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Journal articles on the topic 'Mosquito populations'
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1
Williams, Adeline, Alexander Franz, William Reid, and Ken Olson. "Antiviral Effectors and Gene Drive Strategies for Mosquito Population Suppression or Replacement to Mitigate Arbovirus Transmission by Aedes aegypti." Insects 11, no. 1 (January 12, 2020): 52. http://dx.doi.org/10.3390/insects11010052.
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The mosquito vector Aedes aegypti transmits arthropod-borne viruses (arboviruses) of medical importance, including Zika, dengue, and yellow fever viruses. Controlling mosquito populations remains the method of choice to prevent disease transmission. Novel mosquito control strategies based on genetically manipulating mosquitoes are being developed as additional tools to combat arbovirus transmission. Genetic control of mosquitoes includes two basic strategies: population suppression and population replacement. The former aims to eliminate mosquito populations while the latter aims to replace wild populations with engineered, pathogen-resistant mosquitoes. In this review, we outline suppression strategies being applied in the field, as well as current antiviral effector genes that have been characterized and expressed in transgenic Ae. aegypti for population replacement. We discuss cutting-edge gene drive technologies that can be used to enhance the inheritance of effector genes, while highlighting the challenges and opportunities associated with gene drives. Finally, we present currently available models that can estimate mosquito release numbers and time to transgene fixation for several gene drive systems. Based on the recent advances in genetic engineering, we anticipate that antiviral transgenic Ae. aegypti exhibiting gene drive will soon emerge; however, close monitoring in simulated field conditions will be required to demonstrate the efficacy and utility of such transgenic mosquitoes.
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Wartono, Wartono, Mohammad Soleh, and Yuslenita Muda. "MATHEMATICAL MODEL OF DENGUE CONTROL WITH CONTROL OF MOSQUITO LARVAE AND MOSQUITO AFFECTED BY CLIMATE CHANGE." BAREKENG: Jurnal Ilmu Matematika dan Terapan 15, no. 3 (September 1, 2021): 417–26. http://dx.doi.org/10.30598/barekengvol15iss3pp417-426.
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Consider a SIR model for the spread of dengue hemorrhagic fever involving three populations, mosquito eggs, mosquitoes, and humans. The parameters of the SIR model were estimated using rainfall data and air temperature for the cities of Pekanbaru and Solok. The main aim of this paper is to determine the effect of mosquito larvae and adult mosquito control on the spread of the dengue virus. Numerical solutions were also presented by using the Runge-Kutta method of order 4. Based on the results, the SIR model was obtained by involving the control parameters of mosquito larvae and adult mosquitoes. Besides, the mosquito population is affected by changes in temperature, rainfall, and fog. Numerical simulations illustrate that the number of infected mosquitoes and infected humans is influenced by the parameters of the percentage of mortality of mosquito larvae and adult mosquitoes.
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Acquah-Lamptey, Daniel, and Roland Brandl. "Effect of a dragonfly (<i>Bradinopyga strachani</i> Kirby, 1900) on the density of mosquito larvae in a field experiment using mesocosms." Web Ecology 18, no. 1 (May 24, 2018): 81–89. http://dx.doi.org/10.5194/we-18-81-2018.
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Abstract. Laboratory experiments with food-deprived larvae of odonates suggested that these predators may have the potential to control mosquito populations. However, it remains unclear whether larvae of odonates co-occur with mosquito larvae in the field and whether larvae of odonates reduce the density of mosquito larvae in the field. We exposed 35 water-filled concrete containers in the field in shady and sunny conditions. Some of these containers were partially covered (for simplicity called closed containers, allowing only mosquitoes to lay eggs), whereas others remained open. The density of mosquito larvae was higher in shaded containers and in closed containers. The multivoltine odonate Bradinopyga strachani colonized open containers and the occurrence of these predators resulted in a clear reduction of the mosquito population. Our results indicate that increasing the colonization of water bodies by Bradinopyga strachani is a promising strategy for controlling populations of mosquitoes.
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Kaczmarek, Maria E., Nora L. Herzog, Maria G. Noval, John Zuzworsky, Zahir Shah, Waheed I. Bajwa, and Kenneth A. Stapleford. "Distinct New York City Aedes albopictus Mosquito Populations Display Differences in Salivary Gland Protein D7 Diversity and Chikungunya Virus Replication." Viruses 12, no. 7 (June 28, 2020): 698. http://dx.doi.org/10.3390/v12070698.
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In an increasingly interconnected world, the exposure and subsequent spread of emergent viruses has become inevitable. This is particularly true for Aedes (Ae.) mosquito-vectored viruses, whose range has increased over the past decade from tropical to temperate regions. However, it is unclear if all populations of Ae. mosquitoes in temperate New York City are able to successfully replicate and transmit arboviruses. To answer this question, we reared Ae. albopictus mosquitoes living in a temperate climate from three locations in New York City. We first sequenced the salivary antiviral protein D7 from individual mosquitoes in each population and found single nucleotide variants that are both shared and unique for each Ae. albopictus population. We then fed each population chikungunya virus (CHIKV) via an artificial blood meal. All three mosquito populations could be infected with CHIKV, yet viral titers differed between populations at 7 days post infection. Moreover, we found that these mosquitoes could transmit CHIKV to mice, and that virus RNA reached the saliva as early as two days post infection. Upon sequencing of the saliva CHIKV genomic RNA, we found mutations at sites correlated with increased transmission and virulence. These studies show that NYC Ae. albopictus populations can be infected with and transmit CHIKV, CHIKV is able to evolve in these mosquitoes, and that host salivary factors display population-specific diversity. Taken together, these studies highlight the need to study how distinct mosquito populations control viral infections, both at the virus and host level.
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Segu, Bhagya, Nicole Auchter Riese, Kim Thien Hong Nguyen, Michael Leung, and Pat Segu. "Review: Ocular Complications of Mosquito-Transmitted Diseases." Canadian Journal of Optometry 80, no. 2 (June 1, 2018): 17–22. http://dx.doi.org/10.15353/cjo.80.266.
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The World Health Organization estimates that 1 billion cases of infectious disease originate from vector transmission, resulting in several million deaths annually. Mosquitos are the primary vector for multiple diseases in humans that cause self-limiting to sight-threatening ocular complications and significant systemic illness. The 2015-2016 outbreak of the mosquito-borne Zika virus in North and South America brought to the forefront how quickly mosquitoes can spread disease between continents, especially among vulnerable patient populations. Optometrists should be familiar with the associated ocular complications in order to effectively diagnose, co-manage, treat, and educate patients who have been infected by mosquito-borne disease. This paper reviews the ocular manifestations of mosquito-transmitted diseases including Zika virus, West Nile virus, Malaria, Dengue fever, Chikungunya, and Dirofilaria.
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Cai, Li-Ming. "Dynamics of Wild and Sterile Mosquito Population Models with Delayed Releasing." International Journal of Bifurcation and Chaos 30, no. 11 (September 15, 2020): 2050218. http://dx.doi.org/10.1142/s0218127420502181.
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To reduce the global burden of mosquito-borne diseases, e.g. dengue, malaria, the need to develop new control methods is to be highlighted. The sterile insect technique (SIT) and various genetic modification strategies, have a potential to contribute to a reversal of the current alarming disease trends. In our previous work, the ordinary differential equation (ODE) models with different releasing sterile mosquito strategies are investigated. However, in reality, implementing SIT and the releasing processes of sterile mosquitos are very complex. In particular, the delay phenomena always occur. To achieve suppression of wild mosquito populations, in this paper, we reassess the effect of the delayed releasing of sterile mosquitos on the suppression of interactive mosquito populations. We extend the previous ODE models to the delayed releasing models in two different ways of releasing sterile mosquitos, where both constant and exponentially distributed delays are considered, respectively. By applying the theory and methods of delay differential equations, the effect of time delays on the stability of equilibria in the system is rigorously analyzed. Some sustained oscillation phenomena via Hopf bifurcations in the system are observed. Numerical examples demonstrate rich dynamical features of the proposed models. Based on the obtained results, we also suggest some new releasing strategies for sterile mosquito populations.
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Myer, Mark H., Chelsea M. Fizer, Kenneth R. Mcpherson, Anne C. Neale, Andrew N. Pilant, Arturo Rodriguez, Pai-Yei Whung, and John M. Johnston. "Mapping Aedes aegypti (Diptera: Culicidae) and Aedes albopictus Vector Mosquito Distribution in Brownsville, TX." Journal of Medical Entomology 57, no. 1 (August 10, 2019): 231–40. http://dx.doi.org/10.1093/jme/tjz132.
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Abstract Aedes mosquitoes are vectors of several emerging diseases and are spreading worldwide. We investigated the spatiotemporal dynamics of Aedes aegypti (Linnaeus) and Aedes albopictus (Skuse) mosquito trap captures in Brownsville, TX, using high-resolution land cover, socioeconomic, and meteorological data. We modeled mosquito trap counts using a Bayesian hierarchical mixed-effects model with spatially correlated residuals. The models indicated an inverse relationship between temperature and mosquito trap counts for both species, which may be due to the hot and arid climate of southern Texas. The temporal trend in mosquito populations indicated Ae. aegypti populations peaking in the late spring and Ae. albopictus reaching a maximum in winter. Our results indicated that seasonal weather variation, vegetation height, human population, and land cover determine which of the two Aedes species will predominate.
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Ahmad, Noor Afizah, Nancy M. Endersby-Harshman, Nur Ruqqayah Mohd Mazni, Nur Zatil Aqmar Mohd Zabari, Siti Nor Syazwani Amran, Muhammad Kamarul Ridhuan Ghazali, Mohd Arif Abdul Karim, et al. "Characterization of Sodium Channel Mutations in the Dengue Vector Mosquitoes Aedes aegypti and Aedes albopictus within the Context of Ongoing Wolbachia Releases in Kuala Lumpur, Malaysia." Insects 11, no. 8 (August 13, 2020): 529. http://dx.doi.org/10.3390/insects11080529.
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Specific sodium channel gene mutations confer target site resistance to pyrethroid insecticides in mosquitoes and other insects. In Aedes mosquito species, multiple mutations that contribute to resistance vary in their importance around the world. Here, we characterize voltage sensitive sodium channel (Vssc) mutations in populations of Aedesaegypti from Kuala Lumpur, Malaysia, and look at their persistence in populations affected by ongoing Wolbachia releases (a dengue control measure). We also describe a Vssc mutation in Aedesalbopictus (F1534L) found for the first time in Malaysia. We show that there are three predominant Vssc haplotypes in Aedesaegypti in this region, which all persist with regular backcrossing, thereby maintaining the original genetic composition of the populations. We identify changes in genotype frequency in closed populations of Ae. aegypti maintained for multiple generations in laboratory culture, suggesting different fitness costs associated with the genotypes, some of which may be associated with the sex of the mosquito. Following population replacement of Ae. aegypti by Wolbachia in the target area, however, we find that the Vssc mutations have persisted at pre-release levels. Mosquitoes in two genotype classes demonstrate a type I pyrethroid resistance advantage over wildtype mosquitoes when exposed to 0.25% permethrin. This resistance advantage is even more pronounced with a type II pyrethroid, deltamethrin (0.03%). The results point to the importance of these mutations in pyrethroid resistance in mosquito populations and the need for regular backcrossing with male mosquitoes from the field to maintain similarity of genetic background and population integrity during Wolbachia releases.
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O’Meara, Wendy Prudhomme, Ryan Simmons, Paige Bullins, Betsy Freedman, Lucy Abel, Judith Mangeni, Steve M. Taylor, and Andrew A. Obala. "Mosquito Exposure and Malaria Morbidity: A Microlevel Analysis of Household Mosquito Populations and Malaria in a Population-Based Longitudinal Cohort in Western Kenya." Journal of Infectious Diseases 221, no. 7 (October 30, 2019): 1176–84. http://dx.doi.org/10.1093/infdis/jiz561.
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Abstract Background Malaria morbidity is highly overdispersed in the population. Fine-scale differences in mosquito exposure may partially explain this heterogeneity in individual malaria outcomes. Methods In 38 households we explored the effect of household-level mosquito exposure and individual insecticide-treated net (ITN) use on relative risk (RR) of confirmed malaria. We conducted monthly active surveillance (n = 254; 2624 person-months) and weekly mosquito collection (2092 household-days of collection), and used molecular techniques to confirm human blood feeding and exposure to infectious mosquitoes. Results Of 1494 female Anopheles (89.8% Anopheles gambiae sensu lato), 88.3% were fed, 51.9% had a human blood meal, and 9.2% were sporozoite infected. In total, 168 laboratory-confirmed malaria episodes were reported (incidence rate 0.064 episodes per person-month at risk; 95% confidence interval [CI], .055–.074). Malaria risk was directly associated with exposure to sporozoite-infected mosquitoes (RR, 1.24; 95% CI, 1.11–1.38). No direct effect was measured between ITN use and malaria morbidity; however, ITN use did moderate the effect of mosquito exposure on morbidity. Conclusions Malaria risk increases linearly with vector density and feeding success for persons with low ITN use. In contrast, malaria risk among high ITN users is consistently low and insensitive to variation in mosquito exposure.
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Autry, Dena. "FIELD COMPARISON OF AUTOCIDAL GRAVID OVITRAPS AND IN2CARE TRAPS AGAINST AEDES AEGYPTI IN DOWNTOWN SAINT AUGUSTINE, NORTHEASTERN FLORIDA." Journal of the Florida Mosquito Control Association 68, no. 1 (June 10, 2021): 92–96. http://dx.doi.org/10.32473/jfmca.v68i1.129105.
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Mosquito Control programs are utilizing cost-effective long term autocidal gravid traps because they minimize labor needs while targeting the gravid population of container-breeding mosquitoes. This field study compared the efficacy of the In2Care Mosquito Trap and the Centers for Disease Control and Prevention autocidal gravid ovitrap (CDC-AGO). The study consisted of two control and two treatment sites, and each treatment site had either 100 In2Care Mosquito Traps or 100 CDC-AGOs. Aedes aegypti populations in each site were monitored using Biogent (BG) Sentinel 2 mosquito traps and ovitraps. Analysis of pre- and post-treatment data indicated no significant difference in adult mosquito populations detected by BG traps from either the In2Care or CDC-AGO sites. However, the mean number of eggs collected by ovitraps showed significant reduction in both trap type treated areas posttreatment, compared to pre-treatment. Furthermore, the mean number of egg collections from the In2Care mosquito trap treated area was much less than the collection from the CDC-AGO trap treated area post-treatment.
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Webb, Cameron Ewart, Raffaele Catanzariti, and Steven Hodosi. "Response of Mosquitoes Associated with Estuarine Wetlands to Bushfire in Australia." Journal of the American Mosquito Control Association 37, no. 2 (June 1, 2021): 101–5. http://dx.doi.org/10.2987/20-6972.1.
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ABSTRACT The response of mosquitoes to bushfire is poorly understood. During the 2019–20 summer, many regions of Australia were impacted by devastating bushfires. An area of estuarine and brackish-water wetlands alongside the Georges River, Sydney, New South Wales, was burned in January 2020. Mosquito populations within the area were monitored as part of the local authority's mosquito management program, providing a unique opportunity to record the response of key mosquitoes of pest and public health concern to bushfire. Ground pools within a tidally influenced swamp oak forest dominated by Casuarina glauca and associated wetlands dominated by Phragmites australis and Bolboschoenus spp. had been identified as suitable habitat for a range of mosquitoes, including Aedes alternans, Ae. vigilax, and Verrallina funerea. Surveys of immature stages of mosquitoes within recently burned habitats inundated by tides demonstrated that mosquito eggs survived the direct and indirect impacts of fire and immature stages successfully completed development as reflected in concomitant changes in adult mosquito populations following the bushfire. This unique observation has implications for mosquito management following bushfire in Australia and internationally.
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Wang, Sibao, André L. A. Dos-Santos, Wei Huang, Kun Connie Liu, Mohammad Ali Oshaghi, Ge Wei, Peter Agre, and Marcelo Jacobs-Lorena. "Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria." Science 357, no. 6358 (September 28, 2017): 1399–402. http://dx.doi.org/10.1126/science.aan5478.
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The huge burden of malaria in developing countries urgently demands the development of novel approaches to fight this deadly disease. Although engineered symbiotic bacteria have been shown to render mosquitoes resistant to the parasite, the challenge remains to effectively introduce such bacteria into mosquito populations. We describe a Serratia bacterium strain (AS1) isolated from Anopheles ovaries that stably colonizes the mosquito midgut, female ovaries, and male accessory glands and spreads rapidly throughout mosquito populations. Serratia AS1 was genetically engineered for secretion of anti-Plasmodium effector proteins, and the recombinant strains inhibit development of Plasmodium falciparum in mosquitoes.
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Burgess, Colleen, Lis Nelis, and Cassie Huang. "Modeling Zika Vaccination Combined With Vector Interventions in DoD Populations." Military Medicine 186, Supplement_1 (January 1, 2021): 82–90. http://dx.doi.org/10.1093/milmed/usaa340.
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ABSTRACT Introduction Zika virus (ZIKV) is a mild febrile illness generally transmitted via the bite of infected Aedes species mosquitoes, including Aedes aegypti, with the potential to cause neurological complications. Nearly 200 U.S. military installations are located within areas where Aedes mosquitos are found, putting thousands of personnel at risk for infection with ZIKV. This analysis aims to quantify the benefits of interventions, including vaccination, to decrease the risk of ZIKV on U.S. military installations. Methods The authors developed a dynamic transmission model to test the “effectiveness” of vaccination, personal protective measures (PPM), and mosquito control at reducing morbidity within U.S. military populations. ZIKV transmission was modeled as a compartmental susceptible-exposed-infected-recovered model tracking interactions between humans and mosquitos and incorporating seasonality of mosquito populations and the potential for herd immunity. The model included two-dose vaccination as well as symptomatic and asymptomatic infection. The model was calibrated against 2016 public health data in Puerto Rico; sensitivity analyses were performed on model parameters and interventions. Results The greatest reduction in total modeled ZIKV cases resulted from vaccination combined with mosquito control and PPM. All three interventions at their highest estimated level of efficiency reduced ZIKV cases by 99.9% over the baseline case of low-level adherence to PPM. The addition of vaccination had limited additional benefit over effective vector control and PPM since the significant lag to vaccine-induced protection limited effectiveness of vaccination. Conclusions Given the current vaccine, the model predicted that up to 92.8% of Zika cases occurring in deployment settings over a 10-year period could be prevented by adding vaccination to current low-level PPM. Combining vaccination with other interventions can reduce cases further. A location-specific cost-benefit analysis would be a valuable contribution to outbreak control policy as it could evaluate the economic impact of the interventions versus the reduced level of illness and downtime in this setting.
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Mohd Ngesom, Ahmad Mohiddin, Nazni Wasi Ahmad, Han Lim Lee, Asmalia Md Lasim, David Greenhalgh, Mazrura Sahani, Rozita Hod, and Hidayatulfathi Othman. "Evaluating the Potential of Pyriproxyfen Dissemination using Mosquito Home System against Aedes albopictus at a Dengue Hotspot Area." Sains Malaysiana 50, no. 8 (August 31, 2021): 2379–93. http://dx.doi.org/10.17576/jsm-2021-5008-20.
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Aedes mosquitoes were found to lay their eggs in the cryptic breeding sites. Eliminating cryptic and open breeding sites is essential in reducing dengue virus transmission. However, it is often challenging for health officers to assess these breeding sites which are usually missed during larval surveillance. The autodissemination approach may produce a better outcome by manipulating female mosquitoes to disperse insecticide to other Aedes spp. mosquito habitats. Thus, the present study aims to evaluate the effectiveness of the pyriproxyfen autodissemination technique using Mosquito Home System against the population of mosquitoes. This study was conducted in Bandar Baru Bangi, Selangor, Malaysia. The Mosquito Home System was deployed to control Aedes spp. populations at treatment sites using before-after-control-impact (BACI) design. The presence of pyriproxyfen distribution was confirmed using the WHO larval bioassay which resulted in 10-35% larvae mortalities. Autodissemination of pyriproxyfen significantly reduced the population size of mosquito eggs (p<0.05), larvae (p<0.05), and ovitrap index (p<0.05) at the treatment areas compared to the control areas. Moreover, rainfall was correlated positively against ovitrap index (r = 0.247), larvae (r = 0.420), and eggs (r = 0.422). The study provides promising results for controlling Aedes spp. populations and also highlights the potentials of this technique as an alternative in vector control programmes. However, further studies on larger scale field trials are warranted.
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Li, Jia. "Heterogeneity in modelling of mosquito populations with transgenic mosquitoes." Journal of Difference Equations and Applications 11, no. 4-5 (April 2005): 443–57. http://dx.doi.org/10.1080/10236190412331335490.
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Duguma, Dagne, Michael W. Hall, Chelsea T. Smartt, Mustapha Debboun, and Josh D. Neufeld. "Microbiota variations in Culex nigripalpus disease vector mosquito of West Nile virus and Saint Louis Encephalitis from different geographic origins." PeerJ 6 (January 9, 2019): e6168. http://dx.doi.org/10.7717/peerj.6168.
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Although mosquito microbiota are known to influence reproduction, nutrition, disease transmission, and pesticide resistance, the relationship between host-associated microbial community composition and geographical location is poorly understood. To begin addressing this knowledge gap, we characterized microbiota associated with adult females of Culex nigripalpus mosquito vectors of Saint Louis Encephalitis and West Nile viruses sampled from three locations in Florida (Vero Beach, Palmetto Inland, and Palmetto Coast). High-throughput sequencing of PCR-amplified 16S rRNA genes demonstrated significant differences among microbial communities of mosquitoes sampled from the three locations. Mosquitoes from Vero Beach (east coast Florida) were dominated by uncultivated Asaia sp. (Alphaproteobacteria), whereas microbiota associated with mosquitoes collected from two mosquito populations at Palmetto (west coast Florida) sites were dominated by uncultured Spironema culicis (Spirochaetes), Salinisphaera hydrothermalis (Gammaproteobacteria), Spiroplasma (Mollicutes), uncultured Enterobacteriaceae, Candidatus Megaira (Alphaproteobacteria; Rickettsiae), and Zymobacter (Gammaproteobacteria). The variation in taxonomic profiles of Cx. nigripalpus gut microbial communities, especially with respect to dominating taxa, is a potentially critical factor in understanding disease transmission and mosquito susceptibility to insecticides among different mosquito populations.
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Leonard, Mark P., and Jonathan D. Oliver. "Mosquito Guttersnipe: A New Sampling Tool for Roof Gutters, Tree Holes, and Other Elevated Mosquito Habitats." Journal of the American Mosquito Control Association 37, no. 2 (June 1, 2021): 109–12. http://dx.doi.org/10.2987/20-6988.1.
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ABSTRACT Mosquitoes pose health risks to human populations by serving as vectors of diseases. Mosquito control organizations are responsible for inspecting and controlling vector populations to reduce the risk of infection of these diseases. Current sampling methods are effective for numerous types of mosquito habitat, but not conducive for sampling small overhead habitat such as roof gutters or tree holes. We have developed and tested a tool called the Mosquito GutterSnipe to sample these overhead habitats. Volumetric and larval capacity testing of the tool prototype demonstrated comparable sampling integrity to standard mosquito dipping methods. The GutterSnipe can be employed as a reliable way to sample previously overlooked mosquito habitat. Its current model is cost effective and easy to produce for mosquito control organizations and easy to use for inspectors.
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Graves, P. M., T. R. Burkot, R. Carter, J. A. Cattani, M. Lagog, J. Parker, B. J. Brabin, F. D. Gibson, D. J. Bradley, and M. P. Alpers. "Measurement of malarial infectivity of human populations to mosquitoes in the Madang area, Papua New Guinea." Parasitology 96, no. 2 (April 1988): 251–63. http://dx.doi.org/10.1017/s003118200005825x.
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SummaryThe proportion of blood meals taken on humans which are infectious to mosquitoes in the Madang area, Papua New Guinea was estimated by two methods. In the first, laboratory rearedAnopheles farautiwere fed on individuals of all ages at village surveys. The results showed that 3·8% of people were infectious and that the mean percentage of mosquitoes which became infected by feeding on these people was 37·9%. From the average proportion of mosquitoes infected, the probability that a mosquito feeding on a human would pick up infection was 0·013±0·005. In the second approach mosquitoes were fed on identifiedPlasmodium falciparum, P. vivaxandP. malariaegametocyte carriers. The results indicated that 46% of gametocyte carriers were infectious and that the mean probability of a mosquito becoming infected after feeding on a gametocyte carrier was 0·151±0·029. Gametocyte prevalence rates in all ages measured over 18 months in three villages averaged 3·3%P. falciparum, 4·0%P. vivaxand 0·7%P. malariae, totalling 8·0±0·7%. Combining gametocyte prevalence rates with the probability of a mosquito becoming infected from a gametocyte carrier, the probability of a mosquito becoming infected following a blood meal on a member of the human population was estimated to be 0·012±0·003.
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Resmawan, Resmawan, Paian Sianturi, and Endar Hasafah Nugrahani. "The Analysis of SEIRS-SEI Epidemic Models on Malaria with Regard to Human Recovery Rate." Aceh International Journal of Science and Technology 6, no. 3 (December 31, 2017): 132–40. http://dx.doi.org/10.13170/aijst.6.3.9303.
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This article discusses SEIRS-SEI epidemic models on malaria with regard to human recovery rate. SEIRS-SEI in this model is an abbreviation of the population class used in the model, ie Susceptible, Exposed, Infected, and Recovered populations in humans and Susceptible, Exposed, and Infected populations in mosquito. These epidemic models belong to mathematical models which clarify a phenomenon of epidemic transmission of malaria by observing the human recovery rate after being infected and susceptible. Human population falls into four classes, namely susceptible humans, exposed humans, infected humans, and recovered humans. Meanwhile, mosquito population serving as vectors of the disease is divided into three classes, including susceptible mosquitoes, exposed mosquitoes, and infected mosquitoes. Such models are termed SEIRS-SEI epidemic models. Analytical discussion covers model formation, existence and stability of equilibrium points, as well as numerical simulation to find out the influence of human recovery rate on population dynamics of both species. The results show that the fixed point without disease ( ) is stable in condition and unstable in condition . The simulation results show that the given treatment has an influence on the dynamics of the human population and mosquitoes. If the human recovery rate from the infected state becomes susceptible to increased, then the number of infected populations of both species will decrease. As a result, the disease will not spread and within a certain time will disappear from the population.
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Li, Yijie, Zhiming Guo, and Yanyuan Xing. "Modeling Wolbachia Diffusion in Mosquito Populations by Discrete Competition Model." Discrete Dynamics in Nature and Society 2020 (February 27, 2020): 1–11. http://dx.doi.org/10.1155/2020/8987490.
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Dengue fever is caused by dengue virus and transmitted by Aedes mosquitoes. A promising avenue to control this disease is to infect the wild Aedes population with the bacterium Wolbachia driven by cytoplasmic incompatibility (CI). To study the invasion of Wolbachia into wild mosquito population, we formulate a discrete competition model and analyze the competition between released mosquitoes and wild mosquitoes. We show the global asymptotic properties of the trivial equilibrium, boundary equilibrium, and positive equilibrium and give the conditions for the successful invasion of Wolbachia. Finally, we verify our findings by numerical simulations.
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King, Robin A., Rebecca Heinig, Patrick Linn, and Keira J. Lucas. "The Impact of Hurricane Irma on Our Community and the Collier Mosquito Control District's Mission." Journal of the American Mosquito Control Association 36, no. 2s (June 1, 2020): 11–14. http://dx.doi.org/10.2987/19-6876.1.
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ABSTRACT The Collier Mosquito Control District, located in southwest Florida, is uniquely positioned in a subtropical environment between the Gulf of Mexico and Everglades National Park. The District's mission is focused on the control of disease vector and nuisance mosquitoes in Collier County, which is accomplished through integrated mosquito management. Hurricane Irma made landfall in the county on September 10, 2017, leaving in its wake tremendous property and infrastructure damage, and it also disrupted communications and airport operations. These factors greatly affected the District's operations and its ability to meet its mission. In addition, the lengthy loss of electrical power forced most residents outdoors, increasing their exposure to mosquitoes. From challenges in completing poststorm treatments to outdated policies that caught us off-guard, the event prompted a new hurricane policy and plan to ensure improved preparedness for the next natural disaster. The poststorm environment also provided a rich foundation for research into mosquito populations after tropical disturbances of this scale. Here we report the impact on the District's aerial mosquito control operations, changes to internal policies, and mosquito population abundance following Hurricane Irma.
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Lumpkin, Will P., Kincade R. Stirek, and Lee A. Dyer. "Macrophyte Diversity and Complexity Reduce Larval Mosquito Abundance." Journal of Medical Entomology 57, no. 4 (February 1, 2020): 1041–48. http://dx.doi.org/10.1093/jme/tjaa012.
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Abstract The role of aquatic arthropod diversity and community interactions of larval mosquitoes are important for understanding mosquito population dynamics. We tested the effects of aquatic macrophyte diversity and habitat structural complexity in shaping the predator and competitor invertebrate communities associated with mosquito larvae. Experimental mesocosms were planted with live aquatic macrophytes and allowed to be naturally colonized by local invertebrates. Results indicated a positive effect of macrophyte diversity on competitor diversity and a negative effect on predator diversity. In turn, predator diversity negatively impacted mosquito abundance through a direct effect, while competitor diversity showed an indirect negative effect on mosquito larval abundance through its positive effect on predator diversity. The enhancement of aquatic macrophyte diversity and structural complexity has practical applications for the reduction of mosquito populations in managed systems where complete source elimination is not possible.
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Kosal, Erica, and Beverly I. Anaele. "Testing Mosquitoes for Student Inquiry." American Biology Teacher 83, no. 3 (March 1, 2021): 180–84. http://dx.doi.org/10.1525/abt.2021.83.3.180.
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Because mosquitoes are a public health concern, several chemical insect repellents have been created and used for many years. While some of these products, such as DEET and permethrin, are effective at controlling mosquito populations, their excessive use may lead to animal, human, and environmental harm if applied improperly. Understanding the life cycles of mosquitoes, their feeding preferences, and their responses to natural plant extracts could enable scientists to develop more environmentally safe but still effective insect repellents. Various types of plant extracts (e.g., American beautyberry, Callicarpa americana) hold promise. In order to study such plant–mosquito interactions, we had to establish basic husbandry practices for successfully rearing and maintaining mosquito populations in the lab. We discuss the protocols we have used for housing mosquitoes and creating plant extracts and offer suggestions for how students can use both for inquiry.
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Lundkvist, E., J. Landin, M. Jackson, and C. Svensson. "Diving beetles (Dytiscidae) as predators of mosquito larvae (Culicidae) in field experiments and in laboratory tests of prey preference." Bulletin of Entomological Research 93, no. 3 (June 2003): 219–26. http://dx.doi.org/10.1079/ber2003237.
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AbstractField experiments were performed in artificial ponds to evaluate how the density of predatory diving beetles (Dytiscidae) would affect the population levels of mosquito larvae (Culicidae). Mosquitoes colonizing the ponds were predominantly species of the genus Culex. In 2000, most of the dytiscids colonizing the ponds were small (Hydroporus spp.), and these predators had no impact on the size of larval mosquito populations, not even in ponds with added dytiscids. In 2001, larger beetles (Ilybius, Rhantus, and Agabus spp.) were more common, and there were significantly fewer mosquito larvae in ponds with the highest numbers of dytiscids. There was a negative correlation between numbers of diving beetles in the ponds and the mean body length of mosquito larvae. In neither year could dytiscid densities be maintained above a certain level owing to emigration. In laboratory tests, there were marked differences between three common dytiscid species in regard to preferences for Daphnia and Culex species as prey: Colymbetes paykulli Erichson chose mosquito larvae more often, whereas both Ilybius ater (De Geer) and I. fuliginosus (Fabricius) preferred Daphnia spp. All of the tested dytiscids consumed large numbers of prey. Since some dytiscid species can efficiently decrease populations of mosquito larvae, they are probably important in the natural control of these dipterans.
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Gloria-Soria, A., P. M. Armstrong, J. R. Powell, and P. E. Turner. "Infection rate of Aedes aegypti mosquitoes with dengue virus depends on the interaction between temperature and mosquito genotype." Proceedings of the Royal Society B: Biological Sciences 284, no. 1864 (October 4, 2017): 20171506. http://dx.doi.org/10.1098/rspb.2017.1506.
Full textAbstract:
Dengue fever is the most prevalent arthropod-transmitted viral disease worldwide, with endemic transmission restricted to tropical and subtropical regions of different temperature profiles. Temperature is epidemiologically relevant because it affects dengue infection rates in Aedes aegypti mosquitoes, the major vector of the dengue virus (DENV). Aedes aegypti populations are also known to vary in competence for different DENV genotypes. We assessed the effects of mosquito and virus genotype on DENV infection in the context of temperature by challenging Ae. aegypti from two locations in Vietnam, which differ in temperature regimes, with two isolates of DENV-2 collected from the same two localities, followed by incubation at 25, 27 or 32°C for 10 days. Genotyping of the mosquito populations and virus isolates confirmed that each group was genetically distinct. Extrinsic incubation temperature (EIT) and DENV-2 genotype had a direct effect on the infection rate, consistent with previous studies. However, our results show that the EIT impacts the infection rate differently in each mosquito population, indicating a genotype by environment interaction. These results suggest that the magnitude of DENV epidemics may not only depend on the virus and mosquito genotypes present, but also on how they interact with local temperature. This information should be considered when estimating vector competence of local and introduced mosquito populations during disease risk evaluation.
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Kofidou, Maria, Michael de Courcy Williams, Andreas Nearchou, Stavroula Veletza, Alexandra Gemitzi, and Ioannis Karakasiliotis. "Applying Remotely Sensed Environmental Information to Model Mosquito Populations." Sustainability 13, no. 14 (July 8, 2021): 7655. http://dx.doi.org/10.3390/su13147655.
Full textAbstract:
Vector borne diseases have been related to various environmental parameters and environmental changes like climate change, which impact their propagation in time and space. Remote sensing data have been used widely for monitoring environmental conditions and changes. We hypothesized that changes in various environmental parameters may be reflected in changes in mosquito population size, thus impacting the temporal and spatial patterns of vector diseases. The aim of this study is to analyze the effect of environmental variables on mosquito populations using the remotely sensed Normalized Difference Vegetation Index (NDVI) and Land Surface Temperature (LST) obtained from Landsat 8, along with other factors, such as altitude and water covered areas surrounding the examined locations. Therefore, a Multilayer Perceptron (MLP) Artificial Neural Network (ANN) model was developed and tested for its ability to predict mosquito populations. The model was applied in NE Greece using mosquito population data from 17 locations where mosquito traps were placed from June to October 2019. All performance metrics indicated a high predictive ability of the model. LST was proved to be the factor with the highest relative importance in the prediction of mosquito populations, whereas the developed model can predict mosquito populations 13 days ahead to allow a substantial window for appropriate control measures.
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Agarwal, Manju, and Archana S. Bhadauria. "A stage structured model of malaria transmission and efficacy of mosquito larvicides in its control." International Journal of Modeling, Simulation, and Scientific Computing 05, no. 04 (September 29, 2014): 1450023. http://dx.doi.org/10.1142/s1793962314500238.
Full textAbstract:
In this paper, we analyze a stage structured mathematical model for the transmission of malaria and its control by killing mosquitoes in larvae (immature) stage. Both the Mosquito and human populations are divided into susceptible and infective class. Susceptible class of mosquito population is further divided into mature and immature. The model is analyzed by using stability theory of nonlinear ordinary differential equations. Basic reproduction ratio is derived which is found to be the decreasing function of maturation delay and larvicidal activity. In addition, it is observed that biting rate of mosquito, transmission efficiency of parasitic infection from infective human to mosquito and critical value of maturation delay are the key parameters determining the stability switch in the system. Numerical simulation is also carried out to confirm the analytical results obtained in the paper.
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Yen, Pei-Shi, and Anna-Bella Failloux. "A Review: Wolbachia-Based Population Replacement for Mosquito Control Shares Common Points with Genetically Modified Control Approaches." Pathogens 9, no. 5 (May 22, 2020): 404. http://dx.doi.org/10.3390/pathogens9050404.
Full textAbstract:
The growing expansion of mosquito vectors has made mosquito-borne arboviral diseases a global threat to public health, and the lack of licensed vaccines and treatments highlight the urgent need for efficient mosquito vector control. Compared to genetically modified control strategies, the intracellular bacterium Wolbachia, endowing a pathogen-blocking phenotype, is considered an environmentally friendly strategy to replace the target population for controlling arboviral diseases. However, the incomplete knowledge regarding the pathogen-blocking mechanism weakens the reliability of a Wolbachia-based population replacement strategy. Wolbachia infections are also vulnerable to environmental factors, temperature, and host diet, affecting their densities in mosquitoes and thus the virus-blocking phenotype. Here, we review the properties of the Wolbachia strategy as an approach to control mosquito populations in comparison with genetically modified control methods. Both strategies tend to limit arbovirus infections but increase the risk of selecting arbovirus escape mutants, rendering these strategies less reliable.
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Deichstetter, Peggy. "The Effect of Climate Change on Mosquito-Borne Diseases." American Biology Teacher 79, no. 3 (March 1, 2017): 169–73. http://dx.doi.org/10.1525/abt.2017.79.3.169.
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Global climate change will affect all living things on this planet. For many species, the change in their environment may mean extinction. However, there is one organism, the mosquito, that may benefit from changes in the climate. This paper addresses the possible effects of climate change on mosquitoes, including longer breeding seasons and increased hatch rates of populations. The enlarged population will cause mosquitoes to seek more territory, and the warmer climate will in turn make more territory available. If mosquitoes increase in population, there may be an amplification of mosquito-borne diseases such as malaria, yellow fever, Chikungunya virus, St. Louis encephalitis, West Nile virus, and the Zika virus. This trend of increased range because of climate change has already been observed in dengue fever. This information can be used as an engaging segue into teaching students about climate change and vector-borne disease.
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González Jiménez, Mario, Simon A. Babayan, Pegah Khazaeli, Margaret Doyle, Finlay Walton, Elliott Reedy, Thomas Glew, et al. "Prediction of mosquito species and population age structure using mid-infrared spectroscopy and supervised machine learning." Wellcome Open Research 4 (May 1, 2019): 76. http://dx.doi.org/10.12688/wellcomeopenres.15201.1.
Full textAbstract:
Despite the global efforts made in the fight against malaria, the disease is resurging. One of the main causes is the resistance that Anopheles mosquitoes, vectors of the disease, have developed to insecticides. Anopheles must survive for at least 10 days to possibly transmit malaria. Therefore, to evaluate and improve malaria vector control interventions, it is imperative to monitor and accurately estimate the age distribution of mosquito populations as well as their population sizes. Here, we demonstrate a machine-learning based approach that uses mid-infrared spectra of mosquitoes to characterise simultaneously both age and species identity of females of the African malaria vector species Anopheles gambiae and An. arabiensis. mid-infrared spectroscopy-based prediction of mosquito age structures was statistically indistinguishable from true modelled distributions. The accuracy of classifying mosquitoes by species was 82.6%. The method has a negligible cost per mosquito, does not require highly trained personnel, is rapid, and so can be easily applied in both laboratory and field settings. Our results indicate this method is a promising alternative to current mosquito species and age-grading approaches, with further improvements to accuracy and expansion for use with other mosquito vectors possible through collection of larger mid-infrared spectroscopy data sets.
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González Jiménez, Mario, Simon A. Babayan, Pegah Khazaeli, Margaret Doyle, Finlay Walton, Elliott Reedy, Thomas Glew, et al. "Prediction of mosquito species and population age structure using mid-infrared spectroscopy and supervised machine learning." Wellcome Open Research 4 (August 7, 2019): 76. http://dx.doi.org/10.12688/wellcomeopenres.15201.2.
Full textAbstract:
Despite the global efforts made in the fight against malaria, the disease is resurging. One of the main causes is the resistance that Anopheles mosquitoes, vectors of the disease, have developed to insecticides. Anopheles must survive for at least 10 days to possibly transmit malaria. Therefore, to evaluate and improve malaria vector control interventions, it is imperative to monitor and accurately estimate the age distribution of mosquito populations as well as their population sizes. Here, we demonstrate a machine-learning based approach that uses mid-infrared spectra of mosquitoes to characterise simultaneously both age and species identity of females of the African malaria vector species Anopheles gambiae and An. arabiensis, using laboratory colonies. Mid-infrared spectroscopy-based prediction of mosquito age structures was statistically indistinguishable from true modelled distributions. The accuracy of classifying mosquitoes by species was 82.6%. The method has a negligible cost per mosquito, does not require highly trained personnel, is rapid, and so can be easily applied in both laboratory and field settings. Our results indicate this method is a promising alternative to current mosquito species and age-grading approaches, with further improvements to accuracy and expansion for use with wild mosquito vectors possible through collection of larger mid-infrared spectroscopy data sets.
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González Jiménez, Mario, Simon A. Babayan, Pegah Khazaeli, Margaret Doyle, Finlay Walton, Elliott Reedy, Thomas Glew, et al. "Prediction of mosquito species and population age structure using mid-infrared spectroscopy and supervised machine learning." Wellcome Open Research 4 (September 16, 2019): 76. http://dx.doi.org/10.12688/wellcomeopenres.15201.3.
Full textAbstract:
Despite the global efforts made in the fight against malaria, the disease is resurging. One of the main causes is the resistance that Anopheles mosquitoes, vectors of the disease, have developed to insecticides. Anopheles must survive for at least 10 days to possibly transmit malaria. Therefore, to evaluate and improve malaria vector control interventions, it is imperative to monitor and accurately estimate the age distribution of mosquito populations as well as their population sizes. Here, we demonstrate a machine-learning based approach that uses mid-infrared spectra of mosquitoes to characterise simultaneously both age and species identity of females of the African malaria vector species Anopheles gambiae and An. arabiensis, using laboratory colonies. Mid-infrared spectroscopy-based prediction of mosquito age structures was statistically indistinguishable from true modelled distributions. The accuracy of classifying mosquitoes by species was 82.6%. The method has a negligible cost per mosquito, does not require highly trained personnel, is rapid, and so can be easily applied in both laboratory and field settings. Our results indicate this method is a promising alternative to current mosquito species and age-grading approaches, with further improvements to accuracy and expansion for use with wild mosquito vectors possible through collection of larger mid-infrared spectroscopy data sets.
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Burt, Austin. "Heritable strategies for controlling insect vectors of disease." Philosophical Transactions of the Royal Society B: Biological Sciences 369, no. 1645 (June 19, 2014): 20130432. http://dx.doi.org/10.1098/rstb.2013.0432.
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Mosquito-borne diseases are causing a substantial burden of mortality, morbidity and economic loss in many parts of the world, despite current control efforts, and new complementary approaches to controlling these diseases are needed. One promising class of new interventions under development involves the heritable modification of the mosquito by insertion of novel genes into the nucleus or of Wolbachia endosymbionts into the cytoplasm. Once released into a target population, these modifications can act to reduce one or more components of the mosquito population's vectorial capacity (e.g. the number of female mosquitoes, their longevity or their ability to support development and transmission of the pathogen). Some of the modifications under development are designed to be self-limiting, in that they will tend to disappear over time in the absence of recurrent releases (and hence are similar to the sterile insect technique, SIT), whereas other modifications are designed to be self-sustaining, spreading through populations even after releases stop (and hence are similar to traditional biological control). Several successful field trials have now been performed with Aedes mosquitoes, and such trials are helping to define the appropriate developmental pathway for this new class of intervention.
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Park, Seo Hye, Hojong Jun, Seong Kyu Ahn, Jinyoung Lee, Sung-Lim Yu, Sung Keun Lee, Jung-Mi Kang, et al. "Monitoring Insecticide Resistance and Target Site Mutations of L1014 Kdr And G119 Ace Alleles in Five Mosquito Populations in Korea." Korean Journal of Parasitology 58, no. 5 (October 22, 2020): 543–50. http://dx.doi.org/10.3347/kjp.2020.58.5.543.
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Mosquitoes are globally distributed and important vectors for the transmission of many human diseases. Mosquito control is a difficult task and the cost of preventing mosquito-borne diseases is much lower than that for curing the associated diseases. Thus, chemical control remains the most effective tool for mosquito. Due to the long-term intensive use of insecticides to control mosquito vectors, resistance to most chemical insecticides has been reported. This study aimed to investigate the relationship between insecticide resistance and target site mutation of L1014 kdr and G119 ace alleles in 5 species/species group of mosquitoes (Aedes vexans, Ae. albopictus, Anopheles spp., Culex pipiens complex, and Cx. tritaeniorhynchus) obtained from 6 collection sites. For Anopheles spp., the proportion of mosquitoes with mutated alleles in L1014 was 88.4%, homozygous resistant genotypes were observed in 46.7%, and heterozygous resistant genotypes were observed in 41.8%. For the Cx. pipiens complex and Cx. tritaeniorhynchus species, homozygous resistant genotypes were found in 25.9% and 9.8%, respectively. However, target site mutation of L1014 in the Ae. vexans nipponii and Ae. albopictus species was not observed. Anopheles spp., Cx. pipiens complex, and Cx. tritaeniorhynchus mosquitoes were resistant to deltamethrin and chlorpyriphos, whereas Ae. vexans nipponii and Ae. albopictus were clearly susceptible. We also found a correlation between the resistance phenotype and the presence of the L1014 kdr and G119 ace mutations only in the Anopheles spp. population. In this study, we suggest that insecticide resistance poses a growing threat and resistance management must be integrated into all mosquito control programs.
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Unlu, Isik, Ilia Rochlin, Devi S. Suman, Yi Wang, Kshitij Chandel, and Randy Gaugler. "Large-Scale Operational Pyriproxyfen Autodissemination Deployment to Suppress the Immature Asian Tiger Mosquito (Diptera: Culicidae) Populations." Journal of Medical Entomology 57, no. 4 (February 1, 2020): 1120–30. http://dx.doi.org/10.1093/jme/tjaa011.
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Abstract Effective suppression of container-inhabiting Asian Tiger [Aedes albopictus (Skuse)] (Diptera: Culicidae) and yellow fever [Aedes aegypti (L.)] (Diptera: Culicidae) mosquitoes presents one of the most intractable problems for modern mosquito control. Traditional tools often fail to control populations of these mosquito species, and are prohibitively expensive or have negative environmental impacts. Novel approaches and tools are urgently needed for integrated container-inhabiting mosquito management programs. One of the most promising techniques is autodissemination. We present the results of a long-term large-scale study conducted in a temperate urbanized environment representing typical Ae. albopictus habitats. Three treatment sites with autodissemination stations and three nearby reference sites were monitored for eggs, immature, and adult mosquitoes over a period of 3 yr from 2014 to 2016. Elevated larval and pupal mortality of 12–19% on average was the most notable outcome in sentinel cups of the treatment sites. The number of eggs in the treatment sites was significantly reduced in 2014, but not in 2015 or 2016. Adult populations remained similar in treatment and reference sites throughout the study. The impact of autodissemination on mosquito populations was lower than reported by previous investigations. Technical and logistical problems associated with wider coverage and working in multiple urban neighborhoods contributed to reduced efficacy. Incorporating autodissemination with routine mosquito control operations and commercializing this methodology for general public use will require further research on combining this tool with other novel or conventional technologies.
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Moreno-Gómez, Mara, Rubén Bueno-Marí, and Miguel A. Miranda. "A Three-Pronged Approach to Studying Sublethal Insecticide Doses: Characterising Mosquito Fitness, Mosquito Biting Behaviour, and Human/Environmental Health Risks." Insects 12, no. 6 (June 11, 2021): 546. http://dx.doi.org/10.3390/insects12060546.
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Worldwide, pyrethroids are one of the most widely used insecticide classes. In addition to serving as personal protection products, they are also a key line of defence in integrated vector management programmes. Many studies have assessed the effects of sublethal pyrethroid doses on mosquito fitness and behaviour. However, much remains unknown about the biological, physiological, demographic, and behavioural effects on individual mosquitoes or mosquito populations when exposure occurs via spatial treatments. Here, females and males of two laboratory-reared mosquito species, Culex pipiens and Aedes albopictus, were exposed to five different treatments: three doses of the pyrethroid prallethrin, as well as an untreated and a negative control. The effects of each treatment on mosquito species, sex, adult mortality, fertility, F1 population size, and biting behaviour were also evaluated. To compare knockdown and mortality among treatments, Mantel–Cox log-rank tests were used. The results showed that sublethal doses reduced mosquito survival, influencing population size in the next generation. They also provided 100% protection to human hosts and presented relatively low risks to human and environmental health. These findings emphasise the need for additional studies that assess the benefits of using sublethal doses as part of mosquito management strategies.
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Ketkar, Harshada, Daniella Herman, and Penghua Wang. "Genetic Determinants of the Re-Emergence of Arboviral Diseases." Viruses 11, no. 2 (February 12, 2019): 150. http://dx.doi.org/10.3390/v11020150.
Full textAbstract:
Mosquito-borne diseases constitute a large portion of infectious diseases, causing more than 700,000 deaths annually. Mosquito-transmitted viruses, such as yellow fever, dengue, West Nile, chikungunya, and Zika viruses, have re-emerged recently and remain a public health threat worldwide. Global climate change, rapid urbanization, burgeoning international travel, expansion of mosquito populations, vector competence, and host and viral genetics may all together contribute to the re-emergence of arboviruses. In this brief review, we summarize the host and viral genetic determinants that may enhance infectivity in the host, viral fitness in mosquitoes and viral transmission by mosquitoes.
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Ryan, Peter A., Andrew P. Turley, Geoff Wilson, Tim P. Hurst, Kate Retzki, Jack Brown-Kenyon, Lauren Hodgson, et al. "Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia." Gates Open Research 3 (September 26, 2019): 1547. http://dx.doi.org/10.12688/gatesopenres.13061.1.
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Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown in laboratory studies to reduce transmission of a range of viruses including dengue, Zika, chikungunya, yellow fever, and Mayaro viruses that cause human disease. Here we report the entomological and epidemiological outcomes of staged deployment of Wolbachia across nearly all significant dengue transmission risk areas in Australia. Methods: The wMel strain of Wolbachia was backcrossed into the local Aedes aegypti genotype (Cairns and Townsville backgrounds) and mosquitoes were released in the field by staff or via community assisted methods. Mosquito monitoring was undertaken and mosquitoes were screened for the presence of Wolbachia. Dengue case notifications were used to track dengue incidence in each location before and after releases. Results: Empirical analyses of the Wolbachia mosquito releases, including data on the density, frequency and duration of Wolbachia mosquito releases, indicate that Wolbachia can be readily established in local mosquito populations, using a variety of deployment options and over short release durations (mean release period 11 weeks, range 2-22 weeks). Importantly, Wolbachia frequencies have remained stable in mosquito populations since releases for up to 8 years. Analysis of dengue case notifications data demonstrates near-elimination of local dengue transmission for the past five years in locations where Wolbachia has been established. The regression model estimate of Wolbachia intervention effect from interrupted time series analyses of case notifications data prior to and after releases, indicated a 96% reduction in dengue incidence in Wolbachia treated populations (95% confidence interval: 84 – 99%). Conclusion: Deployment of the wMel strain of Wolbachia into local Ae. aegypti populations across the Australian regional cities of Cairns and most smaller regional communities with a past history of dengue has resulted in the reduction of local dengue transmission across all deployment areas.
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Ryan, Peter A., Andrew P. Turley, Geoff Wilson, Tim P. Hurst, Kate Retzki, Jack Brown-Kenyon, Lauren Hodgson, et al. "Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia." Gates Open Research 3 (April 8, 2020): 1547. http://dx.doi.org/10.12688/gatesopenres.13061.2.
Full textAbstract:
Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown in laboratory studies to reduce transmission of a range of viruses including dengue, Zika, chikungunya, yellow fever, and Mayaro viruses that cause human disease. Here we report the entomological and epidemiological outcomes of staged deployment of Wolbachia across nearly all significant dengue transmission risk areas in Australia. Methods: The wMel strain of Wolbachia was backcrossed into the local Aedes aegypti genotype (Cairns and Townsville backgrounds) and mosquitoes were released in the field by staff or via community assisted methods. Mosquito monitoring was undertaken and mosquitoes were screened for the presence of Wolbachia. Dengue case notifications were used to track dengue incidence in each location before and after releases. Results: Empirical analyses of the Wolbachia mosquito releases, including data on the density, frequency and duration of Wolbachia mosquito releases, indicate that Wolbachia can be readily established in local mosquito populations, using a variety of deployment options and over short release durations (mean release period 11 weeks, range 2-22 weeks). Importantly, Wolbachia frequencies have remained stable in mosquito populations since releases for up to 8 years. Analysis of dengue case notifications data demonstrates near-elimination of local dengue transmission for the past five years in locations where Wolbachia has been established. The regression model estimate of Wolbachia intervention effect from interrupted time series analyses of case notifications data prior to and after releases, indicated a 96% reduction in dengue incidence in Wolbachia treated populations (95% confidence interval: 84 – 99%). Conclusion: Deployment of the wMel strain of Wolbachia into local Ae. aegypti populations across the Australian regional cities of Cairns and most smaller regional communities with a past history of dengue has resulted in the reduction of local dengue transmission across all deployment areas.
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Peffers, Caitlin S., Laura W. Pomeroy, and Megan E. Meuti. "Critical Photoperiod and Its Potential to Predict Mosquito Distributions and Control Medically Important Pests." Journal of Medical Entomology 58, no. 4 (April 9, 2021): 1610–18. http://dx.doi.org/10.1093/jme/tjab049.
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Abstract Diapause, a period of arrested development that allows mosquitoes to survive inhospitable conditions, is triggered by short daylengths in temperate mosquitoes. Different populations of mosquitoes initiate diapause in response to a specific photoperiod, or daylength, resulting in population-specific differences in annual cycles of abundance. The photoperiod that causes approximately 50% of a population to initiate diapause is known as the critical photoperiod (CPP). The autumn daylength corresponding to the CPP in the field likely marks the day beyond which the photoperiods would trigger and maintain 50% or more diapause incidence in a population, although temperature, diet, and other factors can impact diapause initiation. In the Northern Hemisphere, northern populations of mosquitoes experience lower temperatures earlier in the year and must be triggered into diapause by longer daylengths than southern populations. CPP is genetically based, but also adapts over time responding to the population’s environment. Therefore, CPP has been shown to lengthen with increasing latitude and altitude. While the positive correlation between CPP and latitude/altitude has been established in a few mosquito species, including Aedes albopictus (Skuse, Diptera: Culicidae), Aedes triseriatus, Aedes sierrensis, and Wyeomyia smithii (Coquillett, Diptera: Culicidae), we do not know when most other species initiate their seasonal responses. As several of these species transmit important diseases, characterizing the CPP of arthropod vectors could improve existing control by ensuring that surveillance efforts align with the vector’s seasonally active period. Additionally, better understanding when mosquitoes and other vectors initiate diapause can reduce the frequency of chemical applications, thereby ameliorating the negative impacts to nontarget insects.
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Allman, Megan J., Johanna E. Fraser, Scott A. Ritchie, D. Albert Joubert, Cameron P. Simmons, and Heather A. Flores. "Wolbachia’s Deleterious Impact on Aedes aegypti Egg Development: The Potential Role of Nutritional Parasitism." Insects 11, no. 11 (October 27, 2020): 735. http://dx.doi.org/10.3390/insects11110735.
Full textAbstract:
The artificial introduction of the endosymbiotic bacterium, Wolbachia pipientis, into Aedes (Ae.) aegypti mosquitoes reduces the ability of mosquitoes to transmit human pathogenic viruses and is now being developed as a biocontrol tool. Successful introgression of Wolbachia-carrying Ae. aegypti into native mosquito populations at field sites in Australia, Indonesia and Malaysia has been associated with reduced disease prevalence in the treated community. In separate field programs, Wolbachia is also being used as a mosquito population suppression tool, where the release of male only Wolbachia-infected Ae. aegypti prevents the native mosquito population from producing viable eggs, subsequently suppressing the wild population. While these technologies show great promise, they require mass rearing of mosquitoes for implementation on a scale that has not previously been done. In addition, Wolbachia induces some negative fitness effects on Ae. aegypti. While these fitness effects differ depending on the Wolbachia strain present, one of the most consistent and significant impacts is the shortened longevity and viability of eggs. This review examines the body of evidence behind Wolbachia’s negative effect on eggs, assesses nutritional parasitism as a key cause and considers how these impacts could be overcome to achieve efficient large-scale rearing of these mosquitoes.
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Field, Eleanor N., Ryan E. Tokarz, and Ryan C. Smith. "Satellite Imaging and Long-Term Mosquito Surveillance Implicate the Influence of Rapid Urbanization on Culex Vector Populations." Insects 10, no. 9 (August 24, 2019): 269. http://dx.doi.org/10.3390/insects10090269.
Full textAbstract:
The ecology and environmental conditions of a habitat have profound influences on mosquito population abundance. As a result, mosquito species vary in their associations with particular habitat types, yet long-term studies showing how mosquito populations shift in a changing ecological landscape are lacking. To better understand how land use changes influence mosquito populations, we examined mosquito surveillance data over a thirty-four-year period for two contrasting sites in central Iowa. One site displayed increasing levels of urbanization over time and a dramatic decline in Culex pipiens group (an informal grouping of Culex restuans, Culex pipiens, and Culex salinarius, referred to as CPG), the primary vectors of West Nile virus in central Iowa. Similar effects were also shown for other mosquito vector populations, yet the abundance of Aedes vexans remained constant during the study period. This is in contrast to a second site, which reflected an established urban landscape. At this location, there were no significant changes in land use and CPG populations remained constant. Climate data (temperature, total precipitation) were compiled for each location to see if these changes could account for altered population dynamics, but neither significantly influence CPG abundance at the respective site locations. Taken together, our data suggest that increased landscape development can have negative impacts on Culex vector populations, and we argue that long-term surveillance paired with satellite imagery analysis are useful methods for measuring the impacts of rapid human development on mosquito vector communities. As a result, we believe that land use changes can have important implications for mosquito management practices, population modeling, and disease transmission dynamics.
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McLean, S. A., R. S. Phillips, C. D. Pearson, and D. Walliker. "The effect of mosquito transmission of antigenic variants of Plasmodium chabaudi." Parasitology 94, no. 3 (June 1987): 443–49. http://dx.doi.org/10.1017/s0031182000055797.
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SUMMARYPlasmodium chabaudi AS strain in mice is characterized by an acute primary parasitaemia, and one or more less acute recrudescences. Previous work has shown, using a passive protection assay, that the recrudescent parasites are usually antigenically different from parasites of the parent population with which the mice were first infected. In this study the effect of mosquito transmission on the antigenic expression of recrudescent populations of P. chabaudi was examined. In the first experiments the recrudescent population which was antigenically different from the parent population was uncloned. After transmission through Anopheles stephensi the recrudescent population appeared to revert to an antigenic type similar to that of the parent population. In the second experiment clones from a recrudescent population were mosquito transmitted and again the parasites of the primary patent parasitaemia in the mice, bitten by the infected mosquitoes, had reverted to the parental type. It is suggested that antigenic variants of P. chabaudi AS strain may revert to a basic type after mosquito transmission.
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Xia, Siyang, Jonah Ury, and Jeffrey R. Powell. "Increasing Effectiveness of Genetically Modifying Mosquito Populations: Risk Assessment of Releasing Blood-Fed Females." American Journal of Tropical Medicine and Hygiene 104, no. 5 (May 5, 2021): 1895–906. http://dx.doi.org/10.4269/ajtmh.19-0729.
Full textAbstract:
ABSTRACTReleasing mosquito refractory to pathogens has been proposed as a means of controlling mosquito-borne diseases. A recent modeling study demonstrated that instead of the conventional male-only releases, adding blood-fed females to the release population could significantly increase the program’s efficiency, hastening the decrease in disease transmission competence of the target mosquito population and reducing the duration and costs of the release program. However, releasing female mosquitoes presents a short-term risk of increased disease transmission. To quantify this risk, we constructed a Ross–MacDonald model and an individual-based stochastic model to estimate the increase in disease transmission contributed by the released blood-fed females, using the mosquito Aedes aegypti and the dengue virus as a model system. Under baseline parameter values informed by empirical data, our stochastic models predicted a 1.1–5.5% increase in dengue transmission during the initial release, depending on the resistance level of released mosquitoes and release size. The basic reproductive number (R0) increased by 0.45–3.62%. The stochastic simulations were then extended to 10 releases to evaluate the long-term effect. The overall reduction of disease transmission was much greater than the number of potential infections directly contributed by the released females. Releasing blood-fed females with males could also outperform conventional male-only releases when the release strain is sufficiently resistant, and the release size is relatively small. Overall, these results suggested that the long-term benefit of releasing blood-fed females often outweighs the short-term risk.
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Cuthbert, Ross N., Tatenda Dalu, Ryan J. Wasserman, Olaf L. F. Weyl, P. William Froneman, Amanda Callaghan, and Jaimie T. A. Dick. "Inter-Population Similarities and Differences in Predation Efficiency of a Mosquito Natural Enemy." Journal of Medical Entomology 57, no. 6 (May 27, 2020): 1983–87. http://dx.doi.org/10.1093/jme/tjaa093.
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Abstract Predation is a critical factor that mediates population stability, community structure, and ecosystem function. Predatory natural enemies can contribute to the regulation of disease vector groups such as mosquitoes, particularly where they naturally co-occur across landscapes. However, we must understand inter-population variation in predatory efficiency if we are to enhance vector control. The present study thus employs a functional response (FR; resource use under different densities) approach to quantify and compare predatory interaction strengths among six populations of a predatory temporary pond specialist copepod, Lovenula raynerae, from the Eastern Cape of South Africa preying on second instar Culex pipiens complex mosquito larvae. All individuals from the sampled populations were predatory and drove significant mortality through per capita predation rates of 0.75–1.10 mosquitoes/h at maximum densities over a 5-h feeding time. Individuals from all copepod populations exhibited Type II FRs with no significant differences in attack rates. On the other hand, there were significant differences in handling times, and therefore also maximum feeding rates (maximum experimental prey density: 32), suggesting possible genetic differences among populations that influenced predation. Owing to a widespread distribution in arid landscapes, we propose that predatory calanoid copepods such as L. raynerae play a key regulatory role at the landscape scale in the control of disease vector mosquito populations. We propose that these ecosystems and their specialist biota should thus be conserved and enhanced (e.g., via selective breeding) owing to the ecosystem services they provide in the context of public health.
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Hien, Nguyen T., Dang D. Anh, Nguyen H. Le, Nguyen T. Yen, Tran V. Phong, Vu S. Nam, Tran N. Duong, et al. "Environmental factors influence the local establishment of Wolbachia in Aedes aegypti mosquitoes in two small communities in central Vietnam." Gates Open Research 5 (September 24, 2021): 147. http://dx.doi.org/10.12688/gatesopenres.13347.1.
Full textAbstract:
Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown to reduce transmission of dengue and other pathogens, under both laboratory and field conditions. Here we describe the entomological outcomes of wMel Wolbachia mosquito releases in two small communities in Nha Trang City in central Vietnam. Methods: The wMel strain of Wolbachia was backcrossed into local Aedes aegypti genotype and mosquito releases were undertaken by community members or by staff. Field monitoring was undertaken to track Wolbachia establishment in local Ae. aegypti mosquito populations. Ecological studies were undertaken to assess relationships between environmental factors and the spatial and temporal variability in Wolbachia infection prevalence in mosquitoes. Results: Releases of wMel Wolbachia Ae. aegypti mosquitoes in two small communities in Nha Trang City resulted in the initial establishment of Wolbachia in the local Ae. aegypti mosquito populations, followed by seasonal fluctuations in Wolbachia prevalence. There was significant small-scale spatial heterogeneity in Wolbachia infection prevalence in the Tri Nguyen Village site, resulting in the loss of wMel Wolbachia infection in mosquitoes in north and center areas, despite Wolbachia prevalence remaining high in mosquitoes in the south area. In the second site, Vinh Luong Ward, Wolbachia has persisted at a high level in mosquitoes throughout this site despite similar seasonal fluctuations in wMel Wolbachia prevalence. Conclusion: Seasonal variation in Wolbachia infection prevalence in mosquitoes was associated with elevated temperature conditions, and was possibly due to imperfect maternal transmission of Wolbachia. Heterogeneity in Wolbachia infection prevalence was found throughout one site, and indicates additional factors may influence Wolbachia establishment.
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Reiner, Robert C., Carlos Guerra, Martin J. Donnelly, Teun Bousema, Chris Drakeley, and David L. Smith. "Estimating malaria transmission from humans to mosquitoes in a noisy landscape." Journal of The Royal Society Interface 12, no. 111 (October 2015): 20150478. http://dx.doi.org/10.1098/rsif.2015.0478.
Full textAbstract:
A basic quantitative understanding of malaria transmission requires measuring the probability a mosquito becomes infected after feeding on a human. Parasite prevalence in mosquitoes is highly age-dependent, and the unknown age-structure of fluctuating mosquito populations impedes estimation. Here, we simulate mosquito infection dynamics, where mosquito recruitment is modelled seasonally with fractional Brownian noise, and we develop methods for estimating mosquito infection rates. We find that noise introduces bias, but the magnitude of the bias depends on the ‘colour' of the noise. Some of these problems can be overcome by increasing the sampling frequency, but estimates of transmission rates (and estimated reductions in transmission) are most accurate and precise if they combine parity, oocyst rates and sporozoite rates. These studies provide a basis for evaluating the adequacy of various entomological sampling procedures for measuring malaria parasite transmission from humans to mosquitoes and for evaluating the direct transmission-blocking effects of a vaccine.
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Sroute, Lamyae, Brian D. Byrd, and Scott W. Huffman. "Classification of Mosquitoes with Infrared Spectroscopy and Partial Least Squares-Discriminant Analysis." Applied Spectroscopy 74, no. 8 (August 2020): 900–912. http://dx.doi.org/10.1177/0003702820915729.
Full textAbstract:
Mosquito-borne diseases are responsible for considerable morbidity and mortality globally. Given the absence of effective vaccines for most arthropod-borne viruses, mosquito control efforts remain the dominant method of disease prevention. Ideal control efforts begin with entomologic surveillance in order to determine the abundance, identity, and infection status of pathogen-vectoring mosquito populations. Traditionally, much of the surveillance work involves morphological species identification by trained entomologists. Limited operational funding and lack of specialized training is a known barrier to surveillance and effective control efforts for many operational mosquito control personnel. Therefore, there is a need for surveillance workflow improvements and rapid mosquito identification methods. Herein, is presented a proof of concept study in which infrared spectroscopy coupled with partial least squares-discriminant analysis was explored as a means of automatically classifying mosquitoes at the species level. The developed method resulted in greater than 94% accuracy for four mosquitoes of public health relevance: Aedes aegypti, Aedes albopictus, Aedes japonicus, and Aedes triseriatus.
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Nebbak, Amira, Sonia Monteil-Bouchard, Jean-Michel Berenger, Lionel Almeras, Philippe Parola, and Christelle Desnues. "Virome Diversity among Mosquito Populations in a Sub-Urban Region of Marseille, France." Viruses 13, no. 5 (April 27, 2021): 768. http://dx.doi.org/10.3390/v13050768.
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Some mosquito species have significant public health importance given their ability to transmit major diseases to humans and animals, making them the deadliest animals in the world. Among these, the Aedes (Ae.) genus is a vector of several viruses such as Dengue, Chikungunya, and Zika viruses that can cause serious pathologies in humans. Since 2004, Ae. albopictus has been encountered in the South of France, and autochthonous cases of Dengue, Chikungunya, and Zika diseases have recently been reported, further highlighting the need for a comprehensive survey of the mosquitoes and their associated viruses in this area. Using high throughput sequencing (HTS) techniques, we report an analysis of the DNA and RNA viral communities of three mosquito species Ae. albopictus, Culex (Cx.) pipiens, and Culiseta (Cs.) longiareolata vectors of human infectious diseases in a small sub-urban city in the South of France. Results revealed the presence of a significant diversity of viruses known to infect bacteria, plants, insects, and mammals. Several novel viruses were detected, including novel members of the Rhabdoviridae, Totiviridae, Iflaviviridae, Circoviridae, and Sobemoviridae families. No sequence related to major zoonotic viruses transmitted by mosquitoes was detected. The use of HTS on arthropod vector populations is a promising strategy for monitoring the emergence and circulation of zoonoses and epizooties. This study is a contribution to the knowledge of the mosquito microbiome.
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Caragata, E. P., S. Dong, Y. Dong, M. L. Simões, C. V. Tikhe, and G. Dimopoulos. "Prospects and Pitfalls: Next-Generation Tools to Control Mosquito-Transmitted Disease." Annual Review of Microbiology 74, no. 1 (September 8, 2020): 455–75. http://dx.doi.org/10.1146/annurev-micro-011320-025557.
Full textAbstract:
Mosquito-transmitted diseases, including malaria and dengue, are a major threat to human health around the globe, affecting millions each year. A diverse array of next-generation tools has been designed to eliminate mosquito populations or to replace them with mosquitoes that are less capable of transmitting key pathogens. Many of these new approaches have been built on recent advances in CRISPR/Cas9-based genome editing. These initiatives have driven the development of pathogen-resistant lines, new genetics-based sexing methods, and new methods of driving desirable genetic traits into mosquito populations. Many other emerging tools involve microorganisms, including two strategies involving Wolbachia that are achieving great success in the field. At the same time, other mosquito-associated bacteria, fungi, and even viruses represent untapped sources of new mosquitocidal or antipathogen compounds. Although there are still hurdles to be overcome, the prospect that such approaches will reduce the impact of these diseases is highly encouraging.