Relevant bibliographies by topics / MRP4 (Multidrug Resistance Associated Protein 4)

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  1. Journal articles
  2. Dissertations / Theses
  3. Conference papers

Academic literature on the topic 'MRP4 (Multidrug Resistance Associated Protein 4)'

Author: Grafiati
Published: 8 June 2023

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Journal articles on the topic "MRP4 (Multidrug Resistance Associated Protein 4)"

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Steinbach, Daniel, Susann Wittig, Gunnar Cario, et al. "The multidrug resistance-associated protein 3 (MRP3) is associated with a poor outcome in childhood ALL and may account for the worse prognosis in male patients and T-cell immunophenotype." Blood 102, no. 13 (2003): 4493–98. http://dx.doi.org/10.1182/blood-2002-11-3461.

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Abstract The family of multidrug resistance-associated proteins (MRPs) belongs to the superfamily of adenosine triphosphate-binding-cassette (ABC) transporters, which have the ability to function as outward pumps for chemotherapeutic drugs and therefore might be involved in drug resistance. In this study the expression of the MRP2, MRP3, MRP4, MRP5, and SMRP genes was measured using TaqMan real-time polymerase chain reaction (PCR) in 103 children with previously untreated acute lymphoblastic leukemia (ALL) (precursor B-cell ALL [B-ALL], n = 71; T-cell ALL [T-ALL], n = 32). All 5 genes were exp
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Ansari, Marc, Geraldine Sauty, Albert Moghrabi, and Maja Krajinovic. "Polymorphisms in Multidrug Resistance-Associated Protein Genes Are Associated with Worse Outcome in Childhood Acute Lymphoblastic Leukemia." Blood 110, no. 11 (2007): 1443. http://dx.doi.org/10.1182/blood.v110.11.1443.1443.

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Abstract Methotrexate (MTX) is a key compound of chemotherapeutic regimens used in the treatment of childhood acute lymphoblastic leukemia (ALL). Inter-individual differences in response to this drug may cause treatment failures and adverse drug reactions. In particular, transporters of the adenosine triphosphate-binding cassette (ABC) family such as the ABCC (multidrug resistance-related protein, MRP) are involved in the efflux of this drug. The elimination of MTX may arise, among other factors, to be a major determinant of chemoresistance in leukemic blast cells. It has been demonstrated tha
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Donepudi, Ajay C., Gregory J. Smith, Oladimeji Aladelokun, et al. "Lack of Multidrug Resistance-associated Protein 4 Prolongs Partial Hepatectomy-induced Hepatic Steatosis." Toxicological Sciences 175, no. 2 (2020): 301–11. http://dx.doi.org/10.1093/toxsci/kfaa032.

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Abstract Multidrug resistance-associated protein 4 (Mrp4) is an efflux transporter involved in the active transport of several endogenous and exogenous chemicals. Previously, we have shown that hepatic Mrp4 expression increases following acetaminophen overdose. In mice, these increases in Mrp4 expression are observed specifically in hepatocytes undergoing active proliferation. From this, we hypothesized that Mrp4 plays a key role in hepatocyte proliferation and that lack of Mrp4 impedes liver regeneration following liver injury and/or tissue loss. To evaluate the role of Mrp4 in these processe
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Horvah, L. G., L. Ho, J. G. Kench, et al. "Elevated multidrug resistance-associated protein 4 (MRP4) expression in localized prostate cancer—A potential androgen regulated protein." Journal of Clinical Oncology 24, no. 18_suppl (2006): 20022. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.20022.

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20022 Background: MRP4 is an ATP-binding cassette transporter and amphipathic anion efflux pump which transports prostaglandins, nucleoside analogues, glutamate and phosphate analogues. High MRP4 expression is prognostic of poor outcome in neuroblastoma and also correlates with MYCN amplification, suggesting regulation by this oncogene. Although MRP4 is known to be expressed in normal prostate epithelium, its expression in prostate cancer (PC) is undefined. This study aimed to define the pattern of expression of MRP4 in normal and malignant prostate tissue and assess the association with andro
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Zhang, Jing, Ka-Yun Ng, and Paul C. Ho. "Interaction of Oxazaphosphorines with Multidrug Resistance-Associated Protein 4 (MRP4)." AAPS Journal 12, no. 3 (2010): 300–308. http://dx.doi.org/10.1208/s12248-010-9189-x.

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Hardwick, Rhiannon N., Marina Snellings, Brian C. Ferslew, Yang Lu, and Kim L. R. Browuer. "Tyrosine and aurora kinase inhibitors diminish transport function of multidrug resistance-associated protein (MRP) 4 and breast cancer resistance protein (BCRP)." ADMET and DMPK 4, no. 4 (2016): 302. http://dx.doi.org/10.5599/admet.4.4.322.

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<p class="PaperKeywordTitle">Tyrosine and aurora kinases are important effectors in signal transduction pathways that are often involved in aberrant cancer cell growth. Tyrosine (TKI) and aurora (AKI) kinase inhibitors are anti-cancer agents specifically designed to target such signaling pathways through TKI/AKI binding to the ATP-binding pocket of kinases thereby leading to diminished kinase activity. Some TKIs have been identified as inhibitors of ATP-binding cassette (ABC) transporters such as P-glycoprotein and breast cancer resistance protein (BCRP), which are commonly upregulated i
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Hayashi, Hisamitsu, Sotaro Naoi, Takayuki Nakagawa, et al. "Sorting Nexin 27 Interacts with Multidrug Resistance-associated Protein 4 (MRP4) and Mediates Internalization of MRP4." Journal of Biological Chemistry 287, no. 18 (2012): 15054–65. http://dx.doi.org/10.1074/jbc.m111.337931.

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Ansari, Marc, Géraldine Sauty, Malgorzata Labuda, et al. "Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia." Blood 114, no. 7 (2009): 1383–86. http://dx.doi.org/10.1182/blood-2008-11-191098.

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Abstract Methotrexate and 6-mercaptopurine, important components of acute lymphoblastic leukemia treatment, are substrates for multidrug resistance-associated protein MRP4. Eight single nucleotide polymorphisms were analyzed in MRP4 gene, and 4 variants were identified as tagSNPs with frequency more than or equal to 5%. They were investigated for association with treatment responses in 275 children with acute lymphoblastic leukemia. The TC genotype of the regulatory T-1393C polymorphism was associated with better event-free survival (P = .02) and lower methotrexate plasma levels (P = .01). The
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May, M., C. Alejandro, N. Gomez, et al. "P-020 Targeting multidrug resistance – associated protein 4 (MRP4/ABCC4) in pancreatic cancer." Annals of Oncology 27 (June 2016): ii6. http://dx.doi.org/10.1093/annonc/mdw199.20.

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Sassi, Y., S. El Haou, Y. Fromes, et al. "J016 Inhibition of the multidrug resistance-associated protein 4, MRP4 promotes cardiac hypertrophy." Archives of Cardiovascular Diseases 102 (March 2009): S108. http://dx.doi.org/10.1016/s1875-2136(09)72391-5.

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Dissertations / Theses on the topic "MRP4 (Multidrug Resistance Associated Protein 4)"

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Carillion, Aude. "Physiopathologie de la dysfonction bêta-adrénergique et rôle de la protéine MRP4 au cours du vieillissement, du diabète et du syndrome métabolique." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066485/document.

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Les travaux présentés dans ce mémoire ont pour objectif d’approfondir la compréhension de l’altération de la réponse à la stimulation des récepteurs β-adrénergiques dans plusieurs contextes physiopathologiques. La première étude confirme l’existence d’une dysfonction β-adrénergique à l’échelle du cardiomyocyte au cours de la sénescence. Elle met en lumière le rôle de la protéine MRP4 (multidrug resistance associated protein 4) dans cette diminution de réponse inotrope positive à l’isoprotérénol. La deuxième étude évalue la réponse à la stimulation des récepteurs β-adrénergiques dans le syndrom
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Lemaire, Laurine. "Étude des propriétés physico-chimiques de la membrane plasmique comme facteurs modulant l'interaction de molécules et des structures protéiques exogènes." Electronic Thesis or Diss., Compiègne, 2022. http://www.theses.fr/2022COMP2713.

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La membrane plasmique est souvent décrite comme une structure délimitant et protégeant la cellule de son environnement. Son rôle est bien plus complexe et multifonctionnel, c’est une plateforme d’échange et de contact incontournable entre les milieux externes et internes des cellules. De nombreuses fonctions cellulaires lui sont étroitement liées comme la migration, le transport de molécules, certaine voie de signalisation ou le contact avec des micro-organismes. Les travaux de cette thèse se focalisent sur l’étude de processus cellulaires s’orchestrant au niveau membranaire par un système mim
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Tan, Kah Poh. "Nuclear Factor (Erythroid 2-like) Factor 2 (Nrf2) as Cellular Protector in Bile Acid and Retinoid Toxicities." Thesis, 2008. http://hdl.handle.net/1807/17287.

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Exposure to toxic bile acids (BA) and retinoic acids (RA) is implicated in toxicities related to excessive oxidative stress. This thesis examined roles and mechanisms of the oxidative stress-responsive nuclear factor (erythroid 2-like) factor 2 (Nrf2) in adaptive cell defense against BA and RA toxicities. Using liver cells and mouse models, many antioxidant proteins known to be Nrf2 target genes, particularly the rate-limiting enzyme for glutathione (GSH) biosynthesis, i.e., glutamate-cysteine ligase subunits (GCLM/GCLC), were induced by BA [lithocholic acid (LCA)] or RA (all-trans, 9-cis an
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Conference papers on the topic "MRP4 (Multidrug Resistance Associated Protein 4)"

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Kochel, Tyler, Xinrong Ma, Namita Kundu, Jocelyn Reader, Olga Goloubeva, and Amy M. Fulton. "Abstract 4132: Multiple drug resistance-associated protein 4 (MRP4): Role in triple negative breast cancer." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4132.

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Leslie, Elaine M., Janet R. Zhou, and Gurnit Kaur. "Arsenic Hepatic Sinusoidal Export is Stimulated by Methylselenocysteine and Mediated by Multidrug Resistance Protein 4 (MRP4/ABCC4)." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.537850.

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Kochel, Tyler J., Namita Kundu, Xinrong Ma, Jocelyn Reader, and Amy Fulton. "Abstract 2257: Multiple drug resistance-associated protein 4 (MRP4) may contribute to breast cancer metastasis by exporting the COX-2 product PGE2." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2257.

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Kochel, Tyler J., Jocelyn Reader, Namita Kundu, et al. "Abstract 5119: Multiple drug resistance-associated protein 4 (MRP4) may contribute to breast cancer progression by exporting the COX-2 product PGE2." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5119.

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