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Nikolic, Olivera, Sanja Stojanovic, Viktor Till, Marijana Basta-Nikolic, Kosta Petrovic, and Viktorija Vucaj-Cirilovic. "Multislice computed tomography urography in the diagnosis of urinary tract diseases." Vojnosanitetski pregled 68, no. 5 (2011): 417–22. http://dx.doi.org/10.2298/vsp1105417n.
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Background/Aim. Multislice computed tomography (MSCT) has triggered considerable changes in uroradiological imaging. The aim of this study was to establish the place of MSCT urography (MSCTU) in comparison with intravenous urography (IVU) and to determine the sensitivity and specificity of MSCT in the evaluation of urothelial abnormalities. Methods. This prospective study included 120 patients with a high clinical suspicion of urinary tract diseases divided into two groups. The group I consisted of 60 patients with macroscopic hematuria, bladder carcinoma and malignant pelvic tumors after radiotherapy or operation. They underwent both IVU and MSCTU. The group II included 60 patients (? 40 years old) with retroperitoneal and malignant pelvic tumors, complicated pyelonephritis, microscopic hematuria, acute urinary tract obstruction (without visible calculi on unenhanced scans), and they were submitted to computed tomography with additional scan phase enabling MSCTU. Results. Compared with IVU, MSCTU is more sensitive for the detection of urinary tract diseases (parenchymal changes, renal tumors, urolithiasis, fibrosis) and extraurinary processes. MSCTU is more specific than IVU for renal parenchymal abnormalities, tumors of the excretory system, urolithiasis, bladder tumors, fibrosis and extraurinary diseases. MSCTU is equally sensitive, but more specific for hydronephrosis compared to MSCT. The diagnosis made by the use of MSCTU in patients with macroscopic and microscopic hematuria and with obstruction not caused by stones, perfectly comply with operative findings and histological diagnosis. Conclusion. The obtained results support MSCTU to be the modality of choice in the diagnostic algorithm of patients with macroscopic hematuria and in the evaluation of microscopic hematuria and unexplained obstruction of the urinary tract. The only remaining role for IVU in our institution is imaging of the upper urinary tract in patients with hematuria under the age of 40.
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Wang, Sabrina, Zhengping Jia, John Roder, and Timothy H. Murphy. "AMPA Receptor-Mediated Miniature Synaptic Calcium Transients in GluR2 Null Mice." Journal of Neurophysiology 88, no. 1 (July 1, 2002): 29–40. http://dx.doi.org/10.1152/jn.2002.88.1.29.
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AMPA-type glutamate receptors are normally Ca2+ impermeable due to the expression of the GluR2 receptor subunit. By using GluR2 null mice we were able to detect miniature synaptic Ca2+ transients (MSCTs) associated with AMPA-type receptor-mediated miniature synaptic currents at single synapses in primary cortical cultures. MSCTs and associated Ca2+ transients were monitored under conditions that isolated responses mediated by AMPA or N-methyl-d-aspartate (NMDA) receptors. As expected, addition of the antagonist 6-cyano-7-nitroquinoxalene-2,3-dione (CNQX, 3 μM) blocked the AMPA receptor-mediated MSCTs. Voltage-gated Ca2+channels did not contribute to AMPA MSCTs because CdCl2 (0.1–0.2 mM) did not significantly alter the frequency or the amplitude of the MSCTs. The amplitude of AMPA MSCTs appeared to be regulated independently from event frequency since the two measures were not correlated ( R = 0.023). Synapses were identified that only expressed MSCTs attributed to either NMDA or AMPA receptors. At synapses with only NMDA responses, MSCT amplitude was significantly lower (by 40%) than synapses expressing both NMDA and AMPA responses. At synapses that showed MSCTs mediated by both AMPA and NMDA receptors, the amplitude of the transients in each condition was positively correlated ( R = 0.94). Our results suggest that when AMPA and NMDA receptors are co-expressed at synapses, mechanisms exist to ensure proportional scaling of each receptor type that are distinct from the presynaptic factors controlling the frequency of miniature release.
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Vucaj-Cirilovic, Viktorija, Milos Lucic, Kosta Petrovic, Olivera Nikolic, Mira Govorcin, and Sanja Stojanovic. "Color doppler ultrasonography and multislice computer tomography angiography in carotid plaque detection and characterization." Vojnosanitetski pregled 68, no. 5 (2011): 423–29. http://dx.doi.org/10.2298/vsp1105423v.
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Beckground/Aim. Cerebrovascular diseases are the third leading cause of mortality in the world, following malignant and cardiovascular diseases. Therefore, their timely and precise diagnostics is of great importance. The aim of this study was to compare duplex scan Color Doppler ultrasonography (CDU) with multislice computed tomography angiography (MSCTA) in detection of morphological and functional disorders at extracranial level of carotid arteries. Methods. The study included 75 patients with 150 carotid arteries examined in the period from January 2008 to April 2009. The patients were firstly examined by CDU, then MSCTA, followed by the surgery of extracranial segment of carotid arteries. In 10 patients, the obtained material was referred for histopathological (HP) examination. We used both CDU and MSCT in the analysis of: plaque surface, plaque structure, degree of stenosis, and the presence of intraplaque hemorrhage. Results. The results obtained by CDU and MSCTA were first compared between themselves, and then to intraoperative findings. Retrospective analysis showed that MSCTA is more sensitive than CDU in assessment of plaque surface (for smooth plaques CDU 89% : MSCTA 97%; for plaques with irregular surface CDU 75% : MSCTA 87%; for ulcerations CDU 54% : MSCTA 87%). Regarding determination of plaque structure (mixed plaque CDU 66% : MSCTA 70%; correlation with HP findings CDU 94% : MSCTA 96%) and localization (CDU 63% : MSCTA 65%), and in terms of sensitivity and specificity, both methods showed almost the same results. Also, there is no statistical difference between these two methods for the degree of stenosis (CDU 96% : MSCTA 98%). Conclusion. Atherosclerotic disease of extracranial part of carotid arteries primarily affects population of middle-aged and elderly, showing more associated risk factors. Sensitivity and specificity of CDU and MSCTA regarding plaque composition, the degree of stenosis and plaque localization are almost the same. These results and the fact that there are no adverse effects (high radiation dose) compared to MSCTA indicate that CDU should be the initial method in diagnostic algorythm for carotid arteries.
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Probst, C., A. Kovacs, C. Schmitz, W. Schiller, H. Schild, and A. Welz. "Quantification of Coronary Artery Stenosis with 16-Slice MSCT in Patients before CABG Surgery: Comparison to Standard Invasive Coronary Angiography." Heart Surgery Forum 8, no. 1 (February 16, 2005): 42. http://dx.doi.org/10.1532/hsf98.20041144.
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Objective: Invasive, selective coronary angiography is the gold standard for evaluation of coronary artery disease (CAD) and degree of stenosis. The purpose of this study was to compare 3-dimensional (3D) reconstructed 16-slice multislice computed tomographic (MSCT) angiography and selective coronary angiography in patients before elective coronary artery bypass graft (CABG) procedure. Methods: Sixteen-slice MSCT scans (Philips Mx8000 IDT) were performed in 50 patients (42 male/8 female; mean age, 64.44 8.66 years) scheduled for elective CABG procedure. Scans were retrospectively electrocardiogram-gated 3D reconstructed. The images of the coronary arteries were evaluated for stenosis by 2 independent radiologists. The results were compared with the coronary angiography findings using the American Heart Association segmental classification for coronary arteries. Results: Four patients (8%) were excluded for technical reasons. Thirty-eight patients (82.6%) had 3-vessel disease, 4 (8.7 %) had 2-vessel disease, and 4 (8.7%) had an isolated left anterior descending artery stenosis. In the proximal segments all stenoses >50% (56/56) were detected by MSCT; medial segment sensitivity was 97% (73/75), specificity 90.3%; distal segment sensitivity was 90.7% (59/65), specificity 77%. Conclusion: Accurate quantification of coronary stenosis greater than 50% in the proximal and medial segments is possible with high sensitivity and specificity using the new generation of 16-slice MSCTs. There is still a tendency to overestimate stenosis in the distal segments. MSCT seems to be an excellent diagnostic tool for screening patients with possible CAD.
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Vasil’ev, A. Yu, and I. S. Obelchak. "Multidetector computed tomography in the diagnosis of lesions of the main vessels for gunshot injury of the chest." Regional blood circulation and microcirculation 18, no. 1 (May 3, 2019): 31–38. http://dx.doi.org/10.24884/1682-6655-2019-18-1-31-38.
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Purpose – examine the possibilities of multislice computed tomangiography (MSCTA) in case of suspected damage to the great vessels in a chest gunshot fghting injury.Material and methods. A radiation survey of 130 wounded with gunshot injuries of the chest to assess the nature, diagnosis of gunshot injuries of the vascular bed.Results. Of the 130 wounded with gunshot wounds to the chest, 41 (31.5 %) of the injured had gunshot wounds to the chest were nonpenetrating, and 89 (68.5 %) had penetrating injuries. In 76 (58.4 %) patients with gunshot chest injuries, the nature of the wound was fragmentation, in 54 (41.6 %), wounds were bullet wounds. In the algorithm of radiation examination of patients with gunshot wounds of the chest to identify the nature of damage to the organs of the mediastinum and vascular structures, the main method of visualization was MSCT with contrast enhancement. Damage to the bone skeleton of the chest (ribs, collarbone, sternum, scapula) by MSCT was observed in 23 (17.6 %) patients. Almost half – 66 (50.1 %) of the wounded with gunshot injuries during MSCT examination, traumatic injury (pulmonitis) of the lung was observed. In 2 (1.5 %) cases, damage to the heart was detected that was not recognized at the stage of skilled surgical care. False posttraumatic aneurysm of the thoracic aorta was diagnosed in two wounded. Accuracy, sensitivity, specifcity of MSCT angiography in imaging of the vascular bed and diagnosis of damage to the great vessels of the chest cavity was 98, 97 and 97 %, respectively.Conclusions. MSCT made it possible to reliably assess the nature of the gunshot injuries of the chest, identify timely damage to the great vessels of the mediastinum, determine the localization of the foreign injuring bodies near the vascular structures, and determine the surgical tactics.
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Luo, Meimei, Run Yang, Haijie Zhang, Yi Wang, and Shengmei Gao. "Image Fusion of Multislice Spiral CT with Magnetic Resonance Imaging (MRI) in the Diagnosis and Nursing of Malignant Bone Diseases Using ANOVA." Scientific Programming 2021 (July 28, 2021): 1–7. http://dx.doi.org/10.1155/2021/4751845.
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This work aimed to analyze the diagnostic value of dynamic scanning of multislice spiral computed tomography (MSCT) and magnetic resonance imaging (MRI) for benign and malignant bone tumor and nursing intervention. 108 patients with bone tumor were selected as the research objects, all of which underwent MSCT and MRI scans. The accuracy, sensitivity, and specificity of MSCT, MRI, and MSCT + MRI for identifying benign and malignant bone tumors and nursing care were calculated, as well as the diagnostic accuracy of MSCT, MRI, and MSCT + MRI for different bone tumor pathological types. The results showed that the accuracy of MSCT + MRI (97.56%) in distinguishing benign and malignant bone lesions was remarkably higher relative to that of MSCT (85.91%) and MRI (89.85%) ( P < 0.05 ). The sensitivity and specificity of MSCT + MRI (94.85%; 90.52%) in distinguishing benign and malignant bone lesions were obviously greater in contrast to those of MSCT (83.66%; 79.05%) and MRI (86.02%; 81.17%) ( P < 0.05 ). The malignant misdiagnosis rate and malignant missing report rate of MSCT + MRI in distinguishing benign and malignant bone lesions were inferior to those of MSCT and MRI notably ( P < 0.05 ). The accuracy of MSCT + MRI in distinguishing osteosarcoma, giant-cell tumor of bone (GCT), bone cyst, and osteofibrous dysplasia (OFD) was evidently higher versus that of MSCT and MRI ( P < 0.05 ). The accuracy of MSCT + MRI in distinguishing osteofibroma and ganglioneuroma was greatly higher than that of MSCT and MRI ( P < 0.05 ). The accuracy of MSCT + MRI in distinguishing osteofibroma and ganglioneuroma was 68.64% and 71.63%, respectively. In short, in contrast to the single MSCT and MRI examination, MSCT combined with MRI detection can effectively improve the accuracy of judgment for benign and malignant bone tumor lesions and nursing care and had higher sensitivity and specificity. MSCT combined with MRI had better performance in identifying osteosarcoma, GCT, bone cyst, and OFD but poor performance in osteofibroma and ganglioneuroma.
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Galyavich, A. S., A. Y. Rafikov, and G. B. Saifullina. "Comparative analysis of echocardiography, multispiral computed tomography, myocardial perfusion scintigraphy to evaluate left ventricular volume and left ventricular ejection fraction." Kazan medical journal 94, no. 1 (February 15, 2013): 39–43. http://dx.doi.org/10.17816/kmj1767.
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Aim. To perform a comparative analysis of multislice computed tomography (MSCT), echocardiography and single photon emission computed tomography (SPECT) in the evaluation of left ventricular end-diastolic volume (LV EDV) and left ventricular ejection fraction (LVEF). Methods. The study included 44 patients (15 female, 29 male) aged of 21 to 73 years (mean age 55±11 years). LV EDV and LVEF were assessed by noninvasive MSCT coronary angiography. echocardiography and SPECT were also performed. Results. There was a statistically significant difference found between the LV EDV medians for the following pairs: MSCT vs Quantitative Gated SPECT (QGS), MSCT vs SPECT using 4D MSPECT regimen, MSCT vs echocardiography. There was no statistically significant difference determined for the following pairs: echocardiography vs SPECT, QGS SPECT vs 4D MSPECT. Difference between the LV EDV were calculated using the Bland-Altman method as following: MSCT vs echocardiography - 55±33 ml, MSCT vs QGS SPECT - 38±29 ml, MSCT vs 4D MSPECT - 30±33 ml. Differences in the LVEF evaluation methods were: MSCT vs echocardiography - 2,5±7,2%, MSCT vs QGS SPECT - 0,9±8,3%, MSCT vs 4D MSPECT - 1,2±8,1%. The highest LV EDV values were registered by MSCT, the lowest - by echocardiography, with the values registered by SPECT lying in between MSCT and echocardiography volumes. Conclusion. MSCT, echocardiography and SPECT present different left ventricular volume and similar LVEF data.
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Yeung, Winnie Wan-Yin, and Chak-Sing Lau. "Mesenchymal Stem Cell Therapy for rheumatic diseases." Hong Kong Bulletin on Rheumatic Diseases 16, no. 1 (August 1, 2016): 6–10. http://dx.doi.org/10.1515/hkbrd-2016-0002.
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AbstractMesenchymal stem cell therapy (MSCT) is an innovative treatment for rheumatic diseases. Underlying mechanism of how MSCT works in rheumatic diseases are still uncertain and with various hypotheses. Animal studies in MSCT show conflicting results mainly attributed by the differences in administration methods of MSCT, types of MSC use and randomization procedures. Human studies of MSCT are so far small scale but with satisfactory results in patients with systemic lupus erythematosus (SLE). Human studies of MSCT, however, showed less rewarding results in patients with rheumatoid arthritis (RA) and systemic sclerosis (SSc). Larger scale studies are needed to confirm the efficiency of MSCT as well as the safety profile in human use.
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Zhang, Jingni, and Yu Bao. "Value of MSCT plus MRI in the Detection of Colon Cancer." Evidence-Based Complementary and Alternative Medicine 2022 (May 31, 2022): 1–5. http://dx.doi.org/10.1155/2022/6507865.
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Colon cancer is a common digestive system malignancy with nonspecific early symptoms, which necessitates better early detection methods. The present study was conducted to assess the accuracy and clinical value of multislice spiral CT (MSCT) plus magnetic resonance imaging (MRI) for colon cancer. Between January 2019 and July 2020, 100 patients with pathologically confirmed colon cancer treated in Wuxi People’s Hospital were assessed for eligibility and recruited. All eligible patients received MRI and MSCT without any treatment prior to scanning. The accuracy of preoperative diagnosis and staging of colon cancer by MRI, MSCT, and MRI plus MSCT were analyzed using postoperative pathological results as the gold standard, and consistency analysis was performed. The receiver operating characteristic curve (ROC) was plotted, and the area under the curve (AUC) was obtained to analyze the preoperative diagnostic value. The accuracy of MRI, MSCT, and MRI plus MSCT was 98.00%, 96.00%, and 100% with good consistency (Kappa = 0.732, 0.703, and 0.756). The AUC of MRI, MSCT, and MRI plus MSCT was 0.889, 0.861, and 0.903, respectively. The preoperative diagnostic accuracy of MRI for colon cancer at T1, T2, T3, and T4 stages was 76.92%, 82.61%, 73.47%, and 86.67%, respectively, those of MSCT was 53.85%, 69.57%, 63.27%, and 40.00%, respectively, and those of MRI plus MSCT was 100.00%, 95.65%, 95.92%, and 86.67%, respectively. Consistency analysis yielded good consistency for the diagnosis of the T-staging of colon cancer (Kappa = 0.754, 0.731, 0.776). MSCT plus MRI yielded higher accuracy, specificity, and sensitivity in the detection of colon cancer versus the standalone MRI or MSCT, which demonstrated great potential in the early detection of colon cancer with a high clinical value.
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Pramitya Puteri, Nabilla, Lina Choridah, and Dwi Rochmayanti. "The use of Green Bean Juice as an Effort to Improve MSCT Image in Abdomen MSCT Protocol (in Vitro Study)." International Journal of Social Health 2, no. 9 (September 15, 2023): 564–77. http://dx.doi.org/10.58860/ijsh.v2i9.93.
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Oral contrast media usually used in abdominal MSCT examinations are water and contrast media containing iodine. However, there are advantages and disadvantages, so an alternative replacement for natural ingredients is needed, namely green bean juice. This study aims to prove that using mung bean extract can improve MSCT images for oral contrast media in the MSCT Abdomen protocol based on in vitro studies. The research method used was a quasi-experimental study to compare the extent to which mung bean extract improved MSCT images compared to water and contrast media containing iodine as oral contrast media in the Abdomen MSCT protocol based on in vitro studies. Measurement of image enhancement is done by measuring ROI. Furthermore, the measurement results were analyzed using the difference test and a follow-up test, namely the Least Significance Difference (LSD) test. The research results show that green bean juice can improve abdominal MSCT images to be used as an oral contrast medium in the Abdominal MSCT protocol based on in vitro studies. Then, there was a difference in improving the MSCT image when using green bean juice, water, and contrast media containing iodine as oral contrast media in the abdominal MSCT protocol based on in vitro studies, and it was found that there was a difference in the concentration of green bean juice in getting optimal results in the MSCT protocol. Abdomen based on in vitro studies. Conclusion Mung bean extract can be used as an oral contrast medium instead of water because it can improve MSCT images.
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Sidipratomo, Prijo, Trijono Karmawan Sukana Prija, Bachtiar Murtala, Agus Purwadianto, and Gatot Susilo Lawrence. "Role of Postmortem Multislice Computed Tomography Scan in Close Blunt Head Injury." Indonesian Biomedical Journal 6, no. 2 (August 1, 2014): 101. http://dx.doi.org/10.18585/inabj.v6i2.36.
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BACKGROUND: Conventional autopsy in Indonesia is not well accepted as it is contrary to religion and culture. New radiological imaging method such as multislice computed tomography (MSCT) scan has potential to be a diagnostic tool in forensic pathology. The purpose of this study is to determine the ability of MSCT scan in finding abnormalities in close blunt head injury compared with autopsy.METHODS: This study used descriptive qualitative method. Postmortem cases in Department of Forensic Medicine and Radiology of Dr. Cipto Mangunkusumo Hospital were selected based on inclusion criteria. Then MSCT scan and autopsy were conducted. MSCT scan and autopsy results were compared and analyzed.RESULTS: There were 491 postmortem cases of blunt head injury. However, only 10 cases fulfilled inclusion criteria. Subarachnoid haemorrhages were identified 100% with MSCT scan and 80% with autopsy. Cerebral oedemas were identified 100% either with MSCT scan and autopsy. Subdural haemorrhages were identified 100% with MSCT scan, while 50% with autopsy. Multiple fractures were identified 80% with MSCT scan, while 40% with auto.CONCLUSION: MSCT scan showed a sensitive detection in finding abnormalities in close blunt head injury. Therefore it could be as an alternative choice of examination in close blunt head injury cases.KEYWORDS: multislice computed tomography scan, postmortem, blunt head injury, autopsy
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Varlamova, Yu V., V. V. Saushkin, N. I. Ryumshina, D. S. Panfilov, B. N. Kozlov, and S. I. Sazonova. "Comparative Reproducibility Analysis of Thoracic Aorta Morphometric Parameters According to Computed Tomography and Magnetic Resonance Angiography." Journal of radiology and nuclear medicine 104, no. 3 (November 14, 2023): 192–207. http://dx.doi.org/10.20862/0042-4676-2023-104-3-192-207.
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Objective: to compare intra- and inter-operator reproducibility of thoracic aorta (ThAo) morphometric parameters, calculated by multislice computed tomography (MSCT) and magnetic resonance imaging (MRI).Material and methods. The prospective study included 20 patients with ascending aorta (AAo) dilatation (≥45 mm). All patients underwent MSCT- and MRI-angiography in electrocardiogram-gated mode. Mean diameter (Dmean) and cross-sectional area (CSA) were measured at different ThAo levels in the systole and diastole along the inner contour of the vessel. All measurements were performed by two radiologists. Each of them took measurements twice at an interval of at least 1 month. The reproducibility of repeated measurements was studied using intraclass correlation coefficient. Results. The analysis of the systolic frame revealed significant differences between the methodsfor measuring Dmean (MRI: 42.5 (41.0–47.8) mm; MSCT: 37.7 (34.7–40.3) mm; p = 0.003) and CSA at the level of the sinotubular junction (MRI: 14.8 (12.7–17.9) cm2; MSCT: 11.4 (10.3–13.3) cm2; p = 0.009), AAo CSA(MRI: 17.6 (14.6–20.8) cm2; MSCT: 19.6 (16.7–21.5) cm2; p = 0.035) and Dmean at the level proximal to left subclavian artery (LSA) (MRI: 31.5 (31.0–34.0) mm; MSCT: 31.7 (27.3–32.9) mm; p = 0.041). For the diastolic frame, significant differences between the methods were observed when measuring AAo CSA (MRI: 17.0 (14.5–19.7) cm2; MSCT: 19.7 (15.3–21.8) cm2; p = 0.025), Dmean (MRI: 30.5 (29.3–32.8) mm; MSCT: 29.8 (27.1–31.3) mm; p = 0.05) and CSA at the level proximal to LSA (MRI: 7.5 (6.9–7.9) cm2; MSCT: 7.4 (5.9–7.8) cm2; p = 0.007), as well as CSA at the left atrium level (MRI: 4.9 (4.2–5.0) cm2; MSCT: 5.1 (4.67–5.5) cm2; p = 0.042). For MSCT-angiography, good intra- and inter-operator reproducibility of measurements at all ThAo levels was obtained. For MRI-angiography, there was a strong intra- and interoperator variability in determining Dmean and CSA at the levels of aortic arch and descending aorta.Conclusion. Aortic cross-sectional area showed the best intra- and inter-operator reproducibility and comparability of measurements between MSCT- and MRI-angiography
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Körner, M., M. Krötz, K. G. Kanz, K. J. Pfeifer, M. Reiser, and U. Linsenmaier. "Development of an accelerated MSCT protocol (Triage MSCT) for mass casualty incidents: comparison to MSCT for single-trauma patients." Emergency Radiology 12, no. 5 (May 30, 2006): 203–9. http://dx.doi.org/10.1007/s10140-006-0485-9.
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Uebelacker, Roman, Simon S. Martin, Mariuca Vasa-Nicotera, and Silvia Mas-Peiro. "Value of Post-/Pre-Procedural Aortic Regurgitation Ratio vs. Pre-Procedural Aortic Valve Calcium Score to Predict Moderate to Severe Paravalvular Leak Requiring Post-Dilation after Transcatheter Aortic Valve Implantation." Journal of Clinical Medicine 12, no. 24 (December 17, 2023): 7735. http://dx.doi.org/10.3390/jcm12247735.
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Background and aim: Tools that assist interventionists in selecting patients for post-dilation (PD) are needed. We aimed to assess whether pre-interventional aortic valve calcium (AVC) or the peri-interventional aortic regurgitation (ARI) ratio is a better predictor for a more than mild paravalvular leak (PVL) requiring PD after TAVI. Methods: Patients undergoing TAVI with available data on AVC derived from MSCTs and the ARI ratio derived from peri-interventional hemodynamic curves were studied. The main outcome was moderate-to-severe PVL requiring PD. Results: In 237 patients, more than mild PVL after valve deployment was present in 25.7%. PD was performed in 65 patients. The median (IQR) total AVC was 390.5 (211.5–665.4) mm3. All calcification values were significantly higher in patients who underwent PD. The median (IQR) individual threshold was 600 (550–685) Hus. The overall ARI ratio was 0.78 (0.61–0.96), with values being significantly lower in patients who underwent PD: 0.61 (0.49–0.80) vs. 0.82 (0.69–0.99) (p < 0.001). Both the ARI ratio (OR [95%CI] 0.053 [0.014–0.203]; p < 0.001) and AVC (1.01 [1.000–1.002]; p = 0.015) predicted PD need. ROC curves showed higher discrimination for the ARI ratio (AUC 0.73) than for any calcification parameter (all AUCs ≤ 0.62). Conclusions: The ARI ratio provides interventionists with a powerful predictive tool for PVL requiring PD after TAVI that is beyond the predictive value of pre-procedural valve calcification derived from MSCT.
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Liu, Zhixue, Xiaoyan Zhang, and Lihong Ma. "Analysis of correlation between MSCT classification and prognosis of basal ganglia hypertensive intracerebral hemorrhage." Discussion of Clinical Cases 6, no. 4 (May 25, 2020): 1. http://dx.doi.org/10.5430/dcc.v6n4p1.
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Objective: To investigate the correlation between MSCT grading and the prognosis of basal ganglia hypertensive intracerebral hemorrhage.Methods: A total of 86 patients with basal ganglia hypertensive cerebral hemorrhage admitted to our hospital from May 2017 to March 2018 were selected. The clinical data and imaging data were collected from 86 patients. The MSCT images were observed and summarized by two radiologists. Based on the morphology of cisterna ambiens and brain stem, the correlation of MSCT grading to Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) grading was analyzed by use of Spearman correlation analysis.Results: Among 86 patients, the number of MSCT grade I, II, III and IV were 29 cases, 38 cases, 9 cases and 10 cases respectively. There was no significant correlation between MSCT grading and age, sex as well as types of combined underlying diseases in the patients with basal ganglia hypertensive intracerebral hemorrhage (p > .05). Spearman correlation analysis showed that there was a positive correlation between MSCT grading and GCS score of basal ganglia hypertensive intracerebral hemorrhage. The higher MSCT grade was, the higher GCS score was (r = .719, p < .001). There was a positive correlation between MSCT grading and GOS grading of basal ganglia hypertensive intracerebral hemorrhage. The higher MSCT grade was, the higher GOS grade was, leading to a poor prognosis (r = .734, p < .001). 86 cases of basal ganglia hypertensive intracerebral hemorrhage showed round or quasi-circular high-density shadows in MSCT images, the CT value ranged from 50 Hu to 80 Hu. Low-density bands surrounded the hematoma in the acute stage, and space-occupying effect could be seen in some patients, which resulted in the compression of ventricular sulcus and cistern and the displacement of midline structure. Subacute basal ganglia hypertensive intracerebral hemorrhage patients showed a relative decrease in the density of hematoma, with the extent of edema gradually reduced, the focus showed a high-density shadow in the center; chronic basal ganglia hypertensive intracerebral hemorrhage focus showed a cystic low-density shadow.Conclusion: MSCT grading of basal ganglia hypertensive intracerebral hemorrhage is positively correlated to GCS and GOS grading. MSCT grading can contribute to the prognostic evaluation to the patients.
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Malhotra, Rajneesh, Manisha Mishra, Poonam Khurana, Monika Aggarwal, Yugal Mishra, Zile Singh Meharwal, Vijay Kohli, et al. "Three-Dimensional Reconstruction of Ultrafast 16-Slice Computed Tomography Images and CT Angiography versus Conventional Coronary Angiography at One Year in Multivessel Coronary Artery Bypass Surgery." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 1, no. 2 (December 2005): 92–95. http://dx.doi.org/10.1097/01243895-200500120-00008.
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Background The aim of this study was to evaluate and compare the postoperative graft patency assessment by multislice spiral computed tomography (MSCT) scan and conventional coronary angiography (CCA) in coronary artery bypass grafting (CABG) patients 1 year after surgery. Methods Sixty-nine patients who underwent isolated CABG at least 1 year before the study, were subjected to both MSCT angiography with cardiac gating and CCA. The results were evaluated and compared. Results There were 209 grafts in 69 patients. All grafts were evaluated by both MSCT angiography and CCA. Seventy-eight grafts were on the anterior wall, 83 on the lateral wall and 48 on the inferior wall of the heart. On MSCT angiography, all left internal mammary arteries were visualized with 3-dimensional reconstruction and found to be patent. Of 209 grafts, 11 grafts (5.26%) were blocked, 6 grafts on the lateral wall and 5 on the inferior wall. All patent grafts were correctly evaluated by MSCT angiography (specificity 100%). However, 2 grafts that were found to be patent on MSCT angiography were blocked on CCA (MSCT sensitivity 81.8%). Conclusions Postoperative evaluation of coronary bypass grafts is possible with very good resolution by MSCT angiography. This method allows evaluation of the bypass grafts and the quality of anastomosis with a noninvasive method that is comparable with CCA.
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Yang, Bin, Zhonghua Gan, Shulan Liu, Mingxia Li, Guangyan Si, and Qizhou He. "Value of multi-slice spiral computerized tomography for diagnosis of synchronous colorectal carcinoma: a retrospective study." Journal of International Medical Research 50, no. 1 (January 2022): 030006052210760. http://dx.doi.org/10.1177/03000605221076060.
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Objective To compare the accuracy of multi-slice spiral computerized tomography (MSCT) with colonoscopy for diagnosing synchronous colorectal carcinoma (SCC). Methods We retrospectively analyzed all consecutive patients admitted to our institution with colorectal carcinoma between 19 September 2014 and 31 January 2020. Data on SCC patients who had undergone MSCT and colonoscopy were analyzed. Information on tumor location, tumor size, missed diagnosis by MSCT or colonoscopy, T stage, pathological type, and reasons for missed diagnosis was recorded and used to assess the diagnostic accuracies of MSCT and colonoscopy. Results Twenty-three cases met the inclusion criteria. MSCT plus colonoscopy had a significantly higher diagnostic accuracy (93.5%) than colonoscopy alone. There were significant differences in missed diagnosis rates of proximal cancer (34.8%) and distal cancer (4.3%) by colonoscopy. For MSCT, the missed diagnosis rate for tumors with a median long diameter of 1.25 cm (interquartile range 0.80, 1.50) was significantly lower than that for larger tumors (long diameter 4.00 cm; 3.00, 6.00). Conclusions MSCT is a valuable diagnostic tool for SCC that can effectively minimize the missed diagnosis rate of primary tumors when combined with colonoscopy.
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Eriksen, Erlend, Omeed Neghabat, Terje H. Larsen, Sahrai Saeed, and Øyvind Bleie. "Long-term multimodality imaging follow-up of ST-segment elevation myocardial infarction patients treated with bioresorbable vascular scaffold: advantages and challenges." Coronary Artery Disease 34, no. 6 (May 8, 2023): 415–24. http://dx.doi.org/10.1097/mca.0000000000001249.
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Background: Multislice computed tomography (MSCT) offers a non-invasive method of imaging bioresorbable scaffolds (BRS). Objectives: To investigate the advantages and challenges using MSCT in the follow-up after BRS implantation. Method: The BRS cohort consisting of 31 patients in the ‘BRS in STEMI’ trial was examined by multimodality imaging and followed long-term. Minimum lumen area (MLA) and average lumen area (ALA) were examined 12 and 36 months after BRS implantation with MSCT. Optical coherence tomography (OCT) at 12 months was used as a reference. Results: Measured by MSCT, the mean MLA was 0.05 ± 1.32 mm² (P = 0.85), but ALA was 1.32 (±2.59 mm², P = 0.015) greater than by OCT. ALA and MLA did not change significantly from 12 to 36 months. MSCT identified all cases of restenosis but missed one patient with massive malapposition. Conclusion: Our data support using MSCT in the follow-up after BRS implantation. Invasive investigation should still be considered for patients with unexplained symptoms.
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He, Xiao, Yi Yang, Mengwei Yao, Lei Yang, Luoquan Ao, Xueting Hu, Zhan Li, et al. "Combination of human umbilical cord mesenchymal stem (stromal) cell transplantation with IFN-γ treatment synergistically improves the clinical outcomes of patients with rheumatoid arthritis." Annals of the Rheumatic Diseases 79, no. 10 (June 19, 2020): 1298–304. http://dx.doi.org/10.1136/annrheumdis-2020-217798.
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ObjectivesTo clarify the key role of circulating interferon-γ (IFN-γ) and to improve the clinical efficacy of mesenchymal stem cell (MSC) transplantation (MSCT) in patients with rheumatoid arthritis (RA).MethodsStudy of wild-type or IFN-γR-/- MSCT was first evaluated in a murine model of collagen-induced arthritis (CIA) following which a phase 1/2 randomised controlled study was conducted in 63 patients with RA who responded poorly to regular clinical treatments. Subjects were randomly assigned to an MSCT monotherapy group (n=32) or an MSCT plus recombinant human IFN-γ treatment group (n=31), with 1 year of follow-up. The primary end points consisted of efficacy as assessed as good or moderate EULAR response rates and the proportion of patients at 3 months attaining American College of Rheumatology 20 (ACR20) response rates.ResultsIn the murine studies, wild-type MSCT significantly improved the clinical severity of CIA, while IFN-γR-/- MSCT aggravated synovitis, and joint and cartilage damage. Transitioning from the murine to the clinical study, the 3-month follow-up results showed that the efficacy and ACR20 response rates were attained in 53.3% patients with MSCT monotherapy and in 93.3% patients with MSCT combined with IFN-γ treatment (p<0.05). No new or unexpected safety issues were encountered in 1-year follow-up for either treatment group.ConclusionsThe results of this study show that IFN-γ is a key factor in determining the efficacy of MSCT in the treatment of RA, and that an MSC plus IFN-γ combination therapeutic strategy can greatly improve the clinical efficacy of MSC-based therapy in RA patients.
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Khoroshun, E. M., V. V. Makarov, V. V. Nehoduiko, O. V. Yasinskyi, O. P. Sharmazanova, and S. A. Pulyaev. "Oblique projections in the analysis of multislice computed tomography data in gunshot wounds." EMERGENCY MEDICINE 20, no. 3 (May 17, 2024): 211–16. http://dx.doi.org/10.22141/2224-0586.20.3.2024.1694.
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Background. The purpose is to determine the place and role of oblique projections in the analysis of multislice computed tomography (MSCT) data in gunshot wounds. Materials and methods. More than 3,300 MSCT studies performed in wounded and traumatized patients over a certain period in the Military Medical Clinical Center of the Northern Region of the Medical Forces Command were prospectively studied. All the wounded were male, the average age was 42.1 ± 2.4 years. MSCT of the head, thoracic and abdominal organs, pelvis, and limbs was performed. The frequency of using oblique projections and their informativeness were studied. Results. A prospective study demonstrated that coronal, axial, sagittal projections, and 3D modeling were used in 100 % of cases, and in 21.4 % — oblique projections to improve MSCT results. The distribution by localization of MSCT was as follows: head — 32.9 %, neck — 7.6 %, chest organs — 32.2 %, abdominal organs — 22.3 %, limbs — 5.0 %. MSCT in angiomode was performed in 3.5 % of injured and traumatized patients: head — 27.2 %, neck — 18.4 %, chest organs — 28.9 %, abdominal organs — 23.7 %, limbs — 1.8 %. Oblique projections in MSCT data analysis were used when studying the wound channel in 82.3 % of cases, to improve the visualization of vessels during MSCT in angiomode — in 12.6 % and to improve the visualization of bone fracture lines — in 5.1 %. Conclusions. In the structure of MSCT studies, the head, thoracic organs, abdominal organs, neck, and limbs prevail by localization (in descending order). Oblique projections are used is 1/5 of cases and allow to improve the visualization of the direction of the wound channel, vessels during angiography and lines of flat and long tubular bone fractures.
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Wildberger, J. E., T. Leiner, and A. H. Mahnken. "MSCT bei thorakalen Notfällen." Der Radiologe 49, no. 6 (June 2009): 492–500. http://dx.doi.org/10.1007/s00117-008-1806-7.
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Linsenmaier, U., and M. Reiser. "MSCT in der Notfalldiagnostik." Der Radiologe 49, no. 6 (June 2009): 479–80. http://dx.doi.org/10.1007/s00117-009-1887-y.
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Liu, Yuanhang, Huanju Li, Yong-Le Qiu, Kun-Shan Li, Yueting Lu, and Wenjing Wang. "Nanoscale biomimetic nano system for the co-delivery of SNS032 and tumor necrosis factor related apoptosis inducing ligand to enhance therapeutic efficacy in oral squamous cell carcinoma cell line SCC25." Materials Express 11, no. 8 (August 1, 2021): 1321–30. http://dx.doi.org/10.1166/mex.2021.2055.
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Tumor necrosis factor related apoptosis inducing ligand (TRAIL) has been used extensively as an anticancer agent in vitro and clinical trials. However, due to poor pharmacokinetics and drug resistance, TRAIL only exert limited therapeutic effects on malignant tumor. SNS032 is a new and effective selective CDK inhibitor. SNS032 and TRAIL transfected MSC (MSCT) derived extracellular vesicles (MSCT-EXO) can both inhibit RNA synthesis and induce apoptosis of cancer cells. Previous studies have shown that SNS032 and TRAIL have a synergistic effect in the treatment of cancer. Objective: Construct a biomimetic nano system for synergistically deliver SNS032 and TRAIL to induce apoptosis of SCC25 cells. Methods: SNS032 loaded gelatin nanoparticles (G-SNS032) were prepared by single coacervation method, SNS032/TRAIL gelatin biomimetic exosomes cocarrier (MSCT-EXO/G-SNS032) were isolated and purified by ultracentrifugation and filtration. The expression of specific proteins was detected by BCA method to confirm the source of EXO. The in vitro release curve was drawn by a validated liquid chromatography tandem mass spectrometry assay. This study examines the antitumor effects at molecular and cellular levels in response to MSCT-EXO/G-SNS032 treatment in vitro. Results: MSCT-EXO/G-SNS032 granules were round and well dispersed with a diameter of 187±23 nm. At the same time, it has high drug loading and good release profile. SNS032, G-SNS032 and MSCT-EXO inhibited growth of SCC25 tumor cells with dose dependence manner. MSCT-EXO + SNS032 and MSCT-EXO + GSNS032 showed a satisfactory synergistic action in the ratio range of 200:1-20:1 (Combination index, CI < 1). At the ratio of 2000:1 to 20:1, the synergistic effect of MSCT-EXO/G-SNS032 was preferable to MSCT-EXO+GSNS032 group (P <0.05). MSCT-EXO/G-SNS032 could inhibit the expression of JAKs/STAT signaling pathway as well as the expression of related anti-apoptotic proteins, regulate p53 signaling pathway and its downstream pathway simultaneously. Conclusion: SNS032/TRAIL delivered by gelatin biomimetic exosomes, show a high inhibitory effect on oral squamous cell carcinoma cells though multiple signaling pathways, over which provides a new idea for the treatment of multidrug-resistant tumors.
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Dehdashti, Amir R., Stefano Binaghi, Antoine Uske, and Luca Regli. "Comparison of multislice computerized tomography angiography and digital subtraction angiography in the postoperative evaluation of patients with clipped aneurysms." Journal of Neurosurgery 104, no. 3 (March 2006): 395–403. http://dx.doi.org/10.3171/jns.2006.104.3.395.
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Object In this study the accuracy of multislice computerized tomography (MSCT) angiography in the postoperative examination of clip-occluded intracranial aneurysms was compared with that of intraarterial digital subtraction (DS) angiography Methods Forty-nine consecutive patients with 60 clipped aneurysms (41 of which had ruptured) were studied with the aid of postoperative MSCT and DS angiography. Both types of radiological studies were reviewed independently by two observers to assess the quality of the images, the artifacts left by the clips, the completeness of aneurysm occlusion, the patency of the parent vessel, and the duration and cost of the examination. The quality of MSCT angiography was good in 42 patients (86%). Poor-quality MSCT angiograms (14%) were a result of the late acquisition of images in three patients and the presence of clip or motion artifacts in four. Occlusion of the aneurysm on good-quality MSCT angiograms was confirmed in all but two patients in whom a small (2-mm) remnant was confirmed on DS angiograms. In one patient, occlusion of a parent vessel was seen on DS angiograms but missed on MSCT angiograms. The sensitivity and specificity for detecting neck remnants on MSCT angiography were both 100%, and the sensitivity and specificity for evaluating vessel patency were 80 and 100%, respectively (95% confidence interval 29.2–100%). Interobserver agreements were 0.765 and 0.86, respectively. The mean duration of the examination was 13 minutes for MSCT angiography and 75 minutes for DS angiography (p < 0.05). Multislice CT angiography was highly cost effective (p < 0.01). Conclusions Current-generation MSCT angiography is an accurate noninvasive tool used for assessment of clipped aneurysms in the anterior circulation. Its high sensitivity and low cost warrant its use for postoperative routine control examinations following clip placement on an aneurysm. Digital subtraction angiography must be performed if the interpretation of MSCT angiograms is doubtful or if the aneurysm is located in the posterior circulation.
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Zhu, Guan Qun, Seung Hwan Jeon, Woong Jin Bae, Sae Woong Choi, Hyun Cheol Jeong, Kang Sup Kim, Su Jin Kim, et al. "Efficient Promotion of Autophagy and Angiogenesis Using Mesenchymal Stem Cell Therapy Enhanced by the Low-Energy Shock Waves in the Treatment of Erectile Dysfunction." Stem Cells International 2018 (August 29, 2018): 1–14. http://dx.doi.org/10.1155/2018/1302672.
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Background. Mesenchymal stem cell therapy (MSCT) and defocused low-energy shock wave therapy (ESWT) has been shown to ameliorate erectile dysfunction (ED). However, the interactions and effects of action between MSCT and ESWT remain poorly understood. In this study, we investigated the mechanisms of combination therapy with MSCT and ESWT in a rat model of diabetic ED. Materials and Methods. Eight-week-old male Sprague-Dawley rats were randomly divided into 2 parts. Diabetic rats induced by streptozotocin (65 mg/kg) were randomly divided into 4 groups: (1) DM control group, (2) DM + ESWT group, (3) DM + MSCT group, and (4) DM + ESWT + MSCT group. The sham group was a normal control group (without streptozotocin). MSCT and (or) ESWT were, respectively, administered to each group according to the proposal for 8 weeks. Immediately after recording of intracavernous pressure (ICP), the penis was then harvested for histologic analysis, ELISA, and Western blotting. Results. The ratio of ICP/MAP was significantly higher in the DM + ESWT + MSCT group than in ESWT or MSCT treated group (P<0.05). Also, the treatment stimulated angiogenesis and vasodilatation in the corpus cavernosum (P<0.05). ESWT increased the quantity of MSCs in the corpus cavernosum and also induced MSCs to express more VEGF in vitro and vivo (P<0.05) which activated the PI3K/AKT/mTOR and NO/cGMP signaling pathways in the corpus cavernosum. The combination approach stimulated autophagy and decreased apoptosis in the corpus cavernosum. NGF and BDNF expressions were higher in the DM + ESWT + MSCT group than in the DM control group (P<0.01). Furthermore, the treatment promoted the MSC recruitment by inducing penile tissues to express more PECAM and SDF-1. Conclusions. Combination of LI-ESWT and MSCT can get a better result than a single treatment by expressing more VEGF which can take part in autophagy by triggering the PI3K/AKT/mTOR signaling pathway. This cooperative therapy would provide a new research direction in ED treatment for the future.
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Zhao, Zhiwei, Yong Zhou, Meng Jiang, and Ling Dang. "Application Value of MRI Combined with MSCT in Diagnosis and Staging of Colon Carcinoma." Computational and Mathematical Methods in Medicine 2022 (May 23, 2022): 1–6. http://dx.doi.org/10.1155/2022/2593844.
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Objective. To clarify the application value of magnetic resonance imaging (MRI) combined with multislice spiral computed tomography (MSCT) in the diagnosis and staging of colon carcinoma (CC). Methods. A total of 103 patients with histopathologically diagnosed CC were enrolled. Patient clinical and imaging data were collected, and MRI and MSCT images were analyzed to assess the accuracy of MRI, MSCT, and their combination in diagnosing tumor (T) staging of CC. Results. Among the 103 cases of histopathologically diagnosed CC, 26 cases (25.24) were in stage T1-2, 72 cases (69.90) were in stage T3, and 5 cases (4.85) were in stage T4. The accuracy of MRI in diagnosing stage T1-2, T3, and T4 was 80.77%, 88.89%, and 60.00%, respectively, with an average of 76.55%. The accuracy rates of MSCT in diagnosing T1-2, T3, and T4 stages were 73.08%, 90.27%, and 60.00%, respectively, with an average of 74.45%. The accuracy rates of MRI+MSCT in diagnosing T1-2, T3, and T4 were 88.46%, 95.83%, and 80.00%, respectively, with an average of 88.10%. Conclusions. Compared with single use of MRI or MSCT, MRI+MSCT provides accurate imaging data with higher accuracy, which is more helpful for the T-staging evaluation of CC.
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Mahnken, A. H., J. E. Wildberger, A. M. Sinha, K. Dedden, S. Stanzel, R. Hoffmann, T. Schmitz-Rode, and R. W. Günther. "Value of 3D-volume rendering in the assessment of coronary arteries with retrospectively ECG-gated multislice spiral CT." Acta Radiologica 44, no. 3 (May 2003): 302–9. http://dx.doi.org/10.1080/j.1600-0455.2003.00057.x.
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Purpose: To assess the diagnostic value and measurement precision of 3D volume rendering technique (3D-VRT) from retrospectively ECG-gated multislice spiral CT (MSCT) data sets for imaging of the coronary arteries. Material and Methods: In 35 patients, retrospectively ECG-gated MSCT of the heart using a four detector row MSCT scanner with a standardized examination protocol was performed as well as quantitative X-ray coronary angiography (QCA). The MSCT data was assessed on segmental basis using 3D-VRT exclusively. The coronary artery diameters were measured at the origin of each main coronary branch and 1 cm, 3 cm and 5 cm distally. The minimum, maximum and mean diameters were determined from MSCT angiography and compared to QCA. Results: A total of 353 of 525 (67.2%) coronary artery segments were assessable by MSCT angiography. The proximal segments were more often assessable when compared to the distal segments. Stenoses were detected with a sensitivity of 82.6% and a specificity of 92.8%. According to the Bland-Altmanmethod the mean differences between QCA and MSCT ranged from −0.55 to 1.07 mm with limits of agreement from −2.2 mm to −2.7 mm. Conclusion: When compared to QCA, the ability of 3D-VRT to quantitatively assess coronary artery diameters and coronary artery stenoses is insufficient for clinical purposes.
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Jiang, Min, Xiaoxiao Wang, Xiuhong Shan, Donggang Pan, Yingjun Jia, Enzhen Ni, Yuan Hu, and Hao Huang. "Value of multi-slice spiral computed tomography in the diagnosis of metastatic lymph nodes and N-stage of gastric cancer." Journal of International Medical Research 47, no. 1 (December 2, 2018): 281–92. http://dx.doi.org/10.1177/0300060518800611.
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Objective To establish new diagnostic criteria for improvement of the accuracy of multi-slice spiral computed tomography (MSCT) in diagnosing the N-stage and lymph node (LN) metastasis of gastric cancer (GC). Methods MSCT was performed with plain and triphasic dynamic contrast enhancement. Different regions of LN metastasis and N-staging were determined according to the herein-proposed combined diagnostic criteria and were then correlated with the pathological analysis. The Kappa consistency test was used to study the accuracy of MSCT. Results The accuracy of MSCT in diagnosing the N-stage as a whole was 86.3%, and that in diagnosing LN metastasis was 79.1% to 98.9%. The Kappa values for stages N0, N1, and N3 ranged from 0.449 to 0.662, indicating good consistency in diagnosing these three stages between MSCT and the postsurgical pathological results. The Ktotal value was 0.567 between MSCT and the postsurgical pathological results in diagnosing LN metastasis. The risk of LN metastasis increased with the progression of lesion infiltrates. Conclusions Application of the combined diagnostic criteria increased the diagnostic performance of MSCT in not only judging the N-stage but also diagnosing LN metastasis. This study will provide valuable reference data for surgical planning for patients with GC in the clinical setting.
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Wei, Dan, JiaLi Hou, Ke Zheng, Xin Jin, Qi Xie, Lamei Cheng, and Xuan Sun. "Suicide Gene Therapy Against Malignant Gliomas by the Local Delivery of Genetically Engineered Umbilical Cord Mesenchymal Stem Cells as Cellular Vehicles." Current Gene Therapy 19, no. 5 (December 27, 2019): 330–41. http://dx.doi.org/10.2174/1566523219666191028103703.
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Background: Glioblastoma (GBM) is a malignant tumor that is difficult to eliminate, and new therapies are thus strongly desired. Mesenchymal stem cells (MSCs) have the ability to locate to injured tissues, inflammation sites and tumors and are thus good candidates for carrying antitumor genes for the treatment of tumors. Treating GBM with MSCs that have been transduced with the herpes simplex virus thymidine kinase (HSV-TK) gene has brought significant advances because MSCs can exert a bystander effect on tumor cells upon treatment with the prodrug ganciclovir (GCV). Objective: In this study, we aimed to determine whether HSV-TK-expressing umbilical cord mesenchymal stem cells (MSCTKs) together with prodrug GCV treatment could exert a bystander killing effect on GBM. Methods and Results: Compared with MSCTK: U87 ratio at 1:10,1:100 and 1:100, GCV concentration at 2.5µM or 250µM, when MSCTKs were cocultured with U87 cells at a ratio of 1:1, 25 µM GCV exerted a more stable killing effect. Higher amounts of MSCTKs cocultured with U87 cells were correlated with a better bystander effect exerted by the MSCTK/GCV system. We built U87-driven subcutaneous tumor models and brain intracranial tumor models to evaluate the efficiency of the MSCTK/GCV system on subcutaneous and intracranial tumors and found that MSCTK/GCV was effective in both models. The ratio of MSCTKs and tumor cells played a critical role in this therapeutic effect, with a higher MSCTK/U87 ratio exerting a better effect. Conclusion: This research suggested that the MSCTK/GCV system exerts a strong bystander effect on GBM tumor cells, and this system may be a promising assistant method for GBM postoperative therapy.
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Wang, Weiping, Simei Niu, Xiangfu Meng, and Youjie Li. "Study on Sensitivity and Accuracy of Diagnosis of Intracranial Aneurysms Based on 256-Slice Spiral CT Angiography." Journal of Medical Imaging and Health Informatics 10, no. 4 (April 1, 2020): 967–73. http://dx.doi.org/10.1166/jmihi.2020.2962.
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Objective: To investigate the value of 256-slice spiral CT angiography in the diagnosis and postoperative evaluation of patients with intracranial aneurysms. Methods: A total of 62 patients with intracranial aneurysms diagnosed by neurosurgery in our hospital were randomly collected from 2017.03–2018.11. The MSCTA was performed by labeling intravenous non-ionic contrast agent (iodosyls alcohol). The obtained image was imageprocessed at Sun's stand-alone workstation (Philip256iCT). Observe the position, shape, size of the aneurysm, the relationship between the neck and the artery and the structure of the skull base, and compare with the intraoperative findings to understand the anastomosis between the preoperative and intraoperative. Postoperatively, 28 cases were reviewed, and the surgical results, the patency of the arterial artery, and the presence or absence of aneurysm residual were confirmed. Results: Sixty-two patients with intracranial aneurysms were diagnosed with MSCTA and DSA. A total of 66 aneurysms and multiple aneurysms were found. Of these, 32 patients underwent direct operative MSCTA and 43 underwent craniotomy. Endovascular interventional therapy. The location, shape, size, relationship between the neck and the parental artery of the aneurysm and the DSA performance were basically consistent with MSCTA. No false positive results were found. Postoperative examination of MSCTA in 28 cases, all developed well, the arterial artery was well patency, no residual aneurysm was seen. Conclusion: MSCTA can accurately display the location, shape and size of the aneurysm, the relationship between the neck and the artery and the structure of the skull base. It can be used as an important tool for clinical diagnosis and treatment of aneurysm imaging. An important method for post-review and follow-up.
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Wintermark, Max, Antoine Uske, Marc Chalaron, Luca Regli, Philippe Maeder, Reto Meuli, Pierre Schnyder, and Stefano Binaghi. "Multislice computerized tomography angiography in the evaluation of intracranial aneurysms: a comparison with intraarterial digital subtraction angiography." Journal of Neurosurgery 98, no. 4 (April 2003): 828–36. http://dx.doi.org/10.3171/jns.2003.98.4.0828.
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Object. The goal of this study was to assess the diagnostic accuracy of computerized tomography (CT) angiography performed with the aid of multislice technology (MSCT angiography) in the investigation of intracranial aneurysms, by comparing this method with intraarterial digital subtraction (IADS) angiography. Methods. Fifty consecutive adult patients, who successively underwent MSCT angiography (four rows) and IADS angiography of intracranial vessels, were prospectively identified. The MSCT angiography studies consisted of 1.25-mm slices, with 0.8-mm reconstruction intervals, a pitch of 0.75, and timing determined by a test bolus. Two neuroradiologists, who were blinded to the initial interpretation of the MSCT angiograms as well as to those of the IADS angiograms, independently reviewed the MSCT angiograms for the detection and characterization of intracranial aneurysms. Forty-nine intracranial aneurysms were identified in 40 patients; 33 of these lesions were responsible for subarachnoid hemorrhage. The sensitivity, specificity, and accuracy of MSCT angiography in the detection of intracranial aneurysms were 94.8, 95.2, and 94.9%, respectively, on a per-aneurysm basis and 99, 95.2, and 98.3%, respectively, on a per-patient basis. Interobserver agreement was 98%. There was an excellent correlation between aneurysm size assessed using MSCT angiography and that determined by IADS angiography (slope = 0.916, r = 0.877, p < 0.001); however, 2 mm stood as the cutoff size below which the sensitivity of MSCT angiography was statistically lower. That method displayed great accuracy in characterizing the morphological characteristics of the aneurysm. Conclusions. Multislice CT angiography is an accurate and robust noninvasive screening test for intracranial aneurysms. It performs better than that reported for single-slice CT angiography. Introduction of eight- and especially 16-row MSCT angiography will provide further progression through thinner slices, a lower pitch, and a purely arterial phase.
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Čanaki, Franciska, and Krešimir Dolić. "Radiation protection in MSCT diagnostics." Radiološki vjesnik 47, no. 2 (October 10, 2023): 45–51. http://dx.doi.org/10.55378/rv.47.2.6.
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Sustavni pregled literature na temu „Zaštita od zračenja kod MSCT pretraga“ analizira prihvaćene i ustaljene, a naglašava moderne metode zaštite od zračenja u području višeslojne kompjutorizirane tomografije (multislice computed tomography, MSCT). Cilj rada je upoznati čitatelja o osnovnim pojmovima vezanim uz zaštitu od zračenja, biološkom utjecaju ionizirajućeg zračenja isporučenog tijekom MSCT pretrage na ljudski organizam i mjerenju njegovih razina, parametrima koji utječu na smanjenje (ili nepravilnim korištenjem, povećanje) doze zračenja te načinima kako se pravilnom adaptacijom tih parametara može značajno utjecati na ozračenost pacijenta tijekom MSCT pregleda te sažeti najvažnije spoznaje glede optimizacije zaštite od zračenja i različite tehnike njenog postizanja. Zdravstvenim radnicima koji sudjeluju u provođenju postupaka MSCT dijagnostike ovaj rad može služiti kao podsjetnik temeljnih pojmova i važnosti savjesnog provođenja mjera zaštite od zračenja u svakodnevnoj praksi.
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Sukhova, M. B., and T. N. Trofimova. "Modern aspects of MSCT diagnostics of acute massive pulmonary embolism." Diagnostic radiology and radiotherapy 12, no. 4 (January 19, 2022): 7–14. http://dx.doi.org/10.22328/2079-5343-2021-12-4-7-14.
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Introduction: The growing importance of the MSCT method in the case of acute massive pulmonary embolism forms new diagnostic directions — the determination of objective MSCT markers of right ventricular dysfunction and the search for new, previously ignored, MSCT parameters of angiographic severity of embolic load.The purpose of the study: to evaluate the prognostic role and predictivity of the results of MSCT angiopulmonography in the case of choosing a surgical method for the treatment of pulmonary embolism.Research objectives. Тo analyze the influence of the volume of preserved peripheral arterial pulmonary blood flow on the results of surgical treatment of acute massive PE and the dependence of the average pressure in the pulmonary artery on the MSCT parameters.Materials and methods: this work examines the surgical approach to the treatment and possibilities of preoperative MSCT diagnosis of acute massive pulmonary embolism. The 7-year analysis included the analysis of more than 1,200 MSCT studies for acute massive pulmonary embolism. 147 patients were selected for surgical treatment and successfully operated on, the remaining patients received conservative therapy with dynamic MSCT observation. According to international classifiers, the analysis of classes and categories of intraoperative and postoperative complications of emergency surgical treatment was performed in comparison with the initial MSCT parameters of acute massive PE.Results. The smaller the number of segmental branches of the pulmonary artery is determined at the preoperative stage, the higher the risks of mortality and complications of emergency surgical treatment of acute massive PE (p<0,001). A direct relationship between the average pressure in the pulmonary artery and the MSCT parameter-the diameter of the unpaired vein (p<0,001) was confirmed. An increase in the number of visualized bronchial arteries corresponds to an increase in the average pressure in the pulmonary artery (p<0,05).Discussion. The lightning speed of the course of pulmonary embolism dictates an exceptional approach to the completeness of the diagnosis of the disease, and the change in treatment tactics due to the increasing demand for surgical methods of treatment changes the diagnostic approach to acute pulmonary embolism in general. The success of surgical treatment of PE directly depends on the completeness and speed of preoperative MSCT diagnostics, in particular, on the quality of analysis of intra-pulmonary and intracardiac hemodynamics.Conclusion: For acute massive PE with obstruction at the level of the trunk and / or main branches of the pulmonary artery, with a sharp and often uncontrolled progression of right ventricular failure, risk stratification in «real time» becomes the most relevant, the time factor becomes of paramount importance for determining treatment tactics. The inclusion of previously ignored MSCT parameters in the algorithm of preoperative diagnosis allows us to modify the algorithm of preoperative diagnosis, to form and introduce the concept of the reference MSCT status of a patient with acute massive PE.
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Wang, Junling, Xia Li, Zhijie Zhang, Chao Jing, and Jie Li. "Clinical Research of Combined Application of DCEUS and Dynamic Contrast-Enhanced MSCT in Preoperative cT Staging of Gastric Cancer." Journal of Oncology 2021 (October 19, 2021): 1–7. http://dx.doi.org/10.1155/2021/9868585.
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Purpose. To investigate the clinical value of double contrast-enhanced ultrasound (DCEUS) combined with dynamic contrast-enhanced multislice CT (MSCT) in preoperative T staging of gastric cancer (GC). Methods. 206 patients with GC confirmed by preoperative gastroscopy from February 2019 to February 2021 were collected, all patients were examined by DCEUS and dynamic contrast-enhanced MSCT before operation, and the invasion depth (T staging) of GC was evaluated. The diagnosis results of DCEUS, dynamic contrast-enhanced MSCT, and combined diagnosis of DCEUS and MSCT methods (D&M method) were compared with the pathological staging results (gold standard). Results. The correct diagnosis rate of MSCT was 27.27% in T1 staging, 55.56% in T2 staging, 42.11% in T3 staging, 59.29% in T4 staging, and 55.34% in summation. The correct diagnosis rate of DCEUS was 90.91% in T1 staging, 88.89% in T2 staging, 78.95% in T3 staging, 82.86% in T4 staging, and 83.98% in summation. The correct diagnosis rate of the D&M method was 100.00% in T1 staging, 94.44% in T2 staging, 89.47% in T3 staging, 93.57% in T4 staging, and 93.69% in summation. The D&M method had higher correct diagnosis rate than MSCT or DCEUS alone, the correct diagnosis rate of the D&M method in T1, T2, T3, and T4 staging was significantly higher than that of MSCT ( P < 0.05 ). The correct diagnosis rate of the D&M method in T1, T3, and T4 was significantly higher than that of DCEUS ( P < 0.05 ). The Youden index of preoperative T1, T2, T3, and T4 staging of GC by the D&M method was 99.49%, 94.44%, 84.13%, and 90.54%, respectively, and the Kappa values of these were 0.954, 0.966, 0.707, and 0.881, respectively. Conclusions. Dynamic contrast-enhanced MSCT combined with DCEUS in the diagnosis of preoperative cT staging of GC has more validity, reliability, and revenue than the using of MSCT or DCEUS alone, which is an image evaluation method worthy of clinical promotion.
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Latief, Adhitya, Pradono Suhardi, and Cholid Badri. "THREE-DIMENSIONAL MODEL PRINTING IN ORAL AND MAXILLOFACIAL RECONSTRUCTIVE SURGERY: COMPARISON OF THREE-DIMENSIONAL MODELS AND MULTISLICE COMPUTED TOMOGRAPHY SCANS." International Journal of Applied Pharmaceutics 9 (January 1, 2018): 74. http://dx.doi.org/10.22159/ijap.2017.v9s2.18.
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Objective: The objective of this study is to compare fabrication of commonly used three-dimensional (3D) models with original multislice computed tomography (MSCT) scan data for accuracy and precision in reconstruction surgery.Methods: MSCT data from 10 samples are processed and manufactured to be 3D models. Both groups are then measured and analyzed for the purpose of comparison.Results: The average mandibular measurement difference between 3D models and MSCT scans is 0.26 mm more <2%. The final results of the comparison reveal high accuracy in 3D models compared to MSCT scan data.Conclusion: The 3D model could be considered as surgical guidance for maxillofacial reconstruction surgery since it yields highly accurate results.
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Malik, Ricat Hinaywan, Winarto Winarto, Selamat Budijitno, Udadi Sadhana, and Yan Wisnu Prajoko. "RELATIONSHIP BETWEEN FAMILY HISTORY, BLOODY STOOL, PALPABLE MASS, ANEMIA, AND MSCT ABDOMEN AND KOLON CARSINOMA Cross-Sectional Study at Dr.Kariadi General Hospital in 2016." Sains Medika : Jurnal Kedokteran dan Kesehatan 9, no. 1 (November 11, 2018): 24. http://dx.doi.org/10.30659/sainsmed.v9i1.2264.
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Background: Colon cancer, a colorectal cancer, is the third most common epithelial malignancy in the world. Family history, bloody stool, palpable mass, anemia, and abdominal MSCT are symptoms and signs of colon carcinoma.Objective: To determine the relationship between the 5 variables and the incidence of colon carcinoma at Dr. Kariadi Hospital, Semarang in 2016.Methods: a Cross-sectional observational analytical study using medical record (RM) and complementary primary data. The inclusion criteria werethe complete medical record, and clinical diagnosis of suspected colon carcinoma. Data obtained from the department of Anatomy Pathology/PA (11,794PA results) were traced to the medical record section (46 patients with suspected colon carcinoma). The incomplete data were confirmed by: contacting the patient/family, obtaining the archive in the laboratory and radiology resulting in 27 patients meeting the inclusion criteria. Analysis was done using chi-square test, Spearman-Kendall bivariate correlation, and logistic regression.Results: Abdominal MSCT was moderately associated with colon carcinoma (p = 0.003; r = 0.488), while family history, bloody stool, palpable mass, and anemia were not associated with colon cancer. Analysis between predictors of outcome: Bloody stool was moderately associated with anemia (p = 0.006; r = 0.411), and anemia was weakly associated MSCT (p = 0.035; r = 0.351). Abdominal MSCT was the predictive factor for colon carcinoma (p = 0.021).Conclusion: Abdominal MSCT was found to be associated with the incidence of colon carcinoma. Bloody stool was associated with anemia, and anemia was associated with abdominal MSCT. MSCT was the predictive factor for colon cancer.
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Nirma, Nirmala, Ni Putu Rita Jeniyanthi, and Cokorda Istri Arywidiastuti. "ANALISIS ANALISIS PENGARUH VARIASI SLICE THICKNESS TERHADAP KUALITAS CITRA DAN INFORMASI ANATOMI PEMERIKSAAN MSCT SCAN THORAX PADA KASUS EMPHYSEMA DI RSD MANGUSADA BADUNG." Jurnal Ilmiah Kedokteran dan Kesehatan 2, no. 1 (November 21, 2022): 01–12. http://dx.doi.org/10.55606/klinik.v2i1.738.
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One of the clinical features that can be found in Thorax is emphysema. Emphysema is one of the pathological processes of the lung parenchyma in COPD (Chronic Obstructive Pulmonary Disease). The patient must inhale and exhale with a larger volume of air in order to meet the metabolic needs of oxygen distribution (O2), removal of carbon dioxide (CO2) and maintaining acid-base balance. MSCT has an important role in diagnosing emphysema. One of the biggest drivers for technical improvement in MSCT is image quality. MSCT Scan image quality is influenced by several factors, namely spatial resolution, resolution contrast, noise, and artifacts. One of the parameters that affect image quality is the selection of slice thickness. Slice thickness is the thickness of the slice or slice of the object being examined. Thorax MSCT scan is routinely performed using a slice thickness of 1.25 – 5 mm. Thorax examination in cases of emphysema used a slice thickness of 0.5 mm – 1.5 m.This type of research is quantitative with an experimental approach. This study was conducted by analyzing the effect of slice thickness variations on image quality and anatomical information of MSCT Scan Thorax in cases of Emphysema. Based on the results of the Friedman test overall, it shows that there is an influence of image quality and anatomical information on the MSCT Scan Thorax examination in cases of emphysema using slice thickness variations of 1.5mm, 3mm and 4.5mm on spatial resolution, contrast resolution, and noise. Based on the results of this study, the researcher can recommend the MSCT Scan Thorax examination in cases of emphysema using a slice thickness of 1.5mm with the aim that the results of image quality and anatomical information on the MSCT Scan Thorax examination in cases of emphysema look clear and good.
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Jaiganesh, B., and R. Ramachandran. "Handoff Management Using MSCTP AND MIP." i-manager’s Journal on Wireless Communication Networks 2, no. 1 (June 15, 2013): 23–30. http://dx.doi.org/10.26634/jwcn.2.1.2308.
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Bosoni, Carlo, Michele Pietragalla, Davide Maraghelli, Vieri Rastrelli, Luca Giovanni Locatello, Isacco Desideri, Veronica Giuntini, Lorenzo Franchi, and Cosimo Nardi. "Is Panoramic Radiography Really a Key Examination before Chemo-Radiotherapy Treatment for Oropharyngeal Cancer?" Applied Sciences 11, no. 17 (August 28, 2021): 7965. http://dx.doi.org/10.3390/app11177965.
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Aim: To evaluate the diagnostic accuracy of panoramic radiography (PAN) for the identification of infectious foci of the tooth and periradicular bone before definitive chemo-radiotherapy treatment for oropharyngeal cancer, using multislice spiral computed tomography (MSCT) imaging as the reference standard. Materials and methods: 50 patients with oropharyngeal cancer who had performed both pre-treatment MSCT and PAN were retrospectively evaluated. Pre-radiotherapy MSCT showed 65 deep caries, 37 root remnants, 143 stage III periodontal diseases, and 77 apical periodontitis, for a total of 322 infectious foci. The same number of healthy teeth (control group) was selected via MSCT to be analysed by PAN. Sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy for PAN images with respect to MSCT imaging were examined. Results: PAN showed sensitivity, negative predictive value, and diagnostic accuracy of 100% for deep caries, root remnants, and stage III periodontal disease, whereas there were 46.8%, 64.7%, and 72.1% apical periodontitis respectively. Conclusions: PAN did not show great diagnostic accuracy in the assessment of apical periodontitis, and therefore maxillofacial MSCT carried out before chemo-radiotherapy treatment should always be examined to identify dental and jaw diseases. Deep caries, root remnants, and stage III periodontal disease were perfectly detected on PAN.
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Nikitin, P. A., N. V. Nudnov, I. A. Znamenskiy, R. Kh Azimov, A. A. Karpova, and E. E. Averin. "Multi-Slice Computed Tomography in Assessing Mesh Titanium Implant Shrinkage After Prosthetic Inguinal Hernioplasty." Journal of radiology and nuclear medicine 102, no. 6 (February 3, 2022): 377–82. http://dx.doi.org/10.20862/0042-4676-2021-102-6-377-382.
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Objective: to assess the percentage of mesh “titanium silk” implant shrinkage after inguinal hernia repair surgery in the late postoperative period using multi-slice computed tomography (MSCT). Material and methods. The comparative assessment of the long-term results of treatment in 90 patients with inguinal hernias was performed using MSCT. In 36 (40%) patients of Group 1 the titanium implant was used in Lichtenstein hernia repair surgery. In Group 2, 54 (60%) patients were operated by laparoscopic hernia repair surgery. On day 3 and 3 months after surgery every patient underwent MSCT with subsequent determination of the implant square. Results. The percent of mesh “titanium silk” implant shrinkage 3 months after surgery according to MSCT was 4.4% in Lichtenstein hernia repair group, and 8.3% in laparoscopic hernia repair group. According to Kruskal-Wallis test, there were no statistic differences of this indicator between two groups (p = 0,185). Conclusion. The analysis of long-term results of inguinal hernia repair surgery with titanium mesh implants using MSCT showed that implant square significantly decreases 3 months after surgery. There were no significant differences in implants shrinkage regarding the type of surgery. MSCT is an effective method for evaluating the size of mesh titanium implants after hernia repair surgery.
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Cao, Yantian, Bangjie Zhang, Rong Lin, Qingzhi Wang, Jie Wang, and Fangfang Shen. "Mesenchymal Stem Cell Transplantation for Liver Cell Failure: A New Direction and Option." Gastroenterology Research and Practice 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/9231710.
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Background and Aims. Mesenchymal stem cell transplantation (MSCT) became available with liver failure (LF), while the advantages of MSCs remain controversial. We aimed to assess clinical advantages of MSCT in patients with LF. Methods. Clinical researches reporting MSCT in LF patients were searched and included. Results. Nine articles (n=476) related with LF patients were enrolled. After MSCT, alanine aminotransferase (ALT) baseline decreased largely at half a month (P<0.05); total bilirubin (TBIL) baseline declined to a certain stable level of 78.57 μmol/L at 2 and 3 months (P<0.05). Notably, the decreased value (D value) of Model for End-Stage Liver Disease score (MELD) of acute-on-chronic liver failure (ACLF) group was higher than that of chronic liver failure (CLF) group (14.93 ± 1.24 versus 4.6 ± 5.66, P<0.05). Moreover, MELD baseline of ≥20 group was a higher D value of MELD than MELD baseline of <20 group with a significant statistical difference after MSCT (P=0.003). Conclusion. The early assessment of the efficacy of MSCT could be based on variations of ALT at half a month and TBIL at 2 and 3 months. And it had beneficial effects for patients with LF, especially in ACLF based on the D value of MELD.
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Ainiyah, Nur, Sigit Wijokongko, and Nanang Sulaksono. "PERANAN ADAPTIVE ITERATIVE DOSE REDUCTION 3D (AIDR 3D) DALAM MENINGKATKAN KUALITAS CITRA MSCT ABDOMEN." JRI (Jurnal Radiografer Indonesia) 4, no. 1 (May 10, 2021): 25–34. http://dx.doi.org/10.55451/jri.v4i1.82.
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Background: Abdominal MSCT has better sensitivity and specificity, however its radiation exposure is high. Adaptive Iterative Dose Reduction (AIDR) 3D is an iterative reconstruction technology on Toshiba which produces a better image quality by reducing noise and streak artifacts in low dose. Based on author’s observation, abdominal MSCT performed at the hospital uses a standard routine abdominal MSCT protocol without adjusting the level of AIDR 3D. AIDR 3D has several strength level allowing an optimal image quality. This study was aimed to explain the role of AIDR 3D in improving the image quality and radiation dose of abdominal MSCT.
Methods: This research method is descriptive with the literature study approach, by collecting articles from ProQuest, Google Scholar, PubMed, SpringerLink, and ScienceDirect about the role of AIDR 3D on abdominal MSCT published 2013-2020. The articles were selected according to the inclusion criteria. So there were 4 relevant journals which were then analyzed by making a journal summary, evaluating, giving opinions so that conclusions and suggestions can be drawn.
Result: The results showed that AIDR 3D can improve the image quality of abdominal MSCT by reducing noise, artifacts and increasing CNR, SNR, image sharpness. Noise reduction and CNR increase, the most prominent SNR is found in AIDR 3D Strong, followed by Standard and Mild. AIDR 3D can reduce radiation doses better without reducing image quality
Conclusion: AIDR 3D can improve image quality on abdominal MSCT and the use of integrated AIDR 3D SUREExposore 3D can reduce radiation doses better without reducing image quality. Reduction of radiation dose between 23% to 76%.
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Malhotra, Rajneesh, Manisha Mishra, Poonam Khurana, Yugal Mishra, Zile S. Meharwal, Vijay Kohli, Ramesh Bapna, Ravi R. Kasliwal, and Naresh Trehan. "Coronary Artery Bypass Grafts Assessment at One Year by Noninvasive Multislice Computed Tomography and Invasive Coronary Angiography." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 2, no. 3 (May 2007): 116–20. http://dx.doi.org/10.1097/imi.0b013e318065b0f6.
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Objective The aim of this study was to evaluate and compare the postoperative graft patency by multislice computed tomography (MSCT) and invasive coronary angiography (ICA) in patients with multivessel coronary artery bypass grafting at 1 year of surgery. Methods Patients (n = 114) who underwent isolated coronary artery bypass grafting at least 1 year (1.4 ± 0.4 years) previously were subjected to both 16-slice CT angiography with cardiac gating and ICA, and their results were evaluated and compared. All patients were receiving β-blockers; mean heart rate was 64 ± 6 beats/min. Results The mean age of the patients was 59.7 ± 8.5 years. There was a total of 338 grafts (113 internal mammary artery grafts, 8 radial artery grafts, and 217 saphenous venous grafts). On MSCT angiography, all the left internal mammary arteries were visualized with 3D reconstruction. All internal mammary arteries were found to be patent. Twenty-one grafts were occluded or stenosed (21/338, 6.25%). One occluded graft was on the anterior wall (1/20, 0.83%), 11 occluded grafts were on the lateral wall of the heart (11/128, 8.59%), and 9 occluded grafts were on the inferior wall of the heart (9/90, 10.0%); MSCT resulted in no false-positive diagnosis of stenosis (specificity, 100%). However, 2 grafts that were found to be patent on MSCT angiography were blocked on ICA (MSCT sensitivity, 96.3%). Conclusions Postoperative assessment of coronary bypass grafts is possible with an excellent resolution by MSCT angiography. Patency of bypass grafts can be checked by MSCT angiography, and the assessment is comparable with ICA.
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Yatskevich, N. V., E. Gurbanova, G. L. Gurevich, and E. M. Skryagina. "Evaluation of Safety of 9and 6-Week Treatment Regimens in Patients with Rifampicin-Resistant Tuberculosis in the Republic of Belarus." Tuberculosis and Lung Diseases 102, no. 1 (March 20, 2024): 34–39. http://dx.doi.org/10.58838/2075-1230-2024-102-1-34-39.
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The objective: to evaluate the safety of 39and 24-week treatment regimens in the patients with rifampicin-resistant tuberculosis (RR-TB).Subjects and Methods. Cohorts of patients with RR-TB were treated with the following regimens: 550 patients received modified short course treatment regimens (mSCT), and 139 patients were treated with BPaLM regimen. Serious adverse events (SAEs) and adverse events of special interest (AESI) of grade 3 or higher were assessed according to the EndTB Severity Grading Scale, Version 5.Results. In mSCT cohort, 113 SAEs were reported, in BPaLM cohort, 12 SAEs were reported, at least 1 SAE was reported in 16.0% and 7.2% of patients, respectively. In mSCT cohort, 37 AESI were reported in 5.8% of patients. Of the 150 SAEs/AESI reported in mSCT cohort, 78.7% have resolved, 4.0% are being resolved, 0.7% have resolved with sequelae, and 2.7% have not resolved. Of the 12 SAEs in BPaLM cohort, 66.7% have resolved, 16.7% are being resolved, and 8.3% have resolved with sequelae. Drugs were discontinued in 16.8% of SAEs, 8.1% of AESI in mSCT cohort, and 25.0% of SAEs in BPaLM cohort. In mSCT cohort, 21 patients died during treatment, only in 6 patients the influence of anti-tuberculosis drugs on the fatal outcome could not be ruled out, in 15 cases there was no such a correlation. In BPaLM cohort, 1 patient died due to progression of concomitant cancer.Conclusions. SAEs/AESI rarely occur with mSCT and BPaLM regimens and rarely lead to treatment discontinuation. Appropriate monitoring and management of SAEs/AESI is an important component of clinical practice.
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von Tengg-Kobligk, Hendrik, Dittmar Böckler, Tania M. Jose, Marika Ganten, Osos Kotelis, Simon Nagel, Frederik L. Giesel, et al. "Feeding Arteries of the Spinal Cord at CT Angiography before and after Thoracic Aortic Endografting." Journal of Endovascular Therapy 14, no. 5 (October 2007): 639–49. http://dx.doi.org/10.1177/152660280701400507.
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Purpose: To study the visualization of spinal cord feeding arteries in patients with complex thoracic aortic pathology undergoing endovascular aortic repair (EVAR) using an optimized protocol for multislice computed tomographic angiography (MSCTA). Methods: Eighteen consecutive patients (13 men; mean age 63 years, range 45–79) with aortic type B dissections (n=5), chronic expanding aortic dissections (n=5), thoracic aortic aneurysms (n=6), or penetrating aortic ulcers (n=2) underwent 16-slice CTA before and after (mean interval 9 days) EVAR. Pulse rate and neurological status were documented. Quantitative density measurements were taken at regions of interest (ROI) in the ascending thoracic aorta and at the level of the diaphragm. Two experienced radiologists qualitatively assessed the posterior intercostal arteries (PIA; fully visible, partially visible, non-visible), dorsal branches (DB; visible/non-visible), and artery of Adamkiewicz (AKA; visible/non-visible) on multiplanar reformations and maximum intensity projection reconstructions. Results: MSCTA was performed successfully in 17/18 patients before and after EVAR (1 patient was excluded after EVAR owing to rising creatinine levels). Before EVAR, MSCTA revealed 197/203 PIAs within the stented area, of which 179 were fully and 18 partially visible. No significant (p=0.37) difference was noted for overall PIA detection within the stented area on post-EVAR MSCTA (185/203 PIA), although only 124 were fully and 61 partially visible. Similar results were obtained for DB visualization. The AKA were seen in 10/17 patients pre EVAR and 9/17 post EVAR. In 2 patients, the AKA was localized within the stented aortic segment. ROI analysis revealed contrast densities of 427±89 HU and 398±84 HU on pre- and post-EVAR MSCTA, respectively. No neurological events were observed. Conclusion: The majority of posterior intercostal arteries and dorsal branches remain open after EVAR due to retrograde perfusion. High-resolution MSCTA permits accurate pre-and post-EVAR visualization of spinal cord feeding arteries in patients with thoracic aortic pathology.
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Wehrschuetz, M., E. Wehrschuetz, H. Schuchlenz, and G. Schaffler. "Accuracy of MSCT Coronary Angiography with 64 Row CT Scanner—Facing the Facts." Clinical Medicine Insights: Cardiology 4 (January 2010): CMC.S3864. http://dx.doi.org/10.4137/cmc.s3864.
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Improvements in multislice computed tomography (MSCT) angiography of the coronary vessels have enabled the minimally invasive detection of coronary artery stenoses, while quantitative coronary angiography (QCA) is the accepted reference standard for evaluation thereof. Sixteen-slice MSCT showed promising diagnostic accuracy in detecting coronary artery stenoses haemodynamically and the subsequent introduction of 64-slice scanners promised excellent and fast results for coronary artery studies. This prompted us to evaluate the diagnostic accuracy, sensitivity, specificity, and the negative und positive predictive value of 64-slice MSCT in the detection of haemodynamically significant coronary artery stenoses. Thirty-seven consecutive subjects with suspected coronary artery disease were evaluated with MSCT angiography and the results compared with QCA. All vessels were considered for the assessment of significant coronary artery stenosis (diameter reduction ≥ 50%). Thirteen patients (35%) were identified as having significant coronary artery stenoses on QCA with 6.3% (35/555) affected segments. None of the coronary segments were excluded from analysis. Overall sensitivity for classifying stenoses of 64-slice MSCT was 69%, specificity was 92%, positive predictive value was 38% and negative predictive value was 98%. The interobserver variability for detection of significant lesions had a κ-value of 0.43. Sixty-four-slice MSCT offers the diagnostic potential to detect coronary artery disease, to quantify haemodynamically significant coronary artery stenoses and to avoid unnecessary invasive coronary artery examinations.
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Yu, Chuanwen, and Chuang Sun. "Diagnostic Value of Multislice Spiral Computed Tomography Combined with Serum AFP, TSGF, and GP73 Assay in the Diagnosis of Primary Liver Cancer." Evidence-Based Complementary and Alternative Medicine 2022 (June 7, 2022): 1–5. http://dx.doi.org/10.1155/2022/6581127.
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Objective. To explore the diagnostic value of multislice spiral computed tomography (MSCT) scan combined with serum alpha-fetoprotein (AFP), tumor-specific growth factor (TSGF), and Golgi protein73 (GP73) assays in the diagnosis of primary liver cancer (PLC). Methods. Totally, 60 patients with PLC admitted to The Second Hospital of Dalian Medical University from January 2019 to January 2020 were included in group A, 60 patients with liver cirrhosis were included in group B, and 60 healthy subjects were included in group C. The serum AFP, TSGF, and GP73 levels were determined, and all participants received MSCT scanning. The diagnostic efficacy of MSCT, assays of serum AFP, TSGF, and GP73, and their combined detection was analyzed. Results. Group A had the highest levels of AFP, TSGF, and GP73, followed by group B, and then group C. The sensitivity, specificity, positive predictive value, and negative predictive value of MSCT for PLC were 80.0%,91.7%, 82.8%, and 90.2%, respectively, while those of combined detection of MSCT plus serum AFP, TSGF, and GP73 for PLC were 100.0%, 93.3%, 88.2%, and 100.0%. The combined detection was associated with significantly a higher detection rate of PLC versus stand-alone detection. Conclusion. MSCT plus serum AFP, TSGF, and GP73 has a higher detection rate versus stand-alone detection, which shows great potential in the diagnosis of PLC.
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Beatović, Slobodanka, Miloš Veljković, Isidora Grozdić-Milojević, Jelena Petrović, Strahinja Odalović, Milica Stojiljković, Vera Artiko, and Dragana Šobić-Šaranović. "The significance of 18-fluoro-deoxyglucose positron emission tomography with computed tomography in comparison with multi-slice computed tomography in recurrent bladder cancer." Medicinska istrazivanja 56, no. 3 (2023): 51–57. http://dx.doi.org/10.5937/medi56-44169.
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Introduction: Positron emission tomography with computed tomography using 18-fluoro-deoxyglucose (18FDG-PET/CT) is still not applied routinely in clinical practice for the evaluation of recurrent bladder cancer. Recent guidelines recognize the importance of 18FDG-PET/CT, but multi-slice computed tomography (MSCT) is still recommended for monitoring these patients. Aim: To determine the agreement between 18FDG-PET/CT and MSCT findings in the categorization of patients into N and M stages of the disease and the agreement of two diagnostic modalities regarding the number of detected lesions. Material and methods: 31 patients (22 men and 9 women), mean age 61.2 ± 9.2 years, were included in our study after surgical treatment and histopathological confirmation of bladder cancer. Zones of pathological uptake of 18FDG were interpreted visually and semi-quantitatively using the maximum standardized uptake value (SUVmax). The agreement of 18FDG-PET/ CT findings was compared to previous MSCT using Cohen's kappa test for interobserver agreement, interpreted based on the Altman's criteria. Results: The overall agreement between 18FDG-PET/CT and MSCT in N stage of the disease was 77% (c = 0.54; moderate agreement); in stage N0 68%, N2 77%, N3 29%. In M stage, total agreement was 53% (c = 0.10; poor agreement); in stage M0 39%, M1a 22%, M1b 44%. 18FDG-PET/CT detected a total of 29 lesions in N stage of the disease, while MSCT detected 16 lesions, with the agreement of 71% (c = 0.41; moderate agreement). In the M stage of the disease, 18FDG-PET/CT detected 42 lesions and MSCT detected 30 lesions, with overall agreement of 52% (c = 0.07; poor agreement). Conclusion: Our results show that there is a moderate agreement between 18FDG-PET/CT and MSCT findings in the categorization of patients and the number of detected lesions in N stage of disease, but that 18FDG-PET/CT detects more lesions. 18FDG-PET/CT also detects a higher number of lesions in M stage, but the agreement with MSCT findings is poor.
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Shin, H. "Neue Entwicklungen in der MSCT." Radiologie up2date 10, no. 04 (December 2010): 351–64. http://dx.doi.org/10.1055/s-0030-1255900.
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Caixeta, Adriano, Philippe Généreux, Maria Eduarda M. de Siqueira, Antonio Baruzzi, Alexandre Abizaid, and Gregg W. Stone. "MSCT Identification of Vulnerable Plaque." JACC: Cardiovascular Imaging 9, no. 2 (February 2016): 207–9. http://dx.doi.org/10.1016/j.jcmg.2015.01.027.
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