Dissertations / Theses on the topic 'Morphogenesis'
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Thomas, Nicole. "Bone morphogenetic proteins and hair and wool follicle morphogenesis." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09pht4592.pdf.
Full textCOSBITT, NICOLE. "MORPHOGENESIS: BUILDING AS A NATIVE PLANT." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179327038.
Full textCocho, Bermejo Ana. "EmDeplo morphogenesis." Doctoral thesis, Universitat Politècnica de Catalunya, 2012. http://hdl.handle.net/10803/97040.
Full textEsta tesis debatira la importancia de la Arquitectura Parametrica Dinamica versus la Arquitectura Parametrica Estatica.Describiento el actual escenario arquitectonico y algoritmico dentro del cual el "Emergency Deployable System" emergio,sera debatida la importancia de la adaptabilidad como el concepto perdido actualmente el la arquitectura parametrica. Desarrollando el concepto de "Human Oriented Parametric Architecture", sera discutida la necesidad de implementar el tiempo como el parametro perdido en los actuales procedimientos de diseño. Empleando el edificio Media-Tic, del arquitecto español Enrique Ruiz Geli, como un ejemplo de un diseño actual que intenta implementar nuevas tecnologias e ideas parametricas en su proceso de diseño,sera explicada la idea de la necesidad del edificio de trabajar con el entorno, no de defenderse contra el, como base para una buena adaptabilidad. El diseño de Geli usa 104 chipsArduino para un control y comportamiento individual de los 104 cojines de ETFe en su fachada. A traves de la creacion de un sistema virtual estimulo-reaccion de la fachada versus un modelo virtual en el cual el aprendizaje de maquinas ha sido implementado para un mejor comportamiento ambiental, la eficacia de ambos modelos sera compararda. La idea de los procesos Morfogeneticos sera discutida a traves del pricipio de una mebrana adaptable, como la solucion propuesta para la mejora futura del proceso de diseño arquitectonico. Un modelo implementando un unico Arduino en la fachada, controlara el comportamiento de los patrones de la fachada a traves de una Red Neuronal Artificial que decidira el tipo de escenario de entorno en que el edificio se encuentra, activando un Algoritmo Genetico que optimizara el aislamiento termico de os cojines ETFE. La maqueta virtual final sera capaz de llegar a la meta propuesta para esta tesis doctoral, una temperatura homogenea en todos los espacios del edificio de 22ºC. La maxima optimizacion termica obtenida, sin embargo, aparece si la posibilidad de apertura de los cojines ETFE es libre en un intervalo entre o y 1m de espesor. La reduccion de las posibilidades de apertura de los cojines a tres posiciones unicamente, sera demostrada como una posibilidad mejoor que el comportamiento estimulo-reaccion, sin embargo, mucho menos efectivo que una posibilidad de apertura de rango libre. El sistema EmDeplo funcionara con un comportamiento global, la variabilidad del patron de la fachada, pero tambien con un comportamiento local, el de cada cojin ETFE, dando la opcion de un control de sombra-sol individual. El aprendizaje de maquinas implementado dara a la fachada la posibilidad de aprender de la eficacia de sus decisiones a lo largo del tiempo, eliminando la necisidad de un comportamiento on-off para defenderse del entorno. En lugar de esta defensa, trabajara con el, adaptamdose a el, y evolucionando con su variabilidad.
Saygun, Yakup. "Computational Stochastic Morphogenesis." Thesis, Uppsala universitet, Avdelningen för beräkningsvetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-257096.
Full textNelsen, Brian. "Morphogenesis a theory of places /." This title; PDF viewer required. Home page for entire collection, 2010. http://archives.udmercy.edu:8080/dspace/handle/10429/9.
Full textBriggs, Laura Joanne. "Flagellar morphogenesis in Trypanosoma brucei." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427895.
Full textHooley, Clare Verity. "Morphogenesis of Drosophila renal tubules." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604211.
Full textFarzaneh, Ali. "Computational morphogenesis of city tissues." Thesis, Open University, 2017. http://oro.open.ac.uk/49302/.
Full textBunt, Stephanie Marie. "Renal tubule morphogenesis in Drosophila." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612231.
Full textRauzi, Matteo. "Mapping Subcellular Forces Controlling Morphogenesis." Thesis, Aix-Marseille 2, 2010. http://www.theses.fr/2010AIX22025.
Full textDuring embryonic development tissue remodeling leads to shape changes: for example, tissues can elongate, invaginate, and stretch. Distinct signaling pathways regulate in space and time these behaviors through the control ofthe actin cytoskeleton and of myosin-based tension required for cell shapechange. What is the spatiotemporal pattern of subcellular forcesthat orient tissue morphogenesis? What is the nature of the generated forces and finally, what lies at the origin of such forces? These are the main questions that my thesis tries to illuminate. I use the germbandelongation of the Drosophila embryo as a model system to investigate themechanics of tissue morphogenesis
Balbi, Valentina. "Modeling morphogenesis in living matter." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066382/document.
Full textAmong the fundamental processes involved in the development of an organism, morphogenesis is one of the most complex. During the past centuries, an amount of experimental studies have improved our actual knowledge of the mechanisms which drive many morphogenetic processes in living organisms. Only recently, experiments have been complemented with mathematical modeling as a tool for proving novel insights on morphogenesis in soft tissues. In this context, this thesis aims at developing new mathematical models for the formation of patterns and forms in soft tubular organs. A macroscopic approach is adopted, where the tissue is considered as a continuum body undergoing growth and remodeling. The main idea behind the proposed models is that during growth and remodeling, residual stresses can arise and once they exceed a critical value, an elastic instability can occur in the tissue and lead to a morphological change. Therefore, the morphoelastic models are developed integrating the modern theories of growth and remodeling within the framework of the thermo-mechanics of open systems. The occurrence of the elastic instability is investigated using the method of incremental deformations superposed on finite deformations. The critical thresholds for the onset of the instability are determined together with the modes of the associated instability pattern. The morphoelastic theory is applied to the modeling of different morphogenetic processes occurring in soft tubular organs and gives useful insights in two interesting problems: the formation of the wide range of patterns in the gastro-intestinal system and the occurrence of torsional instabilities in pre-stressed tubular organs
Ding, Mei. "Epidermal morphogenesis in Caenorhabditis elegans /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2004. http://uclibs.org/PID/11984.
Full textLehmann, Naida L. "Homeosis in floral development emphasizing the perianth and androecium." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28820.
Full textCaraguel, Flavien. "Prolifération au cours de la régénération de la forme bilobée de la nageoire et de la peau lépidogène chez le zébrafish." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENS043/document.
Full textCaudal fin and skin regeneration in zebrafish both require new tissues formation, structurally and functionally identical to the former ones. They imply the formation and especially the proliferation of progenitor cells, and then during a patterning phase, they differentiate into a well-organized structure.During my PhD, I have studied in zebrafish model the proliferative events that conduct to the neoformation of caudal fin in one hand and the proliferative events implicated in the cutaneous wound healing in the other hand.The first part of this work supports the evidences of a common saltatory growth mechanism in both regeneration and development of caudal fin bony rays, and that the bi-lobed shape restoration of the fin could be a consequence of this bony segment salutary growth.During skin wound healing, proliferation is necessary in order to allow dermis and epidermis neo-morphogenesis and these events are over before the scale formation is initiated. In the second part of this study I characterized the entire skin wound healing process in the zebrafish model, from the wound closure to a fully regenerated skin including appendages. According to my results, the wound closure is a very fast event completed only in a few hours and it occurs only by epidermal cells migration. Cellular proliferation was detected after complete wound closure and once the epidermal basal layer differentiation is achieved. Cell proliferation appears to be restricted to a few basal cells whereas the major proliferation is detected in the intermediates layers of the epidermis.Taken together, these results suggest that in teleosteans, the epidermal stem cells and transient cells might be respectively located in the basal and intermediate layers. Moreover, there might be a common process due to aquatic environment, leading to a fast wound closure by re-epithelialization, between teleost skin and mammal’s cornea as well as oral mucosa
Böhm, Bernd R. "Quantitative modelling of mouse limb morphogenesis." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/31967.
Full textEn esta tesis tratamos de testar una bien establecida teor´ıa sobre los mecanismos celulares que promueven de la elongaci´on de las extremidades. Para eso combinamos mediciones cuantitativas del proceso morfogen ´etico de la extremidad del rat´on con modelos computacionales. Se cre´ıa que la fuerza conductora del crecimiento de las extremidades era un gradiente en sentido distal del incremento de la proliferaci´on celular. Descubrimos que el patr´on de proliferaci´on celular basado en medidas emp´ıricas no consegu´ıa promover un desarrollo normal, mientras que un algoritmo de ingenier´ıa inversa aplicado al proceso revel´o un patr´on que si podr´ıa. La diferencia entre estos dos patrones es inmensa y sugiere que la proliferaci´on celular isotropica por si sola tiene muy poco impacto sobre la morfog´enesis de las extremidades, indicando as´ı la necesidad de que otros procesos no isotr´opicos se hallen involucrados.
Okuda, Satoru. "Multicellular Biomechanical Simulation of Tissue Morphogenesis." 京都大学 (Kyoto University), 2013. http://hdl.handle.net/2433/174923.
Full text0048
新制・課程博士
博士(工学)
甲第17557号
工博第3716号
新制||工||1566(附属図書館)
30323
京都大学大学院工学研究科マイクロエンジニアリング専攻
(主査)教授 安達 泰治, 教授 楠見 明弘, 准教授 井上 康博, 教授 琵琶 志朗
学位規則第4条第1項該当
Cosbitt, Nicole. "Morphogenesis building as a native plant /." Cincinnati, Ohio : University of Cincinnati, 2007. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1179327038.
Full textTitle from PDF t.p. (viewed on July 17, 2007.) Keywords: morphogenesis, morphogenetic design, emergence, emergent design. Includes bibliographical references.
Painter, Kevin John. "Chemotaxis as a mechanism for morphogenesis." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389127.
Full textBilsborough, G. D. "Leaf margin morphogenesis in crucifer plants." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:7304164b-d674-4cef-a899-947d8497bd13.
Full textLeng, P. "Control of morphogenesis in Candida albicans." Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.592939.
Full textHorne, Kirsty L. "Characterisation of morphogenesis mutants in Arabidopsis." Thesis, Durham University, 1998. http://etheses.dur.ac.uk/4892/.
Full text許霖慶 and Lam-hing Hui. "Studies on explant regeneration and morphogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1985. http://hub.hku.hk/bib/B3120692X.
Full textRussell, Angela Julia. "Morphogenesis in the moss Physcomitrella patens." Thesis, University of Leeds, 1993. http://etheses.whiterose.ac.uk/1535/.
Full textKolatsi, Maria. "Hepatocyte growth factor and renal morphogenesis." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243452.
Full textHeyman, Isobel. "Morphogenesis and differentiation of rhombomere boundaries." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283288.
Full textArcher, Julie Elizabeth. "Analysis of microtububule morphogenesis in vivo." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/41002.
Full textBhattacharyya, Arnab. "Modelling morphogenesis as an amorphous computation." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/36794.
Full textIncludes bibliographical references (leaves 57-58).
This thesis presents a programming-language viewpoint for morphogenesis, the process of shape formation during embryological development. We model morphogenesis as a self-organizing, self-repairing amorphous computation and describe how we can program large-scale shape formation by giving local instructions to cell-like objects. Our goal is to simulate systems that display properties, like robustness, regeneration, and evolvability, that are present in biological systems but ordinarily not present in computer systems. Consistent with the theory of facilitated variation from evolutionary biology, we find that many of these properties can be introduced and conserved by a hierarchical organization of growth specification.
by Arnab Bhattacharyya.
M.Eng.
Brodsky, Micah Z. (Micah Zev). "Synthetic morphogenesis : space, time, and deformation." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/92963.
Full textThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 127-133).
Synthetic biology has presented engineers with a fascinating opportunity: can we understand the principles of our origins { animal embryonic development - by re-engineering it in the laboratory? I investigate, from an engineer's perspective, some of problems that arise in developing geometric form in a deformable substrate. More abstractly, I attack the problem of establishing spatial patterns, when rearranging and deforming parts of the system is inherent to the process. Deformable, foam-like cellular surfaces are developed as a model for embryonic epithelia (polarized cellular sheets), one of the principal tissue types in early animal development. I explore ways in which simple agent programs running within the individual cells can collectively craft large-scale structures. The mechanical properties of the substrate prove crucial to the patterning process. In such a distributed, heterogeneous substrate, little can be assumed about the progress of time. In one branch of my work, I develop patterning techniques where convergence is transparently and locally detectable, drawing insights from clockless digital circuits and casting the problem as distributed constraint propagation. In another branch of work, I avoid the problem of timing by making all patterns self- correcting. In self-correcting patterning, I attempt to understand "canalization" - how development is naturally robust to perturbations. I formulate a model for regional patterning, inspired by regeneration experiments in developmental biology, and using mathematical principles from classical models of magnetic domains and phase separation. The problem again becomes a form of distributed constraint propagation, now using soft constraints. I explore some of the resulting phenomena and then apply the mechanism to crafting surface geometries, where self-correction makes the process robust to both damage and self-deformation. I conclude with a look at how this naturally leads to an example of partial redundancy { multiple systems that partly but not completely overlap in function - yielding confusing responses to the effects of virtual knock-out experiments, reminiscent of the confusing behavior of knock-out experiments in biology.
by Micah Z. Brodsky.
Ph. D.
Giorgi, Mario. "Mechanobiological predictions of fetal joint morphogenesis." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/28582.
Full textBrown, James. "Cell wall morphogenesis in Bacillus subtilis." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3373.
Full textAnderson, Kerri-Ann. "A Mathematical Model of Cytokinetic Morphogenesis." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429607984.
Full textDivakaruni, Arun Venkat. "Control of morphogenesis in Caulobacter crescentus." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1428838421&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Full textHui, Lam-hing. "Studies on explant regeneration and morphogenesis /." [Hong Kong : University of Hong Kong], 1985. http://sunzi.lib.hku.hk/hkuto/record.jsp?B1231481X.
Full textEnemchukwu, Nduka Obichukwu. "Bioartificial matrices to modulate epithelial morphogenesis." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52938.
Full textAbad, Vivero Ursula Citlalli. "Morphogenesis at the shoot Apical Meristem." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEN088/document.
Full textThe process of morphogenesis is driven by cell division and expansion, which are controlled ina differential manner among cell types and tissues. In plants, the above ground organs arecontinuously produced by the shoot apical meristem (SAM), where the initiation of newprimordia is triggered by the local accumulation of the plant hormone auxin. We study theprocess of morphogenesis in the inflorescence of Arabidopsis thaliana, where flowers areformed in a regular pattern from the SAM.The DNA-binding auxin response factor ARF5/MP plays a central role in the initiation offlowers. After its activation, it induces the expression of LEAFY, AINTEGUMENTA andAINTEGUMENTA-LIKE6 transcription factors necessary for the specification of floralidentity and proliferative growth. However, at the cellular level, the initiation of lateraloutgrowths depends on regional differences in growth. In plant cells, these processes areregulated via modifications of the cell wall. Auxin and its downstream targets are also involvedin these processes, by activating changes in the dynamics of the cortical microtubules, whichresult in changes in growth direction. Auxin also slightly reduces wall rigidity prior to organoutgrowth in the SAM, which results in changes in growth rate. This is correlated with thetranscriptional activation of a number of cell wall modifying genes.Thus, auxin signaling regulates primordium initiation by integrating the activation of atranscriptional regulatory network and both the stiffness and anisotropy of the cell wall, whichdirectly influence the rate and direction of growth.The findings of this thesis provide evidence indicating that the mechanisms of organ initiationat the SAM involve feedbacks where changes in the local properties of the cell wall influencethe molecular regulation of the transcriptional regulatory network. Our results suggest that thismight require the influence from other hormones, different from auxin, that funnel theinitiation of lateral outgrowths
Partridge, Roland William. "Morphogenesis and morphology of intestinal villi." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28884.
Full textPoulain, Fabienne. "Stathmin family phosphoproteins and neuronal morphogenesis." Paris 6, 2007. http://www.theses.fr/2007PA066492.
Full textSchliffka, Markus. "Multiscale study of mouse preimplantation morphogenesis." Electronic Thesis or Diss., Université Paris sciences et lettres, 2023. http://www.theses.fr/2023UPSLS021.
Full textDuring development, embryos undergo a complex sequence of morphogenetic shape changes powered by cellular contractile forces which allow the embryo to correctly form tissues and organs. Contractile cellular forces in morphogenesis are chiefly generated by the actomyosin cytoskeleton. In the mammalian embryo, morphogenesis begins during preimplantation development, which commences with fertilization and leads up to the formation of the blastocyst, the structure that implants into the maternal uterus. During preimplantation development, the embryo undergoes a series of contractility-driven morphogenetic steps that culminate in the positioning of the first lumen of development in the blastocyst.Here, we conducted the first study investigating the effect of complete contractility loss on preimplantation development. We performed single and double maternal-zygotic knockout of the non-muscle myosin heavy chain genes Myh9 and Myh10, which allowed us to study the relative contribution of these two paralogs to contractility generation in preimplantation development. We found that Myh9 is the main contributor in this process, as its maternal-zygotic loss results in cell cycle delay, reduced cell number, compaction and differentiation. Loss of Myh10 did not have a strong detectable impact compared to wildtype embryos. Nevertheless, a more severe phenotype could be observed in Myh9 and Myh10 double knockout embryos as cytokinesis failed in most cases, suggesting some compensation by Myh10 in Myh9 single mutants. Despite severely reduced cell number, differentiation and lumen formation still somehow continued in double knockout embryos. In the most extreme cases, single-celled embryos accumulated fluid in intracellular compartments, indicating that the preimplantation developmental program is executed independently of cell number.In WT embryos, the blastocyst forms in a process of hydraulic fracturing producing hundreds of microlumen followed by their coarsening into a single lumen surrounded by multiple cells. While the global mechanism of this process is understood, it remains unclear how cells regulate microlumen dynamics locally. Here, we describe inverse blebs at cell-cell contacts during microlumen formation. Inverse blebs are short-lived membrane protrusions expanding into the cytoplasm before being retracted by actomyosin contraction. We show that inverse blebs form due to a global increase in intercellular fluid pressure and require local fluid confinement by cell-cell adhesion. We propose that inverse blebs serve as hydraulic pumps to push the fluid within the microlumen network, thereby supporting the coarsening of the first mammalian lumen.Together, these finding expand our molecular, cellular and physical understanding of how cell contractility shapes the early mammalian embryo
Deacon, William Jack. "Quantification of cell and tissue behaviours during morphogenesis." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610643.
Full textJoglekar, Chandrashekhar. "Widerborst Interacts With Bitesize To Regulate Wing Hair Morphogenesis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1122295800716-91033.
Full textBurn, Sally. "Origin and morphogenesis of the murine spleen." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/23965.
Full textSidhaye, Jaydeep. "Cellular dynamics in Zebrafish optic cup morphogenesis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-232445.
Full textFür die Entwicklung eines Organismus ist die Bildung von Organen (Organogenese) von zentraler Bedeutung. Organogenese umfasst Prozesse auf allen Ebenen der Längenskala: von der molekularen Ebene, der Gewebeebene, bis hin zur Ebene des ganzen Organismus. Viele Phänomene der Organogenese beinhalten dabei Veränderungen von Epithelien, bei der sich Schichten von Zellen zu komplexen Strukturen - Organvorläufern - umwandeln. Diese entwickeln sich später zu vollständigen Organen. Die rechtzeitige Entwicklung der charakteristischen Architektur der Organvorläufer ist entscheidend für eine erfolgreiche Organogenese und wird durch die Wahl der epithelialen Umwandlungsprozessen bestimmt, welche die Zellen in Raum und Zeit koordinieren müssen. Für viele dieser Prozesse ist jedoch genau diese zugrundeliegende Zelldynamik unklar. In der hier vorgestellten Arbeit untersuchte ich die Bildung des hemisphärischen retinalen Neuropepithels (RNE). Das RNE ist der Organvorläufer der neuralen Retina, weshalb dessen korrekte Bildung die Voraussetzung für die korrekte Entwicklung der Augen ist. Ich untersuchte die RNE-Morphogenese in sich entwickelnden Zebrafisch-Embryos durch Visualisierung und Untersuchung der zellulären Dynamik der beteiligten Prozesse in vivo. Meine Ergebnisse zeigen, dass das RNE in Zebrafischen durch die kombinierte Umwandlung von zwei verschiedenen Epithelien geformt wird. Zum einen findet eine Verkleinerung des basalen Prozesses der neuroepithelialen Zellen statt, zum anderen die Involution von Randzellen. Die basale Verkleinerung der neuroepithelialen Zellen verbiegt die neuroepitheliale Schicht und führt zur Einstülpung des RNE. Meine Ergebnisse zeigten allerdings, dass Involution von Randzellen noch bedeutsamer für die RNE-Morphogenese ist. Die involution von Randzellen transportiert potenzielle RNE-Zellen in das Neuroepithel und trägt zur RNE-Einstülpung bei. Die Bedeutung meiner Arbeit liegt darin, den bisher unbekannten Mechanismus der Randzell-Involution entdeckt zu haben. Ich zeigte, dass die Randzellen sich aktiv durch kollektive epitheliale Migration bewegen indem sie gerichtete Membranforsätze und dynamische Zell zu Matrix Kontakte etablieren. Wird die Migration der Randzellen inhibiert, so führt dies dazu, dass diese Zellen die eingestülpte RNE Schicht nicht erreichen. Sie landen dann an den falschen Positionen, wo sie die Gewerbearchitektur stören können. Daher koordiniert die Randzellmigration die Position der Zellen und orchestriert die RNE-Morphogenese in Raum und Zeit. Insgesamt zeigt meine Arbeit, wie morphogenetische Prozesse die Organvorläuferarchitektur prägen und eine rechtzeitige Organbildung sicherstellen. Diese Erkenntnisse sind sowohl für das Verständnis der Augenentwicklung, als auch für das der epithelialen Morphogenese und Organogenese in anderen Systemen von großer Bedeutung
Pedersen, Roberta Vicki Kostiw. "Morphogenesis of planktotrophic veligers of naticidean gastropods." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0006/MQ32675.pdf.
Full textKachurina, Nadezda. "Morphogenesis of opaque form «Candida albicans» cells." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40831.
Full textRÉSUMÉ Nous avons déterminé la localisation de l'actine ainsi que de la myosine I (Myo5) et de la septine (Cdc12) modifiées avec la protéine fluorescente verte (GFP) chez Candida albicans en phase opaque (reproductive) et blanche (végétative). Plus particulièrement, nous avons porté notre attention sur les processus associé à la reproduction tel le bourgeonnement et l'expansion cellulaire (shmoo), la conjugaison et la fusion cellulaire, le bourgeonnement et le développement des zygotes (cellules -filles issues de la conjugaison). Nous avons aussi observé la configuration subcellulaire de Myo5p, Cdc12p et de l’actine lors de la migration et de la division nucléaire en phase blanche. Que ce soit en phase opaque ou en phase blanche, la localisation de Myo5p, Cdc12p et de l'actine reste similaire lors du bourgeonnement. Lors d’une stimulation à la phéromone, en phase opaque, ces trois protéines ont le même patron d’organisation cellulaire que lors de la formation d'hyphes en phase blanche. Les cellules de type MTLa produisent des shmoo entre 5 et 7 heures plus tôt que les cellules de type MTLα dans une population mixte. Dans les zygotes, Cdc12p, Myo5p et l'actine ont la même localisation que celle observée dans les cellule-filles issues du bourgeonnement en mode végétatif. Étonnamment, l'isogénicité du locus génétique déterminant le type sexuel de la cellule influence la position du noyau lors de la division; Ainsi, dans 70% des cas, le noyau des cellules de type MTLa se divise à l'intérieur de la cellule-mère plutôt qu'au travers du col entre la cellule-mère et le bourgeon.
Rymar, Vladimir. "Novel aspects of the mammalian forebrain morphogenesis." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66743.
Full textCette dissertation avait pour but de mettre l'accent sur les caractéristiques de la neurogénèse des interneurones du téléencéphale mammifère, principalement dans le cortex et les corps striés, tout en comparant les motifs de neurogénèse des neurones projectrices. De plus, nous nous sommes attardés aux populations neuronales des corps striés et leurs mécanismes de survie dits antérogrades thalamostriataux survenant dans le développement postnatal et de leurs possibles implications dans la maladie de Huntington. Curieusement, la plupart sinon tous les interneurones provenant du striatum et du cortex, dû moins dans les rongeurs, originent loin des zones germinales de ces divisions téléencéphaliques. Les interneurones exprimants la parvalbumine et la calrétinine, lesquels représentent la majorité des sous-populations d'interneurones GABAergiques dans le striatum et le cortex, proviennent respectivement des zones germinales des éminences ganglioniques latérale et médiale. Dans le second chapitre de cette thèse, une évaluation temporielle de la neurogénèse ainsi que des gradients des interneurones à calrétinine furent determinés avec l'aide de bromo-deoxyuridine ainsi que de la stéréologie tout en considérant la compartimentalization patch/matrice.Ces résultats furent comparés avec des modèles de neurogénèses appartenant à d'autres interneurones des corps striés et des sous-catégories de neurones projectrices qui ont été précedemment décrites par des collègues de notre laboratoire.Dans le troisième chapitre de cette thèse, nous comparons des modèles de neurogénèse d'interneurones contenant de la parvalbumine et de la calrétinine avec des neurones projectrices appartenants aux six couches du cortex somatosensoriel ainsi qu'avec leurs comparses interneurones du cortex. Curieusement, les interneurones corticaux exprimant la parvalbumine et la calrétinine ont$
Vrljicak, Pavle J. "Role of Smads during renal branching morphogenesis." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19397.
Full textCampbell, K. A. "Cell polarity and tissue morphogenesis in Drosophila." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597249.
Full textFox, Helen. "PP1 localisation and function during fungal morphogenesis." Thesis, University of East Anglia, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327586.
Full textIsherwood, Beverley Jane. "Hepatitis C virus : particle assembly and morphogenesis." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410179.
Full textGraham, Helen K. "Studies of collagen fibrillogenesis during tendon morphogenesis." Thesis, University of Manchester, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488298.
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