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Journal articles on the topic 'Modelli ex vivo'

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Published: 9 March 2023
Last updated: 10 March 2023

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1

ZORBOZAN, Orçun, Mehmet HARMAN, Vedat EVREN, Mümin Alper ERDOĞAN, Aslı KILAVUZ, Varol TUNALI, İbrahim ÇAVUŞ, Özlem YILMAZ, Ahmet ÖZBİLGİN, and Nevin TURGAY. "Glia Hücrelerinin Antimona Dirençli Leishmania tropica ile Enfekte Edilmesi: Yeni Bir ex-vivo Modeli." Mikrobiyoloji Bulteni 52, no. 1 (January 15, 2018): 49–55. http://dx.doi.org/10.5578/mb.66350.

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2

Köhrmann, K., J. Bensemann, F. Kahmann, A. Weber, J. Florian, Ch Bührle, J. Teubner, J. Rassweiler, and P. Alken. "Die stoßwellen-induzierte Gefäßläsion am Ex-vivo-Modell der isolierten, perfundierten Schweineniere." Aktuelle Urologie 25, no. 05 (September 1994): 298–304. http://dx.doi.org/10.1055/s-2008-1058243.

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3

Stadlbauer, C., S. Golovchenko, L. Englert, M. Spaeth, M. Hoenicka, H. S. Hofmann, and M. Ried. "Organbadversuche an humanen Pulmonalgefäßen: Beurteilung der Medikamentenwirkung zur Behandlung der pulmonalarteriellen Hypertonie." Pneumologie 75, no. 05 (January 20, 2021): 369–76. http://dx.doi.org/10.1055/a-1332-6892.

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ZusammenfassungIn der Therapie der pulmonalarteriellen Hypertonie (PAH) kommen zahlreiche Medikamentenklassen zum Einsatz, u. a. Endothelinrezeptorantagonisten (ERA) und Phosphodiesterase-5-(PDE-5-)Inhibitoren. In einem humanen Ex-vivo-Modell sollte überprüft werden, ob durch die Kombination zweier Substanzklassen ein höherer Effekt erzielt werden kann oder – bei gleichem Effekt – eine niedrigere Dosierung der Einzelsubstanzen ausreicht. Wir etablierten ein Organbadmodell, welches uns die In-vitro-Untersuchung der dosisabhängigen Effekte von ERA und PDE-5-Inhibitoren auf die durch Norepinephrin und Endothelin-1 induzierte Kontraktilität humaner Pulmonalgefäße sowie den Vergleich von Mono- und Dualtherapie ermöglichte. Auch wenn die Übertragung der Ex-vivo-Daten auf die Situation im Patienten mit Vorsicht erfolgen muss, so hat sich das Organbad dennoch als hilfreiches Instrument zur Evaluation der dosisabhängigen Effekte von ERA, PDE-5-Inhibitoren und deren Kombination erwiesen. Die Wirksamkeit der Kombinationstherapie und das Potenzial zur Dosisreduktion waren in diesem Modell abhängig von den verwendeten Konzentrationen und vom Einfluss der Vorerkrankungen auf die Blutgefäßfunktion. Diese Arbeit beschreibt die bisherigen und wichtigsten Ergebnisse unserer experimentellen Untersuchungen und gibt einen Ausblick auf zukünftige Projekte.
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Kirschbaum, A., T. Sasse, and E. Palade. "Berstdrücke an der zentralen Pulmonalarterie nach bipolarer Gefäßversiegelung – Untersuchungen an einem Ex-vivo-Modell." Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie 139, no. 03 (January 7, 2014): 342–45. http://dx.doi.org/10.1055/s-0033-1350858.

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Ahmadli, G., R. Schnabel, A. Jokuszies, P. Vogt, U. Zier, and U. Mirastschijski. "Einfluss von Mars- und Mondstaubanaloga auf die Wundheilung humaner Haut im ex-vivo Modell." Handchirurgie · Mikrochirurgie · Plastische Chirurgie 46, no. 06 (November 20, 2014): 361–68. http://dx.doi.org/10.1055/s-0034-1394419.

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6

Zokai, K., L. Piazolo, T. Fenyvesy, U. Hoffmann, G. Huhle, and J. Harenberg. "Wirkung von Thrombininhibitoren auf ein humanes, experimentelles Thrombosemodell zur Vermeidung von Tierversuchen." Hämostaseologie 20, no. 04 (2000): 201–4. http://dx.doi.org/10.1055/s-0037-1619493.

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ZusammenfassungDie Entwicklungen neuer Antithrombotika mit Wirkung auf das Gerinnungssystem oder die Rezeptoren der Thrombozyten stellen einen wichtigen Schwerpunkt in der medizinischen Forschung dar. Im Rahmen dieser Entwicklungsprojekte sind die Ergebnisse zur Wirksamkeit in Thrombosemodellen am Tier von entscheidender Bedeutung. Ihre Übertragbarkeit auf den Menschen wird jedoch kritisch beurteilt. In einem Ex-vivo-Thrombosemodell mit humanem Vollblut wurden daher zunächst die Dosisabhängigkeit von Thrombininhibitoren geprüft, um die Aussagefähigkeit des Modells zu belegen.
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Di Lullo, A. M., M. Scorza, F. Amato, M. Comegna, V. Raia, L. Maiuri, G. Ilardi, E. Cantone, G. Castaldo, and M. Iengo. "An “ex vivo model” contributing to the diagnosis and evaluation of new drugs in cystic fibrosis." Acta Otorhinolaryngologica Italica 37, no. 3 (June 2017): 207–13. http://dx.doi.org/10.14639/0392-100x-1328.

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La fibrosi cistica (FC) è una malattia autosomica recessiva causata da mutazioni nel gene CFTR (Cystic Fibrosis Transmembrane conductance Regulator). Finora sono state descritte circa 2000 mutazioni, ma per la maggior parte di esse è difficile definirne l’effetto senza complesse procedure in vitro. Abbiamo effettuato il campionamento (mediante brushing), la cultura e l’analisi di cellule epiteliali nasali umane (HNEC) utilizzando una serie di tecniche che possono aiutare a testare l’effetto delle mutazioni CFTR. Abbiamo eseguito 50 brushing da pazienti FC e controlli, e in 45 casi si è ottenuta una coltura positiva. Utilizzando cellule in coltura: i) abbiamo dimostrato l’espressione ampiamente eterogenea del CFTR nei pazienti e nei controlli; ii) abbiamo definito l’effetto di splicing di una mutazione sul gene CFTR; iii) abbiamo valutato l’attività di gating di CFTR in pazienti portatori di differenti mutazioni; iv) abbiamo dimostrato che il butirrato migliora in modo significativo l’espressione di CFTR. I dati provenienti dal nostro studio sperimentale dimostrano che l’uso del modello ex-vivo di cellule epiteliali nasali è un importante e valido strumento di ricerca e di diagnosi nella studio della FC e può anche essere mirato alla sperimentazione ed alla verifica di nuovi farmaci. In definitiva, in base ai nostri dati è possibile esprimere le seguenti conclusioni: 1) il prelievo delle cellule epiteliali nasali mediante brushing è applicabile senza alcuna anestesia ed è ben tollerato da tutti i pazienti affetti da FC (bambini e adulti), è scarsamente invasivo e facilmente ripetibile, è anche in grado di ottenere una sufficiente quantità di HNECs rappresentative, ben conservate, idonee allo studio della funzionalità di CFTR; 2) la conservazione delle cellule prelevate è possibile fino a 48 ore prima che si provveda all’allestimento della coltura e ciò permette di avviare studi multicentrici con prelievi in ogni sede e quindi di ottenere una ampia numerosità campionaria; 3) la coltura di cellule epiteliali nasali può essere considerata un modello adatto a studiare l’effetto molecolare di nuove mutazioni del gene CFTR e/o mutazioni specifiche di pazienti “carriers” dal significato incerto; 4) il modello ex-vivo delle HNECs consente inoltre di valutare, prima dell’impiego nell’uomo, l’effetto di farmaci (potenziatori e/o correttori) sulle cellule di pazienti portatori di mutazioni specifiche di CFTR; tali farmaci possono modulare l’espressione genica del canale CFTR aprendo così nuove frontiere terapeutiche e migliori prospettive di vita per pazienti affetti da una patologia cronica come la Fibrosi Cistica; 5) la metodologia da noi istituita risulta essere idonea alla misura quantitativa, mediante fluorescenza, dell’attività di gating del canale CFTR presente nelle membrane delle cellule epiteliali nasali prelevate da pazienti portatori di differenti genotipi; in tal modo è possibile individuare: a) pazienti FC portatori di 2 mutazioni gravi con un’attività < 10% (in rapporto ai controlli -100%), b) soggetti FC portatori contemporaneamente di una mutazione grave e di una lieve con un’attività tra 10-30%, c) i cosiddetti portatori “carriers”- eterozigoti - con un’attività tra 40-70%. In conclusione la possibilità di misurare l’attività del canale CFTR in HNECs fornisce un importante contributo alla diagnosi di FC, mediante individuazione di un “cut-off diagnostico”, ed anche alla previsione della gravità fenotipica della malattia; quindi quanto rilevabile dalla misura del suddetto canale permette di prospettare per il futuro la possibilità di valutare meglio i pazienti per i quali il test del sudore ha dato risultati ambigui (borderline o negativi). La metodica da noi sperimentata consente anche di monitorare i pazienti durante il trattamento farmacologico, valutando in tal modo i reali effetti delle nuove terapie.
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Jayachandran, Priya, Maria Garcia-Cremades, Katarina Vučićević, Namandjé N. Bumpus, Peter Anton, Craig Hendrix, and Radojka Savić. "A Mechanistic In Vivo / Ex Vivo Pharmacokinetic‐Pharmacodynamic Model of Tenofovir for HIV Prevention." CPT: Pharmacometrics & Systems Pharmacology 10, no. 3 (February 6, 2021): 179–87. http://dx.doi.org/10.1002/psp4.12583.

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9

Kirschbaum, A., C. Rössler, P. Rexin, T. Steinfeldt, D. Bartsch, and N. Mirow. "Bipolare Versiegelung von Lungenvenen mit einem 5- und -10-mm-Instrument – Bestimmung der Berstdrücke an einem Ex-vivo-Modell." Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie 141, no. 03 (March 30, 2016): 330–34. http://dx.doi.org/10.1055/s-0042-100815.

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Berny, Michelle A., Ishan A. Patel, Tara C. White-Adams, Patrick Simonson, András Gruber, Sandra Rugonyi, and Owen J. T. McCarty. "Rational Design of an Ex Vivo Model of Thrombosis." Cellular and Molecular Bioengineering 3, no. 2 (February 9, 2010): 187–89. http://dx.doi.org/10.1007/s12195-010-0103-5.

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Martinek, Jan, Magdalena Stefanova, Stepan Suchanek, Filip Zavada, Barbora Svobodova, Alice Strosova, and Miroslav Zavoral. "Training of Different Endoscopic Skills on Ex-Vivo Animal Model." Simulation in Healthcare: The Journal of the Society for Simulation in Healthcare 9, no. 2 (April 2014): 112–19. http://dx.doi.org/10.1097/sih.0b013e31829be99e.

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12

Begemann, P., A. Mahnken, T. Ries, D. Briem, C. Nolte-Ernsting, G. Adam, and A. Koops. "16-Zeilen-Spiral-CT des knöchernen Beckens nach Schraubenosteosynthese der iliosakralen Gelenke - Untersuchungen zur Dosisanpassung in einem Ex-vivo-Modell." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 178, no. 10 (September 2006): 1022–27. http://dx.doi.org/10.1055/s-2006-926953.

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13

Sachs, David, Adam Wahlsten, Sebastian Kozerke, Gaetana Restivo, and Edoardo Mazza. "A biphasic multilayer computational model of human skin." Biomechanics and Modeling in Mechanobiology 20, no. 3 (February 10, 2021): 969–82. http://dx.doi.org/10.1007/s10237-021-01424-w.

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AbstractThe present study investigates the layer-specific mechanical behavior of human skin. Motivated by skin’s histology, a biphasic model is proposed which differentiates between epidermis, papillary and reticular dermis, and hypodermis. Inverse analysis of ex vivo tensile and in vivo suction experiments yields mechanical parameters for each layer and predicts a stiff reticular dermis and successively softer papillary dermis, epidermis and hypodermis. Layer-specific analysis of simulations underlines the dominating role of the reticular dermis in tensile loading. Furthermore, it shows that the observed out-of-plane deflection in ex vivo tensile tests is a direct consequence of the layered structure of skin. In in vivo suction experiments, the softer upper layers strongly influence the mechanical response, whose dissipative part is determined by interstitial fluid redistribution within the tissue. Magnetic resonance imaging-based visualization of skin deformation in suction experiments confirms the deformation pattern predicted by the multilayer model, showing a consistent decrease in dermal thickness for large probe opening diameters.
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He, Yong, and Sanjeev G. Shroff. "Cyclic stretch downregulates arterial vascular connexin43 protein expression: an ex vivo study." Biomechanics and Modeling in Mechanobiology 9, no. 2 (September 16, 2009): 203–11. http://dx.doi.org/10.1007/s10237-009-0171-4.

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15

Wiemann, M., C. Erlinghagen, J. Bruch, and B. Rehn. "Adsorption of lung surfactant by particles studied in an ex vivo model: effects of quartz and amorphous silica. Untersuchungen zur Adsorption von Lungensurfactant durch Partikel mit einem ex vivo Modell: Effekte von Quarz und amorpher Kieselsäure." Materialwissenschaft und Werkstofftechnik 41, no. 12 (December 2010): 1086–92. http://dx.doi.org/10.1002/mawe.201000713.

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Brockhaus, Katrin, Harutyun Melkonyan, Verena Prokosch, and Solon Thanos. "Erhöhter Intraokulardruck induziert primär zelluläre Reaktionen in den retinalen Kapillaren." Klinische Monatsblätter für Augenheilkunde 234, no. 10 (May 3, 2017): 1266–75. http://dx.doi.org/10.1055/s-0043-105270.

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Zusammenfassung Hintergründe In der Frühdiagnostik des klinischen Glaukoms sind peripapilläre Blutungen fast pathognomonisch für eine Schädigung von Kapillaren. Auch in der Perfusionsdiagnostik herrscht überwiegend die Meinung, dass Perfusionsstörungen und Gefäßveränderungen vorliegen, die im Circulus vitiosus der IOD-Erhöhung (IOD: Intraokulardruck) eine wesentliche Rolle spielen. Damit sind wahrscheinlich die biomechanischen Besonderheiten der Papille sowie die zellulären Reaktionen von Astrozyten, Müller-Zellen, Endothelzellen, Mikroglialzellen und Perizyten assoziiert. Material und Methoden Wir stellen In-vivo- und Ex-vivo-Modelle für IOD-Erhöhungen vor, um die Auflösung unserer Betrachtungsweise bis hin zur zellulären und gar molekularen Reaktion zu erhöhen und Mechanismen der Kapillarzellveränderungen als Folge von IOD-Erhöhung zu verifizieren. Ergebnisse Als Tiermodell diente die kauterisationsbedingte Erhöhung des IOD im Rattenauge. Es wurden 2–3 Episkleralvenen kauterisiert, um den Abflusswiderstand zu erhöhen. Nach Analyse der Netzhäute einige Wochen danach fanden wir eine anormale Expression des ansonsten neuronalspezifischen Moleküls Beta-III-Tubulin in den Kapillarendothelzellen und in den Gefäß- und Kapillarperizyten. Kombinierte immunhistochemische Anfärbungen mit verschiedenen Markern für unterschiedliche Zelltypen bestätigten die Befunde. Die Isolierung von kapillären Endothelzellen und Perizyten aus Rattengehirnen (BMECs) und Retinae (RMECs) und deren In-vitro-Kultivierung unter erhöhten Druckbedingungen in einer eigens konstruierten Druckkammer bestätigten den In-vivo-Befund. Schlussfolgerung Die unerwartete kapilläre Reaktion auf die Erhöhung des IOD in vivo bzw. des Kultivierungsdrucks in vitro kann gegenwärtig als eine frühe Reaktion der Zellen mit Expression anormaler Proteine gedeutet werden. Dieser Befund mag bisherige klinische Beobachtungen erklären, die als peripapilläre Blutungen oder Mikroinfarkte imponieren und wahrscheinlich mit der Optikopathie einhergehen.
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VanEpps, J. Scott, Ricardo Londono, Alejandro Nieponice, and David A. Vorp. "Design and validation of a system to simulate coronary flexure dynamics on arterial segments perfused ex vivo." Biomechanics and Modeling in Mechanobiology 8, no. 1 (February 23, 2008): 57–66. http://dx.doi.org/10.1007/s10237-007-0117-7.

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Dimitrova, Daniela, Biliana Nikolova, Vanya Bogoeva, Bozhil Robev, Iana Tsoneva, Stanislav Dimitrov, and Boris Kadinov. "Do Mistletoe (Viscum album L.) Lectins Influence Isometric Contraction of Non-diseased Human Mesenteric Arteries ex vivo?" International Journal Bioautomation 25, no. 1 (March 2021): 41–52. http://dx.doi.org/10.7546/ijba.2021.25.1.000788.

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Mistletoe (Viscum album L., VA) lectins (MLs) are plant lectins with potent anticancer activity. Although wide use of VA extracts in curing cancer, the effects of purified MLs on human vasculature in term of possible side effect of the lectin has not yet been reported. The present study was aimed to investigate isometric contractions of isolated human mesenteric arteries during MLs application. The contractile response of arteries was studied using Mulvany-Halpern myograph and the isometric contractions under MLs’ treatment were examined in artery segments with either intact endothelium or after endothelium removal. Furthermore, the effect of the lectin was assessed in arterial preparations in basal tension, in arteries precontracted with 42 mM KCl as a depolarizing stimulus or endothelin-1 (ET-1) as a potent receptor-operated agonist of vascular smooth muscle contraction. The results showed that MLs (1 to 100 nM) failed to affect the high K+-induced contractions of both endothelium-intact and endothelium-denuded arteries. The contractions of tissue preparations without endothelium in basal tone or after ET-1 (1 nM) treatment were also not affected by the application of MLs. The observed mild effect of MLs on the contractility of human vasculature may potentially be beneficial with MLs-based anticancer therapy without vascular side effects.
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Joddar, Binata, Rebecca J. G. Shaffer, Rashmeet K. Reen, and Keith J. Gooch. "Arterial pO2 stimulates intimal hyperplasia and serum stimulates inward eutrophic remodeling in porcine saphenous veins cultured ex vivo." Biomechanics and Modeling in Mechanobiology 10, no. 2 (May 30, 2010): 161–75. http://dx.doi.org/10.1007/s10237-010-0224-8.

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Delgado Bermejo, Juan Vicente, María Amparo Martínez Martínez, Guadalupe Rodríguez Galván, Angélika Stemmer, Francisco Javier Navas González, and María Esperanza Camacho Vallejo. "Organization and Management of Conservation Programs and Research in Domestic Animal Genetic Resources." Diversity 11, no. 12 (December 6, 2019): 235. http://dx.doi.org/10.3390/d11120235.

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Creating national committees for domestic animal genetic resources within genetic resource national commissions is recommended to organize in situ and ex situ conservation initiatives. In situ conservation is a high priority because it retains traditional zootechnical contexts and locations to ensure the long-term survival of breeds. In situ actions can be based on subsidies, technical support, structure creation, or trademark definition. Provisional or permanent relocation of breeds may prevent immediate extinction when catastrophes, epizootics, or social conflicts compromise in situ conservation. Ex situ in vivo (animal preservation in rescue or quarantine centers) and in vitro methods (germplasm, tissues/cells, DNA/genes storage) are also potential options. Alert systems must detect emergencies and summon the national committee to implement appropriate procedures. Ex situ coordinated centers must be prepared to permanently or provisionally receive extremely endangered collections. National germplasm banks must maintain sufficient samples of national breeds (duplicated) in their collections to restore extinct populations at levels that guarantee the survival of biodiversity. A conservation management survey, describing national and international governmental and non-governmental structures, was developed. Conservation research initiatives for international domestic animal genetic resources from consortia centralize the efforts of studies on molecular, genomic or geo-evolutionary breed characterization, breed distinction, and functional gene identification. Several consortia also consider ex situ conservation relying on socioeconomic or cultural aspects. The CONBIAND network (Conservation for the Biodiversity of Local Domestic Animals for Sustainable Rural Development) exemplifies conservation efficiency maximization in a low-funding setting, integrating several Latin American consortia with international cooperation where limited human, material, and economic resources are available.
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Pedersen, Kathrine E., Brian L. Fredensborg, Annette B. Jensen, and Nina Cedergreen. "Quantification of the activity of detoxifying enzymes in terrestrial invertebrates: Optimization, evaluation and use of in vitro and ex vivo methods." Methods in Ecology and Evolution 10, no. 5 (March 4, 2019): 726–34. http://dx.doi.org/10.1111/2041-210x.13160.

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Staunton, Jack R., Wilfred Vieira, King Leung Fung, Ross Lake, Alexus Devine, and Kandice Tanner. "Mechanical Properties of the Tumor Stromal Microenvironment Probed In Vitro and Ex Vivo by In Situ-Calibrated Optical Trap-Based Active Microrheology." Cellular and Molecular Bioengineering 9, no. 3 (August 4, 2016): 398–417. http://dx.doi.org/10.1007/s12195-016-0460-9.

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Huang, Chien-Feng Judith, Win-Li Lin, San-Chao Hwang, Ching Yao, Hsu Chang, and Li-Wei Kuo. "Anatomical Phase Extraction (APE) Method: A Novel Method to Correct Detrimental Effects of Tissue-Inhomogeneity in Referenceless MR Thermometry—Preliminary Ex Vivo Investigation." Computational and Mathematical Methods in Medicine 2021 (August 10, 2021): 1–13. http://dx.doi.org/10.1155/2021/5566775.

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Purpose. We present a novel background tissue phase removing method, called anatomical phase extraction (APE), and to investigate the accuracy of temperature estimation and capability of reducing background artifacts compared with the conventional referenceless methods. Methods. Susceptibility variance was acquired by subtracting pretreatment baseline images taken at different locations (nine pretreatment baselines are acquired and called φ 1 to φ 9 ). The susceptibility phase data φ S was obtained using the Wiener deconvolution algorithm. The background phase data φ T was isolated by subtracting φ S from the whole phase data. Finally, φ T was subtracted from the whole phase data before applying the referenceless method. As a proof of concept, the proposed APE method was performed on ex vivo pork tenderloin and compared with other two referenceless temperature estimation approaches, including reweighted ℓ 1 referenceless (RW- ℓ 1) and ℓ 2 referenceless methods. The proposed APE method was performed with four different baselines combination, namely, ( φ 1 , φ 5 , φ 2 , φ 4 ), ( φ 3 , φ 5 , φ 2 , φ 6 ), ( φ 7 , φ 5 , φ 8 , φ 4 ), and ( φ 9 , φ 5 , φ 8 , φ 6 ), and called APE experiment 1 to 4, respectively. The multibaseline method was used as a standard reference. The mean absolute error (MAE) and two-sample t -test analysis in temperature estimation of three regions of interest (ROI) between the multibaseline method and the other three methods, i.e., APE, RW- ℓ 1, and ℓ 2, were calculated and compared. Results. Our results show that the mean temperature errors of the APE method-experiment 1, APE method-experiment 2, APE method-experiment 3, APE method-experiment 4, and RW- ℓ 1 and ℓ 2 referenceless method are 1.02°C, 1.04°C, 1.00°C, 1.00°C, 4.75°C, and 13.65°C, respectively. The MAEs of the RW- ℓ 1 and ℓ 2 referenceless methods were higher than that of APE method. The APE method showed no significant difference ( p > 0.05 ), compared with the multibaseline method. Conclusion. The present work demonstrates the use of the APE method on referenceless MR thermometry to improve the accuracy of temperature estimation during MRI guided high-intensity focused ultrasound for ablation treatment.
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Yang, Sungwook, Joseph N. Martel, Louis A. Lobes, and Cameron N. Riviere. "Techniques for robot-aided intraocular surgery using monocular vision." International Journal of Robotics Research 37, no. 8 (July 2018): 931–52. http://dx.doi.org/10.1177/0278364918778352.

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This paper presents techniques for robot-aided intraocular surgery using monocular vision in order to overcome erroneous stereo reconstruction in an intact eye. We propose a new retinal surface estimation method based on a structured-light approach. A handheld robot known as the Micron enables automatic scanning of a laser probe, creating projected beam patterns on the retinal surface. Geometric analysis of the patterns then allows planar reconstruction of the surface. To realize automated surgery in an intact eye, monocular hybrid visual servoing is accomplished through a scheme that incorporates surface reconstruction and partitioned visual servoing. We investigate the sensitivity of the estimation method according to relevant parameters and also evaluate its performance in both dry and wet conditions. The approach is validated through experiments for automated laser photocoagulation in a realistic eye phantom in vitro. Finally, we present the first demonstration of automated intraocular laser surgery in porcine eyes ex vivo.
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Bowley, Sarah C., Pierre Comizzoli, Kevin A. Lindell, David J. Matsas, and Eugene C. White. "Genetic Cryopreservation of Rare Breeds of Domesticated North American Livestock: Smithsonian & SVF Biodiversity Preservation Project." Diversity 11, no. 10 (October 18, 2019): 198. http://dx.doi.org/10.3390/d11100198.

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Modern agriculture has responded to the growing pressure for animal-protein consumption in the global human population by selecting for specific production traits, which, over the last fifty years, has resulted in a loss of genetic diversity. Most rare and endangered breeds of livestock have not experienced the same selection pressures for production and therefore may contain useful genetic traits not found within modern breeds. In an effort to maintain biodiversity of livestock breeds, the SVF Foundation, a non-profit organization founded to preserve the genetic diversity of food and fiber livestock, has established an ex situ repository of genetic material from endangered North American cattle, sheep, and goats. This genetic material includes in vivo and in vitro produced embryos, semen, fibroblasts, serum, and whole blood DNA cards. The majority of samples in the SVF repository are cryopreserved, creating a genome resource bank for future use. Through the Smithsonian and SVF Biodiversity Preservation Project, this repository will be maintained at the Smithsonian’s Front Royal, VA, facility. This effort represents an excellent model for understanding and sustaining the genetic diversity of rare breeds in the US and in other countries.
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Grassi, Lorenzo, Sami P. Väänänen, Matti Ristinmaa, Jukka S. Jurvelin, and Hanna Isaksson. "Prediction of femoral strength using 3D finite element models reconstructed from DXA images: validation against experiments." Biomechanics and Modeling in Mechanobiology 16, no. 3 (December 21, 2016): 989–1000. http://dx.doi.org/10.1007/s10237-016-0866-2.

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Abstract Computed tomography (CT)-based finite element (FE) models may improve the current osteoporosis diagnostics and prediction of fracture risk by providing an estimate for femoral strength. However, the need for a CT scan, as opposed to the conventional use of dual-energy X-ray absorptiometry (DXA) for osteoporosis diagnostics, is considered a major obstacle. The 3D shape and bone mineral density (BMD) distribution of a femur can be reconstructed using a statistical shape and appearance model (SSAM) and the DXA image of the femur. Then, the reconstructed shape and BMD could be used to build FE models to predict bone strength. Since high accuracy is needed in all steps of the analysis, this study aimed at evaluating the ability of a 3D FE model built from one 2D DXA image to predict the strains and fracture load of human femora. Three cadaver femora were retrieved, for which experimental measurements from ex vivo mechanical tests were available. FE models were built using the SSAM-based reconstructions: using only the SSAM-reconstructed shape, only the SSAM-reconstructed BMD distribution, and the full SSAM-based reconstruction (including both shape and BMD distribution). When compared with experimental data, the SSAM-based models predicted accurately principal strains (coefficient of determination >0.83, normalized root-mean-square error <16%) and femoral strength (standard error of the estimate 1215 N). These results were only slightly inferior to those obtained with CT-based FE models, but with the considerable advantage of the models being built from DXA images. In summary, the results support the feasibility of SSAM-based models as a practical tool to introduce FE-based bone strength estimation in the current fracture risk diagnostics.
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Tackenberg, Michael C., and Jacob J. Hughey. "The risks of using the chi-square periodogram to estimate the period of biological rhythms." PLOS Computational Biology 17, no. 1 (January 6, 2021): e1008567. http://dx.doi.org/10.1371/journal.pcbi.1008567.

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The chi-square periodogram (CSP), developed over 40 years ago, continues to be one of the most popular methods to estimate the period of circadian (circa 24-h) rhythms. Previous work has indicated the CSP is sometimes less accurate than other methods, but understanding of why and under what conditions remains incomplete. Using simulated rhythmic time-courses, we found that the CSP is prone to underestimating the period in a manner that depends on the true period and the length of the time-course. This underestimation bias is most severe in short time-courses (e.g., 3 days), but is also visible in longer simulated time-courses (e.g., 12 days) and in experimental time-courses of mouse wheel-running and ex vivo bioluminescence. We traced the source of the bias to discontinuities in the periodogram that are related to the number of time-points the CSP uses to calculate the observed variance for a given test period. By revising the calculation to avoid discontinuities, we developed a new version, the greedy CSP, that shows reduced bias and improved accuracy. Nonetheless, even the greedy CSP tended to be less accurate on our simulated time-courses than an alternative method, namely the Lomb-Scargle periodogram. Thus, although our study describes a major improvement to a classic method, it also suggests that users should generally avoid the CSP when estimating the period of biological rhythms.
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Luo, Yifu, Chris S. Bresee, John W. Rudnicki, and Mitra J. Z. Hartmann. "Constraints on the deformation of the vibrissa within the follicle." PLOS Computational Biology 17, no. 4 (April 1, 2021): e1007887. http://dx.doi.org/10.1371/journal.pcbi.1007887.

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Nearly all mammals have a vibrissal system specialized for tactile sensation, composed of whiskers growing from sensor-rich follicles in the skin. When a whisker deflects against an object, it deforms within the follicle and exerts forces on the mechanoreceptors inside. In addition, during active whisking behavior, muscle contractions around the follicle and increases in blood pressure in the ring sinus will affect the whisker deformation profile. To date, however, it is not yet possible to experimentally measure how the whisker deforms in an intact follicle or its effects on different groups of mechanoreceptors. The present study develops a novel model to predict vibrissal deformation within the follicle sinus complex. The model is based on experimental results from a previous ex vivo study on whisker deformation within the follicle, and on a new histological analysis of follicle tissue. It is then used to simulate whisker deformation within the follicle during passive touch and active whisking. Results suggest that the most likely whisker deformation profile is “S-shaped,” crossing the midline of the follicle right below the ring sinus. Simulations of active whisking indicate that an increase in overall muscle stiffness, an increase in the ratio between deep and superficial intrinsic muscle stiffness, and an increase in sinus blood pressure will all enhance tactile sensitivity. Finally, we discuss how the deformation profiles might map to the responses of primary afferents of each mechanoreceptor type. The mechanical model presented in this study is an important first step in simulating mechanical interactions within whisker follicles.
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Veith, Irina, Arianna Mencattini, Valentin Picant, Marco Serra, Marine Leclerc, Maria Colomba Comes, Fathia Mami-Chouaib, et al. "Apoptosis mapping in space and time of 3D tumor ecosystems reveals transmissibility of cytotoxic cancer death." PLOS Computational Biology 17, no. 3 (March 30, 2021): e1008870. http://dx.doi.org/10.1371/journal.pcbi.1008870.

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The emerging tumor-on-chip (ToC) approaches allow to address biomedical questions out of reach with classical cell culture techniques: in biomimetic 3D hydrogels they partially reconstitute ex vivo the complexity of the tumor microenvironment and the cellular dynamics involving multiple cell types (cancer cells, immune cells, fibroblasts, etc.). However, a clear bottleneck is the extraction and interpretation of the rich biological information contained, sometime hidden, in the cell co-culture videos. In this work, we develop and apply novel video analysis algorithms to automatically measure the cytotoxic effects on human cancer cells (lung and breast) induced either by doxorubicin chemotherapy drug or by autologous tumor-infiltrating cytotoxic T lymphocytes (CTL). A live fluorescent dye (red) is used to selectively pre-stain the cancer cells before co-cultures and a live fluorescent reporter for caspase activity (green) is used to monitor apoptotic cell death. The here described open-source computational method, named STAMP (spatiotemporal apoptosis mapper), extracts the temporal kinetics and the spatial maps of cancer death, by localizing and tracking cancer cells in the red channel, and by counting the red to green transition signals, over 2–3 days. The robustness and versatility of the method is demonstrated by its application to different cell models and co-culture combinations. Noteworthy, this approach reveals the strong contribution of primary cancer-associated fibroblasts (CAFs) to breast cancer chemo-resistance, proving to be a powerful strategy to investigate intercellular cross-talks and drug resistance mechanisms. Moreover, we defined a new parameter, the ‘potential of death induction’, which is computed in time and in space to quantify the impact of dying cells on neighbor cells. We found that, contrary to natural death, cancer death induced by chemotherapy or by CTL is transmissible, in that it promotes the death of nearby cancer cells, suggesting the release of diffusible factors which amplify the initial cytotoxic stimulus.
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Goff, Lydia, Rhonda St. Croix, Jenny W. Jing, Dario Ferri, Mithusa Sivanathan, Chelsea Harris, Florence Pelletier, et al. "C-CASE 2022: Competence to Excellence01. The Queen Bee phenomenon in Canadian surgical subspecialties: an evaluation of gender biases in the resident training environment02. Barriers to surgical peer coaching — What have we learned, and where do we go from here?03. Shared decision-making and evidence-based medicine: Pivotal or trivial to patient care in orthopedic trauma?04. Immersive virtual reality and cadaveric bone are equally effective in skeletal anatomy education: a randomized crossover noninferiority trial05. Development of simulators for decentralized simulation-based education IO training using design thinking and Delphi — a novel approach06. The impact of feedback on laparoscopic skills for surgical residents during COVID-1907. The role of collaborative feedback and remote practice in the acquisition of suturing skills by medical students at Université de Montréal08. Efficacy testing of an affordable and realistic small bowel simulator for hand-sewn anastomosis09. The LASER rating scale: a new teaching tool in otolaryngology10. Virtual patient case simulations: their role in undergraduate and postgraduate surgical training11. Evaluating the effectiveness of video-assisted informed consent in surgery: a systematic review12. Communication patterns in the cardiac surgery operating room are affected by task difficulty: a simulation model13. Improving adherence to postcall departure guidelines in orthopedics: a quality-improvement initiative14. Increasing familiarity among team members helps to reduce laparoscopic procedure time15. The effectiveness of a self-directed online learning module on trainee knowledge and confidence during plastic surgery clinical rotations16. Implementing an orientation handbook before a surgical rotation in urology17. An examination of equity-related experiences of surgical trainees at academic centres across Ontario: design of a targeted needs assessment18. Viewing differences between experts and trainees: implication for surgical education19. Assessment of medical student exposure to and satisfaction with surgical subspecialty education20. Assessment of student exposure to climate impacts of surgical personal protective equipment in the undergraduate medical curriculum21. Virtual reality simulation for the middle cranial fossa approach — a face, content and construct validation study22. Evaluating the Canadian Orthopaedic Surgery Medical Education Course (COSMEC)23. Subpial resection in a novel ex vivo calf brain epilepsy simulation model24. Effectiveness of the Eyesi augmented reality simulator for ophthalmology trainees: a systematic review and meta-analysis25. Learning beyond the objectives: an evidence-based analysis of AI-selected competencies in surgical simulation training26. Virtual compared with in-person surgical grand rounds: participants’ perceptions, preferences and directions for the future27. Quality of narrative feedback for entrustable professional activities assessed in the operating room: analysis of 4. years of assessments in the surgical foundations curriculum at Queen’s University28. SimOscopy: an accessible 3D-printed and laser-cut laparoscopic surgical simulator developed for a mobile device29. A debriefing tool to acquire nontechnical skills in trauma courses30. Capacity building using a hub-and-spokes model to produce customizable simulators for surgical education31. Exploring skin tone diversity in a plastic surgery resident education curriculum32. Video-based assessments of thoracic surgery trainees’ operative skills as adjuncts in competency-based medical education33. How do you feel? An examination of team leaders’ and members’ emotions in surgical simulations34. Comparing the efficacy of a real-time intelligent coaching system to human expert instruction in surgical technical skills training: randomized controlled trial35. Empowering women to pursue surgery: launching a pilot gender-congruent mentorship program for medical students36. Affective and cognitive responses to a virtual reality spine simulator37. Immersive virtual reality for patient-specific preoperative planning: a systematic review38. The categorization of surgical problems by junior and senior medical students39. The application of microlearning modules in surgical education to enhance procedural skills and surgical training40. Authorship gender disparity and trends in female authorship in 5 high-impact orthopedic journals from 2002 to 202241. The landscape of Canadian academic surgery: analysis of gender representation, academic rank, and research productivity." Canadian Journal of Surgery 65, no. 6 Suppl 1 (November 24, 2022): S19—S32. http://dx.doi.org/10.1503/cjs.014622.

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Huynh, C., E. Clement, D. DeGirolamo, A. Kleiman, R. Ralph-Edwards, L. Streith, J. Bogach, et al. "Canadian Surgery Forum 201901. The future of general surgery training: a Canadian resident nationwide Delphi consensus statement02. Traumatized: Can mindfulness lead to improved mental health outcomes after multisystem trauma?03. Operating room availability for general surgery in 2007 versus 2017 at a regional hospital in BC04. Perceptions and barriers to Gastrografin protocol implementation05. Resident opinions and educational experience of a mixed night-float system for general surgery resident call06. A scoping review of best management for hepato-pancreatobiliary trauma07. Simultaneous versus staged resection for synchronous colorectal liver metastases: a population-based cohort study08. Weight loss following hepatopancreatobiliary surgery. How much is too much?09. Uptake and patient outcomes of laparoscopic liver resection for colon cancer liver metastases: a population-based analysis10. Simultaneous resection of colorectal cancer with synchronous liver metastases: a survey-based analysis11. When is it safe to start VTE prophylaxis after blunt solid organ injury? A prospective study from a level I trauma centre12. Undertriaged trauma patients: Who are we missing?13. Trauma team activation at a level I trauma centre: time of day matters14. The diagnostic dilemma of shotgun injuries15. Evaluating the efficacy of self-study videos for the surgery clerkship rotation: an innovative project in undergraduate surgical education16. Systematic review and meta-analysis: preoperative anti-TNF therapy does not increase the risk of postoperative complications in patients with inflammatory bowel disease undergoing elective surgery17. Simulation platforms to assess laparoscopic suturing skills: a scoping review18. Cost analysis of simultaneous versus staged resection of colorectal cancer liver metastases: a population-based study19. Complementary and alternative medicine use among general surgery patients in Nova Scotia20. General surgery in Canada: current scope of practice and future needs21. Impact of dedicated operating time on access to surgical care in an acute care surgery model22. Adolescent appendicitis management and outcomes: comparison study between adult and pediatric institutions23. A systematic review of behavioural interventions to improve opioid prescribing after surgery24. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in trauma: a gap analysis of the Edmonton Zone Trauma Registry25. Learning by holographic anatomic models for surgical education26. The nature of learning from trauma team simulation27. Comparing reversing half-hitch alternating postsurgical knots and square knots for closure of enterotomy in a simulated deep body cavity: a randomized controlled trial28. Propagating the “SEAD”: exploring the value of an overnight call shift in the Surgical Exploration and Discovery Program29. Comparing 2 approaches to residency application file review30. A Canadian experience with posterior retroperitoneoscopic adrenalectomy31. A cost-efficient, realistic breast phantom for oncoplastic breast surgery training32. Impact of patient frailty on morbidity and mortality after common emergency general surgery operations33. Preventing opioid prescription after major surgery: a scoping review of the literature on opioid-free analgesia34. Correct usage of propensity score methodology in contemporary high-impact surgical literature35. Responsible blood compatibility testing for appendectomy: practice assessment at a single Canadian academic centre36. What patient factors are associated with participation in a provincial colorectal cancer screening program?37. Missed appendix tumours owing to nonoperative management for appendicitis38. Operative delay increases morbidity and mortality in emergency general surgery patients: a study of multiple EGS services within a single city39. Withdrawn40. Improved disease-free survival after prehabilitation for colorectal cancer surgery41. Development of a conceptual framework of recovery after abdominal surgery42. Comparison of Dor and Nissen fundoplication following laparoscopic paraesophageal hernia repair43. A systematic review and summary of clinical practice guidelines on the periprocedural management of patients on antithrombotic medications undergoing gastroenterological endoscopy44. Impact of socioeconomic status on postoperative complications following Whipple procedure for pancreatic ductal adenocarcinoma45. Clinical outcomes of high-risk breast lesions and breast cancer patients treated with total mastectomy and immediate reconstruction46. My On Call (MOC) Pager App: practising and assessing safe clinical decision-making47. Comprehensive complication index for major abdominal surgeries: an external validation using the American College of Surgeons’ National Surgical Quality Improvement Program (ACS NSQIP)48. The impact of surgeon experience on script concordance test scoring49. Decay of competence with extended research absences during postgraduate residency training: a scoping review50. Long-term outcomes of elderly patients managed nonoperatively for choledocholithiasis51. Predictors of mortality and cost among surgical patients admitted to hospital and requiring rapid response team activation52. Sex-based disparities in the hourly earnings of surgeons in Ontario’s fee-for-service system53. Outcomes of intestinal ischemia among patients undergoing cardiac surgery54. Factors influencing resident teaching evaluations: the relationship between resident interest in teaching, career plan, training level and their performance in teaching junior learners55. Validating a uniform system for measuring disease severity in acute colonic diverticulitis56. Active negative pressure peritoneal therapy and C-reactive protein (CRP) levels after abbreviated laparotomy for abdominal trauma or intraabdominal sepsis: the validity of serum and peritoneal CRP in measuring outcomes in critically ill patients57. Intraoperative use of indocyanine green fluorescence in emergency general surgery: a systematic review58. Is it safe? Nonoperaive management of blunt splenic injuries in geriatric trauma patients59. Bladder injury from laparoscopic appendicectomy: a multicentre experience over 5 years60. Perioperative cardiac investigations for chest pain after parathyroidectomy rarely yield a cardiac diagnosis61. Entero-hepatic axis injury following hemorrhagic shock: a role for uric acid62. Loss of functional independence after emergency abdominal surgery in older patients: a prospective cohort study63. Association between use of nonsteroidal antiinflammatory drugs, diuretics or angiotensin converting enzyme inhibitor/receptor blockers after major surgery and acute kidney injury: a nested, population-based case–control study64. Timing of CT for adhesive small bowel obstructions (SBO)65. The ABDO (Acute Biliary Disease Optimization) Study: improving the management of biliary diseases in emergency general surgery66. Rates and predictors of advanced biliary imaging and interventions in acute care surgery: a quality improvement study67. The use of early warning scores in patients undergoing emergency general surgery: a systematic review68. Does primary closure versus resection and anastomosis in patients with hollow viscus injury affect 30-day mortality?69. Impact of sarcopenia on morbidity and mortality after Whipple procedure for pancreatic ductal adenocarcinoma70. Mind the speaker gap: a cross-specialty analysis of the representation of women at surgical meetings in 5 different geographic regions71. Immediate breast reconstruction in locally advanced breast cancer: Is it safe?72. An administrative review of the incidence of adverse events involving electrocautery73. If you don’t document it, did it really happen? A review of the documentation of informed consent in laparoscopic cholecystectomy74. Can an online module help medical students gain confidence and proficiency in writing orders?75. The influence of undergraduate medical education anatomy exposure on choice of surgical specialty: a national survey76. Association between patient engagement and surgical outcomes: a pilot study77. Guidelines on the intraoperative transfusion of red blood cells: a systematic review78. Cancer is common in missed appendicitis: a retrospective cohort study79. Everyone is awesome: analyzing letters of reference in a general surgery residency selection process80. Evaluating the true additional costs of general surgery complications using a propensity score weighted model81. Deriving literature-based benchmarks for surgical complications from national databases in high-income countries: a systematic review on pancreatectomy outcomes82. The impact of distance on postoperative follow-up in pediatric general surgery patients: a retrospective review83. Water-soluble contrast in adhesive small bowel obstruction management: a Canadian centre’s experience84. Recognizing predatory journals in general surgery and their common violations85. Prophylactic negative pressure wound therapy for closed laparotomy incisions: a meta-analysis of randomized controlled trials86. Choosing Wisely Canada: 2019 general surgery recommendations87. Content-specific resident teaching can improve medical student learning outcomes on certifying examinations88. Transition to practice: preparedness for independent practice in general surgery graduates89. CAGS Exam 2.0: maximizing the potential for teaching and learning90. Resident attitudes toward the introduction of synoptic operative reporting for appendectomy and cholecystectomy91. Determining the individual, hospital and environmental cost of unnecessary laboratory investigations for patients admitted to general surgery services at an academic centre92. Gender-based compensation disparity among general surgeons in British Columbia93. Transgastric robotic resection for gastrointestinal stromal tumours of the stomach94. Recurrent gallstone ileus after laparoscopic-assisted enterolithotomy treated with totally laparoscopic enterolithotomy01. Predictors and outcomes among patients requiring salvage APR for the treatment of squamous cell carcinoma of the anus: a population-based study02. Short-course radiotherapy with perioperative systemic chemotherapy for patients with rectal cancer and synchronous resectable liver metastases: a single-centre Canadian experience03. Compliance with preoperative elements of the American Society of Colon and Rectal Surgeons rectal cancer surgery checklist improves pathologic and postoperative outcomes04. Clinical predictors of pathologic complete response following neoadjuvant chemoradiation therapy for rectal cancer: a systematic review and meta-analysis05. Rejected06. The impact of laparoscopic technique on the rate of perineal hernia after abdominoperineal resection of the rectum07. An assessment of the current perioperative practice, barriers and predictors for utilization of enhanced recovery after surgery protocols: a provincial survey08. Regional variation in the utilization of laparoscopy for the treatment of rectal cancer: the importance of fellowship training sites09. Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy: a systematic review and meta-analysis10. The relation between the gut microbiota and anastomotic leak in patients with colorectal cancer: a preliminary feasibility study11. Optimizing discharge decision-making in colorectal surgery: an audit of discharge practices in a newly implemented enhanced recovery pathway12. Trends in colectomy for colorectal neoplasms in ulcerative colitis (UC) patients over 2 decades: a National Inpatient Sample database analysis13. Spin in minimally invasive transanal total mesorectal excision articles (TaTME): an assessment of the current literature14. Venous thromboembolism (VTE) in colon cancer: a population-based cohort study of VTE rates following surgery and during adjuvant chemotherapy15. Robotic-assisted lateral lymph node dissection for rectal neuroendocrine tumor16. Loop ileostomy and colonic lavage as an alternative to colectomy for fulminant Clostridium difficile colitis17. Recurrent diverticulitis: Is it all in the family?18. Le traitement des fistules entérocutanées complexes : expérience du Centre hospitalier de l’Université de Montréal (CHUM)19. A North American single-blinded pilot randomized controlled trial for outpatient nonantibiotic management of acute uncomplicated diverticulitis (MUD TRIAL): feasibility and lessons learned20. Treatment failure after conservative management of acute diverticulitis: a nationwide readmission database analysis21. Impact of immunosuppression on mortality and major morbidity following sigmoid colectomy for diverticulitis: a propensity-score weighted analysis of the National Inpatient Sample22. Presentation and survival in colorectal cancer under 50 years of age: a systematic review and meta-analysis23. Genetics of postoperative recurrence of Crohn’s disease: a systematic review and meta-analysis24. Improving the identification and treatment of preoperative anemia in patients undergoing elective bowel resection25. Impact of postoperative complications on quality of life after colorectal surgery26. Colon cancer survival by subsite: a retrospective analysis of the National Cancer Database27. A second opinion for T1 colorectal cancer pathology reports results in frequent changes to clinical management28. Effects of the quadratus lumborum block regional anesthesia on postoperative pain after colorectal resection: a double-blind randomized clinical trial29. Safety of a short-stay postoperative unit for the early discharge of patients undergoing a laparosocpic right hemicolectomy30. What is the optimal bowel preparation to reduce surgical site infection in Crohn disease?31. TaTME surgery and the learning curve: our early experience32. Watch-and-wait experience in patients with rectal cancer: results in selected patients at a high-volume centre01. Automatic referral of suspicious findings detected on thoracic CT scan decreases delays in care without compromising referral quality02. Variation in receipt of therapy and survival with provider volume in noncurative esophagogastric cancer: a population-based analysis03. What makes patients high risk for lobectomy in the era of minimally invasive lobectomy?04. The value proposition of minimally invasive esophagectomy: a community hospital perspective05. Deviation from treatment plan in patients with potentially curable esophageal carcinoma06. Implementation of a standardized minimal opioid prescription for post-thoracic surgery patients is feasible and provides adequate pain control07. Sentinel node navigation surgery using indocyanine green in lung cancer: a systematic review and meta-analysis08. Surgical outcomes with trimodality neoadjuvant versus adjuvant therapy for esophageal cancer: results of the QUINTETT randomized trial09. Enhanced invasive mediastinal staging in an academic thoracic surgical unit by employing a shared accountability model for quality improvement10. Evaluation and harmonization of international database elements for adverse events monitoring following thoracic surgery: the pursuit of a common language11. Endobronchial ultrasound staging of operable non–small cell lung carcinoma: triple-negative lymph nodes may not require routine biopsy12. Wait times in the management of non-small cell lung cancer before, during and after regionalization of lung cancer care: a high-resolution analysis13. Wearable technology for preconditioning before thoracic surgery: a feasibility study14. Impact of carbohydrate-loading enhanced recovery after surgery protocol on adverse cardiopulmonary events in a thoracic surgery population15. Heat production during pulmonary artery sealing with energy vessel-sealing devices in a porcine model16. Who can afford to wait? The effect of wait times on survival in lung cancer patients: clinical predictors of poor outcomes17. Impact of the Integrated Comprehensive Care Program after thoracic surgery: a propensity score matched study18. Incidence, severity and risk of postoperative pulmonary complications in patients undergoing pulmonary resection for cancer19. Evaluation of the limits of use of a thoracoscopic lung palpation device to identify artificial tumour nodules in ex-vivo tissue20. Personalized surgical management of esophagogastric junction cancers21. Validity of a model to predict the risk of atrial fibrillation after thoracic surgery22. Severe symptoms persist for up to 1 year after diagnosis of stage I–III lung cancer: an analysis of province-wide patient-reported outcomes23. Do postoperative infectious adverse events influence cancer recurrence and survival after surgical resection of esophagogastric cancers? Experience from a Canadian university centre24. Utilization, safety and efficacy of hybrid esophagectomy on a population level25. Endoscopic submucosal dissection for upper gastrointestinal neoplasia: lessons learned from a high-volume North American centre26. Long-term quality of life after esophagectomy27. Early and late outcomes after surgery for pT4 NSCLC reclassified by AJCC 8th edition criteria28. Early results on the learning curve for subxiphoid video-assisted thoracoscopic lobectomy29. Should adjuvant therapy be offered for patients undergoing esophagectomy after neoadjuvant CROSS protocol for esophageal cancer? A multicentre cohort study30. Outcomes of patients discharged home with a chest tube following anatomic lung resection: a multicentre cohort study01. Management of cancer-associated intestinal obstruction in the final year of life02. Evaluating the prognostic significance of lymphovascular invasion in stage II and III colon cancer03. A matched case–control study on real-time electromagnetic navigation for breast-conserving surgery using NaviKnife04. Gaps in the management of depression symptom screening following cancer diagnosis: a population-based analysis of prospective symptom screening05. Patterns of symptom burden in neuroendocrine tumours: a population-based analysis of patient-reported outcomes06. Outcomes of salvage surgery for anal canal squamous cell carcinoma: a systematic review and meta-analysis07. Expression of the Plk4 inhibitor FAM46C predicts better survival following resection of gastric adenocarcinoma08. Current treatment strategies and patterns of recurrence in locally advanced colon cancer09. A 5-year retrospective review of outcomes after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in a provincial peritoneal malignancy program10. Withdrawn11. Geographic disparities in care and outcomes for noncurative pancreatic adenocarcinoma: a population-based study12. How often is implant-based breast reconstruction following postmastectomy radiation unsuccessful?13. Comparison of partial mastectomy specimen volume and tumour volume following neoadjuvant chemotherapy in breast cancer14. Two-year experience with hookwire localized clipped node and sentinel node as alternative to targeted axillary dissection in a regional centre15. Opioid use among cancer patients undergoing surgery and their associated risk of readmissions and emergency department visits in the 1-year postsurgical period16. Preliminary results of a pilot randomized controlled trial comparing axillary reverse mapping with standard axillary surgery in women with operable breast cancer17. Complementary and alternative medicine among general surgery patients in Nova Scotia18. Improving wait times and patient experience through implementation of a provincial expedited diagnostic pathway for BI-RADS 5 breast lesions19. Population-based regional recurrence patterns in Merkel cell carcinoma: a 15-year review20. Survival and health care cost benefits of high-volume care in the noncurative management of pancreatic adenocarcinoma: a population-based analysis21. Trends in the use of sentinel node biopsy after neoadjuvant chemotherapy in the United States22. Predictors of grossly incomplete resection in primary retroperitoneal sarcoma (RPS)23. Mastectomy versus breast conservation therapy: an examination of how individual, clinicopathologic and physician factors influence decision making24. Immunophenotyping postoperative myeloid-derived suppressor cells in cancer surgery patients25. Adherence to sentinel lymph node biopsy guidelines in the management of cutaneous melanoma in the province of British Columbia26. Breast cancer with supraclavicular and internal mammary node metastases: therapeutic options27. Textbook outcomes and survival in patients with gastric cancer: an analysis of the population registry of esophageal and stomach tumours of Ontario (PRESTO)28. Withdrawn29. Symptomatic bowel complications in patients with metastatic cancer: comparison of surgical versus medical outcomes and development of a prediction model for successful surgical palliation30. Rejected31. Gastric cancer biopsies show distinct biomarker profiles compared with normal gastric mucosa in Canadian patients32. Withdrawn01. Management of high patient-reported pain scores in noncurative pancreatic adenocarcinoma: a population-based analysis02. Outcomes of liver donors with a future liver remnant less than or equal to 30%: a matched-cohort study03. The applicability of intraoperative fluorescent imaging with indocyanine green in hepatic resection for malignancy: a systematic review and meta-analysis04. Impact of adjuvant chemotherapy completion on outcomes following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma05. Primary hepatic acinar cell carcinoma06. Laparoscopic distal pancreatectomy provides equivalent oncologic outcomes for pancreatic ductal adenocarcinoma07. Passive versus active intraabdominal drainage following pancreatic resection: Does a superior drainage system exist? A systematic review and meta-analysis08. Low yield of preoperative MRCP and ERCP in the management of low-intermediate suspicion choledocholithiasis09. Pancreatic cancer resection rates and survival in the United States and Canada10. Prognostic value of immune heterogeneity in colorectal cancer liver metastases11. Impact of intraoperative hypovolemic phlebotomy on blood loss and perioperative transfusion in patients undergoing hepatectomy for cancer12. Prediction of postoperative pancreatic fistula following pancreatectomy: a systematic review of clinical tools13. The impact of preoperative frailty in liver resection: an analysis of the American College of Surgeons’ National Surgical Quality Improvement Program (ACS NSQIP)14. Topical agents as adjuncts in pancreatic surgery for prevention of postoperative pancreatic fistula: a systematic review and meta-analysis15. Phlebotomy resulting in controlled hypovolemia to prevent blood loss in major hepatic resections (PRICE-1): a feasibility randomized controlled trial16. Pylorus-preserving versus classic pancreaticoduodenectomy: a single-centre retrospective review of total lymph node yield17. An audit and evaluation of appropriateness of intraoperative allogenic red blood cell transfusion in liver surgery: application of 3 decision rules18. A comparison of lymph node ratio with AJCC lymph node status for survival after Whipple resection for pancreatic adenocarcinoma19. Duodenopancréatectomie céphalique (intervention de Whipple) par voie laparoscopique pure20. Use of the Molecular Adsorbent Recirculating System (MARS) in acute liver failure: a multicentre experience21. Barriers to adjuvant chemotherapy after resection for pancreatic cancer22. Comparison of primary and metastatic pancreatic cancer by clinical and genomic features23. Factors associated with invasion and postoperative overall survival in resected IPMN01. Incisional hernia repair surgery improves patient-reported outcomes02. Prospective study of single-stage repair of contaminated hernias with the novel use of calcium sulfate antibiotic beads in conjunction with biologic porcine submucosa tissue matrix03. e-TEP transversus abdominus release04. Umbilical hernias05. Review of 1061 femoral hernias done at the Shouldice Hospital over a period of 6 years01. Metabolic outcomes after bariatric surgery for a provincial Indigenous population02. Outcomes of sleeve gastrectomy performed in a regional hospital03. A longitudinal analysis of wait times in a publicly funded, regionalized bariatric care system04. Concurrent laparoscopic ventral hernia repair with bariatric surgery: a propensity-matched analysis05. Outcomes from explantation of laparoscopic adjustable gastric band: experience from a Canadian bariatric centre of excellence06. Development of consensus-derived quality indicators for laparoscopic sleeve gastrectomy07. Conversion of sleeve gastrectomy to laparoscopic Roux-en-Y gastric bypass in intestinal nonrotation08. The utility of routine preoperative upper gastrointestinal series for laparoscopic sleeve gastrectomy09. Body image concerns, depression, suicidality and psychopharmacological changes in postoperative bariatric surgery patients: a mixed-methods study10. Technical factors associated with early sleeve stenosis after sleeve gastrectomy: an analysis of the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database11. Analysis of complication and readmission rates after laparoscopic sleeve gastrectomy at a single bariatric surgery centre: a retrospective NSQIP study12. Management of common bile duct stones in patients after Roux-en-Y gastric bypass: a systematic review13. Improvement and resolution of urinary incontinence after bariatric surgery: a systematic review and meta-analysis14. Bridging interventions for weight loss prior to bariatric surgery in patients with superobesity: a systematic review and meta-analysis15. Secondary and tertiary learning curves in bariatric surgery16. Achalasia following laparoscopic sleeve gastrectomy: a case report17. Multidisciplinary approach to halving length of stay after bariatric surgery18. Prospective analysis of staple line haemostatic materials in stapled bariatric surgery19. Barriers and facilitators to managing patients with class II and III obesity in primary care: a qualitative study20. The Edmonton Obesity Staging System predicts risk of postoperative complications and mortality following bariatric surgery21. The impact of attention-deficit/hyperactivity disorder on bariatric surgery outcomes: systematic review and meta-analysis22. The effect of bariatric surgery on migraines: a systematic review and meta-analysis23. A population-based matched cohort study of mortality after bariatric surgery24. Safety and outcomes of bariatric surgery performed at an ambulatory site associated with a tertiary care hospital in Canada25. Race and sex predict adverse outcomes following bariatric surgery: a propensity-matched MBSAQIP analysis26. A survey of primary care physician referral to bariatric surgery: access, perceptions and barriers." Canadian Journal of Surgery 62, no. 4 Suppl 2 (August 2019): S89—S169. http://dx.doi.org/10.1503/cjs.011719.

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Fayez, R., A. AlMuntashery, G. Bodie, A. Almamar, R. S. Gill, I. Raîche, C. L. Mueller, et al. "Canadian Surgery Forum1 Is laparoscopic sleeve gastrectomy a reasonable stand-alone procedure for super morbidly obese patients?2 Postoperative monitoring requirements of patients with obstructive sleep apnea undergoing bariatric surgery3 Role of relaparoscopy in the diagnosis and treatment of bariatric complications in the early postoperative period4 Changes of active and total ghrelin, GLP-1 and PYY following restrictive bariatric surgery and their impact on satiety: comparison of sleeve gastrectomy and adjustable gastric banding5 Prioritization and willingness to pay for bariatric surgery: the patient perspective6 Ventral hernia at the time of laparoscopic gastric bypass surgery: Should it be repaired?7 Linear stapled gastrojejunostomy with transverse handsewn enterotomy closure significantly reduces strictures for laparoscopic Roux-en-Y bypass8 Laparoscopic biliopancreatic diversion with duodenal switch as second stage for super super morbidly obese patients. Do all patients benefit?9 Sleeve gastrectomy in the super super morbidly obese (BMI > 60 kg/m2): a Canadian experience10 Laparoscopic gastric bypass for the treatment of refractory idiopathic gastroparesis: a report of 2 cases11 Duodeno-ileal switch as a primary bariatric and metabolic surgical option for the severely obese patient with comorbidities: review of a single-institution case series of duodeno-ileal intestinal bypass12 Management of large paraesophageal hernias in morbidly obese patients with laparoscopic sleeve gastrectomy: a case series13 Early results of the Ontario bariatric surgical program: using the bariatric registry14 Improving access to bariatric surgical care: Is universal health care the answer?15 Early and liberal postoperative exploration can reduce morbidity and mortality in patients undergoing bariatric surgery16 Withdrawn17 Identification and assessment of technical errors in laparoscopic Roux-en-Y gastric bypass18 A valid and reliable tool for assessment of surgical skill in laparoscopic Roux-en-Y gastric bypass19 Psychiatric predictors of presurgery drop-out following suitability assessment for bariatric surgery20 Predictors of outcomes following Roux-en-Y gastric bypass surgery at The Ottawa Hospital21 Prophylactic management of cholelithiasis in bariatric patients: Is routine cholecystectomy warranted?22 Early outcomes of Roux-en-Y gastric bypass in a publicly funded obesity program23 Similar incidence of gastrojejunal anastomotic stricture formation with hand-sewn and 21 mm circular stapler techniques during Roux-en-Y gastric bypass24 (CAGS Basic Science Award) Exogenous glucagon-like peptide-1 improves clinical, morphological and histological outcomes of intestinal adaptation in a distal-intestinal resection piglet model of short bowel syndrome25 (CAGS Clinical Research Award) Development and validation of a comprehensive curriculum to teach an advanced minimally invasive procedure: a randomized controlled trial26 Negative-pressure wound therapy (iVAC) on closed, high-risk incisions following abdominal wall reconstruction27 The impact of seed granting on research in the University of British Columbia Department of Surgery28 Quality of surgical care is inadequate for elderly patients29 Recurrence of inguinal hernia in general and hernia specialty hospitals in Ontario, Canada30 Oncostatin M receptor deficiency results in increased mortality in an intestinal ischemia reperfusion model in mice31 Laparoscopic repair of large paraesophageal hernias with anterior gastropexy: a multicentre trial32 Response to preoperative medical therapy predicts success of laparoscopic splenectomy for immune thrombocytopenic purpura33 Perioperative sepsis, but not hemorrhagic shock, promotes the development of cancer metastases in a murine model34 Measuring the impact of implementing an acute care surgery service on the management of acute biliary disease35 Patient flow and efficiency in an acute care surgery service36 The relationship between treatment factors and postoperative complications after radical surgery for rectal cancer37 Risk of ventral hernia after laparoscopic colon surgery38 Urinary metabolomics as a tool for early detection of Barrett’s and esophageal cancer39 Construct validity of individual and summary performance metrics associated with a computer-based laparo-scopic simulator40 Impact of a city-wide health system reorganization on emergency department visits in hospitals in surrounding communities41 Transcatheter aortic valve implantation for the nonoperative management of aortic stenosis: a cost-effectiveness analysis42 Breast cancer: racial differences in age of onset. A potential confounder in Canadian screening recommendations43 Risk taking in surgery: in and out of the comfort zone44 A tumour board in the office: Track those cancer patients!45 Increased patient BMI is not associated with advanced colon cancer stage or grade on presentation: a retrospective chart review46 Consensus statements regarding the multidisciplinary care of limb amputation patients in disasters or humanitarian emergencies. Report of the 2011 Humanitarian Action Summit Surgical Working Group on amputations following disasters or conflict47 Learning the CanMEDS role of professional: a pilot project of supervised discussion groups addressing the hidden curriculum48 Assessing the changing scope of training in Canadian general surgery programs: expected versus actual experience49 Predicting need for surgical management for massive gastrointestinal hemorrhage50 International health care experience: using CanMEDS to evaluate learning outcomes following a surgical mission in Mampong, Ghana51 The open abdomen: risk factors for mortality and rates of closure52 How surgeons think: an exploration of mental practice in surgical preparation53 The surgery wiki: a novel method for delivery of under-graduate surgical education54 Understanding surgical residents’ postoperative practices before implementing an enhanced recovery after surgery (ERAS) guideline at the University of Toronto55 From laparoscopic transabdominal to posterior retroperitoneal adrenalectomy: a paradigm shift in operative approach56 A retrospective audit of outcomes in patients over the age of 80 undergoing acute care abdominal surgery57 Canadian general surgery residents’ perspectives on work-hour regulations58 Timing of surgical intervention and its outcomes in acute appendicitis59 Preparing surgical trainees to deal with adverse events. An outline of learning issues60 Acute care surgical service: surgeon agreement at the time of handover61 Predicting discharge of elderly patients to prehospitalization residence following emergency general surgery62 Morbidity and mortality after emergency abdominal surgery in octo- and nonagenarians63 The impact of acute abdominal illness and urgent admission to hospital on the living situation of elderly patients64 A comparison of laparoscopic versus open subtotal gastrectomy for antral gastric adenocarcinoma: a North American perspective65 Minimally invasive excision of ectopic mediastinal parathyroid adenomas66 Perioperative outcomes of laparoscopic hernia repair in a tertiary care centre: a single institution’s experience67 Evaluation of a student-run, practical and didactic curriculum for preclerkship medical students68 Joseph Lister: Father of Modern Surgery69 Comparisons of melanoma sentinel lymph node biopsy prediction nomograms in a cohort of Canadian patients70 Local experience with myocutaneous flaps after extensive pelvic surgery71 The treatment of noncirrhotic splanchnic vein thrombosis: Is anticoagulation enough?72 Implementation of an acute care surgery service does not affect wait-times for elective cancer surgeries: an institutional experience73 Use of human collagen mesh for closure of a large abdominal wall defect, after colon cancer surgery, a case report74 The role of miR-200b in pulmonary hypoplasia associated with congenital diaphragmatic hernia75 Systematic review and meta-analysis of electrocautery versus scalpel for incising epidermis and dermis76 Accuracy of sentinel lymph node biopsy for early breast cancer in the community setting in St. John’s, New-foundland: results of a retrospective review77 Acute surgical outcomes in the 80 plus population78 The liberal use of platelets transfusions in the acute phase of trauma resuscitation: a systematic review79 Implementation of an acute care surgical on call program in a Canadian community hospital80 Short-term outcomes following paraesophageal hernia repair in the elderly patient81 First experience with single incision surgery: feasibility in the pediatric population and cost evaluation82 The impact of the establishment of an acute care surgery unit on the outcomes of appendectomies and cholecystectomies83 Description and preliminary evaluation of a low-cost simulator for training and evaluation of flexible endoscopic skills84 Tumour lysis syndrome in metastatic colon cancer: a case report85 Acute care surgery service model implementation study at a single institution86 Colonic disasters approached by emergent subtotal and total colectomy: lessons learned from 120 consecutive cases87 Acellular collagen matrix stent to protect bowel anastomoses88 Lessons we learned from preoperative MRI-guided wire localization of breast lesions: the University Health Network (UHN) experience89 Interim cost comparison for the use of platinum micro-coils in the operative localization of small peripheral lung nodules90 Routine barium esophagram has minimal impact on the postoperative management of patients undergoing esophagectomy for esophageal cancer91 Iron deficiency anemia is a common presenting issue with giant paraesophageal hernia and resolves following repair92 A randomized comparison of different ventilation strategies during thoracotomy and lung resection93 The Canadian Lung Volume Reduction Surgery study: an 8-year follow-up94 A comparison of minimally invasive versus open Ivor-Lewis esophagectomy95 A new paradigm in the follow-up after curative resection for lung cancer: minimal-dose CT scan allows for early detection of asymptomatic cancer activity96 Predictors of lymph node metastasis in early esophageal adenocarcinoma: Is endoscopic resection worth the risk?97 How well can thoracic surgery residents operate? Comparing resident and program director opinions98 The impact of extremes of age on short- and long-term outcomes following surgical resection of esophageal malignancy99 Epidermal growth factor receptor targeted gold nanoparticles for the enhanced radiation treatment of non–small cell lung cancer100 Laparoscopic Heller myotomy results in excellent outcomes in all subtypes of achalasia as defined by the Chicago classification101 Neoadjuvant chemoradiation versus surgery in managing esophageal cancer102 Quality of life postesophagectomy for cancer!103 The implementation, evolution and translocation of standardized clinical pathways can improve perioperative outcomes following surgical treatment of esophageal cancer104 A tissue-mimicking phantom for applications in thoracic surgical simulation105 Sublobar resection compared with lobectomy for early stage non–small cell lung cancer: a single institution study106 Not all reviews are equal: the quality of systematic reviews and meta-analyses in thoracic surgery107 Do postoperative complications affect health-related quality of life after video-assisted thoracoscopic lobectomy for patients with lung cancer? A cohort study108 Thoracoscopic plication for palliation of dyspnea secondary to unilateral diaphragmatic paralysis: A worthwhile venture?109 Thoracic surgery experience in Canadian general surgery residency programs110 Perioperative morbidity and pathologic response rates following neoadjuvant chemotherapy and chemoradiation for locally advanced esophageal carcinoma111 An enhanced recovery pathway reduces length of stay after esophagectomy112 Predictors of dysplastic and neoplastic progression of Barrett’s esophagus113 Recurrent esophageal cancer complicated by tracheoesophageal fistula: management by means of palliative airway stenting114 Pancreaticopleural fistula-induced empyema thoracis: principles and results of surgical management115 Prognostic factors of early postoperative mortality following right extended hepatectomy116 Optimizing steatotic livers for transplantation using a cell-penetrating peptide CPP-fused heme oxygenase117 Video outlining the technical steps for a robot-assisted laparoscopic pancreaticoduodenectomy118 Establishment of a collaborative group to conduct innovative clinical trials in Canada119 Hepatic resection for metastatic malignant melanoma: a systematic review and meta-analysis120 Acellular normothermic ex vivo liver perfusion for donor liver preservation121 Pancreatic cancer and predictors of survival: comparing the CA 19–9/bilirubin ratio with the McGill Brisbane Scoring System122 Staged liver resections for bilobar hepatic colorectal metastases: a single centre experience123 Economic model of observation versus immediate resection of hepatic adenomas124 Resection of colorectal liver metastasis in the elderly125 Acceptable long-term survival in patients undergoing liver resection for metastases from noncolorectal, non-neuroendocrine, nonsarcoma malignancies126 Patient and clinicopathological features and prognosis of CK19+ hepatocellular carcinomas: a case–control study127 The management of blunt hepatic trauma in the age of angioembolization: a single centre experience128 Liver resections for noncolorectal and non-neuroendocrine metastases: an evaluation of oncologic outcomes129 Developing an evidence-based clinical pathway for patients undergoing pancreaticoduodenectomy130 Hepatitis C infection and hepatocellular carcinoma in liver transplant: a 20 year experience131 The effect of medication on the risk of post-ERCP pancreatitis132 Temporal trends in the use of diagnostic imaging for patients with hepato-pancreato-biliary (HPB) conditions: How much ionizing radiation are we really using?196 A phase II study of aggressive metastasectomy for intra-and extrahepatic metastases from colorectal cancer133 Why do women choose mastectomy for breast cancer treatment? A conceptual framework for understanding surgical decision-making in early-stage breast cancer134 Synoptic operative reporting: documentation of quality of care data for rectal cancer surgery135 Learning curve analysis for cytoreductive surgery: a useful application of the cumulative sum (CUSUM) method136 Pancreatic cancer is strongly associated with a unique urinary metabolomic signature137 Concurrent neoadjuvant chemo/radiation in locally advanced breast cancer138 Impact of positron emission tomography on clinical staging of newly diagnosed rectal cancer: a specialized single centre retrospective study139 An evaluation of intraoperative Faxitron microradiography versus conventional specimen radiography for the excision of nonpalpable breast lesions140 Comparison of breast cancer treatment wait-times in the Southern Interior of British Columbia in 2006 and 2010141 Factors affecting lymph nodes harvest in colorectal carcinoma142 Laparoscopic adrenalectomy for metastases143 You have a message! Social networking as a motivator for fundamentals of laparoscopic surgery (FLS) training144 The evaluation and validation of a rapid diagnostic and support clinic for women assessment for breast cancer145 Oncoplastic breast surgery: oncologic benefits and limitations146 A qualitative study on rectal cancer patients’ preferences for location of surgical care147 The effect of surgery on local recurrence in young women with breast cancer148 Elevated IL-6 and IL-8 levels in tumour microenvironment is not associated with increased serum levels in humans with Pseudomyxoma peritonei and peritoneal mesothelioma149 Conversion from laparoscopic to open approach during gastrectomy: a population-based analysis150 A scoping review of surgical process improvement tools (SPITs) in cancer surgery151 Splenectomy during gastric cancer surgery: a population-based study152 Defining the polo-like kinase 4 (Plk4) interactome in cancer cell protrusions153 Neoadjuvant imatinib mesylate for locally advanced gastrointestinal stromal tumours154 Implementing results from ACOSOG Z0011: Practice-changing or practice-affirming?155 Should lymph node retrieval be a surgical quality indicator in colon cancer?156 Long-term outcomes following resection of retroperitoneal recurrence of colorectal cancer157 Clinical research in surgical oncology: an analysis of clinicaltrials.gov158 Radiation therapy after breast conserving surgery: When are we missing the mark?159 The accuracy of endorectal ultrasound in staging rectal lesions in patients undergoing transanal endoscopic microsurgery160 Quality improvement in gastrointestinal cancer surgery: expert panel recommendations for priority research areas161 Factors influencing the quality of local management of ductal carcinoma in situ: a cohort study162 Papillary thyroid microcarcinoma: Does size matter?163 Hyperthermic isolated limb perfusion for extremity soft tissue sarcomas: systematic review of clinical efficacy and quality assessment of reported trials164 Adherence to antiestrogen therapy in seniors with breast cancer: How well are we doing?165 Parathyroid carcinoma: Challenging the surgical dogma?166 A qualitative assessment of the journey to delayed breast reconstruction195 The role of yoga therapy in breast cancer patients167 Outcomes reported in comparative studies of surgical interventions168 Enhanced recovery pathways decrease length of stay following colorectal surgery, but how quickly do patients actually recover?169 The impact of complications on bed utilization after elective colorectal resection170 Impact of trimodal prehabilitation program on functional recovery after colorectal cancer surgery: a pilot study171 Complex fistula-in-ano: Should the plug be abandoned in favour of the LIFT or BioLIFT?172 Prognostic utility of cyclooxygenase-2 expression by colon and rectal cancer173 Laparoscopic right hemicolectomy with complete mesocolic excision provides acceptable perioperative outcomes but is complex and time-consuming: analysis of learning curves for a novice minimally invasive surgeon174 Intraoperative quality assessment following double stapled circular colorectal anastomosis175 Improving patient outcomes through quality assessment of rectal cancer care176 Are physicians willing to accept a decrease in treatment effectiveness for improved functional outcomes for low rectal cancer?177 Turnbull-Cutait delayed coloanal anastomosis for the treatment of distal rectal cancer: a prospective cohort study178 Preoperative high-dose rate brachytherapy in preparation for sphincter preservation surgery for patients with advanced cancer of the lower rectum179 Impact of an enhanced recovery program on short-term outcomes after scheduled laparoscopic colon resection180 The clinical results of the Turnbull-Cutait delayed coloanal anastomosis: a systematic review181 Is a vertical rectus abdominus flap (VRAM) necessary? An analysis of perineal wound complications182 Fistula plug versus endorectal anal advancement flap for the treatment of high transsphincteric cryptoglandular anal fistulas: a systematic review and meta-analysis183 Maternal and neonatal outcomes following colorectal cancer surgery184 Transanal drainage to treat anastomotic leaks after low anterior resection for rectal cancer: a valuable option185 Trends in colon cancer in Ontario: 2002–2009186 Validation of electronically derived short-term outcomes in colorectal surgery187 A population-based assessment of transanal and endoscopic resection for adenocarcinoma of the rectum188 Laparoscopic colorectal surgery in the emergency setting: trends in the province of Ontario from 2002 to 2009189 Prevention of perineal hernia after laparoscopic and robotic abdominoperineal resection: review with case series of internal hernia through pelvic mesh which was placed in attempt to prevent perineal hernia190 Effect of rectal cancer treatments on quality of life191 The use of antibacterial sutures as an adjunctive preventative strategy for surgical site infection in Canada: an economic analysis192 Impact of socioeconomic status on colorectal cancer screening and stage at presentation: preliminary results of a population-based study from an urban Canadian centre193 Initial perioperative results of the first transanal endoscopic microsurgery (TEM) program in the province of Quebec194 Use of negative pressure wound therapy decreases perineal wound infections following abdominal perineal resection." Canadian Journal of Surgery 55, no. 4 Suppl 1 (August 2012): S63—S135. http://dx.doi.org/10.1503/cjs.016712.

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Ulmer, C., L. Schaaf, W. Zopf, and W. Steurer. "In-vitro/ex-vivo HIPEC-Modelle zur Therapieeffizienzprüfung." Zeitschrift für Gastroenterologie 51, no. 08 (August 16, 2013). http://dx.doi.org/10.1055/s-0033-1353009.

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Clasen, S., D. Schmidt, A. Boss, D. Dietz, SM Kröber, C. Schraml, CD Claussen, and P. Pereira. "Mathematisches Modell der multipolaren Radiofrequenz-Ablation basierend auf experimentellen Ex-vivo-Untersuchungen." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 177, S 01 (April 20, 2005). http://dx.doi.org/10.1055/s-2005-868299.

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Hildebrand, P., M. Kleemann, L. Mirow, U. Roblick, C. Bürk, and H. Bruch. "Entwicklung eines perfundierten ex vivo Tomor-Mimic Modells zum Training der laparoskopischen Radiofrequenzablation." Ultraschall in der Medizin - European Journal of Ultrasound 27, S 1 (October 10, 2006). http://dx.doi.org/10.1055/s-2006-953842.

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Bergmann, H., D. Rogoll, W. Scheppach, R. Melcher, and E. Richling. "In vitro- und ex vivo-Modelle zum intestinalen Transport von Polyphenolen am Beispiel des Apfels (Malus domestica)." Zeitschrift für Gastroenterologie 48, no. 10 (September 28, 2010). http://dx.doi.org/10.1055/s-0030-1267715.

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Oberbeck, MB, M. Spoerl, A. Linder, K. Utpatel, M. Evert, N. Hosten, and C. Rosenberg. "Ex-vivo-Modell zur MRT-geführten Thermoablation in der perfundierten Niere - Modelletablierung und Effektivität der PRFS-Thermometrie." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 185, S 01 (April 26, 2013). http://dx.doi.org/10.1055/s-0033-1346237.

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Lang, D., D. Drömann, D. Branscheid, H. Schultz, P. Zabel, J. Gerdes, E. Vollmer, and T. Goldmann. "Ex vivo Kultur humaner Gewebe: Ein neuartiges Modell zur Untersuchung Chemotherapie-induzierter Effekte auf Proliferation und Apoptose bei NSCLC." Pneumologie 62, S 2 (April 7, 2008). http://dx.doi.org/10.1055/s-2008-1074246.

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Isfort, P., H. Witte, O. Slabu, T. Penzkofer, M. Baumann, P. Bruners, CK Kuhl, T. Schmitz-Rode, and AH Mahnken. "Effektivität von superparamegnetischen Eisenoxid-Nanopartikeln bei der Behandlung von Osteoidosteomen in einem ex-vivo Modell verglichen mit Radiofrequenzablation und Mikrowellenablation." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 184, no. 12 (November 30, 2012). http://dx.doi.org/10.1055/s-0032-1329770.

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Neumann, H., H. Diebel, M. Vieth, J. Siebler, and MF Neurath. "Vorstellung einer neuen Technik zur einfachen Entfernung des over-the-scope-clips (OTSC) – eine ex vivo Studie am EASIE Modell." Zeitschrift für Gastroenterologie 50, no. 09 (September 4, 2012). http://dx.doi.org/10.1055/s-0032-1322391.

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Begemann, GC, AH Mahnken, T. Ries, D. Briem, C. Nolte-Ernsting, G. Adam, and A. Koops. "16-Zeilen Spiral-CT des knöchernen Beckens nach Schraubenosteosynthese der iliosakralen Gelenke – Untersuchungen zur Dosisanpassung in einem ex-vivo Modell." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 179, S 1 (2007). http://dx.doi.org/10.1055/s-2007-976895.

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Ried, M., K. Bielenberg, R. Neu, Z. Sziklavari, T. Szöke, A. Liebold, HS Hofmann, and M. Hönicka. "Evaluierung der Kombination von Phosphodiesterase-Hemmung und Endothelinrezeptor-Antagonismus zur Behandlung der pulmonalen Hypertonie in einem humanen ex-vivo Modell." Pneumologie 67, S 01 (February 27, 2013). http://dx.doi.org/10.1055/s-0033-1334684.

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Koch, F., A. Vietze, C. Hoffmann, A. Linder, F. Dombrowski, and N. Hosten. "Das Isolierte Humane Lungenperfusionsmodell (IHLP): Ein ex-vivo-Modell zur Überprüfung der Wirksamkeit von interventionell-radiologischen Methoden beim Bronchialkarzinom am Beispiel der LITT." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 180, S 1 (2008). http://dx.doi.org/10.1055/s-2008-1073935.

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Bomati-Miguel, Oscar, Nuria Miguel-Sancho, Ibane Abasolo, Ana Paula Candiota, Alejandro G. Roca, Milena Acosta, Simó Schwartz, et al. "Ex vivo assessment of polyol coated-iron oxide nanoparticles for MRI diagnosis applications: toxicological and MRI contrast enhancement effects." Journal of Nanoparticle Research 16, no. 3 (February 2, 2014). http://dx.doi.org/10.1007/s11051-014-2292-7.

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Pybus, Hannah J., Amanda L. Tatler, Lowell T. Edgar, Reuben D. O’Dea, and Bindi S. Brook. "Reduced biomechanical models for precision-cut lung-slice stretching experiments." Journal of Mathematical Biology 82, no. 5 (March 15, 2021). http://dx.doi.org/10.1007/s00285-021-01578-2.

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AbstractPrecision-cut lung-slices (PCLS), in which viable airways embedded within lung parenchyma are stretched or induced to contract, are a widely used ex vivo assay to investigate bronchoconstriction and, more recently, mechanical activation of pro-remodelling cytokines in asthmatic airways. We develop a nonlinear fibre-reinforced biomechanical model accounting for smooth muscle contraction and extracellular matrix strain-stiffening. Through numerical simulation, we describe the stresses and contractile responses of an airway within a PCLS of finite thickness, exposing the importance of smooth muscle contraction on the local stress state within the airway. We then consider two simplifying limits of the model (a membrane representation and an asymptotic reduction in the thin-PCLS-limit), that permit analytical progress. Comparison against numerical solution of the full problem shows that the asymptotic reduction successfully captures the key elements of the full model behaviour. The more tractable reduced model that we develop is suitable to be employed in investigations to elucidate the time-dependent feedback mechanisms linking airway mechanics and cytokine activation in asthma.
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Hagenah, Jannis, Michael Scharfschwerdt, and Floris Ernst. "Aortic Valve Leaflet Shape Synthesis With Geometric Prior From Surrounding Tissue." Frontiers in Cardiovascular Medicine 9 (March 9, 2022). http://dx.doi.org/10.3389/fcvm.2022.772222.

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Even though the field of medical imaging advances, there are structures in the human body that are barely assessible with classical image acquisition modalities. One example are the three leaflets of the aortic valve due to their thin structure and high movement. However, with an increasing accuracy of biomechanical simulation, for example of the heart function, and extense computing capabilities available, concise knowledge of the individual morphology of these structures could have a high impact on personalized therapy and intervention planning as well as on clinical research. Thus, there is a high demand to estimate the individual shape of inassessible structures given only information on the geometry of the surrounding tissue. This leads to a domain adaptation problem, where the domain gap could be very large while typically only small datasets are available. Hence, classical approaches for domain adaptation are not capable of providing sufficient predictions. In this work, we present a new framework for bridging this domain gap in the scope of estimating anatomical shapes based on the surrounding tissue's morphology. Thus, we propose deep representation learning to not map from one image to another but to predict a latent shape representation. We formalize this framework and present two different approaches to solve the given problem. Furthermore, we perform a proof-of-concept study for estimating the individual shape of the aortic valve leaflets based on a volumetric ultrasound image of the aortic root. Therefore, we collect an ex-vivo porcine data set consisting of both, ultrasound volume images as well as high-resolution leaflet images, evaluate both approaches on it and perform an analysis of the model's hyperparameters. Our results show that using deep representation learning and domain mapping between the identified latent spaces, a robust prediction of the unknown leaflet shape only based on surrounding tissue information is possible, even in limited data scenarios. The concept can be applied to a wide range of modeling tasks, not only in the scope of heart modeling but also for all kinds of inassessible structures within the human body.
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Vignali, Emanuele, Emanuele Gasparotti, Katia Capellini, Benigno Marco Fanni, Luigi Landini, Vincenzo Positano, and Simona Celi. "Modeling biomechanical interaction between soft tissue and soft robotic instruments: importance of constitutive anisotropic hyperelastic formulations." International Journal of Robotics Research, July 14, 2020, 027836492092747. http://dx.doi.org/10.1177/0278364920927476.

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Cardiovascular diseases are the leading cause of death in the western countries. Robotic surgery recently emerged as a confirmed strategy in the cardiovascular field, especially thanks to the improvement of soft robotics. These techniques have demonstrated their potential in terms of speed of execution and precision. In this context, a deeper knowledge of the material properties of the blood vessels is required, especially for computational soft robotics applications. A constitutive model including the contribution of the collagen fibers families is needed to take hyperelasticity and anisotropy into account. For this purpose, four different models are presented: two fiber families with dispersion (2FFD), two fiber families without dispersion (2FF), four fiber families with dispersion (4FFD), and four fiber families without dispersion (4FF). A set of experimental biaxial data obtained from ex-vivo specimens was used to assess the model performances. Two fitting procedures were imposed: a procedure with no weighting of scores and a procedure with a weight set to enhance the model performances in the contact range. A finite element simulation of a contact procedure was developed to evaluate the effect on the contact pressures and forces according to the different model implementations. In particular, a minimally invasive aortic valve positioning process through a previously designed soft robot was simulated. The results confirmed the overall fitting procedure. The adoption of the weighting process for the fitting was successful, as it permitted an accurate prediction in the region of interest through models with less parameters.
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