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Journal articles on the topic 'Molecular glues'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Geiger, Thomas M., Sabine C. Schäfer, Johannes K. Dreizler, Michael Walz, and Felix Hausch. "Clues to molecular glues." Current Research in Chemical Biology 2 (2022): 100018. http://dx.doi.org/10.1016/j.crchbi.2021.100018.

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2

den Besten, Willem, and J. Russell Lipford. "Prospecting for molecular glues." Nature Chemical Biology 16, no. 11 (August 3, 2020): 1157–58. http://dx.doi.org/10.1038/s41589-020-0620-z.

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3

Mogaki, Rina, Kou Okuro, and Takuzo Aida. "Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues." Chemical Science 6, no. 5 (2015): 2802–5. http://dx.doi.org/10.1039/c5sc00524h.

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4

Dayyoub, Tarek, Aleksey Maksimkin, Fedor Senatov, Sergey Kaloshkin, Natalia Anisimova, and Mikhail Kiselevskiy. "A New Approach Based on Glued Multi-Ultra High Molecular Weight Polyethylene Forms to Fabricate Bone Replacement Products." Polymers 12, no. 11 (October 30, 2020): 2545. http://dx.doi.org/10.3390/polym12112545.

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Three types of glue based on thiol-ene reaction, polyvinyl alcohol (PVA)/cellulose, and phenol formaldehyde were prepared and applied on modified ultra-high molecular weight polyethylene (UHMWPE) samples grafted by cellulose. In comparison with unmodified UHMWPE samples, T-peel tests on the modified and grafted UHMWPE films showed an increase in the peel strength values for the glues based on thiol-ene reaction, PVA/cellulose, and phenol formaldehyde by 40, 29, and 41 times, respectively. The maximum peel strength value of 0.62 Kg/cm was obtained for the glue based on phenol formaldehyde. Mechanical tests for the cylindrical multi-UHMWPE forms samples, made of porous UHMWPE as a trabecular layer and an armored layer (cortical layer) that consists of bulk and UHMWPE films, indicated an improvement in the mechanical properties of these samples for all glue types, as a result of the UHMWPE films existence and the increase in the number of their layers. The maximum compressive yield strength and compressive modulus values for the armored layer (bulk and six layers of the UHMWPE films using the glue based on thiol-ene reaction) were 44.1 MPa (an increase of 17%) and 1130 MPa (an increase of 36%), respectively, in comparison with one armored layer of bulk UHMWPE. A hemocompatibility test carried out on these glues clarified that the modified UHMWPE grafted by cellulose with glues based on PVA/cellulose and thiol-ene reaction were classified as biocompatible materials. These multi-UHMWPE forms composites can be considered a promising development for joint reconstruction.

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5

Schreiber, Stuart L. "The Rise of Molecular Glues." Cell 184, no. 1 (January 2021): 3–9. http://dx.doi.org/10.1016/j.cell.2020.12.020.

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6

Gina Vitale. "Molecular glues begin to stick." C&EN Global Enterprise 100, no. 29 (August 22, 2022): 20–24. http://dx.doi.org/10.1021/cen-10029-cover.

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7

Michael McCoy. "Triana launches for molecular glues." C&EN Global Enterprise 100, no. 13 (April 18, 2022): 18. http://dx.doi.org/10.1021/cen-10013-buscon15.

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8

Schreiber, Stuart L. "The Rise of Molecular Glues." Cell 184, no. 1 (January 2021): 3–9. http://dx.doi.org/10.1016/j.cell.2020.12.020.

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9

Rule, Kirrily C., Richard A. Mole, and Dehong Yu. "Which glue to choose? A neutron scattering study of various adhesive materials and their effect on background scattering." Journal of Applied Crystallography 51, no. 6 (November 22, 2018): 1766–72. http://dx.doi.org/10.1107/s1600576718014930.

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The background scattering from numerous frequently used sample adhesives has been investigated to determine the background contribution of these glues when used for inelastic neutron scattering measurements. Starting with a bare Cu sheet, different glues have been trialled, such as GE varnish, CYTOP solution, Teflon tape, Fomblin oil and two-component epoxy glue. Measurements were collected using the PELICAN cold-neutron time-of-flight spectrometer at ANSTO, which is capable of collecting data over a wide range of Q–ω space simultaneously. The results indicate that those glues containing hydrogen give much higher background signals, while those that do not contain hydrogen have a much smaller impact on the background signal. This was observed for both elastic and inelastic neutron scattering.

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10

Rana, Sandeep, Jayapal Reddy Mallareddy, Sarbjit Singh, Lidia Boghean, and Amarnath Natarajan. "Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase." Cancers 13, no. 21 (November 2, 2021): 5506. http://dx.doi.org/10.3390/cancers13215506.

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The cyclin-dependent kinase (CDK) family of proteins play prominent roles in transcription, mRNA processing, and cell cycle regulation, making them attractive cancer targets. Palbociclib was the first FDA-approved CDK inhibitor that non-selectively targets the ATP binding sites of CDK4 and CDK6. In this review, we will briefly inventory CDK inhibitors that are either part of over 30 active clinical trials or recruiting patients. The lack of selectivity among CDKs and dose-limiting toxicities are major challenges associated with the development of CDK inhibitors. Proteolysis Targeting Chimeras (PROTACs) and Molecular Glues have emerged as alternative therapeutic modalities to target proteins. PROTACs and Molecular glues utilize the cellular protein degradation machinery to destroy the target protein. PROTACs are heterobifunctional molecules that form a ternary complex with the target protein and E3-ligase by making two distinct small molecule–protein interactions. On the other hand, Molecular glues function by converting the target protein into a “neo-substrate” for an E3 ligase. Unlike small molecule inhibitors, preclinical studies with CDK targeted PROTACs have exhibited improved CDK selectivity. Moreover, the efficacy of PROTACs and molecular glues are not tied to the dose of these molecular entities but to the formation of the ternary complex. Here, we provide an overview of PROTACs and molecular glues that modulate CDK function as emerging therapeutic modalities.

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11

Gina Vitale. "BMS forms pact for molecular glues." C&EN Global Enterprise 100, no. 30 (August 29, 2022): 12. http://dx.doi.org/10.1021/cen-10030-buscon17.

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12

Jessica Marshall. "Evotec, BMS stick with molecular glues." C&EN Global Enterprise 100, no. 17 (May 16, 2022): 13. http://dx.doi.org/10.1021/cen-10017-buscon16.

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13

Li, Yan, Yi Jia, Xiao-Lin Wang, Hai Shang, and Yu Tian. "Protein-Targeted Degradation Agents Based on Natural Products." Pharmaceuticals 16, no. 1 (December 28, 2022): 46. http://dx.doi.org/10.3390/ph16010046.

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Natural products are an important source of drug lead compounds, and natural products with significant biological activity are constantly being discovered and used in clinical practice. At present, natural products play an important role in the targeted therapy of cancer, cardiovascular and cerebrovascular diseases, nervous system diseases, and autoimmune diseases. Meanwhile, in recent years, the rise of protein-targeted degradation technologies, such as proteolysis-targeting chimeras (PROTACs) and molecular glues, has provided a new solution for drug resistance caused by clinical molecular-targeting drugs. It is noteworthy that natural products and their derivatives, as important components of PROTACs and molecular glues, play an important role in the development of protein-targeting drugs. Hence, this review summarized the protein-targeted degradation agents based on natural products, such as PROTACs and molecular glues. More natural products with the potential to be used in the development of PROTACs and molecular glues as targeted protein degradation agents are still being investigated.

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14

Mirzaei, Yalda, Kerstin Hagemeister, Martina Hüffel, Timo Schwandt, René H. Tolba, and Julia Steitz. "A Novel In Vitro Method to Assess the Microbial Barrier Function of Tissue Adhesives Using Bioluminescence Imaging Technique." BioMed Research International 2022 (January 10, 2022): 1–10. http://dx.doi.org/10.1155/2022/3483238.

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Background. Tissue glues can minimize treatment invasiveness, mitigate the risk of infection, and reduce surgery time; ergo, they have been developed and used in surgical procedures as wound closure devices beside sutures, staples, and metallic grafts. Regardless of their structure or function, tissue glues should show an acceptable microbial barrier function before being used in humans. This study proposes a novel in vitro method using Escherichia coli Lux and bioluminescence imaging technique to assess the microbial barrier function of tissue glues. Different volumes and concentrations of E. coli Lux were applied to precured or cured polyurethane-based tissue glue placed on agar plates. Plates were cultured for 1 h, 24 h, 48 h, and 72 h with bioluminescence signal measurement subsequently. Herein, protocol established a volume of 5 μL of a 1 : 100 dilution of E. coli Lux containing around 2 × 10 7 CFU/mL as optimal for testing polyurethane-based tissue glue. Measurement of OD600nm, determination of CFU/mL, and correlation with the bioluminescence measurement in p/s unit resulted in a good correlation between CFU/mL and p/s and demonstrated good reproducibility of our method. In addition, this in vitro method could show that the tested polyurethane-based tissue glue can provide a reasonable barrier against the microbial penetration and act as a bacterial barrier for up to 48 h with no penetration and up to 72 h with a low level of penetration through the material. Overall, we have established a novel, sensitive, and reproducible in vitro method using the bioluminescence imaging technique for testing the microbial barrier function of new tissue glues.

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15

Soini, Lorenzo, Seppe Leysen, Jeremy Davis, and Christian Ottmann. "Molecular glues to stabilise protein–protein interactions." Current Opinion in Chemical Biology 69 (August 2022): 102169. http://dx.doi.org/10.1016/j.cbpa.2022.102169.

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16

Che, Ye, Adam M. Gilbert, Veerabahu Shanmugasundaram, and Mark C. Noe. "Inducing protein-protein interactions with molecular glues." Bioorganic & Medicinal Chemistry Letters 28, no. 15 (August 2018): 2585–92. http://dx.doi.org/10.1016/j.bmcl.2018.04.046.

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17

Mogaki, Rina, P. K. Hashim, Kou Okuro, and Takuzo Aida. "Guanidinium-based “molecular glues” for modulation of biomolecular functions." Chem. Soc. Rev. 46, no. 21 (2017): 6480–91. http://dx.doi.org/10.1039/c7cs00647k.

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18

Ye, Ya Nan, Kunpeng Cui, Wei Hong, Xueyu Li, Chengtao Yu, Dominique Hourdet, Tasuku Nakajima, Takayuki Kurokawa, and Jian Ping Gong. "Molecular mechanism of abnormally large nonsoftening deformation in a tough hydrogel." Proceedings of the National Academy of Sciences 118, no. 14 (March 29, 2021): e2014694118. http://dx.doi.org/10.1073/pnas.2014694118.

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Tough soft materials usually show strain softening and inelastic deformation. Here, we study the molecular mechanism of abnormally large nonsoftening, quasi-linear but inelastic deformation in tough hydrogels made of hyperconnective physical network and linear polymers as molecular glues to the network. The interplay of hyperconnectivity of network and effective load transfer by molecular glues prevents stress concentration, which is revealed by an affine deformation of the network to the bulk deformation up to sample failure. The suppression of local stress concentration and strain amplification plays a key role in avoiding necking or strain softening and endows the gels with a unique large nonsoftening, quasi-linear but inelastic deformation.

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19

Rittschof, Daniel, Tara Essock-Burns, Gary Dickinson, S. Zmina, and N. Alberman. "Natural glues and fouling management by interfering with glue curing." Journal of Agricultural and Marine Sciences [JAMS] 20 (January 1, 2015): 34. http://dx.doi.org/10.24200/jams.vol20iss0pp34-39.

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Multidisciplinary approaches and modern technology provide insights to glue curing that are stimulatingand controversial. Our team applies classic and modern theory and techniques to the study of barnacle glue. Techniques include physical measures, bacteriology, behavior, physiology, biochemistry, microscopy, spectroscopy, tomography, tandem mass spectrometry, molecular biology and proteomics. Theory is grounded in evolution and previous literature. Here, we use data from these techniques to support the hypothesis that barnacle glue curing is similar toblood clotting and propose a model for how glue cures. Similar to blood clotting, barnacle glue curing involves enzymatic activation of precursors and rearrangement of structural molecules to form a crosslinked material. Barnacle larval settlement, bacteriology and biochemical data show glue contains large amounts of small peptides. Their role in glue curing has been overlooked. The peptides comprise 15 to 30% of partially cured glue. Because they have little secondary structure, the peptides can associate with binding domains on the substrate and interface with the larger, well-described structural proteins known in barnacle glue. Enzymes participate in curing of barnacle glue. Siloxanes impact glue-curing enzymes. They potentiate trypsin activity and inhibit transglutaminase activity. Changing enzymeactivity impacts how glue cures. Disrupting the curing process of biological glues is central to effective cleaning strategies for fouling management. Thus silicones that interfere with enzyme activity have potential as additives in easy cleansurfaces. The environmental impacts of organosilicones that are generated by biological processes need to be addressed

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20

Gillingham, Dennis. "Fantastic Molecular Glues and Where to Find them." CHIMIA International Journal for Chemistry 75, no. 5 (May 28, 2021): 439–41. http://dx.doi.org/10.2533/chimia.2021.439.

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21

Tsukruk, V. V. "Molecular Lubricants and Glues for Micro- and Nanodevices." Advanced Materials 13, no. 2 (January 2001): 95–108. http://dx.doi.org/10.1002/1521-4095(200101)13:2<95::aid-adma95>3.0.co;2-j.

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22

Zolkiewski, Sławomir. "Testing of Fibreglass-Metal Laminates in Epoxy Warp Connected by Means of the Adhesive Layer." Solid State Phenomena 199 (March 2013): 599–604. http://dx.doi.org/10.4028/www.scientific.net/ssp.199.599.

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The fibre-metal laminate specimens were connected with steel plates by means of the glue joints. The influence of the type of connection on composite mechanical properties (displacement vs. force characteristics) was analyzed. The glue joint between the laminate and the steel plate guarantees even distribution of the displacement during tests. The method of connecting laminates by means of glue joints leads to the connection with the smallest overall dimensions and weight. In the initial research the samples connected by means of different glues were tested.

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23

GRIFFIN, Martin, Rita CASADIO, and Carlo M. BERGAMINI. "Transglutaminases: Nature’s biological glues." Biochemical Journal 368, no. 2 (December 1, 2002): 377–96. http://dx.doi.org/10.1042/bj20021234.

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Transglutaminases (Tgases) are a widely distributed group of enzymes that catalyse the post-translational modification of proteins by the formation of isopeptide bonds. This occurs either through protein cross-linking via ∊-(γ-glutamyl)lysine bonds or through incorporation of primary amines at selected peptide-bound glutamine residues. The cross-linked products, often of high molecular mass, are highly resistant to mechanical challenge and proteolytic degradation, and their accumulation is found in a number of tissues and processes where such properties are important, including skin, hair, blood clotting and wound healing. However, deregulation of enzyme activity generally associated with major disruptions in cellular homoeostatic mechanisms has resulted in these enzymes contributing to a number of human diseases, including chronic neurodegeneration, neoplastic diseases, autoimmune diseases, diseases involving progressive tissue fibrosis and diseases related to the epidermis of the skin. In the present review we detail the structural and regulatory features important in mammalian Tgases, with particular focus on the ubiquitous type 2 tissue enzyme. Physiological roles and substrates are discussed with a view to increasing and understanding the pathogenesis of the diseases associated with transglutaminases. Moreover the ability of these enzymes to modify proteins and act as biological glues has not gone unnoticed by the commercial sector. As a consequence, we have included some of the present and future biotechnological applications of this increasingly important group of enzymes.

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24

Arnarez, C., S. J. Marrink, and X. Periole. "Molecular mechanism of cardiolipin-mediated assembly of respiratory chain supercomplexes." Chemical Science 7, no. 7 (2016): 4435–43. http://dx.doi.org/10.1039/c5sc04664e.

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We reveal the molecular mechanism by which cardiolipin glues respiratory complexes into supercomplexes. This mechanism defines a new biophysico-chemical pathway of protein–lipid interplay, with broad general implications for the dynamic organization of crowded cell membranes.

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25

Ren, Changyu, Xiaohong Gan, Houfeng Zhou, Jinqi Li, and Jifa Zhang. "Molecular glues targeting protein degradation pathways for drug discovery." Future Medicinal Chemistry 14, no. 3 (January 2022): 135–37. http://dx.doi.org/10.4155/fmc-2021-0229.

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26

Swarup, Vimal P., Caitlin P. Mencio, Vladimir Hlady, and Balagurunathan Kuberan. "Sugar glues for broken neurons." BioMolecular Concepts 4, no. 3 (June 1, 2013): 233–57. http://dx.doi.org/10.1515/bmc-2012-0042.

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AbstractProteoglycans (PGs) regulate diverse functions in the central nervous system (CNS) by interacting with a number of growth factors, matrix proteins, and cell surface molecules. Heparan sulfate (HS) and chondroitin sulfate (CS) are two major glycosaminoglycans present in the PGs of the CNS. The functionality of these PGs is to a large extent dictated by the fine sulfation patterns present on their glycosaminoglycan (GAG) chains. In the past 15 years, there has been a significant expansion in our knowledge on the role of HS and CS chains in various neurological processes, such as neuronal growth, regeneration, plasticity, and pathfinding. However, defining the relation between distinct sulfation patterns of the GAGs and their functionality has thus far been difficult. With the emergence of novel tools for the synthesis of defined GAG structures, and techniques for their characterization, we are now in a better position to explore the structure-function relation of GAGs in the context of their sulfation patterns. In this review, we discuss the importance of GAGs on CNS development, injury, and disorders with an emphasis on their sulfation patterns. Finally, we outline several GAG-based therapeutic strategies to exploit GAG chains for ameliorating various CNS disorders.

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27

Guhan, Samantha, Si-Liang Peng, Hrag Janbatian, Stephanie Saadeh, Stephen Greenstein, Faisal Al Bahrani, Ali Fadlallah, Tsai-Chu Yeh, and Samir A. Melki. "Surgical adhesives in ophthalmology: history and current trends." British Journal of Ophthalmology 102, no. 10 (March 26, 2018): 1328–35. http://dx.doi.org/10.1136/bjophthalmol-2017-311643.

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Tissue adhesives are gaining popularity in ophthalmology, as they could potentially reduce the complications associated with current surgical methods. An ideal tissue adhesive should have superior tensile strength, be non-toxic and anti-inflammatory, improve efficiency and be cost-effective. Both synthetic and biological glues are available. The primary synthetic glues include cyanoacrylate and the recently introduced polyethylene glycol (PEG) derivatives, while most biological glues are composed of fibrin. Cyanoacrylate has a high tensile strength, but rapidly polymerises upon contact with any fluid and has been associated with histotoxicity. Fibrin induces less toxic and inflammatory reactions, and its polymerisation time can be controlled. Tensile strength studies have shown that fibrin is not as strong as cyanoacrylate. While more research is needed, PEG variants currently appear to have the most promise. These glues are non-toxic, strong and time-effective. Through MEDLINE and internet searches, this paper presents a systematic review of the current applications of surgical adhesives to corneal, glaucoma, retinal, cataract and strabismus surgeries. Our review suggests that surgical adhesives have promise to reduce problems in current ophthalmic surgical procedures.

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28

Wang, Fang, Hongliang Wang, and Tao Li. "Seaming the interfaces between topologically distinct metal–organic frameworks using random copolymer glues." Nanoscale 11, no. 5 (2019): 2121–25. http://dx.doi.org/10.1039/c8nr09777a.

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29

Luzinov, Igor, Daungrut Julthongpiput, Andrea Liebmann-Vinson, Tricia Cregger, Mark D. Foster, and Vladimir V. Tsukruk. "Epoxy-Terminated Self-Assembled Monolayers: Molecular Glues for Polymer Layers." Langmuir 16, no. 2 (January 2000): 504–16. http://dx.doi.org/10.1021/la990500+.

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30

Isobe, Yosuke, Mikiko Okumura, Lynn M. McGregor, Scott M. Brittain, Michael D. Jones, Xiaoyou Liang, Ross White, et al. "Manumycin polyketides act as molecular glues between UBR7 and P53." Nature Chemical Biology 16, no. 11 (June 22, 2020): 1189–98. http://dx.doi.org/10.1038/s41589-020-0557-2.

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31

Dong, Guoqiang, Yu Ding, Shipeng He, and Chunquan Sheng. "Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery." Journal of Medicinal Chemistry 64, no. 15 (July 28, 2021): 10606–20. http://dx.doi.org/10.1021/acs.jmedchem.1c00895.

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32

Zeltz, Cédric, Joseph Orgel, and Donald Gullberg. "Molecular composition and function of integrin-based collagen glues—Introducing COLINBRIs." Biochimica et Biophysica Acta (BBA) - General Subjects 1840, no. 8 (August 2014): 2533–48. http://dx.doi.org/10.1016/j.bbagen.2013.12.022.

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33

Lo, Momath, Rémi Pires, Karim Diaw, Diariatou Gningue-Sall, Mehmet A. Oturan, Jean-Jacques Aaron, and Mohamed M. Chehimi. "Diazonium Salts: Versatile Molecular Glues for Sticking Conductive Polymers to Flexible Electrodes." Surfaces 1, no. 1 (August 8, 2018): 43–58. http://dx.doi.org/10.3390/surfaces1010005.

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Adhesion of polymers to surfaces is of the upmost importance in timely applications such as protective coatings, biomaterials, sensors, new power sources and soft electronics. In this context, this work examines the role of molecular interactions in the adhesion of polypyrrole thin films to flexible Indium Tin Oxide (ITO) electrodes grafted with aryl layers from various diazonium salts, namely 4-carboxybenzenediazonium (ITO-CO2H), 4-sulfonicbenzenediazonium (ITO-SO3H), 4-N,N-dimethylbenzenediazonium (ITO-N(CH3)2), 4-aminobenzenediazonium (ITO-NH2), 4-cyanobenzenediazonium (ITO-CN) and 4-N-phenylbenzenediazonium (ITO-NHPh). It was demonstrated that PPy thin layers were adherent to all aryl-modified surfaces, whereas adhesive failure was noted for bare ITO following simple solvent washing or sonication. Adhesion of polypyrrole was investigated in terms of hydrophilic/hydrophobic character of the underlying aryl layer as probed by contact angle measurements. It was found that sulfonic acid-doped polypyrrole (PPy-BSA) thin films were preferably deposited on the most hydrophobic surfaces. More importantly, the redox properties and electrochemical impedance of PPy were closely related to the hydrophobic character of the aryl layers. This work demonstrates that diazonium compounds are unique molecular glues for conductive polymers and permit to tune their interfacial properties. With robust, diazonium-based architectured interfaces, one can design high performance materials for e.g., sensors, printed soft electronics and flexible thermoelectrics.

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34

Okuro, Kou, Mizuki Sasaki, and Takuzo Aida. "Boronic Acid-Appended Molecular Glues for ATP-Responsive Activity Modulation of Enzymes." Journal of the American Chemical Society 138, no. 17 (April 19, 2016): 5527–30. http://dx.doi.org/10.1021/jacs.6b02664.

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35

Hentzen, Nina B., Rina Mogaki, Saya Otake, Kou Okuro, and Takuzo Aida. "Intracellular Photoactivation of Caspase-3 by Molecular Glues for Spatiotemporal Apoptosis Induction." Journal of the American Chemical Society 142, no. 18 (April 10, 2020): 8080–84. http://dx.doi.org/10.1021/jacs.0c01823.

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36

Kuetting, Daniel, Patrick Kupczyk, Tatjana Dell, Julian A. Luetkens, Carsten Meyer, Ulrike I. Attenberger, and Claus C. Pieper. "In Vitro Evaluation of Acrylic Adhesives in Lymphatic Fluids-Influence of Glue Type and Procedural Parameters." Biomedicines 10, no. 5 (May 21, 2022): 1195. http://dx.doi.org/10.3390/biomedicines10051195.

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To evaluate the embolic properties of different acrylic adhesive/iodized oil mixtures for lymphatic interventions. Polymerization of histoacryl (HA) (Bayer Healthcare) and glubran 2 (GL) (GEM) mixed with iodized oil (ratios 1:0–1:7) were investigated in lymphatic fluids with low and high triglyceride (low TG & high TG) contents. Static polymerization time and dynamic polymerization experiments with different volumes of glucose flush (1, 2 and 5 mL) were performed to simulate thoracic duct embolization. For both glues, static polymerization times were longer when the iodized oil content was increased and when performed in high TG lymphatic fluid. In the dynamic experiments, the prolongation of polymerization due to the oil content and TG levels was less pronounced for both glue types. Increased lymphatic flow rates decreased embolization times for low glue/oil ratios while preventing embolization for high glue/oil ratios. Higher glucose flush volumes increased occlusion times. Polymerization times of acrylic glue in a lymphatic fluid are prolonged by increasing the iodized oil concentration and triglyceride concentration as well as by using larger volumes of glucose flush. Increased lymphatic flow rates decrease embolization times for low glue/oil ratios and may prevent embolization for high glue/oil ratios.

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37

Hou, Changshun, Yung-Fu Chang, and Xi Yao. "Supramolecular Adhesive Materials with Antimicrobial Activity for Emerging Biomedical Applications." Pharmaceutics 14, no. 8 (August 2, 2022): 1616. http://dx.doi.org/10.3390/pharmaceutics14081616.

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Traditional adhesives or glues such as cyanoacrylates, fibrin glue, polyethylene glycol, and their derivatives have been widely used in biomedical fields. However, they still suffer from numerous limitations, including the mechanical mismatch with biological tissues, weak adhesion on wet surfaces, biological incompatibility, and incapability of integrating desired multifunction. In addition to adaptive mechanical and adhesion properties, adhesive biomaterials should be able to integrate multiple functions such as stimuli-responsiveness, control-releasing of small or macromolecular therapeutic molecules, hosting of various cells, and programmable degradation to fulfill the requirements in the specific biological systems. Therefore, rational molecular engineering and structural designs are required to facilitate the development of functional adhesive materials. This review summarizes and analyzes the current supramolecular design strategies of representative adhesive materials, serving as a general guide for researchers seeking to develop novel adhesive materials for biomedical applications.

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38

Wojnacki, José, and Thierry Galli. "A new actin-binding domain glues autophagy together." Journal of Biological Chemistry 293, no. 12 (March 23, 2018): 4575–76. http://dx.doi.org/10.1074/jbc.h118.002041.

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39

Damiano, Giuseppe, Vincenzo Davide Palumbo, Salvatore Fazzotta, Francesco Curione, Giulia Lo Monte, Valerio Maria Bartolo Brucato, and Attilio Ignazio Lo Monte. "Current Strategies for Tracheal Replacement: A Review." Life 11, no. 7 (June 25, 2021): 618. http://dx.doi.org/10.3390/life11070618.

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Airway cancers have been increasing in recent years. Tracheal resection is commonly performed during surgery and is burdened from post-operative complications severely affecting quality of life. Tracheal resection is usually carried out in primary tracheal tumors or other neoplasms of the neck region. Regenerative medicine for tracheal replacement using bio-prosthesis is under current research. In recent years, attempts were made to replace and transplant human cadaver trachea. An effective vascular supply is fundamental for a successful tracheal transplantation. The use of biological scaffolds derived from decellularized tissues has the advantage of a three-dimensional structure based on the native extracellular matrix promoting the perfusion, vascularization, and differentiation of the seeded cell typologies. By appropriately modulating some experimental parameters, it is possible to change the characteristics of the surface. The obtained membranes could theoretically be affixed to a decellularized tissue, but, in practice, it needs to ensure adhesion to the biological substrate and/or glue adhesion with biocompatible glues. It is also known that many of the biocompatible glues can be toxic or poorly tolerated and induce inflammatory phenomena or rejection. In tissue and organ transplants, decellularized tissues must not produce adverse immunological reactions and lead to rejection phenomena; at the same time, the transplant tissue must retain the mechanical properties of the original tissue. This review describes the attempts so far developed and the current lines of research in the field of tracheal replacement.

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Li, Fengzhi, Ieman A. M. Aljahdali, and Xiang Ling. "Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein–Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases." International Journal of Molecular Sciences 23, no. 11 (June 1, 2022): 6206. http://dx.doi.org/10.3390/ijms23116206.

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Molecular glue (MG) compounds are a type of unique small molecule that can change the protein–protein interactions (PPIs) and interactomes by degrading, stabilizing, or activating the target protein after their binging. These small-molecule MGs are gradually being recognized for their potential application in treating human diseases, including cancer. Evidence suggests that small-molecule MG compounds could essentially target any proteins, which play critical roles in human disease etiology, where many of these protein targets were previously considered undruggable. Intriguingly, most MG compounds with high efficacy for cancer treatment can glue on and control multiple key protein targets. On the other hand, a single key protein target can also be glued by multiple MG compounds with distinct chemical structures. The high flexibility of MG–protein interaction profiles provides rich soil for the growth and development of small-molecule MG compounds that can be used as molecular tools to assist in unraveling disease mechanisms, and they can also facilitate drug development for the treatment of human disease, especially human cancer. In this review, we elucidate this concept by using various types of small-molecule MG compounds and their corresponding protein targets that have been documented in the literature.

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Romei, Matthew G., and Steven G. Boxer. "Split Green Fluorescent Proteins: Scope, Limitations, and Outlook." Annual Review of Biophysics 48, no. 1 (May 6, 2019): 19–44. http://dx.doi.org/10.1146/annurev-biophys-051013-022846.

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Many proteins can be split into fragments that spontaneously reassemble, without covalent linkage, into a functional protein. For split green fluorescent proteins (GFPs), fragment reassembly leads to a fluorescent readout, which has been widely used to investigate protein–protein interactions. We review the scope and limitations of this approach as well as other diverse applications of split GFPs as versatile sensors, molecular glues, optogenetic tools, and platforms for photophysical studies.

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Lukashenko, T. A., A. N. Zubik, A. L. Bulyanitsa, and G. E. Rudnitskaya. "Domestic photo-cured acrylate glues for adhesive bonding microfluidic chips from polymethylmethacrylate." Plasticheskie massy, no. 11-12 (January 17, 2023): 47–50. http://dx.doi.org/10.35164/0554-2901-2022-11-12-47-50.

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It is shown that the adhesive bonding of microfluidic chips made of polymethylmethacrylate, bonded with domestic glues SM Chemie 301 and SM Chemie 700, withstand pressure up to 0.3 MPa (1 hour), as well as dynamic loads arising from repeated temperature changes from 60 to 95°C. These adhesives do not inhibit the polymerase chain reaction and can be recommended for bonding microfluidic chips for this method of molecular diagnostics.

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Arisaka, Akio, Rina Mogaki, Kou Okuro, and Takuzo Aida. "Caged Molecular Glues as Photoactivatable Tags for Nuclear Translocation of Guests in Living Cells." Journal of the American Chemical Society 140, no. 7 (February 12, 2018): 2687–92. http://dx.doi.org/10.1021/jacs.7b13614.

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Wachter, Rebekka M. "A peptide adhesive molded by magnesium glues Rubisco's subunits together." Journal of Biological Chemistry 292, no. 16 (April 21, 2017): 6851–52. http://dx.doi.org/10.1074/jbc.h116.767145.

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Guillen, Kévin, Pierre-Olivier Comby, Anne-Virginie Salsac, Nicolas Falvo, Marc Lenfant, Alexandra Oudot, Hugo Sikner, et al. "X-ray Microtomography to Assess Determinants of In Vivo N-Butyl Cyanoacrylate Glubran®2 Polymerization: A Rabbit-Model Study." Biomedicines 10, no. 10 (October 19, 2022): 2625. http://dx.doi.org/10.3390/biomedicines10102625.

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Although introduced decades ago, few cyanoacrylate glues have been approved for endovascular use, despite evidence of their usefulness, notably for complex procedures suchas hemostatic embolization. Indications include massive bleeding requiring emergent hemostasis and prevention of severe bleeding during scheduled surgery to remove a hypervascular tumor. Adding radiopaque Lipiodol Ultra Fluid® (LUF) modulates glue polymerization and allows fluoroscopic guidance, but few comparative in vivo studies have assessed the impact of the resulting change in glue concentration or of other factors such as target-vessel blood flow. In a rabbit model, we used ex vivo X-ray microtomography to assess the results of in vivo renal-artery embolization by various mixtures of N-butyl cyanoacrylate (NBCA), metacryloxysulfolane, and LUF. Overall, penetration to the superficial interlobular arteries was achieved in about two-thirds of cases and into the capillaries in nearly half the cases, while cast fragmentation was seen in slightly more than half the cases. Greater NBCA dilution and the blocked-blood-flow technique were independently associated with greater distality of penetration. Blocked-blood-flow injection was independently associated with absence of fragmentation, capillary penetration, a shorter cast-to-capsule distance, and higher cast attenuation. A larger mixture volume was independently associated with higher indexed cast ratio and deeper penetration. Finally, microtomography is an adapted tool to assess ex vivo distribution of glue cast.

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Zhao, Yiming, Nong Zhang, Guangyao Si, and Xuehua Li. "Study on the Optimal Groove Shape and Glue Material for Fiber Bragg Grating Measuring Bolts." Sensors 18, no. 6 (June 2, 2018): 1799. http://dx.doi.org/10.3390/s18061799.

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Fiber Bragg grating (FBG) measuring bolts, as a useful tool to evaluate the behaviors of steel bolts in underground engineering, can be manufactured by gluing the FBG sensors inside the grooves, which are usually symmetrical cuts along the steel bolt rod. The selection of the cut shape and the glue types could perceivably affect the final supporting strength of the bolts. Unfortunately, the impact of cut shape and glue type on bolting strength is not yet clear. In this study, based on direct tension tests, full tensile load–displacement curves of rock bolts with different groove shapes were obtained and analyzed. The effects of groove shape on the bolt strength were discussed, and the stress redistribution in the cross-section of a rock bolt with different grooves was simulated using ANSYS. The results indicated that the trapezoidal groove is best for manufacturing the FBG bolt due to its low reduction of supporting strength. Four types of glues commonly used for the FBG sensors were assessed by conducting tensile tests on the mechanical testing and simulation system and the static and dynamic optical interrogators system. Using linear regression analysis, the relationship between the reflected wavelength of FBG sensors and tensile load was obtained. Practical recommendations for glue selection in engineering practice are also provided.

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Jain, Ritu, and Sarika Wairkar. "Recent developments and clinical applications of surgical glues: An overview." International Journal of Biological Macromolecules 137 (September 2019): 95–106. http://dx.doi.org/10.1016/j.ijbiomac.2019.06.208.

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Chernobrovkin, Alexey L., Cindy Cázares-Körner, Tomas Friman, Isabel Martin Caballero, Daniele Amadio, and Daniel Martinez Molina. "A Tale of Two Tails: Efficient Profiling of Protein Degraders by Specific Functional and Target Engagement Readouts." SLAS DISCOVERY: Advancing the Science of Drug Discovery 26, no. 4 (January 15, 2021): 534–46. http://dx.doi.org/10.1177/2472555220984372.

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Targeted protein degradation represents an area of great interest, potentially offering improvements with respect to dosing, side effects, drug resistance, and reaching “undruggable” proteins compared with traditional small-molecule therapeutics. A major challenge in the design and characterization of degraders acting as molecular glues is that binding of the molecule to the protein of interest (PoI) is not needed for efficient and selective protein degradation; instead, one needs to understand the interaction with the responsible ligase. Similarly, for proteasome targeting chimeras (PROTACs), understanding the binding characteristics of the PoI alone is not sufficient. Therefore, simultaneously assessing the binding to both PoI and the E3 ligase as well as the resulting degradation profile is of great value. The cellular thermal shift assay (CETSA) is an unbiased cell-based method, designed to investigate the interaction of compounds with their cellular protein targets by measuring compound-induced changes in protein thermal stability. In combination with mass spectrometry (MS), CETSA can simultaneously evaluate compound-induced changes in the stability of thousands of proteins. We have used CETSA MS to profile a number of protein degraders, including molecular glues (e.g., immunomodulatory drugs) and PROTACs, to understand mode of action and to deconvolute off-target effects in intact cells. Within the same experiment, we were able to monitor both target engagement by observing changes in protein thermal stability as well as efficacy by simultaneous assessment of protein abundances. This allowed us to correlate target engagement (i.e., binding to the PoI and ligases) and functional readout (i.e., degrader induced protein degradation).

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Chen, He, Jing Liu, H. Ümit Kaniskan, Wenyi Wei, and Jian Jin. "Folate-Guided Protein Degradation by Immunomodulatory Imide Drug-Based Molecular Glues and Proteolysis Targeting Chimeras." Journal of Medicinal Chemistry 64, no. 16 (August 11, 2021): 12273–85. http://dx.doi.org/10.1021/acs.jmedchem.1c00901.

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Waite, J. Herbert. "The phylogeny and chemical diversity of quinone-tanned glues and varnishes." Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 97, no. 1 (January 1990): 19–29. http://dx.doi.org/10.1016/0305-0491(90)90172-p.

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