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Academic literature on the topic 'MRtrix'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "MRtrix"

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Tournier, J.-Donald, Fernando Calamante, and Alan Connelly. "MRtrix: Diffusion tractography in crossing fiber regions." International Journal of Imaging Systems and Technology 22, no. 1 (February 14, 2012): 53–66. http://dx.doi.org/10.1002/ima.22005.

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Noriega-Gonzalez, David C., Jesús Crespo, Francisco Ardura, Juan Calabia-del Campo, Carlos Alberola-Lopez, Rodrigo de Luis-García, Alberto Caballero-García, and Alfredo Córdova. "Cerebral White Matter Connectivity in Adolescent Idiopathic Scoliosis: A Diffusion Magnetic Resonance Imaging Study." Children 9, no. 7 (July 10, 2022): 1023. http://dx.doi.org/10.3390/children9071023.

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Adolescent idiopathic scoliosis (AIS) is characterized by the radiographic presence of a frontal plane curve, with a magnitude greater than 10° (Cobb technique). Diffusion MRI can be employed to assess the cerebral white matter. The aim of this study was to analyze, by means of MRI, the presence of any alteration in the connectivity of cerebral white matter in AIS patients. In this study, 22 patients with AIS participated. The imaging protocol consisted in T1 and diffusion-weighted acquisitions. Based on the information from one of the diffusion acquisitions, a whole brain tractography was performed with the MRtrix tool. Tractography is a method to deduce the trajectory of fiber bundles through the white matter based on the diffusion MRI data. By combining cortical segmentation with tractography, a connectivity matrix of size 84 × 84 was constructed using FA (fractional anisotropy), and the number of streamlines as connectomics metrics. The results obtained support the hypothesis that alterations in cerebral white matter connectivity in patients with adolescent idiopathic scoliosis (AIS) exist. We consider that the application of diffusion MRI, together with transcranial magnetic stimulation neurophysiologically, is useful to search the etiology of AIS.
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Coenen, Volker A., Bastian E. Sajonz, Peter C. Reinacher, Christoph P. Kaller, Horst Urbach, and M. Reisert. "A detailed analysis of anatomical plausibility of crossed and uncrossed streamline rendition of the dentato-rubro-thalamic tract (DRT(T)) in a commercial stereotactic planning system." Acta Neurochirurgica 163, no. 10 (June 28, 2021): 2809–24. http://dx.doi.org/10.1007/s00701-021-04890-4.

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Abstract Background An increasing number of neurosurgeons use display of the dentato-rubro-thalamic tract (DRT) based on diffusion weighted imaging (dMRI) as basis for their routine planning of stimulation or lesioning approaches in stereotactic tremor surgery. An evaluation of the anatomical validity of the display of the DRT with respect to modern stereotactic planning systems and across different tracking environments has not been performed. Methods Distinct dMRI and anatomical magnetic resonance imaging (MRI) data of high and low quality from 9 subjects were used. Six subjects had repeated MRI scans and therefore entered the analysis twice. Standardized DICOM structure templates for volume of interest definition were applied in native space for all investigations. For tracking BrainLab Elements (BrainLab, Munich, Germany), two tensor deterministic tracking (FT2), MRtrix IFOD2 (https://www.mrtrix.org), and a global tracking (GT) approach were used to compare the display of the uncrossed (DRTu) and crossed (DRTx) fiber structure after transformation into MNI space. The resulting streamlines were investigated for congruence, reproducibility, anatomical validity, and penetration of anatomical way point structures. Results In general, the DRTu can be depicted with good quality (as judged by waypoints). FT2 (surgical) and GT (neuroscientific) show high congruence. While GT shows partly reproducible results for DRTx, the crossed pathway cannot be reliably reconstructed with the other (iFOD2 and FT2) algorithms. Conclusion Since a direct anatomical comparison is difficult in the individual subjects, we chose a comparison with two research tracking environments as the best possible “ground truth.” FT2 is useful especially because of its manual editing possibilities of cutting erroneous fibers on the single subject level. An uncertainty of 2 mm as mean displacement of DRTu is expectable and should be respected when using this approach for surgical planning. Tractographic renditions of the DRTx on the single subject level seem to be still illusive.
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Fayaz, Mohamed Salah, Gerges Attia Demian, Wael Moftah Fathallah, Heba El-Sayed Eissa, Mustafa Shawki El-Sherify, Sadeq Abozlouf, Thomas George, and Suzanne Mona Samir. "Significance of Magnetic Resonance Imaging–Assessed Tumor Response for Locally Advanced Rectal Cancer Treated With Preoperative Long-Course Chemoradiation." Journal of Global Oncology 2, no. 4 (August 2016): 216–21. http://dx.doi.org/10.1200/jgo.2015.001479.

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Purpose To study the predictive and prognostic value of magnetic resonance imaging (MRI)–assessed tumor response after long-course neoadjuvant therapy for locally advanced rectal cancer. Methods This study included 79 patients who had T3 or T4 and/or N+ rectal cancer treated with long-course neoadjuvant chemoradiation. MRI-assessed tumor regression grade (mrTRG) was assessed in 64 patients. MRIs were reviewed by the study radiologist. Surgical and pathologic reports for those who underwent surgery were reviewed. Disease-free survival (DFS) was estimated. Progression during therapy, local relapse, metastasis, and death resulting from the tumor were classified as events. Statistical significance was calculated. Results In 11 patients, the tumor completely disappeared on MRI; that is, it had an mrTRG of 1. All but one patient, who chose deferred surgery, had a complete pathologic response (pCR), with a positive predictive value of nearly 100%. Of the 20 patients who had an mrTRG of 2 on MRI, six had a pCR. mrTRG 3, mrTRG 4, and mrTRG 5 were detected in 24, six, and three patients, respectively, of whom only one patient had a pCR. The 2-year DFS was 77%. The mrTRG was significant for DFS. The 2-year DFS was 88% for patients with a good response versus 66% for those with a poor response (P = .046). Conclusion MRI-assessed complete tumor response was strongly correlated with pCR and, therefore, can be used as a surrogate marker to predict absence of viable tumor cells. Our results can be used to implement use of mrTRGs in larger prospective correlative studies as a tool to select patients for whom deferred surgery may be appropriate. Also, those with a poor response may be offered further treatment options before definitive surgery.
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McCormick, Susan P., and Nancy J. Alexander. "Myrothecium roridum Tri4 encodes a multifunctional oxygenase required for three oxygenation steps." Canadian Journal of Microbiology 53, no. 5 (May 2007): 572–79. http://dx.doi.org/10.1139/w07-025.

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The biosyntheses of both macrocyclic trichothecenes in Myrothecium roridum and simple trichothecenes in Fusarium species begin with the cyclization of farnesyl pyrophosphate to form the sesquiterpene hydrocarbon trichodiene. A previous study showed that Myrothecium has a cluster of 3 genes that are homologous with Fusarium trichothecene genes: Tri4, a P450 oxygenase; Tri5, the sesquiterpene cyclase; and Tri6, a zinc-finger regulatory gene. Fusarium graminearum Tri4 (FgTri4) and M. roridum MrTri4 (MrTri4) have 66.9% identity. In this study, MrTri4 was expressed in Fusarium verticillioides . Liquid cultures of transformant strains expressing MrTri4 converted exogenous trichodiene to isotrichodiol, indicating that MrTri4 controls 3 oxygenation steps and that the product of MrTRI4 is isotrichodiol.
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Zheng, Huiming, Zengtao Zhong, Xin Lai, Wen-Xin Chen, Shunpeng Li, and Jun Zhu. "A LuxR/LuxI-Type Quorum-Sensing System in a Plant Bacterium, Mesorhizobium tianshanense, Controls Symbiotic Nodulation." Journal of Bacteriology 188, no. 5 (March 1, 2006): 1943–49. http://dx.doi.org/10.1128/jb.188.5.1943-1949.2006.

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ABSTRACT The ability of rhizobia to symbiotically fix nitrogen from the atmosphere when forming nodules on their plant hosts requires various signal transduction pathways. LuxR-LuxI-type quorum-sensing systems have been shown to be one of the players in a number of rhizobium species. In this study, we found that Mesorhizobium tianshanense, a moderate-growth Rhizobium that forms nodules on a number of licorice plants, produces multiple N-acyl homoserine lactone (AHL)-like molecules. A simple screen for AHL synthase genes using an M. tianshanense genomic expression library in Escherichia coli, coupled with a sensitive AHL detector, uncovered a LuxI-type synthase, MrtI, and a LuxR-type regulator, MrtR, in M. tianshanense. Deletions of the mrtI or mrtR locus completely abolished AHL production in M. tianshanense. Using lacZ transcriptional fusions, we found that expression of the quorum-sensing regulators is autoinduced, as mrtI gene expression requires MrtR and cognate AHLs and mrtR expression is dependent on AHLs. Compared with the wild-type strains, quorum-sensing-deficient mutants showed a marked reduction in the efficiency of root hair adherence and, more importantly, were defective in nodule formation on their host plant, Glycyrrhiza uralensis. These data provide strong evidence that quorum sensing plays a critical role in the M. tianshanense symbiotic process.
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Muller, Jennifer, Mahdi Alizadeh, Feroze B. Mohamed, Jonathan Riley, John J. Pearce, Benjamin Trieu, Tsao-Wei Liang, Victor Romo, Ashwini Sharan, and Chengyuan Wu. "Clinically applicable delineation of the pallidal sensorimotor region in patients with advanced Parkinson’s disease: study of probabilistic and deterministic tractography." Journal of Neurosurgery 131, no. 5 (November 2019): 1520–31. http://dx.doi.org/10.3171/2018.7.jns18541.

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OBJECTIVEDeep brain stimulation (DBS) is an effective procedure in improving motor symptoms for patients with advanced Parkinson’s disease (PD) through the use of high-frequency stimulation. Although one of the most commonly used target sites for DBS, sensorimotor regions of the globus pallidus interna (GPi) have yet to be thoroughly described with advanced neuroimaging analysis in vivo for human subjects. Furthermore, many imaging studies to date have been performed in a research setting and bring into question the feasibility of their applications in a clinical setting, such as for surgical planning. This study compares two different tractography methods applied to clinically feasible acquisition sequences in identifying sensorimotor regions of the GPi and the subthalamic nucleus (STN) in patients with advanced PD selected to undergo DBS.METHODSSeven patients with refractory PD selected for DBS were examined by MRI. Diffusion images were acquired with an average acquisition time of 15 minutes. Probabilistic and deterministic tractography methods were applied to each diffusion-weighted data set using FSL and MRtrix, respectively. Fiber assignment was performed using combined sensorimotor areas as initiation seeds and the STN and GPi, separately, as inclusion masks. Corticospinal tracts were excluded by setting the cerebral peduncles as exclusion masks. Variability between proposed techniques was shown using center of gravity (CoG) coordinates.RESULTSDeterministic and probabilistic corticopallidal and corticosubthalamic pathways were successfully reconstructed for all subjects across all target sites (bilaterally). Both techniques displayed large connections between the sensorimotor cortex with the posterolateral aspect of the ipsilateral GPi and the posterosuperolateral aspect of the ipsilateral STN. The average variability was 2.67 mm, with the probabilistic method identifying the CoG consistently more posterior and more lateral than the deterministic method.CONCLUSIONSSuccessful delineation of the sensorimotor regions in both the GPi and STN is achievable within a clinically reasonable timeframe. The techniques described in this paper may enhance presurgical planning with increased accuracy and improvement of patient outcomes in patients undergoing DBS. The variability found between tracking techniques warrants the use of the probabilistic tractography method over the deterministic method for presurgical planning. Probabilistic tractography was found to have an advantage over deterministic tractography in its sensitivity, in accurately describing previously described tracts, and in its ability to detect a larger number of fibers.
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Meijer, Kim A., Martijn D. Steenwijk, Linda Douw, Menno M. Schoonheim, and Jeroen J. G. Geurts. "Long-range connections are more severely damaged and relevant for cognition in multiple sclerosis." Brain 143, no. 1 (November 15, 2019): 150–60. http://dx.doi.org/10.1093/brain/awz355.

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Abstract An efficient network such as the human brain features a combination of global integration of information, driven by long-range connections, and local processing involving short-range connections. Whether these connections are equally damaged in multiple sclerosis is unknown, as is their relevance for cognitive impairment and brain function. Therefore, we cross-sectionally investigated the association between damage to short- and long-range connections with structural network efficiency, the functional connectome and cognition. From the Amsterdam multiple sclerosis cohort, 133 patients (age = 54.2 ± 9.6) with long-standing multiple sclerosis and 48 healthy controls (age = 50.8 ± 7.0) with neuropsychological testing and MRI were included. Structural connectivity was estimated from diffusion tensor images using probabilistic tractography (MRtrix 3.0) between pairs of brain regions. Structural connections were divided into short- (length < quartile 1) and long-range (length > quartile 3) connections, based on the mean distribution of tract lengths in healthy controls. To determine the severity of damage within these connections, (i) fractional anisotropy as a measure for integrity; (ii) total number of fibres; and (iii) percentage of tract affected by lesions were computed for each connecting tract and averaged for short- and long-range connections separately. To investigate the impact of damage in these connections for structural network efficiency, global efficiency was computed. Additionally, resting-state functional connectivity was computed between each pair of brain regions, after artefact removal with FMRIB’s ICA-based X-noiseifier. The functional connectivity similarity index was computed by correlating individual functional connectivity matrices with an average healthy control connectivity matrix. Our results showed that the structural network had a reduced efficiency and integrity in multiple sclerosis relative to healthy controls (both P < 0.05). The long-range connections showed the largest reduction in fractional anisotropy (z = −1.03, P < 0.001) and total number of fibres (z = −0.44, P < 0.01), whereas in the short-range connections only fractional anisotropy was affected (z = −0.34, P = 0.03). Long-range connections also demonstrated a higher percentage of tract affected by lesions than short-range connections, independent of tract length (P < 0.001). Damage to long-range connections was more strongly related to structural network efficiency and cognition (fractional anisotropy: r = 0.329 and r = 0.447. number of fibres r = 0.321 and r = 0.278. and percentage of lesions: r = −0.219; r = −0.426, respectively) than damage to short-range connections. Only damage to long-distance connections correlated with a more abnormal functional network (fractional anisotropy: r = 0.226). Our findings indicate that long-range connections are more severely affected by multiple sclerosis-specific damage than short-range connections. Moreover compared to short-range connections, damage to long-range connections better explains network efficiency and cognition.
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Obradović, Nadežda, and Vida Ognjenović. "Kuća mrtvih mirisa." World Literature Today 70, no. 4 (1996): 991. http://dx.doi.org/10.2307/40152462.

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Shoja, A., H. Mazaheri, and R. Sarikhani. "λ -fuzzy Fixed Points In Fuzzy Mrtric Spaces." Journal of Mathematics and Computer Science 09, no. 04 (April 29, 2014): 332–41. http://dx.doi.org/10.22436/jmcs.09.04.09.

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Dissertations / Theses on the topic "MRtrix"

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Ait-Daoud, Sanaa. "Le management responsable des technologies de l'information (MRTI) : entre approches ethique et institutionnelle." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20134/document.

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Cette recherche porte sur l'analyse des pratiques et motivations du Management Responsable des Technologies de l'Information (MRTI). Notre premier objectif est de comprendre comment se déclinent le Développement Durable (DD) et la Responsabilité Sociale des Entreprises (RSE) dans la fonction Systèmes d'Information (SI). Le second objectif est de comprendre les motivations de la mise en place d'un MRTI. La réponse à ces objectifs est bâtie en conjuguant recherche empirique et approches théoriques. Ce faisant, un cadre original d'analyse des motivations éthiques et institutionnelles du MRTI est élaboré et vérifié. L'analyse des résultats, à différents stades de la recherche, a permis de proposer (1) une typologie des Green IT, (2) une proposition de modèle de cycle de vie d'un MRTI et (3) une typologie des différentes stratégies (active, pro-active, réactive et rétroactive) des organisations face aux pressions environnementales
This research focuses on the analysis of the motivations and practices of Responsible Management of Information Technology (RMIT). Our first goal is to understand how Sustainable Development (SD) and Corporate Social Responsibility (CSR) are reflected in Information Systems (IS). The second objective is to understand the motivations of establishing a RMIT. The answer for these objectives is built by combining empirical and theoretical approaches. In so doing, an original analysis frame of ethical and institutional motivations for RMIT is developed and verified. The analysis of the results, at various levels of the research, has to offer (1) a Green IT typology, (2) a RMIT life cycle proposal and (3) a typology of organization strategies (active, pro-active, reactive and retrospective) facing environmental pressures
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Lannan, Olivia. "Validation of MRtrix tractography for clinical use." Thesis, 2021. https://hdl.handle.net/2440/135391.

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Tractography is a technique which uses non-invasive diffusion magnetic resonance imaging (dMRI) to model the structural connections of the brain in vivo. Since it is not known to what extent the exact positions of white matter tracts vary between individuals, and how scan parameters affect the reconstructed location of tracts, the performance of tractography algorithms cannot be assessed by comparing them against a standardised model of white matter in the human brain. Until technology has advanced to a stage where these issues can be resolved, if this is indeed possible, the quality of tractograms must be assessed via alternative means if they are to be used in a clinical setting. MRtrix is a software package which offers a suite of tools for tractography. To investigate the clinical viability of tractography, the effect of adding artificial noise and patient movement to the input dMRI scans was examined. The performance of the following three MRtrix tractography algorithms was considered: the second-order integration over fibre orientation distributions (iFOD2) algorithm, the spherical deconvolution streamlines tractography (SD_STREAM) algorithm, and the probabilistic tractography (Tensor_Prob) algorithm. The accuracy of each tractogram and its robustness to added noise and motion was assessed through both quantitative and qualitative means. Streamline length histograms, polar plots, a resemblance metric, the RMS difference between tractmaps and polar plots, and false positive and negative rates were used to quantitatively measure tractogram quality. Each of these techniques provide measures of quality relative to an initial unmodified scan. Potentially, these techniques could be extended to provide a stand-alone metric of tractogram quality to eliminate operator dependence in diagnosing, treating and managing conditions associated with the integrity of white matter pathways in the brain. The tractography algorithm found to be most suitable for clinical applications was iFOD2, which provided the highest level of detail compared with the SD_STREAM and Tensor_Prob algorithms. iFOD2 was capable of consistently resolving tracts with added noise of up to about an added white Gaussian noise (WGN) of power 20, or a SNR of about 8 for the majority of patients (calculated using the single image method). Additionally, the iFOD2 algorithm successfully reconstructed tractograms with added translations up to 5 mm, and rotations up to 10 degrees, despite the reconstructed tracts being spatially shifted.
Thesis (MPhil.) -- University of Adelaide, School of Physical Sciences, 2022
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Books on the topic "MRtrix"

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Zorko, Marko. Knjiga mrtvih. Ljubljana: Mladina, 2007.

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Kiš, Danilo. Enciklopedija mrtvih. Beograd: Prosveta, 1985.

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Kiš, Danilo. Enciklopedija mrtvih. 2nd ed. Beograd: Beogradski Izdavačko-Grafički Zavod, 1994.

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Đurđevac, Ana Briški, and Tomislav Zagoda, eds. Biblioteka mrtvih. Zagreb, Croatia: Znanje, 2012.

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Cuculić, Dražen. Društvo mrtvih pjesnika. Rijeka: Izdavački centar Rijeka, 1995.

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Radak, Vladislav. Noć mrtvih snova. Beograd: Dobra knjiga, 2009.

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Kraus, Pavel. Teprve mrtví zmlknou. Praha: NAVA, 1996.

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Kuća mrtvih mirisa. 6th ed. Beograd: Prosveta, 2000.

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Srpska knjiga mrtvih. Niš: Gradina, 1992.

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Cundrič, Valentin. Slovenska knjiga mrtvih. Kranj: Nova Atlantida, 1998.

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Book chapters on the topic "MRtrix"

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Göbler, Frank, and Angela Richter. "Kiš, Danilo: Enciklopedija mrtvih." In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_655-1.

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Blečić Kavur, Martina. "Življenje ob meji je nevarno in težko. Skupnosti mrtvih, družbe živih: poznobronastodobno grobišče v Zavrču." In Mikro in makro. Pristopi in prispevki k humanističnim vedam ob dvajsetletnici UP Fakultete za humanistične študije, 1. knjiga, 49–62. Založba Univerze na Primorskem, 2020. http://dx.doi.org/10.26493/978-961-7023-13-8(1).49-62.

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"The Valuation of Care Homes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Philip CL Hall BSc (Hons); BTP, DMS, MRTPI, MCMI, MRICS Director, GLP Taylors." In Valuation, 611–28. Estates Gazette, 2014. http://dx.doi.org/10.4324/9781315040783-34.

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"The Landlord and Tenant Act 1954 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Prof. Del W Williams BA, MCD, LLB, FRICS, MRTPI, ACIArb R W Solutions Ltd, Liverpool." In Valuation, 135–48. Estates Gazette, 2014. http://dx.doi.org/10.4324/9781315040783-16.

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Conference papers on the topic "MRtrix"

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Moran, Jesus, Claudio de la Riva, and Javier Tuya. "MRTree: Functional Testing Based on MapReduce's Execution Behaviour." In 2014 2nd International Conference on Future Internet of Things and Cloud (FiCloud). IEEE, 2014. http://dx.doi.org/10.1109/ficloud.2014.67.

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Onuki, Teppei, Shunsuke Kan, Wangpiao Lin, Wentong Lu, Kousuke Hasegawa, Hirotaka Ojima, Jun Shimizu, and Libo Zhou. "Investigation of Crystallographic Aspects of Subsurface Damage Induced by Grinding Using Micro-Raman Tomographic Imaging." In JSME 2020 Conference on Leading Edge Manufacturing/Materials and Processing. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/lemp2020-8514.

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Abstract The objective of this study is to propose and develop an evaluation method on the process damages of sapphire wafers, regarding crystallographic aspects of the damages by use of tomographic imaging techniques with laser Raman microscopy (called as micro Raman tomographic imaging: mRTI). In this paper, tomographic images with the peak width and the shift of the peak position were observed with mRTI, on c-plane cut sapphire wafers along a-plane, with micro fractures induced by brittle-mode grinding. Fractures along m-plane from the surface to 2–7 microns-depth, and fractures along r-plane from the bottom end of the m-plane fracture to 14 microns-depth, subsequently induced elastic strain field around the fractures, could be visualized without destructions of the wafers.
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Fahim, Abdulrahman, and Tamer ElBatt. "Multi-reader RFID tag identification using bit tracking (MRTI-BT)." In 2016 IEEE International Conference on RFID (RFID). IEEE, 2016. http://dx.doi.org/10.1109/rfid.2016.7488019.

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Stauffer, P. R., Oana I. Craciunescu, P. F. Maccarini, Cory Wyatt, K. Arunachalam, O. Arabe, V. Stakhursky, et al. "Clinical utility of magnetic resonance thermal imaging (MRTI) for realtime guidance of deep hyperthermia." In SPIE BiOS: Biomedical Optics, edited by Thomas P. Ryan. SPIE, 2009. http://dx.doi.org/10.1117/12.812188.

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Feng, Yusheng, David Fuentes, Andrea Hawkins, and J. Tinsley Oden. "MRTI-Based Optimization and Real-Time Laser Surgical Control for Cancer Treatment Using Fast Inverse Analysis Techniques." In 2008 International Conference on Biomedical Engineering And Informatics (BMEI). IEEE, 2008. http://dx.doi.org/10.1109/bmei.2008.282.

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Whitney, Jon, Saugata Sarkar, Xuanfeng Ding, Ravi Singh, Andrew Burke, Suzy Torti, and Marissa Nichole Rylander. "Computational Models and Digital Image Analysis of Carbon Nanotube Mediated Laser Cancer Therapy." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53984.

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Laser-based photothermal therapy can provide a minimally invasive treatment alternative to surgical resection of tumors. The selectivity and effectiveness of laser therapy can be greatly enhanced when photo-absorbing nanoparticles such as multi-walled carbon nanotubes (MWNTs) are introduced into the tissue [1,2]. The effectiveness of nanoparticle enhanced laser treatment can be determined through a combined approach using experimental measurement and computational models. This approach allows ideal laser parameters (e.g. irradiance, pulse duration) and nanoparticle properties (e.g. concentration and delivery method) to be selected to maximize treatment efficacy. We developed a computational model to predict the temperature response of tissue representative phantoms and in vivo murine renal cancer (RENCA) kidney tumors to MWNTs used in combination with external laser irradiation. The accuracy of the computational model prediction of temperature was verified by comparing with experimental measurements of temperature using magnetic resonance thermometry (MRTI). In addition, an image analysis technique is introduced for measuring the spatial viability of cancer cells suspended in tissue phantoms following nanoparticle enhanced laser therapy and correlating cell viability with thermal exposure. Spatial viability and thermal measurements are combined to predict cell death as a function of temperature in tissue phantoms.
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