal mesostructures (MSU-S/H) assembled from zeolite seeds: hydrothermal stability and properties as cumene cracking catalysts." In Studies in Surface Science and Catalysis, 1075–82. Elsevier, 2002. http://dx.doi.org/10.1016/s0167-2991(02)80265-8.

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Hoon Joo, Sang, Ryong Ryoo, Michal Kruk, and Mietek Jaroniec. "Thermally induced structural changes in SBA-15 and MSU-H silicas and their implications for synthesis of ordered mesoporous carbons." In Nanotechnology in Mesostructured Materials, Proceedings of the 3rd International Materials Symposium, 49–52. Elsevier, 2003. http://dx.doi.org/10.1016/s0167-2991(03)80324-5.

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V. Yefimov, Stanislav. "Rapid Qualitative and Quantitative HPLC/MS Analysis of an Antioxidant Couple Consisted of Glutathione and Ascorbic Acid in a Pharmaceutical Product." In Medicinal Plants. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102975.

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Vitamin C and glutathione are mostly found together in pharmaceutical products. These two components protect each other from oxidation by forming an antioxidant couple and mutually reinforcing each other’s actions. This paper describes a method for determining the activity of the antioxidant couple in pharmaceutical products using HPLC/MS. An Agilent 6125 HPLC equipped with MSD and DAD detectors was used. The first detector is for the detection of glutathione, and the second is for the detection of ascorbic acid. The MS spectrum of glutathione (Glut) was dominated by the signal m / z + = 308.2, which corresponds to the Glut-H + cation. The MS spectrum of ascorbic acid (AA) was dominated by signals m/z + = 177 and 375, which corresponds to the cations AK-H + and 2AK-Na +. The use of HPLC with two detectors (MS and DAD) made it possible to simultaneously determine both components of the antioxidant couple in pharmaceutical products without derivatization and any preliminary sample preparation. The method meets the FDA criteria for accuracy, selectivity, robustness, and reproducibility, and has a low detection limit of both components of the antioxidant couple.
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Conference papers on the topic "MSU-H"

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Alessi, A., G. Buscarino, S. Agnello, L. Sciortino, F. Messina, M. Cannas, F. M. Gelardi, and R. Boscaino. "Aging of MCM41, MSU-H and MSU-F mesoporous systems investigated through the Raman spectroscopy." In FUNDAMENTALS AND APPLICATIONS IN SILICA AND ADVANCED DIELECTRICS (SIO2014): X International Symposium on SiO2, Advanced Dielectrics and Related Devices. AIP Publishing LLC, 2014. http://dx.doi.org/10.1063/1.4900449.

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Magakian, T. Yu, A. M. Tatarnikov, T. A. Movsessian, and H. R. Andreasyan. "Near-infrared detection of H 2 flows in the core of Mon R1 association." In ASTRONOMY AT THE EPOCH OF MULTIMESSENGER STUDIES. Proceedings of the VAK-2021 conference, Aug 23–28, 2021. Crossref, 2022. http://dx.doi.org/10.51194/vak2021.2022.1.1.055.

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We report the discovery of 4 new H 2 jets in Mon R1 star-forming region on the images obtained with the 2.5-m telescopeof the Caucasian Mountain Observatory of SAI MSU through the filter, centered on the H 2 1–0 S(1) emission line. Thisdiscovery confirms the nature of these flows, which existence was previously suspected using archival Spitzer GLIMPSE360and WISE survey images. Also two infrared reflection nebulae were revealed. On the Herschel PACS survey images we founda small group of far-infrared sources, mostly new ones. Among them are the possible exciting objects of these outflows.Spectral energy distributions of new sources show their extremely red colour and the bolometric luminosities reaching 3L ⊙and even 10L ⊙ . Several of them should belong to Class I and even to Class 0 objects.
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"Molecular composition - inhibition activity relationships for humic substances narrow fractions sets obtained by solid-phase extraction." In Sixth International Conference on Humic Innovative Technologies "Humic Substances and Eco-Adaptive Technologies ”(HIT – 2021). Non-Commercial Partnership "Center for Biogenic Resources "Humus Sapiens" (NP CBR "Humus Sapiens"), 2021. http://dx.doi.org/10.36291/hit.2021.mikhnevich.001.

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Humic substances (HS) have a wide spectrum of biological activity including inhibitory activity against β-lactamases.1 The latter are capable of hydrolyzing beta-lactam antibiotics and represent one of the main pathways of bacterial antibiotic resistance. HS are characterized by low toxicity and good solubility in water. A use of HS for therapeutic purposes is hindered by extreme molecular heterogeneity and high level of isomeric complexity. Solid-phase extraction (SPE) fractionation in combination with ultra-high resolution mass spectrometry (FTICR MS) is a promising method to simplify this molecular system and isolate the most active components of HS. The aim of this work was to test various SPE fractionation schemes as an approach to directed isolation of the components with the given activity from HS. The sample of coal humic acids (CHA-G) was isolated from the commercial sodium humate “Genesis” and separated using SPE cartridge according to gradients in polarity1 and acidity2 inherent within the molecular components of HS. Inhibitory activity against β- lactamase TEM-1 and its mutants was measured using chromogenic substrate CENTA. Molecular composition of fractions was determined using FTICR mass spectrometer 15 T solariX (Bruker Daltonics) located at the Collective Use Center of Zelinsky Institute of Organic Chemistry of RAS. Molecular assignments were plotted into van Krevelen diagrams. The diagrams were binned into 20 cells are assigned to seven chemotypes, and occupational densities for each chemotype were calculated after Perminova.3 For the fractions separated by polarity, a substantial difference in the molecular composition was observed. Inhibitory activity grew along with an increase in hydrophobicity. The HS activity increased along with an increase in contribution of condensed tannins and phenylisopropanoids (O/C <0.5, H/C <1.4) and decreased along with contribution of hydrolyzed tannins (O/C> 0.5, H/C <1.4). The similar analysis was conducted for the fractions separated with regard to pKa value of the dominating functional groups. The most isomeric complex molecular components were defined, which can be found in different HS fractions, but they are identical in elemental composition. The data obtained make it possible to choose the most efficient fractionation method that effectively lowers the molecular complexity of HS and makes it possible to isolate the most active HS fractions. SPE-fractionation in combination with 2D chromatography is going to be used in our future studies to achieve high resolution separation and more reliable “molecular composition-activity” relationships. Further research might bring substantial advance in the field of directed design of biologically active humic-based materials and compositions. Acknowledgements. This work was supported by the grant of the Russian Science Foundation no 21-73-20202. The center of collective use of the Zelinsky IOC RAS is appreciated. The research was conducted in the framework of the Scientific-Educational School of the Lomonosov MSU “Future of the plant and global environmental change”. References 1. Mikhnevich et al., ACS Omega, 2021, https://doi.org/10.1021/acsomega.1c02841 2. Zherebker et al., Environ. Sci. Technol. 2020, 54, 2667−2677 3. Perminova, I. V. PAC, 2019, 91(5), 851
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Capasso, Anna, Julie Lang, Todd M. Pitts, Christopher H. Lieu, Scott Kopetz, Sarah L. Davis, Kimberly Jordan, et al. "Abstract A012: Humanized patient-derived xenografts (PDXs) recapitulate clinical responses in microsatellite stable (MSS) and unstable (MSI-H) colorectal cancer (CRC)." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; October 26-30, 2017; Philadelphia, PA. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1535-7163.targ-17-a012.

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Geng, Renkang, Bin Sun, Liyao Ma, Qinjun Zhao, and Tao Shen. "Anomaly Detection in Sequence Data Based on MSM-H with EXPoSE." In 2021 40th Chinese Control Conference (CCC). IEEE, 2021. http://dx.doi.org/10.23919/ccc52363.2021.9549404.

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Wei, Jia, Jian Wang, Xiangshan Fan, Yue Wang, Yao Fu, Kai Wang, Nandie Wu, et al. "Abstract 746: Genomic alteration of Chinese dMMR/MSI-H gastric cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-746.

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Wei, Jia, Jian Wang, Xiangshan Fan, Yue Wang, Yao Fu, Kai Wang, Nandie Wu, et al. "Abstract 746: Genomic alteration of Chinese dMMR/MSI-H gastric cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-746.

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Dooper, Marten. "Second-line avelumab is effective in patients with MSI-H/dMMR mCRC." In ESMO Congress 2022, edited by Stefan Rauh. Baarn, the Netherlands: Medicom Medical Publishers, 2022. http://dx.doi.org/10.55788/c485282f.

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9

Nakamura, Masato R., and Jason Singh. "Effect of Number of Bars and Reciprocation Speed on Residence Time of Particles on a Moving Grate." In 2013 21st Annual North American Waste-to-Energy Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nawtec21-2735.

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The moving grate systems of waste-to-energy (WTE) mass-burn combustion chambers are designed for providing efficient flow and mixing of the municipal solid waste (MSW) over the length of the grade. This study presents results from a numerical analysis of the effect of number of reciprocating bars and reciprocation speed on the degree of mixing and residence time of MSW particles on the grate. A particle-based bed model of MSW and a physical model of reverse-acting grate were used in order to quantify the mixing diffusion coefficient of MSW particles. We analyzed the particle mixing with different parameters: particle size (d = 6–22cm diameter), reciprocation speed of moving bars (Rr = 0–90recip./h), and number of moving bars (Nb = 0 to 16 bars). This combination of mathematical modeling and experimental work has shown that: (1) different particle sizes result in different residence times, according to the Brazil Nut Effect (BNE) (2) The number of moving bars (from 0 to 16 bars) of a reverse-acting grate has the net effect of increasing the mean residence time of small and medium sized particles, while decreasing that of large particles. (3) The bar height, h, was found to be one of the major geometric parameters influencing mixing diffusion coefficient, D, and residence time.
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Yang, Wen, Xing Li, Jinrong Qiu, and Lun Zhou. "Study on Radiation Dose Calculation of PWR Spent Fuel Storage and Transportation." In 2021 28th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/icone28-64457.

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Abstract With the rapid development of nuclear energy, spent fuel will accumulate in large quantities. Spent fuel is generally cooled and placed in a storage pool, and then transported to a reprocessing plant at an appropriate time. Because spent fuel is content with a high level of radiation, spent fuel storage and transportation safety play important roles in the nuclear safety. Radiation dose safety are checked and validated using source analysis and Monte Carlo method to establish a radiation dose rate calculation model for PWR spent fuel storage pool and transport container. The calculation results show that the neutron and photon dose rates decrease exponentially with increase of water level under normal condition of storage pool. The attenuation multiples of neutron and photon dose rates are 4.64 and 1.59, respectively. According to radiation dose levels in different water height situations, spent fuel pool under loss of coolant accident can be divides into five workplaces. They are supervision zone, regular zone, intermittent zone, restricted zone and radiation zone. Under normal condition of transport container, the dose rates at the surface of the container and at a distance of 1 m from the surface are 0.1759 mSv/h and 0.0732 mSv/h, respectively. The dose rates decrease with the increasing radius of break accident, and dose rate at the surface of the transport container is 0.278 mSv/h when the break radius is 20 cm. Transport container conforms to the radiation safety standards of International Atomic Energy Agency (IAEA). This study can provide some reference for radiation safety analysis of spent fuel storage and transportation.
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Reports on the topic "MSU-H"

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Hackett, Wesley, Michael Raviv, Anath Das, Oded Reuveni, and Arie Gutman. Detecting Activity of Juvenile Phase-Specific Translocatable Substances that Influence Rooting Potential Using In Vitro Rooting Assays and Expression of a Specific Gene. United States Department of Agriculture, April 1998. http://dx.doi.org/10.32747/1998.7613038.bard.

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The objectives of the project for which substantial effort was put forth were to: 1) Verify the relationship between expression of a cDNA clone (HW103) and the rooting potential of reciprocally grafted cuttings of juvenile and mature lamina and petioles of Hedera helix L. 2) Detect rooting promoter fractions in exudates from the juvenile leaves of H. Helix by assaying for rooting with leaf petioles of juvenile and mature plants. 3) Isolate, purify and identify compounds which show activity in assays for rooting potential. Some objectives or aspects of the objectives of the original proposal were not pursued for the reasons put forth in the body of the report. The most significant findings of the project are: 1) The MS medium is a better medium than Romberg medium for performing the leaf petiole rooting assay. 2) HW103 gene expression is cell-type specific with higher levels of expression in mature than juvenile phase H. Helix petioles as evidenced by in situ hybridization which suggests a negative relationship between HW103 expression in specific cells involved in root initiation and the lack of rooting potential in mature petioles 3) HW103 gene expression may be lower in mature petioles which had been grafter to a juvenile H. Helix lamina than mature petioles that had been grafted to a mature lamina and this putative lower expression is related to formation of a higher number of roots. 4) HW103 gene expression is not related to auxin induced ethylene production. 5) Two distinct compounds that possess root initiation promoting activity can be detected mainly in diffusate of juvenile H. Helix leaves using mung bean hypocotyls and H. Helix leaf petioles in vitro. 6) H. Helix diffusate active fractions do not insistenlty promote rooting in avocado mini-cuttings. 7) Chemical identification of the active rooting compounds was not accomplished because of the death of Prof. Becker, one of the collaborators, and the resultant loss of his data. These results indicate that these may be a molecular basis for reduced rooting potential in mature H. Helix petioles and that there are diffusible (translocatable) compounds in juvenile H. Helix leaves which promote rooting in juvenile and mature H. Helix petioles and mung bean hypocotyls.
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Author, Not Given. Data summary of municipal solid waste management alternatives. Volume 10, Appendix H: Anaerobic digestion of MSW. Office of Scientific and Technical Information (OSTI), October 1992. http://dx.doi.org/10.2172/10136965.

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Bourdeau, J. E., S. J. A. Day, and S E Zhang. Regional lake sediment geochemical data from northeastern Saskatchewan (NTS 064-E, 074-A and H): re-analysis data and QA/QC evaluation. Natural Resources Canada/CMSS/Information Management, 2022. http://dx.doi.org/10.4095/329875.

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This report presents the geochemical data, quality assurance and quality control (QA/QC) results of the re-analysis of lake sediment samples collected from northeastern Saskatchewan (NTS 064-E, 074-A and H). The original lake survey was conducted in 1984 and the re-analysis in 2021. Original survey results are presented in OF 1643. A total of 1,179 lake sediment samples were re-analyzed, covering an area of 18,000 km2, averaging a density of 1 sample per 13 km2. Samples were measured for 65 elements via modified aqua-regia - ICP-MS. To ensure high quality data, the geochemical data was evaluated for contamination, accuracy, precision and fitness-for-purpose. QA/QC results have identified a number of elements to be monitored carefully for future analyses. Overall, the data is of good quality.
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Bourdeau, J. E., M. W. McCurdy, S. J A Day, and R. G. Garrett. Regional lake sediment geochemical data from north-central Saskatchewan (NTS 074-A, B, G, and H): reanalysis data and QA/QC evaluation. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/329204.

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This report presents the geochemical data, quality assurance and quality control (QA/QC) results of the re-analysis of lake sediment samples collected from north-central Saskatchewan (NTS 074-A, B, G and H). The original lake survey was conducted in 1986 and the re-analysis in 2021. Original survey results are presented in OF1359. A total of 1,290 lake sediment samples were re-analyzed, covering an area of 17,000 km2, averaging a density of 1 sample per 13 km2. Samples were measured for 65 elements via modified aqua-regia - ICP-MS and 35 elements via INA analysis. To ensure high quality data, the geochemical data was evaluated for contamination, accuracy, precision and fitness-for-purpose. QA/QC results have identified a number of elements to be monitored carefully for future analyses. Overall, the data are of good quality.
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Rafaeli, Ada, Wendell Roelofs, and Anat Zada Byers. Identification and gene regulation of the desaturase enzymes involved in sex-pheromone biosynthesis of pest moths infesting grain. United States Department of Agriculture, March 2008. http://dx.doi.org/10.32747/2008.7613880.bard.

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The original objectives of the approved proposal included: 1. Establishment of the biosynthetic pathways for pheromone production using labeled precursors and GC-MS. 2. The elucidation of a circadian regulation of key enzymes in the biosynthetic pathway. 3. The identification, characterization and confirmation of functional expression of the delta-desaturases. 4. The identification of gene regulatory processes involved in the expression of the key enzymes in the biosynthetic pathway. Background to the topic: Moths constitute one of the major groups of pest insects in agriculture and their reproductive behavior is dependent on chemical communication. Sex-pheromone blends are utilized by a variety of moth species to attract conspecific mates. The sex pheromones used are commonly composed of blends of aliphatic molecules that vary in chain length, geometry, degree and position of double bonds and functional groups. They are formed by various actions of specific delta-desaturases to which chain shortening, elongation, reduction, acetylation, and oxidation of a common fatty acyl precursor is coupled. In most of the moth species sex-pheromone biosynthesis is under circadian control by the neurohormone, PBAN (pheromone-biosynthesis-activating neuropeptide). The development of specific and safe insect control strategies utilizing pheromone systems depends on a clear knowledge of the molecular mechanisms involved. In this proposal we aimed at identifying and characterizing specific desaturases involved in the biosynthetic pathway of two moth pest-speciesof stored products, P. interpunctella and S. cerealella, and to elucidate the regulation of the enzymes involved in pheromone biosynthesis. Due to technical difficulties the second stored product pest was excluded from the study at an early phase of the research project. Major conclusions: Within the framework of the planned objectives we confirmed the pheromone biosynthetic pathway of P. interpunctella and H. armigera by using labeled precursor molecules. In addition, in conjunction with various inhibitors we determined the PBAN-stimulated rate-limiting step for these biosynthetic pathways. We thereby present conclusive evidence that the enzyme Acetyl Coenzyme A Carboxylase is activated as a result of PBAN stimulation. We also found that P. interpunctella produce the main pheromone component Z9, E12 Tetradecenyl acetate through the action of a D11 desaturase working on the 16:Acid precursor. This is evidenced by the high amount of incorporation of ²H-labeled 16:Acid into pheromone when compared to the incorporation of ²H-labeled 14:Acid. However, in contrast to reports on other moth species, P. interpunctella is also capable of utilizing the 14:Acid precursor, although to a much lesser extent than the 16:Acid precursor. Despite the discovery of nine different desaturase gene transcripts in this species, from the present study it is evident that although PCR detected all nine gene transcripts, specific to female pheromone glands, only two are highly expressed whereas the other 7 are expressed at levels of at least 10⁵ fold lower showing very low abundance. These two genes correspond to D11-like desaturases strengthening the hypothesis that the main biosynthetic pathway involves a D11 desaturase.
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Borch, Thomas, Yitzhak Hadar, and Tamara Polubesova. Environmental fate of antiepileptic drugs and their metabolites: Biodegradation, complexation, and photodegradation. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7597927.bard.

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Many pharmaceutical compounds are active at very low doses, and a portion of them regularly enters municipal sewage systems and wastewater-treatment plants following use, where they often do not fully degrade. Two such compounds, CBZ and LTG, have been detected in wastewater effluents, surface waters, drinking water, and irrigation water, where they pose a risk to the environment and the food supply. These compounds are expected to interact with organic matter in the environment, but little is known about the effect of such interactions on their environmental fate and transport. The original objectives of our research, as defined in the approved proposal, were to: Determine the rates, mechanisms and products of photodegradation of LTG, CBZ and selected metabolites in waters exposed to near UV light, and the influence of DOM type and binding processes on photodegradation. Determine the potential and pathways for biodegradation of LTG, CBZ and selected metabolites using a white rot fungus (Pleurotusostreatus) and ADP, and reveal the effect of DOM complexation on these processes. Reveal the major mechanisms of binding of LTG, CBZ and selected metabolites to DOM and soil in the presence of DOM, and evaluate the effect of this binding on their photodegradation and/or biodegradation. We determined that LTG undergoes relatively slow photodegradation when exposed to UV light, and that pH affects each of LTG’s ability to absorb UV light, the efficiency of the resulting reaction, and the identities of LTG’sphotoproducts (t½ = 230 to 500 h during summer at latitude 40 °N). We observed that LTG’sphotodegradation is enhanced in the presence of DOM, and hypothesized that LTG undergoes direct reactions with DOM components through nucleophilic substitution reactions. In combination, these data suggest that LTG’s fate and transport in surface waters are controlled by environmental conditions that vary with time and location, potentially affecting the environment and irrigation waters. We determined that P. ostreatusgrows faster in a rich liquid medium (glucose peptone) than on a natural lignocellulosic substrate (cotton stalks) under SSF conditions, but that the overall CBZ removal rate was similar in both media. Different and more varied transformation products formed in the solid state culture, and we hypothesized that CBZ degradation would proceed further when P. ostreatusand the ᵉⁿᶻʸᵐᵃᵗⁱᶜ ᵖʳᵒᶠⁱˡᵉ ʷᵉʳᵉ ᵗᵘⁿᵉᵈ ᵗᵒ ˡⁱᵍⁿⁱⁿ ᵈᵉᵍʳᵃᵈᵃᵗⁱᵒⁿ. ᵂᵉ ᵒᵇˢᵉʳᵛᵉᵈ ¹⁴C⁻Cᴼ2 ʳᵉˡᵉᵃˢᵉ ʷʰᵉⁿ ¹⁴C⁻ᶜᵃʳᵇᵒⁿʸˡ⁻ labeled CBZ was used as the substrate in the solid state culture (17.4% of the initial radioactivity after 63 days of incubation), but could not conclude that mineralization had occurred. In comparison, we determined that LTG does not degrade in agricultural soils irrigated with treated wastewater, but that P. ostreatusremoves up to 70% of LTG in a glucose peptone medium. We detected various metabolites, including N-oxides and glycosides, but are still working to determine the degradation pathway. In combination, these data suggest that P. ostreatuscould be an innovative and effective tool for CBZ and LTG remediation in the environment and in wastewater used for irrigation. In batch experiments, we determined that the sorption of LTG, CBZ and selected metabolites to agricultural soils was governed mainly by SOM levels. In lysimeter experiments, we also observed LTG and CBZ accumulation in top soil layers enriched with organic matter. However, we detected CBZ and one of its metabolites in rain-fed wheat previously irrigated with treated wastewater, suggesting that their sorption was reversible, and indicating the potential for plant uptake and leaching. Finally, we used macroscale analyses (including adsorption/desorption trials and resin-based separations) with molecular- level characterization by FT-ICR MS to demonstrate the adsorptive fractionation of DOM from composted biosolids by mineral soil. This suggests that changes in soil and organic matter types will influence the extent of LTG and CBZ sorption to agricultural soils, as well as the potential for plant uptake and leaching.
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