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Journal articles on the topic 'MsMut1'

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Author: Grafiati

Published: 6 September 2023

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1

Raj, Prateek, S. Karthik, S. M. Arif, U. Varshney, and M. Vijayan. "Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1." Acta Crystallographica Section D Structural Biology 76, no. 10 (September 16, 2020): 982–92. http://dx.doi.org/10.1107/s2059798320010992.

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Mycobacterium smegmatis MutT1 (MsMutT1) is a sanitation enzyme made up of an N-terminal Nudix hydrolase domain and a C-terminal domain resembling a histidine phosphatase. It has been established that the action of MutT1 on 8-oxo-dGTP, 8-oxo-GTP and diadenosine polyphosphates is modulated by intermolecular interactions. In order to further explore this and to elucidate the structural basis of its differential action on 8-oxo-NTPs and unsubstituted NTPs, the crystal structures of complexes of MsMutT1 with 8-oxo-dGTP, GMPPNP and GMPPCP have been determined. Replacement soaking was used in order to ensure that the complexes were isomorphous to one another. Analysis of the structural data led to the elucidation of a relationship between the arrangements of molecules observed in the crystals, molecular plasticity and the action of the enzyme on nucleotides. The dominant mode of arrangement involving a head-to-tail sequence predominantly leads to the generation of NDPs. The other mode of packing arrangement appears to preferentially generate NMPs. This work also provides interesting insights into the dependence of enzyme action on the conformation of the ligand. The possibility of modulating the enzyme action through differences in intermolecular interactions and ligand conformations makes MsMutT1 a versatile enzyme.

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2

Liu, Feixiang, and Yiru Dai. "Product Processing Quality Classification Model for Small-Sample and Imbalanced Data Environment." Computational Intelligence and Neuroscience 2022 (March 24, 2022): 1–16. http://dx.doi.org/10.1155/2022/9024165.

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With the rapid development of machine learning technology, how to use machine learning technology to empower the manufacturing industry has become a research hotspot. In order to solve the problem of product quality classification in a small sample data and imbalanced data environment, this paper proposes a data generation model called MSMOTE-GAN, which is based on Mahalanobis Synthetic Minority Oversampling Technology (MSMOTE) and Generative Adversarial Network (GAN). Among them, MSMOTE is proposed to solve the problem of the sample biased to the majority class expanded by methods such as GAN in a sample imbalanced environment. Based on the traditional SMOTE method, the sample distance measurement method is modified from Euclidean distance to Mahalanobis distance, taking into account the correlation between attributes and the influence of dimensions on the sample distance. In the data generation model, MSMOTE is used to balance the positive and negative samples in the data. GAN generates fake data with the same distribution as the original data based on a balanced data set and expands the sample size to solve the problems of overfitting and insufficient model expression ability that occur when the sample size is too small. The quality classification framework of water heater liner based on the data generation model and Random Forest is constructed, and the process of the quality classification of water heater liner under the environment of small sample data and imbalanced data is fully described. This paper compares the MSMOTE-GAN model, Bootstrap, and tableGAN on the water heater liner production line data set and the public data set. The experimental result shows that the expanded data set of the MSMOTE-GAN model can effectively improve the performance of the classification model.

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3

Pybus, Oliver G., Andrew Rambaut, Robert Belshaw, Robert P. Freckleton, Alexei J. Drummond, and Edward C. Holmes. "Phylogenetic Evidence for Deleterious Mutation Load in RNA Viruses and Its Contribution to Viral Evolution." Molecular Biology and Evolution 24, no. 3 (January 11, 2007): 845–52. http://dx.doi.org/10.1093/molbev/msm001.

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4

Yuan, Q., D. Metterville, A. D. Briscoe, and S. M. Reppert. "Insect Cryptochromes: Gene Duplication and Loss Define Diverse Ways to Construct Insect Circadian Clocks." Molecular Biology and Evolution 24, no. 4 (January 30, 2007): 948–55. http://dx.doi.org/10.1093/molbev/msm011.

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5

Seoighe, C., F. Ketwaroo, V. Pillay, K. Scheffler, N. Wood, R. Duffet, M. Zvelebil, et al. "A Model of Directional Selection Applied to the Evolution of Drug Resistance in HIV-1." Molecular Biology and Evolution 24, no. 4 (January 30, 2007): 1025–31. http://dx.doi.org/10.1093/molbev/msm021.

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6

Gentle, I. E., A. J. Perry, F. H. Alcock, V. A. Likic, P. Dolezal, E. T. Ng, A. W. Purcell, et al. "Conserved Motifs Reveal Details of Ancestry and Structure in the Small TIM Chaperones of the Mitochondrial Intermembrane Space." Molecular Biology and Evolution 24, no. 5 (February 13, 2007): 1149–60. http://dx.doi.org/10.1093/molbev/msm031.

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7

He, Chaoying, Hans Sommer, Britta Grosardt, Peter Huijser, and Heinz Saedler. "PFMAGO, a MAGO NASHI-Like Factor, Interacts with the MADS-Domain Protein MPF2 from Physalis floridana." Molecular Biology and Evolution 24, no. 5 (March 5, 2007): 1229–41. http://dx.doi.org/10.1093/molbev/msm041.

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8

Webster, M. T., and J. Hagberg. "Is There Evidence for Convergent Evolution around Human Microsatellites?" Molecular Biology and Evolution 24, no. 5 (February 13, 2007): 1097–100. http://dx.doi.org/10.1093/molbev/msm051.

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9

Xing, Yi, Zhengqing Ouyang, Karen Kapur, Matthew P. Scott, and Wing Hung Wong. "Assessing the Conservation of Mammalian Gene Expression Using High-Density Exon Arrays." Molecular Biology and Evolution 24, no. 6 (March 25, 2007): 1283–85. http://dx.doi.org/10.1093/molbev/msm061.

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10

Dawson, D. A., M. Akesson, T. Burke, J. M. Pemberton, J. Slate, and B. Hansson. "Gene Order and Recombination Rate in Homologous Chromosome Regions of the Chicken and a Passerine Bird." Molecular Biology and Evolution 24, no. 7 (March 8, 2007): 1537–52. http://dx.doi.org/10.1093/molbev/msm071.

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11

Yang, Z. "Fair-Balance Paradox, Star-tree Paradox, and Bayesian Phylogenetics." Molecular Biology and Evolution 24, no. 8 (April 18, 2007): 1639–55. http://dx.doi.org/10.1093/molbev/msm081.

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12

Nozaki, Hisayoshi, Mineo Iseki, Masami Hasegawa, Kazuharu Misawa, Takashi Nakada, Narie Sasaki, and Masakatsu Watanabe. "Phylogeny of Primary Photosynthetic Eukaryotes as Deduced from Slowly Evolving Nuclear Genes." Molecular Biology and Evolution 24, no. 8 (May 7, 2007): 1592–95. http://dx.doi.org/10.1093/molbev/msm091.

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13

Khan, H., N. Parks, C. Kozera, B. A. Curtis, B. J. Parsons, S. Bowman, and J. M. Archibald. "Plastid Genome Sequence of the Cryptophyte Alga Rhodomonas salina CCMP1319: Lateral Transfer of Putative DNA Replication Machinery and a Test of Chromist Plastid Phylogeny." Molecular Biology and Evolution 24, no. 8 (April 18, 2007): 1832–42. http://dx.doi.org/10.1093/molbev/msm101.

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14

Becq, J., M. C. Gutierrez, V. Rosas-Magallanes, J. Rauzier, B. Gicquel, O. Neyrolles, and P. Deschavanne. "Contribution of Horizontally Acquired Genomic Islands to the Evolution of the Tubercle Bacilli." Molecular Biology and Evolution 24, no. 8 (April 18, 2007): 1861–71. http://dx.doi.org/10.1093/molbev/msm111.

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15

Chung, Ho-Ryun, Ulrike Löhr, and Herbert Jäckle. "Lineage-specific expansion of the Zinc Finger Associated Domain ZAD." Molecular Biology and Evolution 24, no. 9 (June 14, 2007): 1934–43. http://dx.doi.org/10.1093/molbev/msm121.

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16

Kolaczkowski, Bryan, and Joseph W. Thornton. "Effects of Branch Length Uncertainty on Bayesian Posterior Probabilities for Phylogenetic Hypotheses." Molecular Biology and Evolution 24, no. 9 (July 17, 2007): 2108–18. http://dx.doi.org/10.1093/molbev/msm141.

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17

De Kee, Danny W., Vivek Gopalan, and Arlin Stoltzfus. "A Sequence-Based Model Accounts Largely for the Relationship of Intron Positions to Protein Structural Features." Molecular Biology and Evolution 24, no. 10 (July 23, 2007): 2158–68. http://dx.doi.org/10.1093/molbev/msm151.

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18

He, J., D. M. Irwin, and Y. p. Zhang. "Insights into the evolution of themotilin/ghrelin-associated family and their receptors." Molecular Biology and Evolution 26, no. 3 (December 23, 2008): NP. http://dx.doi.org/10.1093/molbev/msm161.

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19

Sutherland, T. D., S. Weisman, H. E. Trueman, A. Sriskantha, J. W. H. Trueman, and V. S. Haritos. "Conservation of Essential Design Features in Coiled Coil Silks." Molecular Biology and Evolution 24, no. 11 (August 16, 2007): 2424–32. http://dx.doi.org/10.1093/molbev/msm171.

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20

Sellis, Diamantis, Astero Provata, and Yannis Almirantis. "Alu and LINE1 Distributions in the Human Chromosomes: Evidence of Global Genomic Organization Expressed in the Form of Power Laws." Molecular Biology and Evolution 24, no. 11 (August 29, 2007): 2385–99. http://dx.doi.org/10.1093/molbev/msm181.

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21

Hikosaka, Akira, Toshihiro Kobayashi, Yumiko Saito, and Akira Kawahara. "Evolution of the Xenopus piggyBac Transposon Family TxpB: Domesticated and Untamed Strategies of Transposon Subfamilies." Molecular Biology and Evolution 24, no. 12 (October 13, 2007): 2648–56. http://dx.doi.org/10.1093/molbev/msm191.

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Abstract A new family, termed TxpB, of DNA transposons belonging to the piggyBac superfamily was found in 3 Xenopus species (Xenopus tropicalis, Xenopus laevis, and Xenopus borealis). Two TxpB subfamilies of Kobuta and Uribo1 were found in all the 3 species, and another subfamily termed Uribo2 was found in X. tropicalis. Molecular phylogenetic analyses of their open reading frames (ORFs) revealed that TxpB transposons have been maintained for over 100 Myr. Both the Uribo1 and the Uribo2 ORFs were present as multiple copies in each genome, and some of them were framed by terminal inverted repeat sequences. In contrast, all the Kobuta ORFs were present as a single copy in each genome and exhibited high evolutionary conservation, suggesting domestication of Kobuta genes by the host. Genomic insertion polymorphisms of the Uribo1 and Uribo2 transposons (nonautonomous type) were observed in a single species of X. tropicalis, indicating recent transposition events. Transfection experiments in cell culture revealed that an expression vector construct for the intact Uribo2 ORF caused precise excision of a nonautonomous Uribo2 element from the target vector construct but that for the Kobuta ORF did not. The present results support our viewpoint that some Uribo2 members are naturally active autonomous transposons, whereas Kobuta members may be domesticated by hosts.

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22

Moller-Krull, M., F. Delsuc, G. Churakov, C. Marker, M. Superina, J. Brosius, E. J. P. Douzery, and J. Schmitz. "Retroposed Elements and Their Flanking Regions Resolve the Evolutionary History of Xenarthran Mammals (Armadillos, Anteaters, and Sloths)." Molecular Biology and Evolution 24, no. 11 (August 16, 2007): 2573–82. http://dx.doi.org/10.1093/molbev/msm201.

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23

Schlegel, T., O. Mirus, A. von Haeseler, and E. Schleiff. "The Tetratricopeptide Repeats of Receptors Involved in Protein Translocation across Membranes." Molecular Biology and Evolution 24, no. 12 (June 29, 2007): 2763–74. http://dx.doi.org/10.1093/molbev/msm211.

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24

Casola, C., D. Hucks, and C. Feschotte. "Convergent Domestication of pogo-like Transposases into Centromere-Binding Proteins in Fission Yeast and Mammals." Molecular Biology and Evolution 25, no. 1 (November 13, 2007): 29–41. http://dx.doi.org/10.1093/molbev/msm221.

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25

Cusimano, N., L. B. Zhang, and S. S. Renner. "Reevaluation of the cox1 Group I Intron in Araceae and Angiosperms Indicates a History Dominated by Loss rather than Horizontal Transfer." Molecular Biology and Evolution 25, no. 2 (January 2, 2008): 265–76. http://dx.doi.org/10.1093/molbev/msm241.

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26

Zhang, Z. D., P. Cayting, G. Weinstock, and M. Gerstein. "Analysis of Nuclear Receptor Pseudogenes in Vertebrates: How the Silent Tell Their Stories." Molecular Biology and Evolution 25, no. 1 (November 13, 2007): 131–43. http://dx.doi.org/10.1093/molbev/msm251.

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27

Karro, J. E., M. Peifer, R. C. Hardison, M. Kollmann, and H. H. von Grünberg. "Exponential Decay of GC Content Detected by Strand-Symmetric Substitution Rates Influences the Evolution of Isochore Structure." Molecular Biology and Evolution 25, no. 2 (November 27, 2007): 362–74. http://dx.doi.org/10.1093/molbev/msm261.

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28

Burridge, C. P., D. Craw, D. Fletcher, and J. M. Waters. "Geological Dates and Molecular Rates: Fish DNA Sheds Light on Time Dependency." Molecular Biology and Evolution 25, no. 4 (February 14, 2008): 624–33. http://dx.doi.org/10.1093/molbev/msm271.

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29

Kim, S. H., and S. V. Yi. "Mammalian Nonsynonymous Sites Are Not Overdispersed: Comparative Genomic Analysis of Index of Dispersion of Mammalian Proteins." Molecular Biology and Evolution 25, no. 4 (February 14, 2008): 634–42. http://dx.doi.org/10.1093/molbev/msm281.

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30

Bozorgtabar, Behzad, and Roland Goecke. "MSMCT: Multi-State Multi-Camera Tracker." IEEE Transactions on Circuits and Systems for Video Technology 28, no. 12 (December 2018): 3361–76. http://dx.doi.org/10.1109/tcsvt.2017.2755038.

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31

Yan, Xiai, Shengkai Ding, Wei Zhou, Weiqi Shi, and Hua Tian. "Unsupervised Domain Adaptive Person Re-Identification Method Based on Transformer." Electronics 11, no. 19 (September 27, 2022): 3082. http://dx.doi.org/10.3390/electronics11193082.

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Person re-identification (ReID) is the problem of cross-camera target retrieval. The extraction of robust and discriminant features is the key factor in realizing the correct correlation of targets. A model based on convolutional neural networks (CNNs) can extract more robust image features. Still, it completes the extraction of images from local information to global information by continuously accumulating convolution layers. As a complex CNN, a vision transformer (ViT) captures global information from the beginning to extract more powerful features. This paper proposes an unsupervised domain adaptive person re-identification model (ViTReID) based on the vision transformer, taking the ViT model trained on ImageNet as the pre-training weight and a transformer encoder as the feature extraction network, which makes up for some defects of the CNN model. At the same time, the combined loss function of cross-entropy and triplet loss function combined with the center loss function is used to optimize the network; the person’s head is evaluated and trained as a local feature combined with the global feature of the whole body, focusing on the head, to enhance the head feature information. The experimental results show that ViTReID exceeds the baseline method (SSG) by 14% (Market1501 → MSMT17) in mean average precision (mAP). In MSMT17 → Market1501, ViTReID is 1.2% higher in rank-1 (R1) accuracy than a state-of-the-art method (SPCL); in PersonX → MSMT17, the mAP is 3.1% higher than that of the MMT-dbscan method, and in PersonX → Market1501, the mAP is 1.5% higher than that of the MMT-dbscan method.

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32

Min, Xueyang, Xiaoyu Jin, Wenxian Liu, Xingyi Wei, Zhengshe Zhang, Boniface Ndayambaza, and Yanrong Wang. "Transcriptome-wide characterization and functional analysis of MATE transporters in response to aluminum toxicity in Medicago sativa L." PeerJ 7 (January 31, 2019): e6302. http://dx.doi.org/10.7717/peerj.6302.

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Multidrug and toxic compound extrusion (MATE) transporters contribute to multidrug resistance and play major determinants of aluminum (Al) tolerance in plants. Alfalfa (Medicago sativa L.) is the most extensively cultivated forage crop in the world, yet most alfalfa cultivars are not Al tolerant. The basic knowledge of the MATE transcripts family and the characterisation of specific MATE members involved in alfalfa Al stress remain unclear. In this study, 88 alfalfa MATE (MsMATE) transporters were identified at the whole transcriptome level. Phylogenetic analysis classified them into four subfamilies comprising 11 subgroups. Generally, five kinds of motifs were found in group G1, and most were located at the N-terminus, which might confer these genes with Al detoxification functions. Furthermore, 10 putative Al detoxification-related MsMATE genes were identified and the expression of five genes was significantly increased after Al treatment, indicating that these genes might play important roles in conferring Al tolerance to alfalfa. Considering the limited functional understanding of MATE transcripts in alfalfa, our findings will be valuable for the functional investigation and application of this family in alfalfa.

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33

Li, Guang, Peng Liu, Xiaofan Cao, and Chunguang Liu. "Dynamic Weighting Network for Person Re-Identification." Sensors 23, no. 12 (June 14, 2023): 5579. http://dx.doi.org/10.3390/s23125579.

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Recently, hybrid Convolution-Transformer architectures have become popular due to their ability to capture both local and global image features and the advantage of lower computational cost over pure Transformer models. However, directly embedding a Transformer can result in the loss of convolution-based features, particularly fine-grained features. Therefore, using these architectures as the backbone of a re-identification task is not an effective approach. To address this challenge, we propose a feature fusion gate unit that dynamically adjusts the ratio of local and global features. The feature fusion gate unit fuses the convolution and self-attentive branches of the network with dynamic parameters based on the input information. This unit can be integrated into different layers or multiple residual blocks, which will have varying effects on the accuracy of the model. Using feature fusion gate units, we propose a simple and portable model called the dynamic weighting network or DWNet, which supports two backbones, ResNet and OSNet, called DWNet-R and DWNet-O, respectively. DWNet significantly improves re-identification performance over the original baseline, while maintaining reasonable computational consumption and number of parameters. Finally, our DWNet-R achieves an mAP of 87.53%, 79.18%, 50.03%, on the Market1501, DukeMTMC-reID, and MSMT17 datasets. Our DWNet-O achieves an mAP of 86.83%, 78.68%, 55.66%, on the Market1501, DukeMTMC-reID, and MSMT17 datasets.

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34

Lin, Ronghui, Rong Wang, Wenjing Zhang, Ao Wu, Yang Sun, and Yihan Bi. "Person Re-Identification Method Based on Dual Descriptor Feature Enhancement." Entropy 25, no. 8 (August 1, 2023): 1154. http://dx.doi.org/10.3390/e25081154.

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Person re-identification is a technology used to identify individuals across different cameras. Existing methods involve extracting features from an input image and using a single feature for matching. However, these features often provide a biased description of the person. To address this limitation, this paper introduces a new method called the Dual Descriptor Feature Enhancement (DDFE) network, which aims to emulate the multi-perspective observation abilities of humans. The DDFE network uses two independent sub-networks to extract descriptors from the same person image. These descriptors are subsequently combined to create a comprehensive multi-view representation, resulting in a significant improvement in recognition performance. To further enhance the discriminative capability of the DDFE network, a carefully designed training strategy is employed. Firstly, the CurricularFace loss is introduced to enhance the recognition accuracy of each sub-network. Secondly, the DropPath operation is incorporated to introduce randomness during sub-network training, promoting difference between the descriptors. Additionally, an Integration Training Module (ITM) is devised to enhance the discriminability of the integrated features. Extensive experiments are conducted on the Market1501 and MSMT17 datasets. On the Market1501 dataset, the DDFE network achieves an mAP of 91.6% and a Rank1 of 96.1%; on the MSMT17 dataset, the network achieves an mAP of 69.9% and a Rank1 of 87.5%. These outcomes outperform most SOTA methods, highlighting the significant advancement and effectiveness of the DDFE network.

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35

Lee, Il Hwan, Do Hyun Kim, Soo Whan Kim, Jun-Beom Park, and Sung Won Kim. "An Anatomic Study on the Maxillary Sinus Mucosal Thickness and the Distance between the Maxillary Sinus Ostium and Sinus Floor for the Maxillary Sinus Augmentation." Medicina 56, no. 9 (September 14, 2020): 470. http://dx.doi.org/10.3390/medicina56090470.

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Background and objectives: The average rate of chronic sinusitis after maxillary implantation was approximately 5.1%. However, the evidence of predictive risk factors for sinusitis after implantation is lacking. The aim of this study was to perform an anatomic study on the maxillary sinus mucosal thickness (MSMT), the distance between the maxillary sinus ostium and sinus floor (MOD), and the MSMT/MOD ratio as a preoperative risk indicator for sinusitis after maxillary dental implantation. Materials and Methods: Between October 2008 and October 2019, all patients referred to the otolaryngology department were included in this study. A total of 120 patients were enrolled. The 95 patients who received no treatment prior to implantation were classified into Group A, the 16 patients who used antibiotics before implantation were classified into Group B, and the patients who had implants inserted after functional endoscopic sinus surgery were classified into Group C. The MSMT, MOD, MSMT/MOD ratio, anatomical factors associated with ostial obstruction, and the occurrence of postoperative sinusitis were reviewed. Results: There were significant group differences in MSMT (Group A vs. Group B, p = 0.001; Group B vs. Group C, p = 0.003; Group C vs. Group A, p < 0.0001). The MOD showed no significant difference among the three groups. The MSMT/MOD ratio showed significant differences between Groups A and B (p = 0.001), B and C (p < 0.0001), and C and A (p < 0.0001). Conclusions: It is important to check not only the proportion of the maxillary sinus occupying lesion, but also the status of the maxillary sinus osteomeatal complex when making therapeutic decisions. In addition, collaboration between dentists and otolaryngologists could improve outcomes in patients with maxillary sinus lesions.

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36

Morales, J. Andres, Cynthia J. Curry, Christina G. Tise, Lisa Kratz, and Gregory M. Enns. "Clinical characterization of a new individual with mild SC4MOL deficiency: diagnostic and therapeutic implications." Journal of Translational Genetics and Genomics 6 (2022): 257–65. http://dx.doi.org/10.20517/jtgg.2022.01.

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Sterol C4-methyloxidase-like (SC4MOL) deficiency is an autosomal recessive condition caused by biallelic pathogenic variants in MSMO1, resulting in the accumulation of 4-monomethyl and 4,4′-dimethyl sterols due to an enzymatic block in the cholesterol synthesis pathway. SC4MOL deficiency was first reported in 2011, with only seven additional cases from five unrelated families described in the literature since. Based on these reports, the most characteristic clinical features include the triad of microcephaly, congenital cataracts, and psoriatic dermatitis, followed by delayed growth and puberty, and neurodevelopmental problems. Herein, we describe an 8-year-old boy who presented with congenital cataracts and developmental delay at age 6 months and was found to have biallelic variants in MSMO1 by trio exome sequencing. Initial total methylsterol levels were elevated but responsive to statin therapy, while total cholesterol levels remained normal throughout. Available clinical and biochemical data suggest this individual could represent the mildest case of SC4MOL deficiency to date.

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37

Kalay Yildizhan, Incilay, Ezgi Gökpınar İli, Alexandros Onoufriadis, Pelin Kocyigit, Evangelia Kesidou, Michael A. Simpson, John A. McGrath, Nüket Yürür Kutlay, and Nihal Kundakci. "New Homozygous Missense MSMO1 Mutation in Two Siblings with SC4MOL Deficiency Presenting with Psoriasiform Dermatitis." Cytogenetic and Genome Research 160, no. 9 (2020): 523–30. http://dx.doi.org/10.1159/000511126.

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Sterol-C4-methyl oxidase (SC4MOL) deficiency was recently described as an autosomal recessive cholesterol biosynthesis disorder caused by mutations in the <i>MSMO1</i> (sometimes also referred to as <i>SC4MOL</i>) gene. To date, 5 patients from 4 unrelated families with SC4MOL deficiency have been reported. Diagnosis can be challenging as the biochemical accumulation of methylsterols can affect global development and cause skin and ocular pathology. Herein, we describe 2 siblings from a consanguineous Turkish family with SC4MOL deficiency presenting with psoriasiform dermatitis, ocular abnormalities (nystagmus, optic hypoplasia, myopia, and strabismus), severe intellectual disability, and growth and motor delay. We undertook whole-exome sequencing and identified a new homozygous missense mutation c.81A>C; p.Asn27Thr in <i>MSMO1</i>. Segregation analysis in all available family members confirmed recessive inheritance of the mutation. The siblings were treated with a combination of oral and topical statin and cholesterol which resulted in clinical improvement. This study demonstrates how genomics-based diagnosis and therapy can be helpful in clinical practice.

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38

Chiaravalloti, Nancy D., Nancy B. Moore, and John DeLuca. "The efficacy of the modified Story Memory Technique in progressive MS." Multiple Sclerosis Journal 26, no. 3 (February 11, 2019): 354–62. http://dx.doi.org/10.1177/1352458519826463.

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Background: Impairments in new learning and memory are common in individuals with multiple sclerosis (MS), negatively impacting everyday life, including occupational and social functioning. Objective: This study examined the efficacy of the modified Story Memory Technique (mSMT) in a progressive multiple sclerosis (PMS) sample through a double-blind, placebo-controlled, randomized clinical trial (RCT). Methods: Thirty (30) individuals with PMS, naïve to the mSMT, were randomized to the treatment or placebo control group. The Treatment Group completed mSMT training twice per week for 5 weeks while the Placebo Group met with the therapist at the same frequency, engaging in non-training-oriented tasks to control for professional contact and disease alterations. Results: The treatment group showed significant improvements in learning compared with the placebo control group, evident on both objective evaluation of new learning and self-report of functioning in daily life. Increased awareness of cognitive deficits was also noted post-treatment. Conclusion: These data provide Class I evidence supporting the efficacy of the mSMT in PMS. A behavioral intervention, targeted to specifically strengthen new learning, can significantly improve memory performance in PMS, and this improvement in memory performance is maintained 3 months later.

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39

Ribet, David, Francis Harper, Cécile Esnault, Gérard Pierron, and Thierry Heidmann. "The GLN Family of Murine Endogenous Retroviruses Contains an Element Competent for Infectious Viral Particle Formation." Journal of Virology 82, no. 9 (February 20, 2008): 4413–19. http://dx.doi.org/10.1128/jvi.02141-07.

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ABSTRACT Several families of endogenous retroviruses (ERVs) have been identified in the mouse genome, in several instances by in silico searches, but for many of them it remains to be determined whether there are elements that can still encode functional retroviral particles. Here, we identify, within the GLN family of highly reiterated ERVs, one, and only one, copy that encodes retroviral particles prone to infection of mouse cells. We show that its envelope protein confers an ecotropic host range and recognizes a receptor different from mCAT1 and mSMIT1, the two previously identified receptors for other ecotropic mouse retroviruses. Electron microscopy disclosed viral particle assembly and budding at the cell membrane, as well as release of mature particles into the extracellular space. These particles are closely related to murine leukemia virus (MLV) particles, with which they have most probably been confused in the past. This study, therefore, identifies a new class of infectious mouse ERVs belonging to the family Gammaretroviridae, with one family member still functional today. This family is in addition to the two MLV and mouse mammary tumor virus families of active mouse ERVs with an extracellular life cycle.

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Cao, Rongxian, Zhiqiang Zhang, Chen Tian, WeiWei Sheng, Qi Dong, and Ming Dong. "Down-regulation of MSMO1 promotes the development and progression of pancreatic cancer." Journal of Cancer 13, no. 10 (2022): 3013–21. http://dx.doi.org/10.7150/jca.73112.

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Schroor, Maite M., Fatma B. A. Mokhtar, Jogchum Plat, and Ronald P. Mensink. "Associations between SNPs in Intestinal Cholesterol Absorption and Endogenous Cholesterol Synthesis Genes with Cholesterol Metabolism." Biomedicines 9, no. 10 (October 14, 2021): 1475. http://dx.doi.org/10.3390/biomedicines9101475.

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Single nucleotide polymorphisms (SNPs) have been associated with cholesterol metabolism and may partly explain large inter-individual variability in intestinal cholesterol absorption and endogenous cholesterol synthesis rates. This cross-sectional study therefore examined whether SNPs in genes encoding for proteins involved in intestinal cholesterol absorption (ABCG5, ABCG8, and NPC1L1) and endogenous cholesterol synthesis (CYP51A1, DHCR7, DHCR24, HMGCR, HSD17B7, LBR, and MSMO1) were associated with intestinal cholesterol absorption markers (total cholesterol (TC) standardized campesterol and sitosterol levels), an endogenous cholesterol synthesis marker (TC-standardized lathosterol levels), and serum low-density lipoprotein cholesterol (LDL-C) concentrations in a European cohort. ABCG5 (rs4245786) and the tag SNP ABCG8 (rs4245791) were significantly associated with serum campesterol and/or sitosterol levels. In contrast, NPC1L1 (rs217429 and rs217416) were significantly associated with serum lathosterol levels. The tag SNP in HMGCR (rs12916) and a SNP in LBR (rs12141732) were significantly associated with serum LDL-C concentrations. SNPs in the cholesterol absorption genes were not associated with serum LDL-C concentrations. SNPs in CYP51A1, DHCR24, HSD17B7, and MSMO1 were not associated with the serum non-cholesterol sterols and LDL-C concentrations. Given the variable efficiency of cholesterol-lowering interventions, the identification of SNPs associated with cholesterol metabolism could be a step forward towards personalized approaches.

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Zeng, Yi Dan, Zhi Feng Zhang, Jun Xu, and Li Kai Shi. "The MSMT Process for Semi-Solid Slurry Production." Solid State Phenomena 141-143 (July 2008): 421–26. http://dx.doi.org/10.4028/www.scientific.net/ssp.141-143.421.

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A new slurry making method for rheocasting termed “Melt Spreading and Mixing Technique” (MSMT), based on forced uniform solidification theory, has been proposed, by which the bulk metal is dispersed into thin liquid film that is cooled rapidly and uniformly to allow copious nucleation. With a model alloy Al-wt%6.5Si to conduct a series of experiments, feasibility of this method and influence of process parameters upon slurry microstructure were studied. The results show that semisolid slurry for mass production with uniformly fine nondendritic microstructures can be obtained consistently and continuously by optimizing process parameters.

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Gillam, Tony. "The writing cureThe writing cure Stephen J Lepore and Joshua MSmyth American Psychological AssociationFirst314£19.63 (hardback)15579891091557989109." Mental Health Practice 7, no. 7 (April 2004): 24. http://dx.doi.org/10.7748/mhp.7.7.24.s18.

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Lang, Wenjie, Chaonan Yuan, Biwei Zhu, Sijun Pan, Jian Liu, Jie Luo, Shikun Nie, Qing Zhu, Jun-Seok Lee, and Jingyan Ge. "Expanding the “minimalist” small molecule tagging approach to different bioactive compounds." Organic & Biomolecular Chemistry 17, no. 11 (2019): 3010–17. http://dx.doi.org/10.1039/c8ob03175d.

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Harlim, John, and Andrew J. Majda. "Filtering Turbulent Sparsely Observed Geophysical Flows." Monthly Weather Review 138, no. 4 (April 1, 2010): 1050–83. http://dx.doi.org/10.1175/2009mwr3113.1.

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Abstract Filtering sparsely turbulent signals from nature is a central problem of contemporary data assimilation. Here, sparsely observed turbulent signals from nature are generated by solutions of two-layer quasigeostrophic models with turbulent cascades from baroclinic instability in two separate regimes with varying Rossby radius mimicking the atmosphere and the ocean. In the “atmospheric” case, large-scale turbulent fluctuations are dominated by barotropic zonal jets with non-Gaussian statistics while the “oceanic” case has large-scale blocking regime transitions with barotropic zonal jets and large-scale Rossby waves. Recently introduced, cheap radical linear stochastic filtering algorithms utilizing mean stochastic models (MSM1, MSM2) that have judicious model errors are developed here as well as a very recent cheap stochastic parameterization extended Kalman filter (SPEKF), which includes stochastic parameterization of additive and multiplicative bias corrections “on the fly.” These cheap stochastic reduced filters as well as a local least squares ensemble adjustment Kalman filter (LLS-EAKF) are compared on the test bed with 36 sparse regularly spaced observations for their skill in recovering turbulent spectra, spatial pattern correlations, and RMS errors. Of these four algorithms, the cheap SPEKF algorithm has the superior overall skill on the stringent test bed, comparable to LLS-EAKF in the atmospheric regime with and without model error and far superior to LLS-EAKF in the ocean regime. LLS-EAKF has special difficulty and high computational cost in the ocean regime with small Rossby radius, which creates stiffness in the perfect dynamics. The even cheaper mean stochastic model, MSM1, has high skill, which is comparable to SPEKF for the oceanic case while MSM2 has significantly worse filtering performance than MSM1 with the same inexpensive computational cost. This is interesting because MSM1 is based on a simple new regression strategy while MSM2 relies on the conventional regression strategy used in stochastic models for shear turbulence.

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Weaver, Merle L., and H. Timm. "Influence of Temperature and Plant Water Status on Pollen Viability in Beans." Journal of the American Society for Horticultural Science 113, no. 1 (January 1988): 31–35. http://dx.doi.org/10.21273/jashs.113.1.31.

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Abstract The effect of temperature, soil moisture, and diurnal variations in plant water content on pollen viability (PV) in bean (Phaseolus vulgaris L.) genotypes was investigated under field conditions in 1981 and 1982. Each year PV, relative water content (RWC), and leaf water potential (LWP) of each cultivar at mean soil moisture tensions (MSMT) of −0.05 and −0.10 MPa were reduced significantly between 0700 hr and 1400 hr. At a MSMT of −0.05 MPa, PV and RWC of both cultivars significantly increased between 1400 hr and 1900 hr. During the same period, the LWP of ‘California Light Red Kidney’ increased to the 0700-hr level, but remained at the 1400-hr level in ‘Gloria’. At a MSMT of −0.10 MPa, PV significantly increased in ‘Gloria’ but failed to increase in ‘California Light Red Kidney’ between 1400 hr and 1900 hr. RWC remained at the 1400-hr level in both cultivars. LWP of ‘California Light Red Kidney’ remained at the 1400-hr level, but continued to decline below the 1400-hr level in ‘Gloria’ during the same period. PV declined as both RWC and LWP decreased. A relative value for the simultaneous contribution of both high ambient temperature and the water status of bean plants to loss of PV was calculated.

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Chiaravalloti, Nancy D., and John DeLuca. "The influence of cognitive dysfunction on benefit from learning and memory rehabilitation in MS: A sub-analysis of the MEMREHAB trial." Multiple Sclerosis Journal 21, no. 12 (February 6, 2015): 1575–82. http://dx.doi.org/10.1177/1352458514567726.

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Background: This study examined the influence of processing speed (PS) on benefit from treatment with the modified Story Memory Technique© (mSMT), a behavioral intervention shown to improve new learning and memory in multiple sclerosis (MS). Methods: This double-blind, placebo-controlled, randomized clinical trial included 85 participants with clinically definite MS, 45 assigned to the treatment group and 40 to the placebo-control group. Participants completed baseline and follow-up neuropsychological assessment. The present study represents a post-hoc analysis to examine the role of PS on treatment efficacy. Findings: The treatment group showed a significantly improved CVLT learning slope relative to the placebo group post-treatment, after co-varying PS performance. SDMT performance was a significant predictor of benefit from mSMT treatment, beyond group assignment. Post-hoc analysis indicated a significant correlation between the SDMT and overall cognition, indicating that the SDMT may be serving as a proxy for overall cognitive impairment. Interpretation: Performance on measures of cognitive dysfunction aside from learning and memory impact the benefit of mSMT treatment. While the current study focused on PS as a critical factor, PS may be serving as a marker for generalized cognitive dysfunction. Implications for cognitive rehabilitation in MS are discussed.© Kessler Foundation Inc. All rights reserved.

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Zou, Hua-Xi, Bai-Quan Qiu, Song-Qing Lai, Xue-Liang Zhou, Cheng-Wu Gong, Li-Jun Wang, Ming-Ming Yuan, An-Di He, Ji-Chun Liu, and Huang Huang. "Iron Metabolism and Idiopathic Pulmonary Arterial Hypertension: New Insights from Bioinformatic Analysis." BioMed Research International 2021 (October 22, 2021): 1–27. http://dx.doi.org/10.1155/2021/5669412.

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Idiopathic pulmonary arterial hypertension (IPAH) is a rare vascular disease with a poor prognosis, and the mechanism of its development remains unclear. Further molecular pathology studies may contribute to a comprehensive understanding of IPAH and provide new insights into diagnostic markers and potential therapeutic targets. Iron deficiency has been reported in 43-63% of patients with IPAH and is associated with reduced exercise capacity and higher mortality, suggesting that dysregulated iron metabolism may play an unrecognized role in influencing the development of IPAH. In this study, we explored the regulatory mechanisms of iron metabolism in IPAH by bioinformatic analysis. The molecular function of iron metabolism-related genes (IMRGs) is mainly enriched in active transmembrane transporter activity, and they mainly affect the biological process of response to oxidative stress. Ferroptosis and fluid shear stress and atherosclerosis pathways may be the critical pathways regulating iron metabolism in IPAH. We further identified 7 key genes (BCL2, GCLM, MSMO1, SLC7A11, SRXN1, TSPAN5, and TXNRD1) and 5 of the key genes (BCL2, MSMO1, SLC7A11, TSPAN5, and TXNRD1) as target genes may be regulated by 6 dysregulated miRNAs (miR-483-5p, miR-27a-3p, miR-27b-3p, miR-26b-5p, miR-199a-5p, and miR-23b-3p) in IPAH. In addition, we predicted potential IPAH drugs—celastrol and cinnamaldehyde—that target iron metabolism based on our results. These results provide insights for further definition of the role of dysregulated iron metabolism in IPAH and contribute to a deeper understanding of the molecular mechanisms and potential therapeutic targets of IPAH.

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Song, Ziling, Haiyan Xiong, Xiaoxue Meng, Qiang Ma, Yuliang Wei, Yanlu Li, Jian Liu, Mengqing Liang, and Houguo Xu. "Dietary Cholesterol Supplementation Inhibits the Steroid Biosynthesis but Does Not Affect the Cholesterol Transport in Two Marine Teleosts: A Hepatic Transcriptome Study." Aquaculture Nutrition 2023 (June 5, 2023): 1–14. http://dx.doi.org/10.1155/2023/2308669.

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Cholesterol has been used as additive in fish feeds due to the reduced use of fish meal and fish oil. In order to evaluate the effects of dietary cholesterol supplementation (D-CHO-S) on fish physiology, a liver transcriptome analysis was performed following a feeding experiment on turbot and tiger puffer with different levels of dietary cholesterol. The control diet contained 30% fish meal (0% fish oil) without cholesterol supplementation, while the treatment diet was supplemented with 1.0% cholesterol (CHO-1.0). A total of 722 and 581 differentially expressed genes (DEG) between the dietary groups were observed in turbot and tiger puffer, respectively. These DEG were primarily enriched in signaling pathways related to steroid synthesis and lipid metabolism. In general, D-CHO-S downregulated the steroid synthesis in both turbot and tiger puffer. Msmo1, lss, dhcr24, and nsdhl might play key roles in the steroid synthesis in these two fish species. Gene expressions related to cholesterol transport (npc1l1, abca1, abcg1, abcg2, abcg5, abcg8, abcb11a, and abcb11b) in the liver and intestine were also extensively investigated by qRT-PCR. However, the results suggest that D-CHO-S rarely affected the cholesterol transport in both species. The protein-protein interaction (PPI) network constructed on steroid biosynthesis-related DEG showed that in turbot, Msmo1, Lss, Nsdhl, Ebp, Hsd17b7, Fdft1, and Dhcr7 had high intermediary centrality in the dietary regulation of steroid synthesis. In conclusion, in both turbot and tiger puffer, the supplementation of dietary cholesterol inhibits the steroid metabolism but does not affect the cholesterol transport.

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Bohush, Rykhard, Sviatlana Ihnatsyeva, and Sergey Ablameyko. "Person re-identification accuracy improvement by training a CNN with the new large joint dataset and re-rank." Machine Graphics and Vision 31, no. 1/4 (December 19, 2022): 93–109. http://dx.doi.org/10.22630/mgv.2022.31.1.5.

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The paper is aimed to improve person re-identification accuracy in distributed video surveillance systems based on constructing a large joint image dataset of people for training convolutional neural networks (CNN). For this aim, an analysis of existing datasets is provided. Then, a new large joint dataset for person re-identification task is constructed that includes the existing public datasets CUHK02, CUHK03, Market, Duke, MSMT17 and PolReID. Testing for re-identification is performed for such frequently cited CNNs as ResNet-50, DenseNet121 and PCB. Re-identification accuracy is evaluated by using the main metrics Rank, mAP and mINP. The use of the new large joint dataset makes it possible to improve Rank1 mAP, mINP on all test sets. Re-ranking is used to further increase the re-identification accuracy. Presented results confirm the effectiveness of the proposed approach.

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