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Dissertations / Theses on the topic 'Modulation of cell size'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

GOTTI, LAURA. "Nutritional modulation of cell size at s phase initiation in the buddine yeast saccharomyces cerevisiae: a role for glucose sensing and the cyclin dependent kinase inhibitor." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19573.

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The budding yeast Saccharomyces cerevisiae is a model organism for studies on cell cycle. For the survival of this cells a tight coordination of cell growth and division occurs at Start, a regulatory area of the cell cycle positioned immediately before beginning of S phase, at the G1-S boundary. Start is the event, or set of events, that commits a cell to a round of division. This mechanism is based on achieving of a critical cell size (protein content per cell at the onset of DNA replication, Ps) to enter into S phase. Ps increases in proportion with ploidy and is modulated by nutrients. In

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2

Hubatsch, Lars. "Interplay between cell size and cell polarity." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10055636/.

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Cell polarity is a fundamental phenomenon underlying processes such as asymmetric cell division, tissue homeostasis and directed cell migration. In metazoans, the conserved PAR (-titioning defective) protein network polarizes cells with different shapes and sizes. Here, I investigate whether cell size influences the polarity pattern set up by the PARs. PAR polarity is typically achieved by localizing different sets of antagonizing proteins to opposing membrane domains. Antagonism ensures that mixing of the two species is restricted to a region between the two domains. Theoretically, this can b

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3

Maguire, Sharon Marie. "Germ cell modulation of Sertoli cell function." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/20662.

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The aim of this work was to assess the influence of germ cells on the expression of selected Sertoli cell mRNAs. To this end, adult rats were treated with 650mg/kg methoxyacetic acid (MAA) to induce the specific depletion of >80% of pachytene and later spermatocytes from most tubules, and expression of selected Sertoli cell mRNAs was then assessed at various times after treatment when particular germ cell types were depleted selectively (see Bartlett <I>et al</I>. 1988; Allenby <I>et al</I>., 1991). Studies on the expression of cyclic protein 2(CP-2) mRNA supported the hypothesis that germ cel

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4

Cadart, Clotilde. "Cell size homeostasis in animal cells." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS103/document.

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Le mécanisme d’homéostasie de taille chez les cellules animales est très peu compris actuellement. Cette question est pourtant d’un intérêt majeur car le maintien de l’homéostasie de taille dans une population de cellules prolifératives doit se faire par une coordination entre la croissance et la division. Chez la levure S. pombe, il a ainsi été montré que la taille est une information cruciale pour déclencher l’entrée en mitose (Fantes, 1977). Chez plusieurs bactéries et les cellules filles de la levure S. cerevisiae au contraire, de récentes études ont au contraire montré que l’homéostasie d

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5

Ricolo, Delia. "Cytoskeletal modulation of single-cell branching." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/404782.

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The embryonic tracheal system of Drosophila melanogaster consists of a network of interconnected epithelial tubes of different size and architecture characterized by different cellular mechanisms of tube formation. The main branches of the Drosophila tracheal system have an extracellular lumen because their cells fold to form a tube. However, terminal cells (TCs), specialized cells designed to connect the tracheal system to target tissues, form unicellular branches by generating of a subcellular lumen. This topology of unicellular tubes is a good model to clarify the mechanisms that orchestrat

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6

Forsythe, Paul. "The modulation of mast cell activity." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388087.

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7

Watt, A. P. "The modulation of mast cell activity." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368527.

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8

Luizet, Jean-Baptiste. "Host Cell modulation by Brucella effectors." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1157.

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Brucella abortus est une bactérie pathogène responsable d’une zoonose ré-émergente causant plus de 500 000 décès par an. Brucella est une bactérie à Gram négative facultative intracellulaire capable d’infecter un grand spectre de cellules différents en entrant par phagocytose ou macropinocytose. Une fois à l’intérieur de la cellule, Brucella est retrouvée dans une vacuole doublement membranée appelée Brucella-containing vacuole (BCV). Brucella va alors interagir partiellement avec les différents compartiments endosomaux et lysosomaux afin d’établir sa niche réplicative au sein du réticulum end

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9

Brown, Marena Dessette. "Sickle cell-endothelial interactions : modulation of cell adhesion molecule expression." Diss., Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/11306.

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10

Wu, Chia-Yung. "Control of gene expression by cell size." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57564.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student submitted PDF version of thesis.<br>Includes bibliographical references.<br>Polyploidy, increased copy number of whole chromosome sets in the genome, is a common cellular state in evolution, development and disease. Polyploidy enlarges cell size and alters gene expression, producing novel phenotypes and functions. Although many polyploid cell

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11

Crotti, Pablo. "Phenotypic variability, cell size and population fitness." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/43964.

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In all biological systems, phenotypes are quantitative measures of an organism's traits. To understand the relation between a genotype and phenotypes, the influence of genetic perturbations, such as gene deletions, on phenotypes is studied. Although it is common practice to look at the mean value of phenotypes to detect changes, it is less common to model such modifications by considering phenotypic variability. However, phenotypic variability could also contain important information about the phenotype-genotype map. Also, phenotypic variability is a determinant of an organism's robustness and

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12

Burgoyne, Celia Helen. "Glucose modulation of endothelial cell in vitro." Thesis, University of Hull, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402798.

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13

Martin, Ashley Diane. "Modulation of endothelial cell characteristics by pericytes." Thesis, University of Ulster, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287133.

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14

Iqbal, Z. "Electrochemical modulation of sickle cell haemoglobin polymerisation." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444279/.

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Sickle cell haemoglobin differs from normal haemoglobin by a single amino acid in its chain. This amino acid replacement, from glutamic acid to valine, causes polymerisation of proteins into defined long insoluble fibres with a typical diameter of 21.5 nm. The polymerisation is triggered by the formation of deox haemoglobin from oxyhaemoglobin in low oxygen partial pressures, which results in a conformational change in the secondary structure of the protein. Pathogenesis in sickle cell disease depends on the polymerisation and gelation of deoxygenated HbS molecules. In this work, an electroche

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15

Mangani, Christian. "Peptides and polymers for stem cell modulation." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/17909.

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One of the requisites for a growth factor and a biomaterial in tissue engineering, cell therapy and regenerative medicine is the ability to control cell fate. Cells exist in a complex micro-environment consisting of extra-cellular matrix, growth factors, together with adjacent cells. Stem cell culture and modulation remains a challenge due to insufficient, undefined and costly culture systems. This thesis describes synthetic approaches that can modulate stem cell fate by the identification of new synthetic substrates for the growth of cancer, embryonic stem cells and potential short peptide se

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16

Muñoz, Frances M. "Calcium Modulation of PARP-mediated Cell Death." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/347337.

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Many pathological conditions, including renal disease, are associated with oxidative stress. 2,3,5-tris(Glutathion-S-yl)hydroquinone (TGHQ), a potent nephrotoxic and nephrocarcinogenic metabolite of benzene and hydroquinone, generates reactive oxygen species (ROS), can cause DNA strand breaks, and the subsequent activation of DNA repair proteins, including poly(ADP-ribose) polymerase (PARP)-1. Under robust oxidative damage, PARP-1 is hyper-activated, which causes elevations in intracellular calcium concentrations (iCa²⁺), NAD⁺ and ATP depletion, and ultimately necrotic cell death. The role of

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17

Bruckner, Markus [Verfasser]. "Modulation of Dendritic Cell Behaviour / Markus Bruckner." Konstanz : Bibliothek der Universität Konstanz, 2011. http://d-nb.info/1041832877/34.

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18

McSherry, Iain Neil. "Endothelial cell modulation of smooth muscle contraction." Thesis, University of Bath, 2005. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423481.

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19

Sharma, Manu. "Host cell death modulation by Chlamydia trachomatis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16253.

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Chlamydien durch die Modulation spezifischer Wirtszellproteine verschiedene Wege der Apoptose verhindern können. Mcl-1 und cIAP-2 erwiesen sich als bedeutende Faktoren, die durch die Infektion hochreguliert und absolut notwendig für die Inhibierung der Apoptose durch Chlamydien waren. Hochregulation der Mcl-1 Expression führte zu einem Block im apoptotischen Weg oberhalb der Mitochondrien. cIAP-2 zusammen mit anderen Inhibitor of Apoptosis Proteins (IAP) verhinderten die Aktivierung von Caspase-3, denfinalen Schritt in der apoptotischen Kaskade. Weiterhin wurde beobachtet, dass die Aktivierun

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20

Grangeray-Vilmint, Anais. "Modulation of cerebellar Purkinje cell discharge by subthreshold granule cell inputs." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ023/document.

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La décharge des cellules de Purkinje (CP), neurone de sortie du cortex cérébelleux, joue un rôle majeur dans le contrôle moteur. Les CP reçoivent des entrées excitatrices provenant des cellules des grains (CG), lesquelles génèrent également une inhibition antérograde sur les CP via l’activation d’interneurones de la couche moléculaire (IN). Lors de ma thèse, j’ai étudié l’influence simultanée de la balance excitation-inhibition (E/I) et des plasticités à court terme aux synapses CG-IN-CP sur la décharge des CP, par des techniques d’électrophysiologie, d’optogénétique et de simulation. Ces trav

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21

Wang, Wei. "Modulation of immune cell responses by small cell lung cancer cells." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/modulation-of-immune-cell-responses-by-small-cell-lung-cancer-cells(7bdc85c2-acd8-4f13-9d2b-e2ce07d1567b).html.

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Small Cell Lung Cancer (SCLC) accounts for 15-20% of all lung cancers and kills at least one person every 2 hours in the UK. There is no effective treatment and overall 2-year survival is less than 5%. Patients with SCLC have poorly understood local and systemic immune defects. Previous studies have shown several important defects in cell-mediated immune responses in patients with SCLC. A better understanding of interactions between SCLC tumour cells and immune cells may lead to the development of novel therapeutic approaches. There is increasing recognition that immunological biomarkers may a

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22

Matsiaka, Oleksii. "New mathematical models for cell biology assays incorporating realistic cell size dynamics." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/198192/1/Oleksii_Matsiaka_Thesis.pdf.

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This thesis provides novel insights into several contemporary problems in the mathematical biology involving migration of living cells. Primarily, we focus on cell motility and how dynamic changes in cell size affect collective cell migration. Additionally, this thesis investigates the importance of cellular heterogeneity and how it might affect the choice of modelling techniques we use to describe in vitro cell cultures.

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23

Martínez, Segura Amalia. "Coordination between cell size and global gene expression." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/62906.

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All cells change size during the cell cycle, as they have to double their mass in order to produce two equally sized daughter cells. For biochemical reactions to work as intended in a changing volume, the reactants’ concentration should be stable. Data shows that the total mass of RNA and protein per cell are proportional to cell size. Expression data also shows a coordinated increase of the majority of the transcripts when there is an increase in average cell length \citep{Zhurinsky2010}, the mechanism behind it is still poorly understood. In this study I took advantage of a previously descri

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24

Ginzberg, Miriam Bracha. "Size Control and Uniformity in Animal Cells." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17463956.

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The homogeneity in cell size observed in many normal proliferating tissues, and the contrasting size disparities characteristic of several cancers, suggest that control mechanisms coordinate growth and cell cycle progression, but the existence of such mechanisms has not been firmly established. To address this problem, we used quantitative fluorescence microscopy to measure cell cycle position, total protein content, and the level of cell growth regulators such as phosphorylated ribosomal protein S6, in tandem in single cells. Measurements were made on large numbers of cells drawn from prolife

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25

Pinent, Armengol Montserrat. "Adipose cell metabolism modulation by red wine procyanidins." Doctoral thesis, Universitat Rovira i Virgili, 2005. http://hdl.handle.net/10803/8650.

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Flavonoids, and more specifically, red wine procyanidins, have many beneficial effects<br/>against pathologies such as cardiovascular heart disease and related illnesses. Although<br/>adipose tissue has a central role in some of these pathologies, including obesity and diabetes,<br/>there is a lack of information about the effects of procyanidins on this tissue. This thesis<br/>addresses this question. The effects of a grape seed procyanidin extract (GSPE) on the lipid<br/>and glucose metabolism of adipocytes were evaluated by taking the 3T3-L1 cell line as a<br/>model of study. Results show t

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26

Ehigiator, Humphrey Nosayaba. "Immune modulation of B cell function by nematodes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0018/NQ57365.pdf.

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27

Saleh, A. W. "Modulation of fetal hemoglobin in sickle cell anemia." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=8498.

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28

Bundy, Ruth Eldeca. "Redox modulation of vascular cell injury and adaptation." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414511.

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29

Strong, Victoria. "Modulation of dendritic cell function by interleukin-10." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393790.

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30

Longhi, Maria Paula. "Modulation of CD4+ T cell responses by CD59a." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/56047/.

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CD59 is a GPI-anchored protein found in membrane microdomains known as lipid rafts. It is a complement regulator protein, which blocks the formation of the membrane attack complex by inhibiting binding of C9 to the C5-8 complex. Human CD59 has also been described as a co-stimulator of T cell activation. The aim of this project was to analyze the role of CD59 on T cell activation in vivo. For this purpose, anti-viral CD4+ T cell responses were analyzed in mice deficient in the mouse analogue of CD59 CD59a. Infection with recombinant vaccinia virus (rVV) and influenza virus, resulted in stronger

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31

Shepherd, Ruth Juliet Basten. "Modulation of endothelial cell properties in systemic sclerosis." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404587.

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32

Chen, Naiyan. "Cell-type specific cholinergic modulation of the cortex." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/84383.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Computational and Systems Biology Program, 2013.<br>Cataloged from PDF version of thesis. "September 2013." Page 126 blank.<br>Includes bibliographical references.<br>The cholinergic innervation of the neocortex by afferent fibers originating in the nucleus basalis (NB) of the basal forebrain is implicated in modulating diverse neocortical functions including information processing, cortical plasticity, arousal and attention. To understand the physiological basis of these brain functions during cholinergic modulation, it is critical to id

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33

Kovac, S. "Mechanisms and modulation of seizure induced cell death." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1383791/.

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Epilepsy, one of the most prevalent neurological diseases, is characterized by recurrent seizures, which are often poorly controlled by present treatments. Neuronal cell death, one of the complications of uncontrolled seizures, contributes substantially to the disease-burden through cognitive decline. This thesis explores mechanisms underlying neuronal death following seizure activity with a focus on mitochondria and ROS as major culprits of seizure induced neuronal cell death. By applying fluorescent dye imaging to glio-neuronal cell cultures, the first study examines mitochondrial mechanisms

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34

Moore, Anthony Norman. "Selenium modulation of gut epithelial cell stress responses." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3679.

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Selenium (Se) is an essential micronutrient necessary for human health. In humans, Se de ciency has been associated with in ammatory bowel disease (IBD) and increased risk of certain cancers, including colorectal cancer. Se has well established antioxidant and anti-in ammatory properties which are medi- ated, in part, though the actions of the selenoproteins, in which Se is present in the form of the amino acid selenocysteine (Sec). The cells of the gastrointestinal tract are exposed to stresses from pro-oxidative and hypoxic conditions, which have been suggested to be involved in the pathogen

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35

Kim, Sun Wook. "Modulation of Stem Cell Fate by Electrical Stimulation." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1383812480.

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36

Dobbs, Cathleen M. "Neuroendocrine modulation of anti-viral cell-mediated immunity /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487941504294026.

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37

Santiago, Joana Filipa Marques. "Modulation of sperm motility using cell-penetrating peptides." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22325.

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Mestrado em Biologia Molecular e Celular<br>The large number of unintended pregnancies worldwide due to the non-use or failure of contraceptive methods and the fact that male contraceptives are limited to condom and vasectomy, highlight the urgent need for the development of new contraceptive methods. The mechanism of sperm motility acquisition in the epididymis constitutes an ideal target for new pharmacological male contraceptives since only the post-testicular sperm maturation is affected. It is known that protein phosphatase 1 subunit gamma 2 (PPP1CC2), a PPP1 isoform only present i

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38

Wang, Kai. "Substrate Nanotopography and Stiffness Modulation of Cell Behavior." Thesis, University of North Texas, 2019. https://digital.library.unt.edu/ark:/67531/metadc1505286/.

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The physical characteristics (i.e., nanostructure and stiffness) of the extracellular matrix where cells reside have been shown to profoundly affect numerous cellular events in vivo and also been employed to modulate cell behavior in vitro, yet how these physical cues regulate cell behavior is still elusive. Therefore, we engineered a variety of nanotopographies with different shapes and dimensions, and investigated how the nanotopographical cue, through focal adhesions-cytoskeleton-nucleus pathway, affected cell phenotype and function. We further designed and fabricated well-defined substrate

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Keifenheim, Daniel L. "Cell Size Control in the Fission Yeast Schizosaccharomyces pombe: A Dissertation." eScholarship@UMMS, 2015. http://escholarship.umassmed.edu/gsbs_diss/784.

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The coordination between cell growth and division is a highly regulated process that is intimately linked to the cell cycle. Efforts to identify an independent mechanism that measures cell size have been unsuccessful. Instead, we propose that size control is an intrinsic function of the basic cell cycle machinery. My work shows that in the fission yeast Schizosaccharomyces pombe Cdc25 accumulates in a size dependent manner. This accumulation of Cdc25 occurs over a large range of cell sizes. Additionally, experiments with short pulses of cycloheximide have shown that Cdc25 is an inherently unst

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Gerrish, Kevin Edward 1965. "Modulation of Nb2 cell mitogenesis by peripheral benzodiazepine ligands." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/277200.

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In this study, we investigated the effects of the peripheral benzodiazepine ligands, Ro5-4864 (putative antagonist) and PK 11195 (putative antagonist) on prolactin stimulated mitogenesis in Nb2 cells. Ro5-4864 and PK 11195 at 10⁻⁹ M maximally enhanced prolactin stimulated mitogenesis. At 10⁻⁶ M Ro5-4864 inhibited prolactin stimulated mitogenesis. Clonazepam, a ligand for the central benzodiazepine receptor had no effect on mitogenesis. Interaction studies were undertaken to determine if Ro5-4864 and PK 11195 act on the same site. The ability of each ligand to enhance the mitogenic action of pr

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Mazade, Reece Eric. "Modulation Of Inner Retinal Inhibition With Light Adaptation." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/565903.

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The retina is able to adjust its signaling over a wide range of light levels. A functional result of this is increased visual acuity at brighter luminance levels, such as during the day, due to changes in the organization of retinal receptive fields. This process is commonly referred to as light adaptation. These organizational changes have been shown to occur at the level of the ganglion cells, the output neurons of the retina, which have shifts in their excitatory center-inhibitory surround receptive fields that increase their sensitivity to small stimuli. Recent work supports the idea that

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Garrison, Jennifer L. "Small molecule modulation of protein secretion." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3261264.

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Teixeira, de Matos Cristina. "Modulation of natural killer cell and T-cell functions by CD94/NKG2A receptors /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-846-0/.

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Miettinen, Teemu P. "On connections between Metazoan cellular metabolism and cell size." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/3cdc8663-1167-4a8b-ad5c-698c20695664.

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All animal cells maintain cell size homeostasis, where cell growth (increase in size) is balanced with proliferation (reduction in size via cell division). Yet, different cell types have different sizes and there are physiologically relevant situations where animal cells undergo major cell size changes. So how is cell size regulated? And why is cell size regulated? Are there specific cellular processes that have different functionality in different sized cells? This thesis investigates these questions from the perspective of cellular metabolism. Using a Cyclin dependent kinase 1 knockout mouse

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Silva, Michael Santos. "Flow cytometric of c-FLIPl-mediated regulation of cell cycle and cell population size." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22487.

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Mestrado em Bioquímica - Bioquímica Clínica<br>c-FLIP é uma proteína conhecida pela sua capacidade de se ligar ao DISC, onde compete com a procaspase-8 pela interação com FADD. No entanto, existem evidências que a sua isoforma longa consegue regular também o ciclo celular e mecanismos de proliferação. Para além disso, a atividade de c-FLIPL pode ser controlada por fosforilação. Assim, o objetivo deste estudo é perceber como a fosforilação no resíduo de serina 227 nesta proteína afeta a proliferação e ciclo celular. Neste estudo, observamos que a sobre-expressão de c-FLIPL com uma mutação de se

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46

Salako, Michael Albert. "Enteroviral modulation of host cell and drug-induced apoptosis." Thesis, University of Surrey, 2005. http://epubs.surrey.ac.uk/843342/.

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Coxsackievirus B4 (CVB4) is a common infection. Most cases are symptom-free but occasionally chronic sequelae emerge such as insulin-dependent diabetes mellitus, and dilated myocardiopathy and virus persistence is thought to contribute to these conditions. Persistent viruses frequently possess mechanisms that promote survival of the infected cell and inhibit apoptosis. Mitochondria play a central role in mediating apoptotic effects and may thus be targeted by viruses. Recently, poliovirus was shown both to inhibit apoptosis and to disrupt mitochondrial function and thus we have sought similar

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Liwski, Robert Stefan. "Modulation of T cell-mediated responses by Nippostrongylus brasiliensis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0020/NQ49276.pdf.

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48

Heijstek, Helena Cornelia. "Modulation of human dendritic cell function by therapeutic agents." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/64240.

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49

Szabat, Marta. "Characterization and modulation of adult pancreatic β-cell maturity". Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/27295.

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The functional maturation and dedifferentiation of β-cells is central to diabetes pathogenesis and to beta-cell replacement therapy. Despite its importance, the dynamics of adult β-cell maturation remain poorly understood because it has previously been difficult to study the process directly. A novel dual fluorescent reporter lentiviral vector was developed capable of tracking the differentiation status of single β-cells in culture. Using this labeling tool, an immature β-cell state was identified in adult primary human and mouse islets and beta-cell lines. The immature β-cell state was charac

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Nsiah, Barbara Akua. "Fluid shear stress modulation of embryonic stem cell differentiation." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/47552.

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Vascularization of tissue-engineered substitutes is imperative for successful implantation into sites of injury. Strategies to promote vascularization within tissue-engineered constructs have focused on incorporating endothelial or endothelial progenitor cells within the construct. However, since endothelial and endothelial progenitor cells are adult cell types and limited in number, acquiring quantities needed for regenerative medicine applications is not feasible. Pluriopotent stem cells have been explored as a cell source for tissue-engineered substitutes because of their inherent abili

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