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Author: Grafiati

Published: 4 June 2021

Last updated: 26 April 2022

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1

Dai, Yan-Shan, Jian Xu, and Jeffery D. Molkentin. "The DnaJ-Related Factor Mrj Interacts with Nuclear Factor of Activated T Cells c3 and Mediates Transcriptional Repression through Class II Histone Deacetylase Recruitment." Molecular and Cellular Biology 25, no. 22 (November 15, 2005): 9936–48. http://dx.doi.org/10.1128/mcb.25.22.9936-9948.2005.

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ABSTRACT The calcium-regulated protein phosphatase calcineurin (PP2B) functions as a regulator of gene expression in diverse tissues through the dephosphorylation and activation of a family of transcription factors known as nuclear factor of activated T cells (NFAT). Here we show that NFATc3, in addition to being calcium responsive, is regulated through an indirect recruitment of class II histone deacetylases (HDACs). Specifically, yeast two-hybrid screening with the rel homology domain of NFATc3 identified the chaperone mammalian relative of DnaJ (Mrj) as a specific interacting factor. Mrj and NFATc3 were shown to directly associate with one another in mammalian cells and in vitro. Mrj served as a potent inhibitor of NFAT transcriptional activity within the nucleus through a mechanism involving histone deacetylase recruitment in conjunction with heat shock stimulation. Indeed, Mrj was determined to interact with class II histone deacetylases, each of which translocated to the nucleus following heat shock stimulation. Mrj also decreased NFATc3 occupancy of the tumor necrosis factor-α promoter in cardiomyocytes in an HDAC-dependent manner, and Mrj blocked calcineurin-induced cardiomyocyte hypertrophic growth. Conversely, small-interfering-RNA-mediated reduction of Mrj augmented NFAT transcriptional activity and spontaneously induced cardiac myocyte growth. Collectively, our results define a novel response pathway whereby NFATc3 is negatively regulated by class II histone deacetylases through the DnaJ (heat shock protein-40) superfamily member Mrj.

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Salazar, Bianca Alves, Mônica Rodrigues Campos, and Vera Lucia Luiza. "A Carteira de Serviços de Saúde do Município do Rio de Janeiro e as ações em saúde na Atenção Primária no Brasil." Ciência & Saúde Coletiva 22, no. 3 (March 2017): 783–96. http://dx.doi.org/10.1590/1413-81232017223.33442016.

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Resumo Objetivou-se identificar a oferta de ações e procedimentos pelas equipes de saúde da família (eSF), tendo por base a Carteira de Serviços (CS) do Município do Rio de Janeiro (MRJ) e os principais fatores associados a esta oferta, nos diferentes estratos populacionais. Foram utilizados dados do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica, aplicado a 17.202 eSF, de junho a setembro de 2012 no Brasil. Foram variáveis desfecho: eSF pertencer ao MRJ; eSF ofertar todos os nove procedimentos da CS-MRJ. Foram conduzidas análises uni, bi e multivariada. Evidenciou-se melhor desempenho do MRJ em relação aos demais grandes centros urbanos (EP6#) (p < 5%) em 10 das 14 ações de saúde analisadas. O prontuário eletrônico apresentou 96% de implantação nas eSF do MRJ, contrastando com 34% nas dos EP6# e 14% no Brasil. Tanto no MRJ quanto no EP6# encontrou-se baixa oferta de serviços de saúde mental (cerca de 56%). Enquanto a oferta de procedimentos de baixa complexidade foi um problema maior nos grandes centros, a oferta de ações em saúde nas diferentes linhas de cuidado foi um problema maior nos municípios pequenos. No geral, o MRJ mostrou melhor desempenho quando comparado à média de municípios de grande porte. A carteira de serviço pareceu ser um importante instrumento gerencial.

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DEB, BISWAJIT, KALPESH KAPOOR, and SUKANTA PATI. "ON mRJ REACHABILITY IN TREES." Discrete Mathematics, Algorithms and Applications 04, no. 04 (December 2012): 1250055. http://dx.doi.org/10.1142/s1793830912500553.

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Given a tree T, a configuration of T is denoted by [Formula: see text] which represents that there is a robot at the vertex u, a hole at the vertex v and obstacles in the remaining vertices of T. By an mRJ move we mean that the robot is moved from the vertex u to a vertex v having a hole by jumping over m obstacles along a path. The case m = 0 is a simple move of taking the robot from u to the adjacent vertex v with a hole. We investigate the problem of moving a robot from its initial position to all the other vertices using mRJ moves (for some fixed m) in addition to simple moves. A tree is said to be mRJ reachable if there exists a configuration from which it is possible to take the robot to any vertex of the tree using simple or mRJ moves. A connected graph is 1RJ reachable. However, for m ≥ 2 there exists graphs that are not mRJ reachable. We characterize 2RJ and 3RJ reachable trees and give bound for the diameter of mRJ reachable trees.

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Oshima, K., T. Kojima, H. Watanabe, M. Fukushima, O. Dochi, N. Takenouchi, M. Komatsu, and N. Yamamoto. "247GENE EXPRESSION OF MAMMALIAN RELATIVE OF DNAJ IN BOVINE ENDOMETRIUM DURING EARLY PREGNANCY." Reproduction, Fertility and Development 16, no. 2 (2004): 244. http://dx.doi.org/10.1071/rdv16n1ab247.

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The mammalian relative of DNAJ (MRJ), a member of the molecular chaperones that are known as heat shock proteins, plays an important role in the process of murine chorioallantoic fusion. The objective of this study was to determine the expression pattern of MRJ in the bovine endometrium during early and mid-pregnancy using quantitative RT-PCR. Twenty-eight Japanese Black cows, aged between 1.2 and 15.2 years, with normal estrous cycles, were used in this study. Twenty-one cows were used for study of the level of MRJ during pregnancy. They were artificially inseminated, and their endometrial tissues were collected on Days 16 to 21 (n=7), 30 to 36 (n=6), 48 to 49 (n=4) and 74 to 140 (n=4) of pregnancy. Seven cows were used as controls for the study of cyclic level of MRJ, and their endometrial tissues were collected on Days 13 to 14 (n=4) and 17 to 20 (n=3) of the estrous cycle. The caruncles and the intercaruncles were isolated from the endometrial tissues. All tissues were frozen immediately using liquid nitrogen. Total RNA from these samples was extracted from the tissue using Trizol (Invitrogen Corp., Carlsbad, CA, USA). The first strand of cDNA was synthesized from the total RNA by oligo (dT)12–18 and SuperScript™ II RNase H- Reverse Transcriptase (Invitrogen Corp.) according to the manufacturer’s instructions. Primers and the TaqMan probe for MRJ and glyceraldehyde-phosphate-dehydrogenase (GAPDH) were designed using the primer design software Primer Express™ (Applied Biosystems, Foster City, CA, USA). Bovine GAPDH was used as an internal standard. All PCR reactions were performed using a TaqMan™ PCR Reagent Kit and a MicroAmp Optical 96-Well Reaction Plate and Cap (Applied Biosystems). The assay used an ABI Prism 7700 Sequence Detector (Applied Biosystems). Signals were detected according to the manufacturer’s instructions. The relative level of MRJ expression was calculated on the basis of GAPDH quantity (the method of calculation: relative level=MRJ quantity/GAPDH quantity). Data were analyzed by one-way ANOVA, and means were conpared by Tukey-Kramer’s HSD test. Mammalian relative of DNAJ genes were expressed in all samples examined;; the levels in intercaruncle tended to be greater than those in caruncle. Although MRJ expression level at Days 16 to 21 of pregnancy was greater than at other days during pregnancy, there were no significant differences between the levels at Days 16 to 21 of pregnancy and those of the estrous cycle. These results suggest that MRJ is produced in the endometrium and may play a role in early and mid-pregnancy and the estrous cycle.

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Zhou, Yuan Qi, and Liang Yan. "A Jump Diffusion Model for Evaluating of an Oilfield Development Project and its Application." Advanced Materials Research 616-618 (December 2012): 1563–67. http://dx.doi.org/10.4028/www.scientific.net/amr.616-618.1563.

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Irreversible investments with largest outlay made with incomplete information are the mainstay of the oilfield development. Real Options Analysis (ROA) is a useful tool for making investment decisions under market uncertainty. Normal information generates continuous mean-reverting process for oil prices, whereas random abnormal information generates discrete jumps of random size. We will evaluate an oilfield development project using Mean-Reversion with Jumps (MRJ). As an example, we compare MRJ and Geometric Brownian Motion (GBM )valuation for the timing of investment and the optimization problem. This article concludes MRJ in some cases can induce better corporate decisions than GBM.

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Zhou, Yuan Qi, and Liang Yan. "Comparing Two Models for Evaluating an Oilfield Development Project: Mean-Reversion with Jumps, Geometric Brownian Motion." Advanced Materials Research 616-618 (December 2012): 1568–72. http://dx.doi.org/10.4028/www.scientific.net/amr.616-618.1568.

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With incomplete information, the oilfield development is a high-risk venture and requires the largest outlay which is not Irreversible. Real Options Analysis (ROA) is a useful tool for making investment decisions under market uncertainty. We evaluate an oilfield development project using Mean-Reversion with Jumps (MRJ) and Geometric Brownian Motion (GBM). As an example, we compare GBM and MRJ valuation for the timing of investment and the optimization problem. Furthermore, we investigate the impact of different parameters of the two stochastic oil price models. This article concludes MRJ has a better risk management ability than GBM has, especially in a higher market oil price of risk.

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Mahmood, Abid, Tanvir Shahzad, Sabir Hussain, Qasim Ali, Hayssam M. Ali, Sanaullah Yasin, Muhammad Ibrahim, Mohamed Z. M. Salem, and Muhammad Khalid. "Evaluation of Symbiotic Association between Various Rhizobia, Capable of Producing Plant-Growth-Promoting Biomolecules, and Mung Bean for Sustainable Production." Sustainability 13, no. 24 (December 14, 2021): 13832. http://dx.doi.org/10.3390/su132413832.

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To feed the increased world population, sustainability in the production of crops is the need of the hour, and exploration of an effective symbiotic association of rhizobia with legumes may serve the purpose. A laboratory-scale experiment was conducted to evaluate the symbiotic effectiveness of twenty wild rhizobial isolates (MR1–MR20) on the growth, physiology, biochemical traits, and nodulation of mung bean to predict better crop production with higher yields. Rhizobial strain MR4 resulted in a 52% increase in shoot length and 49% increase in shoot fresh mass, while MR5 showed a 30% increase in root length, with 67% and 65% improvement in root fresh mass by MR4 and MR5, respectively, compared to uninoculated control. Total dry matter of mung bean was enhanced by 73% and 68% with strains MR4 and MR5 followed by MR1 and MR3 with 60% increase in comparison to control. Rhizobial strain MR5 produced a maximum (25 nodules) number of nodules followed by MR4, MR3, and MR1 which produced 24, 23, and 21 nodules per plant. Results related to physiological parameters showed the best performance of MR4 and MR5 compared to control among all treatments. MR4 strain helped the plants to produce the lowest values of total soluble protein (TSP) (38% less), flavonoids contents (44% less), and malondialdehyde (MDA) contents (52% less) among all treatments compared to uninoculated control plants. Total phenolics contents of mung bean plants also showed significantly variable results, with the highest value of 54.79 mg kg−1 in MR4 inoculated plants, followed by MR5 and MR1 inoculated plants, while the minimum concentration of total phenolics was recorded in uninoculated control plants of mung bean. Based on the results of growth promotion, nodulation ability, and physiological and biochemical characteristics recorded in an experimental trial conducted under gnotobiotic conditions, four rhizobial isolates (MR1, MR3, MR4, and MR5) were selected using cluster and principal component analysis. Selected strains were also tested for a variety of plant-growth-promoting molecules to develop a correlation with the results of plant-based parameters, and it was concluded that these wild rhizobial strains were effective in improving sustainable production of mung bean.

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Urban, Boris, and Jabulile Galawe. "The mediating effect of self-efficacy on the relationship between moral judgement, empathy and social opportunity recognition in South Africa." International Journal of Entrepreneurial Behavior & Research 26, no. 2 (November 13, 2019): 349–72. http://dx.doi.org/10.1108/ijebr-05-2019-0271.

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Purpose Scholars researching entrepreneurship argue that the distinct characteristics of social entrepreneurs, together with the particular category of opportunities they pursue, invite us to further understand social entrepreneurship (SE) as a distinct field of investigation. The purpose of this paper is to investigate opportunity recognition behaviour of social entrepreneurs and closely related unique attributes of empathy, moral judgement (MRJ) and self-efficacy, in an emerging market African context. Design/methodology/approach A survey was administered to social entrepreneurs across two of the largest provinces in South Africa, namely Cape Town and Gauteng. Hypotheses were statistically tested using correlational analysis and hierarchical regression with mediation effects. Findings Results reveal that social entrepreneurial self-efficacy (ESE) plays a significant mediating effect in the relationship between MRJ and social opportunity recognition. Moreover, perceived MRJ and social ESE act as important determinants of increased social opportunity recognition. Originality/value This study has brought to attention the relevance of opportunity recognition to social entrepreneurs, while recognising their distinctive features in terms of empathy and MRJ. While self-efficacy and opportunity recognition are relatively well established in the traditional entrepreneurship literature, this study extends the reach of these variables into the SE domain.

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Hunter, P. J., B. J. Swanson, M. A. Haendel, G. E. Lyons, and J. C. Cross. "Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development." Development 126, no. 6 (March 15, 1999): 1247–58. http://dx.doi.org/10.1242/dev.126.6.1247.

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We have identified a novel gene in a gene trap screen that encodes a protein related to the DnaJ co-chaperone in E. coli. The gene, named Mrj (mammalian relative of DnaJ) was expressed throughout development in both the embryo and placenta. Within the placenta, expression was particularly high in trophoblast giant cells but moderate levels were also observed in trophoblast cells of the chorion at embryonic day 8.5, and later in the labyrinth which arises from the attachment of the chorion to the allantois (a process called chorioallantoic fusion). Insertion of the ROSAbetageo gene trap vector into the Mrj gene created a null allele. Homozygous Mrj mutants died at mid-gestation due to a failure of chorioallantoic fusion at embryonic day 8.5, which precluded formation of the mature placenta. At embryonic day 8.5, the chorion in mutants was morphologically normal and expressed the cell adhesion molecule beta4 integrin that is known to be required for chorioallantoic fusion. However, expression of the chorionic trophoblast-specific transcription factor genes Err2 and Gcm1 was significantly reduced. The mutants showed no abnormal phenotypes in other trophoblast cell types or in the embryo proper. This study indicates a previously unsuspected role for chaperone proteins in placental development and represents the first genetic analysis of DnaJ-related protein function in higher eukaryotes. Based on a survey of EST databases representing different mouse tissues and embryonic stages, there are 40 or more DnaJ-related genes in mammals. In addition to Mrj, at least two of these genes are also expressed in the developing mouse placenta. The specificity of the developmental defect in Mrj mutants suggests that each of these genes may have unique tissue and cellular activities.

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Miyamura, Koichi, Masahide Osaki, Tatsunori Goto, Takanobu Morishita, and Yukiyasu Ozawa. "Optimal Interval for Detection of Molecular Relapse after Stop of Tyrosine Kinase Inhibitor (TKI) in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL) Caliculated By Kinetics of BCR-ABL Transcripts." Blood 136, Supplement 1 (November 5, 2020): 21. http://dx.doi.org/10.1182/blood-2020-141480.

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Background In Ph+ALL patients, prophylactic/maintenance administrations of TKI are used after the protocol treatment. Unlike Chronic myelogenous leukemia (CML), after TKI stopped, there is no consensus about how often to monitor to detect molecular relapse. In the current study, from clinical data of 31 patients we tried to determine the optimal frequency of MRD monitor for better prognosis using a mathematical model. Methods Doubling time (DT) and Growth rate (GR) were retrospectively calculated by the increase of BCR-ABL from 99 kinetic data from 31 patients with Ph+ALL at molecular relapse. Measurement of amount BCR-ABL was performed by RQ-PCR. Mimicking CML, we defined BCR-ABL/ABL ratio of 0.1% as "MR3 (Major molecular response)" and undetectable levels of BCR-ABL transcript as "MR5 (Complete molecular response)". In order to investigate the relationship between tumor burden (BCR/ABL) at the time of MRD detection and prognosis, it was divided into 3 groups, BCR/ABL<0.1% (MR3), 0.1%<BCR/ABL<1% (MR2) and BCR/ABL>1% (MR1). This study was approved by the institutional review committee. Results The doubling time was 1.3 days (GR 0.7%/day) to 95.4 days (70.8%/day) with a median of 12.3 days (5.8%). The rate of increase was compared by three groups of tumor burden. The DT among patients in MR1 was shorter than those in MR3 and MR2 (7.7 days vs 15.2 days in median, t-test p<0.01). There were no differences of DT in sex, age, treatments and BCR/ABL mutation. Most patient had multiple kinetic data and the smallest amount of BCR/ABL was used in each patient. Among 8 patients who showed MR3 (MR3pt) and 11 who showed MR2 (MR2pt), 14 are alive at this analysis, while among 10 patients who showed MR1 (MR1pt), only 1 patient is alive.(Log-rank test, p<0.1) (Figure) Median survival time is 882 days, 330 days and 16 days in MR3pt, Mr2pt and MR1pt, respectively. All patients died of progression of the disease. Finding molecular relapse before MR2 may related to better results. Optimal interval of MRD detection We set several hypotheses to determine the optimal frequency to detect early recurrence of leukemia. We estimated that patients with MR2 and MR5 have 1010 and 107 Ph+ cells in body, respectively. We defined "MR2" and "MR5" as "optimal intervention threshold" and "detection threshold". From our clinical data, we tentatively determined that doubling time of leukemia growth is distributed between 1 day (GR 100%/day) and 100days (0.7%). Also, we assumed that single cell has a relapse potency and the GR is constant during observation in each patient. The number of Ph+ cells in a MR5 patient who would potentially relapse might be distributed between 1 cell and 1 x 107 (MR5). "Success" was defined as if molecular relapse is detected between M5 and MR2 and "Failure" was defined as if detected more than MR2. According to the daily clinical practice, the optimal examination interval is tentatively every 7 days, every 14 days, every 28 days, every 56 days, every 84 days, every 6 months, and every year. First, in order to calculate the growth rate that would be successful at 7-day intervals, the rate of 168%/day for 1 cell to increase 107 (MR5) in 7 days was calculated. This rate is faster than the maximum rate of 100%/day in this study, so an interval of 7 days is good for the initial period. Similarly, at 14-day intervals, 68%/day is calculated, and in this case, it requires 32 days to increase 107 (MR5) from 1 cell. As a result, after 32.7 days, 14-day intervals are acceptable. Similarly, the calculated results for 28 days, 56 days, 84 days, 6 months, and 1 year are shown in the Table. MRD can be found before M3 (success) with 28-day intervals after 65 days, 56-day intervals after 131 days, 84-day intervals after 196 days, 6-month intervals after 419 days and 1-year intervals after 852 days. Conclusion Taken together, soon after stop of TKI, more frequent monitoring of MRD than in "treatment free remission" in CML is needed. The interval can be prolonged with the passage of time. In several patients, hematopoietic stem cell transplantation (HSCT) was possible due to early intervention by changing TKI and chemotherapy. After HSCT, TKI combined with rapid reduction of immune-suppressants and donor lymphocyte infusion successfully related with long term survival. (data will be shown in ASH) Thus, the tight monitoring according to the mathematical model is important. The current strategy may be applied to other leukemia in which MRD monitoring by PCR is established. Disclosures Miyamura: Bristol-Myers Squibb Co., Ltd.:Honoraria;Celgene Co., Ltd.:Honoraria;Daiichi-Sankyo Co., Ltd.:Honoraria;Otsuka Co., Ltd.:Honoraria;Pfizer Co., Ltd.:Honoraria;Novartis Co., Ltd.:Honoraria.Goto:Takeda Pharmaceutical Co., Ltd:Honoraria;Novartis Pharma Co., Ltd.:Honoraria.Morishita:Bristol-Myers Squibb Co., Ltd.:Honoraria.Ozawa:Novartis Co., Ltd.:Honoraria.

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Aron, D. N., T. L. Foutz, S. A. Thompson, and U. Rytz. "Mechanical Evaluation of Soft Cast (Scotchcast, 3M) and Conventional Rigid and Semi-rigid Coaptation Methods." Veterinary and Comparative Orthopaedics and Traumatology 09, no. 01 (1996): 14–21. http://dx.doi.org/10.1055/s-0038-1632496.

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SummaryA clinically relevant model was created to mechanically evaluate different rigid and semi-rigid coaptation methods. Modulus of elasticity, yield stress, resilience and stiffness was measured to describe material strength and structure stiffness. Rigid Vetcast Plus, 3 M (VCP), new semi-rigid Softcast Scotchcast, 3 M (SC), conventional semi-rigid fibreglass slab reinforced modified Rober t Jone s (SMRJ ) bandages, and modified Robert Jones (MRJ ) bandages were tested with different thicknesses or configurations. Rigid (VCP) was the strongest and stiffest coaptation method. The reason for this was a strong bond between fibres and resin and between layers. New semi-rigid (SC) was the strongest of the semi-rigid coaptation methods followed by (SMRJ ) bandages and (MRJ ) bandages. With semi-rigid (SC) imperfections and voids in bond allowed some shear movement between fibres and resin and between layers giving cylindrical structures some resilience. Stiffness of semi-rigid (SMRJ ) was influenced by the position of the slab relative to the bending plane. Compressed cotton with semi-rigid (MRJ ) had very limited resistance to a bending force.New semi-rigid Softcast Scotch-cat, 3M (SC) was mechanically evaluated in an in vitro external coaptation model and compared to rigid Vetcast Plus, 3M (VCP), semi-rigid fibreglass slab reinforced modified Robert Jones (SMRJ) bandages, and modified Robert Jones (MRJ) bandages. Vetcast Plus (VCP) was overall the strongest, Scotchcast (SC) was the strongest of the semi-rigid coaptation methods.

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Yang, Joseph Yuan-Mou, Richard Beare, Marc L. Seal, A. Simon Harvey, Vicki A. Anderson, and Wirginia J. Maixner. "A systematic evaluation of intraoperative white matter tract shift in pediatric epilepsy surgery using high-field MRI and probabilistic high angular resolution diffusion imaging tractography." Journal of Neurosurgery: Pediatrics 19, no. 5 (May 2017): 592–605. http://dx.doi.org/10.3171/2016.11.peds16312.

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OBJECTIVECharacterization of intraoperative white matter tract (WMT) shift has the potential to compensate for neuronavigation inaccuracies using preoperative brain imaging. This study aimed to quantify and characterize intraoperative WMT shift from the global hemispheric to the regional tract-based scale and to investigate the impact of intraoperative factors (IOFs).METHODSHigh angular resolution diffusion imaging (HARDI) diffusion-weighted data were acquired over 5 consecutive perioperative time points (MR1 to MR5) in 16 epilepsy patients (8 male; mean age 9.8 years, range 3.8–15.8 years) using diagnostic and intraoperative 3-T MRI scanners. MR1 was the preoperative planning scan. MR2 was the first intraoperative scan acquired with the patient's head fixed in the surgical position. MR3 was the second intraoperative scan acquired following craniotomy and durotomy, prior to lesion resection. MR4 was the last intraoperative scan acquired following lesion resection, prior to wound closure. MR5 was a postoperative scan acquired at the 3-month follow-up visit. Ten association WMT/WMT segments and 1 projection WMT were generated via a probabilistic tractography algorithm from each MRI scan. Image registration was performed through pairwise MRI alignments using the skull segmentation. The MR1 and MR2 pairing represented the first surgical stage. The MR2 and MR3 pairing represented the second surgical stage. The MR3 and MR4 (or MR5) pairing represented the third surgical stage. The WMT shift was quantified by measuring displacements between a pair of WMT centerlines. Linear mixed-effects regression analyses were carried out for 6 IOFs: head rotation, craniotomy size, durotomy size, resected lesion volume, presence of brain edema, and CSF loss via ventricular penetration.RESULTSThe average WMT shift in the operative hemisphere was 2.37 mm (range 1.92–3.03 mm) during the first surgical stage, 2.19 mm (range 1.90–3.65 mm) during the second surgical stage, and 2.92 mm (range 2.19–4.32 mm) during the third surgical stage. Greater WMT shift occurred in the operative than the nonoperative hemisphere, in the WMTs adjacent to the surgical lesion rather than those remote to it, and in the superficial rather than the deep segment of the pyramidal tract. Durotomy size and resection size were significant, independent IOFs affecting WMT shift. The presence of brain edema was a marginally significant IOF. Craniotomy size, degree of head rotation, and ventricular penetration were not significant IOFs affecting WMT shift.CONCLUSIONSWMT shift occurs noticeably in tracts adjacent to the surgical lesions, and those motor tracts superficially placed in the operative hemisphere. Intraoperative probabilistic HARDI tractography following craniotomy, durotomy, and lesion resection may compensate for intraoperative WMT shift and improve neuronavigation accuracy.

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Pristo, Marcos Vinícius de Jesus, Claudine Pereira Dereczynski, Pedro Regoto de Souza, and Wallace Figueiredo Menezes. "Climatologia de Chuvas Intensas no Município do Rio de Janeiro." Revista Brasileira de Meteorologia 33, no. 4 (December 2018): 615–30. http://dx.doi.org/10.1590/0102-7786334005.

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Resumo Neste trabalho elabora-se uma climatologia de eventos de chuvas intensas (ECIs) no Município do Rio de Janeiro (MRJ) a partir dos dados observados pelo Sistema Alerta Rio no período 1997-2016. Um critério objetivo de identificação de ECIs é avaliado, confrontando-se dados de chuva com informações sobre os transtornos deflagrados por tais eventos sobre a cidade. O critério estabelece que um ECI se caracteriza por um total pluviométrico diário igual ou superior a seu percentil 95, com ocorrência no mesmo dia de pelo menos um registro de chuva em 15 minutos também igual ou superior a seu percentil 95. Ademais a climatologia da precipitação no MRJ é revisitada. Os resultados indicam que 33% do total pluviométrico anual médio no MRJ (1192 mm) ocorre durante 6,6 ECIs. Os máximos (mínimos) de ECIs são observados no Sumaré e Mendanha (na Saúde e Tijuca), numa média 30 dias por ano. Em média os ECIs ocorrem com maior frequência no verão (43,7%), seguido do outono (30,9%), na primavera (18,2%) e inverno (7,2%). Nota-se em geral uma tendência de aumento no número de ECIs durante o período analisado.

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Prado Junior, José Carlos, Thiago Costa Virgilio, and Roberto de Andrade Medronho. "Comparação da proporção de cura por tuberculose segundo cobertura e tempo de implantação de Saúde da Família e fatores socioeconômicos e demográficos no município do Rio de Janeiro, Brasil, em 2012." Ciência & Saúde Coletiva 21, no. 5 (May 2016): 1491–98. http://dx.doi.org/10.1590/1413-81232015215.03912016.

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Resumo A tuberculose (TB) consiste na maior causa de morte por doenças infecciosas em adultos. Está diretamente associada ao acesso aos serviços de saúde e a fatores socioeconômicos. A partir da reforma de atenção primária no Município do Rio de Janeiro (MRJ), a cobertura de saúde da família (SF) passou de 7% em 2010 para 48,2% em 2014. O objetivo deste artigo é comparar a proporção de cura por TB segundo a cobertura e tempo de implantação de SF e fatores socioeconômicos e demográficos no MRJ a partir dos casos novos em 2012. Foi encontrada associação entre cura por TB e a variável sexo OR 1,40 (IC95% 1,21-1,62) e entre pessoas residentes em favelas OR 0,86 (IC95% 0,73-1,02), porém não houve associação com a cobertura de SF e com o tempo de implantação das equipes. A cobertura de SF no MRJ se deu prioritariamente em áreas de maior vulnerabilidade. Aproximadamente 91% das equipes foram implantadas há menos de 05 anos da data do diagnóstico. Esses fatores provavelmente contribuíram para que não tenha sido possível detectar melhores resultados na cura de TB em áreas cobertas por SF no ano de 2012.

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Tao, Rongjia, Hong Tang, Kazi Tawhid-Al-Islam, Enpeng Du, and Jeongyoo Kim. "Electrorheology leads to healthier and tastier chocolate." Proceedings of the National Academy of Sciences 113, no. 27 (June 20, 2016): 7399–402. http://dx.doi.org/10.1073/pnas.1605416113.

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Chocolate is one of the most popular food types and flavors in the world. Unfortunately, at present, chocolate products contain too much fat, leading to obesity. Although this issue was called into attention decades ago, no actual solution was found. To bypass this critical outstanding problem, two manufacturers introduced some low-calorie fats to substitute for cocoa butter. Somehow, their products are not allowed in most countries. Here we show that this issue is deeply related to the basic science of soft matter, especially to the viscosity of liquid suspension and maximally random jammed (MRJ) density. When the concentration of cocoa solid is high, close to the MRJ density, removing a small amount of fat will jam the chocolate flow. Applying unconventional electrorheology to liquid chocolate with applied field in the flow direction, we aggregate the cocoa particles into prolate spheroids in micrometers. This microstructure change breaks the rotational symmetry, reduces liquid chocolate’s viscosity along the flow direction, and increases its MRJ density significantly. Hence the fat level in chocolate can be effectively reduced. We are expecting a new class of healthier and tastier chocolate soon.

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Bonnet, Suzanna Maria, Claudine Pereira Dereczynski, and Ana Nunes. "Caracterização Sinótica e Climatológica de Eventos de Chuva Pós-Frontal no Rio de Janeiro." Revista Brasileira de Meteorologia 33, no. 3 (September 2018): 547–57. http://dx.doi.org/10.1590/0102-7786333013.

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Resumo No Município do Rio de Janeiro (MRJ), verifica-se em certas situações de deslocamento de Sistemas Frontais (SFs), a ocorrência de chuvas fracas a moderadas, mesmo após a completa passagem do SF pelo Estado. Este fenômeno é conhecido na região como precipitação devido ao “efeito de circulação marítima”, mas não apresenta documentação, ficando restrito ao conhecimento dos previsores locais. O objetivo deste trabalho é elaborar uma climatologia da frequência de ocorrência desse fenômeno no MRJ para o período 2000-2013 e identificar as condições sinóticas associadas. A partir de imagens de satélite e dados de precipitação, as passagens de SFs pelo MRJ foram classificadas em três tipos: Pós-Frontais Sem Chuva (PFSC); Pós-Frontais Com Chuva (PFCC) e Pós-Frontais Excluídos (PFE). Os resultados indicam que mais da metade dos eventos são do tipo PFE (52%), 32% do tipo PFSC e 16% do tipo PFCC. Os casos PFE predominam no verão, os PFSC no inverno e primavera e os PFCC no outono. Os compostos dos casos PFSC e PFCC utilizando a Reanálise ERA-Interim indicam que a precipitação pós-frontal estaria associada à convergência de fortes ventos de sul junto à costa ao penetrar no continente, formando nuvens estratiformes, apesar do SF não estar mais atuando.

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FUJITA, Takeshi. "Aerodynamic Design Technology for MRJ." Proceedings of the Fluids engineering conference 2009 (2009): 3. http://dx.doi.org/10.1299/jsmefed.2009.3.

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Tian, Jianxiang, and Yang Jiao. "Predicting maximally random jammed packing density of non-spherical hard particles via analytical continuation of fluid equation of state." Physical Chemistry Chemical Physics 22, no. 39 (2020): 22635–44. http://dx.doi.org/10.1039/d0cp03799k.

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Domingues, Rosa Maria Soares Madeira, Lilian de Mello Lauria, Valeria Saraceni, and Maria do Carmo Leal. "Manejo da sífilis na gestação: conhecimentos, práticas e atitudes dos profissionais pré-natalistas da rede SUS do município do Rio de Janeiro." Ciência & Saúde Coletiva 18, no. 5 (May 2013): 1341–51. http://dx.doi.org/10.1590/s1413-81232013000500019.

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Este artigo objetiva avaliar os conhecimentos, as práticas e as atitudes dos profissionais pré-natalistas da rede de serviços públicos de saúde (SUS) do município do Rio de Janeiro (MRJ) e identificar as principais barreiras para a implantação dos protocolos assistenciais de manejo da sífilis na gestação. Estudo transversal com 102 profissionais pré-natalistas da rede SUS do MRJ, correspondendo a uma taxa de resposta de 70% dentre os elegíveis. Foi realizada análise uni e bivariada com utilização do software SPSS 16.0. Foram verificadas diversas barreiras relacionadas ao conhecimento e à familiaridade com os protocolos assistenciais, dificuldades na abordagem das DST, questões dos usuários e contexto organizacional, que apresentaram distribuição distinta segundo tipo de serviço de saúde. Profissionais com mais acesso a treinamentos e manuais técnicos apresentaram melhor desempenho, sendo esses efeitos discretos. A identificação de barreiras para a adoção de protocolos assistenciais é fundamental para a formulação de estratégias de intervenção. O acesso ao conteúdo dos protocolos por treinamentos e manuais técnicos mostraram efeito discreto na melhoria das condutas assistenciais, sendo necessárias outras abordagens de educação continuada dos profissionais.

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Głodek, Aleksandra Monika. "Znaczenie tomografii komputerowej w diagnostyce nowotworów wątroby." Letters in Oncology Science 14, no. 3 (September 11, 2017): 75–79. http://dx.doi.org/10.21641/los.2017.14.3.38.

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Badania obrazowe są integralną częścią diagnostyki chorób nowotworowych. Do badań tych zalicza się między innymi: ultrasonografię (USG), tomografię komputerową (TK) oraz rezonans magnetyczny (MRJ). Wykonanie ultrasonografii jest stosunkowo proste i tanie. W oparciu o przeprowadzone badanie USG, radiolog zazwyczaj jest w stanie ocenić wielkość wątroby, echogeniczność, czy obecność struktur patologicznych w jej obrębie. W celu uzyskania bardziej szczegółowej wiedzy na temat zmiany, pacjentom zaleca się badanie tomograficzne lub badanie rezonansem magnetycznym z użyciem środka kontrastowego. TK wykorzystuje promieniowanie jonizujące, dzięki czemu powinna być zlecana według ściśle określonych wskazań. W trakcie jednego badania wykonuje się wiele zdjęć rentgenowskich, co istotnie wpływa na dawkę zaabsorbowaną w ciągu roku przez pacjenta. Nowotwory wątroby stanowią 7% wszystkich nowotworów. Do czynników zwiększających ryzyko zachorowania na nowotwór wątroby zalicza się między innymi marskość wątroby, zakażenie wirusem B lub C, a także nadużywanie alkoholu. Badanie TK pozwala na zdefiniowanie charakteru zmiany, a także jest pomocne w określeniu jej zasięgu. Procedura ta umożliwia opisanie stosunku guza do struktur położonych w pobliżu. MRJ może być alternatywą w przypadku braku uzyskania satysfakcjonującej wiedzy na temat nowotworu w badaniach poprzednich.

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ANDO, Yasushi. "Human and Environment-Friendlier Airplane : MRJ Case." Journal of the Society of Mechanical Engineers 111, no. 1075 (2008): 512–13. http://dx.doi.org/10.1299/jsmemag.111.1075_512.

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Sgherza, Nicola, Vito Garrisi, Giacoma De Tullio, Simona Serratì, Angela Iacobazzi, Antonello Rana, Angela La Pietra, et al. "Impact of Proteomic Profile of Peripheral Blood and Bone Marrow Sera on Molecular Response in Patients with Chronic Myeloid Leukemia: Preliminary Data." Blood 124, no. 21 (December 6, 2014): 5515. http://dx.doi.org/10.1182/blood.v124.21.5515.5515.

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Abstract BACKGROUND. Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by an aberrant protein (BCR–ABL) which is a constitutively active tyrosine kinase. According to the latest ELN recommendations for the management of CML, molecular response (MR) is best assessed according to the International Scale (IS) as the ratio of BCR-ABL1 transcripts to ABL1 transcripts, or other internationally recognized control transcripts. It is expressed and reported as BCR-ABL1% on a log scale where 10%, 1%, 0.1%, 0.01%, 0.0032%, and 0.001% correspond to a decrease of respectively 1 (MR1), 2 (MR2), 3 (MR3), 4 (MR4), 4.5 (MR4.5) logs below the standard baseline that was used in the IRIS study. Recent advances in the proteomic field have allowed us to better understand the biology of several cancer types and/or discover new candidate biomarkers, but very few data are available in CML. AIMS. The purpose of this study was to evaluate a possible correlation between depth of MR and proteomic profile in sera samples obtained from the peripheral blood and bone marrow of CML patients. PATIENTS AND METHODS Samples were consecutively and prospectively obtained from 20 CML patients observed between January and June 2014 at the Hematology Unit of the National Cancer Research Centre “Istituto Tumori Giovanni Paolo II” in Bari, Italy. Each individual involved in the study signed an informed consent form authorizing the Institute to utilize their biological tissues for research purposes. All patients at diagnosis displayed the classic t(9;22) Ph chromosome according to standard cytogenetics. The BCR/ABL transcript at RT-PCR was b3a2 in 13 patients and b2a2 in 7 patients. Peripheral blood and bone marrow samples were centrifuged within 30 minutes of sample taking. Serum specimens were immediately collected and frozen at −80°C. Twenty sera from peripheral blood were sampled from 5 patients in MR1 response, four in MR2, eight in MR3, two in MR4 and 1 patient at diagnosis; for eleven patients serum from bone marrow was also available; in particular 2 were sampled from patients in MR1, 3 in MR2, 4 in MR3, 1 in MR4 and 1 at diagnosis. Patients were grouped in two cohorts: the first comprised those with lower molecular response to MR3 (group A: 10 patients) and the second greater than or equal to MR3 (group B: 10 patients). The association of proteomic profile with molecular response was performed using the SELDI ToF Mass Spectrometry platform. Each specimen was spotted on an IMAC30 metal affinity protein-chip, prepared according to the manufacturer's instructions, and analyzed in duplicate. RESULTS Fourteen differentially expressed peaks were highlighted when comparing peripheral sera from group A and group B, but none was statistically significant. When comparing 11 available serum samples from the bone marrow of groups A (6) and B (5), four peaks (m/z 10629, m/z 3889, m/z 7772, m/z 7987) were reported as differentially expressed in a statistically significant way (p<0.05). Focusing the differential expression analysis in peripheral sera only on MR1 patients (including one patient at diagnosis) versus MR4 patients, one peak at m/z 11092 was identified as significantly and differentially expressed (p < 0.05) (Figure 1). Similarly, comparing bone marrow sera only from MR1 and MR4 patients respectively, 32 peaks were differentially expressed. Once again the peak at m/z 11092 resulted under expressed in MR1 patients, and interestingly the single patient at diagnosis had the lowest value. No statistical differences were evidenced when comparing peripheral blood and bone marrow sera obtained from b3a2 and b2a2 patients. CONCLUSIONS These preliminary data suggest that an over-expression of m/z 11092 in serum obtained from peripheral blood and bone marrow could be associated with a deeper molecular response; further investigations are needed on a larger number of patients in order to confirm or refute our results and, to definitively characterize the peak at m/z 11092. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

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Ramos, Maurício, Ana Laura Brandão, Leonardo Graever, and Carlos Eduardo Aguilera Campos. "Melhoria contínua da qualidade." Revista Brasileira de Medicina de Família e Comunidade 16, no. 43 (September 26, 2021): 2736. http://dx.doi.org/10.5712/rbmfc16(43)2736.

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Introdução: A melhoria contínua da qualidade (MCQ) em saúde pode ser conceituada como um compromisso de melhorar continuamente a qualidade do cuidado, centrando-se nas preferências e necessidades das pessoas que usam os serviços. No Brasil, entre os anos de 2009 e 2016, houve grande incentivo à avaliação do desempenho e melhoria da qualidade das equipes de saúde da família (eSF), através do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica (PMAQ). No município do Rio de Janeiro (MRJ), ocorreram os seminários de accountability, um processo organizado pela gestão municipal para apresentação e avaliação de resultados por avaliadores externos a partir de uma matriz de indicadores previamente definidos, e os seminários de avaliação e melhoria da qualidade, organizados em 2018, com a prerrogativa do uso de ferramentas de MCQ pelas eSF e gestão local. Objetivos: Analisar a experiência das equipes de APS do MRJ em utilizar ferramentas de MCQ no seu processo de trabalho. Métodos: Foram realizadas entrevistas semiestruturadas aos profissionais que compõe a coordenação técnica das unidades básicas de saúde, avaliando-se a percepção geral sobre o trabalho e a rede, a presença de planejamento estratégico e a compreensão sobre os seminários de avaliação e melhoria da qualidade, por meio de da análise do conteúdo das entrevistas. Resultados: Dos entrevistados, 54% avaliam seu trabalho como “regular” e 36 % como “ruim” e todos entrevistados levaram em consideração o atual cenário da APS do MRJ para autoavaliação. Dos participantes, 86% relataram que as reuniões de equipe não acontecem na periodicidade prevista, contudo apontam para a ênfase no planejamento dos processos de trabalho nas reuniões. Somente 10% informaram que utilizam indicadores em saúde para nortear as ações a serem discutidas em reunião. Apenas 14% conseguiram realizar o itinerário completo dos seminários de MCQ com apoio de toda a equipe. Conclusão: Evidenciou-se a importância da institucionalização da MCQ e da avaliação em saúde, a influência negativa de um cenário político adverso e seu impacto nos processos de MCQ.

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Ostrowska, Małgorzata, Jerzy Bellwon, Marek Koziński, Adam Ostrowski, Piotr Adamski, Piotr Niezgoda, Krzysztof Strojek, and Marcin Gruchała. "Prevalence of electrocardiographic left ventricular hypertrophy among patients with coronary artery disease and diabetes mellitus." Medical Research Journal 1, no. 1 (August 16, 2016): 1–9. http://dx.doi.org/10.5603/mrj.2016.0001.

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Niezgoda, Piotr, Joanna Sikora, Malwina Barańska, Karolina Obońska, Piotr Adamski, Marek Koziński, Michał Marszałł, and Jacek Kubica. "Impact of ticagrelor administration strategy on its pharmacokinetics and pharmacodynamics in patients with unstable angina pectoris: a protocol of a randomized study." Medical Research Journal 1, no. 1 (August 16, 2016): 10–14. http://dx.doi.org/10.5603/mrj.2016.0002.

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Skowron, Krzysztof, Justyna Bauza-Kaszewska, Agnieszka Kaczmarek, Anna Budzyńska, Joanna Kwiecińska-Piróg, Adrian Reśliński, and Eugenia Gospodarek-Komkowska. "Inactivation of Clostridium sporogenes and Geobacillus stearothermophilus spores with the use of microwave and steam sterilizers and microwave oven." Medical Research Journal 1, no. 1 (August 16, 2016): 15–22. http://dx.doi.org/10.5603/mrj.2016.0003.

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Kubica, Julia Maria, Krzysztof Pstrągowski, Piotr Adamski, Michał Kasprzak, Ewa Obońska, Karolina Obońska, Anita Dąbrowska, et al. "Mild therapeutic hypothermia for patients with acute coronary syndrome and cardiac arrest treated with percutaneous coronary intervention (UNICORN). The design and rationale for the prospective, observational, multicenter study." Medical Research Journal 1, no. 1 (August 16, 2016): 23–27. http://dx.doi.org/10.5603/mrj.2016.0004.

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Magielski, Przemysław, Anna Szcześniak, Karolina Obońska, Wioleta Stolarek, Iwona Świątkiewicz, Adam Sukiennik, Zofia Grąbczewska, Grzegorz Grześk, Marek Koziński, and Jacek Kubica. "Impact of prior statin therapy on evaluation of the inflammatory process and cortisol concentration in patients with the first ST-segment elevation myocardial infarction undergoing coronary angioplasty with bare metal stent implantation." Medical Research Journal 1, no. 1 (August 16, 2016): 28–36. http://dx.doi.org/10.5603/mrj.2016.0005.

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Buszko, Katarzyna, Karolina Obońska, Piotr Michalski, Agata Kosobucka, Aleksandra Jurek, Marzena Wawrzyniak, Wioleta Stolarek, Łukasz Pietrzykowski, Anna Andruszkiewicz, and Aldona Kubica. "The Adherence Scale in Chronic Diseases (ASCD). The power of knowledge: the key to successful patient — health care provider cooperation." Medical Research Journal 1, no. 1 (August 16, 2016): 37–42. http://dx.doi.org/10.5603/mrj.2016.0006.

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Pater, Agnieszka, Aneta Mańkowska-Cyl, Joanna Siódmiak, Agnieszka Jatczak-Gaca, Andrzej Kurylak, and Grażyna Sypniewska. "Biomarkers of bone cell activity in children and adolescents with newly diagnosed, untreated acute lymphoblastic leukemia." Medical Research Journal 1, no. 1 (August 16, 2016): 43–47. http://dx.doi.org/10.5603/mrj.2016.0007.

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Świątkiewicz, Iwona, Marek Woźnicki, Adam Sukiennik, and Jacek Kubica. "Device-associated thrombus after percutaneous left atrial appendage closure: a case report and literature review." Medical Research Journal 1, no. 1 (August 16, 2016): 48–52. http://dx.doi.org/10.5603/mrj.2016.0008.

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Sysakiewicz, Martyna, Adriana Czyż, Marcin Ksieniewicz, Beata Sulikowska, and Jarosław Czyż. "Monoclonal gammopathy with renal significance." Medical Research Journal 1, no. 2 (December 2, 2016): 53–57. http://dx.doi.org/10.5603/mrj.2016.0009.

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Obońska, Ewa, and Iwona Świątkiewicz. "Left atrial appendage closure: therapeutic option or solution?" Medical Research Journal 1, no. 2 (December 2, 2016): 58–67. http://dx.doi.org/10.5603/mrj.2016.0010.

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Sikora, Joanna, Piotr Niezgoda, Malwina Barańska, Krzysztof Pstrągowski, Aleksandra Karczmarska-Wódzka, Emilia Siemińska, Michał Piotr Marszałł, Grzegorz Grześk, and Jacek Kubica. "The influence of metoclopramide on pharmacokinetics and pharmacodynamics of ticagrelor in patients with unstable angina pectoris receiving concomitant treatment with morphine — a protocol of a randomized trial." Medical Research Journal 1, no. 2 (December 2, 2016): 68–71. http://dx.doi.org/10.5603/mrj.2016.0011.

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Ostrowska, Małgorzata, Jerzy Bellwon, Piotr Adamski, Marek Koziński, Piotr Niezgoda, Adam Ostrowski, Łukasz Fidor, Krzysztof Strojek, and Marcin Gruchała. "Pathological Q waves as an indicator of prior myocardial infarction in patients with coronary artery disease and diabetes mellitus: a comparison of the prevalence and diagnostic accuracy according to present and former criteria." Medical Research Journal 1, no. 2 (December 2, 2016): 72–80. http://dx.doi.org/10.5603/mrj.2016.0012.

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Ratajczak, Jakub, Ewa Jaworska, Maria Tomczak, Emilia Kolasińska, Paulina Badziągowska, Jan Kłopocki, Iwona Świątkiewicz, and Adam Sukiennik. "Treatment of severe mitral regurgitation with MitraClip system — a single-centre study." Medical Research Journal 1, no. 2 (December 2, 2016): 81–87. http://dx.doi.org/10.5603/mrj.2016.0013.

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Holec, Elżbieta, Damian Czarnecki, Krzysztof Opozda, Malwina Tudorowska, and Marcin Ziółkowski. "The life satisfaction level of obese people with depressive disorders compared to healthy individuals." Medical Research Journal 1, no. 2 (December 2, 2016): 88–91. http://dx.doi.org/10.5603/mrj.2016.0014.

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Pranevičius, Robertas, Justas Keršulis, Kasparas Briedis, Ąžuolas Sirtautas, Norvydas Zapustas, and Ramūnas Unikas. "Evaluation of two years’ treatment results after implantation of Biolimus A9 stents in coronary arteries." Medical Research Journal 1, no. 2 (December 2, 2016): 92–94. http://dx.doi.org/10.5603/mrj.2016.0015.

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Cembrowska, Paulina, Anna Stefańska, and Grażyna Odrowąż-Sypniewska. "Obesity phenotypes: normal-weight individuals with metabolic disorders versus metabolically healthy obese." Medical Research Journal 1, no. 3 (March 28, 2017): 95–99. http://dx.doi.org/10.5603/mrj.2016.0016.

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Wróblewska, Joanna, Agata Białucha, Emilia Adrianna Kubik, and Eugenia Gospodarek-Komkowska. "Biofilm formation of Streptococcus pneumoniae from bronchial alveolar lavage and from nasal swab." Medical Research Journal 1, no. 3 (March 28, 2017): 100–104. http://dx.doi.org/10.5603/mrj.2016.0017.

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Stasienko, Elzbieta, and Lukasz Wicherek. "Therapeutic results of patients with endometriosis and ovarian cancer." Medical Research Journal 1, no. 3 (March 28, 2017): 105–7. http://dx.doi.org/10.5603/mrj.2016.0018.

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Zapustas, Norvydas, Robertas Pranevičius, Kasparas Briedis, Ąžuolas Sirtautas, and Ramūnas Unikas. "Twelve-month clinical outcomes of transradial coronary artery intervention: comparison of the right and left radial artery approach." Medical Research Journal 1, no. 3 (March 28, 2017): 108–10. http://dx.doi.org/10.5603/mrj.2016.0019.

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Sirtautas, Ąžuolas, Kasparas Briedis, Robertas Pranevičius, Norvydas Zapustas, and Živilė Valuckienė. "Differences in mitral annulus remodelling in acute anterior ST elevation and acute inferior ST elevation myocardial infarction." Medical Research Journal 1, no. 3 (March 28, 2017): 111–13. http://dx.doi.org/10.5603/mrj.2016.0020.

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Umińska, Julia Maria, Marek Koziński, Krzysztof Pstrągowski, Przemysław Paciorek, Tomasz Fabiszak, Joanna Sikora, Michał Marszałł, Grzegorz Grześk, and Jacek Kubica. "Platelet reactivity during mild therapeutic hypothermia in patients with acute myocardial infarction treated with ticagrelor: study protocol of a single-centre study." Medical Research Journal 1, no. 4 (May 19, 2017): 115–19. http://dx.doi.org/10.5603/mrj.2016.0021.

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Michalski, Piotr, Agata Kosobucka, Łukasz Pietrzykowski, Marzena Wawrzyniak, Aleksandra Jurek, Michał Kasprzak, Mirosława Felsmann, and Aldona Kubica. "Knowledge and learning preferences of patients with myocardial infarction." Medical Research Journal 1, no. 4 (May 19, 2017): 120–24. http://dx.doi.org/10.5603/mrj.2016.0022.

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Nowacki, Wieslaw, Agnieszka Pater, Joanna Siodmiak, and Grazyna Sypniewska. "Thyroid-stimulating hormone within low-normal range is related to imbalance of bone remodeling in euthyroid postmenopausal women with osteoporotic fractures." Medical Research Journal 1, no. 4 (May 19, 2017): 125–29. http://dx.doi.org/10.5603/mrj.2016.0023.

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Kasprzak, Piotr, Walenty M. Nyka, Kamil Chwojnicki, Katarzyna Ziejka, and Piotr Lutowski. "The predictive value of selected functional and clinical parameters in stroke rehabilitation." Medical Research Journal 1, no. 4 (May 19, 2017): 130–34. http://dx.doi.org/10.5603/mrj.2016.0024.

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Siódmiak, Joanna, Tomasz Siódmiak, Agata Tarczykowska, Katarzyna Czirson, Jacek Dulęba, and Michał Piotr Marszałł. "Metabolic chiral inversion of 2-arylpropionic acid derivatives (profens)." Medical Research Journal 2, no. 1 (September 21, 2017): 1–5. http://dx.doi.org/10.5603/mrj.2017.0001.

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Bielińska, Joanna, Ariel Liebert, Natalia Lesiewska, Maciej Bieliński, Artur Mieczkowski, Paulina Sopońska-Brzoszczyk, Bartosz Brzoszczyk, et al. "Depressive and anxiety symptoms among patients with inflammatory bowel diseases." Medical Research Journal 2, no. 1 (September 21, 2017): 6–12. http://dx.doi.org/10.5603/mrj.2017.0002.

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Dutsch-Wicherek, Magdalena, Magdalena Bańkowska-Woźniak, Wojciech Kazmierczak, Klaudia Cierniak-Kożuch, Konrad Dziobek, and Łukasz Wicherek. "The quality of life and the occurrence of dysphagia in patients with head and neck cancer following combined oncological treatment." Medical Research Journal 2, no. 1 (September 21, 2017): 13–19. http://dx.doi.org/10.5603/mrj.2017.0003.

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