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1

The craniocervical syndrome and MRI. Basel: Karger, 2015.

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2

Rajeev, S. G. Fluid Mechanics. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198805021.001.0001.

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Starting with a review of vector fields and their integral curves, the book presents the basic equations of the subject: Euler and Navier–Stokes. Some solutions are studied next: ideal flows using conformal transformations, viscous flows such as Couette and Stokes flow around a sphere, shocks in the Burgers equation. Prandtl’s boundary layer theory and the Blasius solution are presented. Rayleigh–Taylor instability is studied in analogy with the inverted pendulum, with a digression on Kapitza’s stabilization. The possibility of transients in a linearly stable system with a non-normal operator is studied using an example by Trefethen et al. The integrable models (KdV, Hasimoto’s vortex soliton) and their hamiltonian formalism are studied. Delving into deeper mathematics, geodesics on Lie groups are studied: first using the Lie algebra and then using Milnor’s approach to the curvature of the Lie group. Arnold’s deep idea that Euler’s equations are the geodesic equations on the diffeomorphism group is then explained and its curvature calculated. The next three chapters are an introduction to numerical methods: spectral methods based on Chebychev functions for ODEs, their application by Orszag to solve the Orr–Sommerfeld equation, finite difference methods for elementary PDEs, the Magnus formula and its application to geometric integrators for ODEs. Two appendices give an introduction to dynamical systems: Arnold’s cat map, homoclinic points, Smale’s horse shoe, Hausdorff dimension of the invariant set, Aref ’s example of chaotic advection. The last appendix introduces renormalization: Ising model on a Cayley tree and Feigenbaum’s theory of period doubling.
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3

Oikonomopoulou, Katerina, and Vinod Chandran. Biomarkers of psoriatic arthritis outcomes. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0022.

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Psoriatic arthritis is an inflammatory musculoskeletal disease that occurs in patients suffering from psoriasis. The disease manifests with symptoms affecting the skin, peripheral and axial joints, and periarticular structures. Diagnosis and management of psoriatic arthritis is challenging due to its heterogeneous presentation. However, early diagnosis and subsequent appropriate treatment reduces disease activity, prevents joint damage, and improves long-term outcome. It is hoped that biomarkers for disease progression and activity will aid in cost-effective clinical management of patients. Potential biomarkers under investigation for psoriatic arthritis are disease-related components derived from skin and articular tissues, biological fluids, such as blood and synovial fluid, and arthritis-associated cell populations. Imaging including ultrasound and MRI are also being evaluated as biomarkers for diagnosis, activity and outcome. Despite the challenge of bringing these new markers into the clinic, many of these markers hold promise for the future management of patients with psoriatic arthritis.
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4

Keshav, Satish, and Palak Trivedi. Investigation in liver disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0208.

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This chapter discusses investigations in liver disease, including blood tests (liver chemistry and liver function tests, alpha-fetoprotein, viral serology, antibodies and immunoglobulins), ascetic fluid analysis, imaging (hepatobiliary ultrasound, CT, MRI, endoscopic ultrasound), and liver biopsy.
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5

Wood Ranch thermal anomaly, Iron County, Utah : self-potential survey and fluid chemistry. Utah Geological Survey, 1991. http://dx.doi.org/10.34191/mp-91-4.

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6

Klimo, Paul, and Nir Shimony. Ependymomas. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0026.

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Pediatric posterior fossa tumors are usually ependymoma, pilocytic astrocytoma, or medulloblastoma. Ependymoma appears well-demarcated with heterogeneous enhancement on magnetic resonance imaging (MRI). Full neural axis MRI is indicated to assess for metastatic disease. Management is typically surgical resection of the tumor, with consideration for cerebrospinal fluid diversion if patients present with severe hydrocephalus. Extent of resection of the tumor is the most important factor in predicting recurrence and overall survival, and gross total resection is ideal. Infratentorial ependymomas have 2 molecular subtypes, which has implications for responsiveness to adjuvant therapy and prognosis. Infratentorial ependymomas are biologically different from supratentorial ependymomas. Postoperative radiation improves local control.
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7

Chappell, Michael, Bradley MacIntosh, and Thomas Okell. Partial Volume Effects. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198793816.003.0006.

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Partial volume effects are present in all medical imaging methods, and they play a specific role in arterial spin labeling (ASL) MRI measurements of perfusion. This chapter demonstrates how differences in the perfusion properties of gray matter, white matter, and cerebrospinal fluid give rise to the distinctive visual appearance of cerebral perfusion images. The implications of this for quantification of perfusion in gray matter are discussed and solutions to correct for partial volume effects presented.
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8

Bates, David. Brainstem syndromes. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199204854.003.02409_update_001.

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Case History—A 78 yr old woman presenting with brainstem signs following a seizure.Brainstem syndromes typically cause ipsilateral cranial nerve lesions and contralateral long tract signs. They are commonly due to brainstem ischaemia, but can also be caused by neoplasia, demyelination, infective and hamartomatous lesions. Imaging, ideally with MRI rather than CT, is obligatory and only then—and possibly following other investigations to identify systemic abnormality or cerebrospinal fluid changes—can appropriate therapy be introduced....
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9

Flanagan, Eoin P., and Richard J. Caselli. Other Proven and Putative Autoimmune Disorders of the CNS. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0093.

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The historical term “Hashimoto’s encephalopathy” describes a serologically diverse spectrum of autoimmune encephalopathies that tend to be highly steroid responsive and unassociated with cancer. Patients typically present with subacute cognitive decline and serological evidence of autoimmunity that includes but is not limited to thyroid antibodies. An inflammatory spinal fluid and, in a subset of patients, MRI signal abnormalities are supportive. Patients often respond promptly to corticosteroids but relapses are typical. The continued discovery of novel neural-specific-autoantibodies such as voltage-gated-potassium-channel-autoantibodies associated with autoimmune encephalopathies highlights why the term “Hashimoto’s” is misleading. The authors advocate the more general term “autoimmune encephalopathy.”
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10

Sedel, Frédéric. Krabbe Disease in Adults. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0051.

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Krabbe disease (globoid cell leukodystrophy) is an autosomal recessive lysosomal storage disease caused by mutations in the lysosomal galactocerebrosidase (galactosyl ceramidase) gene. Krabbe disease usually presents as a severe leukodystrophy in early infancy and childhood. In contrast, adult patients usually present with progressive spastic paraparesis. Other signs of the disease include peripheral neuropathy, dysarthria, cerebellar ataxia, pes cavus deep sensory signs, tongue atrophy, optic neuropathy, cognitive decline. Cerebrospinal fluid protein concentration is moderately increased in adults. High signals of cortico-spinal tracts on brain MRI are highly suggestive and this typical aspect may be associated with hyper-intensities of optic radiations, and of the posterior part of the corpus callosum.
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11

Thaggert, Miriam, and Rachel Farebrother, eds. African American Literature in Transition, 1920–1930. Cambridge University Press, 2022. http://dx.doi.org/10.1017/9781108992039.

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African American Literature in Transition, 1920-1930 presents original essays that map ideological, historical, and cultural shifts in the 1920s. Complicating the familiar reading of the 1920s as a decade that began with a spectacular boom and ended with disillusionment and bust, the collection explores the range and diversity of Black cultural production. Emphasizing a generative contrast between the ephemeral qualities of periodicals, clothes, and décor and the relative fixity of canonical texts, this volume captures in its dynamics a cultural movement that was fluid and expansive. Chapters by leading scholars are grouped into four sections: 'Habitus, Sound, Fashion'; 'Spaces: Chronicles of Harlem and Beyond'; 'Uplift Renewed: Religion, Protest, and Education,' and 'Serial Reading: Magazines and Periodical Culture.'
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12

Cheillan, David, and Frédéric Sedel. Disorders of Creatine Metabolism. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0010.

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Creatine is a physiological guanidino compound playing a major role in energy metabolism in muscle and implicated in neurotransmission in brain. The three disorders of creatine metabolism (AGAT and GAMT deficiencies and the X-linked creatine transporter defect) are a group of inborn errors of metabolism characterized by a depletion of creatine that could be easily diagnosed by mesasurement of guanidinoacetate and creatine in body fluid or cranial MRS spectroscopy. The main clinical features of these paediatric disorders are intellectual disability and speech delay and some adult patients have been described with severe language impairment and mental retardation. Although the X-linked creatine transporter defect is currently not treatable, the clinical symptoms of the two disorders of creatine synthesis should be improved by creatine supplementation emphasizing the importance of an early diagnostic.
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13

Sturman, Rob, Julio M. Ottino, and Stephen Wiggins. Mathematical Foundations of Mixing : The Linked Twist Map As a Paradigm in Applications: Micro to Macro, Fluids to Solids. Cambridge University Press, 2006.

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14

Sturman, Rob, Julio M. Ottino, and Stephen Wiggins. Mathematical Foundations of Mixing : The Linked Twist Map As a Paradigm in Applications: Micro to Macro, Fluids to Solids. Cambridge University Press, 2006.

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15

Sturman, Rob, Julio M. Ottino, and Stephen Wiggins. Mathematical Foundations of Mixing : The Linked Twist Map as a Paradigm in Applications: Micro to Macro, Fluids to Solids. Cambridge University Press, 2010.

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16

Sturman, Rob, Stephen Wiggins, and J. M. Ottino. Mathematical Foundations of Mixing : The Linked Twist Map As a Paradigm in Applications: Micro to Macro, Fluids to Solids. Cambridge University Press, 2006.

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17

Sturman, Rob, Julio M. Ottino, and Stephen Wiggins. Mathematical Foundations of Mixing: The Linked Twist Map as a Paradigm in Applications - Micro to Macro, Fluids to Solids. Cambridge University Press, 2006.

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18

McCartney, Mark, Andrew Whitaker, and Alastair Wood, eds. George Gabriel Stokes. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198822868.001.0001.

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George Gabriel Stokes was one of the most significant mathematicians and natural philosophers of the nineteenth century. Serving as Lucasian professor at Cambridge he made wide-ranging contributions to optics, fluid dynamics and mathematical analysis. As Secretary of the Royal Society he played a major role in the direction of British science acting as both a sounding board and a gatekeeper. Outside his own area he was a distinguished public servant and MP for Cambridge University. He was keenly interested in the relation between science and religion and wrote extensively on the matter. This edited collection of essays brings together experts in mathematics, physics and the history of science to cover the many facets of Stokes’s life in a scholarly but accessible way.
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19

Chadwick, David, Alastair Compston, Michael Donaghy, Nicholas Fletcher, Robert Grant, David Hilton-Jones, Martin Rossor, Peter Rothwell, and Neil Scolding. Investigations. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569381.003.0100.

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This chapter describes the many methods that can be used to investigate neurological disorders. The application and suitability for specific disorder types are outlined, as are contraindications for use. Methods of imaging the central nervous system include computed tomography (CT) imaging, several magnetic resonance (MR) scanning methods, Single photon emission computed tomography (SPECT) and Positron Emission Tomography (PET). Invasive (angiography) and non-invasive methods of imaging the cerebral circulation are also outlined.The standard method of recording electrical activity of the brain is the electroencephalogram (EEG), which is heavily used in epilepsy to investigate regions of epileptogenesis.Other investigations described include evoked potentials, nerve conduction and electromyography studies, the examination of cerebrospinal fluid and the diagnostic use of neurological autoantibodies. Finally, neurogenetics, neuropsychological assessment and the assessment of treatments by randomized trials are discussed.
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20

Bates, David. Spinal cord disorders. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569381.003.0650.

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Non-traumatic spinal cord disease may be caused by compression due to tumour, infection or haematoma, inflammation, infection or post-infection, metabolic disturbances, infarction, and degeneration. The diagnosis is often made easier by the clinical assessment: the patient’s age, the speed of onset of the disease, severity of the deficits, the pattern of motor and sensory involvement, and presence of pain and sphincter symptoms are all important in making an assessment of the site and likely nature of the spinal disease.Investigations are obligatory to confirm a diagnosis and to direct therapy. MRI is the most useful investigation. It has largely replaced myelography which should now only be considered in patients with indwelling cardiac pacing wires. Additional investigations including examination of the cerebrospinal fluid, evoked potentials, and specific blood tests may be required and the value of plain X-rays, CT scan, and, in some instances, angiography should not be overlooked.The remainder of this chapter will consider specific disorders, identifying pathology, clinical presentation, investigation, and management. Acute and chronic conditions are considered separately and those affecting the cauda equina, spinal root, and sphincters are considered in Chapter 29.
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21

Sturman, Rob, Julio M. Ottino, and Stephen Wiggins. The Mathematical Foundations of Mixing: The Linked Twist Map as a Paradigm in Applications: Micro to Macro, Fluids to Solids (Cambridge Monographs on Applied and Computational Mathematics). Cambridge University Press, 2006.

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22

Bleck, Thomas P. Assessment and management of seizures in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0232.

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In previously conscious patients seizures are usually easily detected. Critically-ill patients are frequently sedated and a proportion are paralysed with neuromuscular blocking agents, in such patients it may be hard or impossible to detect seizures clinically. An urgent electroencephalogram (EEG) should be obtained whenever seizures are witness or suspected, especially if the patient does not rapidly return to baseline, when non-convulsive status epilepticus must be excluded. Unless the cause of the seizure activity is already known, an urgent CT, or MRI is indicated. If central nervous system infection is suspected a lumbar puncture may be needed. Status epilepticus is diagnosed when there is recurrent or continued seizure activity without intervening recovery. Most seizures are self-limiting and stop after 1–2 minutes, seizures that continue for more than 5 minutes should be treated. Treatment priorities for any seizure are to stop the patient hurting either themselves or anyone else. General supportive measures include attention to the airway, breathing, circulation, exclusion of hypoglycaemia and an EEG to exclude non-convulsive status epilepticus. A variety of drugs can be used to terminate seizures; parenteral benzodiazepines are the most commonly used agents although propofol and barbiturates are alternatives. Emergent endotracheal intubation may well be necessary, hypotension can be expected and may need treatment with intravenous fluids and vasopressors.
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