Academic literature on the topic 'Molecular glues'

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Journal articles on the topic "Molecular glues"

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Geiger, Thomas M., Sabine C. Schäfer, Johannes K. Dreizler, Michael Walz, and Felix Hausch. "Clues to molecular glues." Current Research in Chemical Biology 2 (2022): 100018. http://dx.doi.org/10.1016/j.crchbi.2021.100018.

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den Besten, Willem, and J. Russell Lipford. "Prospecting for molecular glues." Nature Chemical Biology 16, no. 11 (August 3, 2020): 1157–58. http://dx.doi.org/10.1038/s41589-020-0620-z.

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Mogaki, Rina, Kou Okuro, and Takuzo Aida. "Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues." Chemical Science 6, no. 5 (2015): 2802–5. http://dx.doi.org/10.1039/c5sc00524h.

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Dayyoub, Tarek, Aleksey Maksimkin, Fedor Senatov, Sergey Kaloshkin, Natalia Anisimova, and Mikhail Kiselevskiy. "A New Approach Based on Glued Multi-Ultra High Molecular Weight Polyethylene Forms to Fabricate Bone Replacement Products." Polymers 12, no. 11 (October 30, 2020): 2545. http://dx.doi.org/10.3390/polym12112545.

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Three types of glue based on thiol-ene reaction, polyvinyl alcohol (PVA)/cellulose, and phenol formaldehyde were prepared and applied on modified ultra-high molecular weight polyethylene (UHMWPE) samples grafted by cellulose. In comparison with unmodified UHMWPE samples, T-peel tests on the modified and grafted UHMWPE films showed an increase in the peel strength values for the glues based on thiol-ene reaction, PVA/cellulose, and phenol formaldehyde by 40, 29, and 41 times, respectively. The maximum peel strength value of 0.62 Kg/cm was obtained for the glue based on phenol formaldehyde. Mechanical tests for the cylindrical multi-UHMWPE forms samples, made of porous UHMWPE as a trabecular layer and an armored layer (cortical layer) that consists of bulk and UHMWPE films, indicated an improvement in the mechanical properties of these samples for all glue types, as a result of the UHMWPE films existence and the increase in the number of their layers. The maximum compressive yield strength and compressive modulus values for the armored layer (bulk and six layers of the UHMWPE films using the glue based on thiol-ene reaction) were 44.1 MPa (an increase of 17%) and 1130 MPa (an increase of 36%), respectively, in comparison with one armored layer of bulk UHMWPE. A hemocompatibility test carried out on these glues clarified that the modified UHMWPE grafted by cellulose with glues based on PVA/cellulose and thiol-ene reaction were classified as biocompatible materials. These multi-UHMWPE forms composites can be considered a promising development for joint reconstruction.
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Schreiber, Stuart L. "The Rise of Molecular Glues." Cell 184, no. 1 (January 2021): 3–9. http://dx.doi.org/10.1016/j.cell.2020.12.020.

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Gina Vitale. "Molecular glues begin to stick." C&EN Global Enterprise 100, no. 29 (August 22, 2022): 20–24. http://dx.doi.org/10.1021/cen-10029-cover.

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Michael McCoy. "Triana launches for molecular glues." C&EN Global Enterprise 100, no. 13 (April 18, 2022): 18. http://dx.doi.org/10.1021/cen-10013-buscon15.

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Schreiber, Stuart L. "The Rise of Molecular Glues." Cell 184, no. 1 (January 2021): 3–9. http://dx.doi.org/10.1016/j.cell.2020.12.020.

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Rule, Kirrily C., Richard A. Mole, and Dehong Yu. "Which glue to choose? A neutron scattering study of various adhesive materials and their effect on background scattering." Journal of Applied Crystallography 51, no. 6 (November 22, 2018): 1766–72. http://dx.doi.org/10.1107/s1600576718014930.

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The background scattering from numerous frequently used sample adhesives has been investigated to determine the background contribution of these glues when used for inelastic neutron scattering measurements. Starting with a bare Cu sheet, different glues have been trialled, such as GE varnish, CYTOP solution, Teflon tape, Fomblin oil and two-component epoxy glue. Measurements were collected using the PELICAN cold-neutron time-of-flight spectrometer at ANSTO, which is capable of collecting data over a wide range of Q–ω space simultaneously. The results indicate that those glues containing hydrogen give much higher background signals, while those that do not contain hydrogen have a much smaller impact on the background signal. This was observed for both elastic and inelastic neutron scattering.
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Rana, Sandeep, Jayapal Reddy Mallareddy, Sarbjit Singh, Lidia Boghean, and Amarnath Natarajan. "Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase." Cancers 13, no. 21 (November 2, 2021): 5506. http://dx.doi.org/10.3390/cancers13215506.

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The cyclin-dependent kinase (CDK) family of proteins play prominent roles in transcription, mRNA processing, and cell cycle regulation, making them attractive cancer targets. Palbociclib was the first FDA-approved CDK inhibitor that non-selectively targets the ATP binding sites of CDK4 and CDK6. In this review, we will briefly inventory CDK inhibitors that are either part of over 30 active clinical trials or recruiting patients. The lack of selectivity among CDKs and dose-limiting toxicities are major challenges associated with the development of CDK inhibitors. Proteolysis Targeting Chimeras (PROTACs) and Molecular Glues have emerged as alternative therapeutic modalities to target proteins. PROTACs and Molecular glues utilize the cellular protein degradation machinery to destroy the target protein. PROTACs are heterobifunctional molecules that form a ternary complex with the target protein and E3-ligase by making two distinct small molecule–protein interactions. On the other hand, Molecular glues function by converting the target protein into a “neo-substrate” for an E3 ligase. Unlike small molecule inhibitors, preclinical studies with CDK targeted PROTACs have exhibited improved CDK selectivity. Moreover, the efficacy of PROTACs and molecular glues are not tied to the dose of these molecular entities but to the formation of the ternary complex. Here, we provide an overview of PROTACs and molecular glues that modulate CDK function as emerging therapeutic modalities.
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Dissertations / Theses on the topic "Molecular glues"

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Haghighi, Zahra. "Molecular characterization of animal glues for the purpose of restoration treatments." Master's thesis, Universidade de Évora, 2019. http://hdl.handle.net/10174/27680.

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Abstract: Several thousand years ago, mankind perceived the gap and the need for an adhesive in order to make complicated objects consisting of two or more different or even same materials. Among all the materials that have been used throughout history, animal glue has been employed as an adhesive for several various tasks and still has kept its application. Animal glue has been used in book binding, painting binders, furniture manufacturing, to name but a few. Today, in cultural heritage field, it is being used as adhesive in restoration treatments. It is of great importance for conservators to be confident in their knowledge of the original materials they are using and introducing to the ‘matrix’ of cultural heritage objects in order to make proper decision in the process of restoration. Animal glues, however, are intrinsically challenging materials due to the fact that different animals’ collagen proteins exhibit different behaviors or performances due to their different origin or preparation processes. Accordingly, different animal glues are used for different tasks. Therefore, it is critical for conservators to know the composing materials of animal glues they employ. In this thesis, collagen proteins of several samples of animal glue which have been provided by restoration laboratories of both S. Orsola Benincasa, Naples, Italy and Museo del Prado, Madrid, Spain were identified by MALDI-TOF and LC-MS/MS coupled with Mascot bioinformatic tool with the goal of protein identification. Samples of S. Orsola Benincasa were analyzed by LC-MS/MS and Mascot in order to identify the specie(s) and tissue(s) they have been made of. Out of 8 samples, only one of them was made of what the label claimed to be. These results showed the importance of these experiments for the art conservation community as using known and standard materials forms a great part of their actions toward restoration of cultural heritage objects. Additionally, one of the samples, rabbit glue totten sixties, were chosen to demonstrate, in a preliminary manner, the capabilities of proteomics in the evaluation of degradation phenomenon. Samples of Museo del Prado were analyzed by MALDI-TOF in order to demonstrate differences between the amount of information one can gain from MALDITOF in comparison with LC-MS/MS. Finally, one of the samples of Museo del Prado was used to improve the sample preparation protocol, by examining the hypothesis of whether or not combining two protocols could yield higher sequence coverage and betterquality spectra. Results of the series of experiments showed that adding ZipTip clean-up step after StageTip protocol increases the number of peptides in respect to what can be obtained by using a single chromatographic step.
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Hakariya, Hayase. "Non-Genetic Cell-Surface Modification with a Self-Assembling Molecular Glue." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263577.

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付記する学位プログラム名: 充実した健康長寿社会を築く総合医療開発リーダー育成プログラム
京都大学
新制・課程博士
博士(医科学)
甲第23116号
医科博第127号
京都大学大学院医学研究科医科学専攻
(主査)教授 藤田 恭之, 教授 渡邊 直樹, 教授 岩田 想
学位規則第4条第1項該当
Doctor of Medical Science
Kyoto University
DFAM
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Sireesha, Dommaraju. "An Investigation of the Nano-Organization of Glucose Transporters, Glut1 and Glut3, in the Mammalian Plasma Membrane." Thesis, University of Skövde, School of Life Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-2330.

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Glucose is a monosaccharide and fuel for body, it cannot pass through membrane by simple diffusion so, integral transmembrane proteins named glucose transporters (Gluts) are involved in the regulation of the movement of glucose between the extracellular and intracellular spaces within the body. GLUT1 and GLUT3 have previously been shown by cold detergent extraction methods to reside in distinct plasma membrane domains in non-polarized mammalian cells, with GLUT1, but not GLUT3, residing  in detergent-resistant membrane (DRM) domains. To confirm this observation under less invasive conditions, molecular fusion tags are inserted in the first external loop in Glut1 with biotin ligase acceptor peptide (BLAP) between Ser-55 and Ile-56 and in Glut3 with Acyl carrier peptide (ACP) in between Val-57 and Leu-58 respectively. These Glut fusion proteins will be used in order to confirm these observations by fluorescence recovery after photobleaching (FRAP) and single molecule fluorescence microscopy in live cells. hGLUT1-EGFP, hGLUT1 (AgeI)-EGFP recombinants were constructed and transfected human embryonic kidney cells (HEK-293) quantum dot images supports the fact that EGFP transfected cells uniformly and is distributed in the cell cytoplasm, hGLUT1-EGFP transfected cells and is localized to the cell membrane and hGLUT1 (AgeI)-EGFP transfected cells and located to the plasma membrane with high intensity.

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Bourouis, Marc. "Etude fonctionnelle des sequences de controle des genes de glue de drosophile." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13061.

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Vasanthavada, Keshav. "Generation of cDNA chips from the black widow spider, latrodectus hesperus, for gene discovery and expression profiling using microarray technology, and molecular characterization of a novel silk glue protein." Scholarly Commons, 2005. https://scholarlycommons.pacific.edu/uop_etds/624.

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eDNA microarray technology has generated a tremendous amount of interest among biologists because of its promise to monitor the entire genome on a single chip, thus enabling researchers to have a better picture of the interaction among thousands of genes simultaneously. In the current study, this technology was used to print over 3,000 unknown genes from various silk glands of the black widow spider to profile their expression patterns and to identify novel candidates. Spiders are remarkable creatures because of their ability to make different silks, each with a specific function. Some of these silks have amazing mechanical properties, comparable to those of the finest synthetic materials. Several silk genes have been cloned from various spiders over the last few years, and the contribution of each of those genes in silk production has been identified. However, the majority of cellular and biochemical processes involved in silk manufacture remain a mystery. In our research, we attempt to identify genes that might be involved in silk assembly, on a global scale and investigate more about those genes and their interplay with other key biological molecules involved in silk manufacture. Our study showed that silking spiders for a certain period of time resulted in down-regulation of two important silk genes, ECP-1 and ECP-2. Both these genes are key molecules implicated for their role in maintaining the egg case architecture in the black widow spider.,-and we believe that these genes are also directly or indirectly involved in the manufacture of dragline silk. Microarray analyses also enable the discovery of several other interesting molecules, two of which could be accessory proteins involved in silk formation. Furthermore, in a separate study we also characterized a novel silk glue protein with unique ensemble repeats. In conclusion, we believe that the findings of this study will indeed be significant to silk researchers and material scientists alike and it will enhance our knowledge in understanding the mystery behind silk production.
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Mettling, Clément. "Utilisation de la transformation pour l'etude des elements regulateurs des genes de la glu chez drosophila melanogaster." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13152.

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Books on the topic "Molecular glues"

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Carter, Joshua D., Chenxiang Lin, Yan Liu, Hao Yan, and Thomas H. LaBean. DNA-based self-assembly of nanostructures. Edited by A. V. Narlikar and Y. Y. Fu. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780199533053.013.24.

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This article examines the DNA-based self-assembly of nanostructures. It first reviews the development of DNA self-assembly and DNA-directed assembly, focusing on the main strategies and building blocks available in the modern molecular construction toolbox, including the design, construction, and analysis of nanostructures composed entirely of synthetic DNA, as well as origami nanostructures formed from a mixture of synthetic and biological DNA. In particular, it considers the stepwise covalent synthesis of DNA nanomaterials, unmediated assembly of DNA nanomaterials, hierarchical assembly, nucleated assembly, and algorithmic assembly. It then discusses DNA-directed assembly of heteromaterials such as proteins and peptides, gold nanoparticles, and multicomponent nanostructures. It also describes the use of complementary DNA cohesion as 'smart glue' for bringing together covalently linked functional groups, biomolecules, and nanomaterials. Finally, it evaluates the potential future of DNA-based self-assembly for nanoscale manufacturing for applications in medicine, electronics, photonics, and materials science.
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Book chapters on the topic "Molecular glues"

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Alex, Jimi M., Francesca Guagnini, Kiefer O. Ramberg, Sylvain Engilberge, and Peter B. Crowley. "CHAPTER 7. Molecular Glues for Protein Assembly." In Monographs in Supramolecular Chemistry, 199–232. Cambridge: Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781788019798-00199.

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Elias, Hans-Georg. "The Mysterious Crazy Glue." In Mega Molecules, 40–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71900-4_5.

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Peineau, Stéphane, Vincent Degos, Catherine Verney, and Pierre Gressens. "GluNs Detection and Functions in Microglial Cells." In Methods in Molecular Biology, 253–63. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7321-7_14.

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Leung, Alexander K. C., Cham Pion Kao, Andrew L. Wong, Alexander K. C. Leung, Thomas Kolter, Ute Schepers, Konrad Sandhoff, et al. "Serous Otitis Media, Glue Ear." In Encyclopedia of Molecular Mechanisms of Disease, 1920–21. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8117.

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Mirkovic, Mihailo, and Raquel A. Oliveira. "Centromeric Cohesin: Molecular Glue and Much More." In Centromeres and Kinetochores, 485–513. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-58592-5_20.

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Harada, Harumi, and Ryuichi Shigemoto. "Immunogold Protein Localization on Grid-Glued Freeze-Fracture Replicas." In Methods in Molecular Biology, 203–16. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6352-2_12.

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Steindler, Dennis A. "Neurogenic Astrocytes and Their Glycoconjugates: Not Just “Glue” Anymore." In Methods in Molecular Biology, 9–22. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-452-0_2.

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Frere, Geordon A., Elvin D. de Araujo, and Patrick T. Gunning. "Emerging mechanisms of targeted protein degradation by molecular glues." In Methods in Cell Biology. Elsevier, 2022. http://dx.doi.org/10.1016/bs.mcb.2022.01.001.

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Maneiro, M., E. De Vita, D. Conole, C. S. Kounde, Q. Zhang, and E. W. Tate. "PROTACs, molecular glues and bifunctionals from bench to bedside: Unlocking the clinical potential of catalytic drugs." In Progress in Medicinal Chemistry, 67–190. Elsevier, 2021. http://dx.doi.org/10.1016/bs.pmch.2021.01.002.

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Atkins, Peter. "Stringing Along: Radical Polymerization." In Reactions. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199695126.003.0018.

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Perhaps the most striking observable change brought about by chemistry as applied to the everyday world is in the texture of objects. Until the early twentieth century objects were manufactured from metal, wood, and animal and plant fibres. Today, synthetic polymers, in the vernacular ‘plastics’, are ubiquitous and have changed not only the appearance of the world but also its feel. Polymers (from the Greek words for ‘many parts’) are made by stringing together small molecules, the ‘monomers’, into long chains or extensive networks. Thus, polyethylene (less formally polythene) is a chain of linked ethylene molecules, and polystyrene is a chain of linked styrene molecules. In some instances, two or more different types of monomer molecules are used to form the polymer. Thus, one form of nylon is a chain in which the alternating links are of two different compounds. There are two main ways of linking molecules together, one involving radicals (Reaction 12) and the other not. In this section I shall introduce you to radical polymerization and treat the other kind in Reaction 14. Polyethylene and its cousins are made by the radical method, and I start with them. An ethylene molecule (1, formally, ethene) is written H2C=CH2, the double bar denoting a ‘double bond’. This is the first time I have needed to introduce you to a double bond, but it will turn out to be a crucial feature of all the monomers in this section. A double bond consists of two ordinary bonds linking the same two atoms. Because each bond consists of a shared pair of electrons acting as glue between two atoms, a double bond consists of two such pairs. Although a double bond between two C atoms is stronger than a single bond between C atoms, it is not twice as strong because the two pairs of electrons struggle for the best position and tend to push each other out of the ideal location for bonding. One consequence is that a molecule can acquire lower energy by giving up one of the pairs of electrons in the double bond and forming more single bonds with other atoms.
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Conference papers on the topic "Molecular glues"

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Pasrija, Ritu, Sunita Srivastava, S. K. Tripathi, Keya Dharamvir, Ranjan Kumar, and G. S. S. Saini. "Molecular dynamic simulations with glue potentials." In INTERNATIONAL CONFERENCE ON ADVANCES IN CONDENSED AND NANO MATERIALS (ICACNM-2011). AIP, 2011. http://dx.doi.org/10.1063/1.3653718.

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Dohno, Chikara, Shin-nosuke Uno, and Kazuhiko Nakatani. "Photoswitchable molecular glue for hybridization of nucleic acids." In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112320.

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Golji, Javad, and Mohammad R. K. Mofrad. "Focal Adhesion Mechanotransduction: Molecular Events Leading to Vinculin Activation." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19711.

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Focal adhesions are formed as a molecular glue linking cytoskeletal actin filaments to the extracellular matrix (ECM). They are formed at the site of mechanical stimulation (1) and involve and initial recruitment of talin and vinculin to ECM bound integrin molecules at the site of external stimulation. Talin recruitment and its force-induced activation and subsequent interaction with vinculin have been extensively studied (2–4). Vinculin is natively in an auto-inhibited conformation and its activation involves removal of a steric hindrance preventing binding of Vt with actin (5) (Figure 1). Several hypotheses have been put forth regarding vinculin activation and its subsequent interaction with actin: 1) vinculin activation requires only interaction with talin at domain 1 (D1) (6), 2) a simultaneous interaction with both actin and talin is necessary to achieve vinculin activation (7), 3) once activated vinculin interacts with actin via an electrostatic interaction between Vt and two regions on F-actin (5). Each of these hypotheses is evaluated through molecular dynamics simulation and analysis.
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Xia, Feng, Zhenpeng Zhang, Heyu Wang, Zhonglei Li, Boxue Du, Runan Feng, and Lin Zheng. "Molecule Diffusion Behaviors of Waterproof Glue into Silicone Rubber Insulation of Submarine Cable Joints Base on Molecular Dynamic Simulation." In 2020 IEEE International Conference on High Voltage Engineering and Application (ICHVE). IEEE, 2020. http://dx.doi.org/10.1109/ichve49031.2020.9279993.

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Cosby, Neal C., Kristin M. Riching, Sarah Mahan, Elizabeth A. Caine, Danette L. Daniels, and Marjeta Urh. "Abstract 5230: Real-time monitoring of PROTAC and molecular glue targeted degradation in living cells." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-5230.

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Zhang, Sophia, Magdalena Dragan, Nicole Potter, Everett Henry, and Harris Zhang. "1152 In vitro anticancer and immunomodulatory activities of a novel molecular glue compound NBT-018." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.1152.

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Ainscow, Edward K., Adrian Campbell, Michael Cripps, Robert Workman, Stuart Thomson, Kam Chohan, Damien Crepin, et al. "Abstract P051: Identification of an orally bioavailable dual Cyclin K glue degrader - CDK12/13 inhibitor." In Abstracts: AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; October 7-10, 2021. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1535-7163.targ-21-p051.

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Wang, Heyu, Zhonglei Li, Boxue Du, Mingsheng Fan, Shuofan Zhou, and Zhuoran Yang. "Diffusion Behavior of Waterproof Glue into Silicone Rubber Insulation of Submarine Cable Joints Based on Molecular Dynamics Simulation." In 2020 IEEE 3rd International Conference on Dielectrics (ICD). IEEE, 2020. http://dx.doi.org/10.1109/icd46958.2020.9341972.

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Gavory, Gerald, Bernhard Fasching, Debora Bonenfant, Amine Sadok, Ambika Singh, Martin Schillo, Vittoria Massafra, et al. "Abstract LBA004: Identification of GSPT1-directed molecular glue degrader (MGD) for the treatment of Myc-driven breast cancer." In Abstracts: AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; October 7-10, 2021. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1535-7163.targ-21-lba004.

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Taylor, R. T., S. Mahajan, O. Scherman, T. Lee, R. Esteban, J. Aizpurua, and J. J. Baumberg. "Discrete plasmons in Au nano-assemblies for SERS: Fabricating rigid sub-nm junctions with molecular ‘cucurbituril’ glue." In 2011 13th International Conference on Transparent Optical Networks (ICTON). IEEE, 2011. http://dx.doi.org/10.1109/icton.2011.5970898.

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