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Journal articles on the topic 'Molecular sequestration'

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Author: Grafiati

Published: 14 March 2023

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1

Berendt, A. R., D. J. P. Ferguson, J. Gardner, G. Turner, A. Rowe, C. McCormick, D. Roberts, et al. "Molecular mechanisms of sequestration in malaria." Parasitology 108, S1 (March 1994): S19—S28. http://dx.doi.org/10.1017/s0031182000075685.

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Cell surface molecules have received intense attention in recent years because of the central roles they play at the interface between the external environment and the cellular interior. Their functions include adhesion to other cells or extracellular matrices, protection against hostile physical, chemical and biological agents and the transport of metabolites into and out of the cell. In addition, cell surface molecules transduce signals across the cell membrane, relaying information inwards and presenting altered characteristics to the exterior as the environment changes.

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2

Hines, P. J. "Androgen-Driven Sequestration." Science Signaling 5, no. 254 (December 11, 2012): ec320-ec320. http://dx.doi.org/10.1126/scisignal.2003853.

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3

Lal, Rattan. "Carbon sequestration." Philosophical Transactions of the Royal Society B: Biological Sciences 363, no. 1492 (August 30, 2007): 815–30. http://dx.doi.org/10.1098/rstb.2007.2185.

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Developing technologies to reduce the rate of increase of atmospheric concentration of carbon dioxide (CO 2 ) from annual emissions of 8.6 Pg C yr –1 from energy, process industry, land-use conversion and soil cultivation is an important issue of the twenty-first century. Of the three options of reducing the global energy use, developing low or no-carbon fuel and sequestering emissions, this manuscript describes processes for carbon (CO 2 ) sequestration and discusses abiotic and biotic technologies. Carbon sequestration implies transfer of atmospheric CO 2 into other long-lived global pools including oceanic, pedologic, biotic and geological strata to reduce the net rate of increase in atmospheric CO 2 . Engineering techniques of CO 2 injection in deep ocean, geological strata, old coal mines and oil wells, and saline aquifers along with mineral carbonation of CO 2 constitute abiotic techniques. These techniques have a large potential of thousands of Pg, are expensive, have leakage risks and may be available for routine use by 2025 and beyond. In comparison, biotic techniques are natural and cost-effective processes, have numerous ancillary benefits, are immediately applicable but have finite sink capacity. Biotic and abiotic C sequestration options have specific nitches, are complementary, and have potential to mitigate the climate change risks.

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4

Berndt, J. D. "No Migration Without Sequestration." Science Signaling 6, no. 300 (November 5, 2013): ec268-ec268. http://dx.doi.org/10.1126/scisignal.2004878.

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5

Alvarez-Buylla, Aurora, Cheyenne Y. Payne, Charles Vidoudez, Sunia A. Trauger, and Lauren A. O’Connell. "Molecular physiology of pumiliotoxin sequestration in a poison frog." PLOS ONE 17, no. 3 (March 11, 2022): e0264540. http://dx.doi.org/10.1371/journal.pone.0264540.

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Poison frogs bioaccumulate alkaloids for chemical defense from their arthropod diet. Although many alkaloids are accumulated without modification, some poison frog species can metabolize pumiliotoxin (PTX 251D) into the more potent allopumiliotoxin (aPTX 267A). Despite extensive research characterizing the chemical arsenal of poison frogs, the physiological mechanisms involved in the sequestration and metabolism of individual alkaloids remain unclear. We first performed a feeding experiment with the Dyeing poison frog (Dendrobates tinctorius) to ask if this species can metabolize PTX 251D into aPTX 267A and what gene expression changes are associated with PTX 251D exposure in the intestines, liver, and skin. We found that D. tinctorius can metabolize PTX 251D into aPTX 267A, and that PTX 251D exposure changed the expression level of genes involved in immune system function and small molecule metabolism and transport. To better understand the functional significance of these changes in gene expression, we then conducted a series of high-throughput screens to determine the molecular targets of PTX 251D and identify potential proteins responsible for metabolism of PTX 251D into aPTX 267A. Although screens of PTX 251D binding human voltage-gated ion channels and G-protein coupled receptors were inconclusive, we identified human CYP2D6 as a rapid metabolizer of PTX 251D in a cytochrome P450 screen. Furthermore, a CYP2D6-like gene had increased expression in the intestines of animals fed PTX, suggesting this protein may be involved in PTX metabolism. These results show that individual alkaloids can modify gene expression across tissues, including genes involved in alkaloid metabolism. More broadly, this work suggests that specific alkaloid classes in wild diets may induce physiological changes for targeted accumulation and metabolism.

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6

Lioi, Sara B., Xiang Wang, Mohammad R. Islam, Emily J. Danoff, and Douglas S. English. "Catanionic surfactant vesicles for electrostatic molecular sequestration and separation." Physical Chemistry Chemical Physics 11, no. 41 (2009): 9315. http://dx.doi.org/10.1039/b908523h.

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7

Starkov, Anatoly A. "The molecular identity of the mitochondrial Ca2+ sequestration system." FEBS Journal 277, no. 18 (July 26, 2010): 3652–63. http://dx.doi.org/10.1111/j.1742-4658.2010.07756.x.

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8

Hu, Shichao, Wei Tang, Yan Zhao, Na Li, and Feng Liu. "Ultra-specific discrimination of single-nucleotide mutations using sequestration-assisted molecular beacons." Chemical Science 8, no. 2 (2017): 1021–26. http://dx.doi.org/10.1039/c6sc03048c.

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9

Coleman, Stewart M., Alan R. Prescott, and Judith E. Sleeman. "Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1." Biochemical Journal 458, no. 2 (February 14, 2014): 267–80. http://dx.doi.org/10.1042/bj20130870.

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Sequestration of the alternative splicing factor MBNL1 in RNA foci is implicated in causing DM1. In eye lens cells from patients with DM1, MBNL1 sequestration to RNA foci appears not to be a major pathological event. MBNL1 does, however, show clear changes in subcellular distribution related to transcriptional activity and differentiation.

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10

Cho, Eun-Young, Dong-Im Cho, Jae H. Park, Hitoshi Kurose, Marc G. Caron, and Kyeong-Man Kim. "Roles of Protein Kinase C and Actin-Binding Protein 280 in the Regulation of Intracellular Trafficking of Dopamine D3 Receptor." Molecular Endocrinology 21, no. 9 (September 1, 2007): 2242–54. http://dx.doi.org/10.1210/me.2007-0202.

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Abstract D3 dopamine receptor (D3R) is expressed mainly in parts of the brain that control the emotional behaviors. It is believed that the improper regulation of D3R is involved in the etiology of schizophrenia. Desensitization of D3R is weakly associated with G protein-coupled receptor kinase (GRK)/β-arrestin-directed internalization. This suggests that there might be an alternative pathway that regulates D3R signaling. This report shows that D3R undergoes robust protein kinase C (PKC)-dependent sequestration that is accompanied by receptor phosphorylation and the desensitization of signaling. PKC-dependent D3R sequestration, which was enhanced by PKC-β or -δ, was dynamin dependent but independent of GRK, β-arrestin, or caveolin 1. Site-directed mutagenesis of all possible phosphorylation sites within the intracellular loops of D3R identified serine residues at positions 229 and 257 as the critical amino acids responsible for phorbol-12-myristate-13-acetate (PMA)-induced D3R phosphorylation, sequestration, and desensitization. In addition, the LxxY endocytosis motif, which is located between residues 252 and 255, was found to play accommodating roles for PMA-induced D3R sequestration. A continuous interaction with the actin-binding protein 280 (filamin A), which was previously known to interact with D3R, is required for PMA-induced D3R sequestration. In conclusion, the PKC-dependent but GRK-/β-arrestin-independent phosphorylation of D3R is the main pathway responsible for the sequestration and desensitization of D3R. Filamin A is essential for both the efficient signaling and sequestration of D3R.

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11

Kraus-Friedmann, N. "Calcium sequestration in the liver." Cell Calcium 11, no. 10 (November 1990): 625–40. http://dx.doi.org/10.1016/0143-4160(90)90017-o.

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12

Lenton, S., T. Seydel, T. Nylander, C. Holt, M. Härtlein, S. Teixeira, and G. Zaccai. "Dynamic footprint of sequestration in the molecular fluctuations of osteopontin." Journal of The Royal Society Interface 12, no. 110 (September 2015): 20150506. http://dx.doi.org/10.1098/rsif.2015.0506.

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The sequestration of calcium phosphate by unfolded proteins is fundamental to the stabilization of biofluids supersaturated with respect to hydroxyapatite, such as milk, blood or urine. The unfolded state of osteopontin (OPN) is thought to be a prerequisite for this activity, which leads to the formation of core–shell calcium phosphate nanoclusters. We report on the structures and dynamics of a native OPN peptide from bovine milk, studied by neutron spectroscopy and small-angle X-ray and neutron scattering. The effects of sequestration are quantified on the nanosecond– ångström resolution by elastic incoherent neutron scattering. The molecular fluctuations of the free phosphopeptide are in agreement with a highly flexible protein. An increased resilience to diffusive motions of OPN is corroborated by molecular fluctuations similar to those observed for globular proteins, yet retaining conformational flexibilities. The results bring insight into the modulation of the activity of OPN and phosphopeptides with a role in the control of biomineralization. The quantification of such effects provides an important handle for the future design of new peptides based on the dynamics–activity relationship.

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13

Fried, Michael G., and Gang Liu. "Molecular sequestration stabilizes CAP–DNA complexes during polyacrylamide gel electrophoresis." Nucleic Acids Research 22, no. 23 (1994): 5054–59. http://dx.doi.org/10.1093/nar/22.23.5054.

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14

Lavendomme, Roy, Daniela Ajami, Steven Moerkerke, Johan Wouters, Kari Rissanen, Michel Luhmer, and Ivan Jabin. "Encapsulation and solid state sequestration of gases by calix[6]arene-based molecular containers." Chemical Communications 53, no. 48 (2017): 6468–71. http://dx.doi.org/10.1039/c7cc03078a.

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15

Ma, Xueyan, Xiaoning Liu, Bangdong Xiang, and Wenjie Zhang. "Effect of Hydraulic Retention Time on Carbon Sequestration during the Two-Stage Anammox Process." Processes 7, no. 10 (October 9, 2019): 717. http://dx.doi.org/10.3390/pr7100717.

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In a biological treatment process, hydraulic retention time (HRT) has a certain effect on the operation of the reactor. This study investigated the effect of HRT on carbon sequestration in a two-stage anaerobic ammonium oxidation (anammox) process using a partial nitrification reactor and anammox reactor to determine the optimal carbon sequestration operating conditions. Molecular biotechnology was used to analyze the sludge in the reactor in order to explore the denitrification performance and to determine the carbon sequestration pathway of the microorganisms. The results show that the partial nitrification stage had the highest carbon sequestration rate (0.319 mg/mg·N) when the nitrogen loading rate (NLR) was 0.44 kg·N/m3/d. The NLR of the anammox stage was 0.13 kg·N/m3/d. When the HRT was 33.4 h, the carbon sequestration of the anammox reaction was at its highest, reaching 0.183 mg/mg·N. The results of microbial analysis show that the carbon-fixing gene cbbLR1 was present in the sludge samples during the anammox and partial nitrification stages, and that there was a Calvin cycle carbon sequestration pathway during the growth process. However, the existence of a gene for reducing and immobilizing CO2 by the acetyl-CoA pathway was not detected; further research is thus needed.

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16

Burger, Herman, Alexander T. den Dekker, Sandra Segeletz, Antonius W. M. Boersma, Peter de Bruijn, Maria Debiec-Rychter, Takahiro Taguchi, et al. "Lysosomal Sequestration Determines Intracellular Imatinib Levels." Molecular Pharmacology 88, no. 3 (June 24, 2015): 477–87. http://dx.doi.org/10.1124/mol.114.097451.

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17

Riber, Leise, and Anders Løbner-Olesen. "Coordinated Replication and Sequestration of oriC and dnaA Are Required for Maintaining Controlled Once-per-Cell-Cycle Initiation in Escherichia coli." Journal of Bacteriology 187, no. 16 (August 15, 2005): 5605–13. http://dx.doi.org/10.1128/jb.187.16.5605-5613.2005.

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ABSTRACT Escherichia coli cells were constructed in which the dnaA gene was moved to a location opposite oriC on the circular chromosome. In these cells the dnaA gene was replicated with significant delay relative to the origin. Consequently, the period where the newly replicated and hemimethylated oriC was sequestered no longer coincided with the period where the dnaA gene promoter was sequestered. DnaA protein synthesis was therefore expected to continue during origin sequestration. Despite a normal length of the sequestration period in such cells, they had increased origin content and also displayed asynchrony of initiation. This indicated that reinitiation occasionally occurred at some origins within the same cell cycle. The extra initiations took place in spite of a reduction in total DnaA protein concentration to about half of the wild-type level. We propose that this more efficient utilization of DnaA protein results from an increased availability at the end of the origin sequestration period. Therefore, coordinated sequestration of oriC and dnaA is required for maintaining controlled once-per-cell-cycle initiation.

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18

Banks, William A., Priyanka Sharma, Kim M. Hansen, Nils Ludwig, and Theresa L. Whiteside. "Characteristics of Exosomes and the Vascular Landscape Regulate Exosome Sequestration by Peripheral Tissues and Brain." International Journal of Molecular Sciences 23, no. 20 (October 19, 2022): 12513. http://dx.doi.org/10.3390/ijms232012513.

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Exosomes mediate intercellular communication, shuttling messages between cells and tissues. We explored whether exosome tissue sequestration is determined by the exosomes or the tissues using ten radiolabeled exosomes from human or murine, cancerous or noncancerous cell lines. We measured sequestration of these exosomes by the liver, kidney, spleen, and lung after intravenous injection into male CD-1 mice. Except for kidney sequestration of three exosomes, all exosomes were incorporated by all tissues, but sequestration levels varied greatly among exosomes and tissues. Species of origin (mouse vs. human) or source (cancerous vs. noncancerous cells) did not influence tissue sequestration. Sequestration of J774A.1 exosomes by liver involved the mannose-6 phosphate (M6P) receptor. Wheatgerm agglutinin (WGA) or lipopolysaccharide (LPS) treatments enhanced sequestration of exosomes by brain and lung but inhibited sequestration by liver and spleen. Response to LPS was not predictive of response to WGA. Path and heat map analyses included our published results for brain and found distinct clusters among the exosomes and the tissues. In conclusion, we found no evidence for a universal binding site controlling exosome-tissue interactions. Instead, sequestration of exosomes by tissues is differentially regulated by both exosomes and tissues and may be stimulated or inhibited by WGA and inflammation.

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19

Ma, Long, Guanrong Wu, Yufeng Li, Ping Qin, Lingpei Meng, Haiyan Liu, Yuyin Li, and Aipo Diao. "A reversible metal ion fueled DNA three-way junction molecular device for “turn-on and -off” fluorescence detection of mercury ions (II) and biothiols respectively with high selectivity and sensitivity." Nanoscale 7, no. 43 (2015): 18044–48. http://dx.doi.org/10.1039/c5nr04688b.

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20

Choudhury, Sharmila, Michael R. Wilson, Michael E. Goddard, Kieran P. O'Dea, and Masao Takata. "Mechanisms of early pulmonary neutrophil sequestration in ventilator-induced lung injury in mice." American Journal of Physiology-Lung Cellular and Molecular Physiology 287, no. 5 (November 2004): L902—L910. http://dx.doi.org/10.1152/ajplung.00187.2004.

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Polymorphonuclear leukocytes (PMN) play an important role in ventilator-induced lung injury (VILI), but the mechanisms of pulmonary PMN recruitment, particularly early intravascular PMN sequestration during VILI, have not been elucidated. We investigated the physiological and molecular mechanisms of pulmonary PMN sequestration in an in vivo mouse model of VILI. Anesthetized C57/BL6 mice were ventilated for 1 h with high tidal volume (injurious ventilation), low tidal volume and high positive end-expiratory pressure (protective ventilation), or normal tidal volume (control ventilation). Pulmonary PMN sequestration analyzed by flow cytometry of lung cell suspensions was substantially enhanced in injurious ventilation compared with protective and control ventilation, preceding development of physiological signs of lung injury. Anesthetized, spontaneously breathing mice with continuous positive airway pressure demonstrated that raised alveolar pressure alone does not induce PMN entrapment. In vitro leukocyte deformability assay indicated stiffening of circulating leukocytes in injurious ventilation compared with control ventilation. PMN sequestration in injurious ventilation was markedly inhibited by administration of anti-L-selectin antibody, but not by anti-CD18 antibody. These results suggest that mechanical ventilatory stress initiates pulmonary PMN sequestration early in the course of VILI, and this phenomenon is associated with stretch-induced inflammatory events leading to PMN stiffening and mediated by L-selectin-dependent but CD18-independent mechanisms.

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21

Chinopoulos, Christos, and Vera Adam-Vizi. "Mitochondrial Ca2+ sequestration and precipitation revisited." FEBS Journal 277, no. 18 (July 26, 2010): 3637–51. http://dx.doi.org/10.1111/j.1742-4658.2010.07755.x.

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22

Trapaidze, Nino, Duane E. Keith, Svetlana Cvejic, Christopher J. Evans, and Lakshmi A. Devi. "Sequestration of the δ Opioid Receptor." Journal of Biological Chemistry 271, no. 46 (November 15, 1996): 29279–85. http://dx.doi.org/10.1074/jbc.271.46.29279.

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23

Beynon, R. J., and J. S. Bond. "Catabolism of intracellular protein: molecular aspects." American Journal of Physiology-Cell Physiology 251, no. 2 (August 1, 1986): C141—C152. http://dx.doi.org/10.1152/ajpcell.1986.251.2.c141.

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All living cells regulate the content and composition of their resident proteins, but the mechanisms by which this is accomplished are not understood. The process of protein degradation has an important role in determining steady state and fluctuations of protein concentrations in mammalian cells. This process may be regulated by innate properties of the protein substrates, by factors that interact or "brand" proteins for degradation or by the degradative machinery of the cell. For a specific protein, there appears to be a committed step, an irreversible event that leads to rapid and extensive degradation. That initial event may or may not involve 1) proteolysis, 2) a nonproteolytic covalent modification or branding event (e.g., oxidation, ubiquitin conjugation), 3) denaturation or unfolding of the protein, or 4) sequestration. The degradative machinery of cells may either recognize proteins committed to degradation or initiate degradation, but the process must be selective because there is great heterogeneity in the rates of degradation for different proteins of one cell. The degradative process certainly requires proteases, and it is probable that lysosomal and extralysosomal proteases are involved in the catabolism of cellular proteins. We review here briefly what is currently known about the factors that may determine the half-life of a protein in a mammalian cell, the role of the protein substrate and sequestration in the process, the proteolytic and nonproteolytic enzymes that may initiate the degradative process, and the regulation of extensive degradation of proteins in cells.

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24

Sodeik, Beate, Klaudia Brix, and Wilhelm Stockem. "Sequestration of microinjected molecular probes from the cytoplasm of Amoeba proteus." European Journal of Protistology 25, no. 1 (September 1989): 75–84. http://dx.doi.org/10.1016/s0932-4739(89)80080-x.

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25

Yin, Bohan, Kin Hei Kelvin Li, Lok Wai Cola Ho, Cecilia Ka Wing Chan, and Chung Hang Jonathan Choi. "Toward Understanding in Vivo Sequestration of Nanoparticles at the Molecular Level." ACS Nano 12, no. 3 (February 27, 2018): 2088–93. http://dx.doi.org/10.1021/acsnano.8b00141.

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26

MORGAN, A. JOHN, STEPHEN R. STÜRZENBAUM, CAROLE WINTERS, and PETER KILLE. "Cellular and molecular aspects of metal sequestration and toxicity in earthworms." Invertebrate Reproduction & Development 36, no. 1-3 (September 1999): 17–24. http://dx.doi.org/10.1080/07924259.1999.9652673.

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27

Heffelfinger, Grant S., Anthony Martino, Andrey Gorin, Ying Xu, Mark D. Rintoul, Al Geist, Hashim M. Al-Hashimi, et al. "Carbon Sequestration in Synechococcus Sp.: From Molecular Machines to Hierarchical Modeling." OMICS: A Journal of Integrative Biology 6, no. 4 (October 2002): 305–30. http://dx.doi.org/10.1089/153623102321112746.

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28

Olsson, Jan, Santanu Dasgupta, Otto G. Berg, and Kurt Nordström. "Eclipse period without sequestration in Escherichia coli." Molecular Microbiology 44, no. 6 (June 18, 2002): 1429–40. http://dx.doi.org/10.1046/j.1365-2958.2002.02954.x.

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29

RINDYASTUTI, RIDESTI, DIAH RACHMAWATI, RETNO PENI SANCAYANINGSIH, and TITUT YULISTYARINI. "Ecophysiological and growth characters of ten woody plant species in determining their carbon sequestration." Biodiversitas Journal of Biological Diversity 19, no. 2 (March 1, 2018): 610–19. http://dx.doi.org/10.13057/biodiv/d190238.

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Rindyastuti R, Rachmawati D, Sancayaningsih RP, Yulistyarini T. 2018. Ecophysiological and growth characters of ten woody plant species in determining their carbon sequestration. Biodiversitas 19: 610-619. Tree planting and ecosystem restoration is one of mitigation program of global climate change scheme to reduce CO2 in the atmosphere by sequestering carbon. Carbon storage in the living plant varies among species due to ecophysiological and growth characters of their photosynthesis. Ecophysiological properties of tropical plant species related to carbon sequestration was lack of investigation. The study in this area will be the significant knowledge contribution to C-sink project especially species-level management which has been agreed globally and nationally. The objectives of this research were to study the ecophysiological and growth factors affecting carbon sequestration and to select plant species with high carbon sequestration using 16 months-old-seedling of ten woody plant species. Biomass, carbon storage, the whole plant photosynthetic capacity, total chlorophyll content, stomatal index, and Leaf Area Index (LAI) were significantly different among species. The LAI, total chlorophyll content, whole plant photosynthetic capacity, stem height and stem diameter were positively correlated to biomass and carbon storage. Multivariate correlation test (P>0.05) revealed that the total of chlorophyll content was the ecophysiological factor most contributes to carbon sequestration. The total of chlorophyll content correlates to the stem height, while the whole plant photosynthesis correlates to leaf area in determining plant carbon sequestration. Moreover, two mangrove species, H. littoralis and B. asiatica have the highest carbon sequestration among species studied. For priority in tree planting program in dry lowland habitats, the local species, i.e., S. cumini and D. discolor were more recommended than any others species observed in this study.

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Rodriguez, Jason J., Lin-Fa Wang, and Curt M. Horvath. "Hendra Virus V Protein Inhibits Interferon Signaling by Preventing STAT1 and STAT2 Nuclear Accumulation." Journal of Virology 77, no. 21 (November 1, 2003): 11842–45. http://dx.doi.org/10.1128/jvi.77.21.11842-11845.2003.

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ABSTRACT The V protein of the recently emerged paramyxovirus, Nipah virus, has been shown to inhibit interferon (IFN) signal transduction through cytoplasmic sequestration of cellular STAT1 and STAT2 in high-molecular-weight complexes. Here we demonstrate that the closely related Hendra virus V protein also inhibits cellular responses to IFN through binding and cytoplasmic sequestration of both STAT1 and STAT2, but not STAT3. These findings demonstrate a V protein-mediated IFN signal evasion mechanism that is a general property of the known Henipavirus species.

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31

Gulliver, Djuna M., Gregory V. Lowry, and Kelvin B. Gregory. "CO2concentration and pH alters subsurface microbial ecology at reservoir temperature and pressure." RSC Adv. 4, no. 34 (2014): 17443–53. http://dx.doi.org/10.1039/c4ra02139h.

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Molecular ecology techniques are utilized to determine the impact of CO₂concentrations on microbial communities under reservoir temperature and pressure simulating geological carbon sequestration.

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BROWN, G. M., E. DROST, C. SELBY, K. DONALDSON, and W. MacNEE. "Neutrophil Sequestration in Rat Lungs." Annals of the New York Academy of Sciences 624, no. 1 (May 1991): 316–17. http://dx.doi.org/10.1111/j.1749-6632.1991.tb17031.x.

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33

GOLDGABER, D., A. I. SCHWARZMAN, R. BHASIN, L. GREGORI, D. SCHMECHEL, A. M. SAUNDERS, A. D. ROSES, and W. J. STRITTMATTER. "Sequestration of Amyloid β-Peptidea." Annals of the New York Academy of Sciences 695, no. 1 (September 1993): 139–43. http://dx.doi.org/10.1111/j.1749-6632.1993.tb23042.x.

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34

Zhou, Wenning, Zhe Zhang, Haobo Wang, and Xu Yang. "Molecular Investigation of CO2/CH4 Competitive Adsorption and Confinement in Realistic Shale Kerogen." Nanomaterials 9, no. 12 (November 20, 2019): 1646. http://dx.doi.org/10.3390/nano9121646.

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The adsorption behavior and the mechanism of a CO2/CH4 mixture in shale organic matter play significant roles to predict the carbon dioxide sequestration with enhanced gas recovery (CS-EGR) in shale reservoirs. In the present work, the adsorption performance and the mechanism of a CO2/CH4 binary mixture in realistic shale kerogen were explored by employing grand canonical Monte Carlo (GCMC) and molecular dynamics (MD) simulations. Specifically, the effects of shale organic type and maturity, temperature, pressure, and moisture content on pure CH4 and the competitive adsorption performance of a CO2/CH4 mixture were investigated. It was found that pressure and temperature have a significant influence on both the adsorption capacity and the selectivity of CO2/CH4. The simulated results also show that the adsorption capacities of CO2/CH4 increase with the maturity level of kerogen. Type II-D kerogen exhibits an obvious superiority in the adsorption capacity of CH4 and CO2 compared with other type II kerogen. In addition, the adsorption capacities of CO2 and CH4 are significantly suppressed in moist kerogen due to the strong adsorption strength of H2O molecules on the kerogen surface. Furthermore, to characterize realistic kerogen pore structure, a slit-like kerogen nanopore was constructed. It was observed that the kerogen nanopore plays an important role in determining the potential of CO2 subsurface sequestration in shale reservoirs. With the increase in nanopore size, a transition of the dominated gas adsorption mechanism from micropore filling to monolayer adsorption on the surface due to confinement effects was found. The results obtained in this study could be helpful to estimate original gas-in-place and evaluate carbon dioxide sequestration capacity in a shale matrix.

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35

Fu, Lianwu, and Elizabeth Sztul. "Traffic-independent function of the Sar1p/COPII machinery in proteasomal sorting of the cystic fibrosis transmembrane conductance regulator." Journal of Cell Biology 160, no. 2 (January 20, 2003): 157–63. http://dx.doi.org/10.1083/jcb.200210086.

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Newly synthesized proteins that do not fold correctly in the ER are targeted for ER-associated protein degradation (ERAD) through distinct sorting mechanisms; soluble ERAD substrates require ER-Golgi transport and retrieval for degradation, whereas transmembrane ERAD substrates are retained in the ER. Retained transmembrane proteins are often sequestered into specialized ER subdomains, but the relevance of such sequestration to proteasomal degradation has not been explored. We used the yeast Saccharomyces cerevisiae and a model ERAD substrate, the cystic fibrosis transmembrane conductance regulator (CFTR), to explore whether CFTR is sequestered before degradation, to identify the molecular machinery regulating sequestration, and to analyze the relationship between sequestration and degradation. We report that CFTR is sequestered into ER subdomains containing the chaperone Kar2p, and that sequestration and CFTR degradation are disrupted in sec12ts strain (mutant in guanine-nucleotide exchange factor for Sar1p), sec13ts strain (mutant in the Sec13p component of COPII), and sec23ts strain (mutant in the Sec23p component of COPII) grown at restrictive temperature. The function of the Sar1p/COPII machinery in CFTR sequestration and degradation is independent of its role in ER-Golgi traffic. We propose that Sar1p/COPII-mediated sorting of CFTR into ER subdomains is essential for its entry into the proteasomal degradation pathway. These findings reveal a new aspect of the degradative mechanism, and suggest functional crosstalk between the secretory and the degradative pathways.

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36

Hirose, Tetsuro, Giorgio Virnicchi, Akie Tanigawa, Takao Naganuma, Ruohan Li, Hiroshi Kimura, Takahide Yokoi, et al. "NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies." Molecular Biology of the Cell 25, no. 1 (January 2014): 169–83. http://dx.doi.org/10.1091/mbc.e13-09-0558.

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Paraspeckles are subnuclear structures formed around nuclear paraspeckle assembly transcript 1 (NEAT1)/MENε/β long noncoding RNA (lncRNA). Here we show that paraspeckles become dramatically enlarged after proteasome inhibition. This enlargement is mainly caused by NEAT1 transcriptional up-regulation rather than accumulation of undegraded paraspeckle proteins. Of interest, however, using immuno–electron microscopy, we find that key paraspeckle proteins become effectively depleted from the nucleoplasm by 50% when paraspeckle assembly is enhanced, suggesting a sequestration mechanism. We also perform microarrays from NEAT1-knockdown cells and find that NEAT1 represses transcription of several genes, including the RNA-specific adenosine deaminase B2 (ADARB2) gene. In contrast, the NEAT1-binding paraspeckle protein splicing factor proline/glutamine-rich (SFPQ) is required for ADARB2 transcription. This leads us to hypothesize that ADARB2 expression is controlled by NEAT1-dependent sequestration of SFPQ. Accordingly, we find that ADARB2 expression is strongly reduced upon enhanced SFPQ sequestration by proteasome inhibition, with concomitant reduction in SFPQ binding to the ADARB2 promoter. Finally, NEAT1−/− fibroblasts are more sensitive to proteasome inhibition, which triggers cell death, suggesting that paraspeckles/NEAT1 attenuates the cell death pathway. These data further confirm that paraspeckles are stress-responsive nuclear bodies and provide a model in which induced NEAT1 controls target gene transcription by protein sequestration into paraspeckles.

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Burns, Mark R., Scott A. Jenkins, Matthew R. Kimbrell, Rajalakshmi Balakrishna, Thuan B. Nguyen, Benjamin G. Abbo, and Sunil A. David. "Polycationic Sulfonamides for the Sequestration of Endotoxin." Journal of Medicinal Chemistry 50, no. 4 (February 2007): 877–88. http://dx.doi.org/10.1021/jm061198m.

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Chang, Chin-Yuan, Xiaohui Yan, Ivana Crnovcic, Thibault Annaval, Changsoo Chang, Boguslaw Nocek, Jeffrey D. Rudolf, et al. "Resistance to Enediyne Antitumor Antibiotics by Sequestration." Cell Chemical Biology 25, no. 9 (September 2018): 1075–85. http://dx.doi.org/10.1016/j.chembiol.2018.05.012.

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39

Teng, Wei, Nan Bai, Jianwei Fan, Dandan Li, Rui Liu, Jianping Yang, Wei-xian Zhang, and Dongyuan Zhao. "Enhanced sequestration of large-sized dissolved organic micropollutants in polymeric membranes incorporated with mesoporous carbon." RSC Advances 6, no. 85 (2016): 81477–84. http://dx.doi.org/10.1039/c6ra17570h.

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Hybrid polyvinylidene fluoride membrane incorporated with mesoporous carbon is fabricated for an enhanced sequestration of large-molecular-sized microcystin-LR and Rhodamine B (3.8 and 14.8 mg g⁻¹, respectively).

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40

Bluthgen, Nils, Frank J. Bruggeman, Stefan Legewie, Hanspeter Herzel, Hans V. Westerhoff, and Boris N. Kholodenko. "Effects of sequestration on signal transduction cascades." FEBS Journal 273, no. 5 (March 2006): 895–906. http://dx.doi.org/10.1111/j.1742-4658.2006.05105.x.

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41

Naseeb, Uzma, Shamshad Zarina, Theres Jägerbrink, Jawed Shafqat, Hans Jörnvall, and Jonas Axelsson. "Differential hemoglobin A sequestration between hemodialysis modalities." Biomolecular Concepts 8, no. 2 (May 24, 2017): 125–29. http://dx.doi.org/10.1515/bmc-2017-0006.

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AbstractThis report evaluates plasma protein patterns, dialysates and protein analysis of used dialysis membranes from the same patient under hemodialysis in three separate modalities, using high-flux membranes in concentration-driven transport (HD), convection-driven hemofiltration (HF) and combined hemodialfiltration (HDF). The plasma protein changes induced by each of the three dialysis modalities showed small differences in proteins identified towards our previous plasma analyses of chronic kidney disease (CKD) patients. The used dialysate peptide concentrations likewise exhibited small differences among the modalities and varied in the same relative order as the plasma changes, with protein losses in the order HD>HDF>HF. The membrane protein deposits allowed quantification of the relative Hb removal ratios as ~1.7 for HD and ~1.2 for HDF vs. ~1.0 for HF. Hence, plasma protein alterations, dialysate peptide contents and membrane Hb deposits all identify HD as the modality with the most extensive filtration results and exemplifies the accessibility of protein analysis of used membrane filters for evaluation of dialysis efficiencies.

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Jockers, Ralf, Angelo Da Silva, A. Donny Strosberg, Michel Bouvier, and Stefano Marullo. "New Molecular and Structural Determinants Involved in -Adrenergic Receptor Desensitization and Sequestration." Journal of Biological Chemistry 271, no. 16 (April 19, 1996): 9355–62. http://dx.doi.org/10.1074/jbc.271.16.9355.

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43

Luft, Charles M., Elango Munusamy, Jeanne E. Pemberton, and Steven D. Schwartz. "Molecular Dynamics Simulation of the Oil Sequestration Properties of a Nonionic Rhamnolipid." Journal of Physical Chemistry B 122, no. 14 (March 16, 2018): 3944–52. http://dx.doi.org/10.1021/acs.jpcb.7b11959.

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44

Yuan, Lei, Yi Zhang, Jiafei Zhao, Yongchen Song, and Yuan Chi. "Molecular simulation of equal density temperature in CCS under geological sequestration conditions." Greenhouse Gases: Science and Technology 10, no. 1 (September 30, 2019): 90–102. http://dx.doi.org/10.1002/ghg.1929.

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45

Christenson, Jan T., and Azu Owunwanne. "Leucocyte sequestration in endotoxemia and the effect of low-molecular-weight dextran." European Journal of Nuclear Medicine 17, no. 1-2 (January 1990): 28–33. http://dx.doi.org/10.1007/bf00819400.

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46

Purushotham, Gorla, Krishna B. Sarva, Ewelina Blaszczyk, Malini Rajagopalan, and Murty V. Madiraju. "Mycobacterium tuberculosis oriC sequestration by MtrA response regulator." Molecular Microbiology 98, no. 3 (August 31, 2015): 586–604. http://dx.doi.org/10.1111/mmi.13144.

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47

Lamaze, C., T. Baba, T. E. Redelmeier, and S. L. Schmid. "Recruitment of epidermal growth factor and transferrin receptors into coated pits in vitro: differing biochemical requirements." Molecular Biology of the Cell 4, no. 7 (July 1993): 715–27. http://dx.doi.org/10.1091/mbc.4.7.715.

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The biochemical requirements for epidermal growth factor (EGF) and transferrin receptor-mediated endocytosis were compared using perforated human A431 cells. Morphological studies showed that horseradish peroxidase (HRP)-conjugated EGF and gold-labeled antitransferrin (Tfn) receptor antibodies were colocalized during endocytosis in vitro. The sequestration of both ligands into deeply invaginated coated pits required ATP hydrolysis and cytosolic factors and was inhibited by GTP gamma S, indicating mechanistic similarities. Importantly, several differences in the biochemical requirements for sequestration of EGF and Tfn were also detected. These included differing requirements for soluble AP (clathrin assembly protein) complexes, differing cytosolic requirements, and differing sensitivities to the tyrosine kinase inhibitor, genistein. The biochemical differences detected between EGF and Tfn sequestration most likely reflect specific requirements for the recruitment of EGF-receptors (R) into coated pits. This assay provides a novel means to identify the molecular bases for these biochemical distinctions and to elucidate the mechanisms involved in ligand-induced recruitment of EGF-R into coated pits.

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Ngsee, J. K., A. M. Fleming, and R. H. Scheller. "A rab protein regulates the localization of secretory granules in AtT-20 cells." Molecular Biology of the Cell 4, no. 7 (July 1993): 747–56. http://dx.doi.org/10.1091/mbc.4.7.747.

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Low molecular weight (LMW) GTP-binding proteins are hypothesized to play a role in the vectorial transport of intracellular vesicles. Mutational studies in yeast and subcellular localization in mammalian cells suggest that a family of LMW GTP-binding proteins, termed rab, target intracellular vesicles to their appropriate acceptor compartment. In this report, we demonstrate that an elasmobranch homologue of rab3A, o-rab3, plays a significant role in the sequestration of regulated secretory vesicles. When transfected into the murine endocrine cell line AtT-20, the wild-type o-rab3 protein is localized exclusively to the tips of the processes, a region of the cell known to accumulate proteins associated with regulated secretory vesicles. Two mutations, Gln81 to Leu (Q81L) and Asn135 Ile (N135I), which alter GTP binding or rate of hydrolysis, blocked the localization of the o-rab3 protein to the tips of cell processes. These mutations also hindered the sequestration of ACTH-containing secretory vesicles to the process tips but did not affect the basal or stimulated release of ACTH. Moreover, the sequestration of the protein VAMP to the process tip was also hindered by the mutation. The results demonstrate a role for the rab3 proteins in localization, sequestration, and storage of secretory vesicles near their release site.

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Azijli, Kaamar, Kristy J. Gotink, and Henk M. W. Verheul. "The Potential Role of Lysosomal Sequestration in Sunitinib Resistance of Renal Cell Cancer." Journal of Kidney Cancer and VHL 2, no. 4 (January 26, 2016): 195–203. http://dx.doi.org/10.15586/jkcvhl.2015.44.

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Renal cell carcinoma (RCC) is a highly vascularized tumor type, which is often associated with inactivated mutations in the von Hippel-Lindau gene that drives proangiogenic signaling pathways. As such, new therapies for the treatment of RCC have largely been focused on blocking angiogenesis. Sunitinib, an antiangiogenic tyrosine kinase inhibitor, is the most frequently used first-line drug for the treatment of RCC. Although treatment with sunitinib improves patient outcome considerably, acquired resistance will emerge in all cases. The molecular mechanisms of resistance to sunitinib are poorly understood, but in the past decade, several of these have been proposed. Lysosomal sequestration of sunitinib was reported as a potential resistance mechanism to sunitinib. In this review, the underlying molecular mechanisms of lysosomal sunitinib sequestration and the potential strategies to overcome this resistance are discussed to be able to further improve the treatment of RCC.

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Malhas, Ashraf N., and David J. Vaux. "Transcription factor sequestration by nuclear envelope components." Cell Cycle 8, no. 7 (April 2009): 959–64. http://dx.doi.org/10.4161/cc.8.7.8092.

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