Journal articles: 'Morphic Resonance'

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Maslin, Peter. "Morphic resonance." British Homeopathic Journal 83, no. 04 (October 1994): 246. http://dx.doi.org/10.1016/s0007-0785(05)80824-5.

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Van Galen, E. "Homœopathy and morphic resonance." British Homeopathic Journal 83, no. 02 (April 1994): 63–67. http://dx.doi.org/10.1016/s0007-0785(94)80004-9.

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AbstractOn a theoretical basis, the possible relation is discussed between the ‘morphic resonance’ theory of Dr Rupert Sheldrake and its possible contribution to establishing homœopathy in a scientific frame. Sheldrake's hypotheses on ‘formative causation’ and morphic resonance initially influenced biological views on the processes of evolution and have been verified by psychological experiments.However, the theoretical background of Sheldrake's hypotheses may also be relevant to forming hypotheses on a yet unknown physical principle, which are to explain the working of homeopathic potencies.

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Panda, S. R., A. Sahu, S. Das, A. K. Panda, and T. Sahu. "Doping-Dependent Nonlinear Electron Mobility in GaAs|In-=SUB=-x-=/SUB=-Ga-=SUB=-1-x-=/SUB=-As Coupled Quantum-Well Pseudo-Morphic MODFET Structure." Журнал технической физики 54, no. 7 (2020): 676. http://dx.doi.org/10.21883/ftp.2020.07.49509.8743.

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We analyze the asymmetric delta-doping dependence of nonlinear electron mobility μ of GaAs|InxGa1-xAs double quantum-well pseudo-morphic modulation doped field-effect transistor structure. We solve the Schrodinger and Poisson's equations self-consistently to obtain the sub-band energy levels and wave functions. We consider scatterings due to the ionized impurities (IMP), alloy disorder (AL), and interface roughness (IR) to calculate μ for a system having double sub-band occupancy, in which the inter-sub-band effects play an important role. Considering the doping concentrations in the barriers towards the substrate and surface sides as Nd1 and Nd2, respectively, we show that variation of Nd1 leads to a dip in μ near Nd1=Nd2, at which the resonance of the sub-band states occurs. A similar dip in μ as a function of Nd1 is also obtained at Nd1=Nd2 by keeping (Nd1+Nd2) unchanged. By increasing the central barrier width and well width, the dip in μ becomes sharp. We note that even though the overall μ is governed by the IMP- and AL-scatterings, the dip in μ is mostly affected through substantial variation of the sub-band mobilities due to IR-scattering near the resonance. Our results of nonlinear electron mobility near the resonance of sub-band states can be utilized for the performance analysis of GaAs|InGaAs pseudo-morphic quantum-well field-effect transistors. Keywords: asymmetric double quantum wells, GaAs|InxGa1-xAs structures, nonlinear electron mobility, pseudo-morphic HEMT structures, resonance of sub-band states.

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Sheldrake, Rupert. "Part I: Mind, memory, and archetype morphic resonance and the collective unconscious." Psychological Perspectives 18, no. 1 (March 1987): 9–25. http://dx.doi.org/10.1080/00332928708408747.

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Sheldrake, Rupert. "Society, spirit & ritual Morphic resonance and the collective unconscious part II." Psychological Perspectives 18, no. 2 (September 1987): 320–31. http://dx.doi.org/10.1080/00332928708410861.

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MISHKIND, MARC. "A Test for Morphic Resonance in Behavioural Responses to Multiple Choice Stimuli." Journal of Analytical Psychology 38, no. 3 (July 1993): 257–71. http://dx.doi.org/10.1111/j.1465-5922.1993.00257.x.

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van der Lei, Berend, Michel Cromheecke, and Stefan O. P. Hofer. "Mini Face Lift with Suspension Sutures: Historical Analysis of Development and Morphic Resonance." Plastic and Reconstructive Surgery 119, no. 7 (June 2007): 2317–19. http://dx.doi.org/10.1097/01.prs.0000261071.31701.5f.

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Tonnard, Patrick L., Alexis M. Verpaele, Koenraad Van Landuyt, and Moustapha Hamdi. "Mini Face Lift with Suspension Sutures: Historical Analysis of Development and Morphic Resonance." Plastic and Reconstructive Surgery 119, no. 7 (June 2007): 2319–20. http://dx.doi.org/10.1097/01.prs.0000261099.40156.4a.

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Brink, Nicholas E. "Book Reviews: The Presence of the Past: Morphic Resonance and the Habits of Nature." Imagination, Cognition and Personality 28, no. 3 (March 2009): 295–300. http://dx.doi.org/10.2190/1c.28.3.g.

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Robbins, Kimberly, and Chris A. Roe. "An Empirical Test of the Theory of Morphic Resonance by Using Recognition for Chinese Symbols." EXPLORE 6, no. 4 (July 2010): 256–62. http://dx.doi.org/10.1016/j.explore.2010.04.001.

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Ostrovskiy, Valeriy, Denis Butusov, Artur Karimov, and Valeriy Andreev. "DISCRETIZATION EFFECTS DURING NUMERICAL INVESTIGATION OF HODGKIN-HUXLEY NEURON MODEL." Bulletin of Bryansk state technical university 2019, no. 12 (December 19, 2019): 94–101. http://dx.doi.org/10.30987/1999-8775-2019-2019-12-94-101.

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Computer design is a valuable tool in the course of designing neuro-morphic systems. In particular it allows investigating basic mechanisms of neuron pulse activities in networks. For computer modeling it is necessary to digitize a continuous model of the system by means of the application of discrete operators able to keep basic properties of a prototype. But the accuracy of discrete models may decrease because of negative effects caused by the type of the method used, by a discretization pitch and errors in rounding off. This fact is significant for the analysis of non-linear systems to which belong the models of biological neurons. As a possible solution of the problem may be the development of specialized tools for the analysis of dynamic systems with the focus upon numerical methods used. In this paper by the example of the modeling of the neuron described by Hodgkin-Huxley classical equations there is considered a set of widespread methods for ODU solution. In the course of investigations there are shown possible negative consequences of incorrect use of some discrete operators. In the paper the results of two sets of computer experiments are presented. The first ones determine the limitations for the practical use of the methods of the first accuracy order during modeling neurons in the mode of resonance generation of action potentials. The second ones show discretization effects connected with chaotic modes of neurons functioning: incorrect behavior of discrete models which is manifested in the emergence of chaotic transition processes. The investigation results may be used at the formation of modeling tool packages both, non-linear dynamic systems in the whole, and neuro-morphic systems in particular.

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Łapiński, Jacek L. "Przestrzenio-czas i czaso-kultura. Uwagi o komplementarności przestrzeni, kultury, czasu i krajobrazu." Studia Ecologiae et Bioethicae 4, no. 1 (December 31, 2006): 61–75. http://dx.doi.org/10.21697/seb.2006.4.1.05.

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It is true to say that there is a wide range of definitions and types of space e.g. abstract space, mathematical space, physical space, social space, etc. Cultural depiction of space emphasizes its anthropological dimension. Cultural space is a sphere of social relations, interactions, and feedback between a human being and physical space. According to E.T. Hall, space is a form of communication. In my opinion, it is also the environment for the functioning of culture. Simultaneously, space seems to be a characteristic product of culture. Time is forming the organizations of cultural space. Time is a measure of change (Aristotle) a total of various rhythms, events, and conceptions (E.T. Hall). From an anthropological point of view, time is also a creator of different kinds of space environments for different kinds of culture. Cultural space and time complement one another. It appears that they should be perceived as space-time. As E.T. Hall claims, culture is a form of interpersonal communication. It is formed by any number of units and it reveals three levels of functioning:a) conscious, technical;b) private (or personal);c) hidden, unconscious, primary.The essential element shaping all levels of culture like in the case of space is time (e.g. biological, physical, metaphysical, sacred, cultural, etc.) Generally speaking, time is a silent language of culture - one of the basic means of communication. As Hall believes, time is a core system of every culture. As well as being the main organizer of a human being s cultural activity, time is a tool of insight into the culture. In my opinion, cultural research should take the modifying influence of time into consideration, these two factors ought to be treated inseparably as the reality of time-culture. Culture is a constituent of a cultural landscape. In my opinion, a cultural landscape is becoming a culture physiognomy an external reflection of its constituents: time, space, and communication. A cultural landscape is a manifestation of collective national remembrance which was inherited through generations, society, and ethnic groups. A cultural landscape evolves within the changes of remembrance, however remains strangely stable. Its changes occur with the delayed reactions. A hypothesis that explains the above characteristic features of a cultural landscape is one of Rupert Sheldrake's concept of the morphic field and morphic resonance.

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Bickel, Balthasar. "In the Vestibule of Meaning." Studies in Language 19, no. 1 (January 1, 1995): 73–127. http://dx.doi.org/10.1075/sl.19.1.04bic.

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In the Belhare (Tibeto-Burman) verb, morphotactics and allomorphy, but not morpheme semantics, are sensitive to a distinction between direct (1>2, 1>3, 2>3, 3SG>3) and inverse (3NS>3, 3>2, 3>1, 2>1) participant configurations. Comparison of this phenomenon with Cree (Algonquian) and rGya-ro (Tibeto-Burman) calls for a distinction of morphemic and sub- or supra-morphemic inversion. The difference is semiotically interpreted in a general theory of "Resonance Morphology". The smallest resonant pattern is either compositional and meaningful, i.e. a "morpheme", or predictable and meaningless, i.e. an "eideme". Eidemes can be motivationally grounded in an extra-morphological domain (e.g. pragmatics). This is demonstrated for morphotactics and allomorphy in Belhare and for a parallel in French.

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Allen, Jeffrey W., Kjersti A. Horais, Nicolle A. Tozier, Kirsten Wegner, Jacqueline A. Corbeil, Robert F. Mattrey, Steven S. Rossi, and Tony L. Yaksh. "Time Course and Role of Morphine Dose and Concentration in Intrathecal Granuloma Formation in Dogs." Anesthesiology 105, no. 3 (September 1, 2006): 581–89. http://dx.doi.org/10.1097/00000542-200609000-00024.

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Background Intrathecal morphine infusion leads to intrathecal granulomas. In dogs, the authors examined time course of granuloma formation and the role of concentration in granuloma development. Methods Dogs were prepared with lumbar intrathecal catheters and vest-mounted pumps. To define the time course of granuloma formation, serial magnetic resonance imaging was performed in animals receiving 10 or 31 days of morphine infusion (12.5 mg/ml at 40 microl/h). At these times, morphine was removed from the infusate, and further magnetic resonance images were acquired over 14-35 additional days. To assess dose versus concentration, dogs received 28-day infusions of vehicle, 12 mg morphine/day as 12.5 mg/ml at 40 microl/h, or 1.5 mg/ml at 334 microl/h (12 mg/day) for 28 days. Additional dogs received 3 mg/day as 12.5 mg/ml at 10 mul/h. Results Serial magnetic resonance images in dogs receiving morphine (12.5 mg/ml at 40 microl/h) revealed pericatheter-enhancing tissues as early as 3 days with a prominent signal by 10 days. Removal of morphine reduced the mass volume within 7 days. At a fixed infusion rate, the incidence of granuloma formation with the continuous intrathecal infusion of morphine ranged from 0 in vehicle-treated dogs to 100% in dogs treated with 12.5 mg/ml at 40 microl/h (12 mg/day). Infusion of 12 mg/day at 1.5 mg/ml (334 microl/h) resulted in granuloma in one of four animals. The authors found that infusion of morphine in different concentrations at a fixed rate resulted in a dose-dependent increase in concentration, with the granuloma-producing, dose-yielding lumbar cerebrospinal fluid morphine concentrations around 40 microg/ml. Conclusions Serial magnetic resonance imaging showed a rapid formation and regression of the masses initiated by intrathecal morphine infusion. These masses are dependent on local concentration.

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Ke, Haokun, Xianchao Du, Ling Wang, Xiao Wang, Jinsong Zhu, Yuan Gao, Bo Peng, Hongxia Hao, and Nengbin Cai. "Detection of morphine in urine based on a surface plasmon resonance imaging immunoassay." Analytical Methods 12, no. 23 (2020): 3038–44. http://dx.doi.org/10.1039/d0ay00648c.

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Stabler, Peter J., and Neil C. Bruce. "Oxidation of Morphine to 2,2′-Bimorphine byCylindrocarpon didymum." Applied and Environmental Microbiology 64, no. 10 (October 1, 1998): 4106–8. http://dx.doi.org/10.1128/aem.64.10.4106-4108.1998.

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ABSTRACT The oxidation of morphine by whole-cell suspensions and cell extracts of Cylindrocarpon didymum gave rise to the formation of 2,2′-bimorphine. The identity of 2,2′-bimorphine was confirmed by mass spectrometry and 1H nuclear magnetic resonance spectroscopy. C. didymum also displayed activity with the morphine analogs hydromorphone, 6-acetylmorphine, and dihydromorphine, but not codeine or diamorphine, suggesting that a phenolic group at C-3 is essential for activity.

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Chen, Chin-Mei, Yen-Yu I. Shih, Tiing-Yee Siow, Yun-Chen Chiang, Chen Chang, and Fu-Shan Jaw. "ANTINOCICEPTIVE EFFECT OF MORPHINE IN α-CHLORALOSE AND ISOFLURANE ANESTHETIZED RATS USING BOLD fMRI." Biomedical Engineering: Applications, Basis and Communications 20, no. 01 (February 2008): 39–46. http://dx.doi.org/10.4015/s1016237208000581.

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Blood oxygenation level dependent functional magnetic resonance imaging technique was used to explore the antinociceptive effect of morphine in the rat brain under α-chloralose and isoflurane anesthesia. Formalin was used as a pain-testing model which could produce significant activation in various brain areas. The results also showed that morphine pretreatment modulate neurovascular activities evoked by formalin stimulation, especially in cingulate cortex, somatosensory cortex, caudate putamen, visual cortex, and hippocampus. The present study identified the brain areas involved in modulating nociception.

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Stabler, Peter J., Peter J. Holt, and Neil C. Bruce. "Transformation of 2,2′-Bimorphine to the Novel Compounds 10-α-S-Monohydroxy-2,2′-Bimorphine and 10,10′-α,α′-S,S′-Dihydroxy-2,2′-Bimorphine byCylindrocarpon didymum." Applied and Environmental Microbiology 67, no. 8 (August 1, 2001): 3716–19. http://dx.doi.org/10.1128/aem.67.8.3716-3719.2001.

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ABSTRACT Whole-cell suspensions of Cylindrocarpon didymum were observed to transform 2,2′-bimorphine to the compounds 10-α-S-monohydroxy-2,2′-bimorphine and 10,10′-α,α′-S,S′-dihydroxy-2,2′-bimorphine. Mass spectrometry and 1H nuclear magnetic resonance spectroscopy confirmed the identities of these new morphine alkaloids.

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Zhuo, Guan-Yu, Ming-Chi Chen, Tzu-Yu Lin, Shih-Ting Lin, Daniel Tzu-Li Chen, and Cynthia Wei-Sheng Lee. "Opioid-Modulated Receptor Localization and Erk1/2 Phosphorylation in Cells Coexpressing μ-Opioid and Nociceptin Receptors." International Journal of Molecular Sciences 24, no. 2 (January 5, 2023): 1048. http://dx.doi.org/10.3390/ijms24021048.

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We attempted to examine the alterations elicited by opioids via coexpressed μ-opioid (MOP) and nociceptin/orphanin FQ (NOP) receptors for receptor localization and Erk1/2 (p44/42 MAPK) in human embryonic kidney (HEK) 293 cells. Through two-photon microscopy, the proximity of MOP and NOP receptors was verified by fluorescence resonance energy transfer (FRET), and morphine but not buprenorphine facilitated the process of MOP-NOP heterodimerization. Single-particle tracking (SPT) further revealed that morphine or buprenorphine hindered the movement of the MOP-NOP heterodimers. After exposure to morphine or buprenorphine, receptor localization on lipid rafts was detected by immunocytochemistry, and phosphorylation of Erk1/2 was determined by immunoblotting in HEK 293 cells expressing MOP, NOP, or MOP+NOP receptors. Colocalization of MOP and NOP on lipid rafts was enhanced by morphine but not buprenorphine. Morphine stimulated the phosphorylation of Erk1/2 with a similar potency in HEK 293 cells expressing MOP and MOP+NOP receptors, but buprenorphine appeared to activate Erk1/2 solely through NOP receptors. Our results suggest that opioids can fine-tune the cellular localization of opioid receptors and phosphorylation of Erk1/2 in MOP+NOP-expressing cells.

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Eitel, Ingo, Juan Wang, Thomas Stiermaier, Georg Fuernau, Hans-Josef Feistritzer, Alexander Joost, Alexander Jobs, et al. "Impact of Morphine Treatment on Infarct Size and Reperfusion Injury in Acute Reperfused ST-Elevation Myocardial Infarction." Journal of Clinical Medicine 9, no. 3 (March 9, 2020): 735. http://dx.doi.org/10.3390/jcm9030735.

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Current evidence regarding the effect of intravenous morphine administration on reperfusion injury and/or cardioprotection in patients with myocardial infarction is conflicting. The aim of this study was to evaluate the impact of morphine administration, on infarct size and reperfusion injury assessed by cardiac magnetic resonance imaging (CMR) in a large multicenter ST-elevation myocardial infarction (STEMI) population. In total, 734 STEMI patients reperfused by primary percutaneous coronary intervention <12 h after symptom onset underwent CMR imaging at eight centers for assessment of myocardial damage. Intravenous morphine administration was recorded in all patients. CMR was completed within one week after infarction using a standardized protocol. The clinical endpoint of the study was the occurrence of major adverse cardiac events (MACE) within 12 months after infarction. Intravenous morphine was administered in 61.8% (n = 454) of all patients. There were no differences in infarct size (17%LV, interquartile range [IQR] 8–25%LV versus 16%LV, IQR 8–26%LV, p = 0.67) and microvascular obstruction (p = 0.92) in patients with versus without morphine administration. In the subgroup of patients with early reperfusion within 120 min and reduced flow of the infarcted vessel (TIMI-flow ≤2 before PCI) morphine administration resulted in significantly smaller infarcts (12%LV, IQR 12–19 versus 19%LV, IQR 10–29, p = 0.035) and reduced microvascular obstruction (p = 0.003). Morphine administration had no effect on hard clinical endpoints (log-rank test p = 0.74) and was not an independent predictor of clinical outcome in Cox regression analysis. In our large multicenter CMR study, morphine administration did not have a negative effect on myocardial damage or clinical prognosis in acute reperfused STEMI. In patients, presenting early ( ≤120 min) morphine may have a cardioprotective effect as reflected by smaller infarcts; but this finding has to be assessed in further well-designed clinical studies

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Eisenach, James C., David D. Hood, Regina Curry, and Steven L. Shafer. "Cephalad Movement of Morphine and Fentanyl in Humans after Intrathecal Injection." Anesthesiology 99, no. 1 (July 1, 2003): 166–73. http://dx.doi.org/10.1097/00000542-200307000-00027.

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Background Despite decades of use, controversy remains regarding the extent and time course of cephalad spread of opioids in cerebrospinal fluid (CSF) after intrathecal injection. The purpose of this study was to examine differences between two often used opioids, morphine and fentanyl, in distribution in the CSF after intrathecal injection. Methods Eight healthy volunteers received intrathecal injection of morphine (50 microg) plus fentanyl (50 microg) at a lower lumbar interspace. CSF was sampled through a needle in an upper lumbar interspace for 60-120 min. At the end of this time, a sample was taken from the lower lumbar needle, and both needles were withdrawn. CSF volume was determined by magnetic resonance imaging. Pharmacokinetic modeling was performed with NONMEM. Results Morphine and fentanyl peaked in CSF at the cephalad needle at similar times (41 +/- 13 min for fentanyl, 57 +/- 12 min for morphine). The ratio of morphine to fentanyl in CSF at the cephalad needle increased with time, surpassing 2:1 by 36 min and 4:1 by 103 min. CSF concentrations did not correlate with weight, height, or lumbosacral CSF volume. The concentrations of morphine and fentanyl at both sampling sites were well described by a simple pharmacokinetic model. The individual model parameters did not correlate with the distance between the needles, CSF volume, patient height, or patient weight. Conclusions Fentanyl is cleared more rapidly from CSF than morphine, although their initial distribution in the first hour after injection does not differ greatly. The pharmacokinetic model demonstrates that mixing is the primary determinant of early concentrations and is highly variable among individuals.

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Shahidi-Dadras, Mohammad, Fahimeh Abdollahimajd, Razieh Jahangard, Ali Javinani, Amir Ashraf-Ganjouei, and Parviz Toossi. "Magnetic Resonance Imaging Evaluation in Patients with Linear Morphea Treated with Methotrexate and High-Dose Corticosteroid." Dermatology Research and Practice 2018 (July 2, 2018): 1–6. http://dx.doi.org/10.1155/2018/8391218.

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Background. Morphea is an inflammatory disease of the connective tissue that may lead to thickening and hardening of the skin due to fibrosis. The aim of this study was to document magnetic resonance imaging (MRI) changes in patients with linear morphea who were treated with methotrexate (MTX) and high-dose corticosteroid. Methods. This study was conducted on 33 patients from the outpatient’s dermatology clinic of our institute, who fulfilled the inclusion criteria. Patients received 15 mg/week of MTX and monthly pulses of methylprednisolone for three days in six months. The effectiveness of the treatment was evaluated by MRI, modified LS skin severity index (mLoSSI), and localized scleroderma damage index (LoSDI). Results. All parameters of mLoSSI and LoSDI including erythema, skin thickness, new lesion/lesion extension, dermal atrophy, subcutaneous atrophy, and dyspigmentation were also noticeably improved after treatment. Subcutaneous fat enhancement was the most common finding in MRI. MRI scores were significantly associated with clinical markers both before and after the treatment with the exception of skin thickness and new lesion/lesion extension which were not associated with MRI scores before and after the treatment, respectively. Limitations. The lack of correlative laboratory disease activity markers, control group, and clearly defined criteria to judge the MRI changes. Conclusion. MRI could be a promising tool for the assessment of musculoskeletal and dermal involvement and also monitoring treatment response in patients with morphea.

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Eddinger, Kelly A., Eric S. Rondon, Veronica I. Shubayev, Marjorie R. Grafe, Miriam Scadeng, Keith R. Hildebrand, Linda M. Page, Shelle A. Malkmus, Joanne J. Steinauer, and Tony L. Yaksh. "Intrathecal Catheterization and Drug Delivery in Guinea Pigs." Anesthesiology 125, no. 2 (August 1, 2016): 378–94. http://dx.doi.org/10.1097/aln.0000000000001166.

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Abstract Background Intrathecal infusion of opioids in dogs, sheep, and humans produces local space-occupying masses. To develop a small-animal model, the authors examined effects of intrathecal catheterization and morphine infusion in guinea pigs. Methods Under isoflurane, polyethylene or polyurethane catheters were advanced from the cisterna magna to the lumbar enlargement. Drugs were delivered as a bolus through the externalized catheter or continuously by subcutaneous minipumps. Hind paw withdrawal to a thermal stimulus was assessed. Spinal histopathology was systematically assessed in a blinded fashion. To assist in determining catheter placement, ex vivo images were obtained using magnetic resonance imaging in several animals. Canine spinal tissue from previous intrathecal morphine studies was analyzed in parallel. Results (1) Polyethylene (n = 30) and polyurethane (n = 25) catheters were implanted in the lumbar intrathecal space. (2) Bolus intrathecal morphine produced a dose-dependent (20 to 40 μg/10 μl) increase in thermal escape latencies. (3) Absent infusion, a catheter-associated distortion of the spinal cord and a fibrotic investment were noted along the catheter tract (polyethylene > polyurethane). (4) Intrathecal morphine infusion (25 mg/ml/0.5 μl/h for 14 days) resulted in intrathecal masses (fibroblasts, interspersed collagen, lymphocytes, and macrophages) arising from meninges proximal to the catheter tip in both polyethylene- and polyurethane-catheterized animals. This closely resembles mass histopathology from intrathecal morphine canine studies. Conclusions Continuous intrathecal infusion of morphine leads to pericatheter masses that morphologically resemble those observed in dogs and humans. This small-animal model may be useful for studying spinal drug toxicology in general and the biology of intrathecal granuloma formation in particular.

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Lowe, Andrew S., Steve C. R. Williams, Mark R. Symms, Ian P. Stolerman, and Mohammed Shoaib. "Functional Magnetic Resonance Neuroimaging of Drug Dependence: Naloxone-Precipitated Morphine Withdrawal." NeuroImage 17, no. 2 (October 2002): 902–10. http://dx.doi.org/10.1006/nimg.2002.1251.

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O'Brien, J. C., S. Goldman, and H. Jacobe. "628 Magnetic resonance imaging for assessment of disease activity in morphea." Journal of Investigative Dermatology 139, no. 5 (May 2019): S108. http://dx.doi.org/10.1016/j.jid.2019.03.704.

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Majid, D. S. Adnan, Sarah M. Burke, Amirhossein Manzouri, Teena D. Moody, Cecilia Dhejne, Jamie D. Feusner, and Ivanka Savic. "Neural Systems for Own-body Processing Align with Gender Identity Rather Than Birth-assigned Sex." Cerebral Cortex 30, no. 5 (December 9, 2019): 2897–909. http://dx.doi.org/10.1093/cercor/bhz282.

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Abstract Gender identity is a core aspect of self-identity and is usually congruent with birth-assigned sex and own body sex-perception. The neuronal circuits underlying gender identity are unknown, but greater awareness of transgenderism has sparked interest in studying these circuits. We did this by comparing brain activation and connectivity in transgender individuals (for whom gender identity and birth-assigned sex are incongruent) with that in cisgender controls (for whom they are congruent) when performing a body self-identification task during functional magnetic resonance imaging. Thirty transgender and 30 cisgender participants viewed images of their own bodies and bodies morphed in sex toward or opposite to birth-assigned sex, rating each image to the degree they identified with it. While controls identified with images of themselves, transgender individuals identified with images morphed “opposite” to their birth-assigned sex. After covarying out the effect of self-similarity ratings, both groups activated similar self- and body-processing systems when viewing bodies that aligned with their gender identity rather than birth-assigned sex. Additionally, transgender participants had greater limbic involvement when viewing ambiguous, androgynous images of themselves morphed toward their gender identity. These results shed light on underlying self-processing networks specific to gender identity and uncover additional involvement of emotional processing in transgender individuals.

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Chan, Michael, Kristopher Dennis, Yuexi Huang, Charles Mougenot, Edward Chow, Carlo DeAngelis, Jennifer Coccagna, et al. "Magnetic Resonance–Guided High-Intensity-Focused Ultrasound for Palliation of Painful Skeletal Metastases: A Pilot Study." Technology in Cancer Research & Treatment 16, no. 5 (August 1, 2016): 570–76. http://dx.doi.org/10.1177/1533034616658576.

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Background: Bone is one of the most common sites of metastases, with bone metastases-related pain representing a significant source of morbidity among patients with cancer. Magnetic resonance–guided focused ultrasound is a noninvasive, outpatient modality with the potential for treating painful bone metastases. The aim of this study is to report our initial experience with magnetic resonance–guided focused ultrasound in the treatment of bone metastases and our preliminary analysis of urinary cytokine levels after therapy. Methods: This was a single-center pilot study of 10 patients with metastatic cancer to investigate the feasibility of magnetic resonance–guided focused ultrasound for primary pain control in device-accessible skeletal metastases. Treatments were performed on a clinical magnetic resonance–guided focused ultrasound system using a volumetric ablation technique. Primary efficacy was assessed using Brief Pain Inventory scores and morphine equivalent daily dose intake at 3 time points: before, day 14, and day 30 after the magnetic resonance–guided focused ultrasound treatment. Urine cytokines were measured 3 days before treatment and 2 days after the treatment. Results: Of the 10 patients, 8 were followed up 14 days and 6 were followed up 30 days after the treatment. At day 14, 3 patients (37.5%) exhibited partial pain response and 4 patients (50%) exhibited an indeterminate response, and at day 30 after the treatment, 5 patients (83%) exhibited partial pain response. No treatment-related adverse events were recorded. Of the urine cytokines measured, only Transforming growth factor alpha (TGFα) demonstrated an overall decrease, with a trend toward statistical significance ( P = .078). Conclusion: Our study corroborates magnetic resonance–guided focused ultrasound as a feasible and safe modality as a primary, palliative treatment for painful bone metastases and contributes to the limited body of literature using magnetic resonance–guided focused ultrasound for this clinical indication.

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Arena, Andrea, and Walter Lacarbonara. "Piezoelectrically induced nonlinear resonances for dynamic morphing of lightweight panels." Journal of Sound and Vibration 498 (April 2021): 115951. http://dx.doi.org/10.1016/j.jsv.2021.115951.

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Sakai, Go, Kyoko Ogata, Taizo Uda, Norio Miura, and Noboru Yamazoe. "A surface plasmon resonance-based immunosensor for highly sensitive detection of morphine." Sensors and Actuators B: Chemical 49, no. 1-2 (June 1998): 5–12. http://dx.doi.org/10.1016/s0925-4005(98)00107-5.

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Mo, Yuan Heng, Po Chin Liang, Ming Chih Ho, Po Huang Lee, Fu Shan Jaw, and Steven Shinn-Forng Peng. "Morphine- and glucagon-augmented magnetic resonance cholangiopancreatography to evaluate living liver donors." Liver Transplantation 15, no. 9 (September 2009): 1021–27. http://dx.doi.org/10.1002/lt.21789.

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Hassenbusch, Samuel J., Prem K. Pillay, and Gene H. Barnett. "Radiofrequency Cingulotomy for Intractable Cancer Pain Using Stereotaxis Guided by Magnetic Resonance Imaging." Neurosurgery 27, no. 2 (August 1, 1990): 220–23. http://dx.doi.org/10.1227/00006123-199008000-00008.

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Abstract This study presents a new and simplified method of creating cingulate gyrus lesions by using stereotaxis guided by magnetic resonance imaging (MRI). Previous methods have utilized ventriculogram-guided stereotaxis requiring indirect cingulate gyrus localization and general anesthesia. With the present technique a BRW stereotactic frame was applied with the patient under local anesthesia. An MRI scan was performed using a T1 signal (TR, 600 ms; TE, 30 ms) in the coronal plane with 5-mm thick sections spaced every 6 mm. The coronal slice 24 mm posterior to the anterior tip of lateral ventricle was identified. The center of each (right and left) cingulate gyrus was identified as a target area, and appropriate coordinates were determined. Approach parameters were calculated for the right and left gyri using an azimuth of 45° and 315°, respectively, and a declination of 45°. A radiofrequency electrode was stereotactically placed so that the electrode tip was at a target point which was the center of the cingulate gyrus. A radiofrequency lesion (75°, 60 seconds) was made in each hemisphere's cingulate gyrus. Four patients with intractable terminal cancer pain have been initially treated in this manner. The lesions were well-localized on postoperative MRI scans. There have been no complications except for perilesional edema for 10 days in 1 patient (treated with longer radiofrequency settings that have subsequently been modified). Short-term pain relief in cancer patients was dramatic: morphine (intravenous 14 to 40 mg/h or oral 60 mg every 4 hours) preprocedure to oral oxycodone (1 to 2 tablets q4-6h) or oral morphine (4 to 8 mg every 4 to 6 hours) postprocedure. The use of MRI-guided stereotaxis to make cingulate gyrus lesions is an improvement that potentially allows the routine creation of these lesions as a standard cancer pain treatment. The technique is simple, uses local anesthesia, and appears to be effective and safe.

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Geng, Zhihai, Bolun Chen, Qiang Li, Xi Han, and Xuelian Zhu. "Efficacy of Morphine Combined with Mechanical Ventilation in the Treatment of Heart Failure with Cardiac Magnetic Resonance Imaging under Artificial Intelligence Algorithms." Contrast Media & Molecular Imaging 2022 (February 25, 2022): 1–9. http://dx.doi.org/10.1155/2022/1732915.

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This study was aimed at exploring the efficacy of morphine combined with mechanical ventilation in the treatment of heart failure with artificial intelligence algorithms. The cardiac magnetic resonance imaging (MRI) under the watershed segmentation algorithm was proposed, and the local grayscale clustering watershed (LGCW) model was designed in this study. A total of 136 patients with acute left heart failure were taken as the research objects and randomly divided into the control group (conventional treatment) and the experimental group (morphine combined with mechanical ventilation), with 68 cases in each group. The left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), N-terminal pro-brain natriuretic peptide (NT-proBNP), arterial partial pressure of oxygen (PaO2), and arterial partial pressure of carbon dioxide (PaCO2) were observed. The results showed that the mean absolute deviation (MAD) and maximum mean absolute deviation (max-MAD) of the LGCW model were lower than those of the fuzzy k-nearest neighbor (FKNN) algorithm and local gray-scale clustering model (LGSCm). The Dice metric was also significantly higher than that of other algorithms with statistically significant differences ( P < 0.05 ). After treatment, LVEDD, LVESD, and NT-proBNP of patients in the experimental group were significantly lower than those in the control group, and LVEF in the experimental group was higher than that in the control group ( P < 0.05 ). PaO2 of patients in the experimental group was also significantly higher than that in the control group ( P < 0.05 ). It suggested that the LGCW model had a better segmentation effect, and morphine combined with mechanical ventilation gave a better clinical efficacy in the treatment of acute left heart failure, improving the patients’ cardiac function and arterial blood gas effectively.

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Skuk, Verena G., and Stefan R. Schweinberger. "Influences of Fundamental Frequency, Formant Frequencies, Aperiodicity, and Spectrum Level on the Perception of Voice Gender." Journal of Speech, Language, and Hearing Research 57, no. 1 (February 2014): 285–96. http://dx.doi.org/10.1044/1092-4388(2013/12-0314).

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Purpose To determine the relative importance of acoustic parameters (fundamental frequency [F0], formant frequencies [FFs], aperiodicity, and spectrum level [SL]) on voice gender perception, the authors used a novel parameter-morphing approach that, unlike spectral envelope shifting, allows the application of nonuniform scale factors to transform formants and more direct comparison of parameter impact. Method In each of 2 experiments, 16 listeners with normal hearing (8 female, 8 male) classified voice gender for morphs between female and male speakers, using syllable tokens from 2 male–female speaker pairs. Morphs varied single acoustic parameters (Experiment 1) or selected combinations (Experiment 2), keeping residual parameters androgynous, as determined in a baseline experiment. Results The strongest cue related to gender perception was F0, followed by FF and SL. Aperiodicity did not systematically influence gender perception. Morphing F0 and FF in conjunction produced convincing changes in perceived gender—changes that were equivalent to those for Full morphs interpolating all parameters. Despite the importance of F0, morphing FF and SL in combination produced effective changes in voice gender perception. Conclusions The most important single parameters for gender perception are, in order, F0, FF, and SL. At the same time, F0 and vocal tract resonances have a comparable impact on voice gender perception.

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Datta, Y. "How Christianity, Western Science & Technology Exploited Nature in America: Birth of the Environmental Movement." Journal of Economics and Public Finance 8, no. 1 (February 28, 2022): p65. http://dx.doi.org/10.22158/jepf.v8n1p65.

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The objective of this paper is to understand why the Western civilization had exploited nature so much that its own quality of life--even its survival--was now at stake. The answer is: the Judeo-Christian tradition.A central belief of the Judeo-Christian theology has been dualism—that man is separate from nature—and anthropocentrism: that man is the master and the center of this universe, with a license to exploit nature.Christianity prospered in the great cities of the time which were--like today--the centers of economic and cultural attraction. Therefore, a concentration of population in urban areas must have exerted a deep influence over the entire character of Christianity.Victory of Christianity over paganism was the greatest psychic revolution in the history of the Western culture.Pre-Christian cultures believed in animism: that every part of the environment--living and non-living—had a consciousness. By destroying pagan animism, Christianity made it possible to exploit nature in a mood of indifference to the feelings of natural objects. Severed from the human community and its ethical protection, nature was fully exposed to human greed. The whole concept of the sacred grove is alien to Christianity and to the ethos of the West. For nearly two millennia Christian missionaries have been chopping down sacred groves, based on the idea that they are idolatrous because they assume spirit in nature.St. Francis was the greatest spiritual revolutionary in Western history since Christ. He preached the notion of equality of all creatures—including man—in opposition to the idea of man’s unlimited rule over nature sanctioned by Christian theology. Unfortunately, he failed.Aristotle’s scientific philosophy of nature—animate and alive—dominated Western thought for two thousand years after his death. However, thanks to the Scientific Revolution, a radical change occurred in scientific thought during the 16th and 17th centuries. As a result, this medieval worldview went through a fundamental change. The notion of an organic and spiritual universe was replaced by that of the world as a machine, and the word machine became a dominant metaphor of the modern era. Around 1850, Western Europe and North America arranged a marriage between science and technology that signified the Baconian creed of power over nature. Its acceptance as a normal pattern of action may mark the greatest event in human history since the invention of agriculture.While the Transcontinental Railroad connected East and West, yet, in its wake, lives of countless Native Americans were destroyed. In addition, tens of million buffalos were almost driven to extinction.Pre-Christian societies believed that every part of the natural environment had a consciousness or spirit. The work of Suzanne Simard provides an excellent real-world example of the veracity of such belief. Her research shows that forests have a social life, and that trees talk to each other.Sheldrake, based on his controversial theory of Morphic Resonance, says that natural systems inherit a collective memory from all previous things of their kind, no matter how faraway they were, nor how long ago they existed. The Scientific Revolution’s theory of reductionism encourages an atomistic and disintegrated view of nature. However, Nature is through and through relational, and interference at one point, has interminable and unforeseeable results on the other.The first occupants of North America—the Native Americans--were better custodians of the ecosystem than the subsequent tenants. Native Americans considered the rights of animals, plants—and even rocks—as sacred.America is a leader in the creation of national parks and wilderness areas, and has served as a model for countries around the world. Eastern religions--e.g., Hinduism, Buddhism, Taoism, and Zen Buddhism—totally reject the dualism and anthropocentrism of Christianity. By advocating the submersion of the human self in a larger organic whole, they cleared the intellectual way for environmental ethics.An extraordinary transformation has taken place in America: one that has replaced fear and hatred of wilderness in the past, to appreciation—and even reverence.Wilderness is not so much a place, but rather as a feeling about a place: a perceived reality, and a state of mind.The image of the earth as Mother is found in traditional cultures all over the world. So, we feel uncomfortable when we realize that we are polluting our own Mother.Finally, astronomer Carl Sagan--and 22 other well-known researchers--issued an appeal in 1990. Their message was: The “efforts to safeguard and cherish the environment need to be infused with a vision of the sacred.”

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Huo, Xianxu, Ke Xu, Ruixin Liu, Xi Chen, Zhanchun Li, and Haiyun Yan. "A Structure-Reconfigurable Soft-Switching DC-DC Converter for Wide-Range Applications." Energies 12, no. 15 (July 28, 2019): 2905. http://dx.doi.org/10.3390/en12152905.

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In this paper, a structure-reconfigurable resonant DC-DC (direct current – direct current) converter is presented. By controlling the state of the auxiliary switch, the converter could change the resonant structure to acquire a high efficiency and wide voltage gain range simultaneously. The characteristics of the LLC (inductor-inductor-capacitor) resonant converter are firstly analyzed. Based on this, through introducing additional resonant elements and adopting the topology morphing method, the proposed converter can be formed. Moreover, a novel parameter selection method is discussed to satisfy both working states. Then, a detailed loss analysis calculation is conducted to determine the optimal switching point. In addition, an extra resonant zero point is generated by the topology itself, and the inherent over-current protection is guaranteed. Finally, a 500 W prototype is built to demonstrate the theoretical rationality. The output voltage is constant at 400 V even if the input voltage varies from 160 to 400 V. A peak efficiency of 97.2% is achieved.

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Miura, Norio, Kyoko Ogata, Go Sakai, Taizo Uda, and Noboru Yamazoe. "Detection of Morphine in ppb Range by Using SPR (Surface- Plasmon-Resonance) Immunosensor." Chemistry Letters 26, no. 8 (August 1997): 713–14. http://dx.doi.org/10.1246/cl.1997.713.

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Ossenkopp, Klaus-Peter, Martin Kavaliers, Frank S. Prato, G. Campbell Teskey, Edmund Sestini, and Maurice Hirst. "Exposure to nuclear magnetic resonance imaging procedure attenuates morphine-induced analgesia in mice." Life Sciences 37, no. 16 (October 1985): 1507–14. http://dx.doi.org/10.1016/0024-3205(85)90182-1.

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Hashmi, A., and B. Epureanu. "Sensitivity Resonance and Attractor Morphing Quantified by Sensitivity Vector Fields for Parameter Reconstruction." Nonlinear Dynamics 45, no. 3-4 (June 14, 2006): 319–35. http://dx.doi.org/10.1007/s11071-005-9009-5.

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Neville, George A., Irena Ekiel, and Ian C. P. Smith. "High-resolution proton magnetic resonance spectra of morphine and its threeO-acetyl derivatives." Magnetic Resonance in Chemistry 25, no. 1 (January 1987): 31–35. http://dx.doi.org/10.1002/mrc.1260250108.

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Sindhwani, Nikhil, Geertje Callewaert, Thomas Deprest, Susanne Housmans, Dirk Van Beckevoort, and Jan Deprest. "Short term post-operative morphing of sacrocolpopexy mesh measured by magnetic resonance imaging." Journal of the Mechanical Behavior of Biomedical Materials 80 (April 2018): 269–76. http://dx.doi.org/10.1016/j.jmbbm.2018.02.012.

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Bliss, Thomas K., Tetsuya Iwasaki, and Hilary Bart-Smith. "CPG Control of a Tensegrity Morphing Structure for Biomimetic Applications." Advances in Science and Technology 58 (September 2008): 137–42. http://dx.doi.org/10.4028/www.scientific.net/ast.58.137.

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Rhythmic movements associated with animal locomotion are controlled by neuronal circuits known as central pattern generators (CPG). These biological control systems appear to entrain to the natural frequencies of the mechanical systems they control, taking advantage of the resonance of the structure, resulting in efficient control. The ultimate goal is employing these controls in a biomimetic autonomous underwater vehicle so as to capture, and possibly improve upon, the performance capabilities of animals like the manta ray. To this end, this paper investigates the CPG control of a simple tensegrity structure. The dynamics of a tensegrity structure are linearized about a nominal configuration, and a synthesized CPG is used as the control input. Successful integration is shown by the CPG's ability to tune the structure's first mode.

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Guo, Xiangying, Yang Zhang, Wei Zhang, Lin Sun, and Shuping Chen. "Nonlinear Dynamics of Z-Shaped Folding Wings with 1:1 Inner Resonance." International Journal of Bifurcation and Chaos 27, no. 08 (July 2017): 1750124. http://dx.doi.org/10.1142/s0218127417501243.

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Predicting the nonlinear vibration responses of a Z-shaped folding wing during the morphing process is a prerequisite for structural design analysis. Therefore, the present study focuses on the nonlinear dynamical characteristics of a Z-shaped folding wing. The folding wing is divided into three carbon fiber composite plates connected by rigid hinges. The nonlinear dynamic equations of the system are derived using Hamilton’s principle based on the von Kármán equations and classical laminate plate theory. The mode shape functions of the system are then obtained using finite element analysis. Galerkin’s approach is employed to discretize the partial differential governing equations into a two-degree-of-freedom nonlinear system. The case of 1:1 inner resonance is considered. The method of multiple scales is employed to obtain the averaged equations of the system. Finally, numerical simulation is performed to investigate the nonlinear dynamical characteristics of the system. Bifurcation diagrams and wave-form diagrams illustrate the different motions of the Z-shaped folding wing, including periodic and chaotic motions under given conditions. The influence of transverse excitations on the bifurcations and chaotic motion of the Z-shaped folding wing is investigated numerically.

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Hao, Hong Xia, Hong Zhou, Jing Chang, Jun Zhu, and Tian Xin Wei. "Molecularly imprinted polymers for highly sensitive detection of morphine using surface plasmon resonance spectroscopy." Chinese Chemical Letters 22, no. 4 (April 2011): 477–80. http://dx.doi.org/10.1016/j.cclet.2010.11.004.

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Lin, Bor-Ren. "Bidirectional Resonant Converter for DC Microgrid Applications." Processes 9, no. 9 (September 15, 2021): 1664. http://dx.doi.org/10.3390/pr9091664.

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A bidirectional resonant converter is presented and verified in this paper for an electric vehicle battery charger/discharger system. The presented circuit can achieve forward and backward power operation, low switching losses on active devices, and wide output voltage operation. The circuit structure of the presented converter includes two resonant circuits on the primary and secondary sides of an isolated transformer. The frequency modulation approach is adopted to control the studied circuit. Owing to the resonant circuit characteristic, active devices for both forward (battery charge) and backward (battery discharge) power operation can be turned on at zero voltage switching. In order to implement a universal battery charger for different kinds of electric vehicle applications, the DC converter is demanded to have a wide output voltage range capability. The topology morphing between a full bridge resonant circuit and half bridge resonant circuit is selected to obtain high- and low-output voltage range operations so that the 200–500 V output voltage range is realized in the presented resonant converter. Compared to the conventional bidirectional converters, the proposed can be operated under a wide voltage range operation. In the end, a 1 kW laboratory prototype circuit is built, and experiments are provided to demonstrate the validity and performance of the presented bidirectional resonant converter.

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Lee, Andrew J., and Daniel J. Inman. "A multifunctional bistable laminate: Snap-through morphing enabled by broadband energy harvesting." Journal of Intelligent Material Systems and Structures 29, no. 11 (May 7, 2018): 2528–43. http://dx.doi.org/10.1177/1045389x18770895.

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The elastic instabilities associated with buckling in bistable structures have been harnessed toward energy-based and motion-based applications, with significant research toward energy harvesting and morphing. Often combined with smart materials, structural prototypes are designed with a single application in mind. Recently, a novel method of inducing bistability was proposed by bonding two piezoelectrically actuated macro fiber composites in a [Formula: see text] layup and releasing the voltage post cure to yield two cylindrically stable configurations. Since the macro fiber composites are simultaneously the actuator and host structure, the resulting efficiencies enable this bistable laminate to be multifunctional, with both broadband energy harvesting and snap-through morphing capabilities. This article experimentally characterizes the vibration-based energy harvesting performance of the laminate to enable morphing. Through frequency sweeps across the first two modes of both states, the laminate exhibits broadband cross-well dynamics that are exploited for improved power generation over linear resonant harvesters. Besides single-well oscillations, snap-throughs are observed in intermittencies and subharmonic, chaotic, and limit cycle oscillations. The maximum power output of each regime and their charge durations of an energy harvesting module are assessed. The laminate’s capabilities are then bridged by utilizing harvested energy in the charged module to initiate snap-through actuation.

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Hyder, Fahmeed, Richard P. Kennan, Ikuhiro Kida, Graeme F. Mason, Kevin L. Behar, and Douglas Rothman. "Dependence of Oxygen Delivery on Blood Flow in Rat Brain: A 7 Tesla Nuclear Magnetic Resonance Study." Journal of Cerebral Blood Flow & Metabolism 20, no. 3 (March 2000): 485–98. http://dx.doi.org/10.1097/00004647-200003000-00007.

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Magnetic resonance imaging (MRI) and spectroscopy (MRS) were used at a magnetic field strength of 7 T to measure CBF and CMRO2 in the sensorimotor cortex of mature rats at different levels of cortical activity. In rats maintained on morphine anesthesia, transitions to lower activity and higher activity states were produced by administration of pentobarbital and nicotine, respectively. Under basal conditions of morphine sulfate anesthesia, CBF was 0.75 ± 0.09 mL · g−1 · min−1 and CMRO2 was 3.15 ± 0.18 μmol · g−1 · min−1. Administration of sodium pentobarbital reduced CBF and CMRO2 by 66% ± 16% and 61% ± 6%, respectively (i.e., “deactivation”). In contrast, administration of nicotine hydrogen tartrate increased CBF and CMRO2 by 41% ± 5% and 30% ± 3%, respectively (i.e., “activation”). The resting values of CBF and CMRO2 for α-chloralose anesthetized rats were 0.40 ± 0.09 mL · g−1 · min−1 and 1.51 ± 0.06 μmol · g−1 · min−1, respectively. Upon forepaw stimulation, CBF and CMRO2 were focally increased by 34% ± 10% and 26% ± 12%, respectively, above the resting nonanesthetized values (i.e., “activation”). Incremental changes in CBF and CMRO2, when expressed as a percentage change for “deactivation” and “activation” from the respective control conditions, were linear (R2 = 0.997) over the entire range examined with the global and local perturbations. This tight correlation for cerebral oxygen delivery in vivo is supported by a recent model where the consequence of a changing effective diffusivity of the capillary bed for oxygen, D, has been hypothetically shown to be linked to alterations in CMRO2 and CBF. This assumed functional characteristic of the capillary bed can be theoretically assessed by the ratio of fractional changes in D with respect to changes in CBF, signified by Ω. A value 0.81 ± 0.23 was calculated for Ω with the in vivo data presented here, which in turn corresponds to a supposition that the effective oxygen diffusivity of the capillary bed is not constant but presumably varies to meet local requirements in oxygen demand in a similar manner with both “deactivation” and “activation.”

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Song, Yihao, and Yanfeng Shen. "Highly morphing and reconfigurable fluid–solid interactive metamaterials for tunable ultrasonic guided wave control." Applied Physics Letters 121, no. 26 (December 26, 2022): 264102. http://dx.doi.org/10.1063/5.0117634.

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Fluid–structural interactions enable the alternation of local resonance behaviors of elastic metamaterial unit cells. Magnetically active ferrofluids facilitate reconfiguration couplings for breaking and tunneling ultrasonic wave energy transmission. This Letter presents a magnetic fluid–solid interactive metamaterial to achieve the tunable manipulation of multimodal, dispersive ultrasonic guided waves. It is revealed that the phenomenon of the fluid–structure interaction plays an indispensable role in the achievement of bandgap formation and translation. The tunable mechanism stems from the variation of the fluid–solid coupling reconfiguration arising from liquid morphing via electromagnetic stimuli. The tunable wave control performance was explicitly validated through both numerical simulations and experimental verifications. Such an active metamaterial system may possess application potential for future highly flexible and tunable wave control, e.g., selective-tunnel waveguiding and adaptive mechanical frequency filtering.

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Hama, Aldric, Takahiro Natsume, Shin`ya Ogawa, Yuji Awaga, Ikuo Hayashi, Akihisa Matsuda, and Hiroyuki Takamatsu. "Pain-Related Behavior and Brain Activation in a Cynomolgus Macaque Model of Postoperative Pain." CNS & Neurological Disorders - Drug Targets 17, no. 5 (August 7, 2018): 348–60. http://dx.doi.org/10.2174/1871527317666180515121350.

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Background: Inadequate postoperative pain management could lead to persistent pain and this is, in part, due to incomplete understanding of the mechanism of postoperative pain. Currently available rodent models may have limited translatability to clinical postoperative pain. Thus, a preclinical model of postoperative pain was developed in the cynomolgus macaque, a species that is phylogenetically closer to humans than rodents. Method: The presence of pressure hypersensitivity was assessed with non-noxious pressure applied proximally and distally (approximately 10 cm) to an abdominal incision in macaques. The effect of the opioid morphine (intramuscular, i.m.), the nonsteroidal anti-inflammatory drug diclofenac (i.m.) and the anticonvulsant pregabalin (i.m.) on pressure hypersensitivity was evaluated one and two days following surgery. Brain activation during non-noxious pressure stimulation was observed with functional magnetic resonance imaging. Results: Hypersensitivity to non-noxious pressure applied proximally and distally (approximately 10 cm) to the incision was observed, lasting for up to seven days and three days, respectively, following surgery. Postoperative pressure hypersensitivity was attenuated with morphine but not with either diclofenac or pregabalin. Bilateral activation of the insular cortex and cingulate cortex was observed during non-noxious pressure stimulation proximal to the incision, which was attenuated with morphine. By contrast, pregabalin reduced only cingulate cortex activation. Conclusion: The lack of antinociceptive efficacy of pregabalin on postoperative pain could be due to the incomplete suppression of pressure-evoked brain activation. It is speculated that incomplete postoperative pain relief observed in general could be due to residual or persistent activity of key pain nuclei such as the insular cortex. The current macaque model could be used for further elaborating the mechanism of postoperative pain as well as confirming the efficacy of potential treatments for the management of postoperative pain.

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Romañuk, Carolina B., Yamila Garro-Linck, M. Silmara Alves de Santana, Ruben H. Manzo, Alejandro P. Ayala, Gustavo A. Monti, Ana K. Chattah, and Maria E. Olivera. "Application of 1-Dimensional and 2-Dimensional Solid-State Nuclear Magnetic Resonance Spectroscopy to the Characterization of Morphine, Morphine Hydrochloride, and Their Hydrates." Journal of Pharmaceutical Sciences 106, no. 10 (October 2017): 3033–40. http://dx.doi.org/10.1016/j.xphs.2017.05.021.

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Dillon, Paul P., Stephen J. Daly, Bernadette M. Manning, and Richard O'Kennedy. "Immunoassay for the determination of morphine-3-glucuronide using a surface plasmon resonance-based biosensor." Biosensors and Bioelectronics 18, no. 2-3 (March 2003): 217–27. http://dx.doi.org/10.1016/s0956-5663(02)00182-3.

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Journal articles on the topic 'Morphic Resonance'

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