Academic literature on the topic 'Monoamides'
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Journal articles on the topic "Monoamides"
McCann, Kevin, Sergey I. Sinkov, Gregg J. Lumetta, and Jenifer C. Shafer. "Inner versus outer sphere metal-monoamide complexation: ramifications for tetravalent & hexavalent actinide selectivity." New Journal of Chemistry 42, no. 7 (2018): 5415–24. http://dx.doi.org/10.1039/c7nj04851c.
Full textCanela-Xandri, Anna, Gemma Villorbina, Mercè Balcells, Xavier Fernández-Francos, Luisa F. Cabeza, and Ramon Canela-Garayoa. "Synthesis and Thermophysical Characterization of Fatty Amides for Thermal Energy Storage." Molecules 24, no. 20 (October 21, 2019): 3777. http://dx.doi.org/10.3390/molecules24203777.
Full textSieffert, Nicolas, and Georges Wipff. "Uranyl extraction by N,N-dialkylamide ligands studied using static and dynamic DFT simulations." Dalton Transactions 44, no. 6 (2015): 2623–38. http://dx.doi.org/10.1039/c4dt02443e.
Full textJones, R., A. G. M. Rattray, S. J. Rettig, J. R. Scheffer, and J. Trotter. "Structures and photochemistry of dibenzobarrelene monoamides." Acta Crystallographica Section B Structural Science 52, no. 6 (December 1, 1996): 1007–13. http://dx.doi.org/10.1107/s0108768196009056.
Full textPintus, Anna, M. Carla Aragoni, Gianfranco Carcangiu, Laura Giacopetti, Francesco Isaia, Vito Lippolis, Laura Maiore, Paola Meloni, and Massimiliano Arca. "Density functional theory modelling of protective agents for carbonate stones: a case study of oxalate and oxamate inorganic salts." New Journal of Chemistry 42, no. 14 (2018): 11593–600. http://dx.doi.org/10.1039/c8nj01714j.
Full textFischer, Róbert, and Mária Fišerová. "Direct synthesis of furan-2,5-dicarboxylic acid monoamides." Arkivoc 2015, no. 7 (September 16, 2015): 113–21. http://dx.doi.org/10.3998/ark.5550190.p009.239.
Full textValerio-Alfaro, Gerardo, Patricia Harumi Castillo-Carrasco, Olaya Pirene Castellanos Onorio, and Jorge Bautista Naranjos. "Highly Efficient Lipase Catalyzed Monoaminolysis Reaction of Diesters with Benzylamine." Natural Product Communications 14, no. 6 (June 2019): 1934578X1985998. http://dx.doi.org/10.1177/1934578x19859980.
Full textGiroux, Se´bastien, Patrice Rubini, Christine Ge´rardin, Claude Selve, and Bernard Henry. "Hydrophobic tartaric acid monoamides as complexing and tensioactive agents." New Journal of Chemistry 24, no. 3 (2000): 173–78. http://dx.doi.org/10.1039/a909430j.
Full textKlimenkovs, Igors, Eduards Bakis, and Anda Priksane. "Propanephosphonic Acid Anhydride–Mediated Cyclodehydration of Maleic Acid Monoamides." Synthetic Communications 43, no. 19 (June 26, 2013): 2634–40. http://dx.doi.org/10.1080/00397911.2012.727060.
Full textWauke, Hisashi, Kazumasa Matsuo, Kenji Matsumoto, and Mitsuru Shindo. "Synthesis of Dissymmetric Malonic Acid Monoamides from Symmetric Dithiomalonates." ChemistrySelect 1, no. 21 (December 16, 2016): 6830–33. http://dx.doi.org/10.1002/slct.201601694.
Full textDissertations / Theses on the topic "Monoamides"
Ferru, Geoffroy. "Spéciation moléculaire et supramoléculaire des systèmes extractants à base de monoamides." Paris 6, 2012. http://www.theses.fr/2012PA066612.
Full textThe DEHiBA was chosen as extractant for the selective recovery of uranium in the GANEX process first cycle, which aims to realise the grouped extraction of actinides in a second step. The object of this work is to improve the description of monoamide organic phases in alkanes after solutes extraction. A parametric study was undertaken to study singly water, nitric acid and uranyl nitrate extraction at the molecular and supramolecular scale. The study of the organization has allowed identifying three regimes: For extractant concentration less than 0. 5 mol/L, monomeric species are majority, whatever the solute. For extractant concentration between 0. 5 and 1 mol/L, small aggregates are formed: after water and nitric acid extraction, this is essentially dimers. Uranyl nitrate extraction generates bigger objects, containing 2 to 4 molecules of monoamide. For more concentrated phases (more than 1 mol/L), species containing 2 to 4 molecules of monoamides could be formed after water or nitric nitric extraction. Concerning uranyl nitrate extraction, an important and strong organization of the organic phase is observed, which no longer allowing considering the formation of spherical well defined aggregates. From the molecular view, complexes are not sensitive to the organization of the solution: same species are observed, whatever the concentration of uranyl and of extractant in organic phase
Amoudji, Amivi Eméfa Félicité. "Comportement électrochimique du cérium et du plutonium dans les milieux organiques extractants monoamides." Electronic Thesis or Diss., Montpellier, Ecole nationale supérieure de chimie, 2022. http://www.theses.fr/2022ENCM0009.
Full textMonoamides extractants are being studied in recent years as alternate extractants to TBP for irradiated nuclear fuels reprocessing. Their extracting strength and selectivity toward Pu(IV) can be tuned depending on the nature of their alkyl chain and the nitric acid concentration. Like TBP, monoamides can extract water and nitric acid while in contact. However, nitric acid is unstable in both aqueous and organic phases. Due to radiolysis, it can be disproportionate in nitrous acid (HNO2) which is known to possess redox properties. It could lead to the formation of the HNO3/HNO2 redox couple which may cause several parasitic redox reactions and affect the recycling process. Meaningful the redox speciation of actinides (An) in an organic phase is important for acute control of the recycling processes. The electrochemical behavior of the Ce(IV)/Ce(III) couple have been studied at 25 and 40°C by cyclic voltammetry at a vitreous carbon working electrode in three N,N-dialkylamides solvents (DEHBA (N,N-di-(2-ethylhexyl)-n-butanamide), DEHiBA (N,N-di-(2-ethylhexyl)-iso-butanamide) and DEHDMBA (N,N-di-(2-ethylhexyl-)3,3-dimethylbutanamide)) pre-equilibrated with aqueous nitric acid solutions (HNO3 5M). Results showed that the Ce(IV)/Ce(III) redox process exhibits a well-defined reversible couple with a diffusion-controlled electrochemical behavior. This initial study on the Ce(IV)/Ce(III) couple, a "non-radioactive model" of the Pu(IV)/Pu(III) couple has been an entry to the direct electrochemical characterization of plutonium in these extractants aiming to identify the nature of the electrochemical process of the Ce(IV)/Ce(III) couple and the difficulties associated with carrying out electrochemical measurements in these viscous and low conductive media. The Pu(IV)/Pu(III) couple has been studied at 40°C in DEHBA at a vitreous carbon working electrode at different concentrations of nitric acid (0,6 M < [HNO3]org < 3,7 M). The study of the speciation of plutonium (IV) in the organic DEHBA phase after extraction showed the presence of two types of plutonium(IV) complexes with variable predominance due to the nitric acid concentration. Cyclic voltammetry measurements showed an significant effect of the speciation of plutonium in the organic phase on the electroactivity of the Pu(IV)/Pu(III) couple. At low nitric acid concentrations, the Pu(IV)/Pu(III) redox process exhibits a well-defined reversible couple with a diffusion-controlled electrochemical behavior. At higher nitric acid concentrations, no electrochemical response of the Pu(IV)/Pu(III) couple is observed. This study enabled the determination of physic and chemical characteristics of the Ce(IV)/Ce(III) and Pu(IV)/Pu(III) couples in N,N-dialkylamides media as the redox potential and the diffusion coefficient that were not previously studied. This study validates the implementation of electrochemical method for the quantification of tetravalent metallic cation in organic phases
Berlemont, Romain. "Etude cinétique d'extraction de l'uranium(VI) et du plutonium(IV) par des extractants monoamides." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066320/document.
Full textThis thesis was conducted in the framework of the reprocessing of spent nuclear fuels. The kinetics extraction of uranium(VI) and plutonium(IV) by N,N-dialkylamides or monoamides in an aliphatic diluent were studied from an aqueous nitric solution using 3 different techniques: “single drop technique”, Nitsch cell and Rotating Membrane Cell (RMC). All these experiments were useful to attempt the identification of the transfer process between the phases which can be controlled by kinetic or diffusional regime. The kinetics of extraction of U(VI) by monoamides solvent seems to be similar to that of the Pu(IV). In general, molecular diffusion in organic phase slows down the extraction process and the limiting thickness of organic phase increases with solvent viscosity. The process in “single drop technique” seems to be controlled not only by diffusion but also by the chemical reaction. Then the extraction kinetics of U(VI) has been carried out by Nitsch cell and the RMC. Diffusionnal regime is the limiting step in Nitsch cell and the results confirm that molecular diffusion in organic phase should mainly control the kinetics transfer. Then experiments performed by the RMC indicate that the kinetics is in the same order as transfer coefficient obtained by “single drop” and the chemical reaction occurs at the interface. Finally, these results were compared with data obtained with a TBP solvent (tributyl phosphate) currently used in the PUREX process in order to estimate the interest of such a new solvent. The kinetics of extraction of U(VI) by this monoamide-based solvent is three times lower that of the TBP 30 % but remains fast and suitable for a future industrial process
Ribokaite, Kristina. "Etude théorique et expérimentale de complexes d’actinides avec des ligands monoamides et organophosphorés en solution." Paris 6, 2013. http://www.theses.fr/2013PA066458.
Full textMonoamides and organophosphate are of great interest for the nuclear fuel cycle. Such ligands can selectively extract actinides in liquid-liquid extraction processes. The structure of the extractant (its functional group and its alkyl substituents) has a predominant role in the selective separation of actinides. This thesis concerns the theoretical and experimental studies of model systems in the aim of better understanding of the effect on molecular structures of the complexes. Structures of actinides complexes formed with model ligands in simple media (water or methanol in the presence of nitrate ions) have been characterized. At first, the complexation of uranyl by monoamide and phosphine oxide was studied in water and methanol. Molecular Dynamics simulations and DFT calculations were used to quantify the stability of uranyl complexes with those ligands, and to determine their structural properties. The theoretical results were then compared with experimental results obtained by UV-visible, infrared, Raman and EXAFS on the same chemical systems. The results were used to highlight the greater stability of uranyl complexes with phosphine oxide and monoamides. Further spectroscopic measurements combined with molecular modeling were used to gain a better understanding of the coordination mode of nitrate ion around the uranyl in both water and methanol. Finally, DFT calculations were used to study the influence of the structure of the monoamide or organophosphorus ligand and their interaction with the actinides (IV, VI) including steric effects in the first coordination sphere
Lopes, Moreira Sandra. "Synthèse et évaluation de nouveaux monoamides pour l’extraction de l’uranium(VI) et du plutonium(IV)." Nantes, 2013. https://archive.bu.univ-nantes.fr/pollux/show/show?id=7b1d6f98-ec99-4912-92b1-57de201f818d.
Full textThis thesis, conducted in the framework of the reprocessing of spent nuclear fuels, concerns the design and evaluation of new monoamides to study the influence of the branched alkyl groups grafted on the amide function on uranium (VI) and plutonium (IV) extraction. Forty two new monoamides, with modifications on carbonyl side or on the nitrogen atom side, were synthesized. These monoamides were designed in order to establish a relationship between the monoamide structure and its affinity and selectivity relatively towards U(VI) and Pu(IV). Liquid-liquid extraction tests were systematically performed with these ligands at 4M and 0,5M HN03 in order to measure the distribution ratios and the U(VI)/Pu(IV) selectivity. The results confirmed the strong influence of the steric hindrance due to branched alkyl groups on the carbonyl side on the U(VI)/Pu(IV) selectivity but have also shown the importance of the steric hindrance on the nitrogen side. The single behaviour of the unsymmetrical monoamides observed for Pu(IV) extraction allowed the design a new molecule with higher performances than the reference monoamide. Finally, extractions isotherms on two relevant ligands were performed in order to determine the stoichiometry of the actinide-ligands complexes formed in organic phase and to assess the performances of this new ligand in process conditions
Moeyaert, Pauline. "Etude expérimentale et modélisation des mécanismes d’extraction des produits de fission et des actinides mineurs par des extractants de la classe des monoamides." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT199.
Full textThe PUREX process is a solvent extraction method dedicated to the reprocessing of irradiated nuclear fuel in order to selectively extract uranium(VI) and plutonium(IV) from fission products and minor actinides. The tri-n-butylphosphate (TBP) is used as the extractant in the organic phase. Within the frame of the development of Generation IV reactors, new liquid-liquid extraction processes are under development for the reprocessing of spent nuclear fuels. The N,N-dialkylamides (monoamides) already showed their potentiality as promising alternative extractant to TBP for nuclear fuel reprocessing: they are able to extract U(VI) and Pu(IV) selectively by adjusting the nitric acid concentration without using Pu(IV) reducing agents. This study aims at understanding and modeling the extraction of some fission products and minor actinides: cesium, europium, americium, ruthenium and technetium, which may occur as impurities in the organic phase. In the present study, the extraction properties of N,N-di (ethyl-2 hexyl) butanamide (DEHBA), N,N-di (ethyl-2 hexyl) isobutanamide (DEHiBA), as well as a mixture of these two monoamides, N-methyl-N-octyl-(2-ethyl)hexanamide (MOEHA) and TBP, the extractant currently used in the PUREX process at the La Hague plant, diluted in TPH, were studied. For that purpose, a multi-scale approach has been used to describe the extraction mechanisms combining two different descriptions. Distribution and thermodynamic data were first determined from batch experiments. Based on these data, thermodynamic models were developed and are able to predict the behaviour of the different elements in current or future processes. Dedicated methods were also performed to obtain information about the stoichiometry of the extracted species and about the mechanisms involved during the extraction step.The main conclusions that can be deduced from this study are:- even if the extraction of cesium, europium and americium nitrates with monoamides is very low, models have been developed and fit the experimental data with good agreement,- the same mechanism may be involved in the extraction of technetium with TBP or monoamides: technetium is preferentially co-extracted in organic phase as mixed uranium-technetium species. Indeed, one TcO4- anion replaces one NO3- ion in a monodentate coordination mode in the uranium-monoamide complex. The developed thermodynamic models, that have been improved by taking into account a new variation of the pertechnetic acid activity coefficient in binary solution, fit very well the experimental data,- with monoamides as with TBP, ruthenium is poorly extracted but remains troublesome in the spent fuel reprocessing industry because of its retention in the irradiated solvent. Distribution data have first been determined from batch experiments thanks to the development of a new methodology for simulated ruthenium spent fuel dissolution solutions preparation. The developed thermodynamic models fit very well the batch experimental data. Thus, they was then used to simulate ruthenium behaviour in counter-current hot tests performed in mixer-settlers- a new approach for the activity coefficient calculation in organic phase has been developed. The MSA theory (Mean Spherical Approximation) was chosen for this purpose to explicitly describe both association and repulsive forces.Finally, this work that includes a macroscopic study (distribution and thermodynamic data acquisition and modeling) and molecular investigations (ESI-MS, FT-IR and X-ray absorption analysis supported by theoretical calculations) provides a new insight in the description of solvent extraction mechanism
Rabbe, Catherine. "Apport de la modélisation moléculaire et des relations structure-activité à l'extraction liquide-liquide. Application au cas de l'extraction d'U(VI) par les monoamides." Rouen, 1996. http://www.theses.fr/1996ROUES028.
Full textRabbe, Catherine. "Apport de la modélisation moléculaire et des relations structure-activité à l'extraction liquide-liquide : application au cas de l'extraction d'U(VI) par les monoamides /." Gif-sur-Yvette : Direction de l'information scientifique et technique, CEA Saclay, 1996. http://catalogue.bnf.fr/ark:/12148/cb369615416.
Full textCitÃ, Maria do Carmo de Oliveira. "AlteraÃÃes comportamentais e neuroquÃmicas provocadas por diferentes perÃodos de retirada apÃs tratamento subcrÃnico com cocaÃna em ratos: envolvimento dos sistemas dopaminÃrgico, serotonÃrgico e noradrenÃrgico." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=3986.
Full textA cocaÃna à uma droga consumida mundialmente e considerada hoje como um problema de saÃde pÃblica. Uma das principais dificuldades enfrentadas no combate ao vÃcio da cocaÃna, na maioria dos casos, està relacionada aos sintomas de abstinÃncia da droga, como ansiedade, depressÃo, irritabilidade, fadiga e insÃnia, fazendo com que o indivÃduo volte a procurÃ-la. Para avaliar as alteraÃÃes comportamentais (ansiedade e depressÃo) e neuroquÃmicas, os ratos foram submetidos Ãs retiradas de 24 h, 7 d e 21 d apÃs o tratamento subcrÃnico por 7 dias com cocaÃna (20mg/kg), sendo realizados os modelos experimentais de Labirinto de Cruz Elevado (LCE), Campo Aberto (CA) e Nado ForÃado (NF). AlÃm disso, na abstinÃncia de 24h foram testados o propranolol (10mg/kg, i.p.), o ondansetrom (4mg/kg, i.p) e a buspirona (5 mg/kg, i.p.), no LCE e CA, bem como na abstinÃncia de 21 d foram testados a bupropiona (30mg/kg, i.p.) e paroxetina (10 mg/kg, i.p.) no NF, com o intuito de reverter tais alteraÃÃes comportamentais provocadas pela retirada forÃada do tratamento subcrÃnico com cocaÃna. Para o estudo neuroquÃmico (neuroadaptaÃÃo) foi utlizado o corpo estriado (CE) de ratos, avaliando-se os seguintes parÃmetros: nÃveis de monoaminas (NA, DA, 5-HT) e seus metabÃlitos (DOPAC, HVA e 5-HIAA) atravÃs do HPLC com detecÃÃo eletroquÃmica e a atividade da enzima catalase. Na avaliaÃÃo da ansiedade, os resultados mostraram que no LCE houve uma reduÃÃo do NEBA, PEBA, TPBA e PTBA na abstinÃncia de 24h e 7 d, apÃs 21d nÃo houve alteraÃÃo. No CA, as retiradas de 24h e 7 d promoveram um aumento da atividade locomotora do animal, no entanto na retirada de 21 d ocorreu uma diminuiÃÃo da atividade locomotora. Na abstinÃncia de 24h foram administrados propranolol, ondansetrom e buspirona. No LCE, o propranolol aumentou o NEBA e reduziu o PTBA, enquanto que o ondansetrom aumentou o NEBA, PEBA, TPBA e o PTBA em relaÃÃo ao grupo da cocaÃna. Jà a buspirona em relaÃÃo à cocaÃna aumentou o PTBA, TPBA e o PEBA, porÃm o NEBA foi reduzido. Enquanto que no CA, o propranolol, o ondansetrom e a buspirona reduziram a atividade locomotora em relaÃÃo ao grupo da cocaÃna. Para avaliar a atividade antidepressiva foi realizado o teste do nado forÃado, no qual as retiradas de 24h e 7 d reduziram o tempo de imobilidade, contudo na abstinÃncia de 21 d houve um aumento do parÃmetro avaliado. Na abstinÃncia de 21 d foram administrados paroxetina e bupropiona, verificando uma reduÃÃo do tempo de imobilidade em relaÃÃo ao grupo da cocaÃna. Para a realizaÃÃo dos estudos neuroquÃmicos, os animais foram dissecados para retirada do CE. No corpo estriado observou-se um aumento de dopamina (DA) e uma reduÃÃo de seus metabÃlitos (DOPAC e HVA) nas trÃs retiradas. A concentraÃÃo de serotonina aumentou nas trÃs retiradas, entretanto o seu metabÃlito (5HIAA) aumentou somente nas retiradas de 24h e 7d. Jà a noradrenalina reduziu apÃs as trÃs retiradas. Em relaÃÃo aos receptores, no corpo estriado D2 encontrava-se elevado em 24h e 7d, jà 5HT2 apÃs 7d e D1 nÃo foi alterado. Foi tambÃm avaliado no CE a atividade da catalase, enzima antioxidante, que mostrou uma reduÃÃo de sua atividade nas trÃs retiradas. Os resultados sugerem que diferentes perÃodos de retirada apÃs tratamento subcrÃnico com cocaÃna causam efeitos ansiogÃnicos e depressores sobre o SNC e tais efeitos foram revertidos por propranolol, ondansetrom, buspirona, bupropiona e paroxetina. O estudo neuroquÃmico mostrou que a abstinÃncia de cocaÃna sÃo eventos multimediados e que CE tem uma importante participaÃÃo, estando tambÃm a atividade da catalase envolvida neste processo. Estes achados sÃo importantes para a investigaÃÃo de novos tratamentos para a sÃndrome de abstinÃncia de cocaÃna.
Cocaine is world used and considered as a public health problem, being the relapse one of the hardly difficulties faced by cocaine users, that in the most cases, is related to abstinence symptoms, like anxiety, depression, irritability, fatigue and sleeplessness. To evaluate the behavioral alterations (anxiety and depression) and neurochemistry, rats were submitted to 24h, 7 d and 21 d withdrawal, after the subcronic treatment, for 7 days with cocaine (20mg/kg), being realized the experimental models of Elevated Plus Maze (EPM), Open Field (OF) and Forced Swimming (FS). Moreover, in the 24h abstinence, propranolol (10mg/kg, i.p.), ondansetrom (4mg/kg, i.p) and buspirone (5 mg/kg, i.p.) had been tested, in the EPM and OF, as wel as in the 21 d of abstinence bupropione (30mg/kg, i.p.) and paroxetine (10 mg/kg, i.p.) had been tested in the FS, aiming to revert the alterations caused by the abstinence of cocaine subcronic administration. For the neurochemistry study (neuroadaptation) was used striatum (ST) of rats, evaluating the following parameters: level of monoamines (NE, DA and 5HT) and its metabolites (DOPAC, HVA and 5HIAA), using the electrochemistry detection HPLC and the activity of the catalase enzyme. In the anxiety evaluation, results showed that in the EPM there was a reduction on NEOA, PEOA, TPOA and PTOA in the abstinence of 24h, 7 d and 21 d. In the OF, the withdrawal of 24 and 7 d promoted an increasing in the locomotor activity of animals, while the withdrawal of 21 d a decreasing in the locomotor activity was observed. In the 24h abstinence were administered propranolol, ondansetrom and buspirone. In the EPM, propranolol increased NEOA and reduced PTOA, while ondansetrom increased NEOA, PEOA, TPOA and PTOA, as compared to cocaine group. In addition buspirone as compared to cocaine group increased PTOA, TPOA, and PEOA, however NEOA was reduced. While in the OF, propranolol, ondansetron and buspirone reduced the locomotor activity as related to cocaine group. To evaluate the antidepressive effect the FS was performed, where the withdrawal of 24h and 7 d reduced the immobility time, although in the 21 d abstinence an increase of this parameter was observed. In the 21 d abstinence had been administered paroxetine and buproprione, verifying a reduction of the immobility time as related to cocaine group. To the performance of neurochemistry studies, animals were dissected to take off the ST. In the ST was observed an increasing of dopamine (DA) and a reduction of its metabolites (DOPAC and HVA) in the three withdrawals. The serotonine levels increased the three withdrawals, however its metabolite (5HIAA) increased only in the 24h and 7 d withdrawals. In addition norepinephrine reduced after the 24h, 7 d and 21 d withdrawal. In relation to the receptors, in the ST D2 24h and 7d met high in, already 5HT2 after 7d and D1 was not alteration. Were evaluated too in the ST the activity of catalase, antioxidant enzyme, that showed a reduction of your activity in the three withdrawal. Results suggests that different times of withdrawal after subcronic treatment with cocaine cause anxyogenic and depressive effects on the CNS and this effects were reverted by the administration of drugs (propranolol, ondansetrom, buspirone, bupropione and paroxetine). The neurochemistry study showed that the abstinence of cocaine were events multimediated and the brain area study ST has an important role, being the catalase activity involved in this process. These findings are important to the investigation of new treatments to the cocaine abstinence syndrome.
Aguiar, Lissiana Magna Vasconcelos. "Efeitos comportamentais e neuroquÃmicos da melatonina em ratos submetidos à lesÃo estriatal com 6-ohda." Universidade Federal do CearÃ, 2002. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=19.
Full textOs efeitos da melatonina (Mel) in vivo foram estudados no sistema dopaminÃrgico nigroestriatal de ratos, utilizando um modelo experimental da doenÃa de Parkinson que consiste na injeÃÃo intraestriatal da neurotoxina 6-hidroxidopamina (6-OHDA). Ratos Wistar, machos (200-250g) foram submetidos a lesÃo unilateral com 6-OHDA, tratados com melatonina nas doses de 2, 5, 10 e 25 mg/kg, i.p. 1 hora apÃs a lesÃo e depois, diariamente durante 7 dias, quatro semanas apÃs a lesÃo, foi realizado o teste rotacional e 24 horas depois os animais foram sacrificados, os seus cÃrebros dissecados e os estriados direito (ipsilateral â lado lesionado) e esquerdo (contralateral â lado nÃo lesionado) utilizados para dosagens de monoaminas em HPLC e ensaios de binding dopaminÃrgico. Para as dosagens de malonildialdeÃdo (MDA), os animais foram sacrificados no oitavo dia apÃs a lesÃo. Os resultados demonstraram que a injeÃÃo intraestriatal de 6-OHDA diminuiu cerca de 77 à 85% os conteÃdos das monoaminas e dos seus metabÃlitos no lado ipsilateral quando comparado com o lado contralateral nos controles. O tratamento com melatonina, nas doses estudadas, reverteu parcialmente as diminuiÃÃes causadas pela lesÃo com 6-OHDA nos nÃveis destes neurotransmissores, e os conteÃdos se aproximaram de 50% daqueles observados nos lados contralaterais dos controles ou dos grupos tratados com melatonina. A Mel foi mais eficiente na dose de 5 mg/kg, i.p., e os efeitos foram similares entre as doses mais baixas e as mais altas, caracterÃstica de um tipo de resposta com a curva em forma de sino. O prÃ-tratamento e o tratamento crÃnico com melatonina na dose que obteve o melhor efeito tambÃm foram estudados, o tratamento crÃnico promoveu uma melhor recuperaÃÃo dos nÃveis de monoaminas enquanto os efeitos do prÃ-tratamento foram similares aos do grupo Mel 5 mg/kg, durante 7dias. O comportamento rotacional induzido pela apomorfina (3 mg/kg) foi bloqueado em cerca de 60, 89, 78 e 47% nos grupos tratados com melatonina nas doses de 2, 5, 10 e 25 mg/kg, i.p., respectivamente. O tratamento crÃnico bloqueou o comportamento rotacional em cerca de 96% e o prÃ-tratamento 86%. A melatonina (5 mg/kg) produziu uma upregulation dos receptores D1 (Bmax: 277,8+/-25,8) associada com uma diminuiÃÃo nos valores do Kd (1,5+/-0,1) quando comparado ao controle (Bmax:194,8+/-19,0; Kd:2,9+/-0,38). Um efeito similar foi observado com o tratamento com NAS (Bmax: 245,3+/-27,6; Kd: 1,1+/-0,28), precursor da melatonina. Foi verificado um aumento nos nÃveis de MDA, nos controles (127%), quando comparado com o grupo falso operado (104%), o tratamento com melatonina (106%) recuperou esses nÃveis à valores prÃximos do normal, sugerindo uma aÃÃo antioxidante da melatonina in vivo. Os resultados apresentados podem indicar uma aÃÃo neuroprotetora da melatonina e sugerem um possÃvel papel no tratamento de doenÃas neurodegenerativas causadas pelo estresse oxidativo, como a doenÃa de Parkinson.
The present work studied the neuroprotective effects of melatonin In vivo on the nigrostriatal dopaminergic system in rats after a unilateral 6-hydroxydopamine (6-OHDA) lesions in rat striatum. Results showed that the intrastriatal injection of 6-OHDA significantly decreases DA, DOPAC and HVA levels. Although there is also a decrease in 5-HT levels no changes were observed in 5-HIAA levels as compared to controls. On the other hand, melatonin (2, 5, 10 and 25 mg/kg, i.p., daily for 7 days) treatment starting 1 h after 6-OHDA lesions, partially reverses the decreases caused by 6-OHDA lesions on these neurotransmitter levels, and contents were brought to approximately 50% of that observed in the contralateral sides of controls or the melatonin treated group. Melatonin was more efficient at the doses of 5 and 10 mg/kg, i.p., and effects were similar between the lowest and highest doses characteristic of a bell-shaped type of response. Pretreatment and cronic treatment with melatonin at the 5mg/kg dose were also tested, cronic treatment promoted a recovey of monoamines levels more efficiently while the pretreatment effects were similar to the melatonin treatment at the dose of the 5mg/kg for 7 days. The apomorphine-induced rotational behavior (3 mg/kg, i.p.) was blocked by 60, 89, 78 and 47% after the doses of 2, 5, 10 and 25 mg/kg, i.p., respectively. Similarly, in this case the doses of 5 and 10 mg/kg were also more efficient. The cronic treatment blocked the rotational behavior by 86%. Melatonin (5mg/kg) produced an upregulation of D1 receptors associated with a decrease in Kd value. While no change was observed in maximum density of D2 receptors, the Kd value was also decreased, a similar effect was observed with its precursor N-acetylserotonin. Compared with sham-operated and expressed as a ratio relative to the contralateral side, there was an increase in the lipid peroxidation product malondialdehyde (MDA, 127%) on controls which was restored to normal levels on the melatonin treated group, suggesting the in vivo action of melatonin as an antioxidant. The present results may indicate a neuroprotective action of melatonin and suggest a possible role in the treatment of oxidative stress-induced neurodegenerative disease such as Parkinsonâs disease.
Books on the topic "Monoamides"
Binda, Claudia, ed. Monoamine Oxidase. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2643-6.
Full textOreland, Lars, and Brian A. Callingham, eds. Monoamine Oxidase Enzymes. Vienna: Springer Vienna, 1987. http://dx.doi.org/10.1007/978-3-7091-8901-6.
Full textNational Institutes of Health (U.S.), ed. Low monoamine (LMA) diet. [Bethesda, Md.?: U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 1989.
Find full textSzelenyi, I., ed. Inhibitors of Monoamine Oxidase B. Basel: Birkhäuser Basel, 1993. http://dx.doi.org/10.1007/978-3-0348-6348-3.
Full textRoberts, M. H. T. The central and antinociceptive actions of the monoamines. Birmingham: University of Birmingham, 1986.
Find full textH, Yasuhara, ed. Monoamine oxidase: Basic and clinical aspects. Utrecht, Netherlands: VSP, 1993.
Find full textVan Bockstaele, Elisabeth J., ed. Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7940-6.
Full textH, Kennedy Sidney, ed. Clinical advances in monoamine oxidase inhibitor therapies. Washington, DC: American Psychiatric Press, 1994.
Find full textEbrahimi, Soltan Ahmed. Characterisation of guinea pig liver monoamine oxidase. Portsmouth: University of Portsmouth, School of Pharmacy and Biomedical Science, 1995.
Find full textG, Priest R., ed. Depression and reversible monoamine oxidase inhibitors: New perspectives. London: Royal College of Psychiatrists, 1989.
Find full textBook chapters on the topic "Monoamides"
Morgan, Michael M., MacDonald J. Christie, Thomas Steckler, Ben J. Harrison, Christos Pantelis, Christof Baltes, Thomas Mueggler, et al. "Monoamines." In Encyclopedia of Psychopharmacology, 795. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_464.
Full textMorgan, Michael M., MacDonald J. Christie, Thomas Steckler, Ben J. Harrison, Christos Pantelis, Christof Baltes, Thomas Mueggler, et al. "Monoamine Depletion." In Encyclopedia of Psychopharmacology, 791. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_3405.
Full textMorgan, Michael M., MacDonald J. Christie, Thomas Steckler, Ben J. Harrison, Christos Pantelis, Christof Baltes, Thomas Mueggler, et al. "Monoamine Hypotheses." In Encyclopedia of Psychopharmacology, 791. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_3406.
Full textRey, Jose A. "Monoamine Oxidase." In Encyclopedia of Clinical Neuropsychology, 1654–55. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-79948-3_1742.
Full textRey, Jose A. "Monoamine Oxidase." In Encyclopedia of Clinical Neuropsychology, 1. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56782-2_1742-2.
Full textEdmondson, Dale E., and Claudia Binda. "Monoamine Oxidases." In Subcellular Biochemistry, 117–39. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-7757-9_5.
Full textRey, Jose A. "Monoamine Oxidase." In Encyclopedia of Clinical Neuropsychology, 2264. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_1742.
Full textHillard, Cecilia J. "Endocannabinoids, Monoamines and Stress." In Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders, 173–212. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7940-6_9.
Full textSinger, T. P. "Perspectives in MAO: past, present, and future." In Monoamine Oxidase Enzymes, 1–23. Vienna: Springer Vienna, 1987. http://dx.doi.org/10.1007/978-3-7091-8901-6_1.
Full textTipton, K. F., Anne-Marie O’Carroll, and J. M. McCrodden. "The catalytic behaviour of monoamine oxidase." In Monoamine Oxidase Enzymes, 25–35. Vienna: Springer Vienna, 1987. http://dx.doi.org/10.1007/978-3-7091-8901-6_2.
Full textConference papers on the topic "Monoamides"
Verlinden, Heleen. "Monoamine receptors and swarming behaviour in locusts." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.95192.
Full textSerra, Silvia, Eugenio Uriarte, Lourdes Santana, Giovanna Delogu, and Maria Matos. "Synthesis of New Possible Monoamine Oxidase Inhibitors." In The 14th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00378.
Full textSerra, Silvia, Eugenio Uriarte, Lourdes Santana, Giovanna Delogu, and Maria Matos. "Synthesis of new possible monoamine oxidase inhibitors." In The 14th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00474.
Full textBarmatov, Evgeny, and Dimitri Khramov. "Research on the Chemistry of Emulsifiers for Nonaqueous Drilling Fluids." In SPE International Conference on Oilfield Chemistry. SPE, 2023. http://dx.doi.org/10.2118/213873-ms.
Full textMa, Peixiang, Shanshan Wang, Feng Qu, and Yulin Deng. "Determination of Monoamine Oxidase Activity by Capillary Electrophoresis Method." In 2007 IEEE/ICME International Conference on Complex Medical Engineering. IEEE, 2007. http://dx.doi.org/10.1109/iccme.2007.4382056.
Full textBayer, A., E. Zrenner, H. J. Thiel, S. Ried, and D. Schmidt. "Early detection of anticonvulsant drug toxicity by colour vision tests." In Noninvasive Assessment of the Visual System. Washington, D.C.: Optica Publishing Group, 1991. http://dx.doi.org/10.1364/navs.1991.md10.
Full text"Monoamine signaling gene networks unraveled in mouse social stress model." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-172.
Full textYurttas, Leyla, Asaf Evren, Demokrat Nuha, Sam Dawbaa, and Begüm Sağlık. "New thiazolylhydrazone derivatives as potent monoamine oxidase and aromatase inhibitors." In 7th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11582.
Full textYan, Shaomin, and Guang Wu. "Distributions of amino acids in the primary structure of monoamine oxidase family." In International Conference on Biomedical and Intelligent Systems (IC-BIS 2022), edited by Ahmed El-Hashash. SPIE, 2022. http://dx.doi.org/10.1117/12.2660263.
Full textKamruzzaman, A. S. M. "Integration of midgut-fat body-gonadal axis inPeriplaneta americana: Monoamine and peptide regulation." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.94434.
Full textReports on the topic "Monoamides"
Mincher, Bruce Jay. Radiation chemistry of the branched-chain monoamide di-ethylhexyl-isobutyramide. Office of Scientific and Technical Information (OSTI), September 2016. http://dx.doi.org/10.2172/1406976.
Full textJacobs, Barry L. Central Postsynaptic Actions of Monoamine Neurotransmitters in Behaving Animals. Fort Belvoir, VA: Defense Technical Information Center, March 1997. http://dx.doi.org/10.21236/ada325701.
Full textGluck, Martin R. Parkinson's Disease: The Link Between Monoamine Oxidase and Mitochondrial Respiration. Fort Belvoir, VA: Defense Technical Information Center, April 2004. http://dx.doi.org/10.21236/ada612171.
Full textShih, Jean C., and Bogdan Z. Olenyuk. Monoamine Oxidase A: A Novel Target for Progression and Metastasis of Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada612725.
Full textShih, Jean C., and Bogdan Z. Olenyuk. Monoamine Oxidase A: A Novel Target for Progression and Metastasis of Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2013. http://dx.doi.org/10.21236/ada593309.
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