Academic literature on the topic 'MPSI'
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Journal articles on the topic "MPSI"
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Sornalingam, Krishanthy, Ahmed Javed, Tariq Aslam, Panagiotis Sergouniotis, Simon Jones, Arunabha Ghosh, and Jane Ashworth. "Variability in the ocular phenotype in mucopolysaccharidosis." British Journal of Ophthalmology 103, no. 4 (August 17, 2018): 504–10. http://dx.doi.org/10.1136/bjophthalmol-2017-311749.
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PurposeMucopolysaccharidoses (MPSs) are a heterogeneous group of lysosomal storage disorders. Ocular complications (such as corneal clouding, retinopathy and optic neuropathy) are common. Notably, there is a paucity of data on the effect of genotype and systemic treatments (enzyme replacement therapy or haematopoietic stem cell transplantation) on the ocular phenotype in MPS. We prospectively studied the ocular features of patients with MPSI (Hurler/Hurler-Scheie/Scheie), MPSIV (Morquio) and MPSVI (Maroteaux-Lamy), to evaluate the effect of different therapeutic interventions and to correlate the findings with genetic and biomarker data.MethodsProspective observational cohort study. Study participants underwent detailed ocular examination including visual acuity; assessment of corneal clouding (Iris camera Corneal Opacification Measure score and Pentacam densitometry) and retinal and optic nerve imaging (optical coherence tomography and wide-field fundus imaging). Data on genotype, biomarkers and delivered therapies (type and length of treatment) were also collected for each patient where available.ResultsOverall, 21 patients with MPSI, 4 patients with MPSIV and 3 patients with MPSVI were recruited. Corneal clouding scores were higher in MPSI compared with MPSIV and MPSVI. Retinopathy was evident in patients with MPSI only. Association was observed between corneal clouding and biomarkers in MPSI, MPSIV and MPSVI. However, no clear association was seen between genotype or treatment type and ocular phenotype.ConclusionsThe ocular phenotype in MPS is variable, with corneal clouding occurring in MPSI, MPSIV and MPSVI, and retinopathy in MPSI only. There was an association between corneal clouding and efficacy of systemic treatment as measured by biomarkers.
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Eremina, A. S., A. Yu Kharin, Yu V. Kargina, and V. Yu Timoshenko. "Stabilization of porous silicon nanoparticles by PEGalization in water." Journal of Physics: Conference Series 2058, no. 1 (October 1, 2021): 012013. http://dx.doi.org/10.1088/1742-6596/2058/1/012013.
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Abstract Mesoporous silicon (mPSi) nanoparticles (NPs) are stabilized by polyethylene glycol (PEG) chains during mechanical grinding in a ball mill that is used to form mPSi-PEG-NPs. The structure, composition, and properties of the obtained samples are studied by means of the dynamic light scattering, scanning electron microscopy and Fourier-transform infrared spectroscopy. The proposed PEGalization procedure is an effective way of regulating the dissolution of mPSi-NPs in water and it is promising for potential application of mPSi-NPs in drug delivery.
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De Ponti, Giada, Samantha Donsante, Marta Frigeni, Alice Pievani, Alessandro Corsi, Maria Ester Bernardo, Mara Riminucci, and Marta Serafini. "MPSI Manifestations and Treatment Outcome: Skeletal Focus." International Journal of Molecular Sciences 23, no. 19 (September 22, 2022): 11168. http://dx.doi.org/10.3390/ijms231911168.
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Mucopolysaccharidosis type I (MPSI) (OMIM #252800) is an autosomal recessive disorder caused by pathogenic variants in the IDUA gene encoding for the lysosomal alpha-L-iduronidase enzyme. The deficiency of this enzyme causes systemic accumulation of glycosaminoglycans (GAGs). Although disease manifestations are typically not apparent at birth, they can present early in life, are progressive, and include a wide spectrum of phenotypic findings. Among these, the storage of GAGs within the lysosomes disrupts cell function and metabolism in the cartilage, thus impairing normal bone development and ossification. Skeletal manifestations of MPSI are often refractory to treatment and severely affect patients’ quality of life. This review discusses the pathological and molecular processes leading to impaired endochondral ossification in MPSI patients and the limitations of current therapeutic approaches. Understanding the underlying mechanisms responsible for the skeletal phenotype in MPSI patients is crucial, as it could lead to the development of new therapeutic strategies targeting the skeletal abnormalities of MPSI in the early stages of the disease.
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Woloszynek, Josh C., Trey Coleman, Clay F. Semenkovich, and Mark S. Sands. "Lysosomal Dysfunction Results in Altered Energy Balance." Journal of Biological Chemistry 282, no. 49 (October 2, 2007): 35765–71. http://dx.doi.org/10.1074/jbc.m705124200.
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The mucopolysaccharidosis (MPS) type VII mouse was originally described as the adipose storage deficiency mouse because of its extreme lean phenotype of unknown etiology. Here, we show that adipose storage deficiency and lower leptin levels are common to five different lysosomal storage diseases (LSDs): MPSI, MPSIIIB, MPSVII, Niemann-Pick type A/B, and infantile neuronal ceroid lipofuscinosis. Elevated circulating pro-inflammatory proteins (VCAM1 and MCP1) were found in multiple LSDs. Multiple anti-inflammatory strategies (dexamethasone, MCP1 deficiency, M3 expression) failed to alter adiposity in LSD animals. All of the models had normal or greater caloric intake and lower to normal metabolic rate, fasting plasma glucose, non-esterified fatty acids, cholesterol, and triglycerides. Triglycerides were lower in the livers of MPSI mice, and the trend was lower in the muscle. Lipid absorption and processing in MPSI mice were indistinguishable from those in normal mice following oral gavage of olive oil. The increased lean mass of MPSI and MPSIIIB mice suggests a shift in adipose triglycerides to lysosomal storage. In agreement, MPSI livers had a similar total caloric content but reduced caloric density, indicating a shift in energy from lipids to proteins/carbohydrates (lysosomal storage). Enzyme replacement therapy normalized the caloric density within 48 h without reducing total caloric content. This was due to an increase in lipids. Recycling of stored material is likely reduced or nonexistent. Therefore, to maintain homeostasis, energy is likely diverted to synthesis at the expense of typical energy storage depots. Thus, these diseases will serve as important tools in studying the role of lysosome function in metabolism and obesity.
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Sunardi, Bambang, Sulastri, Dwikorita Karnawati, Urip Haryoko, Supriyanto Rohadi, Sigit Pramono, and Ari Sungkowo. "Acceleration Response Spectra for M 7.4 Donggala Earthquake and Comparison with Design Spectra." Journal of Sustainable Engineering: Proceedings Series 1, no. 1 (June 30, 2019): 20–26. http://dx.doi.org/10.35793/joseps.v1i1.3.
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A 7.4 magnitude earthquake have strucked Donggala on September 28th 2018, followed by tsunami and liquefaction which hit Palu, Central Sulawesi, a few minutes later. This event had resulted in damage to buildings, and caused more than 2,000 people were killed and injured. Indonesia already have a building code in form of SNI 1726:2002 which had been updated to SNI 1726:2012. This paper analyses the hazard level caused by the 2018 Donggala earthquake compared to the existing design spectra, as mentioned in SNI 1726:2002 and SNI 1726:2012. A simple analysis was carried out by comparing Donggala earthquake’s acceleration response spectra with the existing design spectra, at the MPSI accelerograph station. The site class at MPSI station is hard soil (SC). The seismic hazard in Palu and Donggala refers to SNI 1726:2002 is included in the earthquake area 4. The maximum earthquake response factor for earthquake area 4 is about 0.6 for hard soil type (SC). The MPSI station recorded peak ground acceleration of Donggala earthquake around 0.14 g. The acceleration response spectra recorded at the MPSI station showed a peak value of around 0.71 g for the N component. This value is actually still below the design spectra referring to SNI 1726:2012, which the peak value is 0.88 g for SC, but, it exceeded the design spectra of SNI 1726:2002.
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Pei, Song, Xingyao Yin, and Kun Li. "Full-time domain matching pursuit and empirical mode decomposition based sparse fixed-point seismic inversion." Journal of Geophysics and Engineering 19, no. 2 (April 2022): 255–68. http://dx.doi.org/10.1093/jge/gxac014.
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Abstract Sparse seismic inversion is wildly utilized for reservoir prediction and resolution improvement. Matching pursuit (MP) is an effective algorithm for solving L0-norm and obtaining sparse inversion results. Sparse seismic inversion based on MP (MPSI) can estimate the sparse parameters of subsurface from observations by controlling the iterations and threshold. However, the low convergence and stability limit the application of MPSI. To accelerate the convergence of MP, the full-time domain matching pursuit (FTMP) algorithm is first proposed. The seismic inversion based on FTMP can realize the multi-point inversion simultaneously instead of searching the inversion results one by one, which is the process of MPSI. Also, the prior model constraint is then involved in the objective function to improve the stability and the layer-boundary fidelity of the inversion results. Furthermore, the empirical mode decomposition (EMD) algorithm is introduced into inversion framework to recover the features of the seismic signal from the noisy seismic signal. The fixed-point (FP) algorithm is adopted to solve the objective function in this study. The optimal inversion results can be estimated after finite iterations by the FP algorithm. Combining the FTMP sparse seismic inversion framework, prior model constraint, EMD and FP algorithms, a complete sparse seismic inversion method named the full-time domain matching pursuit-based sparse fixed-point seismic inversion is ultimately proposed. The synthetic and field examples are utilized to demonstrate the stability and practicality of this approach. Compared with MPSI, the inversion results of the proposed method have higher resolution and fidelity of the layer-boundary.
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Hudson, Walter W., and Steven L. McMurtry. "Comprehensive Assessment in Social Work Practice: The Multi-Problem Screening Inventory." Research on Social Work Practice 7, no. 1 (January 1997): 79–98. http://dx.doi.org/10.1177/104973159700700105.
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Findings are reported from an initial evaluation of a new multidimensional assessment tool, the Multi-Problem Screening Inventory (MPSI). The inventory gathers information on 27 different areas of personal and social functioning and is designed for use by human service practitioners in a variety of settings. Basic guidelines for using the instrument are detailed, with emphasis given to the preparation and interpretation of graphic profiles for rapid but comprehensive client assessments. Reliabilities and validities obtained for each of the subscales are then reviewed, along with suggestions for further development and use of the MPSI in clinical trials and research applications.
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Ames, Elizabeth G., Rachel Fisher, Mary Kleyn, and Ayesha Ahmad. "Current Practices for U.S. Newborn Screening of Pompe Disease and MPSI." International Journal of Neonatal Screening 6, no. 3 (September 2, 2020): 72. http://dx.doi.org/10.3390/ijns6030072.
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Two lysosomal storage disorders (LSDs), Pompe disease and Mucopolysaccharidosis type I (MPSI) were added to the Recommended Uniform Screening Panel (RUSP) for newborn screening (NBS) in 2015 and 2016, respectively. These conditions are being screened with variable practice in terms of primary and reflex analytes (either biochemical or molecular testing) as well as collection of short- and long-term follow-up elements. The goal of this study is to evaluate practices of state health departments in regards to screening methods and follow-up data collected. We conducted online surveys and phone questionnaires to determine each U.S. state’s practices for screening and follow-up of positive newborn screens. We report the first snapshot of practices for NBS for the LSDs included on the RUSP. All 50 U.S. states responded to our survey. The majority of U.S. states are not currently screening for Pompe disease and MPSI as of March 2020, but this number will increase to 38 states in the coming 1–3 years based on survey results. Our survey identifies data elements used by state health departments for short-and long-term follow-up that could serve as the basis of common elements for larger, public health-based analyses of the benefits and efficacy of screening for Pompe disease and MPSI.
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Vashakmadze, Nato, Natalya Zhurkova, Ekaterina Zakharova, Marina Babaikina, Anastasia Rykunova, and Leyla Namazova-Baranova. "Mild forms of mucopolysaccharidosis type I (MPSI)." Molecular Genetics and Metabolism 132, no. 2 (February 2021): S108. http://dx.doi.org/10.1016/j.ymgme.2020.12.265.
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Kassisse, Elias, Joanna Jimenez, Nelly Mayo, and Jorge Kassisse Limongi. "Sulfato de magnesio vs aminofilina como segunda línea de manejo en niños con asma aguda severa. Ensayo clínico aleatorizado." Andes Pediatrica 92, no. 3 (June 22, 2021): 367. http://dx.doi.org/10.32641/andespediatr.v92i3.2969.
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Los medicamentos de segunda línea en el asma aguda generalmente son de administración endovenosa: salbutamol, sulfato de magnesio y aminofilina.Objetivo: comparar la eficacia y seguridad del uso de sulfato de magnesio vs aminofilina en niños que no respondieron al tratamiento inicial.Pacientes y Método: Ensayo clínico aleatorizado. Los niños que no mejoraron el Score de Índice Pulmonar Modificado (mPSI) fueron aleatorizados a recibir sulfato de magnesio (50 mg/Kg/dosis única) o aminofilina (5 mg/Kg/dosis seguida de infusión continua a 1 mg/kg/hora por 3 h). Resultados primarios: cambios en el mPSI y la saturación de oxígeno; resultados secundarios: tasa de hospitalización, necesidad de traslado a unidad de cuidados intensivos, uso de una tercera intervención y efectos adversos.Resultados: Se estudiaron 131 pacientes (66 pacientes en el grupo de la aminofilina y 65 MgSO4). La edad promedio fue de 5 ± 2,3 años, los parámetros demográficos y clínicos no difirieron entre los grupos. En el grupo que recibió sulfato el mPSI y la saturación de oxigeno se modificaron favorablemente de forma significativa desde 13,1 ± 1,3 hasta 4,9 ± 2,5 (p < 0,001) y de 3,3 ± 2,5; (p 0,021), respectivamente. De igual forma en el grupo que recibió el sulfato se redujo el riesgo de admisión (RR 0,68 95% IC [0,56; 0,82]) y el de fallas secundaria (0,16 95% IC 95% [0,07; 0,38]). Solo se registró un evento adverso (taquicardia).Conclusión: La administración de una dosis única de sulfato de magnesio demostró ser más eficaz y segura que el uso de la aminofilina como agente de segunda línea.
Dissertations / Theses on the topic "MPSI"
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Camassola, Melissa. "Modelo murino de mucopolissacaridose tipo I (MPSI) : desenvolvimento de vetores virais e estudo de parâmetros fisiopatológicos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/13641.
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A mucopolissacaridose tipo I (MPS I) é uma doença lisossomal. A enzima envolvida com essa doença é a a-L-iduronidase (IDUA), e suas alterações levam a depósitos dos glicosaminoglicanos heparan e dermatan sulfato. As características fenotípicas da doença compreendem entre outras características malformações ósseas, hepatoesplenomegalia, problemas cardíacos, opacidade da córnea e retardo mental. O tratamento de MPS I atualmente se baseia em reposição enzimática e transplante de medula óssea. Levando em conta que esses tratamentos ainda não levam a uma correção dos danos ao sistema nervoso central (SNC), há necessidade do desenvolvimento de novos tratamentos para MPS I. Ainda outro problema da MPS I é a falta de estudos sobre os danos fisiológicos resultantes, principalmente no SNC. Visando contribuir com estes pontos, nosso trabalho teve como objetivo (a) o desenvolvimento de três vetores virais para posteriores ensaios pré-clínicos de terapia gênica e (b) o detalhamento da caracterização fisiopatológica de camundongos representando um modelo para MPS I, enfocando alguns aspectos do SNC. Foram produzidos três vetores virais com o cDNA da IDUA humana. O vetor baseado no vírus da imunodeficiência humana (HIV), apesar de baixos títulos virais, foi capaz de aumentar em até 60 vezes a atividade da IDUA nas células transduzidas. Um segundo vetor, baseado no vírus da leucemia murina de Moloney (MoMLV) foi capaz de transduzir células-tronco mesenquimais derivadas de medula óssea do modelo murino de MPS I, sendo assim ótima ferramenta para terapia gênica ex vivo. O terceiro vetor, baseado no vírus da imunodeficiência felina (FIV) mostrou funcionalidade inferior quando comparado aos outros sistemas virais, e deve ser aperfeiçoado para utilização terapêutica. A caracterização do modelo foi feita através do estudo da fosforilação de proteínas de neurofilamentos em diferentes estruturas do cérebro de camundongos MPS I. Os resultados mostraram, além de alterações na fosforilação direta das proteínas analisadas, uma hiperfosforilação na ERK1/2 de córtex e hipocampo. Depósitos de gangliosídeos foram investigados de forma individual no cerebelo, córtex, hipocampo e hipotálamo, sendo detectadas diferenças específicas para cada estrutura. Ainda foram realizados estudos da neurotransmissão glutamatérgica e com isso foi identificada uma diminuição na captação de glutamato em hipocampo e córtex nos camundongos MPS I, além de uma diminuição no binding para glutamato no hipocampo. Como conclusão desses estudos, foram desenvolvidos vetores eficientes para transferência do gene terapêutico e, adicionalmente, os danos fisiológicos causados pela doença no SNC foram melhor elucidados no modelo murino de MPS I. As informações obtidas aqui serão de grande importância principalmente quando associadas a ensaios de terapia gênica, pois as características encontradas no SNC podem ser usadas para acompanhamentos de ensaios préclínicos usando os vetores desenvolvidos no trabalho.Mucopolysaccharidosis type I (MPS I) is a monogenic disease resulting from a defect in the gene that encodes the lysosomal hydrolase a-L-iduronidase (IDUA) and characterized by accumulation of glycosaminoglycans (GAGs) heparan and dermatan sulfate. Phenotypic characteristics involve bone malformations, hepatosplenomegaly, heart problems, corneal opacity and mental retardation. Treatment of MPS I is currently based on enzymatic replacement and bone marrow transplantation. Since these treatments are not capable of correcting central nervous system (CNS) effects of the disease, new therapeutic approaches are needed. One of the problems in the investigation of MPS I is the paucity of studies about resulting physiological consequences, particularly those related to the CNS. Aiming to contribute to these aspects of MPS I, this study proposes (a) the development of three viral vectors to be used in gene therapy preclinical studies, and (b) the further investigation of physiopathological alterations in the CNS of a murine model of MPS I (MPS I mice). Three viral vectors, carrying the human IDUA gene, were produced. The vector based on the human immunodeficiency virus (HIV) was produced in low titers, but induced a 60-fold increase in the baseline activity of IDUA in transduced cells. A second vector, based on the Moloney murine leukemia virus (MoMLV), was capable to transduce mesenchymal stem cells isolated from the bone marrow of MPS I mice, representing an interesting tools for ex vivo gene therapy protocols. The third vector, was based on the feline immunodeficiency virus (FIV), was functionally inferior to the other two systems and needs optimization to be therapeutically useful. The model was characterized by the investigation of phosphorylation patterns of neurofilament proteins in different regions of the brain of MPS I mice. The results showed that, besides alterations in the direct phosphorylation profile of the proteins analyzed, ERK1/2 was hyperphosphorylated in the cortex and hippocampus. Ganglioside storage was individually investigated in the cortex, cerebellum, hippocampus and hypothalamus, and specific differences were observed for each structure. An analysis of glutamatergic neurotransmission was also performed. MPS I animals showed a decrease in the glutamate uptake in the cortex and hippocampus. In addition, glutamate binding was decreased in the hippocampus. In conclusion, the present work resulted in the development of efficient viral vectors for the transfer of the therapeutic gene, and CNS physiological damages due to the disease were characterized in the murine model of MPS I. These results will be of great importance particularly when associated to gene therapy trials, since the CNS characteristics described in this work may be used for the follow-up of preclinical assays with the viral vectors developed.
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DE, PONTI GIADA. "Exploring early therapeutic approaches in a Mucopolysaccharidosis type I (MPS I) mouse model." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/382061.
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In questo progetto di dottorato, sono stati presi in considerazione alcuni punti cruciali relativi alla malattia Mucopolisaccaridosi di tipo I (MPSI) e ai limiti delle attuali terapie, per migliorarle concentrandosi su approcci in epoca neonatale, a livello di combinazione terapeutiche (HSCT e ERT) e di terapia genica, e su riduzione delle tossicità associate ai regimi di condizionamento. Complessivamente, le problematiche più significative riguardo MPSI rimangono la necessità di un intervento precoce e rapido, l’incompleta correzione della malattia in seguito agli attuali approcci terapeutici e gli effetti collaterali dovuti al regime di precondizionamento. La prima parte del progetto si è concentrata sul testare un approccio terapeutico che combinasse i trattamenti canonici per MPSI. È stata testata l'efficacia della combinazione di HSCT ed ERT nel modello murino di MPSI come intervento neonatale, per valutare i benefici aggiuntivi della terapia enzimatica effettuata in modo continuativo a seguito del trapianto di cellule da donatore. Tre opzioni di trattamento sono state confrontate dalla nascita, considerando la mancante attività enzimatica (IDUA), l’accumulo di GAG e di vacuoli nei principali organi viscerali, la risposta nei confronti di IDUA ricombinante e i miglioramenti di tipo scheletrico e cerebrale. Pertanto, un approccio combinato di HSCT ed ERT nel periodo neonatale potrebbe essere applicato per migliorare alcune manifestazioni cliniche di MPSI, soprattutto evitando danni irreversibili. La seconda parte del progetto di dottorato è stata svolta in collaborazione con TIGET-SR e il Prof. Alessandro Aiuti. Si è concentrato sulla sperimentazione di un approccio di terapia genica neonatale in un modello murino di MPSI, considerando l'importanza di correggere precocemente la malattia. In particolare, abbiamo valutato se questo trattamento terapeutico potesse essere applicato nei neonati MPSI e potesse essere una strategia efficace per superare i principali problemi clinici che permangono dopo il trattamento canonico. Abbiamo valutato l'effetto della terapia genica somministrata nei neonati affetti da MPSI, monitorando i valori di IDUA e VCN nel sangue periferico e considerando infine la mancante attività enzimatica (IDUA), l’accumulo di GAG e di vacuoli nei principali organi viscerali, la risposta nei confronti di IDUA ricombinante e i miglioramenti di tipo scheletrico e cerebrale. Contemporaneamente, abbiamo cercato di ridurre gli effetti collaterali causati dal regime di condizionamento nel contesto delle terapie neonatali per MPSI, come progetto parallelo. L’obiettivo principale è stato trasporre l'applicazione di ADC, molecole congiunte di anticorpo-farmaco, capaci di agire specificatamente sulla cellula, come condizionamento per il trattamento neonatale di MPSI, in cui un intervento precoce è fondamentale. Poiché nessuna delle opzioni testate è stata in grado di indurre un sufficiente attecchimento di cellule del donatore da essere rilevante per il trattamento precoce dell'MPSI, ne abbiamo ricercato le cause, dimostrando la necessità di ulteriori studi prima dell'applicazione degli ADC nel modello studiato, in quelli umanizzati e nei cuccioli di MPSI NSG. Analisi preliminari sono state effettuate relativamente all’aumento dei livelli di citochine dopo CD117-SAP nei topi NSG adulti, confrontandoli agli altri regimi di condizionamento, per valutare una possibile applicazione di ADC con farmaci antinfiammatori prima della terapia precoce nei cuccioli MPSI.The present PhD project has taken into account critical issues around Mucopolysaccharidosis type I (MPSI) and limitations of current therapies to further improve them, by generally focusing on neonatal therapeutic approaches, both in terms of combined HSCT and ERT and of gene therapy, and on trying to reduce the overall toxicities associated with pre-conditioning settings. Overall, the most important open issues regarding this rare life-threatening disorder are the need for a precocious and rapid intervention, the lack of complete disease correction after current therapeutic approaches and side effects due to pre-conditioning regiment. My PhD project partially focused on testing a combined approach of the current standard-of-cares for treating MPSI. HSCT and ERT combination efficacy was tested in a mouse model of MPSI as neonatal intervention, for evaluating additional benefits of continuous enzyme therapy after transplant of donor’s cells. We compared three treatment options starting from MPSI pups’ birth, considering IDUA deficient activity, GAGs storage and vacuoles in visceral organs, the immune response against the recombinant IDUA and skeletal and CNS ameliorations. Therefore, performing a combined approach of HSCT and ERT in the neonatal period could help improving some hard-to-treat MPSI manifestations. The second part of this PhD project was carried out in collaboration with TIGET-SR and Prof. Alessandro Aiuti. It was focused on testing a neonatal gene therapy approach in a mouse model of MPSI, considering the importance of an early phenotype correction. In particular, we evaluated if this early treatment could be applied in MPSI neonates and could be a successful strategy for overcoming the main clinical issues that still remain after current canonical HSCT treatment. We monitored peripheral blood of treated mice for 8 months in terms of enzymatic activity and VCN, and we evaluated the effect of GT performed in MPSI pups at endpoint, considering IDUA deficient activity, vector copies/genome, GAGs storage and vacuoles in visceral organs, the immune response against the recombinant IDUA and skeletal and CNS ameliorations. The last part of this PhD project was centered on trying to reduce the high morbidity and mortality due to the severe conditioning regimen in the context of neonatal MPSI therapies, as a side project. The main objective was to translate the application of hematopoietic cell–specific antibody-drug conjugates (ADCs) as conditioning for early MPSI treatment, in which a precocious intervention is crucial. Since none of the tested setting was able to induce enough engraftment of donor’s cells to be relevant for MPSI early treatment, we tried to understand what could interfere, but we demonstrated the need for further studies prior to ADCs application in humanised models and in MPSI NSG pups. Preliminary results on increased cytokines levels after CD117-SAP in adult NSG compared to other conditioning settings were performed to evaluate impairment of inflammation and possible ADC application with anti-inflammatory drugs prior to early therapy in MPSI pups.
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Wu, Yong. "Relaxation Effects in Magnetic Nanoparticle Physics: MPI and MPS Applications." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1370865200.
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Junior, Jose Geraldo Goncalves de Oliveira. "Aspectos da dinâmica de emaranhamento em sistemas multipartidos e o interferômetro Mach-Zehnder com discriminador de que-caminho." Universidade Federal de Minas Gerais, 2011. http://hdl.handle.net/1843/MPSA-8NWLW5.
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We investigate aspects, in various contexts, of entanglement and the wave particle duality. We show that the dynamics of tripartite systems which interact via one excitation exchange leads to a direct connection between entanglement sudden death and the appearance of genuine entanglement. We also show that this is valid (not with the same generality) also for a four partite system in the context of the double JaynesCummings model. Moreover we show that the entanglement dynamics in this case can be completely expressed in geometrical terms. Using the same system we show that by performing adequate Zeno like measurements it is possible to freeze, increase, or even revive the initial entanglement. This intriguing result is also associated to entanglement sudden death. As far as wave particle duality and entanglement are concerned we studied a particle going through an interferometer equipped with a whichway device. We quantified the quality of the probe and exhibit its connection with the availability of the whichway information provided by the probe system. When the probe system information is unaccessible only the particle character will be observed. We obtain limits for a good (quantum regime) and for a bad (classical regime) whichway detector (probe system). We used our results to interpret a recent experiment set up to test the quantumclassical border where the probe covers from the quantum to the classical limit. We showed that the experimental errors influenced the conclusion inferred form the data about having achieved the classical limit. Finally we analyze the Ramsey zones from the point of view of our findings and provide for a transparent physical interpretation. In this case the classical limit of the probe system is reached due to a source plus strong dissipation dynamics, which swaps whichway information to a system containing an infinite number of degrees of freedom, making thus sure that any whichway information becomes unavailable.Nesta tese o emaranhamento e a dualidade ondapartida são os temas principais de estudo. Para examinar alguns dos aspectos e características do emaranhamento, analisamos sistemas de três e quatro partes constituídos por átomos e pelo campo eletromagnético. A interação átomocampo é dada pelo modelo de JaynesCummings. De início mostramos que existe uma ligação direta entre o emaranhamento residual e a morte súbita de emaranhamento quando a interação entre os sistemas é do tipo troca de excitações. Como extensão, estudamos um sistema dinâmico de quatro partes e mostramos que havendo morte súbita haverá um emaranhamento que não pode ser contabilizado apenas via o emaranhamento das bipartições. Estudamos ainda os aspectos geométricos relativos à dinâmica do emaranhamento e mostramos que existe uma manifestação geométrica da morte súbita. Na sequência, neste mesmo modelo de quatro partes, ao intervir na dinâmica com medidas tipo Zeno, mostramos que a dinâmica de emaranhamento é alterada e com isso tornase possível congelar, aumentar e reviver o emaranhamento. Contudo, a possibilidade de aumentar e reviver o emaranhamento está vinculada a existência de MSE em alguma partição. Fizemos ainda uma investigação sobre a dualidade ondapartícula considerando uma partícula quântica que atravessa um interferômetro equipado com um marcador de caminho. Neste trabalho, quantificamos a qualidade da ponta de prova e mostramos sua conexão com a quantidade de informação de quecaminho que ficou disponível. Percebemos que quando a ponta de prova é incapaz de disponibilizar a informação de quecaminho então será um sistema que possui apenas comportamento tipo corpúsculo. Encontramos limites para um bom (regime quântico) ou um mal (regime clássico) discriminador de quecaminho. Aplicamos nossos resultados a um experimento de complementaridade na borda quânticoclássico onde a ponta de prova transita do regime quântico ao clássico. Mostramos que as imperfeições experimentais influem na conclusão tirada acerca do limite clássico. Em seguida, analisamos as zonas de Ramsey onde nossos resultados fornecem uma simples interpretação. Neste caso, o limite clássico da ponta de prova é alcançado mediante a dinâmica fonte+dissipação que varre a informação de quecaminho e a leva para um sistema com infinitos graus de liberdade deixandoa completamente indisponível.
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Kamal, Humaira. "FG-MPI : Fine-Grain MPI." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44668.
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The Message Passing Interface (MPI) is widely used to write sophisticated parallel applications
ranging from cognitive computing to weather predictions and is almost universally
adopted for High Performance Computing (HPC).
Many popular MPI implementations bind MPI processes to OS-processes. This runtime
model has closely matched single or multi-processor compute clusters. Since 2008, however,
clusters of multicore nodes have been the predominant architecture for HPC, with the
opportunity for parallelism inside one compute node. There are a number of popular parallel
programming languages for multicore that use message passing. One notable difference
between MPI and these languages is the granularity of the MPI processes. Processes written
using MPI tend to be coarse-grained and designed to match the number of processes to the
available hardware, rather than the program structure. Binding MPI processes to OS-processes
fails to take full advantage of the finer-grain parallelism available on today's
multicore systems. Our goal was to take advantage of the type of runtime systems used by
fine-grain languages and integrate that into MPI to obtain the best of these programming
models; the ability to have fine-grain parallelism, while maintaining MPI's rich support for
communication inside clusters.
Fine-Grain MPI (FG-MPI) is a system that extends the execution model of MPI to
include interleaved concurrency through integration into the MPI middleware. FG-MPI
is integrated into the MPICH2 middleware, which is an open source, production-quality
implementation of MPI. The FG-MPI runtime uses coroutines to implement light-weight MPI processes that are non-preemptively scheduled by its MPI-aware scheduler. The use of
coroutines enables fast context-switching time and low communication and synchronization
overhead. FG-MPI enables expression of finer-grain function-level parallelism, which allows
for flexible process mapping, scalability, and can lead to better program performance.
We have demonstrated FG-MPI's ability to scale to over a 100 million MPI processes
on a large cluster of 6,480 cores. This is the first time any system has executed such a large
number of MPI processes, and this capability will be useful in exploring scalability issues of
the MPI middleware as systems move towards compute clusters with millions of processor
cores.
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Ramesh, Srinivasan. "MPI Performance Engineering with the MPI Tools Information Interface." Thesis, University of Oregon, 2018. http://hdl.handle.net/1794/23779.
Full textAbstract:
The desire for high performance on scalable parallel systems is increasing
the complexity and the need to tune MPI implementations. The MPI Tools
Information Interface (MPI T) introduced in the MPI 3.0 standard provides
an opportunity for performance tools and external software to introspect and
understand MPI runtime behavior at a deeper level to detect scalability issues. The
interface also provides a mechanism to fine-tune the performance of the MPI library
dynamically at runtime.
This thesis describes the motivation, design, and challenges involved in
developing an MPI performance engineering infrastructure using MPI T for two performance toolkits — the TAU Performance System, and Caliper. I validate the design of the infrastructure for TAU by developing optimizations
for production and synthetic applications. I show that the MPI T runtime
introspection mechanism in Caliper enables a meaningful analysis of performance
data.
This thesis includes previously published co-authored material.
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Massetto, Francisco Isidro. "Hybrid MPI - uma implementação MPI para ambientes distribuídos híbridos." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/3/3141/tde-08012008-100937/.
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O crescente desenvolvimento de aplicações de alto desempenho é uma realidade presente nos dias atuais. Entretanto, a diversidade de arquiteturas de máquinas, incluindo monoprocessadores e multiprocessadores, clusters com ou sem máquina front-end, variedade de sistemas operacionais e implementações da biblioteca MPI tem aumentado cada dia mais. Tendo em vista este cenário, bibliotecas que proporcionem a integração de diversas implementações MPI, sistemas operacionais e arquiteturas de máquinas são necessárias. Esta tese apresenta o HyMPI, uma implementação da biblioteca MPI voltada para integração, em um mesmo ambiente distribuído de alto desempenho, nós com diferentes arquiteturas, clusters com ou sem máquina front-end, sistemas operacionais e implementações MPI. HyMPI oferece um conjunto de primitivas compatíveis com a especificação MPI, incluindo comunicação ponto a ponto, operações coletivas, inicio e termino, além de outras primitivas utilitárias.The increasing develpment of high performance applications is a reality on current days. However, the diversity of computer architectures, including mono and multiprocessor machines, clusters with or without front-end node, the variety of operating systems and MPI implementations has growth increasingly. Focused on this scenario, programming libraries that allows integration of several MPI implementations, operating systems and computer architectures are needed. This thesis introduces HyMPI, a MPI implementation aiming integratino, on a distributed high performance system nodes with different architectures, clusters with or without front-end machine, operating systems and MPI implementations. HyMPI offers a set of primitives based on MPI specification, including point-to-point communication, collective operations, startup and finalization and some other utility functions.
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Johansson, Björn, Bahaa Alashi, and Mikael Ekström. "MPS i molnet." Thesis, Tekniska Högskolan, Högskolan i Jönköping, JTH, Data- och elektroteknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-23685.
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Husni, Emir Mauludi. "Robust Reed Solomon coded MPSK modulation." Thesis, University of Surrey, 1997. http://epubs.surrey.ac.uk/844198/.
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Much work has been done on design of efficient coded modulation schemes since the publication of [Ungerboeck, 1982] for trellis coded modulation and [Imai & Hirakawa, 1977] for block coded modulation. Recently, increasing interest in digital mobile radio and indoor wireless systems has led to the consideration of coded modulation designs for combating fading channels. In this research, it is intended to present results of an investigation of the construction of Reed Solomon coded MPSK modulation which is robust for the Gaussian channel and a Rayleigh fading channel. Two approaches have been applied to Reed Solomon coded modulation. First, a Reed Solomon code was combined with MPSK signal set using Gray code mapping; this was called Reed Solomon coded modulation not based on set partitioning. This approach was the baseline scheme which would be compared with the proposed approach, namely Reed Solomon coded modulation based on set partitioning. The second approach to coded MPSK with M = 2m was multilevel Reed Solomon coding. In this case, each of the m bits defining an MPSK symbol was coded and decoded by different Reed Solomon codecs. The set partitioning principle was applied to define subsets with distances Deltai,-, (i = 1 to m) that were nondecreasing with i. Each of the m bits defined a subset and was decoded in multistage decoding schemes. The novel idea here was that in the receiver, we used a rotated 2m+1-PSK detector if the transmitter used a 2m-PSK modulator. The designs of Reed Solomon coded modulation schemes for the Gaussian channel and a Rayleigh fading channel (i.e. choice of the code configurations which were suitable for this channel) have been studied. The performance of Reed Solomon coded modulation based on set partitioning was compared with Reed Solomon coded modulation not based on set-partitioning, then with multilevel Reed Solomon coded modulation using Gray mapping and finally with coded modulation schemes using binary codes, Reed Muller codes. It has been shown that over the Gaussian channel and a Rayleigh fading channel, Reed Solomon coded modulation based on set partitioning is better than several alternatives, such as schemes not based on set partitioning, multistage Reed Solomon coded modulation based on Gray mapping and Reed Muller coded modulation. It was found that good codes for a Rayleigh fading channel have configurations in which all component codes have the same minimum Hamming distance because the fading phase is uniformly distributed random process. Therefore, by matching configurations of component codes with the channel characteristics, it was shown that Reed Solomon coded modulation based on set partitioning was robust for the Gaussian and a Rayleigh fading channel. Reed Solomon coded modulation schemes were applied to Orthogonal Frequency Division Multiplexing (OFDM) transmissions. The main disadvantage of OFDM systems is that they have high Peak-to-Mean Envelope Power Ratio (PMEPR). A scheme for reducing the PMEPR of OFDM systems was investigated. Multiphase complementary code pairs of length 2 are proposed to reduce the PMEPR of MPSK and QAM OFDM. Concatenated codes with Reed Solomon coded modulation as an inner code and an RS(511, 443) code as an outer code are proposed as coding schemes for OFDM systems.
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Subotic, Vladimir. "Evaluating techniques for parallelization tuning in MPI, OmpSs and MPI/OmpSs." Doctoral thesis, Universitat Politècnica de Catalunya, 2013. http://hdl.handle.net/10803/129573.
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Parallel programming is used to partition a computational problem among multiple processing units and to define how they interact (communicate and synchronize) in order to guarantee the correct result. The performance that is achieved when executing the parallel program on a parallel architecture is usually far from the optimal: computation unbalance and excessive interaction among processing units often cause lost cycles, reducing the efficiency of parallel computation.
In this thesis we propose techniques oriented to better exploit parallelism in parallel applications, with emphasis in techniques that increase asynchronism. Theoretically, this type of parallelization tuning promises multiple benefits. First, it should mitigate communication and synchronization delays, thus increasing the overall performance. Furthermore, parallelization tuning should expose additional parallelism and therefore increase the scalability of execution. Finally, increased asynchronism would provide higher tolerance to slower networks and external noise.
In the first part of this thesis, we study the potential for tuning MPI parallelism. More specifically, we explore automatic techniques to overlap communication and computation. We propose a speculative messaging technique that increases the overlap and requires no changes of the original MPI application. Our technique automatically identifies the application’s MPI activity and reinterprets that activity using optimally placed non-blocking MPI requests. We demonstrate that this overlapping technique increases the asynchronism of MPI messages, maximizing the overlap, and consequently leading to execution speedup and higher tolerance to bandwidth reduction. However, in the case of realistic scientific workloads, we show that the overlapping potential is significantly limited by the pattern by which each MPI process locally operates on MPI messages.
In the second part of this thesis, we study the potential for tuning hybrid MPI/OmpSs parallelism. We try to gain a better understanding of the parallelism of hybrid MPI/OmpSs applications in order to evaluate how these applications would execute on future machines and to predict the execution bottlenecks that are likely to emerge. We explore how MPI/OmpSs applications could scale on the parallel machine with hundreds of cores per node. Furthermore, we investigate how this high parallelism within each node would reflect on the network constraints. We especially focus on identifying critical code sections in MPI/OmpSs. We devised a technique that quickly evaluates, for a given MPI/OmpSs application and the selected target machine, which code section should be optimized in order to gain the highest performance benefits.
Also, this thesis studies techniques to quickly explore the potential OmpSs parallelism inherent in applications. We provide mechanisms to easily evaluate potential parallelism of any task decomposition. Furthermore, we describe an iterative trialand-error approach to search for a task decomposition that will expose sufficient parallelism for a given target machine.
Finally, we explore potential of automating the iterative approach by capturing the programmers’ experience into an expert system that can autonomously lead the search process. Also, throughout the work on this thesis, we designed development tools that can be useful to other researchers in the field. The most advanced of these tools is Tareador – a tool to help porting MPI applications to MPI/OmpSs programming model. Tareador provides a simple interface to propose some decomposition of a code into OmpSs tasks. Tareador dynamically calculates data dependencies among the annotated tasks, and automatically estimates the potential OmpSs parallelization. Furthermore, Tareador gives additional hints on how to complete the process of porting the application to OmpSs. Tareador already proved itself useful, by being included in the academic classes on parallel programming at UPC.La programación paralela consiste en dividir un problema de computación entre múltiples unidades de procesamiento y definir como interactúan (comunicación y sincronización) para garantizar un resultado correcto. El rendimiento de un programa paralelo normalmente está muy lejos de ser óptimo: el desequilibrio de la carga computacional y la excesiva interacción entre las unidades de procesamiento a menudo causa ciclos perdidos, reduciendo la eficiencia de la computación paralela. En esta tesis proponemos técnicas orientadas a explotar mejor el paralelismo en aplicaciones paralelas, poniendo énfasis en técnicas que incrementan el asincronismo. En teoría, estas técnicas prometen múltiples beneficios. Primero, tendrían que mitigar el retraso de la comunicación y la sincronización, y por lo tanto incrementar el rendimiento global. Además, la calibración de la paralelización tendría que exponer un paralelismo adicional, incrementando la escalabilidad de la ejecución. Finalmente, un incremente en el asincronismo proveería una tolerancia mayor a redes de comunicación lentas y ruido externo. En la primera parte de la tesis, estudiamos el potencial para la calibración del paralelismo a través de MPI. En concreto, exploramos técnicas automáticas para solapar la comunicación con la computación. Proponemos una técnica de mensajería especulativa que incrementa el solapamiento y no requiere cambios en la aplicación MPI original. Nuestra técnica identifica automáticamente la actividad MPI de la aplicación y la reinterpreta usando solicitudes MPI no bloqueantes situadas óptimamente. Demostramos que esta técnica maximiza el solapamiento y, en consecuencia, acelera la ejecución y permite una mayor tolerancia a las reducciones de ancho de banda. Aún así, en el caso de cargas de trabajo científico realistas, mostramos que el potencial de solapamiento está significativamente limitado por el patrón según el cual cada proceso MPI opera localmente en el paso de mensajes. En la segunda parte de esta tesis, exploramos el potencial para calibrar el paralelismo híbrido MPI/OmpSs. Intentamos obtener una comprensión mejor del paralelismo de aplicaciones híbridas MPI/OmpSs para evaluar de qué manera se ejecutarían en futuras máquinas. Exploramos como las aplicaciones MPI/OmpSs pueden escalar en una máquina paralela con centenares de núcleos por nodo. Además, investigamos cómo este paralelismo de cada nodo se reflejaría en las restricciones de la red de comunicación. En especia, nos concentramos en identificar secciones críticas de código en MPI/OmpSs. Hemos concebido una técnica que rápidamente evalúa, para una aplicación MPI/OmpSs dada y la máquina objetivo seleccionada, qué sección de código tendría que ser optimizada para obtener la mayor ganancia de rendimiento. También estudiamos técnicas para explorar rápidamente el paralelismo potencial de OmpSs inherente en las aplicaciones. Proporcionamos mecanismos para evaluar fácilmente el paralelismo potencial de cualquier descomposición en tareas. Además, describimos una aproximación iterativa para buscar una descomposición en tareas que mostrará el suficiente paralelismo en la máquina objetivo dada. Para finalizar, exploramos el potencial para automatizar la aproximación iterativa. En el trabajo expuesto en esta tesis hemos diseñado herramientas que pueden ser útiles para otros investigadores de este campo. La más avanzada es Tareador, una herramienta para ayudar a migrar aplicaciones al modelo de programación MPI/OmpSs. Tareador proporciona una interfaz simple para proponer una descomposición del código en tareas OmpSs. Tareador también calcula dinámicamente las dependencias de datos entre las tareas anotadas, y automáticamente estima el potencial de paralelización OmpSs. Por último, Tareador da indicaciones adicionales sobre como completar el proceso de migración a OmpSs. Tareador ya se ha mostrado útil al ser incluido en las clases de programación de la UPC.
Books on the topic "MPSI"
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de, Jacques Mesple. Chimie MPSI. Rosny-sous-Bois: Bre al e d., 2003.
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Rosset, G. Électrocinétique: MPSI. Rosny-sous-Bois [France]: Bréal, 2003.
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Cousin, Thibaut. Physique: MPSI, PTSI. 2nd ed. Paris: Dunod, 2011.
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Chemin, Alexandre. Chimie, MPSI-PCSI-PTSI. Paris: Ellipses, 2004.
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Langet, Raphaële. Électromagnétisme: PCSI, MPSI, PTSI. [Paris]: Nathan, 2007.
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Gendreau, Bernard. Électrocinétique, PCSI, MPSI, PTSI. [Paris]: Nathan, 2006.
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Marie, Allano-Chevalier, ed. Algèbre, géométrie, 1re année MPSI. Paris: Hachette supérieur, 1998.
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Nordin, Abu Bakar. Meniti zaman: STIC, MPSI, IPSI, UPSI. [Kuala Lumpur: Pustaka Antara Books, 2001.
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Poineau, Jérôme, (1980- ...)., Auteur, ed. Mathématiques: Exercices incontournables : MPSI-PCSI-PTSI. Paris: Dunod, 2010.
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Monier, Jean-Marie. Les méthodes et exercices de mathématiques MPSI. Paris: Dunod, 2008.
Find full textBook chapters on the topic "MPSI"
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Ross, Robert, Robert Latham, William Gropp, Ewing Lusk, and Rajeev Thakur. "Processing MPI Datatypes Outside MPI." In Recent Advances in Parallel Virtual Machine and Message Passing Interface, 42–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-03770-2_11.
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Ho, Joseph K. K. "MPSB Frameworks Explained." In Critical Issues in Systems Theory and Practice, 487–92. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4757-9883-8_73.
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Jongmans, Sung-Shik, and Nobuko Yoshida. "Exploring Type-Level Bisimilarity towards More Expressive Multiparty Session Types." In Programming Languages and Systems, 251–79. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44914-8_10.
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AbstractA key open problem with multiparty session types (MPST) concerns their expressiveness: current MPST have inflexible choice, no existential quantification over participants, and limited parallel composition. This precludes many real protocols to be represented by MPST. To overcome these bottlenecks of MPST, we explore a new technique using weak bisimilarity between global types and endpoint types, which guarantees deadlock-freedom and absence of protocol violations. Based on a process algebraic framework, we present well-formed conditions for global types that guarantee weak bisimilarity between a global type and its endpoint types and prove their check is decidable. Our main practical result, obtained through benchmarks, is that our well-formedness conditions can be checked orders of magnitude faster than directly checking weak bisimilarity using a state-of-the-art model checker.
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Knoth, Adrian. "Open MPI." In Grid-Computing, 117–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-79747-0_6.
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Huang, Chao, Orion Lawlor, and L. V. Kalé. "Adaptive MPI." In Languages and Compilers for Parallel Computing, 306–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-24644-2_20.
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Miller, William L., Stephen White, and Paul Heywood. "Entrepreneurial MPs." In Values and Political Change in Postcommunist Europe, 177–90. London: Palgrave Macmillan UK, 1998. http://dx.doi.org/10.1057/9780230377448_11.
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Padua, David, Amol Ghoting, John A. Gunnels, Mark S. Squillante, José Meseguer, James H. Cownie, Duncan Roweth, et al. "MPI-IO." In Encyclopedia of Parallel Computing, 1191–99. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-0-387-09766-4_297.
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Baliga, B. Jayant. "MPS Rectifiers." In Advanced Power Rectifier Concepts, 195–286. Boston, MA: Springer US, 2009. http://dx.doi.org/10.1007/978-0-387-75589-2_7.
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Mayer, Barbara, and Eva Maria Neubauer. "MPS Workstation." In Interaktive Lehre des Ingenieursstudiums, 271–90. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-56224-6_13.
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Oette, Mark, Marvin J. Stone, Hendrik P. N. Scholl, Peter Charbel Issa, Monika Fleckenstein, Steffen Schmitz-Valckenberg, Frank G. Holz, et al. "MPS IH." In Encyclopedia of Molecular Mechanisms of Disease, 1355. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_6301.
Full textConference papers on the topic "MPSI"
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Hu, Keji, and Wensheng Zhang. "mPSI: Many-to-one Private Set Intersection." In 2017 IEEE 4th International Conference on Cyber Security and Cloud Computing (CSCloud). IEEE, 2017. http://dx.doi.org/10.1109/cscloud.2017.35.
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Yang, Changjiang, Shuliang Huang, and Jingxiang Zhan. "Bleed and Feed Analysis for Loss of Secondary Heat Sink to Support the Development of EOPs." In 2018 26th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icone26-81933.
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The loss of secondary heat sink accident caused by loss of all feed water for a PWR with medium pressure safety injection system (MPSI) design is analyzed in order to support the development of one of the emergency operating procedures (EOPs), “response to loss of secondary heat sink”. The bleed and feed (B-F) measure to mitigate the accident is analyzed in detail. For the bleed and feed measure, the safety injection flow is established only after the reactor coolant system (RCS) pressure is lower than the pump head of MPSI, which needs the open of the pressurizer (PRZ) safety valves to depressurize the RCS ahead. To prevent the core uncovery or minimize the fuel cladding temperature during the bleed and feed process, the time and the number of PRZ safety valves needed to be opened are investigated. A best estimated plant model with RELAP5 code is applied for the sequences calculation. The result shows that the core water level and fuel cladding temperature will be benefited from an earlier open of all safety valves.
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Laya, K. P. "The Mechanical Stratigraphy of Kerendan Field in Upper Kutai Basin: Implication to Field Development with Massive Carbonate Tight Gas Reservoir." In Indonesian Petroleum Association 44th Annual Convention and Exhibition. Indonesian Petroleum Association, 2021. http://dx.doi.org/10.29118/ipa21-g-300.
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Understanding of field mechanical stratigraphy in terms of formation behavior due to coupled interaction between formation pressure depletion and state of stresses is crucial to achieving successful field development. These provide technical advantages of having a solid foundation for implementation in advanced well construction and completion strategy, especially in light of emerging and challenging plays related to unconventional reservoirs. This paper describes full-field interaction between formation behavior in 4D Geomechanical analysis of Kerendan Field located in Upper Kutai Basin, Central Kalimantan area on gas-condensate production from massive carbonate tight gas reservoir. Integrated 1D/3D/4D geomechanics study workflow result has enabled characterization of each mechanical stratigraphy unit, as follows: The overburden section is comprised of Miocene deltaic clastic succession which is characterized as “soft formation” with low stiffness (Static Young’s Modulus of 0.5 to 1.8 Mpsi) and low - medium rock strength (UCS of 800 to 2000 psi); Reservoir section comprised of Oligocene tight carbonates platform which characterized as “hard formation” with medium stiffness (Static Young’s Modulus of 3.0 to 4.5 Mpsi) and medium rock strength (UCS of 5000 to 6900 psi); Underburden section comprised of Eocene mixed-carbonate clastic succession and Pre-Tertiary metasediments which characterized as “very hard formation” with high stiffness (Static Young’s Modulus of 4.5 to 5.0 Mpsi) and medium rock strength (UCS of 6500 to 7900 psi). The Kerendan field would require implementation of special drilling and stimulation techniques in order to achieve optimum full field development potential owing to its reservoir characteristics. The field’s exhibit a large areal extent and massive tight limestone reservoir with relatively high Young’s Modulus, which is favorable for the utilization of extended reach drill (ERD) / horizontal wells followed with multi-stage acid fracturing stimulation. 3D/4D Geomechanical analysis is essential to assess the drillability and engineering limits of various development scenarios which will be strongly controlled by geomechanical fabric, pre-existing deformation/local discontinuities, prevailing principal stress tensor and stress changes during field production.
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Seck, Ayoub, Constantin S. E. Bassene, Sire Eugene Zabolo, and Samuel Ouya. "Building an interactive Software Defined Network from the MPSI for MPLS Service provisioning with Gitlab and Ansible." In 2022 International Conference on Electrical, Computer, Communications and Mechatronics Engineering (ICECCME). IEEE, 2022. http://dx.doi.org/10.1109/iceccme55909.2022.9988003.
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Li, Xin, Akifumi Yamaji, Masahiro Furuya, Ikken Sato, Hiroshi Madokoro, and Yuji Ohishi. "Preliminary Evaluation on the Relocation Phase of Ex-Vessel Debris of Fukushima Daiichi Nuclear Power Plant Unit-3." In 2021 28th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/icone28-64540.
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Abstract To deepen our understanding for the current debris status and investigate the debris-structure interactions in the pedestal region of Fukushima Unit-3, the Moving Particle Semi-implicit (MPS) method is further developed for simulation of multi-component liquid/solid relocation with solid-liquid phase changes aiming for plant-scale practices. The improvement of the existing MPS method mainly consists of two parts, namely 1) the improvement of numerical stability and accuracy, including a) applying second-order corrective matrix to the particle interaction models and b) particle shifting that can optimize particle configurations; and 2) improvement of calculation efficiency, including a) hybrid OpenMP and MPI parallelization and b) particle type-dependent speed-up algorithms to reduce calculation costs for particles with extremely high viscosity and low velocity. In the current study, the improved MPS method is validated against the experiments carried out at Waseda University, in which molten salt droplets were released to interact with aluminum pillars and solidify on them. Good agreement of the total height of the solidified salt and its distribution on the pillars has been achieved. The successful validation has shown the capability of the current MPS method for simulations of Unit-3 pedestal region.
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Daiguji, Hirofumi. "Transport and Adsorption Phenomena in Mesoporous Silica." In ASME 2012 10th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2012 Heat Transfer Summer Conference and the ASME 2012 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/icnmm2012-73137.
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The analysis and control of transport phenomena in fluidic nanopores and nanochannels is important in applications such as biochemical analysis, power generation and environmental protection. A unique aspect of nanofluidics is that the relevant length scale is comparable to the range of various surface and interfacial forces in liquids (such as electrostatic, van der Waals and steric interactions). Thus, to obtain an adequate description of transport phenomena in nanospace, it is necessary to understand the discreteness of molecules, especially when the size decreases to 2 nm. Micelle-templated mesoporous silicas (MPSs) possess highly ordered structures such as 2D hexagonal and 3D cubic structures and pores within the 2–50 nm range. In particular, 2D hexagonal films that generally have pore channels parallel to the surface plane have been widely synthesized by using various types of template molecules. If the pore channels of such materials are aligned in a certain direction, these materials can be employed for various purposes such as the fabrication of oriented nanowires, optoelectronic devices, recording media, selective separations, and nanofluidic systems. 3D cubic structures give large surface areas and become good candidates for highly efficient catalysts and sensors. Advances in the synthesis, measurement and analysis of nanotubes and nanochannels have allowed ion and liquid transport to be routinely examined and controlled in spaces with dimensions that range from 10 to 100 nm. The ability to now explore transport and adsorption phenomena in confined spaces of around 2 nm offers a range of possibilities. We have investigated several unique transport and adsorption phenomena in mesopores measuring a few nanometers in diameter, including nonlinear I–V curves of ionic current passing through MPS thin films filled with aqueous solutions, humidity-dependent adsorption rate of water into MPS, and the reduction of melting and freezing temperature of water in MPS.
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Lowa, N., P. Radon, F. Wiekhorst, D. Eberbeck, O. Kosch, R. August, and L. Trahms. "Online coupling of hydrodynamic fractionation with DLS, MALLS and MPS for MPI tracer evaluation." In 2015 5th International Workshop on Magnetic Particle Imaging (IWMPI). IEEE, 2015. http://dx.doi.org/10.1109/iwmpi.2015.7107001.
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Getov, Vladimir, Paul Gray, and Vaidy Sunderam. "MPI and Java-MPI." In the 1999 ACM/IEEE conference. New York, New York, USA: ACM Press, 1999. http://dx.doi.org/10.1145/331532.331553.
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Green, Ronald W. "Beyond MPI---Beyond MPI." In the 2006 ACM/IEEE conference. New York, New York, USA: ACM Press, 2006. http://dx.doi.org/10.1145/1188455.1188494.
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Wisniewski, Len, Brad Smisloff, and Nils Nieuwejaar. "Sun MPII/O." In the 1999 ACM/IEEE conference. New York, New York, USA: ACM Press, 1999. http://dx.doi.org/10.1145/331532.331546.
Full textReports on the topic "MPSI"
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Hassanzadeh, Sara, Sina Neshat, Afshin Heidari, and Masoud Moslehi. Myocardial Perfusion Imaging in the Era of COVID-19. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0063.
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Review question / Objective: This review studies all aspects of myocardial perfusion imaging with single-photon emission computed tomography (MPI SPECT) after the COVID-19 pandemic. Condition being studied: Many imaging modalities have been reduced after the COVID-19 pandemic. Our focus in this review is to see if the number of MPIs is lowered or not and, if so, why. Furthermore, it is possible that a combination of CT attenuation correction and MPI could yield findings. In this study, we'll also look for these probable findings. Third, we know from previous studies that COVID might cause cardiac injuries in some people. Since MPI is a cardiovascular imaging technique, it might shows those injuries. So we'll review articles to find out in patients with active COVID infection, long COVID, or previous COVID cases what findings in MPI those cardiac injuries can cause.
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Han, D., and T. Jones. MPI Profiling. Office of Scientific and Technical Information (OSTI), February 2005. http://dx.doi.org/10.2172/15014654.
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Garrett, Charles Kristopher. Distributed Computing (MPI). Office of Scientific and Technical Information (OSTI), June 2016. http://dx.doi.org/10.2172/1258356.
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Pritchard, Howard Porter Jr, Samuel Keith Gutierrez, Nathan Hjelm, Daniel Holmes, and Ralph Castain. MPI Sessions: Second Demonstration and Evaluation of MPI Sessions Prototype. Office of Scientific and Technical Information (OSTI), September 2019. http://dx.doi.org/10.2172/1566099.
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Pritchard, Howard. MPI Sessions - Working Group activities post MPI 4.0 standard ratification. Office of Scientific and Technical Information (OSTI), December 2022. http://dx.doi.org/10.2172/1906014.
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Loewe, W. MPI I/O Testing Results. Office of Scientific and Technical Information (OSTI), September 2007. http://dx.doi.org/10.2172/925675.
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George, William L., John G. Hagedorn, and Judith E. Devaney. Parallel programming with interoperable MPI. Gaithersburg, MD: National Institute of Standards and Technology, 2003. http://dx.doi.org/10.6028/nist.ir.7066.
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Light, Max Eugene. MPS and Ionospheric Propagation Codes. Office of Scientific and Technical Information (OSTI), February 2017. http://dx.doi.org/10.2172/1342887.
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Pritchard, Howard, and Tom Herschberg. MPI Session:External Network Transport Implementation. Office of Scientific and Technical Information (OSTI), September 2020. http://dx.doi.org/10.2172/1669081.
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Rao, Lakshman A., and Jon Weissman. MPI-Based Adaptive Parallel Grid Services. Fort Belvoir, VA: Defense Technical Information Center, August 2003. http://dx.doi.org/10.21236/ada439405.
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