Relevant bibliographies by topics / Modification of the hyaluronic acid

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  2. Dissertations / Theses
  3. Books
  4. Book chapters
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Academic literature on the topic 'Modification of the hyaluronic acid'

Author: Grafiati
Published: 28 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "Modification of the hyaluronic acid"

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Lapčík, L., K. Benešová, L. Lapčík, S. De Smedt, and B. Lapčíková. "Chemical Modification of Hyaluronic Acid: Alkylation." International Journal of Polymer Analysis and Characterization 15, no. 8 (November 23, 2010): 486–96. http://dx.doi.org/10.1080/1023666x.2010.520904.

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Ponedel?kina, I. Yu, V. N. Odinokov, E. S. Vakhrusheva, M. T. Golikova, L. M. Khalilov, and U. M. Dzhemilev. "Modification of hyaluronic acid with aromatic amino acids." Russian Journal of Bioorganic Chemistry 31, no. 1 (January 2005): 82–86. http://dx.doi.org/10.1007/s11171-005-0011-y.

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Kuo, Jing Wen, David A. Swann, and Glenn D. Prestwich. "Chemical modification of hyaluronic acid by carbodiimides." Bioconjugate Chemistry 2, no. 4 (July 1991): 232–41. http://dx.doi.org/10.1021/bc00010a007.

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Zhang, Xin, Pengcheng Sun, Lingzi Huangshan, Bi-Huang Hu, and Phillip B. Messersmith. "Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation." Chemical Communications 51, no. 47 (2015): 9662–65. http://dx.doi.org/10.1039/c5cc02367j.

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Baker, Anna. "The evidence behind the biophysical properties of hyaluronic acid dermal fillers." Journal of Aesthetic Nursing 10, Sup1 (February 1, 2021): 39–42. http://dx.doi.org/10.12968/joan.2021.10.sup1.39.

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With the breadth and variety of hyaluronic acid hydrogels available, it can be challenging to understand the evolving product characteristics and associated terminology. Similarly, different hyaluronic acid hydrogels can share the same indication, and yet consist of different rheological and physiochemical properties. In this paper, hyaluronic acid biophysical properties, such as molecular weights, stabilisation (crosslinking), modification and hyaluronic acid concentration, are explored in relation to findings from current literature. The significance for these specific properties is explored in relation to specific indications and anti-ageing benefits.
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Laffleur, Flavia, Julia Röggla, Muneeb Ahmad Idrees, and Julia Griessinger. "Chemical Modification of Hyaluronic Acid for Intraoral Application." Journal of Pharmaceutical Sciences 103, no. 8 (August 2014): 2414–23. http://dx.doi.org/10.1002/jps.24060.

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Roberts, C. R., P. J. Roughley, and J. S. Mort. "Degradation of human proteoglycan aggregate induced by hydrogen peroxide. Protein fragmentation, amino acid modification and hyaluronic acid cleavage." Biochemical Journal 259, no. 3 (May 1, 1989): 805–11. http://dx.doi.org/10.1042/bj2590805.

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We have previously shown that treatment of neonatal human articular-cartilage proteoglycan aggregates with H2O2 results in loss of the ability of the proteoglycan subunits to interact with hyaluronic acid and in fragmentation of the link proteins [Roberts, Mort & Roughley (1987) Biochem. J. 247, 349-357]. We now show the following. (1) Hyaluronic acid in proteoglycan aggregates is also fragmented by treatment with H2O2. (2) Although H2O2 treatment results in loss of the ability of the proteoglycan subunits to interact with hyaluronic acid, the loss of this function is not attributable to substantial cleavage of the hyaluronic acid-binding region of the proteoglycan subunits. (3) In contrast, link proteins retain the ability to bind to hyaluronic acid following treatment with H2O2. (4) The interaction between the proteoglycan subunit and link protein is, however, abolished. (5) N-Terminal sequence analysis of the first eight residues of the major product of link protein resulting from H2O2 treatment revealed that cleavage occurred between residues 13 and 14, so that the new N-terminal amino acid is alanine. (6) In addition, a histidine (residue 16) is converted into alanine and an asparagine (residue 21) is converted into aspartate by the action of H2O2. (7) Rat link protein showed no cleavage or modifications in similar positions under identical conditions. (8) This species variation may be related to the different availability of histidine residues required for the co-ordination of the transition metal ion involved in hydroxyl-radical generation from H2O2. (9) Changes in function of these structural macromolecules as a result of the action of H2O2 may be consequences of both fragmentation and chemical modification.
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Santaella-Sosa, Erick. "Hyaluronic acid filler vascular complication management: an updated and easy-to-follow emergency protocol." Journal of Aesthetic Nursing 10, Sup1 (February 1, 2021): 34–38. http://dx.doi.org/10.12968/joan.2021.10.sup1.34.

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With the breadth and variety of hyaluronic acid hydrogels available, it can be challenging to understand the evolving product characteristics and associated terminology. Similarly, different hyaluronic acid hydrogels can share the same indication, and yet consist of different rheological and physiochemical properties. In this paper, hyaluronic acid biophysical properties, such as molecular weights, stabilisation (crosslinking), modification and hyaluronic acid concentration, are explored in relation to findings from current literature. The significance for these specific properties is explored in relation to specific indications and anti-ageing benefits.
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Lin, Quan Kui, Xiao Jie Huang, Jun Mei Tang, and Hao Chen. "Facile and Efficient Anti-Fouling Surface Construction on Poly(dimethylsiloxane) via Mussel-Inspired Chemistry." Advanced Materials Research 749 (August 2013): 344–49. http://dx.doi.org/10.4028/www.scientific.net/amr.749.344.

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Poly (dimethylsiloxane) (PDMS) silicones have found many applications in biomedical devices, such as catheters and intraocular lenses. But their hydrophobicity makes the possibility of the unexpected bioadhesion. In this paper, we reported a facile and efficient anti-fouling surface modification method on PDMS via self-polymerization of dopamine and the followed hyaluronic acid immobilization. Dopamine, commonly used as a neurotransmitter, is also a small molecule mimic of the adhesive proteins of mussels. Self-polymerization of dopamine can produce a thin polydopamine (PDA) layer on PDMS surface. Subsequently, thiol group functionalized hyaluronic acid (denoted as HA-SH) was immobilized covalently onto the resultant surface by the coupling between thiol group and reactive polydopamine layer. Then, the in vitro adhesion behaviors of the lens epithelial cells (LECs) and macrophage were investigated for evalution the anti-fouling effect of the hyaluronic acid modified PDMS surface. The results indicated that the cellular adhesion on PDMS were greatly decreased after hyaluronic acid modification, which suggested the potential application of such hyaluronic acid modified PDMS in biomedical applications.
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Kim, Jongho, Chaemyeong Lee, and Ji Hyun Ryu. "Adhesive Catechol-Conjugated Hyaluronic Acid for Biomedical Applications: A Mini Review." Applied Sciences 11, no. 1 (December 22, 2020): 21. http://dx.doi.org/10.3390/app11010021.

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Recently, catechol-containing polymers have been extensively developed as promising materials for surgical tissue adhesives, wound dressing, drug delivery depots, and tissue engineering scaffolds. Catechol conjugation to the polymer backbone provides adhesive properties to the tissue and does not significantly affect the intrinsic properties of the polymers. An example of a catecholic polymer is catechol-conjugated hyaluronic acid. In general, hyaluronic acid shows excellent biocompatibility and biodegradability; thus, it is used in various medical applications. However, hyaluronic acid alone has poor mechanical and tissue adhesion properties. Catechol modification considerably increases the mechanical and underwater adhesive properties of hyaluronic acid, while maintaining its biocompatibility and biodegradability and enabling its use in several biomedical applications. In this review, we briefly describe the synthesis and characteristics of catechol-modified hyaluronic acid, with a specific focus on catechol-involving reactions. Finally, we discuss the basic concepts and therapeutic effects of catechol-conjugated hyaluronic acid for biomedical applications.
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Dissertations / Theses on the topic "Modification of the hyaluronic acid"

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Courtney, Margaret Ellen Louise. "Characterisation and modification of prokaryotic hyaluronic acid." Thesis, University of Strathclyde, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249767.

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Schanté, Carole. "Chemical modifications of hyaluronic acid for the development of bioresorbable medical devices." Strasbourg, 2011. http://www.theses.fr/2011STRA6198.

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L’objectif de ce travail de thèse était de développer un nouveau dérivé d’acide hyaluronique (HA) ayant une action thérapeutique plus longue que les produits actuellement sur le marché. Une modification chimique efficace constistant en le greffage d’acides aminés sur les groupements carboxyliques de l’HA permis d’obtenir des dérivés ayant une meilleure résistance enzymatique in vitro comparée à l’HA de départ. Trois réactions d’amidation ont été évaluées pour l’obtention de taux de greffage élevés. La prochaine étape a porté sur la réticulation des dérivés HA-acides aminés qui a été accomplie avec le butanediol diglycidyl ether (BDDE) en tant qu’agent réticulant en milieu acide. Les hydrogels réticulés ainsi obtenus ont présenté une meilleure résistance in vitro à la dégradation enzymatique en présence de hyaluronidases en comparaison avec les hydrogels réticulés obtenus à partir de l’HA sans acide aminé et avec les produits commerciaux
The aim of this work was to develop a novel hyaluronic acid (HA) product having a longer therapeutic action compared to the products currently on the market. An efficient chemical modification consisting of grafting amino acids onto the carboxylic groups of HA showed to yield derivatives significantly more resistant to in vitro enzymatic digestion than the native HA. Three amidation reactions were evaluated for an efficient grafting of the amino acid onto the carboxylic groups of HA. The next step was to form crosslinked hydrogels from the HA-amino acid derivatives and was achieved by using the crosslinking agent butanediol diglycidyl ether (BDDE) in acidic media. The resulting crosslinked HA-amino acid hydrogels exhibited a higher in vitro resistance to hyaluronidase degradation compared to the hydrogels obtained from native HA in the same conditions, and compared to commercially available hyaluronic acid products
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Hrochová, Eliška. "Derivatizace hyaluronanu sodného jakožto nástroj pro zvýšení stability modelové artificiální synoviální kapaliny." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-444537.

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This master thesis deals with the optimization of the procedure of modification of hyaluronic acid structure for the use in the artificial synovial liquids. Based on the literature research, the amino acid alanine was used for the modification of carboxylic group in the glucuronic acid. The main subject of study is the improvement of the stability and mechanical properties of synovial liquid. DLS microrheology, macrorheology, thermogravimetric analysis (TGA), multi-angle light scattering with flow-field flow fractionation (AF4-MALS) and infrared spectroscopy (FTIR) were used for characterization. The theoretical part of this theses submits review of the musculoskeletal system, role of hyaluronic acid in metabolism and summary of synovial liquid. The experimental part focuses on the measurement of the stability and mechanical properties of three artificial samples (first with no modification, second with modified hyaluronic acid and third with modified hyaluronic acid and chondroitin sulphate). These samples were compared with real horse synovial fluid and artificial viscosupplement Orthovisc®.
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Odehnalová, Nikola. "Příprava nanočástic a jejich využití jako kontrastních látek pro in vivo zobrazování." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2020. http://www.nusl.cz/ntk/nusl-414183.

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This diploma thesis deals with the optimalization of synthesis of gold nanoparticles and their surface modification allowing their use as contrast agents for in vivo imaging by CT. Gold nanoparticles were prepared by the Turkevich method and characterized by TEM, DLS, MADLS and UV -Vis. Their surface was functionalized with polyethylene glycol containing a thiol group forming a bond with the Au atoms in the surface of gold nanoparticles. The terminal end of the polymer was methylated or containing an aminooxy group forming an orthogonal bond with hyaluronic acid using click-chemistry. The eligibility for in vivo application of the prepared nanoparticles was verified with stability and cytotoxicity tests. The nanoparticles modified by methylated polyethyleneglycol were injected intravenously into a mouse and their application potential as contrast agents were verified by CT.
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Young, Denice Shanette. "Hyaluronic Acid-based Nanofibers via Electrospinning." NCSU, 2006. http://www.lib.ncsu.edu/theses/available/etd-08162006-095122/.

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Electrospinning is a novel technology that uses an electric field to form fibrous materials from a polymer solution. Unlike traditional spinning techniques, electrospinning can produce fibers, on the order of 100 nm, that can be utilized in applications where nanoscale fibers are necessary for specific applications, including tissue engineering and filtration. Outside of a smaller fiber diameter, electrospun nanofibers are also advantageous for biomedical applications because they have a larger surface area and pore size which promotes cell growth. A number of polymers have been electrospun successfully, including polyethylene (PEO) and polyvinyl chloride (PVC), which are two the most investigated electrospun materials. For the purpose of this study, hyaluronic acid (HA), a widely used biopolymer found in the extracellular matrix, was the chosen polymer to investigate the successful production of HA nanofibers for use in tissue engineering. Few studies have been conducted on electrospinning HA. Indeed, when this project was initiated, no investigations on electrospinning HA had been published. The goal of this research was to produce continuous fibrous strands of HA to be used as a mesh or scaffolding material. The high viscosity and surface tension of HA make it challenging to electrospin, as both are important parameters in successful production of nanofibers. To promote HA fiber formation by electrospinning, the effects of salt (NaCl), which is used to reduce the viscosity of aqueous HA solutions; molecular weight of the HA; and an additional biocompatible polymer (e.g., PEO) were investigated.
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Sjögren, Frida. "Microstructuring of Hyaluronic acid cell culture scaffolds." Licentiate thesis, Uppsala universitet, Mikrosystemteknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-334653.

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Ren, Cindy D. "Injectable hyaluronic acid scaffolds for cartilage tissue engineering." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/46025.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2008.
Includes bibliographical references.
Every year tens of millions worldwide suffer from cartilage damage, caused by mechanical degradation, trauma or disease. Because of the lack of blood supply and low cell concentration within the tissue, cartilage has very limited regenerative ability. Although current treatments can provide symptomatic relief, the results vary greatly among individuals, and newly formed tissue often does not duplicate the structure, composition or mechanical properties of normal cartilage. Therefore, in recent years, tissue engineering has emerged as an alternative therapy. Tissue engineering enhances the body's natural healing capacity by providing cells, signaling molecules, and an environment in the form of a scaffold that is conducive to tissue growth. This project has focused on the development of a tissue engineering scaffold for cartilage regeneration. Disadvantages to current scaffolds include the fact that they require surgery for implantation, and that they are difficult to mold to the exact shape of the defect site. Hence, the motivation of this thesis is to develop an injectable scaffold that can be administered in a minimally invasive manner, and that allows for scaffold formation in situ, naturally shaping the construct into the shape of the defect, and thus promoting integration and stability To this end, we have developed a thermoresponsive injectable scaffold for cartilage tissue engineering. The scaffold was injected as a liquid at room temperature, and gelled at the target site in response to the change to body temperature, resulting in a biocompatible, bioresorbable substrate for tissue growth. Our approach involved suspending thermoresponsive liposomes, which encapsulated a crosslinking agent, in a polymer solution. At room temperature, the crosslinking agent was separated from the polymer by the lipid membrane, hence the precursor solution remained a liquid and injectable. Upon injection and exposure to body temperature, the lipids experienced a phase transition, which significantly increased the membrane permeability and led to the release of the crosslinking agent and reaction with the polymer, forming a networked scaffold.
(cont.) The scaffold system that we have chosen is a hyaluronic acid-tyramine system (HA-Tyr) that crosslinked in the presence of H202 and horseradish peroxidase (HRP) to form a hydrogel. Since HA, Tyr, H202 and peroxidases all occur naturally in the body, scaffold formation could take place with minimal toxicity and in the presence of cells as well as in situ. In order to impart temperature sensitivity to this system, HRP was encapsulated within liposomes, and it was shown that HRP was successfully retained at 25°C and released at 37°C. Upon liposome addition to the HA-Tyr/H202 solution, the precursor solution remained a liquid for hours at 25°C, yet gelation could be induced within minutes when exposed to 37°C. Furthermore, it was shown that gelation times could be adjusted to meet various clinical needs by modulating HRP encapsulation, liposome concentration and HA-Tyr concentration. In order to test the potential of the HA-Tyr system for cartilage production, porcine chondrocytes were encapsulated within HA-Tyr/H202/HRP hydrogels and implanted subcutaneously in mice. Harvested constructs were shown to achieve a GAG content of 1.2 wt% and demonstrated 40% of the collagen content of normal articular cartilage. Matrix production was found to be influenced by the initial cell density, scaffold degradation rate and Type II collagen concentration. The means of HRP delivery, whether by simple addition or through thermoreponsive liposomes, was not shown to have an effect on matrix production. Injected scaffolds were shown to achieve GAG and collagen levels similar to that of implanted scaffolds. As signaling molecules have been demonstrated to be potent chondrogenic inducers, PLGA-hydroxyapatite nanocomposite microparticles were utilized for the controlled delivery of TGF-[beta]1 and IGF-1. The rate of growth factor release was modulated by the molecular weight of PLGA within the microparticles; increasing molecular weight led to decreasing release rate. The nanocomposite microparticles were encapsulated within HA-Tyr/H202/HRP/chondrocyte constructs, which were then implanted subcutaneously in mice.
(cont.) Growth factor-induced enhancement of GAG and collagen production was found to be determined by the release rates of TGF-31 and IGF-1, multifactor release, and the dosage of nanocomposite microparticles. Injection of the microparticles with an HA-Tyr/H202/HRP liposome/chondrocyte/collagen solution also showed that the microparticles did not interfere with in situ scaffold formation, and could induce significant improvements to GAG and collagen production in the injectable system.
by Cindy D. Ren.
Ph.D.
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Almalik, Abdulaziz. "Hyaluronic acid-coated nanoparticles as biofunctional pharmaceutical carriers." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/hyaluronic-acidcoated-nanoparticles-as-biofunctional-pharmaceutical-carriers(6812b8ca-0341-4473-abbe-b5059d30f8bc).html.

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In recent years, the use of nanotechnology for drug delivery purposes has witnessed a very significant growth aiming to improve the efficacy and/or reduce toxicity of existing drugs. This project aimed to design hyaluronic acid (HA)-coated chitosan-triphosphate (TPP) nanoparticles applicable for the delivery of genetic payload, and predominantly focused on the study of chitosan molecular weight-dependent effects.Firstly, we explored the effect of chitosan molecular weight (MW) on the physico-chemical characteristics and morphology/structure of chitosan-TPP nanoparticles and their functional behaviour. Combining dynamic light scattering and atomic force microscopy analysis allowed to highlight the influence of chitosan MW on the porosity, environmental response and HA adsorption of the resulting particles. For example, increasing chitosan MW provided increasingly porous nanoparticles. Upon coating with HA, HA showed a different adsorption mode depending on the nanoparticle porosity (and therefore on chitosan MW), with deeper penetration in more porous nanoparticles and the formation of an HA corona for less porous ones. This different mode of HA adsorption on nanoparticles appears to largely influence the enzymatically triggered payload release from the nanoparticles, the protein adsorption on the surface of the nanoparticles and also to affect the overall stability of the nanoparticles.As a spin-off of this study, we became interested in the effect of the different mode of HA adsorption described earlier on the way HA is presented to phagocytic cells (264.7 RAW macrophages), and therefore on the kinetics and possibly also on the mechanism of nanoparticles uptake. Here, we provide conclusive evidence that HA-coated nanoparticle internalisation is a CD44-mediated phenomenon. Interestingly, our data suggest that a better presentation of HA, i.e. hyaluronic acid less tightly complexed on the nanoparticle surface, is linked to both higher affinity and lower capacity/uptake rate. Paradoxically, particles with a lower affinity for CD44 may allow a more efficient HA-mediated delivery of payloads.Finally, we investigated the feasibility of CD44-dependent therapeutic approaches using HA-coated nanoparticles made from different chitosan MWs with or without a nucleic acid payload. The physico-chemical characteristics and nucleic acid encapsulation efficiency were compared. Transfection efficiency in cells characterised by a significantly different expression of CD44 and the possibility for the HA-coated nanoparticles to exert a direct anti-inflammatory effect were also analysed. HA-coated nanoparticles allowed successful entrapment and delivery of both siRNA and pDNA, with significant effects of the nanoparticle bulk structure ( i.e. chitosan MW). We also showed an unprecedented anti-inflammatory effect of HA-coated nanoparticles devoid of any payload, which was more potent than the effect resulting from soluble HA. We speculate that the different organisation and possibly different crowding and mobility of HA chains may give rise to significant effects on macrophage inflammatory activation possibly arising from clustered binding to HA receptors such as CD44. These results indicate the potentiality of CD44-mediated therapies using HA-coated nanoparticles.
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Ouasti, Sihem. "Hyaluronic acid biomaterials for perspective peripheral nerve regeneration." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/hyaluronic-acid-biomaterials-for-perspective-peripheral-nerve-regeneration(ec50c37c-7c3e-4e54-8b97-19cec79bcb17).html.

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This project focused on the design of a cellular scaffold applicable for the promotion of peripheral nerve regeneration. Firstly, we established a correlation between the organization of HA/PEG co-polymeric networks to their mechanical and degradability properties; cell adhesion was conferred to all gels by the incorporation of RGD peptides. Three families of hydrogels were produced using different procedures to permit an increasing physical incorporation of HA into a PEGDA-based network. From a comparative study of rheological properties and enzymatic degradability, co-networks obtained using thiolated HA as chain transfer agent during PEGDA photo-polymerization were selected for further biological investigations, aiming to link the cellular response of L929 murine fibroblasts (phenotype, proliferation rate, metabolic activity) to the composition and the consistency of selected hydrogels. Our findings showed that there is a clear relation between increasing hardness and increasing cell spreading/proliferation rate. This study illustrated the possibility to fine tune cell/material interactions with appropriate reactive processing techniques. As a spin-off of this study, we become interested in the interplay of cellular interactions in the use of materials that contain both HA and RGD peptides, which can bind at the same time to HA receptors such as CD44 and av integrins. We focused on soluble HA derivatives, with or without dandling RGD peptides. The kinetics and the mechanistic details of both HA and HA-RGD internalization were studied in a phagocytic model (J774.2 murine macrophages). HA-RGD showed a form of synergic binding to integrins and CD44 (HA receptor), whereas its uptake remained solely regulated by CD44 dwell-time on the cell membrane. This study demonstrated that the knowledge of the rate-determining steps of the uptake of a carrier is necessary for assessing its efficiency. In this case, the presence of multiple ligands on a carrier was beneficial in some respect, but may not be optimal to overcome internalization limitations that arise from the slow turnover of the determining receptor. Finally, we studied the relation between the regulation of the expression of CD44 / RHAMM (HA receptor mediated motility) and the motility of Schwann cells (peripheral glial cells) and stem cells differentiated into a glial phenotype. Rt-PCR and immuno-assay experiments suggested that RHAMM up-regulation is associated with glial differentiation and we speculate that in the future this HA receptor could be considered as a differentiation marker. We also illustrated the importance of HA / RHAMM interaction for the motility of glial cells. These results indicate the importance of HA in mediating glial cell function during peripheral nerve regeneration and have implications for therapeutic repair strategies.
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McLaughlin, Richard L. "Hyaluronic acid production in continuous cultures of Streptococcus zooepidemicus /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19192.pdf.

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Books on the topic "Modification of the hyaluronic acid"

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Selyanin, Mikhail A., Petr Ya Boykov, Vladimir N. Khabarov, and Felix Polyak. Hyaluronic Acid. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118695920.

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Hyaluronan: From basic science to clinical applications. Edgewater, New Jersey: PubMatrix, 2011.

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Practical aspects of hyaluronan based medical products. Boca Raton: Taylor & Francis, 2006.

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Ya, Boykov P., and Selyanin, M. A. (Michael A.), eds. Hyaluronic acid: Preparation, properties, application in biology and medicine. Chichester, West Sussex: John Wiley & Sons, Inc., 2015.

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Myint, Pe. Free radical reactions of hyaluronic acid in aqueous solution. Salford: University of Salford, 1991.

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Bo li suan yan jiu yu ying yong: Hyaluronan. Beijing Shi: Ren min wei sheng chu ban she, 2010.

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Peixue, Ling, Rong Xiaohua, and Zhang Tianmin, eds. Xiu wai hui zhong: Shen qi de zhi neng tou ming zhi suan. Beijing Shi: Zhongguo fang zhi chu ban she, 2005.

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Starnes, Hazel Louise. The role of copper in the free radical depolymerisation of hyaluronic acid. Salford: University of Salford, 1995.

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Lapakko, Kim A. Modification of the net acid production (NAP) test. S.l: s.n, 1993.

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Sonia, Weiss, and Copyright Paperback Collection (Library of Congress), eds. Restylane. New York: Berkley Books, 2003.

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Book chapters on the topic "Modification of the hyaluronic acid"

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Bebe, Siziwe, and Tassos Anastassiades. "Chemical Modification of the N-Acetyl Moieties of Hyaluronic Acid from Streptococcus equi for Studies in Cytokine Production." In Methods in Molecular Biology, 99–113. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9154-9_9.

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Swann, David A., and Jing-wen Kuo. "Hyaluronic acid." In Biomaterials, 285–305. London: Palgrave Macmillan UK, 1991. http://dx.doi.org/10.1007/978-1-349-11167-1_6.

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Bährle-Rapp, Marina. "Hyaluronic Acid." In Springer Lexikon Kosmetik und Körperpflege, 262. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_4838.

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Ohmae, Masashi, and Shunsaku Kimura. "Hyaluronic Acid." In Encyclopedia of Polymeric Nanomaterials, 944–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-29648-2_413.

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Ohmae, Masashi, and Shunsaku Kimura. "Hyaluronic Acid." In Encyclopedia of Polymeric Nanomaterials, 1–11. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-36199-9_413-1.

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Allegra, Luigi, Sabrina Della Patrona, and Giuseppe Petrigni. "Hyaluronic Acid." In Heparin - A Century of Progress, 385–401. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-23056-1_17.

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Pereira, Hélder, Duarte Andre Sousa, António Cunha, Renato Andrade, J. Espregueira-Mendes, J. Miguel Oliveira, and Rui L. Reis. "Hyaluronic Acid." In Osteochondral Tissue Engineering, 137–53. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-76735-2_6.

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Shah, Chirag B., and Stanley M. Barnett. "Hyaluronic Acid Gels." In Polyelectrolyte Gels, 116–30. Washington, DC: American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0480.ch007.

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Nestor, Mark S., Emily L. Kollmann, and Nicole Swenson. "Hyaluronic Acid Fillers." In Cosmetic Dermatology, 375–79. Oxford, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118655566.ch41.

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Hildebrand, Hartmut F., and Nicolas Blanchemain. "Collagen and Hyaluronic Acid." In Cartilage Surgery and Future Perspectives, 87–95. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-19008-7_10.

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Conference papers on the topic "Modification of the hyaluronic acid"

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Klicova, Marketa, Lukas Volesky, Andrea Klapstova, Vaclav Liska Jachym Rosendorf, Richard Palek, and Jana Horakova. "Hydrophobic Ultrafine Hyaluronic Acid Nanofibers." In The 5th World Congress on New Technologies. Avestia Publishing, 2019. http://dx.doi.org/10.11159/icnfa19.151.

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Chulho Shin, Sumi Kim, Seongyeon Jo, and Insup Noh. "Biological characterizations of hyaluronic acid hydrogel particles." In 2011 IEEE Nanotechnology Materials and Devices Conference (NMDC 2011). IEEE, 2011. http://dx.doi.org/10.1109/nmdc.2011.6155292.

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Zheng, Shaohui, Sunghoon Cho, Van Du Nguyen, Eunpyo Choi, Jiwon Han, and Jong-Oh Park. "Development of hyaluronic acid microcargo for therapeutic bacteriobots." In 2017 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS). IEEE, 2017. http://dx.doi.org/10.1109/marss.2017.8001912.

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Bick, A., E. Gomez, H. Shin, M. Brigham, M. Vu, and A. Khademhosseini. "Fabrication of microchannels in methacrylated hyaluronic acid hydrogels." In 2009 IEEE 35th Annual Northeast Bioengineering Conference. IEEE, 2009. http://dx.doi.org/10.1109/nebc.2009.4967833.

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Rudolph, J., A. Dietz, P. Meier, S. Grunewald, and S. Wiegand. "Severe embolism after injection rhinoplasty with hyaluronic acid." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686642.

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El-Fakhri, S., V. Holcman, and K. Liedermann. "Dielectric spectroscopy of hyaluronic acid and its salts." In 2008 International Symposium on Electrical Insulating Materials (ISEIM). IEEE, 2008. http://dx.doi.org/10.1109/iseim.2008.4664539.

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Kalkandelen, Cevriye, Sena Su, Elif Saatcioglu, and Oguzhan Gunduz. "Hyaluronic Acid Production and Analysis from Rooster Comb." In 2020 Medical Technologies Congress (TIPTEKNO). IEEE, 2020. http://dx.doi.org/10.1109/tiptekno50054.2020.9299240.

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Papakonstantinou, Eleni, Leticia Grize, Hans Hirsch, Michael Tamm, and Daiana Stolz. "Hyaluronic acid in COPD exacerbations of different etiology." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.967.

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Kim, Jungju, In Sook Kim, Soon Jung Hwang, Ho Chul Kim, Yongdoo Park, and Kyung Sun. "Bone regeneration using MMP sensitive-hyaluronic acid based hydrogels." In 2009 IEEE 35th Annual Northeast Bioengineering Conference. IEEE, 2009. http://dx.doi.org/10.1109/nebc.2009.4967789.

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"Effect of hyaluronic acid on friction of articular cartilage." In Engineering Mechanics 2018. Institute of Theoretical and Applied Mechanics of the Czech Academy of Sciences, 2018. http://dx.doi.org/10.21495/91-8-709.

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Reports on the topic "Modification of the hyaluronic acid"

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Padalecki, Susan S. Hyaluronic Acid as a Target for Intervention in Prostate Cancer Metastases. Fort Belvoir, VA: Defense Technical Information Center, June 2012. http://dx.doi.org/10.21236/ada567469.

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Prestwich, Glenn D. Targeted Chemotherapy of Tumors and Metastases With Hyaluronic Acid-Anti-Tumor Bioconjugates. Fort Belvoir, VA: Defense Technical Information Center, August 2001. http://dx.doi.org/10.21236/ada398191.

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Prestwich, Glenn D. Targeted Chemotherapy of Tumors and Metastases With Hyaluronic Acid-Anti-Tumor Bioconjugates. Fort Belvoir, VA: Defense Technical Information Center, August 1999. http://dx.doi.org/10.21236/ada383364.

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Gooz, Pal. Hyaluronic Acid is Overexpressed in Fibrotic Lung Tissue and Promotes Collagen Expression. Fort Belvoir, VA: Defense Technical Information Center, April 2009. http://dx.doi.org/10.21236/ada504117.

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Gooz, Pal. Hyaluronic Acid is Overexpressed in Fibrotic Lung Tissue and Promotes Collagen Expression. Fort Belvoir, VA: Defense Technical Information Center, April 2008. http://dx.doi.org/10.21236/ada483207.

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Zhou, Xing, Ke-meng Xiang, and Xiang-yao Yuan. A comparison of the effects of Acupoint injection combined with Hyaluronic Acid versus isolated Hyaluronic Acid for knee osteoarthritis:Protocol for systematic review and meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2020. http://dx.doi.org/10.37766/inplasy2020.10.0058.

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Lokeshwar, Vinata B. Hyaluronic Acid and Hyaluronidase in Prostate Cancer: Evaluation of Their Therapeutic and Prognostic Potential. Fort Belvoir, VA: Defense Technical Information Center, January 2005. http://dx.doi.org/10.21236/ada434622.

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Mladenova, Ralitsa, Ognian Sabotinov, Yordanka Karakirova, Maya Shopska, and Magdalina Gyurova. Preliminary Study on Lasers and X-Ray Irradiation Effects on Hyaluronic Acid Dermal Fillers. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, November 2018. http://dx.doi.org/10.7546/crabs.2018.11.02.

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Lokeshwar, Vinata B. Hyaluronic Acid and Hyaluronidase in Prostate Cancer: Evaluation of Their Therapeutic and Prognostic Potential. Fort Belvoir, VA: Defense Technical Information Center, January 2004. http://dx.doi.org/10.21236/ada422975.

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Mitchell, J. D., R. Lee, G. T. Hodakowski, K. Neya, and W. Harringer. Prevention of Postoperative Pericardial Adhesions with a Hyaluronic Acid Coating Solution: Experimental Safety and Efficacy Studies. Fort Belvoir, VA: Defense Technical Information Center, September 1993. http://dx.doi.org/10.21236/ada360178.

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