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Journal articles on the topic 'MPC'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Firsov, Alexander A., Elena N. Strukova, Darya S. Shlykova, et al. "Bacterial Resistance Studies UsingIn VitroDynamic Models: the Predictive Power of the Mutant Prevention and Minimum Inhibitory Antibiotic Concentrations." Antimicrobial Agents and Chemotherapy 57, no. 10 (2013): 4956–62. http://dx.doi.org/10.1128/aac.00578-13.

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ABSTRACTIn light of the concept of the mutant selection window, i.e., the range between the MIC and the mutant prevention concentration (MPC), MPC-related pharmacokinetic indices should be more predictive of bacterial resistance than the respective MIC-related indices. However, experimental evidence of this hypothesis remains limited and contradictory. To examine the predictive power of the ratios of the area under the curve (AUC24) to the MPC and the MIC, the selection of ciprofloxacin-resistant mutants of fourEscherichia colistrains with different MPC/MIC ratios was studied. Each organism wa

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Strukova, Elena N., Yury A. Portnoy, Andrey V. Romanov, Mikhail V. Edelstein, Stephen H. Zinner, and Alexander A. Firsov. "Searching for the Optimal Predictor of Ciprofloxacin Resistance in Klebsiella pneumoniae by UsingIn VitroDynamic Models." Antimicrobial Agents and Chemotherapy 60, no. 3 (2015): 1208–15. http://dx.doi.org/10.1128/aac.02334-15.

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There is growing evidence of applicability of the hypothesis of the mutant selection window (MSW), i.e., the range between the MIC and the mutant prevention concentration (MPC), within which the enrichment of resistant mutants is most probable. However, it is not clear if MPC-based pharmacokinetic variables are preferable to the respective MIC-based variables as interstrain predictors of resistance. To examine the predictive power of the ratios of the area under the curve (AUC24) to the MPC and to the MIC, the selection of ciprofloxacin-resistant mutants of threeKlebsiella pneumoniaestrains wi

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Meena, Lakshmipathy, Krishnan Selvi, A. V. Kavitha, Sunderesan Anand, and Durgadevi Parthasarathy. "A pilot study on comparative analysis of minimum inhibitory concentration and mutant prevention concentration of conjunctival bacterial isolates against fluoroquinolones." Indian Journal of Microbiology Research 11, no. 3 (2024): 180–85. http://dx.doi.org/10.18231/j.ijmr.2024.033.

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The aim of this study was to compare the Minimum Inhibitory Concentration (MIC) and Mutant Prevention Concentration (MPC) of fluoroquinolones, including ciprofloxacin, moxifloxacin, and gatifloxacin, against and coagulase-negative Staphylococci (CONS) isolated from conjunctival swabs.25 isolates of spp., obtained from conjunctival swabs submitted to the Department of Microbiology, Vision Research Foundation, Sankara Nethralaya, were included in this study. The identification and confirmation of spp. were performed using standard microbiological techniques. The MIC and MPC were determined using

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Palupi, Maria Fatima, Eli Nugraha, Meutia Hayati, and Neneng Atikah. "Mutant Prevention Concentration Siprofloksasin Terhadap Escherichia coli Patogen dari Kloaka Broiler Secara In Vitro." Jurnal Sain Veteriner 39, no. 1 (2021): 20. http://dx.doi.org/10.22146/jsv.57040.

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Mutant prevention concentration (MPC) is an in vitro test used to determine the lowest drug concentration needed to inhibit the growth of a single-step-mutant bacterial subpopulation. The purpose of this study was to determine the MPC value of ciprofloxacin against pathogenic Escherichia coli to obtained the range of mutant selection windows (MSW) of ciprofloxacin. Ciprofloxacin is a quinolone group that is included in the Highest Priority Critically Important Antimicrobials for Human Medicine but is also used for the treatment of bacterial infections in production animals. Twenty-four of path

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Salunke, Prafulla, and Lloyd E. Metzger. "Transglutaminase Crosslinked Milk Protein Concentrate and Micellar Casein Concentrate: Impact on the Functionality of Imitation Mozzarella Cheese Manufactured on a Small Scale Using a Rapid Visco Analyzer." Foods 13, no. 17 (2024): 2720. http://dx.doi.org/10.3390/foods13172720.

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In dairy-based imitation mozzarella cheese (IMC) formulations, intact casein is critical and imparts IMC with a firm and elastic, stringy, melted texture. Rennet casein (RCN) is the desired ingredient to provide intact casein in IMC and is preferred over milk protein concentrate (MPC) and micellar casein concentrate (MCC). Transglutaminase (TGase), a crosslinking enzyme, alters the physical properties of MPC or MCC and may change IMC functionality. The objective of this study was to determine the effect of TGase-crosslinked MPC and MCC powders on the functionality of IMCs. The TGase treatment

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Firsov, Alexander A., Maria V. Golikova, Elena N. Strukova, et al. "In VitroResistance Studies with Bacteria That Exhibit Low Mutation Frequencies: Prediction of “Antimutant” Linezolid Concentrations Using a Mixed Inoculum Containing both Susceptible and Resistant Staphylococcus aureus." Antimicrobial Agents and Chemotherapy 59, no. 2 (2014): 1014–19. http://dx.doi.org/10.1128/aac.04214-14.

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ABSTRACTBacterial resistance studies usingin vitrodynamic models are highly dependent on the starting inoculum that might or might not contain spontaneously resistant mutants (RMs). To delineate concentration-resistance relationships with linezolid-exposedStaphylococcus aureus, a mixed inoculum containing both susceptible cells and RMs was used. An RM selected after the 9th passage of the parent strain (MIC, 2 μg/ml) on antibiotic-containing media (RM9; MIC, 8 μg/ml) was chosen for the pharmacodynamic studies, because the mutant prevention concentration (MPC) of linezolid against the parent st

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Guan, Weide, Shoudao Huang, Derong Luo, and Fei Rong. "A Reverse Model Predictive Control Strategy for a Modular Multilevel Converter." Energies 12, no. 2 (2019): 297. http://dx.doi.org/10.3390/en12020297.

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In recent years, modular multilevel converters (MMCs) have developed rapidly, and are widely used in medium and high voltage applications. Model predictive control (MPC) has attracted wide attention recently, and its advantages include straightforward implementation, fast dynamic response, simple system design, and easy handling of multiple objectives. The main technical challenge of the conventional MPC for MMC is the reduction of computational complexity of the cost function without the reduction of control performance of the system. Some modified MPC scan decrease the computational complexi

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Serrano-Rodríguez, J. M., C. Cárceles-García, C. M. Cárceles-Rodríguez, M. L. Gabarda, J. M. Serrano-Caballero, and E. Fernández-Varón. "Susceptibility and PK/PD relationships of Staphylococcus aureus strains isolated from the milk of sheep and goats with clinical mastitis to five veterinary fluoroquinolones." Veterinary Record 180, no. 15 (2017): 376. http://dx.doi.org/10.1136/vr.103964.

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Minimum inhibitory concentration (MIC) and mutant prevention concentration (MPC) of veterinary fluoroquinolones as enrofloxacin, its metabolite ciprofloxacin, danofloxacin, difloxacin and marbofloxacin against Staphylococcus aureus strains (n=24) isolated from milk of sheep and goats affected by clinical mastitis were evaluated. The authors have used the MIC and MPC, as well as the pharmacokinetic-pharmacodynamic relationships in plasma and milk. MIC values were significantly different between drugs, unlike MPC values. Lower MIC values were obtained for danofloxacin and difloxacin, middle and

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Chen, Lianghua, Jianping Zhou, Jiayu Zhai, Lisheng Yang, Xudong Qian, and Zhiyong Tao. "Continuous-Control-Set Model Predictive Control Strategy for MMC-UPQC Under Non-Ideal Conditions." Energies 18, no. 11 (2025): 2946. https://doi.org/10.3390/en18112946.

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In the MMC-based unified power quality conditioner (MMC-UPQC), the computational burden of finite-control-set model predictive control (FCS-MPC) increases rapidly with the number of MMC submodules. Meanwhile, conventional linear and nonlinear control methods suffer from limited compensation accuracy. To address this, a control strategy combining continuous-control-set model predictive control (CCS-MPC) and phase-shifted carrier pulse-width modulation (PSC-PWM) is proposed. CCS-MPC performs repeated time-domain optimization based on the system model. It offers advantages such as fast dynamic re

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Credito, Kim, Klaudia Kosowska-Shick, and Peter C. Appelbaum. "Mutant Prevention Concentrations of Four Carbapenems against Gram-Negative Rods." Antimicrobial Agents and Chemotherapy 54, no. 6 (2010): 2692–95. http://dx.doi.org/10.1128/aac.00033-10.

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ABSTRACT We tested the propensities of four carbapenems to select for resistant Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii mutants by determining the mutant prevention concentrations (MPCs) for 100 clinical strains with various ß-lactam phenotypes. Among the members of the Enterobacteriaceae family and A. baumannii strains, the MPC/MIC ratios were mostly 2 to 4. In contrast, for P. aeruginosa the MPC/MIC ratios were 4 to ≥16. The MPC/MIC ratios for β-lactamase-positive K. pneumoniae and E. coli isolates were much higher (range, 4 to >16 μg/m

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Liang, Beibei, Nan Bai, Yun Cai, Rui Wang, Karl Drlica, and Xilin Zhao. "Mutant Prevention Concentration-Based Pharmacokinetic/Pharmacodynamic Indices as Dosing Targets for Suppressing the Enrichment of Levofloxacin-Resistant Subpopulations of Staphylococcus aureus." Antimicrobial Agents and Chemotherapy 55, no. 5 (2011): 2409–12. http://dx.doi.org/10.1128/aac.00975-10.

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ABSTRACTMIC- and mutant prevention concentration (MPC)-based pharmacokinetic/pharmacodynamic (PK/PD) indices were compared for suitability as attainment targets for restricting amplification of levofloxacin-resistant mutant subpopulations. When threeStaphylococcus aureusstrains were examined with a hollow-fiber PK/PD model, area under the concentration-time curve over 24 h (AUC24)/MPC values of >25 and maximum concentration of drug in serum (Cmax)/MPC values of >2.2 predicted resistance outcome among different isolates with an interisolate kappa coefficient of 1. MIC-based mutant-restric

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Zhanel, George G., Vibhu Vishisht, Ed Tam, Daryl J. Hoban, and James A. Karlowsky. "Mutant Prevention Concentrations of Doripenem and Meropenem Alone and in Combination with Colistin (Polymyxin E), Levofloxacin and Tobramycin inPseudomonas aeruginosa." Canadian Journal of Infectious Diseases and Medical Microbiology 20, suppl a (2009): 67A—71A. http://dx.doi.org/10.1155/2009/801612.

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BACKGROUND: With a limited number of available antimicrobial agents to treatPseudomonas aeruginosainfections, the prevention of emergence of antimicrobial resistance and its subsequent spread is critical. In the present study, the mutant prevention concentration (MPC) of doripenem was examined and compared with meropenem for its ability to prevent resistant mutant selection forP aeruginosawhen used alone and in combination with the other antipseudomonal agents colistin (polymyxin E), levofloxacin and tobramycin. OBJECTIVE: To determine if two antimicrobial agents that possessed different mecha

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13

Shetgaonkar, Ajay, Aleksandra Lekić, José Luis Rueda Torres, and Peter Palensky. "Microsecond Enhanced Indirect Model Predictive Control for Dynamic Power Management in MMC Units." Energies 14, no. 11 (2021): 3318. http://dx.doi.org/10.3390/en14113318.

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The multi-modular converter (MMC) technology is becoming the preferred option for the increased deployment of variable renewable energy sources (RES) into electrical power systems. MMC is known for its reliability and modularity. The fast adjustment of the MMC’s active/reactive powers, within a few milliseconds, constitutes a major research challenge. The solution to this challenge will allow accelerated integration of RES, without creating undesirable stability issues in the future power system. This paper presents a variant of model predictive control (MPC) for the grid-connected MMC. MPC is

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Koç, Atakan, and Çağrı Arı. "Milk Yield, Reproduction and Milk Quality Characteristics of Simmental and Red-Holstein Cattle Raised at a Dairy Farm in Aydın Province: 2. Milk Quality." Turkish Journal of Agriculture - Food Science and Technology 8, no. 10 (2020): 2074–80. http://dx.doi.org/10.24925/turjaf.v8i10.2074-2080.3512.

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In this study, the milk quality characteristics of Simmental (SIM) and Red-Holstein (RH) breeds raised in a private farm in Aydın were determined. As milk quality properties, the percentages of protein (MPC), lactose (MLC), non-fat dry matter (NFDMC), total dry matter (TDMC), casein (MCC) contents and also milk urea nitrogen (MUN), oleic acid (OA), beta-hydroxybutyric acid (BHBA) and somatic cell count (SCC) were determined. The averages of MPC, MLC, NFDMC, TDMC, MCC, MUN, OA, BHBA and Log10SCC belonging to RH and SIM breeds are 3.38 ± 0.021% and 3.40 ± 0.015%, 4.86 ± 0.028% and 4.81 ± 0.019%,

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Gelasakis, Athanasios I., Apostolos Angelidis, Rebecca Giannakou, and Georgios Arsenos. "Bacterial subclinical mastitis and its effect on milk quality traits in low-input dairy goat herds." Veterinary Record 183, no. 14 (2018): 449. http://dx.doi.org/10.1136/vr.104804.

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The objective of the study was to investigate and quantify the effects of subclinical mastitis (SCM) on the gross chemical composition of milk in low-input dairy goat herds. Dairy goats (n=590) of two native Greek breeds from four representative low-input farms were randomly selected and used in the study. Α prospective study was conducted, including monthly monitoring and milk sampling of the same individual goats during the course of two consecutive milking periods. Mixed linear regression models were built to assess how the chemical composition of milk was affected by (1) SCM and (2) the di

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Blondeau, Joseph M., and Shantelle D. Fitch. "Comparison of the Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and 7 Other Antimicrobial Agents Tested Against Swine Isolates of Actinobacillus pleuropneumoniae and Pasteurella multocida." Molecules 29, no. 22 (2024): 5448. http://dx.doi.org/10.3390/molecules29225448.

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Pradofloxacin is a dual targeting, bactericidal fluoroquinolone recently approved for treating bacteria causing swine respiratory disease. Currently, an abundance of in vitro data does not exist for pradofloxacin. We determined the minimum inhibitory concentration (MIC) and mutant prevention concentrations (MPC) of pradofloxacin compared to ceftiofur, enrofloxacin, florfenicol, marbofloxacin, tildipirosin, tilmicosin and tulathromycin against swine isolates of Actinobacillus pleuropneumoniae and Pasteurella multocida. Overall, pradofloxacin had the lowest MIC and MPC values as compared to the

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Lastovetsky, Alexey L. "mpC." ACM SIGPLAN Notices 31, no. 2 (1996): 13–20. http://dx.doi.org/10.1145/226060.226064.

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Weycker, Derek, Xiaoyan Li, Alex Kartashov, et al. "Risk and Consequences of Neutropenic Complications Among Patients with Metastatic Solid Tumors Receiving Myelosuppressive Chemotherapy." Blood 122, no. 21 (2013): 2962. http://dx.doi.org/10.1182/blood.v122.21.2962.2962.

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Abstract Background While several studies have evaluated the risk and consequences of febrile neutropenia (FN) among patients receiving cancer chemotherapy in US clinical practice, none have focused on a broad group of patients with metastatic disease. Methods A retrospective cohort design and US healthcare claims data (2007-2011) were utilized. Study population included adult patients who underwent myelosuppressive chemotherapy for metastatic cancer of the breast (MBC), colon/rectum (MCC), lung (MLC), ovaries (MOC), or prostate (MPC). For each subject, the first qualifying chemotherapy course

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Golikova, Maria V., Elena N. Strukova, Kamilla N. Alieva, et al. "Meropenem MICs at Standard and High Inocula and Mutant Prevention Concentration Inter-Relations: Comparative Study with Non-Carbapenemase-Producing and OXA-48-, KPC- and NDM-Producing Klebsiella pneumoniae." Antibiotics 12, no. 5 (2023): 872. http://dx.doi.org/10.3390/antibiotics12050872.

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The minimal inhibitory concentration (MIC) is conventionally used to define in vitro levels of susceptibility or resistance of a specific bacterial strain to an antibiotic and to predict its clinical efficacy. Along with MIC, other measures of bacteria resistance exist: the MIC determined at high bacterial inocula (MICHI) that allow the estimation of the occurrence of inoculum effect (IE) and the mutant prevention concentration, MPC. Together, MIC, MICHI and MPC represent the bacterial “resistance profile”. In this paper, we provide a comprehensive analysis of such profiles of K. pneumoniae st

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Bakeer, Abualkasim, Mohammed Alhasheem, and Saeed Peyghami. "Efficient Fixed-Switching Modulated Finite Control Set-Model Predictive Control Based on Artificial Neural Networks." Applied Sciences 12, no. 6 (2022): 3134. http://dx.doi.org/10.3390/app12063134.

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The disadvantage of finite control set-model predictive control (FCS-MPC) is that the switching frequency is variable and relies on the sampling time and operating point. This paper describes how to implement a new algorithm to achieve a fixed-switching frequency functionality for the FCS-MPC. The used approach combines the FCS-MPC with the SVPWM, resulting in the calculation of dwell times and the selection of the best two active vectors for the next sample interval. These dwell times have a significant impact on FCS-MPC performance during transient and steady-state conditions, and their valu

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Homma, Tomoyuki, Toshihiko Hori, Giichi Sugimori, and Yoshinori Yamano. "Pharmacodynamic Assessment Based on Mutant Prevention Concentrations of Fluoroquinolones To Prevent the Emergence of Resistant Mutants of Streptococcus pneumoniae." Antimicrobial Agents and Chemotherapy 51, no. 11 (2007): 3810–15. http://dx.doi.org/10.1128/aac.01372-06.

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ABSTRACT The objective of this study was to investigate the relationship between pharmacokinetic and pharmacodynamic parameters, on the basis of the mutant prevention concentration (MPC) concept, and the emergence of resistant mutants of Streptococcus pneumoniae to fluoroquinolone antibacterials. Some clinical isolates with various MIC and MPC values of moxifloxacin and levofloxacin were exposed under conditions simulating the time-concentration curves observed when moxifloxacin (400 or 80 mg, once a day) or levofloxacin (200 mg, twice a day) was orally administered by using an in vitro pharma

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Dahdouh, E., S. H. Shoucair, S. E. Salem, and Z. Daoud. "Mutant Prevention Concentrations of Imipenem and Meropenem againstPseudomonas aeruginosaandAcinetobacter baumannii." Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/979648.

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The aim of this study was to determine the usefulness of the MPC of carbapenems against clinical isolates ofPseudomonasspp.andAcinetobacterspp. and to assess its possible relationship with mechanisms of resistance. Detection of the mechanisms of resistance was performed using Antibiotic Susceptibility Testing, Double Disk Synergy, disk antagonism, addition of NaCl to the medium, addition of PBA or EDTA to Carbapenem disks, addition of PBA to Cefoxitin disks, and CCCP test for 10Pseudomonasspp. andAcinetobacter baumanniistrains. The MIC and MPC were determined using the broth macrodilution and

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Soomro, Jahangeer Badar, Faheem Akhtar Chachar, Madad Ali Shah, Abdul Aziz Memon, Faisal Alsaif, and Sager Alsulamy. "Optimized Circulating Current Control and Enhanced AC Fault Ride-through Capability Using Model Predictive Control for MMC-HVDC Applications." Energies 16, no. 13 (2023): 5159. http://dx.doi.org/10.3390/en16135159.

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This paper presents a novel model predictive control (MPC) approach for suppressing circulating currents in MMC-based HVDC systems. The proposed MPC eliminates the need for PI-regulators and pulse width modulators, resulting in improved dynamic response and controllability. The methodology demonstrates exceptional efficacy in controlling output current and addressing voltage ripple concerns associated with sub module (SM) capacitors. An innovative, communication-free fault ride-through (FRT) method is also introduced, eliminating the need for a DC chopper and ensuring rapid recovery following

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Reid, Suzanna, Alec Ritchie, Landin Boring, et al. "Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2." Blood 93, no. 5 (1999): 1524–33. http://dx.doi.org/10.1182/blood.v93.5.1524.

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Abstract Chemokines regulate hematopoiesis in part by influencing the proliferative status of myeloid progenitor cells (MPC). Human MCP-1/murine JE, a myelosuppressive chemokine, specifically binds C-C chemokine receptor 2 (CCR2). Transgenic mice containing a targeted disruption in CCR2 that prevents expression of CCR2 mRNA and protein and have MPC that are insensitive to inhibition by MCP-1 and JE in vitro were assessed for potential abnormalities in growth of bone marrow (BM) and spleen MPC. MPC in both unseparated and c-kit+lin− populations of BM from CCR2-deficient (−/−) mice were in a gre

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Reid, Suzanna, Alec Ritchie, Landin Boring, et al. "Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2." Blood 93, no. 5 (1999): 1524–33. http://dx.doi.org/10.1182/blood.v93.5.1524.405k07_1524_1533.

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Chemokines regulate hematopoiesis in part by influencing the proliferative status of myeloid progenitor cells (MPC). Human MCP-1/murine JE, a myelosuppressive chemokine, specifically binds C-C chemokine receptor 2 (CCR2). Transgenic mice containing a targeted disruption in CCR2 that prevents expression of CCR2 mRNA and protein and have MPC that are insensitive to inhibition by MCP-1 and JE in vitro were assessed for potential abnormalities in growth of bone marrow (BM) and spleen MPC. MPC in both unseparated and c-kit+lin− populations of BM from CCR2-deficient (−/−) mice were in a greatly incr

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Alotaibi, Abdullah, Jerrold Petrofsky, Noha S. Daher, Everett Lohman, Hasan M. Syed, and Haneul Lee. "The Effect of Monophasic Pulsed Current with Stretching Exercise on the Heel Pain and Plantar Fascia Thickness in Plantar Fasciitis: A Randomized Controlled Trial." Healthcare 8, no. 2 (2020): 79. http://dx.doi.org/10.3390/healthcare8020079.

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Plantar fasciitis (PF) is one of the most common causes of heel and foot pain. Monophasic pulsed current (MPC) is an electrical stimulation used to accelerate the healing processes. The purpose of this study was to determine the effect of MPC and MPC combined with plantar fascia stretching exercises (SE) on heel pain and plantar fascia thickness in treatment of PF and see if there is any relationship between heel pain and plantar fascia thickness after intervention. Forty-four participants diagnosed with PF were randomly assigned to two group; MPC group or MPC combined with plantar fascia SE.

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Hermsen, Elizabeth D., Laurie B. Hovde, George N. Konstantinides, and John C. Rotschafer. "Mutant Prevention Concentrations of ABT-492, Levofloxacin, Moxifloxacin, and Gatifloxacin against Three Common Respiratory Pathogens." Antimicrobial Agents and Chemotherapy 49, no. 4 (2005): 1633–35. http://dx.doi.org/10.1128/aac.49.4.1633-1635.2005.

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ABSTRACT The purpose of this study was to compare the mutant prevention concentration (MPC) of ABT-492 to those of levofloxacin, moxifloxacin, and gatifloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The fluoroquinolones had comparable mutation selection windows, which is the ratio of MPC/MIC, for all isolates.

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Uzun, Nazif. "A Study on Milk Quality Characteristics of Simmental (Fleckvieh) Cows Reared Karacabey District of Bursa Province." Hayvansal Üretim 66, no. 1 (2025): 15–24. https://doi.org/10.29185/hayuretim.1581306.

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Objective The aim of this study was to determine the milk quality characteristics of Simmental (SIM) (Fleckvieh) cattle originating from Austria and Germany Material and Methods: For this aim, a total of 1928 milk samples taken during morning milking in different seasons between 2018 and 2022 from cattle raised in a disease-free private dairy farm in Karacabey District of Bursa Province were evaluated. Results: Milk quality characteristics include fat (MFC), protein (MPC), lactose (MLC), total dry matter content (TDMC), milk urea nitrogen (MUN) amount and Log10SCC were determined. Parity effec

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Chen, Yongxin, Jonathan Gelfond, Linda M. McManus, and Paula K. Shireman. "Temporal microRNA expression during in vitro myogenic progenitor cell proliferation and differentiation: regulation of proliferation by miR-682." Physiological Genomics 43, no. 10 (2011): 621–30. http://dx.doi.org/10.1152/physiolgenomics.00136.2010.

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MicroRNAs (miRNAs) regulate gene expression by repressing target genes at the posttranscriptional level. Since miRNAs have unique expression profiles in different tissues, they provide pivotal regulation of many biological processes. The present study defined miRNA expression during murine myogenic progenitor cell (MPC) proliferation and differentiation to identify miRNAs involved in muscle regeneration. Muscle-related gene expression analyses revealed that the time course and expression of myosin heavy chain (MHC) and transcription factors (Myf5, MyoD, myogenin, and Pax7) were similar during

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Wahid, Abdul, and Naufal Syafiq Maro. "Multi Input Multi Output (MIMO) Control 2x2 at Vacuum Distillation Unit for LVGO, MVGO, and HVGO Production." E3S Web of Conferences 67 (2018): 03012. http://dx.doi.org/10.1051/e3sconf/20186703012.

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Currently, Indonesia is still experiencing a fuel deficit, so it is necessary to build a new oil refinery and a process optimization at an existing refinery. A vacuum distillation unit (VDU) is used to process the atmospheric residue products from crude distillation unit (CDU). A multivariable model predictive control (MMPC) is proposed to improve a control performance in VDU because of the interaction between variables in the unit. Therefore, it is necessary to find the variables that interact with each other. In this study only two variables are discussed. Set point (SP) and disturbance chan

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GUAN, JIAN-GUO, JUN HUANG, SU-LING ZHAO, and RUN-ZHANG YUAN. "CHARACTERIZATION AND PROPERTIES OF METAL PHTHALOCYANINE-Fe3O4 NANOCOMPOSITES FOR ELECTROMAGNETORHEOLOGICAL FLUIDS." International Journal of Modern Physics B 15, no. 06n07 (2001): 599–609. http://dx.doi.org/10.1142/s0217979201005052.

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Meso-scale metal phthalocyanine (MPc, M=Cu, Ni, Mn, or Co)- Fe 3 O 4 nanocomposites for EMR fluids have been prepared and well characterized. The results indicate that there exists chemical bonding between MPc and Fe 3 O 4 nanoparticles, and their strength of chemical bonding increases in the following order: NiPc < CuPc < CoPc ~ MnPc . Compared to Fe 3 O 4 nanoparticles, MPc- Fe 3 O 4 nanocomposites have superior ability to anti-oxidation and thermal stability, and show almost the same saturation magnetic strength, but much less coercive force. All MPc- Fe 3 O 4 nanocomposites have irre

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Zhang, Jiayuan, Mengyuan Wu, Shuo Diao та ін. "Pharmacokinetic/Pharmacodynamic Evaluation of Aztreonam/Amoxicillin/Clavulanate Combination against New Delhi Metallo-β-Lactamase and Serine-β-Lactamase Co-Producing Escherichia coli and Klebsiella pneumoniae". Pharmaceutics 15, № 1 (2023): 251. http://dx.doi.org/10.3390/pharmaceutics15010251.

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This study aimed to examine specific niches and usage for the aztreonam/amoxicillin/clavulanate combination and to use population pharmacokinetic simulations of clinical dosing regimens to predict the impact of this combination on restricting mutant selection. The in vitro susceptibility of 19 New-Delhi metallo-β-lactamase (NDM)-producing clinical isolates to amoxicillin/clavulanate and aztreonam alone and in co-administration was determined based on the minimum inhibitory concentration (MIC) and mutant prevention concentration (MPC). The fractions of a 24-h duration that the free drug concent

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Botrus, Gehan, Denise Roe, Gayle S. Jameson, et al. "Mitomycin C in Homologous Recombination Deficient Metastatic Pancreatic Cancer after Disease Progression on Platinum-Based Chemotherapy and Olaparib." Biomedicines 10, no. 11 (2022): 2705. http://dx.doi.org/10.3390/biomedicines10112705.

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Recent efforts to personalize treatment with platinum-based chemotherapy and PARP inhibitors have produced promising results in homologous recombinant deficient (HRD) metastatic pancreatic cancer (MPC). However, new strategies are necessary to overcome resistance. The below case series documents patients treated at the HonorHealth Research Institute with a diagnosis of HRD MPC who received Mitomycin C (MMC) treatment from January 2013 until July 2018. Five HRD MPC patients treated with MMC were evaluated. All patients received at least one course of treatment. Mean age at MMC treatment initiat

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Sluis, Geerte L. Van, Paris Margaritis, Michael Sliozberg, et al. "Zymogen Protein C as a Novel Modulator of Cancer Progression In Murine Models." Blood 116, no. 21 (2010): 718. http://dx.doi.org/10.1182/blood.v116.21.718.718.

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Abstract Abstract 718 Recent evidence on the role of the protein C (PC) pathway in tumor progression of the experimental mouse melanoma model has revealed that inhibition of the cytoprotective effects of endogenous activated PC (aPC) enhances tumor cell extravasation, whereas exogenous administration of recombinant human APC has a protective effect. Moreover transgenic mice overexpressing endothelial PC receptor (EPCR) in tissue endothelium exhibit low rates of tumor metastasis. Here we report our findings in C57Bl/6 mice expressing murine forms of APC or zymogen PC by viral-mediated gene tran

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Kesteman, Anne-Sylvie, Aude A. Ferran, Agnès Perrin-Guyomard, et al. "Influence of Inoculum Size and Marbofloxacin Plasma Exposure on the Amplification of Resistant Subpopulations of Klebsiella pneumoniae in a Rat Lung Infection Model." Antimicrobial Agents and Chemotherapy 53, no. 11 (2009): 4740–48. http://dx.doi.org/10.1128/aac.00608-09.

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ABSTRACT We tested the hypothesis that the bacterial load at the infection site could impact considerably on the pharmacokinetic/pharmacodynamic (PK/PD) parameters of fluoroquinolones. Using a rat lung infection model, we measured the influence of different marbofloxacin dosage regimens on selection of resistant bacteria after infection with a low (105 CFU) or a high (109 CFU) inoculum of Klebsiella pneumoniae. For daily fractionated doses of marbofloxacin, prevention of resistance occurred for an area-under-the-concentration-time-curve (AUC)/MIC ratio of 189 h for the low inoculum, whereas fo

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Sindelar, Georg, Xilin Zhao, Anthony Liew, et al. "Mutant Prevention Concentration as a Measure of Fluoroquinolone Potency against Mycobacteria." Antimicrobial Agents and Chemotherapy 44, no. 12 (2000): 3337–43. http://dx.doi.org/10.1128/aac.44.12.3337-3343.2000.

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ABSTRACT Mutant prevention concentration (MPC) has been proposed as a new measure of antibiotic potency by which the ability to restrict selection of resistant mutants is evaluated. To determine whether MPC provides potency information unavailable from the more customary measurement of the MIC, 18 fluoroquinolones were examined for their ability to block the growth of Mycobacterium smegmatis and to select resistant mutants from wild-type populations. Both MPC and MIC were affected by changes in the moiety at the fluoroquinolone C-8 position and in alkyl groups attached to the C-7 piperazinyl r

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Prous, J., and J. Castañer. "MPC-1304." Drugs of the Future 16, no. 1 (1991): 25. http://dx.doi.org/10.1358/dof.1991.016.01.129877.

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McIntyre, J. A., J. Castañer, and D. Fernández-Forner. "MPC-7869." Drugs of the Future 31, no. 1 (2006): 22. http://dx.doi.org/10.1358/dof.2006.031.01.961798.

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Weihua, Zhao, and Tiauw Hiong Go. "Robust Decentralized Formation Flight Control." International Journal of Aerospace Engineering 2011 (2011): 1–13. http://dx.doi.org/10.1155/2011/157590.

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Motivated by the idea of multiplexed model predictive control (MMPC), this paper introduces a new framework for unmanned aerial vehicles (UAVs) formation flight and coordination. Formulated using MMPC approach, the whole centralized formation flight system is considered as a linear periodic system with control inputs of each UAV subsystem as its periodic inputs. Divided into decentralized subsystems, the whole formation flight system is guaranteed stable if proper terminal cost and terminal constraints are added to each decentralized MPC formulation of the UAV subsystem. The decentralized robu

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Zhao, Xilin, William Eisner, Nathan Perl-Rosenthal, Barry Kreiswirth, and Karl Drlica. "Mutant Prevention Concentration of Garenoxacin (BMS-284756) for Ciprofloxacin-Susceptible or -Resistant Staphylococcus aureus." Antimicrobial Agents and Chemotherapy 47, no. 3 (2003): 1023–27. http://dx.doi.org/10.1128/aac.47.3.1023-1027.2003.

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ABSTRACT The new quinolone garenoxacin (BMS-284756), which lacks a C-6 fluorine, was examined for its ability to block the growth of Staphylococcus aureus. Measurement of the MIC and the mutant prevention concentration (MPC) revealed that garenoxacin was 20-fold more potent than ciprofloxacin for a variety of ciprofloxacin-susceptible isolates, some of which were resistant to methicillin. The MPC for 90% of the isolates (MPC90) was below published serum drug concentrations achieved with recommended doses of garenoxacin. These in vitro observations suggest that garenoxacin has a low propensity

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Petrovskaya, Tatyana A., and Dmitry V. Tapalskiy. "Influence of different antibiotic groups on the development of mutational resistance to colistin among Klebsiella pneumoniae." Clinical Microbiology and Antimicrobial Chemotherapy 23, no. 2 (2021): 166–72. http://dx.doi.org/10.36488/cmac.2021.2.166-172.

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Objective. To determine the concentration of colistin, preventing the selection of colistin-resistant mutants of K. pneumoniae, and to evaluate the effect of antibiotics of different groups on the development of mutational resistance to colistin. Materials and Methods. Minimum inhibitory concentrations (MIC) of colistin were determined for 88 K. pneumoniae strains by the method of serial microdilutions in broth, and carbapenemase genes were detected. The selection of colistin-resistant subpopulations was performed on cation-adjusted MüllerHinton agar (MHA) with the addition of 16 mg/l colistin

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Nauman, Muhammad, and Wajiha Shireen. "Improved Model-Free Predictive Control of a Three-Phase Inverter." Energies 17, no. 15 (2024): 3761. http://dx.doi.org/10.3390/en17153761.

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Model predictive control (MPC) performance depends on the accuracy of the system model. Moreover, the optimization algorithm of MPC requires numerous online computations. These inherent limitations of MPC hinder its application in power electronics systems. This paper proposes a two-part solution for these challenges for a three-phase inverter with an output LC filter. The first part of the control scheme is a linear and modified model-free approach based on the auto-regressive structure (ARX) with exogenous input. The second part is the computationally efficient optimization algorithm based o

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Saltarelli, Francesca, Alessandro Moscetti, Guglielmo Bruno, et al. "Heart Function In Systemic and Localized AL Amyloidosis: Role of NT-ProBNP and MPC-1." Blood 116, no. 21 (2010): 5006. http://dx.doi.org/10.1182/blood.v116.21.5006.5006.

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Abstract Abstract 5006 In AL amyloidosis typical sites of amyloid buildup are heart, skin, gastrointestinal tract, liver, kidneys, and blood vessels. To evaluate the heart involvement in systemic and localized amyloidosis proBNP, peptide (NT-proBNP; 76 amino acids) and MPC-1 were investigated. NT-proBNP have been described as useful marker for the diagnosis heart disease, and its plasma concentrations correlate with the functional classification of patients according to the New York Heart Association (NYHA). MCP-1 is a chemokine that activates mononuclear phagocytes by promoting leukocyte–endo

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Chang, Kuo-Wei, Chia-En Lin, Hsi-Feng Tu, Hsin-Yao Chung, Yi-Fen Chen, and Shu-Chun Lin. "Establishment of a p53 Null Murine Oral Carcinoma Cell Line and the Identification of Genetic Alterations Associated with This Carcinoma." International Journal of Molecular Sciences 21, no. 24 (2020): 9354. http://dx.doi.org/10.3390/ijms21249354.

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Head and neck squamous cell carcinoma (HNSCC), including oral squamous cell carcinoma (OSCC), ranks sixth in cancer incidence worldwide. To generate OSCC cells lines from human or murine tumors, greatly facilitates investigations into OSCC. This study describes the establishing of a mouse palatal carcinoma cell line (designated MPC-1) from a spontaneous tumor present in a heterozygous p53 gene loss C57BL/6 mouse. A MPC-1-GFP cell subclone was then generated by lentivirus infection resulting in stable expression of green fluorescent protein. Assays indicated that MPC-1 was a p53 null polygonal

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Uckun, F., S. Morar, J. Larson, and S. Qazi. "Survival outcome of metastatic adenocarcinoma patients after patient-tailored outpatient chemotherapy guided by fusion imaging." Journal of Clinical Oncology 24, no. 18_suppl (2006): 13145. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.13145.

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13145 Background: We treated 173 patients with metastatic Stage IV adenocarcinoma, including 65 patients with metastatic colorectal cancer (MCRC), 22 patients with metastatic pancreas cancer (MPC), and 86 patients with metastatic breast cancer (MBC) in an outpatient setting. The metastatic sites included liver (49% of patients), bone (39%), lung (36%), brain (16%), peritoneum (16%), lymph node (14%) and chest wall (8%). Methods: MCRC patients received multiple cycles of Xeloda-based empirical chemotherapy regimens: alone or in combination with Irinotecan, Oxaliplatin or Mitomycin. MPC patients

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Hamedelniel Suliman, Munzir, Mohammad Nahid Siddiqui, and Chanbasha Basheer. "Surface Functionalization of Mesoporous Carbon for the Enhanced Removal of Strontium and Cesium Radionuclides." Coatings 10, no. 10 (2020): 923. http://dx.doi.org/10.3390/coatings10100923.

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Mesoporous carbons (MPC) and modified mesoporous carbons (MMPC) were prepared from asphalt for the adsorption of several metal ions from the aqueous solution. In this study, we investigated the adsorption efficiency of Cesium (Cs+) and Strontium (Sr2+) ions using mesoporous and modified mesoporous carbons. The optimum conditions for the removal of Cs+ and Sr2+ were at 10.0 pH, 1.00 ppm (1000.0 µg/L) concentration, 20.0 min contact time, 0.20 g/L adsorbent dose, 25.0 °C temperature with more than 95.0% removal of Cs+ and Sr2+ ions using MMPC. The limit of detection (LOD) was found to be 0.030 p

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Li, Yichen, Dongwei Xiao, Zhibo Liu, Qi Pang, and Shuai Wang. "Metamorphic Testing of Secure Multi-party Computation (MPC) Compilers." Proceedings of the ACM on Software Engineering 1, FSE (2024): 1216–37. http://dx.doi.org/10.1145/3643781.

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The demanding need to perform privacy-preserving computations among multiple data owners has led to the prosperous development of secure multi-party computation (MPC) protocols. MPC offers protocols for parties to jointly compute a function over their inputs while keeping those inputs private. To date, MPC has been widely adopted in various real-world, privacy-sensitive sectors, such as healthcare and finance. Moreover, to ease the adoption of MPC, industrial and academic MPC compilers have been developed to automatically translate programs describing arbitrary MPC procedures into low-level MP

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Разиньков, Egor Razinkov, Воропаев, O. Voropaev, Киев, and N. Kiev. "THE DEFINITION OF THE LIMIT OF SATURATION WITH WOOD PLATES FOR DOMESTIC PREMISES." Forestry Engineering Journal 7, no. 1 (2017): 162–67. http://dx.doi.org/10.12737/25207.

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One of the topical issues of the application of furniture in domestic premises is defining its limiting (maximum) saturation in the premises so that the air in these premises, the allocation of harmful substances does not exceed the maximum allowable level (maximum permissible concentrations - MPC). It is known that in using furniture of wood-based panels (particle Board, Chipboard, wood fiber, MDF) this substance is formaldehyde. Currently, the MoH established the formaldehyde MPC in the air at the level of 0.01 mg/m3. The aim of this work was to determine the limit of saturation with the woo

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Alharbi, Yousef, Ahmed Darwish, and Xiandong Ma. "A Review of Model Predictive Control for Grid-Connected PV Applications." Electronics 14, no. 4 (2025): 667. https://doi.org/10.3390/electronics14040667.

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This paper presents the latest advancements in model predictive control (MPC) for grid-connected power inverters in renewable energy applications. It focuses on grid-connected PV systems employing MPC techniques. Two main categories of MPC are introduced: continuous control MPC (CC MPC) and predetermined control MPC (PC MPC). In CC MPC, a modulator is required to generate the control signal, whereas in PC MPC, the MPC controller directly performs the control process and generates the control pulses. Consequently, PC MPC is preferred for most power converter applications due to its lower comput

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Chi, Hengxuan, and Karl R. Englund. "Interfacial properties of magnesium phosphate ceramics and sugar maple (Acer saccharum)." Holzforschung 68, no. 5 (2014): 575–82. http://dx.doi.org/10.1515/hf-2013-0113.

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Abstract The interfacial shear strength (τi) between magnesium phosphate ceramics (MPC) and sugar maple (Acer saccharum) has been evaluated by means of a pullout test method. The binder system monopotassium phosphate (MKP) and magnesium oxide (MgO) resulted in the highest τi at a MKP/MgO ratio of 3:1. The influence of the levels of MPC binder and aggregates on the interfacial properties has been observed based on a mixture design model. The aggregates were Portland cement (PC), wollastonite (WO), and vitrified calcium aluminosilicates (VCAS). The MPC binder level was the primary factor influen

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