Relevant bibliographies by topics / Morpholino Monomers

Academic literature on the topic 'Morpholino Monomers'

Author: Grafiati
Published: 7 September 2023

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Journal articles on the topic "Morpholino Monomers"

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Paul, Sibasish, Bappaditya Nandi, Sankha Pattanayak, and Surajit Sinha. "Synthesis of 5-alkynylated uracil–morpholino monomers using Sonogashira coupling." Tetrahedron Letters 53, no. 32 (August 2012): 4179–83. http://dx.doi.org/10.1016/j.tetlet.2012.05.141.

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Paul, Sibasish, Santanu Jana, Jhuma Bhadra, and Surajit Sinha. "Photophysical studies and submicron ring formation of morpholino U-nucleoside monomers." Chemical Communications 49, no. 96 (2013): 11278. http://dx.doi.org/10.1039/c3cc45082a.

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Paul, Sibasish, Bappaditya Nandi, Sankha Pattanayak, and Surajit Sinha. "ChemInform Abstract: Synthesis of 5-Alkynylated Uracil-Morpholino Monomers Using Sonogashira Coupling." ChemInform 43, no. 47 (October 30, 2012): no. http://dx.doi.org/10.1002/chin.201247164.

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Vejlegaard, Kim, Sibasish Paul, Tamer Kosbar, Jesper Wengel, and Marvin H. Caruthers. "Oligodeoxynucleotides containing 2′-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers." Bioorganic & Medicinal Chemistry Letters 27, no. 14 (July 2017): 3173–76. http://dx.doi.org/10.1016/j.bmcl.2017.05.023.

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Pattanayak, Sankha, Sibasish Paul, Bappaditya Nandi, and Surajit Sinha. "Improved Protocol for the Synthesis of Flexibly Protected Morpholino Monomers from Unprotected Ribonucleosides." Nucleosides, Nucleotides and Nucleic Acids 31, no. 11 (November 2012): 763–82. http://dx.doi.org/10.1080/15257770.2012.724491.

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Cale, Jessica M., Kane Greer, Sue Fletcher, and Steve D. Wilton. "Proof-of-Concept: Antisense Oligonucleotide Mediated Skipping of Fibrillin-1 Exon 52." International Journal of Molecular Sciences 22, no. 7 (March 27, 2021): 3479. http://dx.doi.org/10.3390/ijms22073479.

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Abstract:
Marfan syndrome is one of the most common dominantly inherited connective tissue disorders, affecting 2–3 in 10,000 individuals, and is caused by one of over 2800 unique FBN1 mutations. Mutations in FBN1 result in reduced fibrillin-1 expression, or the production of two different fibrillin-1 monomers unable to interact to form functional microfibrils. Here, we describe in vitro evaluation of antisense oligonucleotides designed to mediate exclusion of FBN1 exon 52 during pre-mRNA splicing to restore monomer homology. Antisense oligonucleotide sequences were screened in healthy control fibroblasts. The most effective sequence was synthesised as a phosphorodiamidate morpholino oligomer, a chemistry shown to be safe and effective clinically. We show that exon 52 can be excluded in up to 100% of FBN1 transcripts in healthy control fibroblasts transfected with PMO52. Immunofluorescent staining revealed the loss of fibrillin 1 fibres with ~50% skipping and the subsequent re-appearance of fibres with >80% skipping. However, the effect of exon skipping on the function of the induced fibrillin-1 isoform remains to be explored. Therefore, these findings demonstrate proof-of-concept that exclusion of an exon from FBN1 pre-mRNA can result in internally truncated but identical monomers capable of forming fibres and lay a foundation for further investigation to determine the effect of exon skipping on fibrillin-1 function.
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7

Nandi, Bappaditya, Sankha Pattanayak, Sibasish Paul, and Surajit Sinha. "Synthesis of Nucleobase-Functionalized Morpholino-Modified Nucleoside Monomers Through Palladium-Catalyzed Cross-Coupling Reactions." European Journal of Organic Chemistry 2013, no. 7 (January 18, 2013): 1271–86. http://dx.doi.org/10.1002/ejoc.201201384.

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8

Pattanayak, Sankha, Sibasish Paul, Bappaditya Nandi, and Surajit Sinha. "ChemInform Abstract: Improved Protocol for the Synthesis of Flexibly Protected Morpholino Monomers from Unprotected Ribonucleosides." ChemInform 44, no. 17 (April 4, 2013): no. http://dx.doi.org/10.1002/chin.201317042.

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9

Nandi, Bappaditya, Sankha Pattanayak, Sibasish Paul, and Surajit Sinha. "ChemInform Abstract: Synthesis of Nucleobase-Functionalized Morpholino-Modified Nucleoside Monomers Through Palladium-Catalyzed Cross-Coupling Reactions." ChemInform 44, no. 35 (August 8, 2013): no. http://dx.doi.org/10.1002/chin.201335159.

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Grigale-Soročina, Zane, Elina Vindedze, Julija Kozela, and Ingmārs Birks. "Evaluation of Reactive Diluent Impact on Stability of Systems Viscosity in UV-Curable Compositions." Solid State Phenomena 320 (June 30, 2021): 150–54. http://dx.doi.org/10.4028/www.scientific.net/ssp.320.150.

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This study investigated the impact of various reactive diluents on viscosity of uncured mixture at 50 °C over a 12-week period. This criterion is important to predict the shelf life of uncured composition. Studied mono-functional acrylate monomers were: hydroxypropyl methacrylate (HPMA), hydroxyethyl methacrylate (HEMA), tetrahydrofurfuryl acrylate (THFA), isobornyl methacrylate (IBOMA), isobornyl acrylate (IBOA), 2-(2-Ethoxyethoxy)ethyl acrylate (EOEOEA), acryloyl morpholine (ACMO), glacial methacrylic acid (GMAA) and phosphate acrylate monomer (PAM); and various solvents: isopropanol(IP) ethyl acetate (EA), butyl acetate (BA). There was found the difference of effect on the systems viscosity in time between the mono-functional monomers and solvents. HPMA and IPA showed the most stable viscosity values in time.
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Book chapters on the topic "Morpholino Monomers"

1

Nandi, Bappaditya, Sankha Pattanayak, Sibasish Paul, Jayanta Kundu, and Surajit Sinha. "Synthesis of Nucleobase-Functionalized Morpholino Monomers." In Methods in Molecular Biology, 107–30. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9216-4_7.

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2

Abdelmelek, Mena, Mary Nguyen, Valerie Bradford, Brent Iverson, and Laura Suggs. "Synthesis of Morpholine-2,5-dione Monomers for the Preparation of Polydepsipeptides." In ACS Symposium Series, 185–96. Washington, DC: American Chemical Society, 2010. http://dx.doi.org/10.1021/bk-2010-1054.ch010.

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