Academic literature on the topic 'Moonta mines'

Photo by Robina Weermeijer on Unsplash INTRODUCTION Geographic inequities in access to donor lungs have persisted since the first successful lung transplant in 1983.[1] With unanswered questions regarding organ preservation and transport in the early days of transplantation, the United Network of Organ Sharing (UNOS) understandably incorporated geography in the allocation algorithm. Today, geography is still the most influential criterion in the lung allocation algorithm.[2] As a result, patients in urban centers often receive transplants before patients in less-resourced rural areas. Ex vivo machine perfusion can significantly improve lung procurement and transport, offering longer preservation times before, after, or during transportation. Out-of-hospital perfusion centers, a recent addition to the healthcare field, may increase both the number of lungs available and potentially the distance they can travel. Before the adoption of machine perfusion becomes commonplace, UNOS should direct how to integrate machine perfusion into procurement networks best and shed the antiquated geographical confines that govern allocation today and compromise the ethical standards on which the field was founded. ANALYSIS l. The Past: A History of Geographic Disparities in Lung Transplantation Since the founding of UNOS in 1986, patient geography has been the first filter for all lung procurements. In the early days of the field, implementing these so-called donor service areas, while arbitrarily formed, made sense given the unknowns pertaining to lung preservation and transportation. For almost two decades, donor service areas and time on the waitlist governed lung allocation. In 1998, after physician protest and advocacy, the U.S. Department of Health and Human Services (HHS) delivered the Final Rule on Organ Transplantation to create a more equitable organ allocation system. Even then, it was not until 2005 that UNOS developed the lung allocation score, a quantitative metric that considered predicted waitlist survival and transplant benefit. The implementation of the lung allocation score in the U.S. and abroad by Eurotransplant was a success by multiple standards, most importantly reducing waitlist mortality to record lows.[3] However, a glaring problem remained: the donor service area criterion remained, and arbitrary geographical boundaries continued to govern the distribution of all procured lungs. Despite the improvements in waitlist mortality, regions with low rates of lung donation, primarily rural areas, have suffered disproportionately. Areas in the lowest quartile of lung availability had an 84 percent increased risk of waitlist death and a 57 percent lower transplantation rate than the top quartile.[4] In fact, simply moving to an adjacent donor service area a few miles away might double a patient’s chances of receiving a lung transplant, significantly more than that patient being bumped into a higher lung allocation score bracket.[5] That is, driving across an arbitrary border might increase one’s chances of receiving a new set of lungs. Unsurprisingly, analysis of data over the last decade shows that donor service areas are independently associated with disparities in access to lung transplants significantly more than any other factor, including gender, ethnicity, diagnosis group, or age. ll. The Future: Machine Perfusion and Equity in Organ Allocation Farther allocation distances are associated with sharper drops in waitlist mortality. A model from Stanford University demonstrates that expanding the existing 250-mile threshold to a 500-mile threshold would decrease waitlist mortality by 21.3 percent; an expansion of 1000 miles would lower it by 31.8 percent.[6] Since lungs are already more delicate than other solid organs,[7] an expansion would require better and longer preservation. The answer is already here: machine perfusion. Ex vivo machine perfusion of organs prior to transplantation has grown remarkably over the past two decades, with recent clinical trial results demonstrating the ability of machine perfusion to resuscitate and assess “marginal” organs prior to transplantation.[8] Many centers around the U.S. already apply machine perfusion to expand the donor pool, and the adoption of machine perfusion as common practice is burgeoning. While the availability of more organs will decrease waiting list mortality, it alone will not address the longstanding geographical disparities. In fact, unless there is deliberate preparation by UNOS, this new biotechnology could very easily exacerbate geographic disparities. It is currently an expensive technology that is exclusive to urban centers with an already high organ availability. Proper foresight before widespread adoption is critical. As machine perfusion will extend the preservation of all solid organs, discussions must start taking place now regarding larger allocation boundaries or even a boundless system altogether. One concern is that organs resuscitated in this manner will have lower efficacy than organs preserved on ice and rapidly transplanted. Yet, a recent retrospective study from the Toronto group showed that longer perfusion times over 12 hours do not impact patient outcomes,[9] and some groups have had success with preservation times over 20 hours.[10] In addition to longer preservation times, machine perfusion can easily be made portable. Data from a recent international pivotal trial using the Organ Care System (OCS) from the Massachusetts-based company TransMedics showed the promising ability of portable machine perfusion to preserve and resuscitate marginal lungs. Indeed, while much of the attention around machine perfusion has been about its capability to resuscitate marginal organs, its secondary ability, allowing farther transport of lungs, could end geographic disparities in organ allocation. Before it is universally adopted into clinical practice, it is imperative that UNOS acts now to direct hospitals on how to integrate machine perfusion into procurement networks. There also must be preemptive policies regarding out-of-hospital perfusion centers. The first and only example thus far is the private corporation Lung Bioengineering, located in Silver Spring, Maryland. This standalone center aims to resuscitate and analyze declined lungs via machine perfusion, shipping viable ones to nearby U.S. transplant centers. The company is currently finishing a phase 2 clinical trial assessing the safety of extending lung preservation times with it. Unless decisive action is taken now, these centers will continue to open exclusively in urban areas surrounded by high-volume centers. To engage in the UNOS organ allocation system, private corporations should be required to distribute to rural and previously under-resourced areas. This could be accomplished by setting up satellite campuses or investing in the necessary infrastructure to preserve and deliver organs far distances portably. CONCLUSION We finally have the tools to extinguish the perennial problem of geographic disparities in organ allocation. Within the next five to ten years, there will be widespread adoption of machine perfusion, both in hospitals and in out-of-hospital perfusion centers. In an already convoluted organ allocation system, it will further complicate organ allocation and will potentially worsen disparities if action is not taken upfront. Establishing regulations to ensure machine perfusion is leveraged in a way that is equitable to all who need solid organ transplants, not only those who live within 250 miles of transplant centers, is crucial. It is necessary for UNOS to be ahead of the curve, mitigate these potential consequences, and reprioritize the ethical principles on which the field was founded. This example should serve as a model for how biotechnology can ameliorate disparities – geographic or otherwise – in scarce resource allocation in healthcare. [1] Lynch, R. J., and R. E. Patzer. 2019. "Geographic inequity in transplant access." Curr Opin Organ Transplant 24 (3): 337-342. https://doi.org/10.1097/MOT.0000000000000643. [2] Goff, R. R., E. D. Lease, S. Sweet, A. Robinson, and D. Stewart. 2020. “Measuring and Monitoring Equity in Access to Deceased Donor Lung Transplants among Waitlisted Candidates.” J Hear Lung Transplant 39 (4): S216. https://doi.org/10.1016/j.healun.2020.01.847. [3] Egan, T. M. 2018. "From 6 years to 5 days for organ allocation policy change." J Heart Lung Transplant 37 (5): 675-677. https://doi.org/10.1016/j.healun.2017.12.010. [4] Benvenuto, L. J., D. R. Anderson, H. P. Kim, J. L. Hook, L. Shah, H. Y. Robbins, F. D'Ovidio, M. Bacchetta, J. R. Sonett, S. M. Arcasoy, and Program From the Columbia University Lung Transplant. 2018. "Geographic disparities in donor lung supply and lung transplant waitlist outcomes: A cohort study." Am J Transplant 18 (6): 1471-1480. https://doi.org/10.1111/ajt.14630. [5] Kosztowski, M., S. Zhou, E. Bush, R. S. Higgins, D. L. Segev, and S. E. Gentry. 2019. "Geographic disparities in lung transplant rates." Am J Transplant 19 (5): 1491-1497. https://doi.org/10.1111/ajt.15182. [6] Mooney, J. J., J. Bhattacharya, and G. S. Dhillon. 2019. "Effect of broader geographic sharing of donor lungs on lung transplant waitlist outcomes." J Heart Lung Transplant 38 (2): 136-144. https://doi.org/10.1016/j.healun.2018.09.007. [7] Possoz, J., A. Neyrinck, and D. Van Raemdonck. 2019. "Ex vivo lung perfusion prior to transplantation: an overview of current clinical practice worldwide." J Thorac Dis 11 (4): 1635-1650. https://doi.org/10.21037/jtd.2019.04.33. [8] Noah, C. V., P. Tratnig-frankl, S. Raigani, C. Cetrulo, K. Uygun, and H. Yeh. 2020. “Moving the Margins: Updates on the Renaissance in Machine Perfusion for Organ Transplantation.” Curr Transplant Reports 7 (2): 1-10. https://doi.org/10.1007/s40472-020-00277-z. [9] Yeung, J. C., T. Krueger, K. Yasufuku, M. de Perrot, A. F. Pierre, T. K. Waddell, L. G. Singer, S. Keshavjee, and M. Cypel. 2017. "Outcomes after transplantation of lungs preserved for more than 12 h: a retrospective study." Lancet Respir Med 5 (2): 119-124. https://doi.org/10.1016/S2213-2600(16)30323-X. [10] Cypel, M., A. Neyrinck, and T. N. Machuca. 2019. "Ex vivo perfusion techniques: state of the art and potential applications." Intensive Care Med 45 (3): 354-356. https://doi.org/10.1007/s00134-019-05568-3.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
Celestial objects
Objetos celestes como a Lua e o Sol bloqueiam os raios cósmicos que vem de suas direções para a Terra, produzindo um défcit chamado de sombra. A medida deste défcit possibilita a determinação da resolução angular e do alinhamento de detectores de raios cósmicos, o estudo dos campos magnéticos terrestre, solar e interplanetário e a determinação da razão antipróton/próton na escala de energia TeV. Vários experimentos já observaram a sombra de raios cósmicos da Lua e/ou do Sol com o objetivo de calibrar seus detectores. Descrevemos neste trabalho o experimento MINOS e seus resultados da sombra da Lua e do Sol. Simulamos a sombra da Lua levando em conta seu movimento no céu e, para tanto, de nimos e testamos métodos de simulação e diferentes composições para os raios cósmicos. Também avaliamos várias proporções para antiprótons no fluxo de raios cósmicos a m de comparar com os resultados do experimento MINOS e conjecturar uma possível razão p=p para os dados observados. Ambos os métodos que de nimos, método do dé cit e da fonte de raios cósmicos, permitiram uma análise qualitativa da sombra. No entanto, só foi possível realizar uma análise quantitativa na simulação tendo a Lua como um défcit. Dessa forma, adotamos este método para as simulações subsequentes. Notamos algumas diferenças para as sombras obtidas usando próton e núcleo de hélio como partículas primárias de raios cósmicos. Todavia, a sombra encontrada combinando prótons (90%) e núcleos de hélio (10%) foi semelhante à sombra obtida apenas para prótons. Na simulação incluindo o movimento da Lua, avaliamos os efeitos do campo geomagnético na partícula primária, desde a Lua até a atmosfera terrestre, e nos múons (partícula secundária) desde sua produção até o nível do mar. Como esperado, obtivemos uma sombra da Lua mais similar com os resultados do experimento MINOS ao incluir a de exão tanto das partículas primárias dos raios cósmicos quanto das partículas do chuveiro do que considerando apenas o desvio destas últimas. Nossa simulação foi capaz de reproduzir a sombra provocada pela Lua com a localização do maior dé cit comparável àquela encontrada pelo experimento MINOS. Entretanto, ainda acrescentamos núcleos de hélio e antiprótons na simulação incluindo o movimento da Lua com o objetivo de melhorar o resultado. Obtivemos um défcit localizado o mais próximo possível do obtido pelo experimento MINOS usando a proporção p=p = 0;45. Tal resultado deve ser melhor estudado e a simulação aprimorada para que se determine esta razão entre antiprótons e prótons com a precisão adequada.

Watching a Partial Eclipse Which way does the eclipse travel? Relative to Earth, the Moon and Sun are moving at slightly different speeds, which means the Moon’s shadow sweeps across the Earth’s surface from west to east at about 2000 miles an hour, a...

Using chemical and nuclear electric propulsion for the exploration of the Martian moons will be investigated. Both oxygen/hydrogen chemical propulsion and nuclear electric propulsion with 500 kilowatt electric (kWe) to 10 megawatt electric (MWe) reactors will be assessed. The initial masses, propellant masses, and trip times for a variety of space vehicle payload masses will be compared. For high energy orbital transfer, the nuclear electric propulsion vehicles required a small fraction of the propellant mass over oxygen/hydrogen orbital transfer vehicles (OTVs). The moons, Phobos and Deimos, may hold resources for refueling future space vehicles. In-situ resource utilization (ISRU) can be a powerful method of reducing Earth dependence on space vehicle propellants, liquid water, and breathing gases. Historical studies have identified the potential of water in carbonaceous chondrites on the moons. The moon-derived propellants OTVs that move payloads between the moons and to other important operational Mars orbits. Also, the propellants have been suggested to support reusable Mars landers. To extract the water, the mined mass, its volume and the mining time were estimated. The water mass fraction may be as low as 2x10−4. Very large masses were needed to be extracted for up to 100 MT of water.

So long as the oceans are the ligaments which bind together the great, broadcast British Empire, so long will there be a dash of romance in our minds. For the soul is swayed by the waters, as the waters are by the moon,...

As we saw it first it was the wildest and most desolate of scenes. We were in an enormous amphitheatre, a vast circular plain, the floor of the giant crater. Its cliff-like walls closed us in on every side. From the westward the light of the unseen sun fell upon them, reaching to the very foot of the cliff, and showed a disordered escarpment of drab and greyish rock, lined here and there with banks and crevices of snow. This was perhaps a dozen miles away, but at first no intervening atmosphere diminished in the slightest the minutely detailed brilliancy with which these things glared at us. They stood out clear and dazzling against a background of starry blackness that seemed to our earthly eyes rather a gloriously spangled velvet curtain than the spaciousness of the sky.

I remember how one day Cavor suddenly opened six of our shutters and blinded me so that i cried aloud at him. The whole area was moon, a stupendous scimitar of white dawn with its edge hacked out by notches of darkness, the crescent shore of an ebbing tide of darkness, out of which peaks and pinnacles came climbing into the blaze of the sun. I take it the reader has seen pictures or photographs of the moon,^* so that I need not describe the broader features of that landscape, those spacious ringlike ranges vaster than any terrestrial mountains, their summits shining in the day, their shadows harsh and deep, the grey disordered plains, the ridges, hills, and craterlets, all passing at last from a blazing illumination into a common mystery of black. Athwart this world we were flying scarcely a hundred miles above its crests and pinnacles. And now we could see, what no eye on earth will ever see, that under the blaze of the day the harsh outlines of the rocks and ravines of the plains and crater floor grew grey and indistinct under a thickening haze, that the white of their lit surfaces broke into lumps and patches, and broke again and shrank and vanished, and that here and there strange tints of brown and olive grew and spread.

“Pay attention to details, as Earth is an oblate spheroid” explains that, due to gravitational and rotational forces, all planets in the solar system could more accurately be described as oblate spheroids—squashed spheres—rather than spheres. For example, the difference between Earth’s polar and equatorial diameters is small—approximately 26 miles—but present. Saturn’s moons, which have been described as tiny ravioli, are also not spherical. Many cosmologists believe not in an infinite universe but a doughnut-shaped universe. The discussion is illustrated with numerous hand-drawn sketches. In this chapter, mathematics students and enthusiasts learn some of the “why” behind these facts, in addition to fostering an appreciation for paying attention to the smallest details in mathematics and life. At the chapter’s end, readers may check their understanding by working on a problem. A solution is provided.

Chapter 4 examines all of Parker’s complete 32-bar compositions that are in ABAC form. There are only four of these, and one of them (“Ornithology”) is generally credited as a co-composition to Parker and Benny Harris. It is based on the form and harmonies of “How High the Moon” (Hamilton-Lewis). Parker performed “Ornithology” consistently through his career, perhaps because the conjunction of “Bird” and “Ornithology” was too tempting to ignore. “Donna Lee,” while credited to Parker, is widely considered to have been written by Miles Davis. One of the most popular compositions associated with Parker, “Donna Lee” is based on “Back Home in Indiana” (MacDonald-Hanley). The final two works, “Quasimodo” and “Cardboard,” are less known, but are fine compositions.

For the majority of Australian gas pipelines it is not practical to remove them from service for extended periods of time. This rules out hydrostatic testing as a means of confirming the integrity of older pipelines including those that may contain Stress Corrosion Cracking (SCC). The Moomba to Sydney pipeline (MSP) at 864 mm (34 inch) nominal bore and 1299 km (807 miles) in length is the largest diameter onshore gas transmission pipeline in Australia. Commissioned in 1976, it has a history of susceptibility to SCC and, in 1982, six years after commissioning, suffered a SCC initiated rupture. Since this time the pipeline owners have operated and maintained the pipeline to ensure no further SCC initiated failures. Maintenance for SCC has included a targeted excavation program which, between 2000 and 2004, found significant SCC colonies. This created the need to develop a more comprehensive approach to locate and identify every significant SCC colony in the pipeline. Several options were considered but the one that was selected as best meeting the performance criteria was the use of an ultrasonic intelligent pig running in a liquid medium. This pigging operation had to be carried out while the pipeline continued in operation with minimal disruption to gas transmission operation. This had never been done before in Australia. The initial intelligent pigging program of the first 162 km (101 miles) of the pipeline was conducted in early 2005 with an additional 292 km (181 miles) pigged in early 2006. This paper provides information on the approach taken to overcome the many technical, operational and commercial challenges of this operation. Water was chosen as the liquid medium and a major issue was the introduction and removal of water from the pipeline while it remained in operation. This could not have been achieved without the co-operation of producers, shippers, network owners, network operators, technical regulators and contractors. The paper also looks at the how the results obtained from the pigging will be used to enable the SCC to be managed in a safe and efficient manner and confirming the safety and fitness for purpose of the MSP now and into the future.

This paper explores whether students are customers, students, or both students and customers. The following are discussed: How do administrative members (deans, assistant deans, chairs, assistant chairs), full-time faculty, and adjunct faculty members within an online post-secondary learning institution perceive their students’ status within the organization? Are the students purely students, or are the students also customers? What paradigm exists within the minds of the administrative members and faculty members? If the students are purely students, then is the online post-secondary learning institution purely a function of scholarly excellence? Conversely, if the students are customers, then is the online post-secondary learning institution predominantly a business that is selling a product and must go to great lengths to keep the e-customer happy? What are the perceptions of administration and faculty? Are the students purely students, or are the students also customers? Furthermore, if the online post-secondary learning institution recognizes that there are, indeed, customers, is it sure that the students are the customers? Perhaps some administrative members and faculty members consider the customers to be the final consumers of the product, so consideration of whether the students are purely students or whether the students are customers is moot.

A curing press is used in the final phase of tire manufacture. A tire semi product is placed into the curing press mold and a specific pressure and temperature gives it its final shape and final mechanical properties. There are many types of curing presses; this particular press is mechanical and the pressing force is exerted by an eccentric mechanism. The size of this press allows production of tires for trucks and medium-sized tractors. The basic demands placed on this type of press include tightness of the parts which are exposed to pressure from the heating medium. This paper mainly focuses on the tightness of the vulcanizing chamber and the tightness of the mold in which the semi product of the tire is inserted. Leakage of the vulcanizing chamber may cause leakage of the heating medium which could result in injury to the machine operator. Leakage of the mold causes an overflow of rubber into the parting plane, which may result in the production of rejects. To ensure the tightness of both these components, it is necessary to create sufficient pressure between the individual components. The value of the compressive force depends on the setting of the overlap of these parts, which depends on the stiffness of the individual parts and on the force exerted from the pressure of the heating medium that acts on these parts. Finite element method (FEM) analysis of this problem was performed using Abaqus software. A computational model of the curing press was created for this numerical analysis. The geometry of the press is symmetrical and the load is centric, therefore, only half of the press was modelled. The aim of this analysis was to find the most suitable settings for the overlap of the mold (independent variable) and the overlap of the chamber (dependent variable) which ensure the smallest possible leakage of the mold and an uninterrupted contact surface between the sealing and the upper part of the chamber. The sealing of the chamber is made from rubber which was modelled for the analysis as a five term generalized Mooney-Rivlin model, also known as the James-Green-Simpson model. This model assumes hyperelastic behavior with incompressibility. The insulating plates are made of a particulate composite which was considered to be linear with isotropic properties. For strength evaluation of the composite materials, all individual components of the stress tensor were investigated according to the maximum stress criterion. Hook’s law was considered to be valid for all the metallic materials. The Von Mises criterion was used to evaluate the strength of the metallic materials. The geometry of the press was discretized using 3D linear elements with 8 nodes and with reduced integration (C3D8R). The geometry of the rubber sealing was discretized using hybrid 3D linear elements with 8 nodes and with reduced integration (C3D8RH). The overall number of elements was approximately 97,000. Calculation model enabled to compute the best overlap setting of the chamber and the mold. This setting ensures their tightness. Effect of the setting to a stress in a press was also studied and the values of the stress were in a permitted range.

Modern automobiles collect around 25 gigabytes of data per hour and autonomous vehicles are expected to generate more than 100 times that number. In comparison, the Apollo Guidance Computer assisting in the moon launches had only a 32-kilobtye hard disk. Without question, the breadth of in-vehicle data has opened new possibilities and challenges. The potential for accessing this data has led many entrepreneurs to claim that data is more valuable than even the vehicle itself. These intrepid data-miners seek to explore business opportunities in predictive maintenance, pay-as-you-drive features, and infrastructure services. Yet, the use of data comes with inherent challenges: accessibility, ownership, security, and privacy. Unsettled Legal Issues Facing Data in Autonomous, Connected, Electric, and Shared Vehicles examines some of the pressing questions on the minds of both industry and consumers. Who owns the data and how can it be used? What are the regulatory regimes that impact vehicular data use? Is the US close to harmonizing with other nations in the automotive data privacy? And will the risks of hackers lead to the “zombie car apocalypse” or to another avenue for ransomware? This report explores a number of these legal challenges and the unsettled aspects that arise in the world of automotive data