Academic literature on the topic 'Modèle animal multifactoriel'
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Journal articles on the topic "Modèle animal multifactoriel":
FAVERDIN, P., D. M’HAMED, M. RICO-GÓMEZ, and R. VERITE. "La nutrition azotée influence l’ingestion chez la vache laitière." INRAE Productions Animales 16, no. 1 (February 9, 2003): 27–37. http://dx.doi.org/10.20870/productions-animales.2003.16.1.3642.
Dissertations / Theses on the topic "Modèle animal multifactoriel":
Lahogue, Caroline. "Stratégie de traitement visant les récepteurs 5-HT6 dans un modèle animal de schizophrénie innovant." Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMC433.
Schizophrenia (SCZ) is a multifactorial mental disease which has repercussions on patients' personal and professional lives. While at least 1/3 of patients with SCZ present a remission of symptoms, other patients display persistent or even an aggravation of symptoms over time. To improve current treatments by testing new therapeutic targets, animal models need to be improved to get closer to the etiology of SCZ. We have developed a new multifactorial model which combines in mouse a genetic factor (1st hit, deletion of the serine racemase gene) with an early environmental stress (2nd hit, maternal separation for 24h on postnatal day 9). Our behavioral study showed that the interaction between the two factors in 2-hit mice leads to productive-like symptoms and cognitive deficits, observed in SCZ. However, the ex-vivo electrophysiological study reveals no specific pathophysiology of the functional activity of the hippocampal CA1 field in this model. Then, we tested the efficacy of blockade of serotonin subtype 6 receptors (5-HT6R) with a selective antagonist, SB-271046. This blockade induces beneficial effects on cognitive deficits, particularly memory, by improving working memory and sociability deficits in 2-hit mice. Electrophysiological studies show that 5-HT6R antagonism facilitates glutamatergic neurotransmission by two distinct sex-dependent mechanisms: an indirect activation of pyramidal neurons in males via a blockade of GABAergic inhibition, and a direct activation of pyramidal neurons in females. In 2-hit mice, only the disinhibition mechanism of pyramidal neurons induced in males by 5-HT6R blockade is altered.This thesis shows the interest of developing multifactorial models to get closer to the complex etiology of SCZ. It also shows the potential of 5-HT6R to treat several SCZ-related deficits, which are currently untreated, and suggests that it could be a useful adjunct treatment to neuroleptics
Percelay, Solenn. "Validation d'un modèle murin de schizophrénie pour améliorer la recherche de nouveaux traitements : approche psychopharmacologique, en imagerie et en électrophysiologie A new 3-hit mouse model of schizophrenia built on genetic, early and late factors Functional dysregulations in CA1 hippocampal networks of a 3-hit mouse model of schizophrenia Olfactory laterality is valence-dependent in mice Assessing olfactory laterality in mice: new tool in preclinical psychiatric study Combination of MAP6 deficit, maternal separation and MK801 in female mice: a 3-hit animal model of neurodevelopmental disorder with cognitive deficits Antipsychotic lurasidone: Behavioural and pharmacokinetic data in C57BL/6 mice." Thesis, Normandie, 2021. http://www.theses.fr/2021NORMC403.
Affecting 1% of worldwide population, schizophrenia is a debilitating pathology. Whether the aetiology of schizophrenia remains unknown, its multifactorial aspect is conversely now well admitted, and certainly gathers genetic vulnerability and environmental factors. Actual treatments are still unmet, particularly for negative and cognitive symptoms. For a better translation from treatments design of schizophrenia to clinical efficiency, there is a crucial need to refine preclinical animal models that considers the multifactorial aspects of this disease.We developed a new murine multifactorial model of schizophrenia (3-hit), that possesses a strong construct validity. To this, we combined a genetic predisposition (1st hit: partial deletion of MAP-6) with an early postnatal stress (2nd hit: 24 h maternal separation at postnatal day 9), and a late cannabinoid exposure during adolescence (3rd hit: tetrahydrocannabinol THC from post-natal day 32 to 52; 8 mg/kg/day).First, we characterised a promising face validity through behavioural, imaging and electrophysiological studies. At behavioural level, we demonstrated that 3-hit mice displayed negative-like symptoms, cognitive deficits and altered olfactory laterality. Moreover, we showed a sensory motor gating deficit, that is a major translational clue for animal models of schizophrenia. Additionally, 3-hit mice displayed some characteristic morphological and functional impairments of the disease: reduced hippocampal volume, altered callosal fibres, glutamatergic and GABAergic neurotransmission dysfunctions. We moreover highlighted some sexual dimorphisms.Second, we compared deficits of 3-hit mice to those of others models of schizophrenia developed in our laboratory. Deficits induced by one factor, or combination of several factors, evidenced a synergistic effect, and not a simple addition between each of them.The 3-hit model therefore presents strong construct validity and promising face validity, encouraging to assess the pharmacological validity
Bourdenx, Mathieu. "Approche multifactorielle de la dégénérescence parkinsonienne." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0135/document.
The aim of this work was to focus on neurodegenerative mechanisms in the context of synucleinopathies, especially on Parkinson’s disease (PD). PD is characterized by the loss of dopaminergic neurons and the presence of intracytoplasmic proteinaceous inclusions named Lewy Bodies of which α-synuclein (α-syn) is the main protein component. To date, there are no curative treatments. Elucidating mechanisms underlying neurodegeneration in PD will allow the identification of new molecular targets for therapeutic intervention. My Ph.D. work intends multifactorial and translational approaches based on modelling, therapeutic intervention and mechanistic studies. We first focused on the development of new animal models of PD based on the use of viral vector-mediated overexpression of α-syn. This word allowed us to conclude on the absence of additive effect of ageing in α-syn-related toxicity, at least in the three investigated species. Then, we worked on two therapeutic strategies to overcome the lysosomal dysfunction occurring in PD. To do so, we first developed a biotechnological approach based on the use of acidic nanoparticles restoring acidic pH of sick lysosomes, and then we used a gene therapy approach based on the overexpression on a central modulator lysosomal biogenesis. We here demonstrated the interest of restoration of lysosomal physiology. Finally, we tested the “prion-like” hypothesis in a cohort of nonhuman primates and assessed the efficacy of a therapeutic approach using an oligomer modulator in mice. This work highlights the central role of α-syn in PD etiology and offers innovative strategies for both modelling and therapeutic intervention
Jiao, Hong. "Genetic dissection of multifactorial disease models in the rat /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-287-6.
Books on the topic "Modèle animal multifactoriel":
DRAGANI. Human Polygenic Diseases: Animal Models. Taylor & Francis, 1998.
Book chapters on the topic "Modèle animal multifactoriel":
Karalis, Katia P. "Multifactorial regulation of the corticotroph axis: animal models." In The Acth Axis: Pathogenesis, Diagnosis and Treatment, 47–64. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/978-1-4615-0501-3_3.
"The Biology of Cytokines: General Principles, Properties, and Lessons from Animal Models." In Cytokine Gene Polymorphisms in Multifactorial Conditions, 31–62. CRC Press, 2006. http://dx.doi.org/10.1201/9781420005325-9.
Alonazi, Fahad N., Yousef M. Hawsaw, Helal G. Alanazi, Adel M. Alqarni, Suad A. Alghamdi, and Rakan J. Alanazi. "Animal Models for Cancer." In Animal Models In Experimental Medicine, 1–19. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815196382124010004.
Macrì, Simone, Martina Proietti Onori, Veit Roessner, and Giovanni Laviola. "Animal Models Recapitulating the Multifactorial Origin of Tourette Syndrome." In International Review of Neurobiology, 211–37. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-411546-0.00008-1.
Rubattu, Speranza, Bruna Gigante, Rosita Stanzione, and Massimo Volpe. "Animal models of stroke: implications for genetic studies of human stroke." In Stroke Genetics, 115–26. Oxford University PressOxford, 2003. http://dx.doi.org/10.1093/oso/9780198515869.003.0005.
Bortolato, Marco, and Roberto Cadeddu. "Animal Models of Tic Disorders." In Tourette Syndrome, edited by Liana Fasching, Melanie Brady, and Flora M. Vaccarino, 277–98. 2nd ed. Oxford University Press, 2022. http://dx.doi.org/10.1093/med/9780197543214.003.0017.
Juriloff, Diana M. "Mapping Studies in Animal Models." In Cleft Lip And Palate, 265–82. Oxford University PressNew York, NY, 2002. http://dx.doi.org/10.1093/oso/9780195139068.003.0022.
Felice, Daniela, Anand Gururajan, Olivia F. O’Leary, and John F. Cryan. "Gene–environment interactions in animal models of depression and anxiety." In Genes, brain, and emotions, 63–76. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198793014.003.0006.
Pilkinton, Sophie, T. J. Hollingsworth, Brian Jerkins, and Monica M. Jablonski. "An Overview of Glaucoma: Bidirectional Translation between Humans and Pre-Clinical Animal Models." In Animal Models in Medicine and Biology [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97145.
Holmdahl, Rikard. "Experimental Models For RA." In Rheumatoid Arthritis, 41–52. Oxford University PressOxford, 2006. http://dx.doi.org/10.1093/oso/9780198566304.003.0004.
Conference papers on the topic "Modèle animal multifactoriel":
Miquel Bartual, Mijo. "Modificaciones del concepto de lo salvaje en el antropoceno." In III Congreso Internacional de Investigación en Artes Visuales :: ANIAV 2017 :: GLOCAL. Valencia: Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/aniav.2017.6345.