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Journal articles on the topic 'Molecular probes'

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Author: Grafiati
Published: 4 June 2021
Last updated: 30 July 2024

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1

Bubien, James K., and Dale J. Benos. "Molecular pH Probes." Circulation Research 99, no. 5 (September 2006): 453–54. http://dx.doi.org/10.1161/01.res.0000241052.33145.54.

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2

Zhang, Yujin, and Wei Hu. "Sensing Performance and Efficiency of Two Energy Transfer-Based Two-Photon Fluorescent Probes for pH." Sensors 18, no. 12 (December 13, 2018): 4407. http://dx.doi.org/10.3390/s18124407.

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The design and synthesis of fluorescent probes for monitoring pH values inside living cells have attracted great attention, due to the important role pH plays in many biological processes. In this study, the optical properties of two different two-photon fluorescent probes for pH are studied. The ratiometric sensing of the probes are theoretically illustrated. Meanwhile, the recognitional mechanisms of the probes are investigated, which shows the energy transfer process when react with H+. Specially, the calculated results demonstrate that Probe1 possesses a higher energy transfer efficiency and a larger two-photon absorption cross-section than Probe2, indicating it to be a preferable pH fluorescent probe. Therefore, the influence of connection between the donor and the acceptor on the sensing performances of the probe is demonstrated. Our results help to understand the experimental observations and provide a theoretical basis to synthesize efficient two-photon fluorescent probes for monitoring pH changes.
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3

Mahmood, U., and L. Josephson. "Molecular MR Imaging Probes." Proceedings of the IEEE 93, no. 4 (April 2005): 800–808. http://dx.doi.org/10.1109/jproc.2005.844264.

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4

Strack, Rita. "Probes for molecular crowding." Nature Methods 15, no. 8 (July 31, 2018): 570. http://dx.doi.org/10.1038/s41592-018-0098-8.

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5

Diwu, Zhenjun, Cailan Zhang, Dieter H. Klaubert, and Richard P. Haugland. "Fluorescent molecular probes VI." Journal of Photochemistry and Photobiology A: Chemistry 131, no. 1-3 (February 2000): 95–100. http://dx.doi.org/10.1016/s1010-6030(99)00240-3.

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6

Butler, John E. "Molecular probes and immunodiagnostics." Veterinary Immunology and Immunopathology 35 (February 1993): 205–12. http://dx.doi.org/10.1016/0165-2427(93)90150-3.

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7

Wood, EJ. "Molecular probes: Handbook of fluorescent probes and research chemicals." Biochemical Education 22, no. 2 (April 1994): 83. http://dx.doi.org/10.1016/0307-4412(94)90083-3.

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8

Kele, Péter. "Advanced molecular (bio)probes—probes that are good, better, smarter." Methods and Applications in Fluorescence 3, no. 4 (September 8, 2015): 040201. http://dx.doi.org/10.1088/2050-6120/3/4/040201.

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9

Barakat, Sarah, Melike Berksöz, Pegah Zahedimaram, Sofia Piepoli, and Batu Erman. "Nanobodies as molecular imaging probes." Free Radical Biology and Medicine 182 (March 2022): 260–75. http://dx.doi.org/10.1016/j.freeradbiomed.2022.02.031.

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10

Nagano, T. "Molecular design of bioimaging probes." Seibutsu Butsuri 43, supplement (2003): S15. http://dx.doi.org/10.2142/biophys.43.s15_2.

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11

Huang, Zhen, and Roman Boulatov. "Chemomechanics with molecular force probes." Pure and Applied Chemistry 82, no. 4 (March 31, 2010): 931–51. http://dx.doi.org/10.1351/pac-con-09-11-36.

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Chemomechanics is an emerging area at the interface of chemistry, materials science, physics, and biology that aims at quantitative understanding of reaction dynamics in multiscale phenomena. These are characterized by correlated directional motion at multiple length scales—from molecular to macroscopic. Examples include reactions in stressed materials, in shear flows, and at propagating interfaces, the operation of motor proteins, ion pumps, and actuating polymers, and mechanosensing. To explain the up to 1015-fold variations in reaction rates in multiscale phenomena—which are incompatible within the standard models of chemical kinetics—chemomechanics relies on the concept of molecular restoring force. Molecular force probes are inert molecules that allow incremental variations in restoring forces of diverse reactive moieties over hundreds of piconewtons (pN). Extending beyond the classical studies of reactions of strained molecules, molecular force probes enable experimental explorations of how reaction rates and restoring forces are related. In this review, we will describe the utility of one such probe—stiff stilbene. Various reactive moieties were incorporated in inert linkers that constrained stiff stilbene to highly strained macrocycles. Such series provided the first direct experimental validation of the most popular chemomechanical model, demonstrated its predictive capabilities, and illustrated the diversity of relationships between reaction rates and forces.
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12

Cabot, Rafel, and Christopher A. Hunter. "Molecular probes of solvation phenomena." Chemical Society Reviews 41, no. 9 (2012): 3485. http://dx.doi.org/10.1039/c2cs15287h.

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13

Jacobson., Kenneth A., Daniel L., Boring Xiao-duo Ji, William Barrington, Vickram Ramkumar, and Gary L. Stiles. "Molecular Probes for Adenosine Receptors." Japanese Journal of Pharmacology 52 (1990): 8. http://dx.doi.org/10.1016/s0021-5198(19)32889-6.

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14

Zhang, Shaohua, Ling Wen, Caixia Sun, and Zhen Li. "Ultrasmall inorganic molecular imaging probes." Nanomedicine: Nanotechnology, Biology and Medicine 14, no. 5 (July 2018): 1786. http://dx.doi.org/10.1016/j.nano.2017.11.132.

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15

Liang, Grace, and Patricia K. Nguyen. "Molecular probes for cardiovascular imaging." Journal of Nuclear Cardiology 23, no. 4 (May 17, 2016): 783–89. http://dx.doi.org/10.1007/s12350-016-0501-8.

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16

Kim, Sung Bae, and Rika Fujii. "Fabrication of molecular tension probes." MethodsX 3 (2016): 261–67. http://dx.doi.org/10.1016/j.mex.2016.03.008.

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17

Wu, Song, Edwin Chang, and Zhen Cheng. "Molecular Probes for Bioluminescence Imaging." Current Organic Synthesis 8, no. 4 (August 1, 2011): 488–97. http://dx.doi.org/10.2174/157017911796117188.

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18

Meyer, E., and T. Glatzel. "Novel Probes for Molecular Electronics." Science 324, no. 5933 (June 11, 2009): 1397–98. http://dx.doi.org/10.1126/science.1175869.

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19

Zhang, Shaohua, Ling Wen, Caixia Sun, and Zhen Li. "Ultrasmall inorganic molecular imaging probes." Journal of Controlled Release 259 (August 2017): e189. http://dx.doi.org/10.1016/j.jconrel.2017.03.371.

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20

Kele, Péter. "Focus on advanced molecular (bio)probes—probes that aregood, better, smarter." Methods and Applications in Fluorescence 4, no. 1 (December 24, 2015): 010401. http://dx.doi.org/10.1088/2050-6120/4/1/010401.

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21

Lu, Sha, Zhiqi Dai, Yunxi Cui, and De-Ming Kong. "Recent Development of Advanced Fluorescent Molecular Probes for Organelle-Targeted Cell Imaging." Biosensors 13, no. 3 (March 8, 2023): 360. http://dx.doi.org/10.3390/bios13030360.

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Fluorescent molecular probes are very powerful tools that have been generally applied in cell imaging in the research fields of biology, pathology, pharmacology, biochemistry, and medical science. In the last couple of decades, numerous molecular probes endowed with high specificity to particular organelles have been designed to illustrate intracellular images in more detail at the subcellular level. Nowadays, the development of cell biology has enabled the investigation process to go deeply into cells, even at the molecular level. Therefore, probes that can sketch a particular organelle’s location while responding to certain parameters to evaluate intracellular bioprocesses are under urgent demand. It is significant to understand the basic ideas of organelle properties, as well as the vital substances related to each unique organelle, for the design of probes with high specificity and efficiency. In this review, we summarize representative multifunctional fluorescent molecular probes developed in the last decade. We focus on probes that can specially target nuclei, mitochondria, endoplasmic reticulums, and lysosomes. In each section, we first briefly introduce the significance and properties of different organelles. We then discuss how probes are designed to make them highly organelle-specific. Finally, we also consider how probes are constructed to endow them with additional functions to recognize particular physical/chemical signals of targeted organelles. Moreover, a perspective on the challenges in future applications of highly specific molecular probes in cell imaging is also proposed. We hope that this review can provide researchers with additional conceptual information about developing probes for cell imaging, assisting scientists interested in molecular biology, cell biology, and biochemistry to accelerate their scientific studies.
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22

Schreiber, Cynthia L., and Bradley D. Smith. "Molecular Imaging of Aminopeptidase N in Cancer and Angiogenesis." Contrast Media & Molecular Imaging 2018 (June 25, 2018): 1–15. http://dx.doi.org/10.1155/2018/5315172.

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This review focuses on recent advances in the molecular imaging of aminopeptidase N (APN, also known as CD13), a zinc metalloenzyme that cleaves N-terminal neutral amino acids. It is overexpressed in multiple cancer types and also on the surface of vasculature undergoing angiogenesis, making it a promising target for molecular imaging and targeted therapy. Molecular imaging probes for APN are divided into two large subgroups: reactive and nonreactive. The structures of the reactive probes (substrates) contain a reporter group that is cleaved and released by the APN enzyme. The nonreactive probes are not cleaved by the enzyme and contain an antibody, peptide, or nonpeptide for targeting the enzyme exterior or active site. Multivalent homotopic probes utilize multiple copies of the same targeting unit, whereas multivalent heterotopic molecular probes are equipped with different targeting units for different receptors. Several recent preclinical cancer imaging studies have shown that multivalent APN probes exhibit enhanced tumor specificity and accumulation compared to monovalent analogues. The few studies that have evaluated APN-specific probes for imaging angiogenesis have focused on cardiac regeneration. These promising results suggest that APN imaging can be expanded to detect and monitor other diseases that are associated with angiogenesis.
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23

A. Liu, Yahu, and Xuebin Liao. "Editorial (Hot Topic: Molecular Imaging Probes)." Current Organic Chemistry 17, no. 6 (April 1, 2013): 563. http://dx.doi.org/10.2174/1385272811317060002.

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24

Ren, Gang, Ying Pan, and Zhen Cheng. "Molecular Probes for Malignant Melanoma Imaging." Current Pharmaceutical Biotechnology 11, no. 6 (September 1, 2010): 590–602. http://dx.doi.org/10.2174/138920110792246465.

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25

Gunosewoyo, Hendra, Mark Coster, and Michael Kassiou. "Molecular Probes for P2X7 Receptor Studies." Current Medicinal Chemistry 14, no. 14 (June 1, 2007): 1505–23. http://dx.doi.org/10.2174/092986707780831023.

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26

Ponyaev, Alexander I., and Jana S. Glukhova. "MOLECULAR ENGINEERING OF MECHANOFLUOROCHROME LUMINESCENT PROBES." Bulletin of the Saint Petersburg State Institute of Technology (Technical University) 59 (2021): 79–85. http://dx.doi.org/10.36807/1998-9849-2021-59-85-79-85.

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Luminescent materials – developed using appropriate molecular engineering – are capable of signaling about various irritants with high sensitivity. In particular, mechanofluorochrome materials show fluorescence emission that is sensitive to mechanical stimulation (pressure, shear, cracking, grinding). Mechanically sensitive compounds are attracting increasing interest and various molecules are synthesized that respond to mechanical stress by changing their fluorescent characteristics (emission wavelength, intensity, polarization, Stokes shift). For a deeper understanding of the relationship between the structure of the dye and its mechanofluorochrome properties, a review of compounds possessing this property is given in the work.
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27

Lee, Seulki, Jin Xie, and Xiaoyuan Chen. "Activatable Molecular Probes for Cancer Imaging." Current Topics in Medicinal Chemistry 10, no. 11 (August 1, 2010): 1135–44. http://dx.doi.org/10.2174/156802610791384270.

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28

Qiao, Ruirui, Ran Zhu, and Mingyuan Gao. "Imaging Tumor Metastases with Molecular Probes." Current Pharmaceutical Design 21, no. 42 (December 7, 2015): 6260–64. http://dx.doi.org/10.2174/1381612821666151027153943.

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29

Liu, Hongguang, Gang Ren, Zheng Miao, Xiaofen Zhang, Xiaodong Tang, Peizhen Han, Sanjiv S. Gambhir, and Zhen Cheng. "Molecular Optical Imaging with Radioactive Probes." PLoS ONE 5, no. 3 (March 1, 2010): e9470. http://dx.doi.org/10.1371/journal.pone.0009470.

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30

Kroemer, R. T. "Molecular modelling probes: docking and scoring." Biochemical Society Transactions 31, no. 5 (October 1, 2003): 980–84. http://dx.doi.org/10.1042/bst0310980.

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A general introduction to molecular modelling techniques in the area of protein–ligand interactions is given. Methods covered range from binding-site analysis to statistical treatment of sets of ligands. The main focus of this paper is on docking and scoring. After an outline of the main concepts, two specific application examples are given.
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31

Harvey, J. F. "Molecular Probes--Technology and Medical Applications." Journal of Medical Genetics 27, no. 6 (June 1, 1990): 407–8. http://dx.doi.org/10.1136/jmg.27.6.407-c.

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32

Zeng, Yun, Jing Zhu, Junqing Wang, Paramanantham Parasuraman, Siddhardha Busi, Surya M. Nauli, Yì Xiáng J. Wáng, Rajasekharreddy Pala, and Gang Liu. "Functional probes for cardiovascular molecular imaging." Quantitative Imaging in Medicine and Surgery 8, no. 8 (September 2018): 838–52. http://dx.doi.org/10.21037/qims.2018.09.19.

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33

Kojima, Hirotatsu, and Tetsuo Nagano. "Cellular imaging by using molecular probes." Folia Pharmacologica Japonica 132, no. 1 (2008): 7–10. http://dx.doi.org/10.1254/fpj.132.7.

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34

Palanisamy, Ramkumar, Ashley R. Connolly, and Matt Trau. "Epiallele Quantification Using Molecular Inversion Probes." Analytical Chemistry 83, no. 7 (April 2011): 2631–37. http://dx.doi.org/10.1021/ac103016n.

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35

Sarder, Pinaki, Dolonchampa Maji, and Samuel Achilefu. "Molecular Probes for Fluorescence Lifetime Imaging." Bioconjugate Chemistry 26, no. 6 (May 22, 2015): 963–74. http://dx.doi.org/10.1021/acs.bioconjchem.5b00167.

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36

Khanolkar, Atmaram D., Sonya L. Palmer, and Alexandros Makriyannis. "Molecular probes for the cannabinoid receptors." Chemistry and Physics of Lipids 108, no. 1-2 (November 2000): 37–52. http://dx.doi.org/10.1016/s0009-3084(00)00186-9.

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37

Van Noorden, Cornelis J. F. "Molecular probes in histochemistry and cytochemistry." Acta Histochemica 100, no. 4 (November 1998): 337. http://dx.doi.org/10.1016/s0065-1281(98)80030-5.

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38

Kevetter, Golda Anne, and Robert B. Leonard. "Molecular probes of the vestibular nerve." Brain Research 928, no. 1-2 (February 2002): 18–29. http://dx.doi.org/10.1016/s0006-8993(01)03264-4.

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39

Leonard, Robert B., and Golda Anne Kevetter. "Molecular probes of the vestibular nerve." Brain Research 928, no. 1-2 (February 2002): 8–17. http://dx.doi.org/10.1016/s0006-8993(01)03268-1.

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40

Ingham, Eileen. "Molecular and antibody probes in diagnosis." Biochemical Education 22, no. 2 (April 1994): 105. http://dx.doi.org/10.1016/0307-4412(94)90104-x.

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41

Albertini, Alberto. "Molecular and antibody probes in diagnosis." Trends in Biotechnology 12, no. 6 (June 1994): 247–48. http://dx.doi.org/10.1016/0167-7799(94)90126-0.

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42

Lin, Xin, Jin Xie, and Xiaoyuan Chen. "Protein-based tumor molecular imaging probes." Amino Acids 41, no. 5 (March 17, 2010): 1013–36. http://dx.doi.org/10.1007/s00726-010-0545-z.

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43

Edlund, Hanna, and Marie Allen. "SNP typing using molecular inversion probes." Forensic Science International: Genetics Supplement Series 1, no. 1 (August 2008): 473–75. http://dx.doi.org/10.1016/j.fsigss.2007.11.014.

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44

Balows, Albert. "Molecular probes: Technology and medical applications." Diagnostic Microbiology and Infectious Disease 12, no. 6 (November 1989): 525. http://dx.doi.org/10.1016/0732-8893(89)90088-6.

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45

COUGHTRIE, MICHAEL, MICHAEL JACKSON, DAVID HARDING, ROBERT CORSER, ROBERT HUME, and BRIAN BURCHELL. "Molecular probes for human UDP-glucuronosyltransferases." Biochemical Society Transactions 16, no. 2 (April 1, 1988): 157–58. http://dx.doi.org/10.1042/bst0160157.

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46

Knowles, Daniel M. "Molecular and antibody probes in diagnosis." Immunology Today 15, no. 10 (October 1994): 500. http://dx.doi.org/10.1016/0167-5699(94)90201-1.

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47

Jacobson, Kenneth A., Dieter Ukena, William Padgett, Kenneth L. Kirk, and John W. Daly. "Molecular probes for extracellular adenosine receptors." Biochemical Pharmacology 36, no. 10 (May 1987): 1697–707. http://dx.doi.org/10.1016/0006-2952(87)90056-6.

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48

HAMER, J. E. "Molecular Probes for Rice Blast Disease." Science 252, no. 5006 (May 3, 1991): 632–33. http://dx.doi.org/10.1126/science.252.5006.632.

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49

Kim, Sun C. "Molecular probes. Technology and medical applications." Gene 81, no. 2 (September 1989): 373. http://dx.doi.org/10.1016/0378-1119(89)90199-6.

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50

Richards, A. M. S., A. Sobolev, A. Baudry, F. Herpin, L. Decin, M. D. Gray, S. Etoka, E. M. L. Humphreys, and W. Vlemmings. "Masers: Precision probes of molecular gas." Advances in Space Research 65, no. 2 (January 2020): 780–89. http://dx.doi.org/10.1016/j.asr.2019.05.052.

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