Academic literature on the topic 'Monkey; Brain; Neurology'

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Journal articles on the topic "Monkey; Brain; Neurology"

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Nakai, Mitsukazu, Toru Itakura, Ichiro Kamei, Kunio Nakai, Yutaka Naka, Harumichi Imai, and Norihiko Komai. "Autologous transplantation of the superior cervical ganglion into the brain of parkinsonian monkeys." Journal of Neurosurgery 72, no. 1 (January 1990): 91–95. http://dx.doi.org/10.3171/jns.1990.72.1.0091.

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✓ The effect of autologous transplantation of the superior cervical ganglion (SCG) into the brain of parkinsonian monkeys was studied through quantitative measurement of animal behavior. The motor activity of the monkey was measured with a telemetry system during the experiment. After experimental parkinsonism was induced by repeated intravenous injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), three monkeys were treated with autologous transplantation of the SCG into both caudate nuclei. One monkey served as a control without SCG transplantation after MPTP treatment. Three SCG-transplanted monkeys showed biphasic (acute and chronic) behavioral amelioration of parkinsonism after transplantation. In the acute stage, the animals showed transient hyperkinesia with aggressive behavior and loss of circadian rhythm. In the chronic stage following acute hyperkinesia, the animals regained normal behavior and circadian rhythm without aggressiveness. In contrast with the transplanted monkeys, the control monkey failed to show recovery of the bradykinesia and muscle rigidity.
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Fleischer, Jerry E., William L. Lanier, James H. Milde, and John D. Michenfelder. "Lidoflazine Does Not Improve Neurologic Outcome When Administered after Complete Cerebral Ischemia in Primates." Journal of Cerebral Blood Flow & Metabolism 7, no. 3 (June 1987): 366–71. http://dx.doi.org/10.1038/jcbfm.1987.74.

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In order to investigate the effects of the calcium entry blocker lidoflazine on neurologic outcome in primates following an episode of global brain ischemia. 12 pigtail monkeys ( Macaca nemestrina) were subjected to 17 min of complete cerebral ischemia, followed by 48 h of intensive care treatment and daily neurologic evaluations for 96 h. The monkeys were randomly assigned to receive, in a blind fashion, either lidoflazine 1.0 mg/kg (n = 6) or inactive lidoflazine solvent (n = 6) at 5 min, 8 h, and 16 h postischemia. One monkey in the lidoflazine group did not meet preestablished protocol criteria and was excluded from data analysis. The remaining monkeys were well matched for age, sex, and other physiologic variables. Neurologic outcome was not significantly different between the lidoflazine- and placebo-treated groups (p > 0.5). No monkey in either group achieved a normal neurologic exam by 96 h postischemia. Three lidoflazine-treated monkeys and two placebo-treated monkeys died prior to the 96-h neurologic evaluation. These deaths were judged to be neurologic in origin. The authors conclude that lidoflazine does not improve neurologic outcome in primates when administered after 17 min of complete cerebral ischemia.
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Tabuchi, Kazuo, Akira Nishimoto, Kengo Matsumoto, Toru Satoh, Susumu Nakasone, Takashi Fujiwara, and Hajime Ogura. "Establishment of a brain-tumor model in adult monkeys." Journal of Neurosurgery 63, no. 6 (December 1985): 912–16. http://dx.doi.org/10.3171/jns.1985.63.6.0912.

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✓ A brain-tumor model in adult monkeys may be significant because of the biological similarity to humans as well as the feasibility for surgical manipulation and for sequential computerized tomography (CT) scanning. In the present study, brain tumors were successfully produced in Japanese monkeys (Macaca fuscata), each weighing 2 to 10.8 kg, with an average age of 5.1 years old. Tumor cells were implanted by intracerebral inoculation of 4 × 107 chick embryo fibroblasts infected with the Schmidt-Ruppin strain of Rous sarcoma virus (RSV). With a 15- to 67-day latency, brain tumors were induced in 11 (73.3%) of 15 RSV-inoculated monkeys. Contrast-enhanced CT scans delineated all solitary intracerebral tumors greater than 4 to 6 mm in diameter. The CT images were proved at autopsy to be accurate within 2 mm in determining the size of tumor. Five of the 11 monkeys with intracerebral tumors died, with an average survival time of 26.6 days after RSV inoculation. The induced tumors were classified as either glioma or sarcoma by the presence or absence of glial fibrillary acidic protein (GFAP) and S-100 protein. A chromosome analysis of cultured tumor cells showed a diploid number of 42, indicating monkey origin. It is concluded that the reproducible brain tumor in the adult Japanese monkey inoculated with RSV can serve as a good experimental brain-tumor model for the further study of human malignant brain tumors.
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Obayashi, Shigeru, Tetsuya Suhara, Koichi Kawabe, Takashi Okauchi, Jun Maeda, Yoshihide Akine, Hirotaka Onoe, and Atsushi Iriki. "Functional Brain Mapping of Monkey Tool Use." NeuroImage 14, no. 4 (October 2001): 853–61. http://dx.doi.org/10.1006/nimg.2001.0878.

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Hossmann, K. A., and B. Grosse Ophoff. "Recovery of Monkey Brain after Prolonged Ischemia. I. Electrophysiology and Brain Electrolytes." Journal of Cerebral Blood Flow & Metabolism 6, no. 1 (February 1986): 15–21. http://dx.doi.org/10.1038/jcbfm.1986.3.

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Adult normothermic monkeys were submitted to 1 h of total cerebral ischemia, followed by blood recirculation for 1.5–24 h. During ischemia EEG and evoked potentials were suppressed within 12 s and 3 min, respectively. Upon recirculation, high-voltage EEG bursts began to reappear after 82–125 min, followed by gradual return of continuous background activity and near normalization of EEG frequency pattern within 24 h. Somatically evoked potentials, in contrast, exhibited only partial recovery, and consciousness did not return during the observation period. At the end of the experiments, tissue contents of sodium, potassium, calcium, and magnesium were measured in the gray and white matter of parietal lobe by atomic absorption spectros-copy. Gray matter sodium content gradually increased by ∼50% from 41.0 to 59.8 μmol/g wet wt during 24 h of recirculation. The other electrolytes including calcium did not change during the observation period. Postisch-emic recovery reported in this and the accompanying article is attributed to careful control of postischemic general physiological state and prevention or treatment of postischemic complicating side effects such as postischemic brain edema, hypotension, acidosis, pulmonary distress, and anuria. No specific drug treatment such as application of calcium antagonists or metabolic inhibitors was necessary to achieve this effect.
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MATSUMI, Nobuhiko, Kengo MATSUMOTO, Nobuya MISHIMA, Eiji MORIYAMA, Tomohisa FURUTA, Akira NISHIMOTO, and Kohji TAGUCHI. "Thermal Damage Threshold of Brain Tissue —Histological Study of Heated Normal Monkey Brains—." Neurologia medico-chirurgica 34, no. 4 (1994): 209–15. http://dx.doi.org/10.2176/nmc.34.209.

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NAKAGAWA, Minoru, Kengo MATSUMOTO, Hisato HIGASHI, Tomohisa FURUTA, and Takashi OHMOTO. "Acute Effects of Interstitial Hyperthermia on Normal Monkey Brain." Neurologia medico-chirurgica 34, no. 10 (1994): 668–75. http://dx.doi.org/10.2176/nmc.34.668.

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Wagner, Kenneth R., and Ronald E. Myers. "Topography of brain metabolites: Rhesus monkey, goat, and cat." Experimental Neurology 89, no. 1 (July 1985): 146–58. http://dx.doi.org/10.1016/0014-4886(85)90272-9.

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GHILARDI, M. FELICE, IVAN BODIS-WOLLNER, MARCO C. ONOFRJ, MARCIA S. MARX, and ANDREW A. GLOVER. "SPATIAL FREQUENCY-DEPENDENT ABNORMALITIES OF THE PATTERN ELECTRORETINOGRAM AND VISUAL EVOKED POTENTIALS IN A PARKINSONIAN MONKEY MODEL." Brain 111, no. 1 (1988): 131–49. http://dx.doi.org/10.1093/brain/111.1.131.

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KANAZAWA, ICHIRO, MINORU KIMURA, MIHO MURATA, YOSHIHARU TANAKA, and FUMIAKI CHO. "CHOREIC MOVEMENTS IN THE MACAQUE MONKEY INDUCED BY KAINIC ACID LESIONS OF THE STRIATUM COMBINED WITH L-DOPA." Brain 113, no. 2 (1990): 509–35. http://dx.doi.org/10.1093/brain/113.2.509.

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Dissertations / Theses on the topic "Monkey; Brain; Neurology"

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Easton, Alexander. "Interaction of the primate basal forebrain with cortex in learning." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312303.

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Book chapters on the topic "Monkey; Brain; Neurology"

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Kito, S., R. Miyoshi, K. Mizuno, K. Nitta, H. Matsubayashi, and Y. Yamamura. "Autoradiographic Distributions of Neurotransmitter Receptors in the Brain of Patients with Parkinson’s Disease and MPTP-induced Monkey Parkinsonism." In Neurology, 477–86. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70007-1_67.

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