Journal articles on the topic 'Mosquitoes Control Philippines'

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1

Cattarino, Lorenzo, Isabel Rodriguez-Barraquer, Natsuko Imai, Derek A. T. Cummings, and Neil M. Ferguson. "Mapping global variation in dengue transmission intensity." Science Translational Medicine 12, no. 528 (January 29, 2020): eaax4144. http://dx.doi.org/10.1126/scitranslmed.aax4144.

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Intervention planning for dengue requires reliable estimates of dengue transmission intensity. However, current maps of dengue risk provide estimates of disease burden or the boundaries of endemicity rather than transmission intensity. We therefore developed a global high-resolution map of dengue transmission intensity by fitting environmentally driven geospatial models to geolocated force of infection estimates derived from cross-sectional serological surveys and routine case surveillance data. We assessed the impact of interventions on dengue transmission and disease using Wolbachia-infected mosquitoes and the Sanofi-Pasteur vaccine as specific examples. We predicted high transmission intensity in all continents straddling the tropics, with hot spots in South America (Colombia, Venezuela, and Brazil), Africa (western and central African countries), and Southeast Asia (Thailand, Indonesia, and the Philippines). We estimated that 105 [95% confidence interval (CI), 95 to 114] million dengue infections occur each year with 51 (95% CI, 32 to 66) million febrile disease cases. Our analysis suggests that transmission-blocking interventions such as Wolbachia, even at intermediate efficacy (50% transmission reduction), might reduce global annual disease incidence by up to 90%. The Sanofi-Pasteur vaccine, targeting only seropositive recipients, might reduce global annual disease incidence by 20 to 30%, with the greatest impact in high-transmission settings. The transmission intensity map presented here, and made available for download, may help further assessment of the impact of dengue control interventions and prioritization of global public health efforts.
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2

Rahman, Shah Md Mahfuzar, Shah Monir Hossain, and Mahmood Uz Jahan. "Dengue prevention and control: Bangladesh context." Bangladesh Medical Research Council Bulletin 45, no. 2 (August 7, 2019): 66–67. http://dx.doi.org/10.3329/bmrcb.v45i2.42533.

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Dengue is the most common mosquito-borne, viral disease in the world. Dengue virus is a single stranded positive polarity RNA virus, belongs to the family Flaviviridae. It is transmitted through the bite of an infected female mosquito of Aedes species - mainly the species Aedes aegypti and, to a lesser extent, Aedes albopictus. This mosquito also transmits Chikungunya, Zika and Yellow fever viruses.1-4 There are 4 distinct, but closely related, serotypes of the virus (DEN-1, DEN-2, DEN-3 and DEN-4). Recovery from infection by one serotype provides heterotypic or cross-immunity to the other serotypes. This is only partial and temporary, lasts only a few months, but homotype immunity is lifelong. For this reason, a person can be infected with a dengue virus as many as four times in his or her lifetime. Subsequent infections (secondary infection) by other serotypes increase the risk of developing severe dengue.1-5 The fifth variant DENV-5 has been isolated in October 2013. DENV-5 has been detected during screening of viral samples taken from a 37 year old farmer admitted in a hospital in Sarawak state of Malaysia in the year 2007.6 The first record of a case of probable dengue fever reported in a Chinese medical encyclopedia from the Jin Dynasty (265–420AD).The first recognized dengue epidemics occurred almost simultaneously in Asia, Africa, and North America in the 1780s, shortly after the identification and naming of the disease in 1779. The first confirmed case report dates from 1789 and is by Benjamin Rush, who coined the term "breakbone fever" because of the symptoms of myalgia and arthralgia.7 Haemorrhagic dengue was first recognised in the 1950s during dengue epidemics in the Philippines and Thailand. 8 The incidence of dengue has grown dramatically around the world in recent decades. A vast majority of the cases are asymptomatic and hence the actual numbers of dengue cases are underreported and many cases are misclassified. Dengue is common in more than 100 countries around the globe, with its endemicity in Asia, the Pacific, Africa and the Latin American countries. Forty percent of the world’s population, about 3 billion people live in the areas with a risk of dengue. Annually, some 400 million people get infected with dengue, with an occurrence of 100 million clinically apparent infections, and 22,000 die from severe dengue across the globe. The increasing incidence, severity and frequency of dengue epidemics are linked to trends in human ecology, demography and globalisation, and may have been influenced by climate change. 8,9 In Bangladesh, dengue occurred sporadically since 1964.10 Literature shows, the first documented case of dengue like fever occurred in 1964, popularly known as "Dacca fever" which later on serologically proved as dengue fever.11 Bangladesh has been experiencing episodes of dengue fever in every year since 2000. All four serotypes have been detected, with DENV-3 predominance until 2002.12,13 After that, no DENV-3 or DENV-4 was reported from Bangladesh. During 2013-2016, DEN2 was predominant followed by DEN-1 in circulation. Institute of Epidemiology, Disease Control & Research (IEDCR) predicted that as the serotypes DENV-3 and DENV-4 are in circulation in the neighbouring countries, they may create epidemics of secondary dengue in the near future in Bangladesh.14 In 2017, reemergence of DENV-3 was identified; subsequently there was a sharp rise in dengue cases from the beginning of the monsoon season in 2018.15 In 2000, dengue attacked 5,551 individuals and the number of deaths was 93. Since 2003, the death rate has declined gradually, with zero fatalities in subsequent couple of years, but a devastating turn with 10,148 cases and 26 deaths in 2018. In 2019, during January to July, number total cases were 18,484, with 57 deaths.16 Directorate General of Health Services conducts periodical (Pre-monsoon, Monsoon and Post- monsoon) Aedes survey to estimate the vector density of the mosquito. The monsoon survey (18-27 July 2019) of 100 sites of 98 wards in Dhaka city both North and South revealed that the number of adult aedes mosquito was increased by 13.52 folds, in compare to the pre-monsoon (3-12 March 2019) survey.17 The aedes larvae were also increased by 12.5 folds in this period. Breteau Index (BI) was considered in the study. Report shows that the BI was more than 20 in 57% and 64% of total wards in Dhaka North and Dhaka South respectively. Furthermore, in terms of House Index (HI) or percentage of houses infested, 75% and 83% of total wards in North and South city respectively having HI more than 5.17 Furthermore, recent studies show that mosquitoes have grown resistant, and how certain insecticides are completely ineffective against them.18 Considering the situation, the Ministry of Health and Family Welfare, has taken commendable steps including training on case management for nurses and doctors across the country, review of the national guidelines on case management, expansion of dengue services along with increasing bed capacities in hospitals, strengthened mass awareness with special attention to the school children and the community people, ensuring availability of dengue diagnostic kits, diagnostic services at free of cost in public health facilities and fixed and reduced rate in private sectors, strengthening collaboration with city corporations, municipalities and other agencies both in public and private sectors and development partners. Prevention and control of dengue in Bangladesh, is not a sole responsibility for any single ministry and or its agencies. It needs effective and timely coordination, collaboration and partnership, among all the concerned ministries and their agencies, led by the Ministry of Health and Family Welfare. Furthermore, strengthening of the existing efforts including capacity building and resource mobilisation, and integrated surveillance, sustainable vector control, optimum and active community participation, and adequate monitoring and periodic evaluation throughout the year across the country, considering it an endemic disease, are strongly recommended. Bangladesh Med Res Counc Bull 2019; 45: 66-68
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3

Gardner, Lauren M., and Sahotra Sarkar. "Risk of Dengue Spread from the Philippines through International Air Travel." Transportation Research Record: Journal of the Transportation Research Board 2501, no. 1 (January 2015): 25–30. http://dx.doi.org/10.3141/2501-04.

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Epidemics of dengue fever occur every 3 to 4 years in the Philippines. The risk of a dengue fever outbreak in the Philippines has been heightened since Typhoon Haiyan struck the region in November 2013 because recovery efforts have been slow to progress. The structural damage caused by the typhoon resulted in an abundance of standing water, which can serve as mosquito breeding grounds. Should an outbreak of dengue occur, infected travelers departing the Philippines pose a risk because they may introduce the dengue virus into local vector populations (of Aedes aegypti and Aedes albopictus) at their destinations. This study quantifies the risk posed by potentially infected travelers departing the Philippines by using a network model that incorporates predictive species distribution models, demographic features of destination areas, and air traffic volumes. The analysis reveals that a majority of travelers departing Philippine airports deplane in regions suitable for harboring Aedes aegypti or Aedes albopictus; this factor increases the likelihood of further spread of the disease if an outbreak were to occur. Because it is impractical to implement all possible monitoring and control measures at all locations connected to the Philippines, this analysis ranks the set of candidates and thus allows surveillance resources to be optimally deployed.
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4

Herbuela, Von Ralph Dane M., Ferdinand S. de Guzman, Girly D. Sobrepeña, Andrew Benedict F. Claudio, Angelica Cecilia V. Tomas, Carmina M. Arriola-delos Reyes, Rachele A. Regalado, Mariama M. Teodoro, and Kozo Watanabe. "Knowledge, Attitude, and Practices Regarding Dengue Fever among Pediatric and Adult In-Patients in Metro Manila, Philippines." International Journal of Environmental Research and Public Health 16, no. 23 (November 26, 2019): 4705. http://dx.doi.org/10.3390/ijerph16234705.

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Background: Knowledge, attitude, and practice (KAP) of in-patients with dengue fever (DF) through hospital-based surveillance has not been done. This study aimed to assess and compare the KAP, identify its predictors, correlation, and protective factors among pediatric and adult patients with DF and community-based controls to structure proactive community-wide DF prevention and control programs. Methods: This case-control study involved clinically or serologically confirmed patients (pediatrics n = 233; adults n = 17) with DF admitted in three public hospitals and community-based controls in Metro Manila, Philippines. A pretested structured KAP questionnaire was administered to participants to assess their KAP. Results: Pediatric and adult patients had significantly lower mean scores in the practice (p < 0.001) domain compared with the pediatric and adult controls. Being in senior high school, having had days in hospital, and rash were predictors of KAP among pediatric patients. Knowledge and attitude of patients with DF did not correlate with their practices against DF. Use of mosquito-eating fish, screen windows, and dengue vaccine were protective factors against DF. Conclusion: The study highlights the importance of behavioral change for knowledge and attitude to have significant effect to practices against DF. Thus, we recommend two comprehensive health programs, Communication for Behavioral Impact (COMBI) and Health Belief Model (HBM).
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5

Ligsay, Antonio D., Kristan Jela M. Tambio, Michelle Joyce M. Aytona, Grecebio Jonathan D. Alejandro, Zypher Jude G. Regencia, Emmanuel S. Baja, and Richard Edward L. Paul. "Assessing Entomological and Epidemiological Efficacy of Pyriproxyfen-Treated Ovitraps in the Reduction of Aedes Species: A Quasi-Experiment on Dengue Infection Using Saliva Samples." International Journal of Environmental Research and Public Health 19, no. 5 (March 4, 2022): 3026. http://dx.doi.org/10.3390/ijerph19053026.

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Our study assessed the impact of using ovitraps with pyriproxyfen on mosquito populations and the feasibility of using human saliva samples to test for seroconversion to dengue virus (DENV). We used a quasi-experimental research design by forming the intervention (n = 220) and the control (n = 223) groups in neighboring Taguig City, Philippines, over 4 months. Socio-demographic data, entomological indices, and IgG antibodies against DENV were measured. Associations between the implementation of ovitraps dosed with pyriproxyfen and mosquito densities (percentage positive ovitraps and container indices) and DENV seroconversion were calculated post-intervention in Months 2, 3, and 4. Among the participants recruited at baseline, 17 and 13 were seropositive for dengue (DENV) in the intervention and control groups, respectively. Both entomological indices were lower in the treated area than the control site at post-intervention Months 2, 3, and 4, but not earlier. Dengue seroconversions rates decreased in the treated population, but not significantly so. In conclusion, the use of PPF-treated ovitraps may have impacted the mosquito population, but not seroconversion rates. Compliance in providing saliva samples and the ability to detect IgG antibodies within these samples was encouraging and suggests that further studies on larger populations for longer durations are warranted.
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6

Ligsay, Antonio D., Zypher Jude G. Regencia, Kristan Jela M. Tambio, Michelle Joyce M. Aytona, Alain Jason A. Generale, Grecebio Jonathan D. Alejandro, Jacquiline S. Tychuaco, Lilian A. De las Llagas, Emmanuel S. Baja, and Richard Edward L. Paul. "Efficacy Assessment of Autodissemination Using Pyriproxyfen-Treated Ovitraps in the Reduction of Dengue Incidence in Parañaque City, Philippines: A Spatial Analysis." Tropical Medicine and Infectious Disease 8, no. 1 (January 16, 2023): 66. http://dx.doi.org/10.3390/tropicalmed8010066.

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Dengue is one of the most important vector-borne diseases worldwide and is a significant public health problem in the tropics. Mosquito control continues to be the primary approach to reducing the disease burden and spread of dengue virus (DENV). Aside from the traditional larviciding and adulticiding interventions, autodissemination using pyriproxyfen-treated (AD-PPF) ovitraps is one of the promising methods to complement existing vector control strategies. Our paper assessed the efficacy of AD-PPF in reducing DENV infections in two barangays in Parañaque City. Using saliva samples from the participants from both the control and intervention sites, we collected the seroprevalence data for three months in each of the two years. Spatial analysis was conducted to determine hotspot areas and identify DENV infection distributions across the trial periods. The results showed that the intervention site was identified as having a clustering of DENV infections in Month 0 of Year 1 and shifted to a random dispersion of dengue cases at the end of Month 3 in Year 2. The disappearance of the clustering of the intervention site translates to a decrease in the cases of DENV infection relative to the control site. Furthermore, we also identified that DENV transmission occurred at a small-scale level that did not go beyond 86 m. In conclusion, AD-PPF is suggested to be an effective strategy and may be used as an additional vector control approach, albeit based on this short-term implementation.
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7

Murphy, Amanda K., Ferdinand V. Salazar, Ryan Bonsato, Gemma Uy, Antonietta P. Ebol, Royfrextopher P. Boholst, Callan Davis, et al. "Climate variability and Aedes vector indices in the southern Philippines: An empirical analysis." PLOS Neglected Tropical Diseases 16, no. 6 (June 14, 2022): e0010478. http://dx.doi.org/10.1371/journal.pntd.0010478.

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Background Vector surveillance is an essential public health tool to aid in the prediction and prevention of mosquito borne diseases. This study compared spatial and temporal trends of vector surveillance indices for Aedes vectors in the southern Philippines, and assessed potential links between vector indices and climate factors. Methods We analysed routinely collected larval and pupal surveillance data from residential areas of 14 cities and 51 municipalities during 2013–2018 (House, Container, Breteau and Pupal Indices), and used linear regression to explore potential relationships between vector indices and climate variables (minimum temperature, maximum temperature and precipitation). Results We found substantial spatial and temporal variation in monthly Aedes vector indices between cities during the study period, and no seasonal trend apparent. The House (HI), Container (CI) and Breteau (BI) Indices remained at comparable levels across most surveys (mean HI = 15, mean CI = 16, mean BI = 24), while the Pupal Productivity Index (PPI) was relatively lower in most months (usually below 5) except for two main peak periods (mean = 49 overall). A small proportion of locations recorded high values across all entomological indices in multiple surveys. Each of the vector indices were significantly correlated with one or more climate variables when matched to data from the same month or the previous 1 or 2 months, although the effect sizes were small. Significant associations were identified between minimum temperature and HI, CI and BI in the same month (R2 = 0.038, p = 0.007; R2 = 0.029, p = 0.018; and R2 = 0.034, p = 0.011, respectively), maximum temperature and PPI with a 2-month lag (R2 = 0.031, p = 0.032), and precipitation and HI in the same month (R2 = 0.023, p = 0.04). Conclusions Our findings indicated that larval and pupal surveillance indices were highly variable, were regularly above the threshold for triggering vector control responses, and that vector indices based on household surveys were weakly yet significantly correlated with city-level climate variables. We suggest that more detailed spatial and temporal analyses of entomological, climate, socio-environmental and Aedes-borne disease incidence data are necessary to ascertain the most effective use of entomological indices in guiding vector control responses, and reduction of human disease risk.
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8

van Panhuis, Willem G., Marc Choisy, Xin Xiong, Nian Shong Chok, Pasakorn Akarasewi, Sopon Iamsirithaworn, Sai K. Lam, et al. "Region-wide synchrony and traveling waves of dengue across eight countries in Southeast Asia." Proceedings of the National Academy of Sciences 112, no. 42 (October 5, 2015): 13069–74. http://dx.doi.org/10.1073/pnas.1501375112.

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Dengue is a mosquito-transmitted virus infection that causes epidemics of febrile illness and hemorrhagic fever across the tropics and subtropics worldwide. Annual epidemics are commonly observed, but there is substantial spatiotemporal heterogeneity in intensity. A better understanding of this heterogeneity in dengue transmission could lead to improved epidemic prediction and disease control. Time series decomposition methods enable the isolation and study of temporal epidemic dynamics with a specific periodicity (e.g., annual cycles related to climatic drivers and multiannual cycles caused by dynamics in population immunity). We collected and analyzed up to 18 y of monthly dengue surveillance reports on a total of 3.5 million reported dengue cases from 273 provinces in eight countries in Southeast Asia, covering ∼107 km2. We detected strong patterns of synchronous dengue transmission across the entire region, most markedly during a period of high incidence in 1997–1998, which was followed by a period of extremely low incidence in 2001–2002. This synchrony in dengue incidence coincided with elevated temperatures throughout the region in 1997–1998 and the strongest El Niño episode of the century. Multiannual dengue cycles (2–5 y) were highly coherent with the Oceanic Niño Index, and synchrony of these cycles increased with temperature. We also detected localized traveling waves of multiannual dengue epidemic cycles in Thailand, Laos, and the Philippines that were dependent on temperature. This study reveals forcing mechanisms that drive synchronization of dengue epidemics on a continental scale across Southeast Asia.
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Balingit, Jean Claude, Thaddeus M. Carvajal, Mariko Saito-Obata, Maribet Gamboa, Amalea Dulcene Nicolasora, Ava Kristy Sy, Hitoshi Oshitani, and Kozo Watanabe. "Surveillance of dengue virus in individual Aedes aegypti mosquitoes collected concurrently with suspected human cases in Tarlac City, Philippines." Parasites & Vectors 13, no. 1 (November 25, 2020). http://dx.doi.org/10.1186/s13071-020-04470-y.

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Abstract Background Vector control measures are critical for the prevention and reduction of dengue virus (DENV) transmission. Effective vector control is reliant not only on knowledge of mosquito abundance, but also on the timely and accurate detection of mosquito-borne infection. Mosquito-based virus surveillance programs typically rely on pool-based mosquito testing, although whether individual-based mosquito testing is a feasible alternative to this has not been widely studied. Applying an individual-based mosquito testing approach, we conducted a 1-month surveillance study of DENV in adult Aedes aegypti mosquitoes in homes of suspected dengue patients during the 2015 peak dengue season in Tarlac City, Philippines to more accurately assess the mosquito infection rate and identify the DENV serotypes and genotypes concurrently co-circulating in mosquitoes and patients there. Methods We performed a one-step multiplex real-time reverse transcription-polymerase chain reaction (RT-PCR) assay for the simultaneous detection and serotyping of DENV in patients and individual female Ae. aegypti mosquitoes. Additionally, we performed sequencing and phylogenetic analyses to further characterize the detected DENV serotypes in mosquitoes and patients at the genotype level. Results We collected a total of 583 adult Ae. aegypti mosquitoes, of which we individually tested 359 female mosquitoes for the presence of DENV. Ten (2.8%) of the 359 female mosquitoes were positive for the presence of DENV. We detected DENV-1, DENV-2, and DENV-4 in the field-collected mosquitoes, which was consistent with the serotypes concurrently found in infected patients. Sequencing and phylogenetic analyses of the detected DENV serotypes based on the partial sequence of the evelope (E) gene revealed three genotypes concurrently present in the sampled mosquitoes and patients during the study period, namely DENV-1 genotype IV, DENV-2 Cosmopolitan genotype, and DENV-4 genotype II. Conclusions We demonstrated the utility of a one-step multiplex real-time RT-PCR assay for the individual-based DENV surveillance of mosquitoes. Our findings reinforce the importance of detecting and monitoring virus activity in local mosquito populations, which are critical for dengue prevention and control.
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10

Subido, Michael E., and Imelda S. Aniversario. "A Correlation Study between Dengue Incidence and Climatological Factors in the Philippines." Asian Research Journal of Mathematics, December 22, 2022, 110–19. http://dx.doi.org/10.9734/arjom/2022/v18i12630.

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Dengue is a viral mosquito-borne infection transmitted primarily by the Aedes mosquitoes. It is one of the several emerging tropical diseases which progressively spread geographically to virtually all tropical countries like the Philippines. Recent climate changes related to global warming have increased the potential risk of dengue outbreaks in the world. In this paper, we study and investigate temperature and precipitation as climatological factors affecting dengue incidence in the Philippines from the year 2015 to 2018. Monthly dengue cases and climate data were gathered for the said study period. A correlation and wavelet coherence analyses were performed to determine a relationship between dengue incidence and climatological factors in the Philippines. Results show that the amount of rainfall is strongly correlated to the increase of dengue cases in the country as compared to the temperature. Evidence shows that dengue incidence in the Philippines mostly occur during the rainy season. Thus, intensified surveillance and control of mosquitoes during the rainy season are recommended.
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11

Mistica, Myra S., Virginia R. Ocampo, Lilian A. De Las Llagas, Arlene G. Bertuso, Fe D. Alzona, and Ester A. Magsino. "A Survey of Mosquito Species in Public Schools of Metro Manila, Philippines Using Ovitraps as Surveillance Tool." Acta Medica Philippina 53, no. 4 (August 30, 2019). http://dx.doi.org/10.47895/amp.v53i4.40.

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Objective. This study assessed the species composition of mosquitoes collected from ovitraps in selected public schools of Metro Manila, Philippines. Materials and Methods. Ovitraps were installed from November 2013 to February 2014, in purposively selected public elementary and high schools of Metro Manila. Ovitraps were installed inside classrooms and collected weekly and examined for mosquito eggs and larvae. Speciation was done once a month from November 2013 to February 2014. All positive paddles were immersed in water for larval emergence, reared to fourth instars and were identified using taxonomic keys. Results. A total of 1,482 ovitraps were installed in the selected public schools, and 18,325 larvae were collected from elementary schools, while 16,670 larvae were collected from high schools.The mean ovitrap index or infestation rate was 49.69% during the period of data collection. Mosquito larvae were identified as Aedes aegypti (88.94%) and Aedes albopictus (11.06%). Aedes aegypti and Aedes albopictus coexisted in some of the examined paddles. No significant differences were observed between the type of school and the presence of Aedes larvae. Significant differences were observed between total number of mosquito larvae and months of collection. Conclusion. The presence of Aedes mosquitoes in schools evidently shows that continuous vector surveillance in schools is necessary as this information will help in the formulation of proactive vector control activities, thereby preventing the occurrence of mosquito-borne diseases.
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12

Rivera, MD, PhD, Pilarita T. "Editorial." Acta Medica Philippina 53, no. 4 (August 30, 2019). http://dx.doi.org/10.47895/amp.v53i4.55.

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The epidemiology of vector mosquito-borne diseases such as malaria and dengue defines the interface between mosquito to human, and that between human to mosquito, as well as multiple economic, social, cultural, political and behavioral factors that expose humans to the mosquito bite, resulting in infection. Environmental factors such as suitable mosquito breeding sites, tropical climate and topography, increase mosquito density and man biting behavior resulting in infection and transmission. Different interventions to kill vector mosquitoes (adulticides and larvicides), prevent the mosquito bite (insecticide treated nets, curtains, repellents), diagnosis (rapid tests) and treatment (ACTs for malaria), have been implemented, and have been shown to reduce morbidity and mortality particularly for malaria. But can disease control be realized and sustained? Can disease elimination and prevention of re-introduction be achieved? A better understanding of the epidemiology and control of vector-borne diseases clearly shows that the responsibility is not with key affected populations and the health sector only, but with all those sectors and stakeholders that impact on the disease, be it at the local and national levels. This is the basis of creating and implementing intersectoral collaborations (ISCs) for vector-borne diseases. The article was able to draw together and analyzed multi-country experiences on ISCs for malaria and dengue. The ISC structure, goals, inputs and outputs as well as outcomes of existing models were described. Gaps in planning and implementation were noted, and recommendations were added. The resulting data can be used to develop an enhanced ISC framework for more effective implementation and success. The Philippines had quite a number of malaria control initiatives built on partnerships with bilateral agencies- USAID, USNAMRU, WHO, JICA, AusAID, NGOs, private corporations, religious organizations, military, and that have contributed in disease control.1 Notable are the Palawan and Agusan del Sur experiences. In 1999, the Palawan provincial government and Pilipinas Shell Foundation, as its corporate social responsibility, established Kilusan Ligtas Malaria to control malaria in the island.2,3 The program’s multi-sectoral and social mobilization strategies that have been adopted by Global Fund have resulted in impressive decline of malaria cases and deaths, even to this time. High social capital may ensure the sustainability of these strategies.4,5 In 1995, Agusan del Sur, another malarious province, implemented the project “Implementation and Evaluation of a Self-Sustaining Community-Based Malaria Control Program in the Philippines” through the Australian International Development and Assistance Bureau. Initially a collaborative project of RITM and DOH-Malaria Control Services, it was gradually devolved to the Province of Agusan del Sur, which created its Provincial Technical Advisory Committee, Provincial Management Team and Community Trust Fund to implement and sustain malaria control.6 Last year, Agusan del Sur was declared malaria-free. How to be successful may not be elusive and enhanced Intersectoral Collaborations may be the winning formula in the fight against malaria and other vector-borne diseases.REFERENCES 1. Tongol-Rivera P. Milestones in the history of malaria research and control in the Philippines. In: Kano S, Tongol-Rivera P, eds. Malaria in Asia. Asian Parasitology Series Monograph The Federation of Asian Parasitologists. 2005; 6:135-166. 2. Angluben RU, Trudeau MR, Kano S, Tongol-Rivera P. Kilusan Ligtas Malaria: Advancing Social Mobilization towards Sustainable Malaria Control in the province of Palawan, the Philippines. Trop Med Health. 2008; 36(1):45-9. 3. Matsumoto-Takahashi ELA, Tongol-Rivera P, Villacorte EA, Angluben RU, Jimba M, Kano S. Bottom-up approach to strengthen community-based malaria control strategy from community health workers’ perceptions of their past, present, and future: a qualitative study in Palawan, Philippines. 2018. Trop Med Health. 2018; 46(1):24. 4. Tongol-Rivera P, Kano S, Saniel O, Solon JA, Villacorte E. Social Capital and Malaria Control in Palawan, the Philippines. 2010 (unpublished). 5. Valdecanas OC, Tuazon RR, Barcelona DR. Understanding Social Mobilization. In: The Philippine Experience, How Social Mobilization Works. UNICEF, the Philippines. 1996; pp. 9-19. 6. Linao RT. Finding and Funding Means: Beyond the Elimination of Malaria in Agusan del Sur. Foundation for the Development of Agusanons, Inc. 2014. Pilarita T. Rivera, MD, PhD Associate Editor Department of Parasitology College of Public Health University of the Philippines Manila REFERENCES 1. Tongol-Rivera P. Milestones in the history of malaria research and control in the Philippines. In: Kano S, Tongol-Rivera P, eds. Malaria in Asia. Asian Parasitology Series Monograph The Federation of Asian Parasitologists. 2005; 6:135-166.2. Angluben RU, Trudeau MR, Kano S, Tongol-Rivera P. Kilusan Ligtas Malaria: Advancing Social Mobilization towards Sustainable Malaria Control in the province of Palawan, the Philippines. Trop Med Health. 2008; 36(1):45-9.3. Matsumoto-Takahashi ELA, Tongol-Rivera P, Villacorte EA, Angluben RU, Jimba M, Kano S. Bottom-up approach to strengthen community-based malaria control strategy from community health workers’ perceptions of their past, present, and future: a qualitative study in Palawan, Philippines. 2018. Trop Med Health. 2018; 46(1):24.4. Tongol-Rivera P, Kano S, Saniel O, Solon JA, Villacorte E. Social Capital and Malaria Control in Palawan, the Philippines. 2010 (unpublished).5. Valdecanas OC, Tuazon RR, Barcelona DR. Understanding Social Mobilization. In: The Philippine Experience, How Social Mobilization Works. UNICEF, the Philippines. 1996; pp. 9-19. 6. Linao RT. Finding and Funding Means: Beyond the Elimination of Malaria in Agusan del Sur. Foundation for the Development of Agusanons, Inc. 2014.
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Haroon-Or-Rashid, Md, Md Monowar Hossen Patwary, Md Tariquzzaman, Ahmed Imtiaz, and M. N. Rubaia Islam Bony. "Chikungunya Virus: An Emerging Threat to South East Asia Region." Asian Journal of Research in Infectious Diseases, July 10, 2018, 1–9. http://dx.doi.org/10.9734/ajrid/2018/v1i113946.

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Chikungunya virus is an alphavirus of the Togaviridae family, positive-strand RNA genome, which was first recorded in Tanzania in 1952 and since then Chikungunya has been reported in Burma, Bangladesh, Thailand, Cambodia, Vietnam, India, Sri Lanka, Indonesia, West Africa and the Philippines. In the recent decade, Chikungunya is a severe global public health concern. Chikungunya predominantly transmitted by bites of mosquitoes of the Aedes genus (Aedes aegypti and Aedes albopictus) the same mosquito that transmits Dengue fever, only female mosquitoes are infective because they require a blood meal for the formation of the egg. Vertical transmission occurs between mother and fetus. The infected Chikungunya mosquitoes can be found for biting throughout daylight hours especially early morning and late afternoon. The Chikungunya viral disease occurs in victims of all ages in both sexes. Following a bite by an infected mosquito, the disease manifests itself after an average incubation period of 2-4 days (range: 3-12 days), predominant clinical features include, high fever, joint pain, rash, myalgia etc. Serum specimen is collected within 5 days for the Reverse Transcriptase- Polymerase Chain Reaction (RT –PCR) to detect the viral RNA and ELISA/ICT detect anti-Chikungunya antibody (IgM and IgG) after 1st weak of infection. Specific treatment and a recognised vaccine are not available for Chikungunya, but symptomatic treatments are available like paracetamol and painkiller for high fever and local pain. Elimination of mosquito habitats is the best way to prevent and control of Chikungunya infection.
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Obra, Glenda, Eleanor Rebua, Abigaile Mia Hila, Sotero Resilva, Rosemary Lees, and Wadaka Mamai. "Ovitrap Monitoring of Aedes aegypti and Aedes albopictus in Two Selected Sites in Quezon City, Philippines." Philippine Journal of Science 151, no. 5 (August 25, 2022). http://dx.doi.org/10.56899/151.05.38.

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In recent years, Aedes mosquitoes have become a serious health threat in the Philippines, causing a dramatic increase in dengue incidence. To design and implement adapted vector control measures, knowledge of vector composition and abundance is essential. Surveillance of mosquito populations using ovitraps was conducted for about two years (from April 2018–February 2020) in two selected sites (Sitio Payong and Villa Beatriz in Old Balara, Quezon City). These areas were identified as potential sites for small-scale pilot trials of the sterile insect technique. Aedes aegypti and Ae. albopictus were present in both sites, but Ae. aegypti was about 20 times more abundant than Ae. albopictus. There was a significant difference between the two sites in the number of eggs collected weekly but not in the OI. The number of Aedes spp. eggs collected were found to positively correlate with the maximum daily temperature. These data provide comprehensive, evidence- based information that will help in the design and implementation of Aedes control measures, as part of wider public health interventions for prevention and control.
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15

Bentoy, Kristine Mae, Stephanie Sayson, Dan Anthony Bataan, and Frances Edillo. "Zea mays (L.) Pollen as Nutriment to Aedes aegypti (Diptera: Culicidae) Larvae under Laboratory Conditions." Annals of Tropical Research, April 7, 2015, 69–83. http://dx.doi.org/10.32945/atr3715.2015.

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This study investigated if maize (Zea mays Linnaeus) pollen can serve as a nutrient source to Aedes aegypti Linnaeus larvae, the primary dengue mosquito vector in the Philippines. First instar larvae of Ae. aegypti were subjected to different treatments of maize pollen reared in mineral water or in rain water to determine their effects on the larval development into adult emergence. Results showed that the overall development time, survivorship, and mean duration of sub adult stages differed (P <0.05; univariate ANOVA) but not on wing length among the treatments of Ae. aegypti. Larvae fed with maize pollen and reared in rain water took 7.36 d to emerge into adults and had 65% survivorship, whereas those reared in mineral water took 7.88 d to become adults and had 62% survivorship. Larvae in positive control took 6.05 d to become adults and had 79% survivorship. Mean duration from first to third instar larval stages differed (P<0.05) among treatments. Post hoc analysis using Scheffe's pairwise comparison test showed that larvae fed with maize pollen and reared in rain water did not significantly differ (P>0.05) from the positive control (fishfood) on their development time, survivorship, and mean duration of subadult stages. These suggest that maize pollen provides nutrients for Ae. aegypti larvae similar to the positive control. Carbohydrates and proteins were detected in Molisch, Iodine, and Biuret tests. Results are relevant for future work in establishing the link between dengue mosquitoes and maize plantations in the Philippines.
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16

"BIOBOARD." Asia-Pacific Biotech News 18, no. 12 (December 2014): 4–15. http://dx.doi.org/10.1142/s0219030314000822.

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INDIA – Stem cell therapy is ‘no remedy for stroke’. THE PHILIPPINES – Farmers losing from GM eggplant ban, says expert. SINGAPORE – Breakthrough discovery by researchers contributes towards future treatment of multiple sclerosis and autoimmune inflammation. VIETNAM – Some Asians found to carry gene resistant to typhoid. VIETNAM – Vietnam eyes water-saving technology for its rice farms. AFRICA – South Africa's healthcare ‘still burdened with diseases’. AFRICA – Healthcare workers use buddy system to fight Ebola. AFRICA – STI ministerial summit appeals for Africa-led research. BANGLADESH – Jute as possible arsenic remover in Bangladesh. EGYPT – Interest grows in unusual Egyptian method of mosquito control. EUROPE – Research team proves the efficacy of new drug against stem cells that provoke the onset and growth of cancer and its metastasis. UNITED STATES – Protein predicts response to new immunotherapy drug. UNITED STATES – A link between DNA transcription and disease causing expansions which lead to hereditary disorders. UNITED STATES – Penn Medicine team develops cognitive test battery to assess the impact of long duration spaceflights on astronauts' brain function. UNITED STATES – Survival differences seen for advanced-stage laryngeal cancer. UNITED STATES – Mosquitoes and malaria: Scientists pinpoint how biting cousins have grown apart.
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17

Khormi, Hassan M., and Lalit Kumar. "Future malaria spatial pattern based on the potential global warming impact in South and Southeast Asia." Geospatial Health 11, no. 3 (November 21, 2016). http://dx.doi.org/10.4081/gh.2016.416.

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We used the Model for Interdisciplinary Research on Climate-H climate model with the A2 Special Report on Emissions Scenarios for the years 2050 and 2100 and CLIMEX software for projections to illustrate the potential impact of climate change on the spatial distributions of malaria in China, India, Indochina, Indonesia, and The Philippines based on climate variables such as temperature, moisture, heat, cold and dryness. The model was calibrated using data from several knowledge domains, including geographical distribution records. The areas in which malaria has currently been detected are consistent with those showing high values of the ecoclimatic index in the CLIMEX model. The match between prediction and reality was found to be high. More than 90% of the observed malaria distribution points were associated with the currently known suitable climate conditions. Climate suitability for malaria is projected to decrease in India, southern Myanmar, southern Thailand, eastern Borneo, and the region bordering Cambodia, Malaysia and the Indonesian islands, while it is expected to increase in southern and south-eastern China and Taiwan. The climatic models for <em>Anopheles</em> mosquitoes presented here should be useful for malaria control, monitoring, and management, particularly considering these future climate scenarios.
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18

Reyes, Eriko Lois, Marvin Menor, Michelle Munsayac, John Bryan Notario, Gianne Henriette Ogaco, Jueliand Peter Perez, Eleanor Kay Ramos, Susan Geraldine Tengco, Phyllis Rio, and Allan Hilario. "Mosquito Repellent Property of “Ylang-Ylang” (Cananga odorata) Essential Oil in Urea-Formaldehyde Microencapsulated Cotton Fabric." Philippine Journal of Science 149, no. 4 (September 15, 2020). http://dx.doi.org/10.56899/149.04.02.

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Common mosquito-borne diseases in the Philippines include dengue, Chikungunya, Japanese encephalitis, malaria, and filariasis. Mosquito repellents are effective protective measures against mosquito bites and microencapsulation of essential oils to fabric is currently an emerging trend for mosquito repellency. Accordingly, “ylang-ylang” (Cananga odorata) is a fast-growing tree endemic to the Philippines and found to have mosquito repellent properties. This study aimed to determine the mosquito repellency of microencapsulated ylang-ylang oil applied to cotton fabrics. The difference in the mosquito repellent property between untreated and treated fabrics in different concentrations of microencapsulated ylang-ylang oil was tested. The prepared microcapsules containing 10 mL and 2.5 mL ylang-ylang oil were applied to separate cotton fabrics using a bath exhaustion method. The fabrics were examined using a scanning electron microscope and showed irregularly shaped and rough-walled microcapsules with sizes ranging 50–100 μm. The fabrics were then tested for mosquito repellency using the World Health Organization (WHO) cone test in five replicates. An untreated fabric served as negative control. The test of significance used the one-way analysis of variance (ANOVA), and the p-value was set at p < 0.05. The fabrics treated with 10 mL and 2.5 mL microcapsules showed increasing rates of mosquito repellency from 80 ± 10% to 88 ± 8.37% and from 64 ± 5.48% to 82 ± 8.37%, respectively (p < 0.05). The mosquito percent repellency showed a significantly higher % repellency in treated than the untreated fabric (p < 0.05). The fabric with microcapsules containing 10 mL of ylang-ylang oil has greater mosquito repellency than that of 2.5 mL (p < 0.05). In conclusion, this study suggests the potential of urea-formaldehyde microencapsulation as an effective method in making cotton fabrics with mosquito repellent properties using ylang-ylang (Cananga odorata) essential oil.
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Edillo, Frances, Rhoniel Ryan Ymbong, Alyssa Angel Bolneo, Ric Jacob Hernandez, Bianca Louise Fuentes, Garren Cortes, Joseph Cabrera, Jose Enrico Lazaro, and Anavaj Sakuntabhai. "Temperature, season, and latitude influence development-related phenotypes of Philippine Aedes aegypti (Linnaeus): Implications for dengue control amidst global warming." Parasites & Vectors 15, no. 1 (March 5, 2022). http://dx.doi.org/10.1186/s13071-022-05186-x.

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Abstract Background Dengue is endemic in the Philippines. Aedes aegypti is the primary vector. This study aimed to determine the hatching behavior and viability of Ae. aegypti first-generation (F1) eggs when exposed to temperature and photoperiod regimes under laboratory conditions. Methods Parental eggs were collected from selected highland and lowland sites in the Philippine big islands (Luzon, Visayas, and Mindanao) during the wet (2017–2018) and dry (2018) seasons. F1 egg cohorts were exposed separately in environmental chambers at 18, 25, and 38 °C with respective photoperiods for 6 weeks. Phenotypes (percent pharate larvae [PPL], hatch rates [HRs], and reproductive outputs [ROs]) were determined. Results Results of multivariate analyses of variance (MANOVA) between seasons showed significant main effects of temperature, season, and big island on all phenotypes across all sites. Significant interaction effects between seasons on all phenotypes across sites were shown between or among (1) season and big island, (2) season and temperature, (3) big island and temperature, (4) season, big island, and temperature, (5) big island, altitude, and temperature, and (6) season, big island, altitude, and temperature. Factors associated with the big islands might include their ecology, available breeding sites, and day lengths due to latitudinal differences, although they were not measured in the field. MANOVA results within each season on all phenotypes across sites showed (1) significant main effects of big island and temperature, and (2) significant interaction effects between big island and temperature within the wet season and (3) between temperature and photoperiod within the dry season. PPL were highest at 18 °C and were formed even at 38 °C in both seasons. Pharate larvae might play an adaptive role in global warming, expanded distribution to highlands, and preponderance to transmit human diseases. HRs in both seasons were highest at 25 °C and lowest at 38 °C. ROs were highest at 25 °C in the wet season and at 18 °C in the dry season. Conclusions Temperature and latitude of Philippine big islands influenced the development-related phenotypes of Ae. aegypti in both seasons. The two seasons influenced the phenotypes and their interaction effects with big island and/or temperature and/or altitude. Recommendations include year-round enhanced 4S control strategies for mosquito vectors and water pipeline installation in rural highlands. Graphical Abstract
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20

"BIOBOARD." Asia-Pacific Biotech News 18, no. 02 (February 2014): 4–20. http://dx.doi.org/10.1142/s021903031400010x.

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INDONESIA – Alleged cure for dengue in Indonesia stirs debate. JAPAN – Daiichi Sankyo submits SAVAYSATM tablets new drug application to the U.S. FDA. MALAYSIA – Marine bacterial compound shows antiviral potential. THE PHILIPPINES – Rice bias in the Philippines ‘neglects soil problems’. SINGAPORE – Start-up market's artificial cell membranes can speed up drug discovery. SINGAPORE – NCCS scientists discover gene regulation is dependent on protein. SINGAPORE – Elephant shark genome provides new insights into bone formation and adaptive immunity in humans. SINGAPORE – Vela Diagnostics launches qualitative test to identify never before documented virus in Western hemisphere. SINGAPORE – New discovery of biomarker to improve diagnosis, prognosis and treatment of esophageal squamous cell carcinoma. VIETNAM – Setback for dengue-blocking mosquito trial in Vietnam. AFRICA – Scientists to create disease-resistant Ethiopian enset. AFRICA – Viral load tests ‘could transform HIV treatment failure’. EUROPE – QIAGEN and Exosome Diagnostics to develop first-in-class, non-invasive diagnostics for key genetic biomarkers in lung and other cancers. EUROPE – Study examines probiotic use in preventing gastrointestinal disorders in infants. EUROPE – Gecko Biomedical's co-founders demonstrate a ‘bio-inspired’ tissue adhesive that shows promise for minimally invasive heart surgery and vessel repair. UNITED STATES – Scientists solve 40-year mystery of how sodium controls opioid brain signaling. UNITED STATES – Scripps Florida scientists identify possible key to drug resistance in Crohn's disease. UNITED STATES – On-demand vaccines possible with engineered nanoparticles. UNITED STATES – Odor receptors discovered in lungs. UNITED STATES – New technique targets specific areas of cancer cells with different drugs.
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Sarker, Md Moklesur Rahman, Farzana Khan, and Isa Naina Mohamed. "Dengue Fever: Therapeutic Potential of Carica papaya L. Leaves." Frontiers in Pharmacology 12 (April 26, 2021). http://dx.doi.org/10.3389/fphar.2021.610912.

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Dengue, a very widespread mosquito-borne infectious disease caused by Aedes aegypti virus, has been occurring during the monsoons every year. The prevalence and incidence of dengue fever and death due to its complications have been increased drastically in these recent years in Bangladesh, Philippines, Thailand, Brazil, and India. Recently, dengue had spread in an epidemic form in Bangladesh, Thailand, and Philippines. Although the infection affected a large number of people around the world, there is no established specific and effective treatment by synthetic medicines. In this subcontinent, Malaysia could effectively control its incidences and death of patients using alternative medication treatment mainly prepared from Carica papaya L. leaves along with proper care and hospitalization. Papaya leaves, their juice or extract, as well as their different forms of preparation have long been used traditionally for treating dengue fever and its complications to save patients’ lives. Although it is recommended by traditional healers, and the general public use Papaya leaves juice or their other preparations in dengue fever, this treatment option is strictly denied by the physicians offering treatment in hospitals in Bangladesh as they do not believe in the effectiveness of papaya leaves, thus suggesting to patients that they should not use them. In Bangladesh, 1,01,354 dengue patients have been hospitalized, with 179 deaths in the year 2019 according to information from the Institute of Epidemiology, Disease Control, and Research as well as the Directorate General of Health Services of Bangladesh. Most of the patients died because of the falling down of platelets to dangerous levels and hemorrhage or serious bleeding. Therefore, this paper aims to critically review the scientific basis and effectiveness of Carica papaya L. leaves in treating dengue fever based on preclinical and clinical reports. Thrombocytopenia is one of the major conditions that is typical in cases of dengue infection. Besides, the infection and impairment of immunity are concerned with dengue patients. This review summarizes all the scientific reports on Carica papaya L. for its ability on three aspects of dengue: antiviral activities, prevention of thrombocytopenia and improvement of immunity during dengue fever.
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"Bioboard." Asia-Pacific Biotech News 13, no. 02 (February 2009): 5–22. http://dx.doi.org/10.1142/s0219030309000093.

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AUSTRALIA – Mosquito Parasite Could Control Dengue CHINA – China has Twice the Global Average of Drug-Resistant Tuberculosis CHINA – 80 000 Antibiotics Abuse-related Deaths Annually CHINA – Bird Flu Found in Chicken from China CHINA – China on Alert following Bird Flu Death CHINA – Chinese Dairies to Compensate Tainted Milk Victims' Families CHINA – New Insulin Resistance Tricks Found CHINA – World's First Plant Chromosome Atlas CHINA – Project Launched to Study Structure of Proteins CHINA – Fake Diabetes Drug Linked to Two Deaths CHINA – Birth Defects Rising in Polluted China INDIA – India Culls Poultry in Darjeeling After Bird Flu INDIA – India Introduces Second-Line Anti-retroviral Treatment in Eight States INDIA – Indian Medical Tourism to Reach US$1.9 billion by 2015 INDIA – Canadian and Indian Ministers Sign Pact on Agriculture Cooperation INDIA – 6000 year-old Rice Species Discovered in Meghalaya INDIA – Genetics to Help Conserve Rare Bird Species JAPAN – Coating the Protein Enhances Disease-fighting Capability JAPAN – Scientists Isolate Genes that Made 1918 Flu Lethal JAPAN – Researchers in Japan Develop All-round Flu Vaccine PHILIPPINES – Ebola Reston Virus Found in Filipino Farm Worker SINGAPORE – New Method to Create iPS Cells SINGAPORE – Ray of Hope for Liver Cancer Sufferers SINGAPORE – Bacteria Improve Energy and Cost Efficiency in Water Treatment TAIWAN – Secrets of “Speciation” Gene Unravelled TAIWAN – Initial Breakthrough in Poultry Vaccine Development TAIWAN – Taiwan Gains Direct Access to WHO VIETNAM – Doctors Report First Drug Hypersensitivity Syndrome VIETNAM – Public Advised Serious Caution Against Bird Flu NORTH AMERICA – Kids of Pregnant Drinking Mums will Like Booze NORTH AMERICA – High Functional Diversity in Mycobacterium Tuberculosis Driven By Genetic Drift And Human Demography NORTH AMERICA – Newly Discovered Tuberculosis Protein May Help Explain Bacterium's Resilience NORTH AMERICA – U.S. Patent For Diagnostic Technology Awarded To URMC, Lighthouse Biosciences EUROPE – Structure Mediating Spread of Antibiotic Resistance Discovered EUROPE – New EU Pesticide Regulations Could Undermine Battle against Malaria EUROPE – iPill – The Smart Drug Delivery that can “Call” the Doctor EUROPE – What Drives Locusts to Swarm
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