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1

Kilmer, Kevin J., Robert Bateman, and Don Malzahn. "Techniques of Subjective Assessment: A Comparison of the SWAT and Modified Cooper-Harper Scales." Proceedings of the Human Factors Society Annual Meeting 32, no. 2 (October 1988): 155–59. http://dx.doi.org/10.1177/154193128803200233.

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This study examined two subjective mental workload assessment scales, the Subjective Workload Assessment Technique (SWAT) and the Modified Cooper-Harper (MCH) Scale. The purpose of this study was to make a direct comparison of the two scales in order to determine if both scales were equally sensitive to changes in task difficulty hence, workload. Forty introductory psychology non-aviator students were trained on an aviation like psychomotor dual-task experiment. Task difficulty was manipulated by presenting the subjects with three (low, moderate, high) levels of wind gust disturbance (turbulence) and requiring them to maintain an assigned altitude and airspeed, while responding to a visual choice reaction time secondary task. The data was analyzed using multivariate statistics. The results of the analysis found that both the SWAT and MCH were sensitive to changes in task difficulty. However, the MCH appeared to be less sensitive than the SWAT.
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2

Mansikka, Heikki, Kai Virtanen, and Don Harris. "Comparison of NASA-TLX scale, modified Cooper–Harper scale and mean inter-beat interval as measures of pilot mental workload during simulated flight tasks." Ergonomics 62, no. 2 (January 27, 2019): 246–54. http://dx.doi.org/10.1080/00140139.2018.1471159.

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Widyasti, Andhini Ayu, Sunardi Sunardi, and Tranggono Tranggono. "ANALISIS BEBAN KERJA BAGIAN PRODUKSI DENGAN METODE DEFENCE RESEARCH AGENCY WORKLOAD SCALE (DRAWS) DAN MODIFIED COOPER HARPER (MCH) DI PT. SENDANG BIRU TUBAN." JUMINTEN 2, no. 2 (March 31, 2021): 84–95. http://dx.doi.org/10.33005/juminten.v2i2.234.

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PT. Sendang Biru adalah perusahaan manufaktur penghasil bahan campuran pupuk salah satunya adalah clay. Dengan target produksi 100 ton tiap harinya dengan jam kerja hamper 24 jam dengan sistem kerja shift dan menggunakan alat produksi yang sama mengakibatkan sering terjadinya trouble mesin sehingga proses produksi terhambar dan terjadilah kerja lembur, selain hal tersebut beban kerja juga hal utama yang perlu diperhatikan. Penelitian ini menggunakan metode Defence Research Agency Workload Scale (DRAWS) dan Modified Cooper Harper (MCH) untuk mengukur beban kerja. Dimana pengukuran beban kerja secara umum menggunakan metode DRAWS akan dianalisis lebih lanjut penyebab terjadinya beban kerja dengan metode MCH. Didapatkan perbandingan beban kerja yang berbeda-beda setiap shiftnya yaitu shift 1 60,47%, shift 2 64,61% dan shift 3 70,32% (Overload) dan memiliki 6 aktivitas yang overload. Dengan variabel Input Demand tertinggi penyebab adanya beban kerja dan tergolong dalam beban kerja fisik (shift 1), Time Pressure sebagai beban kerja mental (shift 2),dan Time Pressure sebagai beban kerja mental (shift 3) .
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Kleiner, Brian M., Colin G. Drury, Joseph Sharit, and Sara J. Czaja. "Evaluating the Effects of Automation on the Human Operator." Proceedings of the Human Factors Society Annual Meeting 33, no. 11 (October 1989): 733–36. http://dx.doi.org/10.1177/154193128903301123.

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This study was designed to evaluate the symbiosis of human-machine systems with varying levels of automation. This paper focuses on the protocol methodology employed in the study. The approach required the use of both qualitative and quantitative techniques to derive a comprehensive evaluation of the human-machine system. Protocol Analysis supported by ethnographic software was used to evaluate the verbal transcripts. A qualitative process of code mapping and analysis was developed. The Modified Cooper-Harper scale was used to evaluate mental workload and objective measures of performance provided quantitative data of the system. The results confirmed the usefulness of a proposed classification scheme for human-machine systems. Using the methodology, human capabilities could be assessed against system demands for various configurations of a human-machine system. The importance of understanding the human's role in increasingly automated systems was again demonstrated.
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Charkhandaz Yeganeh, Reza, Iraj Alimohammadi, Jamileh Abolghasemi, Zabiolah Damiri, Bahar Parsazadeh, and Negar Rahmani. "Validity and reliability of Verbal Online Subjective Opinion (VOSO) and Modified Cooper-Harper scales in measuring of mental workload." Journal of Occupational Hygiene Engineering 3, no. 3 (December 1, 2016): 24–31. http://dx.doi.org/10.21859/johe-03038.

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6

Jennings, S., G. Craig, Stephan Carignan, Kris Ellis, and D. Thorndycraft Qinetiq. "Evaluating control activity as a measure of workload in flight test." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 49, no. 1 (September 2005): 64–67. http://dx.doi.org/10.1177/154193120504900115.

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This paper describes an investigation of a workload measurement technique based on pilot control movements. The Dynamic Interface Modeling and Simulation System Product Metric (DIMSS PM) assumes that pilot control activity can be used to evaluate pilot workload. Three qualified test pilots flew the fly-bywire NRC Bell 205 helicopter in a short test program that compared the DIMSS PM with subjective workload ratings and handling qualities ratings. The pilots performed a variation of an ADS-33E bob-up with varying levels of simulated turbulence and modified cyclic control characteristics. Good agreement was found for most in-flight test conditions between DIMSS Workload Metric scores and subjective workload ratings from the Bedford Workload Scale and Cooper-Harper handling qualities ratings. While, the DIMSS Workload Metric did not accurately reflect workload increases due to variations in the cyclic stick characteristics, the metric shows promise as an objective measurement tool of pilot workload in well-defined tests.
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7

Susanto, Bagus Ady, Sunardi Sunardi, and M. T. Safirin. "ANALISIS BEBAN KERJA OPERATOR PRODUKSI KORAN DENGAN METODE DEFENCE RESEARCH AGENCY WORKLOAD SCALE (DRAWS) DAN MODIFIED COOPER HARPER (MCH) DI PT.TEMPRINA MEDIA GRAFIKA GRESIK." JUMINTEN 1, no. 6 (November 16, 2020): 49–60. http://dx.doi.org/10.33005/juminten.v1i6.133.

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Temprina Media Grafika Gresik merupakan perusahaan percetakan yang bergerak di Web Rotary Offset Printing. Perusahaan mampu mencetak 30.000 eksemplar koran dengan jam kerja pukul 20.30-02.00 WIB. Tingkat tekanan kerja tinggi sering dialami operator, dikarenakan deadline cetak koran pendek dan mesin sering mengalami trouble. Selain itu, setiap tahun jumlah operator tetap. Oleh sebab itu, beban kerja merupakan hal utama yang perlu diperhatikan. Penelitian ini menggunakan metode Defence Research Agency Workload Scale (DRAWS) dan Modified Cooper Harper (MCH) dalam pengukuran beban kerja. Dengan DRAWS dapat diukur beban kerja secara umum. Lalu dianalisa lebih lanjut aktivitas (tahapan) kerja yang memiliki beban kerja tinggi dengan MCH. Berdasarkan metode DRAWS, didapat beban kerja sebesar 68,33% (kategori overload) dengan sebaran kerja fisik 44,44% dan mental 55,56%. Variabel Time Pressure mendominasi beban kerja (31,24%). Analisa lanjutan dengan metode MCH didapat bahwa dari 17 aktivitas (tahapan) kerja, 10 berkategori overload, 6 berkategori optimal load, dan 1 berkategori underload. Dari 10 aktivitas (tahapan) kerja berkategori overload (metode MCH) merupakan penyebab kerja mental dominan (sebesar 55,56%) dan berdampak pada variabel Time Presurre sehingga menyebabkan beban kerja tinggi pada operator cetak koran sebesar 68,33% (metode DRAWS). Perbaikan sistem kerja, kondisi lingkungan kerja, juga sistem maintenance dirasa perlu sebagai usulan perbaikan guna menghasilkan proses produksi yang lebih baik. Kata Kunci: Beban Kerja, DRAWS, MCH, Operator. ABSTRACT Temprina Media Grafika Gresik is a printing company engaged in Web Rotary Offset Printing. The company is able to print 30,000 copies of the newspaper with office hours at 08.30 p.m. - 02.00 a.m. The high level of work pressure is often experienced by the operator, due to the short newspaper print deadlines and the machine often experiences trouble. In addition, every year the number of operators is fixed. Therefore, workload is the main thing that needs attention. This research uses the Defense Research Agency Workload Scale (DRAWS) and Modified Cooper Harper (MCH) methods in measuring the workload of newspaper print operators. With DRAWS general workload can be measured. Then further analyzed work activities (stages) that have a high workload with MCH. Based on the DRAWS method, the value of workload is 68.33% (overload category) with the distribution of physical work 44.44% and mental work 55.56%. Time Pressure variable that dominates workload (31,24%). Further analysis using the MCH method found that out of 17 activities (stages) of work, 10 are categorized as overloads, 6 are categorized as optimal load, and 1 is categorized as underload. Of the 10 activities (stages) of work categorized as overload (MCH method) is the dominant mental work cause (55.56%) and has an impact on the Time Presurre variable, causing a high workload on the newspaper print operator of 68.33% (DRAWS method). Improvement of work systems, working environment conditions, and maintenance systems are felt necessary as a proposed improvement in order to produce a better production process. Keywords : Work load, DRAWS, MCH, Operator.
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8

Hill, Susan G., Allen L. Zaklad, Alvah C. Bittner, James C. Byers, and Richard E. Christ. "Workload Assessment of a Mobile Air Defense Missile System." Proceedings of the Human Factors Society Annual Meeting 32, no. 16 (October 1988): 1068–72. http://dx.doi.org/10.1177/154193128803201616.

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Four operator workload (OWL) scales were retrospectively applied to crewmembers of a mobile air defense missile system, LOS-F(H), following a candidate-selection field evaluation: NASA TLX, SWAT, Overall Workload (OW), and the Modified Cooper-Harper (MCH). Jackknife factor analysis revealed the presence of only a single factor (explaining 79.6% of the total variation) and indicated a significant ( p<.0075) ordering of the mean factor loadings: TLX (.935) and OW (.927) were significantly greater than MCH (.862) and SWAT(.860). Comparison with an earlier field test of a remotely piloted vehicle revealed a significant ( p<.00005) interaction of test and ordering of the OWL scales, but TLX and MCH consistently had the respectively highest and lowest loadings across the two field tests. Multiple correlation also revealed a significant ( p < .0001) relationship, R = 0.66, between system performance and TLX. These findings and lessons learned are discussed in the context of the development and validation of a methodology for assessing OWL.
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Byers, James C., Alvah C. Bittner, Susan G. Hill, Allen L. Zaklad, and Richard E. Christ. "Workload Assessment of a Remotely Piloted Vehicle (RPV) System." Proceedings of the Human Factors Society Annual Meeting 32, no. 17 (October 1988): 1145–49. http://dx.doi.org/10.1177/154193128803201704.

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Four empirical operator workload (OWL) scales were applied to ground control operations of the Aquila RPV during a recent field test: NASA TLX, SWAT, Overall Workload (OW), and the Modified Cooper-Harper (MCH). Seventeen sets of individual assessments of mission segments were made by the four members of each of four crews and one replacement crewman. Jackknife factor analysis revealed the presence of only a single factor and indicated that the mean factor loadings formed a consistent ordering ( F(3,48) = 503.5, p < .00005): TLX (.910) > SWAT (.893) > OW (.869) > MCH (.833). ANOVAs also examined the effects of various variables on the composite workload factor scores; significant findings were found which reflected both upon the system and its test. These findings as well as informal lessons learned are discussed in the context of the development and validation of a methodology for assessing OWL.
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10

Bittner, Alvah C., James C. Byers, Susan G. Hill, Allen L. Zaklad, and Richard E. Christ. "Generic Workload Ratings of a Mobile Air Defense System (LOS-F-H)." Proceedings of the Human Factors Society Annual Meeting 33, no. 20 (October 1989): 1476–80. http://dx.doi.org/10.1177/154193128903302026.

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Operator workload (OWL) scales were used to obtain ratings of generic mission scenarios and tasks for a mobile air defense missile system (LOS-F-H) following a candidate-selection field evaluation. NASA TLX, SWAT, Overall Workload (OW), and the Modified Cooper-Harper (MCH) ratings were obtained from both crew and Subject Matter Experts (SMEs). Jackknife factor analysis revealed the presence of only a single “OWL” factor for both crew and SMEs (explaining 75.9% and 82.6% of the respective total variances) and indicated a significant ( p < 0.00005) ordering of the mean factor loadings: TLX (0.924) was significantly greater than OW (0.905) and MCH (0.904), which were greater than SWAT (0.778). Subsequent analysis of OWL factor scores indicated that the crew and SMEs yielded essentially equivalent evaluations of OWL for the system variables investigated. This analysis also indicated that the highest levels of OWL were obtained for the track-to-intercept task during dual Rotary-Wing (RW) and Fixed-Wing (FW) attacks, although the ID/IFF task during a dual RW attack was almost as high. These findings are discussed in the context of a methodology for assessing OWL.
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11

Moorhouse, David J. "On the level 2 ratings of the Cooper-Harper scale." Journal of Guidance, Control, and Dynamics 13, no. 1 (January 1990): 189–91. http://dx.doi.org/10.2514/3.20535.

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12

Slongo, Artur Gustavo, Deniel Desconzi Moraes, Lorenzzo Quevedo Mantovani, and Mateus Schmitz Venturini. "Handling Qualities Analysis of an Unmanned Aircraft Vehicle for Agricultural Spraying." Journal of Aerospace Technology and Management, no. 12 (November 21, 2020): 38–51. http://dx.doi.org/10.5028/jatm.cab.1150.

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The use of unmanned aircraft vehicles (UAVs) for the most diverse aeronautic missions is a reality. Then, with the rise of precision agriculture (PA), the viability of the incorporation of this technology in the countryside on both big and small proprieties is under study. This work aims to analyze the handling qualities of an UAV with a mission of pest control chemical spraying. With this objective, aircraft data was used to analyze the eigenvalues of the aircraft modes. Then, the impact of mass and inertia variation during its mission was studied. Also, the longitudinal and latero-directional dynamics were evaluated based on the Cooper–Harper scale. The results found indicate that all aircraft modes are stable for both full hopper and empty hopper conditions. Moreover, the determined handling quality grades of the UAV in the Cooper–Harper scale indicate the need for some correction applied by the pilot during flight.
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13

Mohammed, Tariq O., Naser M. Elkhmri, and Hamza AboBakr. "Analysis and Simulation of UAV Aircraft Flight Dynamics." Advanced Materials Research 915-916 (April 2014): 7–11. http://dx.doi.org/10.4028/www.scientific.net/amr.915-916.7.

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The objective of the present work is to evaluate the static and dynamic stability of the Flying Wing Unmanned Aircraft Vehicle (UAV) model using the Tornado software. The longitudinal and the lateral-directional aerodynamics were studied using the model with incompressible flow, asymmetric, conditions. The stability coefficients were calculated and give proof that the aircraft is statically stable. Using the stability coefficients, the longitudinal and lateral-directional equations of motion were written to evaluate the dynamic stability of the vehicle. Good flying qualities were obtained, rating in Level 1 for the Cooper and Harper scale.
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14

Perfect, P., E. Timson, M. D. White, G. D. Padfield, R. Erdos, and A. W. Gubbels. "A rating scale for the subjective assessment of simulation fidelity." Aeronautical Journal 118, no. 1206 (August 2014): 953–74. http://dx.doi.org/10.1017/s0001924000009635.

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AbstractA new rating scale for capturing pilot subjective assessment of simulation fidelity is described in this paper. The scale has been developed through a series of flight and simulation trials using six test pilots from a variety of backgrounds, and is based on the methodology utilised with the Cooper-Harper Handling Qualities Rating scale and the concepts of transfer of training, comparative task performance and task strategy adaptation. The development of the new rating scale has been undertaken using simulations of rotary-wing aircraft on the University of Liverpool’s HELIFLIGHT-R research simulator, in conjunction with the Canadian Flight Research Laboratory’s Bell 412 ASRA in-flight simulator. The utility of the scale applied to locating fidelity boundaries for quantitative metrics is illustrated for an inter-axis coupling criterion. The work described in this paper is preliminary in nature, and research activities are on-going to continue the validation of the fidelity rating scale.
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Whitaker, Leslie A., Jennifer Hohne, and Deborah P. Birkmire-Peters. "Assessing Cognitive Workload Metrics for Evaluating Telecommunication Tasks." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 41, no. 1 (October 1997): 325–29. http://dx.doi.org/10.1177/107118139704100173.

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Telecommunication technology provides the potential for teamwork across distances. In this way, geographically separated team members can communicate electronically to solve problems. An experiment was conducted to test the sensitivity of three cognitive workload metrics to tasks performed under conditions of telecommunication vs. face-to-face communication. Twenty-three teams participated as subjects. A block puzzle pattern task was tested at four levels of puzzle difficulty under the two communication conditions. Task performance (time to complete and errors), as well as cognitive workload ratings were measured. Three workload metrics [Subjective Workload Assessment Technique (SWAT), NASA-TLX, and Modified Cooper Harper (MCH)] were compared. Each person's spatial ability was assessed using the Cognitive Laterality Battery. Both performance and workload varied as a function of puzzle difficulty. While all workload metrics were able to discriminate amongst some of the puzzle difficulty levels, SWAT had the two advantages of providing the most sensitive measure of difficulty plus a wider range of workload ratings.
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Stoffman, Michael R., Mark S. Roberts, and Joseph T. King. "Cervical Spondylotic Myelopathy, Depression, and Anxiety: A Cohort Analysis of 89 Patients." Neurosurgery 57, no. 2 (August 1, 2005): 307–13. http://dx.doi.org/10.1227/01.neu.0000166664.19662.43.

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ABSTRACT OBJECTIVE: To determine the prevalence of depressed and anxious mood states in patients with cervical spondylotic myelopathy (CSM), a degenerative spine condition with symptoms of neck pain, numb clumsy hands, gait difficulties, sphincter dysfunction, and impotence. To examine the relation between mood and functional deficits produced by CSM. METHODS: We surveyed a cohort of 89 patients with CSM recruited during 1 year from a neurosurgery clinic. Patients underwent a structured interview to collect information on demographics, personal habits, CSM symptoms, comorbid diseases, and symptoms of depression and anxiety. Patients self-completed the Hospital Anxiety and Depression scale and were scored on the Nurick, Cooper, Harsh, and modified Japanese Orthopaedic Association (mJOA) scales. RESULTS: According to the Hospital Anxiety and Depression scale threshold value of 11, 29% of the cohort had a depressed mood and 38% had an anxious mood. Higher depression scores were associated with worse myelopathy, as measured by the Nurick scale (P = 0.01), the Cooper leg subscale (P = 0.006), the Harsh scale (P = 0.02), the mJOA arm subscale (P = 0.006), and the mJOA leg subscale (P = 0.004). There was no relation between depression scores and the Cooper arm subscale, Harsh sphincter scale, mJOA sensory subscale, or mJOA bladder subscale. Similar patterns were seen in the relations between myelopathy and anxiety. CONCLUSION: More than one-third of patients with CSM have a depressed or anxious mood. In patients with CSM, depression and anxiety scores are strongly associated with decreased mobility, inconsistently associated with arm dysfunction, and not associated with sensory deficits or sphincter dysfunction, suggesting that ambulatory dysfunction may cause or exacerbate the symptoms of depression and anxiety in patients with CSM.
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Maldonado, Lesli Tairi Anguiano, Rogelio Uribe Poot, Diana Cristell Pérez Contreras, Armando Miranda de la Cruz, and Sergio Quiroz Gómez. "Correlación entre afrontamiento y autoestima en personas con VIH de la región de los ríos, Tabasco México." European Scientific Journal, ESJ 13, no. 18 (June 30, 2017): 140. http://dx.doi.org/10.19044/esj.2017.v13n18p140.

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Introduction: the HIV is a disease that causes important complications of health; to achieve a good confrontation and to support a levelled autoesteem are fundamental factors for his treatment. Objective: to identify the relation between the autoesteem and the confrontation in the persons with HIV of the region of Tabasco's rivers. Methodology: quantitative, descriptive study, correlacional of transverse court, n=64 participants. To measure the confrontation there was in use The Scale of Strategies modified of Coping; for the autoesteem there was in use the Scale of modified Cooper Smith. Results: 48.4 % belongs to the item of confrontation superior to the average; whereas 37.5 % presents discharge he autoestimates. The counterfoil of correlation showed a negative significant relation of the confrontation with the autoesteem rs =-.287. Conclusions: the age and the years of diagnosis are determinant for the autoesteem and the confrontation; the autoesteem and the confrontation are important for the treatment and recovery of the person with HIV / AIDS.
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Fang, Hao, Shiwei Xin, Yanlin Zhang, Zhong Wang, and Jing Zhu. "Assessing the Influence of Landmarks and Paths on the Navigational Efficiency and the Cognitive Load of Indoor Maps." ISPRS International Journal of Geo-Information 9, no. 2 (January 31, 2020): 82. http://dx.doi.org/10.3390/ijgi9020082.

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The aim of this study was to investigate whether different expressions of landmarks and paths have different influences on the navigational efficiency and the cognitive load of indoor maps. The study tested 80 subjects by indoor path discovery experiments and measured their cognitive loads with the Cooper–Harper scale. According to the results, we extracted some key landmarks from all landmarks of the experimental indoor map and evaluated the saliency degree of each path. Then, the study tested subjects with four different types of experimental indoor maps by path-recognition tasks. The results showed that maps with key landmarks are more effective in terms of navigation than those with full landmarks, but there were no significant differences between their cognitive loads. Maps with highlighted paths are more effective in terms of navigation, and their cognitive loads are much lower than those without highlighted paths. In addition, this study found that women's cognitive loads were more affected by key landmarks compared with men’s, while highlighted paths had no significant differences in terms of navigational efficiency and the cognitive load between males and females. Implications of these results with respect to the optimization strategies of indoor map designs are discussed.
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Wendt, Michal, Adrianna Banio, and Malgorzata Waszak. "IMPACT OF ACTIVE REHABILITATION ON WHEELCHAIR DISTANCE IN MEN WITH SPINAL CORD INJURY AT THE CERVICAL OR THORACIC LEVELS." Acta kinesiologica, N1 2021 (2021): 144–53. http://dx.doi.org/10.51371/issn.1840-2976.2021.15.1.18.

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The aim of the study was to evaluate the effect of Active Rehabilitation (AR) on wheelchair distance in men with spinal cord injury (SCI) at the cervical or thoracic levels. The research group consisted of 30 men with cervical or thoracic SCI. All the participants completed the "1st level" rehabilitation camp in Spała (12 days). A modified Cooper test was used twice: the day before and the day after the AR camp. AR had increased the distance covered in a wheelchair in men with thoracic (18%) and cervical (29%) SCI. The percentage of change in the Cooper test result due to AR has a statistically significant dependency on the degree of impairment of spinal cord function according to the ASIA scale (parametric test: p=0.0131, nonparametric test p=0.0018). The level of SCI does not significantly differentiate this variable (parametric test: p=0.3418, nonparametric test p=0.0673). Contrary to expectations, men with SCI at cervical level improved more, which suggests that AR is a valuable therapeutic component in the rehabilitation of patients with SCI. The wheelchair distance improvement due to AR depends more on the degree of impairment of the spinal cord function than on the level of the SCI itself.
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Mohamed, Mohamed Abd-El-Hakeem, Ziad M. Ali, Mahrous Ahmed, and Saad F. Al-Gahtani. "Energy Saving Maximization of Balanced and Unbalanced Distribution Power Systems via Network Reconfiguration and Optimum Capacitor Allocation Using a Hybrid Metaheuristic Algorithm." Energies 14, no. 11 (May 30, 2021): 3205. http://dx.doi.org/10.3390/en14113205.

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The main aim of this work was the maximization of the energy saving of balanced and unbalanced distribution power systems via system reconfiguration and the optimum capacitor’s bank choice, which were estimated by using a new algorithm: modified Tabu search and Harper sphere search (MTS-HSSA). The results demonstrated that the proposed method is appropriate for energy saving and improving performance compared with other methods reported in the literature for IEEE 33-bus adopted systems, including large scale systems such as IEEE 119 and the IEEE 123 unbalanced distribution system. Moreover, it can be used for unbalanced distribution systems distributed generators (DGs). The results demonstrated that the proposed method (the optimal choice of shunt capacitor (SC) banks and the optimal reconfiguration via the proposed algorithm) is appropriate for energy saving compared with different strategies for energy saving, which included distributed generation (DG) at different cost levels.
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Vleggeert-Lankamp, Carmen, and Wilco Peul. "Surgical decompression of thoracic spinal stenosis in achondroplasia: indication and outcome." Journal of Neurosurgery: Spine 17, no. 2 (August 2012): 164–72. http://dx.doi.org/10.3171/2012.4.spine1220.

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Object The achondroplastic spinal canal is narrow due to short pedicles and a small interpedicular distance. Compression of neural structures passing through this canal is therefore regularly encountered but rarely described. Symptomatology, radiological evaluation, and treatment of 20 patients with achondroplasia who underwent decompression of the thoracic spinal cord are described and outcome is correlated with the size of the spinal canal and the thoracolumbar kyphotic angle. Methods Scores from the modified Japanese Orthopaedic Association scale, Nurick scale, European Myelopathy scale, Cooper myelopathy scale for lower extremities, and Odom criteria before and after surgery were compared. Magnetic resonance imaging was evaluated to determine the size of the spinal canal, spinal cord compression, and presence of myelomalacia. The thoracolumbar kyphotic angle was measured using fluoroscopy. Results Patient symptomatology included deterioration of walking pattern, pain, cramps, spasms, and incontinence. Magnetic resonance images of all patients demonstrated spinal cord compression due to degenerative changes. Surgery resulted in a slight improvement on all the ranking scales. Surgery at the wrong level occurred in 15% of cases, but no serious complications occurred. The mean thoracolumbar kyphotic angle was 20°, and no correlation was established between this angle and outcome after surgery. No postoperative increase in this angle was reported. There was also no correlation between size of the spinal canal and outcome. Conclusions Decompressive surgery of the thoracic spinal cord in patients with achondroplasia can be performed safely if anatomical details are taken into consideration. Spondylodesis did not appear essential. Special attention should be given to the method of surgery, identification of the level of interest, and follow-up of the thoracolumbar kyphotic angle.
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Houten, John K., and Paul R. Cooper. "Laminectomy and Posterior Cervical Plating for Multilevel Cervical Spondylotic Myelopathy and Ossification of the Posterior Longitudinal Ligament: Effects on Cervical Alignment, Spinal Cord Compression, and Neurological Outcome." Neurosurgery 52, no. 5 (May 1, 2003): 1081–88. http://dx.doi.org/10.1093/neurosurgery/52.5.1081.

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Abstract OBJECTIVE Multilevel anterior decompressive procedures for cervical spondylotic myelopathy or ossification of the posterior longitudinal ligament may be associated with a high incidence of neurological morbidity, construct failure, and pseudoarthrosis. We theorized that laminectomy and stabilization of the cervical spine with lateral mass plates would obviate the disadvantages of anterior decompression, prevent the development of kyphotic deformity frequently seen after uninstrumented laminectomy, decompress the spinal cord, and produce neurological results equal or superior to those achieved by multilevel anterior procedures. METHODS We retrospectively reviewed the records of 38 patients who underwent laminectomy and lateral mass plating for cervical spondylotic myelopathy or ossification of the posterior longitudinal ligament between January 1994 and November 2001. Seventy-six percent of patients had spondylosis, 18% had ossification of the posterior longitudinal ligament, and 5% had both. Clinical presentation included upper extremity sensory complaints (89%), gait difficulty (70%), and hand use deterioration (67%). Spasticity was present in 83%, and weakness of one or more muscle groups was seen in 79%. Spinal cord signal abnormality on sagittal T2-weighted magnetic resonance imaging (MRI) was seen in 68%. Neurological evaluation was performed using a modification of the Japanese Orthopedic Association Scale for functional assessment of myelopathy, the Cooper Scale for separate evaluation of upper and lower extremity motor function, and a five-point scale for evaluation of strength in individual muscle groups. Lateral cervical spine x-rays were analyzed using a curvature index to determine maintenance of alignment. Each surgically decompressed level was graded on a four-point scale using axial MRI to assess the adequacy of decompression. Late follow-up was conducted by telephone interview. RESULTS Laminectomy was performed at a mean 4.6 levels. Follow-up was obtained at a mean of 30.2 months after the procedure. The score on the modified Japanese Orthopedic Association scale improved in 97% of patients from a mean of 12.9 preoperatively to 15.58 postoperatively (P&lt; 0.0001). In the upper extremities, function measured by the Cooper Scale improved from 1.8 to 0.7 (P&lt; 0.0001), and in the lower extremities, function improved from 1.0 to 0.4 (P&lt; 0.0002). There was a statistically significant improvement in strength in the triceps (P&lt; 0.0001), iliopsoas (P&lt; 0.0002), and hand intrinsic muscles (P&lt; 0.0001). X-rays obtained at a mean of 5.9 months after surgery revealed no change in spinal alignment as measured by the curvature index. There was a decrease in the mean preoperative compression grade from 2.46 preoperatively to 0.16 postoperatively (P&lt; 0.0001). There was no correlation between neurological outcome and the presence of spinal cord signal change on T2-weighted MRI scans, patient age, duration of symptoms, or preoperative medical comorbidity. CONCLUSION Multilevel laminectomy and instrumentation with lateral mass plates is associated with minimal morbidity, provides excellent decompression of the spinal cord (as visualized on MRI), produces immediate stability of the cervical spine, prevents kyphotic deformity, and precludes further development of spondylosis at fused levels. Neurological outcome is equal or superior to multilevel anterior procedures and prevents spinal deformity associated with laminoplasty or noninstrumented laminectomy.
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23

Magnani, Chiara F., Claudia Mezzanotte, Claudia Cappuzzello, Fabrizio Benedicenti, Michela Bardini, Sarah Tettamanti, Grazia Fazio, et al. "Sleeping Beauty Modified CAR+ Lymphocytes Engraft and Exhibit Anti-Tumor Activity in Patient-Derived Xenograft Models of Acute Lymphoblastic Leukemia." Blood 128, no. 22 (December 2, 2016): 4022. http://dx.doi.org/10.1182/blood.v128.22.4022.4022.

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Abstract Background: Adoptive infusion of T lymphocytes modified with anti-CD19 chimeric antigen receptor (CAR) by viral vectors is a therapeutic option proven effective in the treatment of hematological malignancies. In the context of B-lineage neoplasms, CD19-specific CART cells demonstrated unexpected positive results, achieving complete remission and durable response. To overcome high manufacturing costs, regulatory hurdles and scale-up complexities, we recently established a platform for non-viral gene manipulation of Cytokine-Induced Killer (CIK) cells, an effector T cell population characterized by enrichment in highly cytotoxic CD3+CD56+ cells and reduced risk of GvHD, in compliance with Good manufacturing practices (GMP). Therefore, we investigate whether donor-derived CD19CAR redirected CIK cells can significantly increase anti-leukemic responses in Acute Lymphoblastic Leukemia (ALL) by performing a pre-clinical validation of the non-viral platform. Methods: Large-scale production will be performed by nucleofection in presence of two GMP-grade Sleeping Beauty transposon DNA plasmids, coding for the anti-CD19CD28OX40 CAR transgene and for the SB11 transposase. T cells were differentiated according to a procedure derived from the Eudract n 2008-003185-26 study with the addition of a single stimulation with gamma-irradiated PBMCs to rescue the impaired T-cell expansion induced by electroporation. Results: The feasibility of large scale manufacturing process was verified starting from 30-60X10^6 PBMC, reaching efficient expansion with an average of 69.3±15.2-fold increase (Figure 1A) and stable expression of CD19CAR (average 65%, Figure 1B). Immunophenotypic analysis showed the typical enrichment of the CD3+/CD56+ cell subset, and maintenance of naive and central memory CD8+ and CD4+ T cells. Modified cells displayed a specific and effective cytotoxicity and proliferation towards CD19+ cell lines and primary tumors. In order to determine the biological effect of CARCIK-CD19 cells on disease and the correct dose for optimal activity, we performed a CARCIK-cell dose titration in a xenograft mouse model of common BCP-ALL, bearing the feature of a Ph-like gene rearrangement (PAX5/AUTS2). Mice were treated with 5x106, 10x106, 15x106 CAR+ cells or with 10x106 not transduced (NT) cells. CARCIK-CD19 cells showed a dose-dependent antitumor response and persisted in tumor-bearing animals, in peripheral blood (PB), bone marrow (BM) and spleen (Figure 2). Furthermore, to evaluate whether cryopreservation affects the activity of the cell product, we performed functional experiments with both fresh and frozen/thawed CAR CIK cells in vitro and in an established MLL/ENL patient-derived xenograft model. CARCIK.CD19 cells remained functional after freezing and thawing as evidenced by killing activity and decreased level of leukemic engraftment in the spleen of treated mice. Finally, we evaluated CARCIK-CD19 cell bio-distribution, safety and acute toxicity in NOD-SCID-gamma chain-/- (NSG) mice. The infusion of CARCIK-CD19 cells proved to be safe and well tolerated in all mice tested. The infused cells persisted in time in the hematopoietic and post-injection perfused organs with a follow-up of 3 months. Conclusions: Our findings describe a novel donor-derived non-viral CAR approach characterized by efficient cell transfection, expansion and functionality that could be used as valid and sustainable alternative to patient-derived viral approach with the aim to increase the cure rate of children and adults with leukemia. This study provides the proof-of-concept for designing phase I/II study for relapsing and refractory ALL post Hematopoietic Stem Cell Transplantation. Disclosures Cooper: Ziopharm Oncology: Employment, Equity Ownership, Patents & Royalties; Intrexon: Equity Ownership; City of Hope: Patents & Royalties; Targazyme, Inc.,: Equity Ownership; Immatics: Equity Ownership; Sangamo BioSciences: Patents & Royalties; MD Anderson Cancer Center: Employment; Miltenyi Biotec: Honoraria. Biondi:Cellgene: Other: Advisory Board; Novartis: Membership on an entity's Board of Directors or advisory committees, Other: Advisory Board; BMS: Membership on an entity's Board of Directors or advisory committees.
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24

Allgulander, Christer, Orlando Alonso Betancourt, David Blackbeard, Helen Clark, Franco Colin, Sarah Cooper, Robin Emsley, et al. "16th National Congress of the South African Society of Psychiatrists (SASOP)." South African Journal of Psychiatry 16, no. 3 (October 1, 2010): 29. http://dx.doi.org/10.4102/sajpsychiatry.v16i3.273.

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<p><strong>List of abstracts and authors:</strong></p><p><strong>1. Antipsychotics in anxiety disorders</strong></p><p>Christer Allgulander</p><p><strong>2. Anxiety in somatic disorders</strong></p><p>Christer Allgulander</p><p><strong>3. Community rehabilitation of the schizophrenic patient</strong></p><p>Orlando Alonso Betancourt, Maricela Morales Herrera</p><p><strong>4. Dual diagnosis: A theory-driven multidisciplinary approach for integrative care</strong></p><p>David Blackbeard</p><p><strong>5. The emotional language of the gut - when 'psyche' meets 'soma'</strong></p><p>Helen Clark</p><p><strong>6. The Psychotherapy of bipolar disorder</strong></p><p>Franco Colin</p><p><strong>7. The Psychotherapy of bipolar disorder</strong></p><p>Franco Colin</p><p><strong>8. Developing and adopting mental health policies and plans in Africa: Lessons from South Africa, Uganda and Zambia</strong></p><p>Sara Cooper, Sharon Kleintjes, Cynthia Isaacs, Fred Kigozi, Sheila Ndyanabangi, Augustus Kapungwe, John Mayeya, Michelle Funk, Natalie Drew, Crick Lund</p><p><strong>9. The importance of relapse prevention in schizophrenia</strong></p><p>Robin Emsley</p><p><strong>10. Mental Health care act: Fact or fiction?</strong></p><p>Helmut Erlacher, M Nagdee</p><p><strong>11. Does a dedicated 72-hour observation facility in a district hospital reduce the need for involuntary admissions to a psychiatric hospital?</strong></p><p>Lennart Eriksson</p><p><strong>12. The incidence and risk factors for dementia in the Ibadan study of ageing</strong></p><p>Oye Gureje, Lola Kola, Adesola Ogunniyi, Taiwo Abiona</p><p><strong>13. Is depression a disease of inflammation?</strong></p><p><strong></strong>Angelos Halaris</p><p><strong>14. Paediatric bipolar disorder: More heat than light?</strong></p><p>Sue Hawkridge</p><p><strong>15. EBM: Anova Conundrum</strong></p><p>Elizabeth L (Hoepie) Howell</p><p><strong>16. Tracking the legal status of a cohort of inpatients on discharge from a 72-hour assessment unit</strong></p><p>Bernard Janse van Rensburg</p><p><strong>17. Dual diagnosis units in psychiatric facilities: Opportunities and challenges</strong></p><p>Yasmien Jeenah</p><p><strong>18. Alcohol-induced psychotic disorder: A comparative study on the clinical characteristics of patients with alcohol dependence and schizophrenia</strong></p><p>Gerhard Jordaan, D G Nel, R Hewlett, R Emsley</p><p><strong>19. Anxiety disorders: the first evidence for a role in preventive psychiatry</strong></p><p>Andre F Joubert</p><p><strong>20. The end of risk assessment and the beginning of start</strong></p><p>Sean Kaliski</p><p><strong>21. Psychiatric disorders abd psychosocial correlates of high HIV risk sexual behaviour in war-effected Eatern Uganda</strong></p><p>E Kinyada, H A Weiss, M Mungherera, P Onyango Mangen, E Ngabirano, R Kajungu, J Kagugube, W Muhwezi, J Muron, V Patel</p><p><strong>22. One year of Forensic Psychiatric assessment in the Northern Cape: A comparison with an established assessment service in the Eastern Cape</strong></p><p>N K Kirimi, C Visser</p><p><strong>23. Mental Health service user priorities for service delivery in South Africa</strong></p><p>Sharon Kleintjes, Crick Lund, Leslie Swartz, Alan Flisher and MHaPP Research Programme Consortium</p><p><strong>24. The nature and extent of over-the-counter and prescription drug abuse in cape town</strong></p><p>Liezl Kramer</p><p><strong>25. Physical health issues in long-term psychiatric inpatients: An audit of nursing statistics and clinical files at Weskoppies Hospital</strong></p><p>Christa Kruger</p><p><strong>26. Suicide risk in Schizophrenia - 20 Years later, a cohort study</strong></p><p>Gian Lippi, Ean Smit, Joyce Jordaan, Louw Roos</p><p><strong>27.Developing mental health information systems in South Africa: Lessons from pilot projects in Northern Cape and KwaZulu-Natal</strong></p><p>Crick Lund, S Skeen, N Mapena, C Isaacs, T Mirozev and the Mental Health and Poverty Research Programme Consortium Institution</p><p><strong>28. Mental health aspects of South African emigration</strong></p><p>Maria Marchetti-Mercer</p><p><strong>29. What services SADAG can offer your patients</strong></p><p>Elizabeth Matare</p><p><strong>30. Culture and language in psychiatry</strong></p><p>Dan Mkize</p><p><strong>31. Latest psychotic episode</strong></p><p>Povl Munk-Jorgensen</p><p><strong>32. The Forensic profile of female offenders</strong></p><p>Mo Nagdee, Helmut Fletcher</p><p><strong>33. The intra-personal emotional impact of practising psychiatry</strong></p><p>Margaret Nair</p><p><strong>34. Highly sensitive persons (HSPs) and implications for treatment</strong></p><p>Margaret Nair</p><p><strong>35. Task shifting in mental health - The Kenyan experience</strong></p><p>David M Ndetei</p><p><strong>36. Bridging the gap between traditional healers and mental health in todya's modern psychiatry</strong></p><p>David M Ndetei</p><p><strong>37. Integrating to achieve modern psychiatry</strong></p><p>David M Ndetei</p><p><strong>38. Non-medical prescribing: Outcomes from a pharmacist-led post-traumatic stress disorder clinic</strong></p><p>A Parkinson</p><p><strong>39. Is there a causal relationship between alcohol and HIV? Implications for policy, practice and future research</strong></p><p>Charles Parry</p><p><strong>40. Global mental health - A new global health discipline comes of age</strong></p><p>Vikram Patel</p><p><strong>41. Integrating mental health into primary health care: Lessons from pilot District demonstration sites in Uganda and South Africa</strong></p><p>Inge Petersen, Arvin Bhana, K Baillie and MhaPP Research Programme Consortium</p><p><strong>42. Personality disorders -The orphan child in axis I - Axis II Dichotomy</strong></p><p><strong></strong>Willie Pienaar</p><p><strong>43. Case Studies in Psychiatric Ethics</strong></p><p>Willie Pienaar</p><p><strong>44. Coronary artery disease and depression: Insights into pathogenesis and clinical implications</strong></p><p>Janus Pretorius</p><p><strong>45. Impact of the Mental Health Care Act No. 17 of 2002 on designated hospitals in KwaZulu-Natal: Triumphs and trials</strong></p><p>Suvira Ramlall, Jennifer Chipps</p><p><strong>46. Biological basis of addication</strong></p><p>Solomon Rataemane</p><p><strong>47. Genetics of Schizophrenia</strong></p><p>Louw Roos</p><p><strong>48. Management of delirium - Recent advances</strong></p><p>Shaquir Salduker</p><p><strong>49. Social neuroscience: Brain research on social issues</strong></p><p>Manfred Spitzer</p><p><strong>50. Experiments on the unconscious</strong></p><p>Manfred Spitzer</p><p><strong>51. The Psychology and neuroscience of music</strong></p><p>Manfred Spitzer</p><p><strong>52. Mental disorders in DSM-V</strong></p><p>Dan Stein</p><p><strong>53. Personality, trauma exposure, PTSD and depression in a cohort of SA Metro policemen: A longitudinal study</strong></p><p>Ugashvaree Subramaney</p><p><strong>54. Eating disorders: An African perspective</strong></p><p>Christopher Szabo</p><p><strong>55. An evaluation of the WHO African Regional strategy for mental health 2001-2010</strong></p><p>Thandi van Heyningen, M Majavu, C Lund</p><p><strong>56. A unitary model for the motor origin of bipolar mood disorders and schizophrenia</strong></p><p>Jacques J M van Hoof</p><p><strong>57. The origin of mentalisation and the treatment of personality disorders</strong></p><p>Jacques J M Hoof</p><p><strong>58. How to account practically for 'The Cause' in psychiatric diagnostic classification</strong></p><p>C W (Werdie) van Staden</p><p><strong>POSTER PRESENTATIONS</strong></p><p><strong>59. Problem drinking and physical and sexual abuse at WSU Faculty of Health Sciences, Mthatha, 2009</strong></p><p>Orlando Alonso Betancourt, Maricela Morales Herrera, E, N Kwizera, J L Bernal Munoz</p><p><strong>60. Prevalence of alcohol drinking problems and other substances at WSU Faculty of Health Sciences, Mthatha, 2009</strong></p><p>Orlando Alonso Betancourt, Maricela Morales Herrera, E, N Kwizera, J L Bernal Munoz</p><p><strong>61. Lessons learnt from a modified assertive community-based treatment programme in a developing country</strong></p><p>Ulla Botha, Liezl Koen, John Joska, Linda Hering, Piet Ooosthuizen</p><p><strong>62. Perceptions of psychologists regarding the use of religion and spirituality in therapy</strong></p><p>Ottilia Brown, Diane Elkonin</p><p><strong>63. Resilience in families where a member is living with schizophreni</strong></p><p>Ottilia Brown, Jason Haddad, Greg Howcroft</p><p><strong>64. Fusion and grandiosity - The mastersonian approach to the narcissistic disorder of the self</strong></p><p>William Griffiths, D Macklin, Loray Daws</p><p><strong>65. Not being allowed to exist - The mastersonian approach to the Schizoid disorder of the self</strong></p><p>William Griffiths, D Macklin, Loray Daws</p><p><strong>66. Risky drug-injecting behaviours in Cape Town and the need for a needle exchange programme</strong></p><p>Volker Hitzeroth</p><p><strong>67. Neuroleptic malignant syndrome in adolescents in the Western Cape: A case series</strong></p><p>Terri Henderson</p><p><strong>68. Experience and view of local academic psychiatrists on the role of spirituality in South African specialist psychiatry, compared with a qualitative analysis of the medical literature</strong></p><p>Bernard Janse van Rensburg</p><p><strong>69. The role of defined spirituality in local specialist psychiatric practice and training: A model and operational guidelines for South African clinical care scenarios</strong></p><p>Bernard Janse van Rensburg</p><p><strong>70. Handedness in schizophrenia and schizoaffective disorder in an Afrikaner founder population</strong></p><p>Marinda Joubert, J L Roos, J Jordaan</p><p><strong>71. A role for structural equation modelling in subtyping schizophrenia in an African population</strong></p><p>Liezl Koen, Dana Niehaus, Esme Jordaan, Robin Emsley</p><p><strong>72. Caregivers of disabled elderly persons in Nigeria</strong></p><p>Lola Kola, Oye Gureje, Adesola Ogunniyi, Dapo Olley</p><p><strong>73. HIV Seropositivity in recently admitted and long-term psychiatric inpatients: Prevalence and diagnostic profile</strong></p><p>Christina Kruger, M P Henning, L Fletcher</p><p><strong>74. Syphilis seropisitivity in recently admitted longterm psychiatry inpatients: Prevalence and diagnostic profile</strong></p><p>Christina Kruger, M P Henning, L Fletcher</p><p><strong>75. 'The Great Suppression'</strong></p><p>Sarah Lamont, Joel Shapiro, Thandi Groves, Lindsey Bowes</p><p><strong>76. Not being allowed to grow up - The Mastersonian approach to the borderline personality</strong></p><p>Daleen Macklin, W Griffiths</p><p><strong>77. Exploring the internal confirguration of the cycloid personality: A Rorschach comprehensive system study</strong></p><p>Daleen Macklin, Loray Daws, M Aronstam</p><p><strong>78. A survey to determine the level of HIV related knowledge among adult psychiatric patients admitted to Weskoppies Hospital</strong></p><p><strong></strong> T G Magagula, M M Mamabolo, C Kruger, L Fletcher</p><p><strong>79. A survey of risk behaviour for contracting HIV among adult psychiatric patients admitted to Weskoppies Hospital</strong></p><p>M M Mamabolo, T G Magagula, C Kruger, L Fletcher</p><p><strong>80. A retrospective review of state sector outpatients (Tara Hospital) prescribed Olanzapine: Adherence to metabolic and cardiovascular screening and monitoring guidelines</strong></p><p>Carina Marsay, C P Szabo</p><p><strong>81. Reported rapes at a hospital rape centre: Demographic and clinical profiles</strong></p><p>Lindi Martin, Kees Lammers, Donavan Andrews, Soraya Seedat</p><p><strong>82. Exit examination in Final-Year medical students: Measurement validity of oral examinations in psychiatry</strong></p><p>Mpogisheng Mashile, D J H Niehaus, L Koen, E Jordaan</p><p><strong>83. Trends of suicide in the Transkei region of South Africa</strong></p><p>Banwari Meel</p><p><strong>84. Functional neuro-imaging in survivors of torture</strong></p><p>Thriya Ramasar, U Subramaney, M D T H W Vangu, N S Perumal</p><p><strong>85. Newly diagnosed HIV+ in South Africa: Do men and women enroll in care?</strong></p><p>Dinesh Singh, S Hoffman, E A Kelvin, K Blanchard, N Lince, J E Mantell, G Ramjee, T M Exner</p><p><strong>86. Diagnostic utitlity of the International HIC Dementia scale for Asymptomatic HIV-Associated neurocognitive impairment and HIV-Associated neurocognitive disorder in South Africa</strong></p><p>Dinesh Singh, K Goodkin, D J Hardy, E Lopez, G Morales</p><p><strong>87. The Psychological sequelae of first trimester termination of pregnancy (TOP): The impact of resilience</strong></p><p>Ugashvaree Subramaney</p><p><strong>88. Drugs and other therapies under investigation for PTSD: An international database</strong></p><p>Sharain Suliman, Soraya Seedat</p><p><strong>89. Frequency and correlates of HIV Testing in patients with severe mental illness</strong></p><p>Hendrik Temmingh, Leanne Parasram, John Joska, Tania Timmermans, Pete Milligan, Helen van der Plas, Henk Temmingh</p><p><strong>90. A proposed mental health service and personnel organogram for the Elizabeth Donkin psychiatric Hospital</strong></p><p>Stephan van Wyk, Zukiswa Zingela</p><p><strong>91. A brief report on the current state of mental health care services in the Eastern Cape</strong></p><p>Stephan van Wyk, Zukiswa Zingela, Kiran Sukeri, Heloise Uys, Mo Nagdee, Maricela Morales, Helmut Erlacher, Orlando Alonso</p><p><strong>92. An integrated mental health care service model for the Nelson Mandela Bay Metro</strong></p><p>Stephan van Wyk, Zukiswa Zingela, Kiran Sukeri</p><p><strong>93. Traditional and alternative healers: Prevalence of use in psychiatric patients</strong></p><p>Zukiswa Zingela, S van Wyk, W Esterhuysen, E Carr, L Gaauche</p>
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25

Ivler, Christina M., Kevin Truong, Declan Kerwin, Joel Otomize, Danielle Parmer, Mark B. Tischler, and Norma Gowans. "Development and Flight Validation of Proposed Unmanned Aerial System Handling Qualities Requirements." Journal of the American Helicopter Society, 2021. http://dx.doi.org/10.4050/jahs.67.012002.

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Unmanned aerial systems, commonly known as drones, present new opportunities to perform autonomous tasks. Handling qualities requirements for manned vertical lift aircraft have been well defined and documented. The need to define handling qualities requirements for vertical take-off and landing (VTOL) unmanned aerial systems (UAS) to meet mission demands is of paramount importance for all potential operators and procurement agencies. One way to relate handling qualities specifications of large-scale manned and subscale unmanned aircraft is through Froude dynamic scaling. Froude dynamic scaling based on hub-to-hub distance has shown great promise in relating the natural frequencies of scaled multicopters. There have been recent efforts to develop a VTOL-UAS handling qualities standard by scaling mission task elements and rating their performance through a Trajectory, Tracking, and Aggression (TTA) score. This paper proposes a new performance standard adapted from the TTA scoring method, along with a modified Cooper–Harper scale as a VTOL-UAS handling qualities framework that is consistent with the spirit of Aeronautical Design Standard 33 (ADS-33). These newly proposed performance standards were then validated through simulation and flight testing on a small hexacopter UAS, flown at the University of Portland. A key outcome of this work is the flight verification of a key dynamic response metric, the disturbance rejection bandwidth, and associated validation of Froude scaling for predicted handling qualities metrics.
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26

Gehrmann, Richard. "War, Snipers, and Rage from Enemy at the Gates to American Sniper." M/C Journal 22, no. 1 (March 13, 2019). http://dx.doi.org/10.5204/mcj.1506.

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The concept of war is inextricably linked to violence, and military action almost always resounds with the emotion and language of rage. Since the War on Terror began in September 2001, post-9/11 expressions of terror and rage have influenced academics to evaluate rage and its meanings (Gildersleeve and Gehrmann). Of course, it has directly influenced the lives of those affected by global conflicts in war-torn regions of the Middle East and North Africa. The populace there has reacted violently to military invasions with a deep sense of rage, while in the affluent West, rage has also infiltrated everyday life through clothes, haircuts, and popular culture as military chic became ‘all the rage’ (Rall 177). Likewise, post-9/11 popular films directly tap into rage and violence to explain (or justify?) conflict and war. The film version of the life of United States Iraq veteran Chris Kyle in American Sniper (2014) reveals fascinating depictions of rage through the perspective of a highly trained shooter who waits patiently above the battlefield, watching for hours before taking human life with a carefully planned long-distance shot. The significance of the complexities of rage as presented in this film are discussed later. Foundations of Rage: Colonial Legacy, Arab Spring, and ISISThe War on Terror may have purportedly began with the rage of Osama bin Laden’s Al Qaeda missions and the responding rage of George Bush’s America determined to seek vengeance for 9/11, but the rage simmering in the Middle East has deeper origins. This includes: the rejection of the Shah of Iran's secular dictatorship in 1979, the ongoing trauma of an Arab Palestinian state that was promised in 1947, and the blighted hopes of Gamal Abdel Nasser's Arab nationalism that offered so much in the 1950s but failed to deliver. But these events should not be considered in isolation from events of the whole 20th century, in particular the betrayal of Arab nationalism by the Allied forces, especially Britain and France after the First World War. The history of injustice that Robert Fisk has chronicled in a monumental volume reveals the complexity and nuances of an East-West conflict that continued to fracture the Middle East. In a Hollywood-based film such as American Sniper it is easy to depict the region from a Western perspective without considering the cycle of injustice and oppression that gave birth to the rage that eventually lashed out at the West. Rage can also be rage against war, or rage about the mistreatment of war victims. The large-scale protests against the war before the 2003 Iraq invasion have faded into apparent nothingness, despite nearly two decades of war. Protest rage appears to have been replaced by outrage on behalf of the victims of war; the refugees, asylum seekers, economic migrants and those displaced by the ever- spreading conflict that received a new impetus in 2011 with the Arab Spring democracy movements. One spark point for rage ignited when Tunisian street vendor Mohamed Bouazizi embarked on his act of self-immolation in protest against harassment by public officials. This moment escalated into a kaleidoscope of collective rage as regimes were challenged from Syria to Libya, but met with a tragic aftermath. Sadly, democratic governments did not emerge, but turned into regimes of extremist violence exemplified in the mediaeval misogynistic horror now known as ISIS, or IS, or the Islamic State of Iraq and Syria (Hassan). This horror intensified as millions of civilised Syrians and Iraqis sought to flee their homelands. The result was the movement of peoples, which included manipulation by ruthless people smugglers and detention by governments determined to secure borders — even even as this eroded decades of consensus on the rights of refugees. One central image, that of three-year-old Aylan Kurdi’s corpse washed up on a beach (Smith) should invoke open rage. Here, the incongruity was that a one-time Turkish party beach for affluent 18 to 35-year-olds from Western Europe would signify the death place of a Syrian refugee child, now displaced by war. The historical significance of East/West conflicts in the Middle East, recent events post- Arab Spring, the resulting refugee crisis in the region, and global anti-war protests should be foremost when examining Clint Eastwood's film about an American military sniper in Iraq.Hot Rage and Cold Rage Recent mass shootings in the United States have delineated factions within the power of rage: it seems to blow either hot or cold. US Army psychiatrist Major Nidal Malik Hasan was initially calm when he embarked on a public expression of rage, wounding 30 people and murdering 13 others in a mass shooting event in 2009 (MacAskill). Was this to be categorised as the rage of a nihilist, an Islamist - or as just another American mass shooting like events in Orlando or Sandy Hook? The war journalist and film maker Sebastian Junger authored a study on belonging, where he linked mass shootings (or rampage killings) to social stress and disunity, as a “tendency rising steadily in the US since the 1980s” (115-116). In contrast, the actions of a calm and isolated shooter on a rooftop can be justified as acceptable behaviour if this occurs during war. Now in the case of Chris Kyle, he normalised his tale of calm killing, as an example identified by action “built on a radically asymmetric violence” (Pomarede 53).Enemy at the Gates The point is that sniper killings can be presented in film as morally good. For example, the 2001 film Enemy at the Gates portrays a duel of two snipers in Stalingrad, Russia. This is a fictionalised contest of a fictionalised event, because there was only tangential evidence that Russian sniper hero Vasily Zaytsev actually engaged in a three-day sniper duel with his German enemy during the Second World War. Enemy at the Gates presents the sniper as an acceptable figure in mass popular culture (or even a hero?), which provides the justification for American Sniper. However, in this instance, viewers could recognise a clear struggle between good and evil.Politically, Enemy at the Gates, whether viewed from a conservative or a progressive perspective, presents a struggle between a soldier of the allies (the Soviet Union) and the forces of Nazism, undeniably the most evil variant of fascism. We can interpret this as a defence of the communist heartland, or the defence of a Russian motherland, or the halting of Nazi aggression at its furthest expansion point. Whichever way it is viewed, the Russian sniper is a good man, and although in the movie’s plot the actor Ralph Fiennes as political commissar injects a dimension of manipulation and Stalinist authoritarian control, this does not detract from the idea of the hero defeating evil with single aimed shots. There is rage, but it is overshadowed by the moral ‘good.’American Sniper The true story of Chris Kyle is quite simple. A young man grows up in Texas with ‘traditional’ American values, tries sport and University, tries ranch life, and joins the US Navy Special Forces. He becomes a SEAL (Sea, Air and Land) team member, and is trained as a specialist sniper. Kyle excels as a sniper in Iraq, where he self-identifies as America's most successful sniper. He kills a lot of enemies in Iraq, experiences multiple deployments followed by the associated trauma of reintegration to family life and redeployment, suffers from PTSD, returns to civilian life in America and is himself shot dead by a distressed veteran, in an ironic act of rage. Admired by many, the veracity of Kyle’s story is challenged by others, a point I will return to. As noted above, Kyle kills a lot of people, many of whom are often unaware of his existence. In his book On Killing, Lieutenant-Colonel David Grossman notes this a factor that actually causes the military to have a “degree of revulsion towards snipers” (109), which is perhaps why the movie version of Kyle’s life promotes a rehabilitation of the military in its “unambiguous advocacy of the humility, dedication, mastery, and altruism of the sniper” as hero (Beck 218). Most enlisted soldiers never actually kill their enemies, but Kyle kills well over 100 while on duty.The 2012 book memoir of United States Navy sniper Chris Kyle at war in Iraq became a national cultural artefact. The film followed in 2014, allowing the public dramatisation of this to offer a more palatable form for a wider audience. It is noted that military culture at the national level is malleable and nebulous (Black 42), and these constructs are reflected in the different variants of American Sniper. These cultural products are absorbed differently when consumed by the culture that has produced them (the military), as compared to the way that they are consumed by the general public, and the book American Sniper reflects this. Depending upon readers’ perspectives, it is a book of raw honesty or nationalistic jingoism, or perhaps both. The ordinary soldier’s point of view is reiterated and directed towards a specifically American audience. Despite controversy and criticism the book was immensely successful, with weeks on the New York Times bestseller list. While it naturally appealed to many in its primary American audience, from an Australian perspective, the jingoism of this book jars. In fact, it really jars a lot, to the point of being quite challenging to read. That Australian readers would have difficulty with this text is probably appropriate, because after all, the book was not created for Australians but for Americans.On the other hand, Americans have produced balanced accounts of the soldier experience in Iraq. A very different exemplar is Garry Trudeau’s Doonesbury blog that became the book The Sandbox (2007). Here American men and women soldiers wrote their own very revealing stories about the wars in Iraq and Afghanistan, in autobiographical accounts that ranged from nuanced explanations of the empathy for the soldier’s predicament, to simple outright patriotism. TIn their first-hand accounts of war showed a balance of ordinary pathos, humour – and the raw brutality of a soldier finding the neck stem of a human spine on the ground after a suicide bomb attack (Trudeau 161) – and even this seems more palatable to read than American Sniper. A similar book on the US military sniper experience (Cavallaro and Larsen) also shows it is possible to incorporate a variety of perspectives without patriotic jingoism, or even military propaganda being predominant.In contrast to the book, the film American Sniper narrates a more muted story. The movie is far more “saccharine”, in the words of critical Rolling Stone reviewer Matt Taibbi, but still reflects a nationalistic attitude to war and violence — appropriate to the mood of the book. American producer/director Clint Eastwood has developed his own style for skipping around the liminal space that exists between thought-provoking analysis and populism, and American Sniper is no exception. The love story of Chris Kyle and his wife Taya looks believable, and the intensity of military training and war fighting, including the dispassionate thoughts of Kyle as sniper, are far more palatable in the film version than as the raw words on the page.The Iraq War impacted on millions of Americans, and it is the compelling images shown re-living Chris Kyle’s funeral at the film’s conclusion that leaves a lasting message. The one-time footballer’s memorial service is conducted in a Texas football stadium and this in itself is poignant: but it is the thousands of people who lined the highway overpasses for over 200 miles to farewell him and show respect as his body travels towards the funeral in the stadium, that gives us an insight into the level of disenchantment and rage at America’s loss. This is a rage fuelled by losing their military ‘empire’ coupled with a traumatised search for meaning that Jerry Lembcke sees as inextricably linked to US national failure in war and the tragedy of an individual soldier’s PTSD. Such sentiments seem intimately connected to Donald Trump’s version of America, and its need to exercise global power. Kyle died before Trump’s election, but it seems evident that such rage, anger and alienation experienced by a vast segment of the American population contributed to the election result (Kluger). Calm Cold Calculation Ironically, the traditional sniper embodies the antithesis of hot-blooded rage. Firing any long- distance range weapon with accuracy requires discipline, steady breathing and intense muscle control. Olympic shooting or pentathlons demonstrate this, and Gina Cavallaro and Matt Larsen chronicle both sniper training and the sniper experience in war. So, the notion of sniper shooting and rage can only coexist if we accept that rage becomes the cold, calculating rage of a person doing a highly precise job when killing enemies. In the book, Kyle clearly has no soldierly respect for his Iraqi insurgent enemies and is content to shoot them down one by one. In the film, there is greater emphasis on Kyle having more complex emotions based around the desire to protect his fellow soldiers by shooting in a calm and detached fashion at his designated targets.Chris Kyle’s determination to kill his enemies regardless of age or gender seems at odds with the calm detached passivity of the sniper. The long-distance shooter should be dispassionate but Kyle experiences rage as he kills to protect his fellow soldiers. Can we argue he exhibits ‘cold rage’ not ‘hot rage’, but rage none the less? It would certainly seem so. War Hero and Fantasist?In life, as in death, Chris Kyle presents a figure of controversy, being praised by the political far right, yet condemned by a diverse coalition that included radicals, liberals, and even conservatives such as former soldier Michael Fumento. Fumento commented that Kyle’s literary embellishments and emphasis on his own prowess denigrated the achievements of fellow American snipers. Reviewer Lindy West described him as “a hate filled killer”, only to become a recipient of rage and hatred from Kyle supporters. Paul Rieckhoff described the film as not the most complex nor deepest nor provocative, but the best film made about the Iraq war for its accuracy in storytelling and attention to detail.Elsewhere, reviewer Mark Kermode argues that the way the film is made introduces a significant ambiguity: that we as an audience can view Kyle as either a villain, a hero, or a combination of both. Critics have also examined Kyle’s reportage on his military exploits, where it seems he received less fewer medals than he claimed, as well as his ephemeral assertion that he shot looters in the aftermath of Hurricane Katrina (Lamothe). In other claims, the US courts have upheld the assertion of former wrestler turned politician Jesse Ventura that Kyle fabricated a bar-room brawl between the two. But humans are complex beings, and Drew Blackburn sees it as “entirely plausible to become both a war hero and a liar” in his candid (Texas-based) assessment of one person who was, like many of us, a multifaceted figure.Conclusion This article has addressed the complicated issues of rage originating in the historical background of military actions that have taken place in the East/West conflicts in the Middle East that began in the region after the Second World War, and continue to the present day. Rage has become a popular trope within popular culture as military chic becomes ‘all the rage’. Rage is inextricably linked to the film American Sniper. Patriotism and love of his fellow soldiers motivated Chris Kyle, and his determination to kill his country’s enemies in Iraq and protect the lives of his fellow American soldiers is clear, as is his disdain for both his Iraqi allies and enemies. With an ever- increasing number of mass shootings in the United States, the military sniper will be a hero revered by some and a villain reviled by others. Rage infuses the film American Sniper, whether the rage of battle, rage at the moral dilemmas his role demands, domestic rage between husband and wife, PTSD rage, or rage inspired following his pointless murder. But rage, even when it expresses a complex vortex of emotions, remains dangerous for those who are obsessed with guns, and look to killing others either as a ‘duty’ or to soothe an individual crisis of confidence. ReferencesAmerican Sniper. Dir. Clint Eastwood. Warner Brothers, 2014.Beck, Bernard. “If I Forget Thee: History Lessons in Selma, American Sniper, and A Most Violent Year.” Multicultural Perspectives 17.4 (2015): 215-19.Black, Jeremy. War and the Cultural Turn. Cambridge: Polity Press, 2012.Blackburn, Drew. “How We Talk about Chris Kyle.” Texas Monthly 2 June 2016. 18 Feb. 2019 <https://www.texasmonthly.com/the-daily-post/chris-kyle-rorschach/>.Cavallaro, Gina, and Matt Larsen. Sniper: American Single-Shot Warriors in Iraq and Afghanistan. Guildford, Connecticut: Lyons, 2010. Enemy at the Gates. Dir. Jean-Jaques Annaud. Paramount/Pathe, 2001.Fisk, Robert. The Great War for Civilisation: The Conquest of the Middle East. New York: Alfred A. Knopf, 2006.Fumento, Michael. “American Sniper’s Myths and Misrepresentations.” The American Conservative 13 Mar. 2015. 18 Feb. 2019 <https://www.theamericanconservative.com/articles/clint-eastwoods-fabricated-sniper/>.Gildersleeve, Jessica, and Richard Gehrmann. “Memory and the Wars on Terror”. Memory and the Wars on Terror: Australian and British Perspectives. Eds. Jessica Gildersleeve and Richard Gehrmann. Cham: Palgrave Macmillan, 2017. 1-19.Grossman, Dave. On Killing: The Psychological Cost of Learning to Kill in War and Society. Boston: Little, Brown, 1995.Hassan, Hassan. “The True Origins of ISIS.” The Atlantic 30 Nov. 2018. 17 Feb. 2019 <https://www.theatlantic.com/ideas/archive/2018/11/isis-origins-anbari-zarqawi/577030/>.Kermode, Mark. “American Sniper Review – Bradley Cooper Stars in Real-Life Tale of Legendary Marksman.” The Guardian 18 Jan. 2015. 18 Feb. 2019 <https://www.theguardian.com/film/2015/jan/18/american-sniper-review-bradley-cooper-real-life-tale-legendary-marksman>.Kluger, Jeffrey. “America's Anger Is Out of Control.” TIME 1 June 2016. 17 Feb. 2019 <http://time.com/4353606/anger-america-enough-already>.Kyle, Chris. American Sniper. New York: Harper, 2012. Junger, Sebastian. Tribe: On Homecoming and Belonging. London: Fourth Estate, 2016.Lamothe, Dan. “How ‘American Sniper’ Chris Kyle’s Truthfulness Is in Question Once Again.” 25 May 2016. 19 Feb. 2019 <https://www.washingtonpost.com/news/checkpoint/wp/2016/05/25/how-american-sniper-chris-kyles-truthfulness-is-in-question-once-again/?noredirect=on&utm_term=.d8806f2b8d3a>.Lembcke, Jerry. PTSD: Diagnosis and Identity in Post-Empire America. Lanham: Lexington Books, 2013.Pomarède, Julien. “Normalizing Violence through Front-Line Stories: The Case of American Sniper.” Critical Military Studies 4.1 (2018): 52-71. Rall, Denise N. “Afterword: The Military in Contemporary Fashion.” Fashion and War in Popular Culture. Ed. Denise N. Rall. Bristol: Intellect, 2014. 177-179. Rieckhoff, Paul. “A Veteran's View of American Sniper.” Variety 16 Jan. 2015. 19 Feb. 2019 <https://variety.com/2015/film/opinion/a-veterans-view-of-american-sniper-guest-column-1201406349/>.Smith, Heather, and Richard Gehrmann. “Branding the Muscled Male Body as Military Costume.” Fashion and War in Popular Culture. Ed. Denise N. Rall. Bristol: Intellect, 2014. 57-71.Smith, Helena. “Shocking Images of Drowned Syrian Boy Show Tragic Plight of Refugees.” The Guardian 2 Sep. 2015. 17 Feb. 2019 <https://www.theguardian.com/world/2015/sep/02/shocking-image-of-drowned-syrian-boy-shows-tragic-plight-of-refugees>.Stanford, David (ed.). The Sandbox: Dispatches from Troops in Iraq and Afghanistan. Kansas City: Andrews McMeel Publishing, 2007.Taibbi, Matt. “American Sniper Is Almost Too Dumb to Criticise.” Rolling Stone 21 Jan. 2015. <https://www.rollingstone.com/movies/movie-news/american-sniper-is-almost-too-dumb-to-criticize-240955/>.Trudeau, Garry B. The Sandbox: Dispatches from Troops in Iraq and Afghanistan. Kansas City: Andrew McMeel Publishing, 2007.West, Lindy. “The Real American Sniper Was a Hate-Filled Killer: Why Are Simplistic Patriots Treating Him as a Hero?” The Guardian 6 Jan. 2015. 19 Feb. 2019 <https://www.theguardian.com/commentisfree/2015/jan/06/real-american-sniper-hate-filled-killer-why-patriots-calling-hero-chris-kyle>.
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