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Dissertations / Theses on the topic 'Molecular diagnostic tool'

Author: Grafiati

Published: 6 September 2023

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1

Mohamed, Moumin Neima. "DEVELOPING A MOLECULAR TOOL KIT FOR DIAGNOSTIC PCR." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-392205.

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ABSTRACT The aim of this study is develop and test an inexpensive molecular tool kit to be used for diagnostic PCR for diseases such as Leber hereditary optic neuropathy (LHON) and Cystic fibrosis(CF). By developing and optimizing recombinant Taq polymerase and making a DNA size ladder from plasmids pPSU1 and pPSU2 the financial cost for the tool kit would be reduced significantly compared to the commercial components. With an inhouse method both the recombinant Taq polymerase and the pPSU1 and pPSU2 plasmids were purified from the E.coil strain DH5-α. Thereafter to analyse the components of t

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Menmuir, Sheena. "Visible spectroscopy as a sensitive diagnostic tool for fusion plasmas." Licentiate thesis, KTH, Physics, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-572.

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<p>To further the understanding and knowledge about fusion plasmas and their behaviour during different conditions, it is important to be able to collect information about the plasma and the processes occurring within it. Visible spectroscopy, or the study of the visible wavelength light emitted by the plasma, is a useful tool in this search for knowledge.</p><p>This thesis is based on experiments where visible wavelength light has been measured and analysed in order to determine quantities about the emitting source. Doppler shift measurements of spectral lines have been utilised to determine

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Christopeit, Tony. "Protein Interaction Studies with Low Molecular Weight Ligands : Applications for Drug Discovery, Basic Research and Diagnostic Tool Design." Doctoral thesis, Uppsala universitet, Institutionen för kemi - BMC, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-188328.

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In this thesis, the interactions between different proteins and small ligands were characterized by surface plasmon resonance spectroscopy (SPR) and fluorescence resonance energy transfer (FRET) based assays. For the C-reactive protein (CRP), a new type of artificial binder was identified which allows designing diagnostic assays superior to commonly used standard assays. Furthermore, an interaction study with the endogenous ligand phosphocholine revealed the importance of the avidity of pentameric CRP for the distinction of different types of lipid membranes. The interaction study with calc

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Flores, Carolina. "Cassava Bacterial Blight : development of a performant molecular detection tool and diversity analysis of Xanthomonas axonopodis pv. manihotis populations in Venezuela." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT161.

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Le manioc (Manihot esculenta L. Crantz) est cultivé dans toute la zone intertropicale. Compte tenu de ses utilisations potentielles, le développement de la culture du manioc a considérablement augmenté au niveau mondial, mais il est encore considéré comme une culture de subsistance en particulier dans les régions pauvres où il est cultivé par les petits producteurs. La production du manioc est fortement contrainte par des facteurs biotiques et abiotiques, dont la bactériose vasculaire du manioc (CBB) et la nécrose bactérienne du manioc (CBN) qui sont deux maladies causées par les bactéries Xan

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CHIACCHIO, TERESA. "New molecular diagnostic and immunological tools for tuberculosis research." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/916.

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Tuberculosis (TB) remains one of the world’s leading causes of mortality due to a single infectious agent, with approximately 1.5 million deaths and 9.2 million new cases per year as estimated in 2006. It is assumed that about 5-10% of individuals infected with M. tuberculosis develop TB and the remaining 90-95% contain M. tuberculosis through their immune systems, but have a latent tuberculosis infection (LTBI). To effectively control TB, it is essential to detect individuals with LTBI and to reliably diagnose active TB. Conventional TB diagnosis continues to rely on smear microscopy a

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Ebai, Tonge. "Development of Enhanced Molecular Diagnostic Tools for Protein Detection and Analysis." Doctoral thesis, Uppsala universitet, Molekylära verktyg, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320380.

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Improved diagnosis, prognosis and disease follow-up is a fundamental procedure and a constant challenge in medicine. Among the different molecular biomarkers, proteins are the essential regulatory component in blood; hence, by developing enhanced specific and sensitive molecular tools will gives great insight into the different processes in disease treatment. In this thesis, we build on the proximity ligation assay to develop and apply new adaptable methods to facilitate protein detection. In paper I, I present a variant of the proximity ligation assay (we call PLARCA) using micro titer plat

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Fluegel, Amanda M. "Validation of diagnostic assays and development of molecular epidemiological tools for brucellosis." Laramie, Wyo. : University of Wyoming, 2008. http://proquest.umi.com/pqdweb?did=1594477821&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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Holzapfel, Marion. "De l’épidémiologie moléculaire aux analyses fonctionnelles de Brucella chez les ruminants, une approche intégrée pour l’identification et l’étude de la diversité phénotypique d’un genre génétiquement homogène." Thesis, Paris Est, 2018. http://www.theses.fr/2018PESC1141.

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La brucellose est une zoonose causée par le genre bactérien Brucella (B.) dont l’incidence mondiale est estimée à 500 000 cas humains par an. Le réservoir est animal, touchant principalement les espèces de rente. Les espèces les plus importantes pour l’Homme sont B. melitensis, B. abortus et B. suis qui partagent plus de 90% d’identité de séquence. Bien qu’elles soient très apparentées sur le plan génétique, elles présentent une diversité de caractéristiques phénotypiques, de préférence d’hôte et de pathogénicité. L’homogénéité génétique de ces espèces peut apparaître comme un atout pour le dé

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9

Lopes, Jéssica Sousa. "FTIR, a potential tool to dementia diagnosis trough analysis of plasma." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/16149.

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Mestrado em Biomedicina Molecular<br>Nowadays it is still difficult to perform an early and accurate diagnosis of dementia, therefore many research focus on the finding of new dementia biomarkers that can aid in that purpose. So scientists try to find a noninvasive, rapid, and relatively inexpensive procedures for early diagnosis purpose. Several studies demonstrated that the utilization of spectroscopic techniques, such as Fourier Transform Infrared Spectroscopy (FTIR) and Raman spectroscopy could be an useful and accurate procedure to diagnose dementia. As several biochemical mechanisms rela

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10

Englund, Stina. "Molecular biology techniques as a tool for detection and characterisation of Mycobacterium avium subsp. paratuberculosis /." Uppsala : Dept. of Veterinary Microbiology, Swedish Univ. of Agricultural Sciences ([Institutionen för veterinärmedicinsk mikrobiologi], Sveriges lantbruksuniv.), 2002. http://epsilon.slu.se/avh/2002/91-576-6366-1.pdf.

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Dzien, Piotr. "The development of novel tools for in vivo molecular imaging using hyperpolarised ¹³C labelled molecules and ¹³C magnetic resonance spectroscopy and spectroscopic imaging." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708714.

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12

Craven, Thomas Henry John. "Resolving uncertainty in acute respiratory illness using optical molecular imaging." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29507.

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Ventilator associated pneumonia (VAP) and acute respiratory distress syndrome (ARDS) are two respiratory conditions unique to mechanically ventilated patients. The diagnosis of these conditions, and therefore any subsequent treatment, are befuddled by uncertainty. VAP rates vary considerably according to the diagnostic or surveillance criteria used. The pathogenesis of ARDS is well understood but when the internationally agreed consensus criteria are employed, the histological hallmarks are absent about half the time, indicating a disconnection between the clinical diagnosis and what is known

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Gomgnimbou, Kireopori michel. "Nouvelles méthodes de diagnostic, de contrôle et de surveillance de la tuberculose à bacilles sensibles ou multirésistants dans les pays à forte co-infection au VIH : applications en Santé Publique." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112210.

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La tuberculose est une maladie ancienne et ré-émergente qui constitue un véritable problème de santé publique dans le monde. L’émergence de la tuberculose à souches de M. tuberculosis multirésistantes et ultrarésistantes aux antituberculeux en plus de la pandémie du VIH/Sida, représentent un défi majeur dans la lutte contre la tuberculose pour son contrôle et son élimination. Ce contrôle de la tuberculose nécessite des mesures en santé publique et au niveau de l’individu. Ces mesures concernent la disponibilité et l’accessibilité à des tests de diagnostic rapides, des traitements efficaces et

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Hernández-Neuta, Iván. "Nucleic acid analysis tools : Novel technologies and biomedical applications." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-146334.

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Nucleic acids are fundamental molecules of living organisms functioning essentially as the molecular information carriers of life. From how an organism is built to how it responds to external conditions, all of it, can be found in the form of nucleic acid sequences inside every single cell of every life form on earth. Therefore, accessing these sequences provides key information regarding the molecular identity and functional state of any living organism, this is very useful for areas like biomedicine, where accessing and understanding these molecular signatures is the key to develop strategie

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Rodríguez, Pérez Eduardo M. "Study of cow subclinical hypocalcemia and development of new tools for its diagnostic and prevention." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/323908.

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Les vaques de llet sofreixen pèrdues de calci (Ca) quan comença la lactació i poden veure’s afectades per la hipocalcèmia clínica (sèrum Ca < 6mg/dL) o subclínica (Ca < 8.5mg/dL). Donat que la incidència clínica és del 5%, el problema més rellevant es troba en els casos subclínics (SCHC) perquè tenen una prevalença més elevada. Aquests casos no poden ser tractats degut a la falta d’eines de diagnosi. Per tal d’estudiar l’impacte, les conseqüències i la regulació de SCHC, i per desenvolupar estratègies de diagnòstic i de prevenció, es van dur a terme quatre estudis. Al primer estudi, es va aval

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McGowan, Michael John. "Molecular regulators of smoltification and viral infection management tools for salmon aquaculture." Thesis, University of Stirling, 2018. http://hdl.handle.net/1893/28532.

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Accurate smoltification and disease management in Atlantic salmon (Salmo salar) are key issues for the aquaculture industry. Due to their anadromous lifecycle the transfer of salmon from fresh water (FW) to seawater (SW) is crucial to their survival; too early can cause mortality, too late can cause desmoltification and long-term health problems. Both scenarios can increase susceptibility to four viral diseases: Salmon alphavirus (SAV), Infectious salmon anemia virus (ISAV), orthoreovirus (PRV), and Piscine myocarditis virus (PMCV). They all show similar clinical and histopathological symptoms

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Krzywkowski, Tomasz. "iLocks: a novel tool for RNA assays with improved specificity." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-147734.

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The Central Dogma of molecular biology describes a framework for how genetic information is transferred in cells, placing RNA as a messenger between DNA and translated proteins. During the last years, interest in RNA research has grown tremendously due to the increasing understanding and recognition of the importance of RNA in regulation of gene expression, biochemical catalysis, and genome integrity surveillance. Most importantly, RNA content, unlike DNA, changes constantly, fine-tuning the cellular response to match the environmental conditions. There is a clear potential for RNA biomarkers,

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Ndlovu, Thando. "Comparison of diagnostic tools and molecular based techniques for the rapid identification of Escherichia coli and coliforms in contaminated river water." Thesis, Cape Peninsula University of Technology, 2013. http://hdl.handle.net/20.500.11838/794.

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Thesis submitted in fulfilment of the requirements for the degree Master of Technology: Environmental Health in the Faculty of Applied Sciences at the Cape Peninsula University of Technology, 2013<br>Water is an important daily requirement and in a clean, pure form, it promotes health and well-being. In addition to South Africa being one of the driest countries in the world, water availability is also being compromised by massive pollution of remaining water sources. The Berg- and Plankenburg Rivers are two of the surface water sources in the Western Cape, South Africa, which are highly pollut

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Rojas, Mencias Pablo David [Verfasser]. "In situ detection, molecular epidemiology, and improvement of molecular tools for the understanding and diagnosis of infections caused by spirochetes / Pablo David Rojas Mencias." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1148425233/34.

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Cadd, Verity Anne. "The study of molecular markers for the progression of Barrett's oesophagus to adenocarcinoma to identify markers that can be used as diagnostic tools." Thesis, Cranfield University, 2002. http://dspace.lib.cranfield.ac.uk/handle/1826/3689.

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Barrett's oesophagus is a complication of gastro-oesophageal reflux disease and is the single most important predisposing factor for the development of adenocarcinoma of the oesophagus. New molecular markers are needed for early diagnosis and to monitor disease progression. Telomerase is a ribonuclear protein with reverse transcriptase activity, which uses its own RNA component as a template for the addition of telomeric repeats to the end of chromosomes. Telomerase activity has been studied during the neoplastic progression of Barrett's oesophagus using a TRAP based ELISA technique, which fou

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Calvani, Nichola Eliza Davies. "Translocation of Fasciola hepatica via international livestock movements: development of ante-mortem molecular diagnostic tools for the identification of Fasciola spp. in livestock." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/22464.

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Fasciolosis caused by infection with Fasciola hepatica and Fasciola gigantica is a zoonotic disease of worldwide importance, with an estimated 91 million people considered at risk of infection and livestock losses expected to exceed US $3 billion/year. Despite the significant human and animal health impacts, no test is capable of ante-mortem Fasciola spp. differentiation in areas of parasite sympatry. The aim of this thesis was to design, validate and deploy a suite of highly sensitive molecular diagnostic tools for Fasciola spp. differentiation from faecal samples to enable ante-mortem screen

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NUNES, Mónica Susana Claudino. "Unraveling of Borrelia burgdorferi sensu lato genospecies diversity in Portugal towards the development of more efficient diagnostic tools for Lyme disease." Doctoral thesis, Instituto de Higiene e Medicina Tropical, 2016. http://hdl.handle.net/10362/20055.

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Ixodídeos (carraças de corpo-duro), são importantes vetores de agentes patogénicos, responsáveis por doenças emergentes como a doença de Lyme (DL). Esta zoonose é causada por espiroquetas do complexo Borrelia burgdorferi sensu lato (s.l.) transmitidas por carraças da espécie Ixodes ricinus, o principal vetor na Europa. A DL é uma doença multisistémica com diversas apresentações clínicas e diagnóstico complexo. Em Portugal é ainda pouco diagnosticada e a notificação, apesar de obrigatória, é escassa. A presente investigação teve como principal objetivo desenvolver ferramentas moleculares, nome

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Howson, Emma Lucy Anna. "The development and application of molecular tools for the diagnosis of foot-and-mouth disease in field and low-resource laboratory settings." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8607/.

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The requirements for prompt diagnosis of foot-and-mouth disease (FMD) during outbreaks, and the need to establish robust laboratory testing capacity within FMD-endemic countries, have motivated the development of point-of-care tests (POCTs) to support current diagnostic strategies. Despite numerous publications detailing the design of platforms and assays for this purpose, the majority have only been evaluated in laboratory settings, using protocols incompatible for use in challenging environments. To address this gap, this thesis describes the development of an end-to-end molecular toolbox fo

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Malan, Stefanie. "Real time PCR as a versatile tool for virus detection and transgenic plant analysis." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1921.

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Thesis (MSc (Genetics))--University of Stellenbosch, 2009.<br>ENGLISH ABSTRACT: South Africa is regarded as one of the top wine producing countries in the world. One of the threats to the sustainability of the wine industry is viral diseases of which Grapevine leafroll-associated virus 3 (GLRaV-3) and Grapevine virus A (GVA) are considered to be the most important and wide spread. Scion material is regularly tested for viruses; however scion material is often grafted onto rootstocks that have questionable phytosanitary status. Virus detection in rootstocks is challenging due to low and v

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Adamu, Robert. "Molecular and Functional Characterization of Onchocerca volvulus Gene Products (Ov58GPCR and Ov-DKR-1) in the Control of Human Onchocerciasis." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/279609.

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Onchocerciasis is a severely debilitating yet neglected tropical disease (NTD) currently affecting approximately 15.5 million people, including 12.2 million people with skin disease and 1.025 million with vision loss. The disease causes social stigma, generates and perpetuates poverty, and leads ultimately to irreversible unilateral or bilateral blindness if untreated. Consequently, onchocerciasis is a major impediment to socioeconomic development in addition to being a major public health concern in some African countries. Many control programs have been launched against the disease with mode

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Guimbang, Abanda Babette [Verfasser], and Alfons [Akademischer Betreuer] Renz. "Tick-borne pathogens in African cattle – novel molecular tools for diagnostics in epizootiology and the genetics of resistance / Babette Josiane Guimbang Abanda ; Betreuer: Alfons Renz." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1210484455/34.

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Guimbang, Abanda Babette Josiane [Verfasser], and Alfons [Akademischer Betreuer] Renz. "Tick-borne pathogens in African cattle – novel molecular tools for diagnostics in epizootiology and the genetics of resistance / Babette Josiane Guimbang Abanda ; Betreuer: Alfons Renz." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1210484455/34.

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VINCI, PAOLA. "From understanding the molecular basis of Graft-versus-Host Disease (GvHD), to new diagnostic tools and innovative treatments for improving the management of patients undergoing allogeneic Hematopoietic Stem Cell Transplantation (HSCT)." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50969.

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Allogeneic haematopoietic-stem-cell transplantation (HSCT) is the treatment of choice for many malignant and non-malignant disorders. The development of novel strategies such as donor leukocyte infusion, nonmyeloablative HSCT, and cord blood transplantation allowed expanding the indications for allogeneic HSCT over the last several years, especially among older patients. However, the major toxicity of allogeneic HSCT, Graft-versus-Host Disease (GvHD), remains a complication that limits its wider application. Despite advances in post-transplantation immunosuppressive therapy, GvHD remains a maj

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Chang, Chia-Hao, and 張家豪. "Evaluation of digital real-time PCR assay as a molecular diagnostic tool for single-cell analysis." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/ycm2d3.

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博士<br>國立臺灣大學<br>高分子科學與工程學研究所<br>106<br>In a single-cell study, isolating and identifying single cells are essential, but these processes often require a large investment of time or money. The aim of this study was to isolate and analyse single cells using a novel platform, the PanelChip™ Analysis System, which includes 2500 microwells chip and a digital real-time polymerase chain reaction (dqPCR) assay, in comparison with a standard RT-PCR (qPCR) assay. Through the serial dilution of a known concentration standard, namely pUC19, the accuracy and sensitivity levels of two methodologies were com

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Marques, Bruno Filipe Pinheiro. "Urine : a new tool for molecular diagnosis of chronic rejection in kidney transplantation?" Master's thesis, 2015. http://hdl.handle.net/10316/30340.

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Dissertação de mestrado em Biotecnologia Farmacêutica, apresentada à Faculdade de Farmácia da Universidade de Coimbra<br>Renal transplantation has become the treatment of choice for patients with end-stage renal disease. Recognizable improvements in early graft survival and long-term graft function have made kidney transplantation a more cost-effective alternative to dialysis. Moreover, the discovery of new immunosuppressive agents has made a significant impact on short-term graft survival. Despite these improvements a substantial portion of grafts develop progressive dysfunction and fail wit

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Callison, Scott Andrew. "Molecular tools for the study, diagnosis, and control of infectious bronchitis virus." 2003. http://purl.galileo.usg.edu/uga%5Fetd/callison%5Fscott%5Fa%5F200305%5Fphd.

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Thesis (Ph. D.)--University of Georgia, 2003.<br>Directed by Mark W. Jackwood. Includes articles submitted to Avian diseases, Virus genes, and The journal of clinical microbiology. Includes bibliographical references.

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DURANTI, CLAUDIA. "Novel molecular tools in cancer therapy: diagnostic and therapeutic applications of antibodies targeting ion channels and receptors." Doctoral thesis, 2017. http://hdl.handle.net/2158/1077157.

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Immunotherapy has had a revolutionary impact on cancer treatment, providing valuable tools to be used in combination or as an alternative to chemotherapy (Weiner G.J., 2015). Such wide success has been demonstrated by the fact that, since 1997, twelve monoclonal antibodies have been approved by the FDA for the treatment of a variety of solid tumors and haematological malignancies, along with an increasing number of new antibodies that are now being tested at different stages of clinical trials (ClinicalTrials.gov). Nevertheless, there are limitations to the use of monoclonal antibodies

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Leão, Célia Cristina Fialho. "Molecular tools in the diagnostic and epidemiology of infections caused by members of Mycobacterium avium Complex." Doctoral thesis, 2015. http://hdl.handle.net/10362/16513.

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Mycobacterium avium Complex (MAC) comprises microorganisms that affect a wide range of animals including humans. The most relevant are Mycobacterium avium subspecies hominissuis (Mah) with a high impact on public health affecting mainly immunocompromised individuals and Mycobacterium avium subspecies paratuberculosis (Map) causing paratuberculosis in animals with a high economic impact worldwide. In this work, we characterized 28 human and 67 porcine Mah isolates and evaluated the relationship among them by Multiple-Locus Variable number tandem repeat Analysis (MLVA). We concluded that Mah po

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MIGLIORINI, DUCCIO, PAOLO CAPRETTI, and ALBERTO SANTINI. "Phytophthora in natural and anthropic environments: new molecular diagnostic tools for early detection and ecological studies." Doctoral thesis, 2016. http://hdl.handle.net/2158/1028950.

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L’efficacia di PCR quantitativa basata su una sonda TaqMan specifica per il genere è stata confermata come preciso strumento di rilevamento di DNA di Phytophthora su suolo artificialmente infettato, in suolo di invasatura contaminato proveniente da vivaio ed in campioni di trappole aeree. Nessuna quantificazione di DNA è avvenuta dopo due settimane dalla morte indotta del patogeno e, in confronto con i metodi di isolamento tradizionali, è stata dimostrata una significativa maggiore efficienza come strumento diagnostico. La fluttuazione stagionale di Phytophthora in aria è stata quantificata e

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ZAMPIERI, ROBERTA. "Plant viruses: the many aspects of fascinating nano-biotechnological tool." Doctoral thesis, 2017. http://hdl.handle.net/11562/961367.

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I capsidi virali sono strutture stabili e robuste composte da multiple copie di una o più tipi di subunità proteiche organizzate con simmetrie ordinate (icosaedriche o filmentose). I capsidi virali possono essere prodotti in sistemi vegetali in consistenti quantità sia tramite l’infezione delle piante sia tramite l’espressione delle subunità capsidiche. Data la semplicità e l’elevata stabilità, le Chimeric Virus Particles (CVPs) e le empty Virus Like Particles (eVLPs) hanno attirato l’attenzione della comunità scientifica per lo sviluppo di reagenti che possono trovare impiego nell’ambito dell

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Troiano, Annaelena. "FUNCTIONAL ANALYSIS OF P63-YB1 INTERACTION IN NORMAL AND TRANSFORMED EPITHELIAL CELLS: DEVELOPMENT OF NOVEL MOLECULAR TOOLS FOR SQUAMOUS CANCER DIAGNOSIS AND THERAPY." Tesi di dottorato, 2015. http://www.fedoa.unina.it/10314/1/Troiano_Annaelena_27.pdf.

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Skin homeostasis is dependent on a tightly coordinated network of signaling pathways, resulting in a spatial and temporal balance of proliferation, growth arrest, differentiation, senescence and apoptosis. The knowledge of mechanisms that regulate keratinocyte growth and proliferation is attractive for several biotechnological fields, such as cosmetics, tissue engineering and skin regeneration. DNp63alfa, as critical pro-proliferative factor and marker of epidermal stemness, is essential for morphogenesis of organs/tissues developing by epithelial-mesenchimal interactions such as the epiderm

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