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Author: Grafiati

Published: 10 December 2022

Last updated: 29 January 2023

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1

Rull, A., R. Beltrán-Debón, G. Aragonès, F. Rodríguez, C. Alonso-Villaverde, J. Camps, and J. Joven. "MS131 THE EXPRESSION OF CYTOKINE GENES IN THE AORTA INFLUENCED BY DIET: THE EFFECT OF MCP-1 DEFICIENCY." Atherosclerosis Supplements 11, no. 2 (June 2010): 136. http://dx.doi.org/10.1016/s1567-5688(10)70632-2.

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2

YAMASHITA, Masahiro, Akiko KOBAYASHI, Yoshiki OHGO, Mikio NAKAMURA, Saburo NEYA, and Daisuke HASHIZUME. "MS31." Nihon Kessho Gakkaishi 51, no. 1 (2009): 59–64. http://dx.doi.org/10.5940/jcrsj.51.59.

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3

Kaye, Kenneth M., Kenneth M. Izumi, Hong Li, Eric Johannsen, David Davidson, Richard Longnecker, and Elliott Kieff. "An Epstein-Barr Virus That Expresses Only the First 231 LMP1 Amino Acids Efficiently Initiates Primary B-Lymphocyte Growth Transformation." Journal of Virology 73, no. 12 (December 1, 1999): 10525–30. http://dx.doi.org/10.1128/jvi.73.12.10525-10530.1999.

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ABSTRACT An Epstein-Barr virus (EBV) recombinant (MS231) that expresses the first 231 amino acids (aa) of LMP1 and is truncated 155 aa before the carboxyl terminus transformed resting B lymphocytes into lymphoblastoid cell lines (LCLs) only when the infected cells were grown on fibroblast feeder cells (K. M. Kaye et al., J. Virol. 69:675–683, 1995). Higher-titer MS231 virus has now been compared to wild-type (WT) EBV recombinants for the ability to cause resting primary B-lymphocyte transformation. Unexpectedly, MS231 is as potent as WT EBV recombinants in causing infected B lymphocytes to proliferate in culture for up to 5 weeks. When more than one transforming event is initiated in a microwell, the MS231 recombinant supports efficient long-term LCL outgrowth and fibroblast feeder cells are not required. However, with limited virus input, MS231-infected cells differed in their growth from WT virus-infected cells as early as 6 weeks after infection. In contrast to WT virus-infected cells, most MS231-infected cells could not be grown into long-term LCLs. Thus, the LMP1 amino-terminal 231 aa are sufficient for initial growth transformation but the carboxyl-terminal 155 aa are necessary for efficient long-term outgrowth. Despite the absence of the carboxyl-terminal 155 aa, MS231- and WT-transformed LCLs are similar in latent EBV gene expression, in ICAM-1 and CD23 expression, and in NF-κB and c-jun N-terminal kinase activation. MS231 recombinant-infected LCLs, however, require 16- to 64-fold higher cell density than WT-infected LCLs for regrowth after limiting dilution. These data indicate that the LMP1 carboxyl-terminal 155 aa are important for growth at lower cell density and appear to reduce dependence on paracrine growth factors.

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4

Wan Mohd Tajuddin, Wan Nur Baitty, Faridah Abas, Iekhsan Othman, and Rakesh Naidu. "Molecular Mechanisms of Antiproliferative and Apoptosis Activity by 1,5-Bis(4-Hydroxy-3-Methoxyphenyl)1,4-Pentadiene-3-one (MS13) on Human Non-Small Cell Lung Cancer Cells." International Journal of Molecular Sciences 22, no. 14 (July 10, 2021): 7424. http://dx.doi.org/10.3390/ijms22147424.

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Diarylpentanoid (DAP), an analog that was structurally modified from a naturally occurring curcumin, has shown to enhance anticancer efficacy compared to its parent compound in various cancers. This study aims to determine the cytotoxicity, antiproliferative, and apoptotic activity of diarylpentanoid MS13 on two subtypes of non-small cell lung cancer (NSCLC) cells: squamous cell carcinoma (NCI-H520) and adenocarcinoma (NCI-H23). Gene expression analysis was performed using Nanostring PanCancer Pathways Panel to determine significant signaling pathways and targeted genes in these treated cells. Cytotoxicity screening revealed that MS13 exhibited greater inhibitory effect in NCI-H520 and NCI-H23 cells compared to curcumin. MS13 induced anti-proliferative activity in both cells in a dose- and time-dependent manner. Morphological analysis revealed that a significant number of MS13-treated cells exhibited apoptosis. A significant increase in caspase-3 activity and decrease in Bcl-2 protein concentration was noted in both MS13-treated cells in a time- and dose-dependent manner. A total of 77 and 47 differential expressed genes (DEGs) were regulated in MS13 treated-NCI-H520 and NCI-H23 cells, respectively. Among the DEGs, 22 were mutually expressed in both NCI-H520 and NCI-H23 cells in response to MS13 treatment. The top DEGs modulated by MS13 in NCI-H520—DUSP4, CDKN1A, GADD45G, NGFR, and EPHA2—and NCI-H23 cells—HGF, MET, COL5A2, MCM7, and GNG4—were highly associated with PI3K, cell cycle-apoptosis, and MAPK signaling pathways. In conclusion, MS13 may induce antiproliferation and apoptosis activity in squamous cell carcinoma and adenocarcinoma of NSCLC cells by modulating DEGs associated with PI3K-AKT, cell cycle-apoptosis, and MAPK pathways. Therefore, our present findings could provide an insight into the anticancer activity of MS13 and merits further investigation as a potential anticancer agent for NSCLC cancer therapy.

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5

Миронов, А. А., А. А. Ушанов, and А. А. Чернова. "Evaluation of the combining ability of black radish (Raphanus sativus L.) lines." Kartofel` i ovoshi, no. 3 (March 10, 2022): 37–40. http://dx.doi.org/10.25630/pav.2022.11.57.007.

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Цель исследования – оценка комбинационной способности линий редьки черной по основным хозяйственно ценным признакам. Исследования проводили в 2019–2020 годах на базе ООО «Селекционная станция имени Н.Н. Тимофеева», подразделении ФГБОУ ВО РГАУ – МСХА имени К.А. Тимирязева, которая располагается на территории Москвы. Почвы опытного поля – среднесуглинистые дерново-подзолистые на покровном суглинке. Материалом служили линии редьки черной из коллекции ООО «Селекционная станция имени Н.Н. Тимофеева»: стерильные линии: МS 26, MS151 и фертильные линии: Рч65, Рч62, Рч64, Рч61, РчРын. Стандартом выбран популярный сорт редьки Зимняя круглая черная. Оценку комбинационной способности проводили методом скрещивания двух групп генотипов. Расчет комбинационной способности производили по первой математической модели, предложенной В.К. Савченко. Агроклиматические показатели 2019 и 2020 годов в целом несущественно отличались от среднемноголетних значений и были оптимальны для выращивания редьки. Опыты закладывали рендомизированным методом. Схема посева 20×50, однострочная, по 30 растений в варианте, в двукратной повторности. Уход за растениями – общепринятый. Оценку гибридных комбинаций проводили по следующим параметрам: масса корнеплода, масса листьев, диаметр и длина корнеплода, урожайность, индекс формы корнеплода. 5 октября 2020 года шесть гибридных комбинаций были заложены на хранение до 10 апреля 2021 года. Гибридную комбинацию MS26 × Рч65, обладающую комплексом ценных хозяйственных признаков (высокая урожайность, средняя масса листьев, округлая форма корнеплода), можно рекомендовать для станционного сортоиспытания. Наилучшая сохранность отмечена у гибридных комбинаций MS151 × Рч65 и MS151 × Рын (87,38 и 85,80% соответственно). Анализ эффектов ОКС выявил селекционную ценность линий MS151 и Рын (большая масса корнеплода), Рч61 (большая масса листьев), MS26, MS151 и Рч62 (округлая форма корнеплода). Гибридные комбинации MS26 × Рч65, MS26 × Рч62, MS151 × Рч62 обладают стабильностью в проявлении хозяйственных признаков при испытании в разные годы. The purpose of the study is to evaluate the combinational ability of black radish lines according to the main economically valuable characteristics. The research was carried out in 2019–2020 on the basis of the N.N. Timofeev Breeding Station LLC, a subdivision of the Russian State Agrarian University – MAA named after K.A. Timiryazev, which is located on the territory of Moscow. The soils of the experimental field are medium loamy, sod-podzolic on the cover loam. The material was the black radish lines from the collection of the N.N. Timofeev Breeding Station LLC: sterile lines: MS 26, MS151 and fertile lines: Rch65, Rch62, Rch64, Rch61, RchRyn. The standard is a popular variety of radish Zimnyaya kruglaya chernaya. The evaluation of the combinational ability was carried out by crossing two groups of genotypes. The calculation of the combinational ability was carried out according to the first mathematical model proposed by V.K. Savchenko. The agro-climatic indicators of 2019 and 2020 as a whole did not differ significantly from the long-term average values and are optimal for growing radishes. Bookmark the experience by a randomized method. The sowing scheme is 20 × 50, single-line, 30 plants in a variant, in double repetition. Plant care is generally accepted. Hybrid combinations were evaluated according to the following parameters: root crop mass, leaf mass, root crop diameter and length, yield, root crop shape index. On October 5, 2020, six hybrid combinations were put into storage until April 10, 2021. The hybrid combination MS26 × Rch65, which has a complex of valuable economic characteristics (high yield, average leaf weight, rounded shape of the root crop) can be recommended for station variety testing. The best preservation was noted in hybrid combinations MS151 × Rch65 and MS151 × Ryn (87.38 and 85.80%, respectively). The analysis of the effects of ACS revealed the breeding value of the lines MS151 and Ryn (large mass of root crop), Rch61 (large mass of leaves), MS26, MS151 and Rch62 (rounded shape of the root crop). Hybrid combinations MS26 × Rch65, MS26 × Rch62, MS151 × Rch62 have stability in the manifestation of economic signs when tested in different years.

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6

Hill, Stuart A., Tracy Woodward, Andrew Reger, Rachel Baker, and Theresa Dinse. "Role for the RecBCD Recombination Pathway for pilE Gene Variation in Repair-Proficient Neisseria gonorrhoeae." Journal of Bacteriology 189, no. 22 (September 14, 2007): 7983–90. http://dx.doi.org/10.1128/jb.00980-07.

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ABSTRACT The role of the RecBCD recombination pathway in PilE antigenic variation in Neisseria gonorrhoeae is contentious and appears to be strain dependent. In this study, N. gonorrhoeae strain MS11 recB mutants were assessed for recombination/repair. MS11 recB mutants were found to be highly susceptible to DNA treatments that caused double-chain breaks and were severely impaired for growth; recB growth suppressor mutants arose at high frequencies. When the recombination/repair capacity of strain MS11 was compared to that of strains FA1090 and P9, innate differences were observed between the strains, with FA1090 and P9 rec + bacteria presenting pronounced recombination/repair defects. Consequently, MS11 recB mutants present a more robust phenotype than the other strains that were tested. In addition, MS11 recB mutants are also shown to be defective for pilE/pilS recombination. Moreover, pilE/pilS recombination is shown to proceed with gonococci that carry inverted pilE loci. Consequently, a novel RecBCD-mediated double-chain-break repair model for PilE antigenic variation is proposed.

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7

Ismail, Nor Isnida, Iekhsan Othman, Faridah Abas, Nordin H. Lajis, and Rakesh Naidu. "The Curcumin Analogue, MS13 (1,5-Bis(4-hydroxy-3- methoxyphenyl)-1,4-pentadiene-3-one), Inhibits Cell Proliferation and Induces Apoptosis in Primary and Metastatic Human Colon Cancer Cells." Molecules 25, no. 17 (August 20, 2020): 3798. http://dx.doi.org/10.3390/molecules25173798.

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The cytotoxic and apoptotic effects of turmeric (Curcuma longa) on colon cancer have been well documented but specific structural modifications of curcumin have been shown to possess greater growth-suppressive potential on colon cancer than curcumin. Therefore, the aim of this study is to identify the anti-cancer properties of curcumin analogue-MS13, a diarylpentanoid on the cytotoxicity, anti-proliferative and apoptotic activity of primary (SW480) and metastatic (SW620) human colon cancer cells. A cell viability assay showed that MS13 has greater cytotoxicity effect on SW480 (EC50: 7.5 ± 2.8 µM) and SW620 (EC50: 5.7 ± 2.4 µM) compared to curcumin (SW480, EC50: 30.6 ± 1.4 µM) and SW620, EC50: 26.8 ± 2.1 µM). Treatment with MS13 at two different doses 1X EC50 and 2X EC50 suppressed the colon cancer cells growth with lower cytotoxicity against normal cells. A greater anti-proliferative effect was also observed in MS13 treated colon cancer cells compared to curcumin at 48 and 72 h. Subsequent analysis on the induction of apoptosis showed that MS13 treated cells exhibited morphological features associated with apoptosis. The findings are also consistent with cellular apoptotic activities shown by increased caspase-3 activity and decreased Bcl-2 protein level in both colon cancer cell lines. In conclusion, MS13 able to suppress colon cancer cell growth by inhibiting cell proliferation and induce apoptosis in primary and metastatic human colon cancer cells.

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8

Ram, Sanjay, Jutamas Ngampasutadol, Andrew D. Cox, Anna M. Blom, Lisa A. Lewis, Frank St. Michael, Jacek Stupak, Sunita Gulati, and Peter A. Rice. "Heptose I Glycan Substitutions on Neisseria gonorrhoeae Lipooligosaccharide Influence C4b-Binding Protein Binding and Serum Resistance." Infection and Immunity 75, no. 8 (May 25, 2007): 4071–81. http://dx.doi.org/10.1128/iai.01109-06.

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ABSTRACT Lipooligosaccharide (LOS) heptose (Hep) glycan substitutions influence gonococcal serum resistance. Several gonococcal strains bind the classical complement pathway inhibitor, C4b-binding protein (C4BP), via their porin (Por) molecule to escape complement-dependent killing by normal human serum (NHS). We show that the proximal glucose (Glc) on HepI is required for C4BP binding to Por1B-bearing gonococcal strains MS11 and 1291 but not to FA19 (Por1A). The presence of only the proximal Glc on HepI (lgtE mutant) permitted maximal C4BP binding to MS11 but not to 1291. Replacing 1291 lgtE Por with MS11 Por increased C4BP binding to levels that paralleled MS11 lgtE, suggesting that replacement of the Por1B molecule dictated the effects of HepI glycans on C4BP binding. The remainder of the strain background did not affect C4BP binding; replacing the Por of strain F62 with MS11 Por (F62 PorMS11) and truncating HepI mirrored the findings in the MS11 background. C4BP binding correlated with resistance to killing by NHS in most instances. F62 PorMS11 and its lgtE mutant were sensitive to NHS despite binding C4BP, secondary to kinetically overwhelming classical pathway activation and possibly increased alternative pathway activation (measured by factor Bb binding) by the F62 background. FA19 lgtF (HepI unsubstituted) resisted killing by only 10% NHS, not 50% NHS, despite binding levels of C4BP similar to those of FA19 and FA19 lgtE (both resistant to 50% serum), suggesting a role for the proximal Glc in serum resistance independently of C4BP binding. This study provides mechanistic insights into how HepI LOS substitutions affect the serum resistance of N. gonorrhoeae.

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9

Hazkani-Covo, E. "Mitochondrial Insertions into Primate Nuclear Genomes Suggest the Use of numts as a Tool for Phylogeny." Molecular Biology and Evolution 26, no. 10 (July 3, 2009): 2175–79. http://dx.doi.org/10.1093/molbev/msp131.

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10

Peng, M. S., H. H. Quang, K. P. Dang, A. V. Trieu, H. W. Wang, Y. G. Yao, Q. P. Kong, and Y. P. Zhang. "Tracing the Austronesian Footprint in Mainland Southeast Asia: A Perspective from Mitochondrial DNA." Molecular Biology and Evolution 27, no. 10 (May 31, 2010): 2417–30. http://dx.doi.org/10.1093/molbev/msq131.

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11

Li, Chun, Qi-Gang Li, Jim M. Dunwell, and Yuan-Ming Zhang. "Divergent Evolutionary Pattern of Starch Biosynthetic Pathway Genes in Grasses and Dicots." Molecular Biology and Evolution 29, no. 10 (July 10, 2012): 3227–36. http://dx.doi.org/10.1093/molbev/mss131.

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12

De Maio, Nicola, Christian Schlötterer, and Carolin Kosiol. "Linking Great Apes Genome Evolution across Time Scales Using Polymorphism-Aware Phylogenetic Models." Molecular Biology and Evolution 30, no. 10 (August 1, 2013): 2249–62. http://dx.doi.org/10.1093/molbev/mst131.

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13

Ho, Wei-Chin, and Jianzhi Zhang. "The Genotype–Phenotype Map of Yeast Complex Traits: Basic Parameters and the Role of Natural Selection." Molecular Biology and Evolution 31, no. 6 (April 9, 2014): 1568–80. http://dx.doi.org/10.1093/molbev/msu131.

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14

Caspermeyer, Joseph. "Kissing Cousins, Arranged Marriages, and Genetic Diversity." Molecular Biology and Evolution 32, no. 9 (June 27, 2015): 2498.1–2498. http://dx.doi.org/10.1093/molbev/msv131.

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15

Francois, Clémentine M., Laurent Duret, Laurent Simon, Florian Mermillod-Blondin, Florian Malard, Lara Konecny-Dupré, Rémi Planel, Simon Penel, Christophe J. Douady, and Tristan Lefébure. "No Evidence That Nitrogen Limitation Influences the Elemental Composition of Isopod Transcriptomes and Proteomes." Molecular Biology and Evolution 33, no. 10 (July 8, 2016): 2605–20. http://dx.doi.org/10.1093/molbev/msw131.

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Caspermeyer, Joseph. "So Sheep May Safely Graze: Honing in on Culprit behind Fleece Variation in Domesticated Sheep." Molecular Biology and Evolution 34, no. 7 (May 8, 2017): 1821. http://dx.doi.org/10.1093/molbev/msx131.

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17

Rotem, Assaf, Adrian W. R. Serohijos, Connie B. Chang, Joshua T. Wolfe, Audrey E. Fischer, Thomas S. Mehoke, Huidan Zhang, et al. "Evolution on the Biophysical Fitness Landscape of an RNA Virus." Molecular Biology and Evolution 35, no. 10 (June 28, 2018): 2390–400. http://dx.doi.org/10.1093/molbev/msy131.

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18

Ishikawa, Sohta A., Anna Zhukova, Wataru Iwasaki, and Olivier Gascuel. "A Fast Likelihood Method to Reconstruct and Visualize Ancestral Scenarios." Molecular Biology and Evolution 36, no. 9 (May 24, 2019): 2069–85. http://dx.doi.org/10.1093/molbev/msz131.

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Abstract The reconstruction of ancestral scenarios is widely used to study the evolution of characters along phylogenetic trees. One commonly uses the marginal posterior probabilities of the character states, or the joint reconstruction of the most likely scenario. However, marginal reconstructions provide users with state probabilities, which are difficult to interpret and visualize, whereas joint reconstructions select a unique state for every tree node and thus do not reflect the uncertainty of inferences. We propose a simple and fast approach, which is in between these two extremes. We use decision-theory concepts (namely, the Brier score) to associate each node in the tree to a set of likely states. A unique state is predicted in tree regions with low uncertainty, whereas several states are predicted in uncertain regions, typically around the tree root. To visualize the results, we cluster the neighboring nodes associated with the same states and use graph visualization tools. The method is implemented in the PastML program and web server. The results on simulated data demonstrate the accuracy and robustness of the approach. PastML was applied to the phylogeography of Dengue serotype 2 (DENV2), and the evolution of drug resistances in a large HIV data set. These analyses took a few minutes and provided convincing results. PastML retrieved the main transmission routes of human DENV2 and showed the uncertainty of the human-sylvatic DENV2 geographic origin. With HIV, the results show that resistance mutations mostly emerge independently under treatment pressure, but resistance clusters are found, corresponding to transmissions among untreated patients.

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19

Lercher, M. J. "Evidence That the Human X Chromosome Is Enriched for Male-Specific but not Female-Specific Genes." Molecular Biology and Evolution 20, no. 7 (April 25, 2003): 1113–16. http://dx.doi.org/10.1093/molbev/msg131.

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20

Willyard, Ann, John Syring, David S. Gernandt, Aaron Liston, and Richard Cronn. "Fossil Calibration of Molecular Divergence Infers a Moderate Mutation Rate and Recent Radiations for Pinus." Molecular Biology and Evolution 24, no. 1 (September 22, 2006): 90–101. http://dx.doi.org/10.1093/molbev/msl131.

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21

Wellner, A., and U. Gophna. "Neutrality of Foreign Complex Subunits in an Experimental Model of Lateral Gene Transfer." Molecular Biology and Evolution 25, no. 9 (June 23, 2008): 1835–40. http://dx.doi.org/10.1093/molbev/msn131.

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22

Duffin, Paul M., and H. Steven Seifert. "DNA Uptake Sequence-Mediated Enhancement of Transformation in Neisseria gonorrhoeae Is Strain Dependent." Journal of Bacteriology 192, no. 17 (July 2, 2010): 4436–44. http://dx.doi.org/10.1128/jb.00442-10.

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ABSTRACT Natural transformation is the main means of horizontal genetic exchange in the obligate human pathogen Neisseria gonorrhoeae. Neisseria spp. have been shown to preferentially take up and transform their own DNA by recognizing the nonpalindromic 10- or 12-nucleotide sequence 5′- AT GCCGTCTGAA-3′ (additional semiconserved nucleotides are underlined), termed the DNA uptake sequence (DUS10 or DUS12). Here we investigated the effects of the DUS on transformation and DNA uptake for several laboratory strains of N. gonorrhoeae. We found that all strains showed efficient transformation of DUS containing DNA (DUS10 and DUS12) but that the level of transformation with DNA lacking a DUS (DUS0) was variable in different strains. The DUS-enhanced transformation was 20-fold in two strains, FA1090 and FA19, but was approximately 150-fold in strains MS11 and 1291. All strains tested provide some level of DUS0 transformation, and DUS0 transformation was type IV pilus dependent. Competition with plasmid DNA revealed that transformation of MS11 was enhanced by the addition of excess plasmid DNA containing a DUS while FA1090 transformation was competitively inhibited. Although FA1090 was able to mediate much more efficient transformation of DNA lacking a DUS than was MS11, DNA uptake experiments showed similar levels of uptake of DNA containing and lacking a DUS in FA1090 and MS11. Finally, DNA uptake was competitively inhibited in both FA1090 and MS11. Taken together, our data indicate that the role of the DUS during DNA transformation is variable between strains of N. gonorrhoeae and may influence multiple steps during transformation.

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Yuan, Z., X. Liu, Q. Liu, Z. Liu, C. Tang, Z. Wang, G. Yi, L. Liu, Z. Jiang, and Y. Yang. "MS135 ADIPOPHILIN LOW EXPRESSION REDUCE CELLULAR LIPID." Atherosclerosis Supplements 11, no. 2 (June 2010): 136–37. http://dx.doi.org/10.1016/s1567-5688(10)70636-x.

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LeVan, Adriana, Lindsey I. Zimmerman, Amanda C. Mahle, Karen V. Swanson, Philip DeShong, Juhee Park, Vonetta L. Edwards, Wenxia Song, and Daniel C. Stein. "Construction and Characterization of a Derivative of Neisseria gonorrhoeae Strain MS11 Devoid of AllopaGenes." Journal of Bacteriology 194, no. 23 (September 21, 2012): 6468–78. http://dx.doi.org/10.1128/jb.00969-12.

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ABSTRACTTo better understand the role of Opa in gonococcal infections, we created and characterized a derivative of MS11 (MS11Δopa) that had the coding sequence for all 11 Opa proteins deleted. The MS11Δopa bacterium lost the ability to bind to purified lipooligosaccharide (LOS). While nonpiliated MS11Δopa and nonpiliated Opa-expressing MS11 cells grew at the same rate, nonpiliated MS11Δopa cells rarely formed clumps of more than four bacteria when grown in broth with vigorous shaking. Using flow cytometry analysis, we demonstrated that MS11Δopa produced a homogeneous population of bacteria that failed to bind monoclonal antibody (MAb) 4B12, a MAb specific for Opa. Opa-expressing MS11 cells consisted of two predominant populations, where ∼85% bound MAb 4B12 to a significant level and the other population bound little if any MAb. Approximately 90% of bacteria isolated from a phenotypically Opa-negative colony (a colony that does not refract light) failed to bind MAb 4B12; the remaining 10% bound MAb to various degrees. Piliated MS11Δopa cells formed dispersed microcolonies on ME180 cells which were visually distinct from those of piliated Opa-expressing MS11 cells. When Opa expression was reintroduced into MS11Δopa, the adherence ability of the strain recovered to wild-type levels. These data indicate that Opa contributes to both bacterium-bacterium and bacterium-host cell interactions.

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Dietrich, Manuela, Hans Mollenkopf, Magdalene So, and Alexandra Friedrich. "Pilin regulation in thepilTmutant ofNeisseria gonorrhoeaestrain MS11." FEMS Microbiology Letters 296, no. 2 (July 2009): 248–56. http://dx.doi.org/10.1111/j.1574-6968.2009.01647.x.

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26

Wu, Hong, Ángel A. Soler-García, and Ann E. Jerse. "A Strain-Specific Catalase Mutation and Mutation of the Metal-Binding Transporter Gene mntC Attenuate Neisseria gonorrhoeae In Vivo but Not by Increasing Susceptibility to Oxidative Killing by Phagocytes." Infection and Immunity 77, no. 3 (December 29, 2008): 1091–102. http://dx.doi.org/10.1128/iai.00825-08.

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ABSTRACT The hallmark of gonorrhea is an intense inflammatory response that is characterized by polymorphonuclear leukocytes (PMNs) with intracellular gonococci. A redundancy of defenses may protect Neisseria gonorrhoeae from phagocyte-derived reactive oxygen species. Here we showed that a gonococcal catalase (kat) mutant in strain MS11 was more sensitive to H2O2 than mutants in cytochrome c peroxidase (ccp), methionine sulfoxide reductase (msrA), or the metal-binding protein (mntC) of the MntABC transporter. kat ccp and kat ccp mntC mutants were significantly more sensitive to H2O2 than mutants in any single factor. None of the mutants showed increased susceptibility to murine PMNs. Recovery of the mntC and kat ccp mntC mutants from the lower genital tract of BALB/c mice, but not the kat or kat ccp mutants, was significantly reduced relative to wild-type bacteria. Interestingly, unlike the MS11 kat mutant, a kat mutant of strain FA1090 was attenuated during competitive infection with wild-type FA1090 bacteria. The FA1090 kat mutant and MS11 mntC mutant were also attenuated in mice that are unable to generate a phagocytic respiratory burst. We conclude that inactivation of three well-characterized antioxidant genes (kat, ccp, and mntC) does not increase gonococcal susceptibility to the phagocytic respiratory burst during infection and that gonococcal catalase and the MntC protein confer an unidentified advantage in vivo. In the case of catalase, this advantage is strain specific. Finally, we also showed that an msrA mutant of strain MS11 demonstrated delayed attenuation in BALB/c but not C57BL/6 mice. Therefore, MsrA/B also appears to play a role in infection that is dependent on host genetic background.

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Orekhov, A., E. Andreeva, I. Adrianova, J. Kzhyshkowska, and A. Gratchev. "MS136 CELL PROLIFERATION IN DIFFERENT ATHEROSCLEROTIC LESIONS OF HUMAN ARTERIES." Atherosclerosis Supplements 11, no. 2 (June 2010): 137. http://dx.doi.org/10.1016/s1567-5688(10)70637-1.

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Ferrari Rafael Silva, E., F. A. H. Fonseca, C. N. França, P. R. A. Ferreira, C. M. Monteiro, L. M. Camargo, R. Salomão, S. B. Tenore, and D. S. Lewi. "MS231 ENDOTHELIAL PROGENITORS CELLS AND MICROPARTICLES IN HIV-INFECTED PATIENTS." Atherosclerosis Supplements 11, no. 2 (June 2010): 156. http://dx.doi.org/10.1016/s1567-5688(10)70732-7.

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Cai, G. J. "MS331 ARTERIAL BAROREFLEX FUNCTION IS A NEW TARGET OF ATHEROSCLEROSIS." Atherosclerosis Supplements 11, no. 2 (June 2010): 176. http://dx.doi.org/10.1016/s1567-5688(10)70832-1.

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Choi, Sung-Woo. "Adsorption of CO2 on Monoethanol Amine-Impregnated ZSM5 and MS13X." Journal of Korean Society of Environmental Engineers 39, no. 6 (June 30, 2017): 325–31. http://dx.doi.org/10.4491/ksee.2017.39.6.325.

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Bonalumi, Davide, Stefano Lillia, Giampaolo Manzolini, and Carlos Grande. "Innovative Process Cycle with Zeolite (MS13X) for Post Combustion Adsorption." Energy Procedia 114 (July 2017): 2211–18. http://dx.doi.org/10.1016/j.egypro.2017.03.1358.

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Helm, R. Allen, and H. Steven Seifert. "Pilin Antigenic Variation Occurs Independently of the RecBCD Pathway in Neisseria gonorrhoeae." Journal of Bacteriology 191, no. 18 (July 10, 2009): 5613–21. http://dx.doi.org/10.1128/jb.00535-09.

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ABSTRACT Type IV pilus expression has been strongly implicated in the virulence of Neisseria gonorrhoeae, the causative agent of gonorrhea. In Neisseria, these pili undergo frequent antigenic variation (Av), which is presumed to allow reinfection of high-risk groups. Pilin Av is the result of RecA-mediated recombination events between the gene encoding the major pilin subunit (pilE) and multiple silent pilin locus (pilS) copies, utilizing a RecF-like recombination pathway. The role of RecBCD in pilin Av has been controversial. Previous studies measuring pilin Av in recB and recD mutants in two independent strains of N. gonorrhoeae (MS11 and FA1090) by indirect methods yielded conflicting results. In addition, these two laboratory strains have been suggested to express very different DNA repair capabilities. We show that the FA1090 and MS11 parental strains have similar abilities to repair DNA damage via UV-induced DNA damage, nalidixic acid-induced double-strand breaks, and methyl methanesulfonate-induced alkylation and that RecB and RecD are involved in the repair of these lesions. To test the role of the RecBCD pathway in pilin Av, the rate and frequency of pilin Av were directly measured by sequencing the pilE locus in randomly selected piliated progeny of both MS11 and FA1090 in recB and recD mutants. Our results definitively show that recB and recD mutants undergo pilin Av at rates similar to those of the parents in both strain backgrounds, demonstrating that efficient pilin Av is neither enhanced nor inhibited by the RecBCD complex.

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Hedges, Spencer R., Matthew S. Mayo, Jiri Mestecky, Edward W. Hook, and Michael W. Russell. "Limited Local and Systemic Antibody Responses toNeisseria gonorrhoeae during Uncomplicated Genital Infections." Infection and Immunity 67, no. 8 (August 1, 1999): 3937–46. http://dx.doi.org/10.1128/iai.67.8.3937-3946.1999.

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ABSTRACT Repeated infections with Neisseria gonorrhoeae are common among patients attending sexually transmitted disease clinics. We examined whether previous infections or site of infection altered the local and systemic antigonococcal antibody levels in males and females. Antibodies against N. gonorrhoeae MS11 and the patients’ homologous infecting isolates were measured by enzyme-linked immunosorbent assay. In general, the local and systemic immune responses to gonococci were extremely modest. There was a slight increase in serum immunoglobulin G (IgG) against the MS11 strain and the homologous isolates in infected males. Levels of serum IgA1 antibodies against MS11 were slightly higher in infected than in uninfected females. A history of previous infections with N. gonorrhoeae did not alter the antibody levels in patients with a current infection, suggesting that immunological memory is not induced by uncomplicated gonococcal infections. Antibody responses to infected subjects’ homologous isolates were observed in cervical mucus; IgA1 levels increased while IgG levels decreased. The decline in mucosal IgG against the homologous isolates was less common in subjects having both rectal and cervical infections; otherwise, no effect of rectal involvement was observed. The absence of substantially higher antibody levels to gonococci where there is infection at a site known to contain organized lymphoid tissue suggests that the low levels of responses to uncomplicated infections may not be due simply to an absence of inductive sites in the genital tract. We propose that in addition to its potential ability to avoid the effects of an immune response,N. gonorrhoeae does not elicit strong humoral immune responses during uncomplicated genital infections.

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Mozos, I., and C. Costea. "MS111 SERUM CHOLESTEROL, TRIGLYCERIDES AND THE QT INTERVAL IN HYPERTENSIVE PATIENTS." Atherosclerosis Supplements 11, no. 2 (June 2010): 132. http://dx.doi.org/10.1016/s1567-5688(10)70612-7.

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Savchenko, A., A. Inoue, R. Ohashi, K. Inoue, S. Jiang, G. Hasegawa, and M. Naito. "MS130 EXPRESSION PATTERN OF LONG PENTRAXIN 3 (PTX3) IN HUMAN ATHEROSCLEROSIS." Atherosclerosis Supplements 11, no. 2 (June 2010): 135–36. http://dx.doi.org/10.1016/s1567-5688(10)70631-0.

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Gabbasov, Z., S. Kozlov, O. Saburova, A. Imaeva, O. Vasilieva, S. Domogatsky, and V. Kucharchuk. "MS139 IN-STENT RESTENOSIS IS ACCOMPANIED BY ELEVATION OF CIRCULATING EOSINOPHILS." Atherosclerosis Supplements 11, no. 2 (June 2010): 137. http://dx.doi.org/10.1016/s1567-5688(10)70640-1.

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Coleman, L. "MS431 THE RELATIONSHIP OF STRESS TO PATHOLOGY, PHYSIOLOGY, ANESTHESIA AND ANALGESIA." Atherosclerosis Supplements 11, no. 2 (June 2010): 197. http://dx.doi.org/10.1016/s1567-5688(10)70932-6.

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Seldenrijk, A., M. Hamer, B. Penninx, and A. Steptoe. "MS531 POOR MENTAL HEALTH, HPA AXIS REACTIVITY AND SUBCLINICAL CORONARY CALCIFICATION." Atherosclerosis Supplements 11, no. 2 (June 2010): 216. http://dx.doi.org/10.1016/s1567-5688(10)71031-x.

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Snedecor, SJ. "MSR31 Evidence Synthesis for Decision-Making: Is Meta-Analysis Always Required?" Value in Health 25, no. 12 (December 2022): S355—S356. http://dx.doi.org/10.1016/j.jval.2022.09.1763.

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Long, Cynthia D., Stanley F. Hayes, Jos P. M. van Putten, Hillery A. Harvey, Michael A. Apicella, and H. Steven Seifert. "Modulation of Gonococcal Piliation by Regulatable Transcription of pilE." Journal of Bacteriology 183, no. 5 (March 1, 2001): 1600–1609. http://dx.doi.org/10.1128/jb.183.5.1600-1609.2001.

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ABSTRACT The gonococcal pilus, a member of the type IV family of pili, is composed of numerous monomers of the pilin protein and plays an important role in the initiation of disease by providing the primary attachment of the bacterial cell to human mucosal tissues. Piliation also correlates with efficient DNA transformation. To investigate the relationships between these pilus-related functions, the piliation state, and the availability of pilin, we constructed a derivative of MS11-C9 (ΔpilE1) in which the lacIOPregulatory sequences control pilE transcription. In this strain, MS11-C9.10, the steady-state levels of pilin mRNA and protein directly correlate with the concentration of IPTG (isopropyl-β-d-thiogalactopyranoside) in the growth medium and can reach near-wild-type levels of expression. Transmission electron microscopy (TEM) demonstrated that the number of pili per cell correlated with the steady-state expression levels: at a low level of transcription, single long pili were observed; at a moderate expression level, many singular and bundled pili were expressed; and upon full gene expression, increased lateral association between pili was observed. Analysis of pilus assembly by TEM and epithelial cell adherence over a time course of induction demonstrated that pili were expressed as early as 1 h postinduction. Analysis at different steady-state levels of transcription demonstrated that DNA transformation efficiency and adherence of MS11-C9.10 to transformed and primary epithelial cells also correlated with the level of piliation. These data show that modulation of the level ofpilE transcription, without a change in pilEsequence, can alter the number of pili expressed per cell, pilus bundling, DNA transformation competence, and epithelial cell adherence of the gonococcus.

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Rapp, Peter, and Lotte H. E. Gabriel-Jürgens. "Degradation of alkanes and highly chlorinated benzenes, and production of biosurfactants, by a psychrophilic Rhodococcus sp. and genetic characterization of its chlorobenzene dioxygenase." Microbiology 149, no. 10 (October 1, 2003): 2879–90. http://dx.doi.org/10.1099/mic.0.26188-0.

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Rhodococcus sp. strain MS11 was isolated from a mixed culture. It displays a diverse range of metabolic capabilities. During growth on 1,2,4-trichlorobenzene, 1,2,4,5-tetrachlorobenzene (1,2,4,5-TeCB) and 3-chlorobenzoate stoichiometric amounts of chloride were released. It also utilized all three isomeric dichlorobenzenes and 1,2,3-trichlorobenzene as the sole carbon and energy source. Furthermore, the bacterium grew well on a great number of n-alkanes ranging from n-heptane to n-triacontane and on the branched alkane 2,6,10,14-tetramethylpentadecane (pristane) and slowly on n-hexane and n-pentatriacontane. It was able to grow at temperatures from 5 to 30 °C, with optimal growth at 20 °C, and could tolerate 6 % NaCl in mineral salts medium. Genes encoding the initial chlorobenzene dioxygenase were detected by using a primer pair that was designed against the α-subunit (TecA1) of the chlorobenzene dioxygenase of Ralstonia (formerly Burkholderia) sp. strain PS12. The amino acid sequence of the amplified part of the α-subunit of the chlorobenzene dioxygenase of Rhodococcus sp. strain MS11 showed >99 % identity to the α-subunit of the chlorobenzene dioxygenase from Ralstonia sp. strain PS12 and the parts of both α-subunits responsible for substrate specificity were identical. The subsequent enzymes dihydrodiol dehydrogenase and chlorocatechol 1,2-dioxygenase were induced in cells grown on 1,2,4,5-TeCB. During cultivation on medium-chain-length n-alkanes ranging from n-decane to n-heptadecane, including 1-hexadecene, and on the branched alkane pristane, strain MS11 produced biosurfactants lowering the surface tension of the cultures from 72 to ⩽29 mN m−1. Glycolipids were extracted from the supernatant of a culture grown on n-hexadecane and characterized by 1H- and 13C-NMR-spectroscopy and mass spectrometry. The two major components consisted of α,α-trehalose esterified at C-2 or C-4 with a succinic acid and at C-2′ with a decanoic acid. They differed from one another in that one 2,3,4,2′-trehalosetetraester, found in higher concentration, was esterified at C-2, C-3 or C-4 with one octanoic and one decanoic acid and the other one, of lower concentration, with two octanoic acids. The results demonstrate that Rhodococcus sp. strain MS11 may be well suited for bioremediation of soils and sediments contaminated for a long time with di-, tri- and tetrachlorobenzenes as well as alkanes.

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42

Nateras Domínguez, Alfredo. "Violencia simbólica y significación de los cuerpos: Tatuajes en jóvenes." Revista Temas Sociológicos, no. 11 (January 23, 2017): 71. http://dx.doi.org/10.29344/07194145.11.204.

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ResumenLa intención de este texto es discutir el concepto de violencia en tanto problemática compleja que se expresa a través de distintos rostros. La violencia simbólica ejercida es muy visible en contra de ciertas acciones sociales y manifestaciones culturales de algunos jóvenes (por ejemplo, en la significación del cuerpo). Por esto, interesa situar la práctica del tatuaje, a partir del cual se construyen procesos de identidades duras en adscripciones juveniles como la de los “Cholos”1y “la Mara Salvatrucha MS13”2.Palabras clave: violencias, jóvenes, tatuajes, cuerpo, identidades.AbstractThe intention of this text is to discuss the concept of violence as a complex problematic that is expressed through different faces. The symbolic violence executed is very visible against certain social actions and cultural manifestations of some youngs (for example, in the significance of the body. For this, the main interest the practice of tattoo, from which processes of hard identities are constructed in youth adscriptions as the ones of the “Cholos” and the “Mara Salvatrucha MS13”.Key words: violences, youngs, tatoos, body, identities

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Nateras Domínguez, Alfredo. "Violencia simbólica y significación de los cuerpos: Tatuajes en jóvenes." Revista Temas Sociológicos, no. 11 (January 23, 2017): 71. http://dx.doi.org/10.29344/07196458.11.204.

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ResumenLa intención de este texto es discutir el concepto de violencia en tanto problemática compleja que se expresa a través de distintos rostros. La violencia simbólica ejercida es muy visible en contra de ciertas acciones sociales y manifestaciones culturales de algunos jóvenes (por ejemplo, en la significación del cuerpo). Por esto, interesa situar la práctica del tatuaje, a partir del cual se construyen procesos de identidades duras en adscripciones juveniles como la de los “Cholos”1y “la Mara Salvatrucha MS13”2.Palabras clave: violencias, jóvenes, tatuajes, cuerpo, identidades.AbstractThe intention of this text is to discuss the concept of violence as a complex problematic that is expressed through different faces. The symbolic violence executed is very visible against certain social actions and cultural manifestations of some youngs (for example, in the significance of the body. For this, the main interest the practice of tattoo, from which processes of hard identities are constructed in youth adscriptions as the ones of the “Cholos” and the “Mara Salvatrucha MS13”.Key words: violences, youngs, tatoos, body, identities

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Helm, R. Allen, and H. Steven Seifert. "Frequency and Rate of Pilin Antigenic Variation of Neisseria meningitidis." Journal of Bacteriology 192, no. 14 (May 14, 2010): 3822–23. http://dx.doi.org/10.1128/jb.00280-10.

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ABSTRACT The rates of pilin antigenic variation (Av) of two strains of Neisseria meningitidis were determined using an unbiased DNA sequencing assay. Strain MC58 underwent pilin Av at a rate similar to that of N. gonorrhoeae strain MS11 but lower than that of N. gonorrhoeae strain FA1090. Pilin Av was undetectable in strain FAM18.

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Klyueva, N., S. Tsikunov, A. Denisenko, and A. Pshenichnaya. "MS121 LIPID LEVEL OF PLASMA IN RATS AND THEIR BEHAVIOR AFTER SHOCK." Atherosclerosis Supplements 11, no. 2 (June 2010): 134. http://dx.doi.org/10.1016/s1567-5688(10)70622-x.

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Gil-Dones, F., C. M. Laborde, S. Alonso-Orgaz, J. Moreu, F. Vivanco, L. R. Padial, and M. G. Barderas. "MS132 QUANTITATIVE PROTEOMIC APPROACH TO IDENTIFY PROTEINS INVOLVED IN ACUTE CORONARY SYNDROME." Atherosclerosis Supplements 11, no. 2 (June 2010): 136. http://dx.doi.org/10.1016/s1567-5688(10)70633-4.

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47

Dencker, M., O. Thorsson, M. K. Karlsson, C. Lindén, P. Wollmer, and L. B. Andersen. "MS191 BODY FAT RELATED TO RISK FACTORS FOR CVD IN YOUNGER CHILDREN." Atherosclerosis Supplements 11, no. 2 (June 2010): 148. http://dx.doi.org/10.1016/s1567-5688(10)70692-9.

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Charalampous, C., and S. Patiakas. "MS311 CORRELATION OF METABOLIC SYNDROME AND CEREBRAL VASCULAR STROKE IN ELDERLY PATIENTS." Atherosclerosis Supplements 11, no. 2 (June 2010): 172. http://dx.doi.org/10.1016/s1567-5688(10)70812-6.

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49

Skvortsov, A. A., G. D. Oreshkin, A. I. Kondrat, A. A. Medvedev, and P. A. Saburov. "Main Results of Training and Activity of the ISS-60/61 Crew Members When Carrying Out the Mission Plan." MANNED SPACEFLIGHT, no. 2(35) (June 1, 2020): 5–22. http://dx.doi.org/10.34131/msf.20.2.5-22.

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The paper represents the ISS-60/61 crew members, main tasks and results of crew training. Special attention is paid to the crew activity aboard the Soyuz-MS13 manned transport vehicle (MTV) and ISS. The EVA operations performed according to the program of the ISS USOS (US Orbital Segment) are briefly reviewed. The paper contains preliminary analysis of the Russian scientific program of applied research and experiments.

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Apostolou, F., I. Gazi, V. Saougos, A. Tselepis, M. Elisaf, and E. Liberopoulos. "MS101 EVIDENCE OF INCREASED SDLDL PARTICLES DURING ACUTE INFECTION WITH EPSTEIN–BARR VIRUS." Atherosclerosis Supplements 11, no. 2 (June 2010): 130. http://dx.doi.org/10.1016/s1567-5688(10)70602-4.

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