Academic literature on the topic 'Model mimicry'
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Journal articles on the topic "Model mimicry"
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Pimonov, V. I. "MIMICRY AND THEATRICALITY: A FORMAL MODEL." Izvestiya of the Samara Science Centre of the Russian Academy of Sciences. Social, Humanitarian, Medicobiological Sciences 24, no. 87 (2022): 83–90. http://dx.doi.org/10.37313/2413-9645-2022-24-87-83-90.
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Object of the article: mimicry and theatricality. Subject of the article: difference and similarity between mimicry and theatricality. Purpose of the research: creating the semiotic model of transformation of mimicry into theatricality. Results: in mimicry, three meta-roles are at play: the mimic, the dupe and the model. The mimic imitates signals, emitted by the model. The dupe, being an enemy of the mimic, is thus deceived by the mimic's signals. Mimicry can be expressed by the scheme: “A” acts in front of “B” in the role of “C”, where “A” is the mimic, “B” is the dupe - a victim of deception, “C” is the model. Mimicry formally resembles theatricality, where "A" is the character of the play (functionally corresponding to the mimic), "B" is the character-spectator, corresponding to the dupe (victim of deception), "C" is another character, functionally corresponding to the "model". Even so, the difference between signals in mimicry and signs in theater is crucial. Field of application: semiotics, literary studies. Conclusions: The mimicry-to-theatricality transformation requires a real or imaginary border between the space of everyday life and “marked” territory (museum, houseof-worship, stage) that serves as a stop-signal inhibiting (or preventing) automatic actions.
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Kikuchi, David W., and David W. Pfennig. "A Batesian mimic and its model share color production mechanisms." Current Zoology 58, no. 4 (August 1, 2012): 658–67. http://dx.doi.org/10.1093/czoolo/58.4.658.
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Abstract Batesian mimics are harmless prey species that resemble dangerous ones (models), and thus receive protection from predators. How such adaptive resemblances evolve is a classical problem in evolutionary biology. Mimicry is typically thought to be difficult to evolve, especially if the model and mimic produce the convergent phenotype through different proximate mechanisms. However, mimicry may evolve more readily if mimic and model share similar pathways for producing the convergent phenotype. In such cases, these pathways can be co-opted in ancestral mimic populations to produce high-fidelity mimicry without the need for major evolutionary innovations. Here, we show that a Batesian mimic, the scarlet kingsnake Lampropeltis elapsoides, produces its coloration using the same physiological mechanisms as does its model, the eastern coral snake Micrurus fulvius. Therefore, precise color mimicry may have been able to evolve easily in this system. Generally, we know relatively little about the proximate mechanisms underlying mimicry.
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Cheney, Karen L., and Isabelle M. Côté. "Aggressive mimics profit from a model–signal receiver mutualism." Proceedings of the Royal Society B: Biological Sciences 274, no. 1622 (June 25, 2007): 2087–91. http://dx.doi.org/10.1098/rspb.2007.0543.
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Mimetic species have evolved to resemble other species to avoid predation (protective mimicry) or gain access to food (aggressive mimicry). Mimicry systems are frequently tripartite interactions involving a mimic, model and ‘signal receiver’. Changes in the strength of the relationship between model and signal receiver, owing to shifting environmental conditions, for example, can affect the success of mimics in protective mimicry systems. Here, we show that an experimentally induced shift in the strength of the relationship between a model (bluestreak cleaner fish, Labroides dimidiatus ) and a signal receiver (staghorn damselfish, Amblyglyphidodon curacao ) resulted in increased foraging success for an aggressive mimic (bluestriped fangblenny, Plagiotremus rhinorhynchos ). When the parasite loads of staghorn damselfish clients were experimentally increased, the attack success of bluestriped fangblenny on damselfish also increased. Enhanced mimic success appeared to be due to relaxation of vigilance by parasitized clients, which sought cleaners more eagerly and had lower overall aggression levels. Signal receivers may therefore be more tolerant of and/or more vulnerable to attacks from aggressive mimics when the net benefit of interacting with their models is high. Changes in environmental conditions that cause shifts in the net benefits accrued by models and signal receivers may have important implications for the persistence of aggressive mimicry systems.
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Finkbeiner, Susan D., Patricio A. Salazar, Sofía Nogales, Cassidi E. Rush, Adriana D. Briscoe, Ryan I. Hill, Marcus R. Kronforst, Keith R. Willmott, and Sean P. Mullen. "Frequency dependence shapes the adaptive landscape of imperfect Batesian mimicry." Proceedings of the Royal Society B: Biological Sciences 285, no. 1876 (April 4, 2018): 20172786. http://dx.doi.org/10.1098/rspb.2017.2786.
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Despite more than a century of biological research on the evolution and maintenance of mimetic signals, the relative frequencies of models and mimics necessary to establish and maintain Batesian mimicry in natural populations remain understudied. Here we investigate the frequency-dependent dynamics of imperfect Batesian mimicry, using predation experiments involving artificial butterfly models. We use two geographically distinct populations of Adelpha butterflies that vary in their relative frequencies of a putatively defended model ( Adelpha iphiclus ) and Batesian mimic ( Adelpha serpa ). We found that in Costa Rica, where both species share similar abundances, Batesian mimicry breaks down, and predators more readily attack artificial butterfly models of the presumed mimic, A. serpa . By contrast, in Ecuador, where A. iphiclus (model) is significantly more abundant than A. serpa (mimic), both species are equally protected from predation. Our results provide compelling experimental evidence that imperfect Batesian mimicry is frequency-dependent on the relative abundance of models and mimics in natural populations, and contribute to the growing body of evidence that complex dynamics, such as seasonality or the availability of alternative prey, influence the evolution of mimetic traits.
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Jamie, Gabriel A. "Signals, cues and the nature of mimicry." Proceedings of the Royal Society B: Biological Sciences 284, no. 1849 (February 22, 2017): 20162080. http://dx.doi.org/10.1098/rspb.2016.2080.
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‘Mimicry’ is used in the evolutionary and ecological literature to describe diverse phenomena. Many are textbook examples of natural selection's power to produce stunning adaptations. However, there remains a lack of clarity over how mimetic resemblances are conceptually related to each other. The result is that categories denoting the traditional subdivisions of mimicry are applied inconsistently across studies, hindering attempts at conceptual unification. This review critically examines the logic by which mimicry can be conceptually organized and analysed. It highlights the following three evolutionarily relevant distinctions. (i) Are the model's traits being mimicked signals or cues? (ii) Does the mimic signal a fitness benefit or fitness cost in order to manipulate the receiver's behaviour? (iii) Is the mimic's signal deceptive? The first distinction divides mimicry into two broad categories: ‘signal mimicry’ and ‘cue mimicry’. ‘Signal mimicry’ occurs when mimic and model share the same receiver, and ‘cue mimicry’ when mimic and model have different receivers or when there is no receiver for the model's trait. ‘Masquerade’ fits conceptually within cue mimicry. The second and third distinctions divide both signal and cue mimicry into four types each. These are the three traditional mimicry categories (aggressive, Batesian and Müllerian) and a fourth, often overlooked category for which the term ‘rewarding mimicry’ is suggested. Rewarding mimicry occurs when the mimic's signal is non-deceptive (as in Müllerian mimicry) but where the mimic signals a fitness benefit to the receiver (as in aggressive mimicry). The existence of rewarding mimicry is a logical extension of the criteria used to differentiate the three well-recognized forms of mimicry. These four forms of mimicry are not discrete, immutable types, but rather help to define important axes along which mimicry can vary.
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Akcali, Christopher K., Hibraim Adán Pérez-Mendoza, David W. Kikuchi, and David W. Pfennig. "Multiple models generate a geographical mosaic of resemblance in a Batesian mimicry complex." Proceedings of the Royal Society B: Biological Sciences 286, no. 1911 (September 18, 2019): 20191519. http://dx.doi.org/10.1098/rspb.2019.1519.
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Batesian mimics—benign species that receive protection from predation by resembling a dangerous species—often occur with multiple model species. Here, we examine whether geographical variation in the number of local models generates geographical variation in mimic–model resemblance. In areas with multiple models, selection might be relaxed or even favour imprecise mimicry relative to areas with only one model. We test the prediction that model–mimic match should vary with the number of other model species in a broadly distributed snake mimicry complex where a mimic and a model co-occur both with and without other model species. We found that the mimic resembled its model more closely when they were exclusively sympatric than when they were sympatric with other model species. Moreover, in regions with multiple models, mimic–model resemblance was positively correlated with the resemblance between the model and other model species. However, contrary to predictions, free-ranging natural predators did not attack artificial replicas of imprecise mimics more often when only a single model was present. Taken together, our results suggest that multiple models might generate a geographical mosaic in the degree of phenotype matching between Batesian mimics and their models.
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Iserbyt, Arne, Jessica Bots, Stefan Van Dongen, Janice J. Ting, Hans Van Gossum, and Thomas N. Sherratt. "Frequency-dependent variation in mimetic fidelity in an intraspecific mimicry system." Proceedings of the Royal Society B: Biological Sciences 278, no. 1721 (March 2, 2011): 3116–22. http://dx.doi.org/10.1098/rspb.2011.0126.
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Contemporary theory predicts that the degree of mimetic similarity of mimics towards their model should increase as the mimic/model ratio increases. Thus, when the mimic/model ratio is high, then the mimic has to resemble the model very closely to still gain protection from the signal receiver. To date, empirical evidence of this effect is limited to a single example where mimicry occurs between species. Here, for the first time, we test whether mimetic fidelity varies with mimic/model ratios in an intraspecific mimicry system, in which signal receivers are the same species as the mimics and models. To this end, we studied a polymorphic damselfly with a single male phenotype and two female morphs, in which one morph resembles the male phenotype while the other does not. Phenotypic similarity of males to both female morphs was quantified using morphometric data for multiple populations with varying mimic/model ratios repeated over a 3 year period. Our results demonstrate that male-like females were overall closer in size to males than the other female morph. Furthermore, the extent of morphological similarity between male-like females and males, measured as Mahalanobis distances, was frequency-dependent in the direction predicted. Hence, this study provides direct quantitative support for the prediction that the mimetic similarity of mimics to their models increases as the mimic/model ratio increases. We suggest that the phenomenon may be widespread in a range of mimicry systems.
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Hlaváček, Antonín, Klára Daňková, Daniel Benda, Petr Bogusch, and Jiří Hadrava. "Batesian-Müllerian mimicry ring around the Oriental hornet (Vespa orientalis)." Journal of Hymenoptera Research 92 (August 31, 2022): 211–28. http://dx.doi.org/10.3897/jhr.92.81380.
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Mimicry is usually understood to be an adaptive resemblance between phylogenetically distant groups of species. In this study, we focus on Batesian and Müllerian mimicry, which are often viewed as a continuum rather than distinct phenomena, forming so-called Batesian-Müllerian mimicry rings. Despite potent defence and wide environmental niche of hornets, little attention has been paid to them as potential models in mimicry research. We propose a Batesian-Müllerian mimicry ring of the Oriental hornet (Vespa orientalis, Hymenoptera: Vespidae) consisting of eight species that coexist in the Mediterranean region. To reveal general ecological patterns, we reviewed their geographical distribution, phenology, and natural history. In accordance with the ‘model-first’ theory, Batesian mimics of this ring occurred later during a season than the Müllerian mimics. In the case of Batesian mimic Volucella zonaria (Diptera: Syrphidae), we presume that temperature-driven range expansion could lead to allopatry with its model, and, potentially, less accurate resemblance to an alternative model, the European hornet (Vespa crabro: Hymenoptera: Vespidae). Colour morphs of polymorphic species Cryptocheilus alternatus (Hymenoptera: Vespidae), Delta unguiculatum (Hymenoptera: Vespidae), Rhynchium oculatum (Hymenoptera: Vespidae), and Scolia erythrocephala (Hymenoptera: Scoliidae) appear to display distinct geographical distribution patterns, and this is possibly driven by sympatry with alternative models from the European hornet (Vespa crabro) complex. General coevolution patterns of models and mimics in heterogenous and temporally dynamic environments are discussed, based on observations of the proposed Oriental hornet mimicry ring.
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McLean, Donald James, and Marie E. Herberstein. "Mimicry in motion and morphology: do information limitation, trade-offs or compensation relax selection for mimetic accuracy?" Proceedings of the Royal Society B: Biological Sciences 288, no. 1952 (June 9, 2021): 20210815. http://dx.doi.org/10.1098/rspb.2021.0815.
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Many animals mimic dangerous or undesirable prey as a defence from predators. We would expect predators to reliably avoid animals that closely resemble dangerous prey, yet imperfect mimics are common across a wide taxonomic range. There have been many hypotheses suggested to explain imperfect mimicry, but comparative tests across multiple mimicry systems are needed to determine which are applicable, and which—if any—represent general principles governing imperfect mimicry. We tested four hypotheses on Australian ant mimics and found support for only one of them: the information limitation hypothesis. A predator with incomplete information will be unable to discriminate some poor mimics from their models. We further present a simple model to show that predators are likely to operate with incomplete information because they forage and make decisions while they are learning, so might never learn to properly discriminate poor mimics from their models. We found no evidence that one accurate mimetic trait can compensate for, or constrain, another, or that rapid movement reduces selection pressure for good mimicry. We argue that information limitation may be a general principle behind imperfect mimicry of complex traits, while interactions between components of mimicry are unlikely to provide a general explanation for imperfect mimicry.
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Holen, Øistein Haugsten, and Rufus A. Johnstone. "Reciprocal mimicry: kin selection can drive defended prey to resemble their Batesian mimics." Proceedings of the Royal Society B: Biological Sciences 285, no. 1890 (October 31, 2018): 20181149. http://dx.doi.org/10.1098/rspb.2018.1149.
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Established mimicry theory predicts that Batesian mimics are selected to resemble their defended models, while models are selected to become dissimilar from their mimics. However, this theory has mainly considered individual selection acting on solitary organisms such as adult butterflies. Although Batesian mimicry of social insects is common, the few existing applications of kin selection theory to mimicry have emphasized relatedness among mimics rather than among models. Here, we present a signal detection model of Batesian mimicry in which the population of defended model prey is kin structured. Our analysis shows for most of parameter space that increased average dissimilarity from mimics has a twofold group-level cost for the model prey: it attracts more predators and these adopt more aggressive attack strategies. When mimetic resemblance and local relatedness are sufficiently high, such costs acting in the local neighbourhood may outweigh the individual benefits of dissimilarity, causing kin selection to drive the models to resemble their mimics. This requires model prey to be more common than mimics and/or well-defended, the conditions under which Batesian mimicry is thought most successful. Local relatedness makes defended prey easier targets for Batesian mimicry and is likely to stabilize the mimetic relationship over time.
Dissertations / Theses on the topic "Model mimicry"
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Beatty, Keturi D. "Mediated chameleons: An integration of nonconscious behavioral mimicry and the parallel process model of nonverbal communication." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc9934/.
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This study explored the state of art education in Turkey as revealed by pre-service art education university instructors, and the potential of incorporating visual culture studies in pre-service art education in Turkey. The instructors' ideas about visual culture, and popular culture, the impact it might have, the content (objects), and the practices within the context of Turkey were examined. Visual culture was examined from an art education perspective that focuses on a pedagogical approach that emphasizes the perception and critique of popular culture and everyday cultural experiences, and the analysis of media including television programs, computer games, Internet sites, and advertisements. A phenomenological human science approach was employed in order to develop a description of the perception of visual culture in pre-service art education in Turkey as lived by the participants. In-person interviews were used to collect the data from a purposive sample of 8 faculty members who offered undergraduate and graduate art education pedagogy, art history, and studio courses within four-year public universities. This empirical approach sought to obtain comprehensive descriptions of an experience through semi-structural interviews. These interviews employed open-ended questions to gather information about the following: their educational and professional background; their definitions of art education and art teacher education and what it means for them to teach pre-service art education; critical reflections on the educational system of Turkey; perceptions of visual and popular culture; and finally individual approaches to teaching art education. This study was conducted for the purpose of benefiting pre-service art teacher education in general and specifically in Turkey. It provided the rationale, the nature, and pedagogy of visual culture as well as the why and how of visual culture art education in the context of Turkey. Furthermore, it provided insights into the potential contribution of the concept of visual culture to the understanding of art and improvement of art teacher training in the context of Turkey.
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Beatty, Keturi D. Anderson Karen Ann. "Mediated chameleons an integration of nonconscious behavioral mimicry and the parallel process model of nonverbal communication /." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/permalink/meta-dc-9934.
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Amela, Abellan Isaac. "Bioinformatics Approaches to Protein Interaction and Complexes: Application to Pathogen-Host Epitope Mimicry and to Fe-S Cluster Biogenesis Model." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/125908.
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Les interaccions antigen/anticòs són un dels tipus més interessants d’interaccions proteiques. La millor manera de prevenir les malalties causades per patògens és mitjançant l’ús de vacunes. L’aparició de la genòmica permet fer cerques a tot el genoma de nous candidats vacunals, tècnica anomenada vaccinologia inversa. L’estratègia més comuna on s’aplica la vaccinologia inversa és al disseny de vacunes de subunitats recombinants, que en general generen resposta immune humoral a causa de la presència d’epítops B en les proteïnes del patogen. Un problema important d’aquesta estratègia és la identificació de les proteïnes immunogèniques protectives del surfoma del patogen. El mimetisme epitòpic pot donar lloc a fenòmens autoimmunes relacionats amb diverses malalties humanes. El Capítol I d’aquesta tesi descriu una anàlisi computacional basat en la seqüència on, mitjançant l’aplicació de l’algorisme BLASTP, es van comparar bases de dades d’epítops B lineals coneguts i també de seqüències de proteïnes de superfície dels principals patògens bacterians respiratoris humans amb el proteoma humà. Es va trobar que cap dels 7353 epítops B lineals analitzats tenien regions d’identitat de seqüència amb proteïnes humanes capaces de generar anticossos i alhora que només l'1% de les 2175 proteïnes analitzades contenien alguna zona de seqüència compartida amb el proteoma humà. Aquestes troballes suggereixen l’existència d’un mecanisme per evitar l’autoimmunitat. També proposem una estratègia per corroborar o advertint sobre la viabilitat d’una proteïna que contingui un cert epítop B lineal de ser un bon candidat vacunal mitjançant estudis de vaccinologia inversa. En resum, els epítops sense cap tipus d’identitat de seqüència amb proteïnes humanes han de ser bons candidats vacunals, i al l’inrevés.
El docking proteic és un mètode computacional per predir la millor manera en què interactuen les proteïnes, però, és possible identificar quina és la millor solució d’un programa de docking? La resposta habitual a aquesta pregunta és la solució que tingui més alta puntuació als outputs dels programes de docking, però les interaccions entre proteïnes són processos dinàmics, i moltes vegades la regió d’interacció és prou àmplia com per permetre diferents orientacions i/o energies d'interacció entre elles. En alguns casos, com en un multímer, es poden donar diverses regions d’interacció entre els monòmers. Aquests processos dinàmics impliquen interaccions, amb desplaçaments de superfície entre proteïnes, que porten a assolir la configuració funcional del complex proteic. Així doncs, en molts casos no hi ha una solució estàtica i única per a la interacció entre proteïnes, sinó que es donen diverses configuracions que també haurien de ser analitzades perquè podrien ser importants. Per extreure el conjunt de solucions més representatives dels outputs dels programes de docking, al Capítol II d’aquesta tesi es detalla el desenvolupament d’una aplicació de clústering no supervisada i automàtica, anomenada DockAnalyse. Aquesta aplicació es basa en el mètode ja existent de clústering DBscan, mitjançant el qual es busquen continuïtats entre els clústers generats per la representació de les dades dels outputs de docking. El mètode de clústering DBSCAN és molt robust i resol alguns dels problemes d’inconsistència dels mètodes clàssics de clústering com el tractament dels valors atípics i la dependència alhora de definir prèviament el nombre de clústers. Mitjançant representacions gràfiques i molt visuals, DockAnalyse fa que la interpretació de les solucions de docking sigui més fàcil permetent-nos trobar les més representatives. S’ha utilitzat aquesta nova aplicació per analitzar diverses interaccions proteiques i així poder modelar el comportament dinàmic de la interacció entre les proteïnes d’un complex. DockAnalyse també pot fer-se servir per a descriure regions d’interacció entre proteïnes i, per tant, orientar en futurs assajos de docking flexibles. L’aplicació (feta amb el paquet R) és oberta i accessible.
La construcció dels Clústers Ferro-Sofre (ISC) en eucariotes implica interaccions entre diferents proteïnes, entre els quals es troba la proteïna Frataxina. Dèficits d'aquesta proteïna s'han associat amb excés de ferro dins del mitocondri i alteracions en la biogènesi dels ISC ja que es proposa que Frataxina actua com a donadora de ferro per a la construcció d'aquests ISC en aquest orgànul. Una reducció dràstica de Frataxina causa l'Atàxia de Friedreich, una malaltia neurodegenerativa hereditària humana que afecta principalment l'equilibri, la coordinació, els músculs i el cor. Aquest síndrome és l'atàxia autosòmica recessiva més comuna. Entre els mecanismes moleculars d' humans i de llevat que involucren Frataxina s'han trobat moltes similituds així que els llevats representen un bon model per a estudiar aquest procés. En llevat, el complex proteic que forma la plataforma central de muntatge dels passos inicials de la biogènesi dels ISC està composta per la Frataxina homòloga de llevat, el dímer Nfs1-Isd11 i la proteïna Isu. En general, està acceptat que la funció de les proteïnes implica interaccions amb altres proteïnes associades, però en aquest cas no se sap prou sobre l'estructura del complex de proteïnes i, per tant, com funciona exactament. En el Capítol III d'aquesta tesi es proposa un model del complex proteic necessari per a la biogènesi dels ISC amb el que es pretén aprofundir en detalls estructurals que expliquin la funció biològica. Per aconseguir aquest objectiu s'han utilitzat diverses eines de la bioinformàtiques, així com tècniques de modelització i programes de docking de proteïnes. Com a resultat, s'ha modelat l'estructura d'aquest complex proteic i també s'ha suggerit el comportament dinàmic dels seus components, juntament amb la dels àtoms de ferro i sofre necessaris per a la formació dels ISC. Aquestes hipòtesis podrien ajudar a comprendre millor la funció i les propietats moleculars de la proteïna Frataxina, així com els de les seves companyes presents al complex proteic.Antigen/antibody interactions are one of the most interesting kinds of protein interactions. The best way to prevent diseases caused by pathogens is by the use of vaccines. The advent of genomics enables genome-wide searches of new vaccine candidates, called reverse vaccinology. The most common strategy to apply reverse vaccinology is by designing subunit recombinant vaccines, which usually generate humoral immune response due to B-cell epitopes in proteins. A major problem for this strategy is the identification of protective immunogenic proteins from the surfome of the pathogen. Epitope mimicry may lead to auto-immune condition related to several human diseases. Chapter I of this thesis describes a sequence-based computational analysis that was carried out applying the BLASTP algorithm where databases containing the known linear B-cell epitopes and the surface-protein sequences of the main human respiratory bacterial pathogens were compared to the human proteome. We found that none of the 7353 linear B-cell epitopes analyzed share any sequence identity region with human proteins capable of generating antibodies, and that only 1% of the 2175 exposed proteins analyzed contain a stretch of shared sequence with the human proteome. These findings suggest the existence of a mechanism to avoid autoimmunity. We also propose a strategy for corroborating or warning about the viability of a protein linear B-cell epitope to be a putative vaccine candidate in reverse vaccinology studies. Therefore, epitopes without any sequence identity with human proteins should be good vaccine candidates, and the other way around. Protein docking is a computational method to predict the best way by which proteins interact, but, is it possible to identify what the best solution of a docking program is? The usual answer to this question is the highest score solution, but interactions between proteins are dynamic processes, and many times the interaction regions are wide enough to permit protein-protein interactions with different orientations and/or interaction energies. In some cases, as in a multimeric protein complex, several interaction regions are possible among the monomers. These dynamic processes involve interactions with surface displacements between the proteins to finally achieve the functional configuration of the protein complex. Consequently, there is not a static and single solution for the interaction between proteins, but there are several important configurations that also have to be analyzed. To extract those representative solutions from the docking output datafile, Chapter II of this thesis details the development of an unsupervised and automatic clustering application, named DockAnalyse. This application is based on the already existing DBscan clustering method, which searches for continuities among the clusters generated by the docking output data representation. The DBscan clustering method is very robust and, moreover, solves some of the inconsistency problems of the classical clustering methods like, for example, the treatment of outliers and the dependence of the previously defined number of clusters. DockAnalyse makes the interpretation of the docking solutions through graphical and visual representations easier by guiding the user to find the representative solutions. We have applied our new approach to analyze several protein interactions and model the dynamic protein interaction behavior of a protein complex. DockAnalyse might also be used to describe interaction regions between proteins and, therefore, guide future flexible dockings. The application (implemented in the R package) is accessible. The assembly of Iron-Sulfur Clusters (ISCs) in eukaryotes involves interactions between different proteins, among which is important the protein Frataxin. Deficits in this protein have been associated with iron inside the mitochondria and impaired ISC biogenesis as it is postulated to act as the iron donor for ISCs assembly in this organelle. A pronounced lack of Frataxin causes Friedreich's Ataxia, which is a human neurodegenerative and hereditary disease mainly affecting the equilibrium, coordination, muscles and heart. Moreover, it is the most common autosomal recessive ataxia. High similarities between the human and yeast molecular mechanisms that involve Frataxin have been suggested making yeast a good model to study that process. In yeast, the protein complex that forms the central assembly platform for the initial step of ISC biogenesis is composed by yeast Frataxin homolog, Nfs1-Isd11 and Isu. In general, it is commonly accepted that protein function involves interaction with other protein partners, but in this case not enough is known about the structure of the protein complex and, therefore, how it exactly functions. In Chapter III of this thesis a model of the ISC biogenesis protein complex was proposed in order to gain insight into structural details that could end up with its biological function. To achieve this goal several bioinformatics tools, modeling techniques and protein docking programs were used. As a result, the structure of the protein complex and the dynamic behavior of its components, along with that of the iron and sulfur atoms required for the ISC assembly, were modeled. This hypothesis might help to better understand the function and molecular properties of Frataxin as well as those of its ISC assembly protein partners.
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Li, Xiaoshuang. "Identification and Phenotypic Plasticity of Metastatic Cells in a Mouse Model of Melanoma." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3472.
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Melanoma is the deadliest form of skin cancer due to its high propensity to metastasize and resistance to current therapies. We have created a spontaneous mouse model of metastatic melanoma (Dct-Grm1/K5-Edn3) where metastasis to the lungs is 80% penetrant. The primary tumors of these mice present cellular heterogeneity with cells at varying levels of differentiation. The main goal of this study was to determine the metastatic potential of the primary tumor resident Tyrosinase positive cells and evaluate the dynamic phenotypic changes as those cells move from the primary tumors to the sites of metastasis. To accomplish this aim I crossed the Dct-Grm1/K5-Edn3 mice to CreERT2/mT/mG mice to indelibly label Tyrosinase cell populations within the primary tumor with Green Fluorescent Protein (GFP) by topical application of 4-hydroxytamoxifen (4HT) at the tumor site. In vivo lineage tracing and characterization of GFP+ cells were performed in the metastatic lesions.
In the 4HT treated Dct-Grm1/ K5-Edn3/Tyr-CreERT2/mT/mG mice, primary tumor derived Tyrosinase positive cells or their progeny (GFP+) established successful metastases in the distant organs indicating the tumorigenic capacity of the differentiated cell populations. Numerous metastatic melanoma cells were identified in the vasculature of the metastatic organs and established close association with the vascular endothelium. The intravascular cells lost pigmentation and did not express melanocytic markers; however, they mimicked endothelial cell properties and gained the expression of CD31 (also known as platelet endothelial cell adhesion molecule PECAM-1) and vascular endothelial (VE)-Cadherin. In the lung metastatic foci, GFP+ cells resumed pigmentation production and lost the expression of endothelial cell markers. Evidence from other metastatic organs in the mice further supported the phenotypic plasticity of metastatic melanoma cells.
The in vivo lineage tracing system established in the melanoma mouse model revealed tumor phenotypic plasticity and will be a powerful model to evaluate and help us understand the etiology and pathogenesis of melanoma metastasis. Further characterization of those more aggressive cells in melanoma will allow for the development of new prognostic tests and novel therapeutic strategies to eliminate metastasis.
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Lucca, Liliana. "Study of autoreative T cells exhibiting bi-specificity for a myelin and a neuronal antigen in a mouse model of multiple sclerosis." Toulouse 3, 2014. http://www.theses.fr/2014TOU30157.
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La sclérose en plaques (SEP) est une maladie neurologique causée par une inflammation du système nerveux central. Elle représente la cause non traumatique de handicap moteur chez les jeunes adultes et touche plus de 2. 5 millions de personnes dans le monde. Dans la SEP, le système immunitaire se trompe de cible et s'attaque à certains composants de la gaine qui isole les fibres nerveuses. Mon équipe d'accueil étudie les causes et conséquences de cette attaque mal dirigée. Spécifiquement, ils ont découvert que dans un modèle animal classique de SEP certaines cellules immunes reconnaissent simultanément deux composants de la fibre nerveuse en tant que cibles. Mon travail de recherche a consisté à caractériser ces cellules, leur origine, et à démontrer que cette double reconnaissance les rend plus pathogéniques. Mon travail sur ce nouveau mécanisme de l'auto-immunité va contribuer à clarifier la pathogenèse de la sclérose en plaquesMultiple sclerosis (MS) is a neurological disease caused by inflammation of the central nervous system. It represents the major non-traumatic cause of disability in young adults and affects 2. 5 million people worldwide. It is believed that in MS the immune system attacks molecular components of the myelin sheath that insulates nerve fibres. My host team research is dedicated to understanding the causes and consequences of this self-destructive behaviour of the immune system. In particular, they have discovered that in a classical animal model of MS certain immune cells recognize two molecular components of the neural fibre at the same time. My research work has consisted in characterizing these cells, understanding how they are generated and demonstrating that double-recognition enables them with a greater pathogenic potential. My work on this novel mechanism of autoimmunity contributes to shed light on the pathogenic processes underlying multiple sclerosis
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Schaefer, Martina Christina Marion. "The interaction between speech perception and speech production: implications for speakers with dysarthria." Thesis, University of Canterbury. Communication Disorders, 2013. http://hdl.handle.net/10092/8610.
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The purpose of the research presented here was to systematically investigate the role of speech perception on speech production in speakers of different ages and those with PD and hypokinetic dysarthria. For this, the experimental designs of auditory perturbation and mimicry were chosen. The initial research phase established that the magnitude of
compensation to auditory vowel perturbation was reduced in 54 speakers of New Zealand English (NZE) when compared to previous studies conducted with speakers of American (AE) and Canadian English (CE). A number of factors were studied to determine possible predictors of compensation and distinguish between potential changes associated with ageing.
However, no predictors of compensation were found for the overall group. Post-hoc analyses established an increased variability in response patterns in NZE when compared to previous studies of AE and CE. Subsequent follow-up analyses focused on the response-dependent categories of (1) big compensators, (2) compensators, (3) big followers, and (4) followers. Linear mixed-effect modelling revealed that in big compensators, the magnitude of compensation was greater in speakers who exhibited larger F1 baseline standard deviation
and greater F1 vowel distances of HEAD relative to HEED and HAD. F1 baseline standard deviation was found to have a similar predictive value for the group of compensators. No
predictors of compensation were found for the other two subgroups. Phase two was set up as a continuation of phase one and examined whether a subset of 16 speakers classified as big compensators adapted to auditory vowel perturbation. Linear mixed-effect modelling revealed that in the absence of auditory feedback alterations, big compensators maintained
their revised speech motor commands for a short period of time until a process of de-adaptation was initiated. No predictors of adaptation were found for the group. Due to the
unexpected results from the first two research phases indicating a dominant weighting of somatosensory feedback in NZE compared to auditory-perceptual influences, a different experimental paradigm was selected for phase three - mimicry. The purpose of this study was to determine whether eight speakers with PD and dysarthria and eight age-matched healthy controls (HC) are able to effectively integrate speech perception and speech production when attempting to match an acoustic target. Results revealed that all speakers were able to modify their speech production to approximate the model speaker but the acoustic dimensions of their speech did not move significantly closer to the target over the three mimicry attempts. Although speakers with moderate levels of dysarthria exhibited greater acoustic distances (except for the dimension of pitch variation), neither the perceptual nor the acoustic analyses found significant differences in mimicry behaviour across the two groups. Overall, these findings were considered preliminary evidence that speech perception and speech production can at least to some extent be effectively integrated to induce error-correction mechanisms and subsequent speech motor learning in these speakers with PD and dysarthria.
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Fung, Kwok Wing. "Models and mimics of Isopenicillin N Synthase." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335777.
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Cao, Chunhua. "Exploring the Test of Covariate Moderation Effect and the Impact of Model Misspecification in Multilevel MIMIC Models." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6688.
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In multilevel MIMIC models, covariates at the between level and at the within level can be modeled simultaneously. Covariates interaction effect occurs when the effect of one covariate on the latent factor varies depending on the level of the other covariate. The two covariates can be both at the between level, both at the within level, and one at the between level and the other one at the within level. And they can create between level covariates interaction, within level covariates interaction, and cross level covariates interaction. Study One purports to examine the performance of multilevel MIMIC models in estimating the covariates interaction described above. Type I error of falsely detecting covariates interaction when there is no covariates interaction effect in the population model, and the power of correctly detecting the covariates interaction effect, bias of the estimate of interaction effect, and RMSE are examined. The design factors include the location of the covariates interaction effect, cluster number, cluster size, intra-class correlation (ICC) level, and magnitude of the interaction effect. The results showed that ML MIMIC performed well in detecting the covariates interaction effect when the covariates interaction effect was at the within level or cross level. However, when the covariates interaction effect was at the between level, the performance of ML MIMIC depended on the magnitude of the interaction effect, ICC, and sample size, especially cluster size. In Study Two, the impact of omitting covariates interaction effect on the estimate of other parameters is investigated when the covariates interaction effect is present in the population model. Parameter estimates of factor loadings, intercepts, main effects of the covariates, and residual variances produced by the correct model in Study One are compared to those produced by the misspecified model to check the impact. Moreover, the sensitivity of fit indices, such as chi-square, CFI, RMSEA, SRMR-B (between), and SRM-W (within) are also examined. Results indicated that none of the fit indices was sensitive to the omission of the covariates interaction effect. The biased parameter estimates included the two covariates main effect and the between-level factor mean.
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Meunier, Hélène. "Etudes des mécanismes sous-jacents aux phénomènes collectifs chez un primate non humain, cebus capucinus: de l'expérimentation à la modélisation." Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210689.
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Ce doctorat trouve son origine dans la compréhension des prises de décision et des comportements collectifs des animaux. Comment ces derniers parviennent-ils à effectuer des choix collectivement ?Comment les membres d’un groupe procèdent-ils pour synchroniser leurs comportements spatialement et temporellement ?Mon principal objectif a été de dégager, lors des déplacements collectifs et du fur rubbing chez le capucin moine, les évènements décisionnels dépendants de processus anonymes de ceux dépendants de processus liés à l’identité des individus et à leur réseau de relations sociales au sein du groupe. Dans les prises de décision collective relatives aux déplacements, les membres du groupe sont influencés dans leurs choix par leur identité sociale mais aussi par des mécanismes anonymes, de type mimétique. Le fur rubbing est également un comportement collectif dont les mécanismes sous-jacents incluent une dépendance interindividuelle de type mimétique. Des mécanismes similaires mettant en jeu des interactions entre individus basées sur des règles comportementales simples se retrouvent dans chacun des phénomènes collectifs étudiés. Ces résultats sont les premiers à démontrer l’émergence de prises de décision collective à partir de telles interactions anonymes dans un groupe de primates non humains. Ils permettent de faire le lien entre choix individuels et comportement collectif et de mieux concevoir comment un groupe de primates peut se coordonner, maintenir sa cohésion spatiale et synchroniser ses activités./How do animals reach collective consensus? How do group members spatially and temporally synchronise their behaviour? My main purpose was to demonstrate the respective roles of anonymous processes (contagion, mimetism) and individual-dependent processes (hierarchical rank, age, sex, kin, social relationships) in collective decision-making. During decision-making relating to collective movements, group members’ decisions depend on their social identity (individual-dependent mechanism) as well as anonymous processes. Fur rubbing is also a collective behaviour involving interindividual dependence with mimetic underlying mechanisms. We found similar mechanisms, involving interindividual interactions according to simple behavioural rules, in both collective phenomenon studied. These results are the first to demonstrate the emergence of collective decision-making based on anonymous interactions in a group of non human primates. They help to understand the link between individual choices and collective behaviour and to appreciate how a social group of primates maintain its spatial cohesion and synchronize its activities.Doctorat en sciences, Spécialisation biologie animale
info:eu-repo/semantics/nonPublished
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Savle, Prashant S. "Thiazolium salts as thiamin models." Thesis, University of Cambridge, 1993. https://www.repository.cam.ac.uk/handle/1810/272636.
Full textBooks on the topic "Model mimicry"
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Fleming, Marnie Lynn. Jeannie Thib: Model/mimic. Oakville, Ont: Oakville Galleries, 1997.
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Rioux, Robert M. Model systems in catalysis: Single crystals to supported enzyme mimics. New York: Springer, 2010.
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Rioux, Robert M. Model systems in catalysis: Single crystals to supported enzyme mimics. New York: Springer, 2010.
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Bellers, Jürgen. Krimis, Kriminalität und politische Mimikri: Ein anthropologisches Modell von Medien und Politik. Siegen: Verlag Scyldamente, 2001.
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Ein MIMIC-Modell der subjektiven Rehabilitationsbedürftigkeit: Untersuchung zum Inanspruchnahmeverhalten hinsichtlich medizinischer Massnahmen zur Rehabilitation der Rentenversicherungsträger. Frankfurt am Main: P. Lang, 1993.
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Ruxton, Graeme D., William L. Allen, Thomas N. Sherratt, and Michael P. Speed. Batesian mimicry and masquerade. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199688678.003.0010.
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This chapter concerns Batesian mimicry, which is the resemblance of a palatable species to an unpalatable or otherwise unprofitable species. Often these unprofitable models have warning signals, which the mimic has evolved to copy. The chapter also considers another well-known form of deception, namely masquerade, which is the resemblance of a palatable species to the cues of an object of no inherent interest to a potential predator such as leaves, thorns, sticks, stones, or bird droppings. Batesian mimicry and masquerade share many properties, and both can be considered examples of ‘protective deceptive mimicry’. We begin by briefly reviewing some well-known examples of protective deceptive mimicry. We then compare and contrast the various theories that have been proposed to understand them. Next, we examine the evidence for the phenomenon and its predicted properties, and finally we address several important questions and controversies, many of which remain only partly resolved.
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Ferrari, G. R. F. Storytelling as Intimation. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198798422.003.0004.
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The chapter argues against a ‘conversational’ model of the relation between storyteller and audience, on the grounds that it puts the storyteller at too little distance from the audience. Although more overt than intimation at the half-on position (since the transmission is required to come across by recognition of the intention of the transmitting party), the storyteller’s intimation still lacks the complete overtness of full-on communication (since that recognition is only partial); hence its ‘three-quarters-on’ position. Contrast the full covertness of the quarter-on position, whose underlying form is: I want you to know (something), but I also want you not to know that I want you to know (that thing). Lyric poetry, which comes alive for us by masking its own artificiality, belongs here. A derivation is then proposed that makes mimicry fundamental to storytelling’s manner of intimation, rendering theoretical appeal to make-believe, imagination, or the authorial ‘persona’ unnecessary.
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Rioux, Robert. Model Systems in Catalysis: Single Crystals to Supported Enzyme Mimics. Springer, 2010.
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Rioux, Robert. Model Systems in Catalysis: Single Crystals to Supported Enzyme Mimics. Springer, 2014.
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Algom, Daniel, Ami Eidels, Robert X. D. Hawkins, Brett Jefferson, and James T. Townsend. Features of Response Times. Edited by Jerome R. Busemeyer, Zheng Wang, James T. Townsend, and Ami Eidels. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199957996.013.4.
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Psychology is one of the most recent sciences to issue from the mother-tree of philosophy. One of the greatest challenges is that of formulating theories and methodologies that move the field toward theoretical structures that are not only sufficient to explain and predict phenomena but, in some vital sense, necessary for those purposes. Mathematical modeling is perhaps the most promising general strategy, but even under that aegis, the physical sciences have labored toward that end. The present chapter begins by outlining the roots of our approach in 19th century physics, physiology, and psychology. Then, we witness the renaissance of goals in the 1960s, which were envisioned but not usually realizable in 19th century science and methodology. It could be contended that it is impossible to know the full story of what can be learned through scientific method in the absence of what cannot be known. This precept brings us into the slough of model mimicry, wherein even diametrically opposed physical or psychological concepts can be mathematically equivalent within specified observational theatres! Discussion of examples from close to half a century of research illustrate what we conceive of as unfortunate missteps from the psychological literature as well as what has been learned through careful application of the attendant principles. We conclude with a statement concerning ongoing expansion of our body of approaches and what we might expect in the future.
Book chapters on the topic "Model mimicry"
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Osheroff, Phyllis L. "Anti-Idiotypes and Lymphokine Receptors: Interferon as a Model." In Anti-Idiotypes, Receptors, and Molecular Mimicry, 255–66. New York, NY: Springer New York, 1988. http://dx.doi.org/10.1007/978-1-4612-3734-1_16.
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Ardman, Blair, and Susan Burdette. "Anti-Idiotypes, Retrovirus Receptors, and an Idiotypic Network in a Model of Retrovirus-Induced Thymic Leukemia." In Anti-Idiotypes, Receptors, and Molecular Mimicry, 267–83. New York, NY: Springer New York, 1988. http://dx.doi.org/10.1007/978-1-4612-3734-1_17.
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Liu, Wei, Yufei Peng, Zhao Tian, Yang Li, and Wei She. "A Medical Blockchain Privacy Protection Model Based on Mimicry Defense." In Lecture Notes in Computer Science, 581–92. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-57881-7_51.
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Nishida, Ritsuo. "Chemical Ecology of Poisonous Butterflies: Model or Mimic? A Paradox of Sexual Dimorphisms in Müllerian Mimicry." In Diversity and Evolution of Butterfly Wing Patterns, 205–20. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4956-9_11.
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Froude, J., A. Gibofsky, D. R. Buskirk, A. Khanna, and J. B. Zabriskie. "Cross-Reactivity Between Streptococcus and Human Tissue: A Model of Molecular Mimicry and Autoimmunity." In Current Topics in Microbiology and Immunology, 5–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74594-2_2.
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de Andrade Peixoto, Maíra, Emily Marques dos Reis, and Luismar Marques Porto. "Cancer Cell Spheroids as a 3D Model for Exploring the Pathobiology of Vasculogenic Mimicry." In Methods in Molecular Biology, 45–51. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2403-6_5.
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Blank, Miri, Ilan Krause, and Yehuda Shoenfeld. "Molecular Mimicry: Lessons from Experimental Models of Systemic Lupus Erythematosus and Antiphospholipid Syndrome." In Molecular Mimicry, Microbes, and Autoimmunity, 223–33. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555818074.ch16.
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Butler, Alison, and Anne H. Baldwin. "Vanadium bromoperoxidase and functional mimics." In Metal Sites in Proteins and Models, 109–32. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-62874-6_10.
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Bragdon, Joseph H. "What we can learn from the Nordic Model." In Economies That Mimic Life, 136–49. Abingdon, Oxon; New York, NY: Routledge, 2021.: Routledge, 2021. http://dx.doi.org/10.4324/9781003109877-10.
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Tsunoda, Ikuo, and Robert S. Fujinami. "TMEV and Neuroantigens: Myelin Genes and Proteins, Molecular Mimicry, Epitope Spreading, and Autoantibody-Mediated Remyelination." In Experimental Models of Multiple Sclerosis, 593–616. Boston, MA: Springer US, 2005. http://dx.doi.org/10.1007/0-387-25518-4_29.
Full textConference papers on the topic "Model mimicry"
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Premaratne, Upeka, Areski Nait-Abdallah, Jagath Samarabandu, and Tarlochan Sidhu. "A formal model for masquerade detection software based upon natural mimicry." In 2010 5th International Conference on Information and Automation for Sustainability (ICIAfS). IEEE, 2010. http://dx.doi.org/10.1109/iciafs.2010.5715627.
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Nagel, Jacquelyn K. S., Robert B. Stone, and Daniel A. McAdams. "Exploring the Use of Category and Scale to Scope a Biological Functional Model." In ASME 2010 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/detc2010-28873.
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The natural world provides numerous cases for analogy and inspiration in engineering design. Biological organisms, phenomena and strategies, herein referred to as biological systems, are, in essence, living engineered systems. These living systems provide insight into sustainable and adaptable design and offer engineers billions of years of valuable experience, which can be used to inspire engineering innovation. This research presents a general method for functionally representing biological systems through systematic design techniques, affording conceptualization of biologically-inspired, engineering designs. Functional representation and abstraction techniques are utilized to translate biological systems into an engineering context. Thus, the biological system information is accessible to engineering designers with varying biological knowledge, but a common understanding of engineering design methods. Functional modeling is typically driven by customer needs or product re-designs; however, these cannot be applied to biological systems. Thus, we propose the use of biological category and scale to guide the design process. Mimicry categories and scales, in addition to answering a design question, aid the designer with defining boundaries or scope when developing a biological functional model. Biological category assists with framing the information in the right perspective, where as, biological scale deals with how much detail is required for an adequate representation of the biological system to utilize the information with a chosen engineering design method. In our case, the engineering design method is function-based design. Choosing a category serves to refine the boundary, but, like scale, its consideration might prompt the designer to consider the same biological system in a new and unique way leading to new ideas. General guidelines for modeling biological systems at varying scales and categories are given, along with two modeling examples.
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Bhasin, Devesh, and Daniel A. McAdams. "Fostering Function-Sharing Using Bioinspired Product Architecture." In ASME 2020 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/detc2020-22580.
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Abstract In this work, we deduce principles of bioinspired product architectures to leverage biological function-sharing in engineering design. Function-sharing allows multiple functions to be performed by a single structure and can lead to improvements in cost, weight and other performance characteristics. Billions of years of evolution has led to the emergence of function-sharing adaptations in biological systems. However, the current practice of bioinspired function-sharing is largely limited to the solution-driven mimicry of biological structures. In order to effectively leverage biological function-sharing in engineering design, we model and analyze the product architectures of five generalized case studies from the animal kingdom. Further, we create a categorization framework to explore patterns in the function-sharing scenarios associated with biological product architectures. Our results indicate the existence of four types of modules in the biological systems from the animal kingdom. We use the classification framework to deduce four guidelines for the bioinspiration of product architectures. The deduced guidelines can allow engineers to identify and implement novel function-sharing scenarios in early stages of product design. The application of the guidelines has been demonstrated by using a case study.
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Khoda, A. K. M. B., and Bahattin Koc. "Functionally Heterogeneous Porous Scaffold Design for Tissue Engineering." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-86927.
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Most of the current tissue scaffolds are mainly designed with homogeneous porosity which does not represent the spatial heterogeneity found in actual tissues. Therefore engineering a realistic tissue scaffolds with properly graded properties to facilitate the mimicry of the complex elegance of native tissues are critical for the successful tissue regeneration. In this work, novel bio-mimetic heterogeneous porous scaffolds have been modeled. First, the geometry of the scaffold is extracted along with its internal regional heterogeneity. Then the model has been discretized with planner slices suitable for layer based fabrication. An optimum filament deposition angle has been determined for each slice based on the contour geometry and the internal heterogeneity. The internal region has been discritized considering the homogeneity factor along the deposition direction. Finally, an area weight based approach has been used to generate the spatial porosity function that determines the filament deposition location for desired bio-mimetic porosity. The proposed methodology has been implemented and illustrative examples are provided. The effective porosity has been compared between the proposed design and the conventional homogeneous scaffolds. The result shows a significant error reduction towards achieving the bio-mimetic porosity in the scaffold design and provides better control over the desired porosity level. Moreover, sample designed structures have also been fabricated with a NC motion controlled micro-nozzle biomaterial deposition system.
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Tsoularis, A., Tuan D. Pham, and Xiaobo Zhou. "A Stochastic Optimal Control Problem For Predation of Models And Mimics." In COMPUTATIONAL MODELS FOR LIFE SCIENCES/CMLS '07. AIP, 2007. http://dx.doi.org/10.1063/1.2816634.
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Collares, Tiago, Fabiana K. Seixas, Laurie A. Rund, Wenping Hu, Fernanda M. Rodrigues, Ying Liang, Kuldeep Singh, Cristopher M. Counter, and Lawrence B. Schook. "Abstract A21: Transgenic Onco-Pig cells mimic human cancer." In Abstracts: AACR Special Conference: The Translational Impact of Model Organisms in Cancer; November 5-8, 2013; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1557-3125.modorg-a21.
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Heule, Stefan, Manu Sridharan, and Satish Chandra. "Mimic: computing models for opaque code." In ESEC/FSE'15: Joint Meeting of the European Software Engineering Conference and the ACM SIGSOFT Symposium on the Foundations of Software Engineering. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2786805.2786875.
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Tsoularis, A., Theodore E. Simos, George Psihoyios, and Ch Tsitouras. "Optimal Control In Predation Of Models And Mimics." In Numerical Analysis and Applied Mathematics. AIP, 2007. http://dx.doi.org/10.1063/1.2790206.
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Lin, Stephanie, Jacob Hilton, and Owain Evans. "TruthfulQA: Measuring How Models Mimic Human Falsehoods." In Proceedings of the 60th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). Stroudsburg, PA, USA: Association for Computational Linguistics, 2022. http://dx.doi.org/10.18653/v1/2022.acl-long.229.
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Suzuki, Shura, Akira Fukuhara, Dai Owaki, Takeshi Kano, Auke J. Ijspeert, and Akio Ishiguro. "A simple body-limb coordination model that mimics primitive tetrapod walking." In 2017 56th Annual Conference of the Society of Instrument and Control Engineers of Japan (SICE). IEEE, 2017. http://dx.doi.org/10.23919/sice.2017.8105624.
Full textReports on the topic "Model mimicry"
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Bano, Masooda. International Push for SBMCs and the Problem of Isomorphic Mimicry: Evidence from Nigeria. Research on Improving Systems of Education (RISE), July 2022. http://dx.doi.org/10.35489/bsg-rise-wp_2022/102.
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Establishing School-Based Management Committees (SBMCs) is one of the most widely adopted and widely studied interventions aimed at addressing the learning crisis faced in many developing countries: giving parents and communities a certain degree of control over aspects of school management is assumed to increase school accountability and contribute to improvements in learning. Examining the case of Nigeria, which in 2005 adopted a national policy to establish SBMCs in state schools, this paper reviews the evidence available on SBMCs’ ability to mobilise communities, and the potential for this increased community participation to translate into improved learning. The paper shows that while local community participation can help improve school performance, the donor and state supported SBMCs struggle to stay active and have positive impact on school performance. Yet for ministries of education in many developing countries establishing SBMCs remains a priority intervention among the many initiatives aimed at improving education quality. The paper thus asks what makes the establishment of SBMCs a priority intervention for the Nigerian government. By presenting an analysis of the SBMC-related policy documents in Nigeria, the paper demonstrates that an intervention aimed at involving local communities and developing bottom-up approaches to identifying and designing education policies is itself entirely a product of top-down policy making, envisioned, developed, and funded almost entirely by the international development community. The entire process is reflective of isomorphic mimicry—a process whereby organisations attempt to mimic good behaviour to gain legitimacy, instead of fixing real challenges. Adopting the policy to establish SBMCs, which is heavily promoted by the international development community and does not require actual reform of the underlying political-economy challenges hindering investment in education, enables education ministries to mimic commitment to education reforms and attain the endorsement of the international community without addressing the real challenges. Like all cases of isomorphic mimicry, such policy adoption and implementation has costs: national ministries, as well as state- and district-level education authorities, end up devoting time, resources, and energy to planning, designing, and implementing an intervention for which neither the need nor the evidence of success is established. Additionally, such top-down measures prevent state agencies from identifying local opportunities for delivering the same goals more effectively and perhaps at a lower cost. The paper illustrates this with the case of the state of Kano: there is a rich indigenous culture of supporting community schools, yet, rather than learning why local communities support certain kinds of school but not state schools, and trying to replicate the lessons in state schools, the SBMC model introduced is designed by development agencies at the national level and is administratively complicated and resource-intensive. The opportunity for local learning has not been realised; instead, both the agenda and the implementation framework have been entirely shaped by international aid agencies. The paper thus demonstrates how apparently positive policy interventions resulting from pressure exerted by the international community could be having unintended consequences, given the national-level political-economy dynamics.
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Pailino, Lia, Lihua Lou, Alberto Sesena Rubfiaro, Jin He, and Arvind Agarwal. Nanomechanical Properties of Engineered Cardiomyocytes Under Electrical Stimulation. Florida International University, October 2021. http://dx.doi.org/10.25148/mmeurs.009775.
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Engineered cardiomyocytes made of human-induced pluripotent stem cells (iPSC) present phenotypical characteristics similar to human fetal cardiomyocytes. There are different factors that are essential for engineered cardiomyocytes to be functional, one of them being that their mechanical properties must mimic those of adult cardiomyocytes. Techniques, such as electrical stimulation, have been used to improve the extracellular matrix's alignment and organization and improve the intracellular environment. Therefore, electrical stimulation could potentially be used to enhance the mechanical properties of engineered cardiac tissue. The goal of this study is to establish the effects of electrical stimulation on the elastic modulus of engineered cardiac tissue. Nanoindentation tests were performed on engineered cardiomyocyte constructs under seven days of electrical stimulation and engineered cardiomyocyte constructs without electrical stimulation. The tests were conducted using BioSoft™ In-Situ Indenter through displacement control mode with a 50 µm conospherical diamond fluid cell probe. The Hertzian fit model was used to analyze the data and obtain the elastic modulus for each construct. This study demonstrated that electrically stimulated cardiomyocytes (6.98 ± 0.04 kPa) present higher elastic modulus than cardiomyocytes without electrical stimulation (4.96 ± 0.29 kPa) at day 7 of maturation. These results confirm that electrical stimulation improves the maturation of cardiomyocytes. Through this study, an efficient nanoindentation method is demonstrated for engineered cardiomyocyte tissues, capable of capturing the nanomechanical differences between electrically stimulated and non-electrically stimulated cardiomyocytes.
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Gordon, Dalia, Ke Dong, and Michael Gurevitz. Unexpected Specificity of a Sea Anemone Small Toxin for Insect Na-channels and its Synergic Effects with Various Insecticidal Ligands: A New Model to Mimic. United States Department of Agriculture, November 2010. http://dx.doi.org/10.32747/2010.7697114.bard.
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Motivated by the high risks to the environment and human health imposed by the current overuse of chemical insecticides we offer an alternative approach for the design of highly active insect-selective compounds that will be based on the ability of natural toxins to differentiate between insect and mammalian targets. We wish to unravel the interacting surfaces of insect selective toxins with their receptor sites on voltage-gated sodium channels. In this proposal we put forward two recent observations that may expedite the development of a new generation of insect killers that mimic the highly selective insecticidal toxins: (i) A small (27aa) highly insecticidal sea anemone toxin, Av3, whose toxicity to mammals is negligible; (ii) The prominent positive cooperativity between distinct channel ligands, such as the strong enhancement of pyrethroids effects by anti-insect selective scorpion depressant toxins. We possess a repertoire of insecticidal toxins and sodium channel subtypes all available in recombinant form for mutagenesis followed by analysis of various pharmacological, electrophysiological, and structural methods. Our recent success to express Av3 provides for the first time a selective toxin for receptor site-3 on insect sodium channels. In parallel, our recent success to determine the structures and bioactive surfaces of insecticidal site-3 and site-4 toxins establishes a suitable system for elucidation of toxin-receptor interacting faces. This is corroborated by our recent identification of channel residues involved with these two receptor sites. Our specific aims in this proposal are to (i) Determine the bioactive surface of Av3 toward insect Na-channels; (ii) Identify channel residues involved in binding or activity of the insecticidal toxins Av3 and LqhaIT, which differ substantially in their potency on mammals; (iii) Illuminate channel residues involved in recognition by the anti-insect depressant toxins; (iv) Determine the face of interaction of both site-3 (Av3) and site-4 (LqhIT2) toxins with insect sodium channels using thermodynamic mutant cycle analysis; and, (v) Examine whether Av3, LqhIT2, pyrethroids, and indoxacarb (belongs to a new generation of insecticides), enhance allosterically the action of one another on the fruit fly and cockroach paraNa-channels and on their kdr and super-kdr mutants. This research establishes the grounds for rational design of novel anti-insect peptidomimetics with minimal impact on human health, and offers a new approach in insect pest control, whereby a combination of allosterically interacting compounds increases insecticidal action and reduces risks of resistance buildup.
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Heitman, Joseph. Novel Gbeta Mimic Kelch Proteins (Gpb1 and Gpb2 Connect G-Protein Signaling to Ras via Yeast Neurofibromin Homologs Ira1 and Ira2: A Model for Human NF1. Fort Belvoir, VA: Defense Technical Information Center, March 2008. http://dx.doi.org/10.21236/ada483900.
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Heitman, Joseph, and Toshiaki Harashima. Novel Gbeta Mimic Kelch Proteins (Gpb1 and Gpb2 Connect G-Protein Signaling to Ras via Yeast Neurofibromin Homologs Ira1 and Ira2. A Model for Human NF1. Fort Belvoir, VA: Defense Technical Information Center, March 2007. http://dx.doi.org/10.21236/ada479028.
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Heitman, Joseph, and Toshiaki Harashima. Novel Gbeta Mimic Kelch Proteins Gpb1 and Gpb2 Connect G-Protein Signaling to Ras Via Yeast Neurofibromin Homologs Ira 1 and Ira 2: A Model for Human NF1. Fort Belvoir, VA: Defense Technical Information Center, March 2005. http://dx.doi.org/10.21236/ada446943.
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Heitman, Joseph. Novel Gbeta Mimic Kelch Proteins Gpb1 and Gpb2 Connect G-Protein Signaling to Ras via Yeast Neurofibromin Homologs Ira 1 and Ira 2: A Model for Human NF1. Fort Belvoir, VA: Defense Technical Information Center, March 2006. http://dx.doi.org/10.21236/ada469875.
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Kamai, Tamir, Gerard Kluitenberg, and Alon Ben-Gal. Development of heat-pulse sensors for measuring fluxes of water and solutes under the root zone. United States Department of Agriculture, January 2016. http://dx.doi.org/10.32747/2016.7604288.bard.
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The objectives defined for this study were to: (1) develop a heat-pulse sensor and a heat-transfer model for leaching measurement, and (2) conduct laboratory study of the sensor and the methodology to estimate leaching flux. In this study we investigated the feasibility for estimating leachate fluxes with a newly designed heat-pulse (HP) sensor, combining water flux density (WFD) with electrical conductivity (EC) measurements in the same sensor. Whereas previous studies used the conventional heat pulse sensor for these measurements, the focus here was to estimate WFD with a robust sensor, appropriate for field settings, having thick-walled large-diameter probes that would minimize their flexing during and after installation and reduce associated errors. The HP method for measuring WFD in one dimension is based on a three-rod arrangement, aligned in the direction of the flow (vertical for leaching). A heat pulse is released from a center rod and the temperature response is monitored with upstream (US) and downstream (DS) rods. Water moving through the soil caries heat with it, causing differences in temperature response at the US and DS locations. Appropriate theory (e.g., Ren et al., 2000) is then used to determine WFD from the differences in temperature response. In this study, we have constructed sensors with large probes and developed numerical and analytical solutions for approximating the measurement. One-dimensional flow experiments were conducted with WFD ranging between 50 and 700 cm per day. A numerical model was developed to mimic the measurements, and also served for the evaluation of the analytical solution. For estimation WFD, and analytical model was developed to approximate heat transfer in this setting. The analytical solution was based on the work of Knight et al. (2012) and Knight et al. (2016), which suggests that the finite properties of the rods can be captured to a large extent by assuming them to be cylindrical perfect conductors. We found that: (1) the sensor is sensitive for measuring WFD in the investigated range, (2) the numerical model well-represents the sensor measurement, and (2) the analytical approximation could be improved by accounting for water and heat flow divergence by the large rods.
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Meidan, Rina, and Robert Milvae. Regulation of Bovine Corpus Luteum Function. United States Department of Agriculture, March 1995. http://dx.doi.org/10.32747/1995.7604935.bard.
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The main goal of this research plan was to elucidate regulatory mechanisms controlling the development, function of the bovine corpus luteum (CL). The CL contains two different sterodigenic cell types and therefore it was necessary to obtain pure cell population. A system was developed in which granulosa and theca interna cells, isolated from a preovulatory follicle, acquired characteristics typical of large (LL) and small (SL) luteal cells, respectively, as judged by several biochemical and morphological criteria. Experiments were conducted to determine the effects of granulosa cells removal on subsequent CL function, the results obtained support the concept that granulosa cells make a substaintial contribution to the output of progesterone by the cyclic CL but may have a limited role in determining the functional lifespan of the CL. This experimental model was also used to better understand the contribution of follicular granulosa cells to subsequent luteal SCC mRNA expression. The mitochondrial cytochrome side-chain cleavage enzyme (SCC), which converts cholesterol to pregnenolone, is the first and rate-limiting enzyme of the steroidogenic pathway. Experiments were conducted to characterize the gene expression of P450scc in bovine CL. Levels of P450scc mRNA were higher during mid-luteal phase than in either the early or late luteal phases. PGF 2a injection decreased luteal P450scc mRNA in a time-dependent manner; levels were significantly reduced by 2h after treatment. CLs obtained from heifers on day 8 of the estrous cycle which had granulosa cells removed had a 45% reduction in the levels of mRNA for SCC enzymes as well as a 78% reduction in the numbers of LL cells. To characterize SCC expression in each steroidogenic cell type we utilized pure cell populations. Upon luteinization, LL expressed 2-3 fold higher amounts of both SCC enzymes mRNAs than SL. Moreover, eight days after stimulant removal, LL retained their P4 production capacity, expressed P450scc mRNA and contained this protein. In our attempts to establish the in vitro luteinization model, we had to select the prevulatory and pre-gonadotropin surge follicles. The ratio of estradiol:P4 which is often used was unreliable since P4 levels are high in atretic follicles and also in preovulatory post-gonadotropin follicles. We have therefore examined whether oxytocin (OT) levels in follicular fluids could enhance our ability to correctly and easily define follicular status. Based on E2 and OT concentrations in follicular fluids we could more accurately identify follicles that are preovulatory and post gonadotropin surge. Next we studied OT biosynthesis in granulosa cells, cells which were incubated with forskolin contained stores of the precursor indicating that forskolin (which mimics gonadotropin action) is an effective stimulator of OT biosynthesis and release. While studying in vitro luteinization, we noticed that IGF-I induced effects were not identical to those induced by insulin despite the fact that megadoses of insulin were used. This was the first indication that the cells may secrete IGF binding protein(s) which regonize IGFs and not insulin. In a detailed study involving several techniques, we characterized the species of IGF binding proteins secreted by luteal cells. The effects of exogenous polyunsaturated fatty acids and arachidonic acid on the production of P4 and prostanoids by dispersed bovine luteal cells was examined. The addition of eicosapentaenoic acid and arachidonic acid resulted in a dose-dependent reduction in basal and LH-stimulated biosynthesis of P4 and PGI2 and an increase in production of PGF 2a and 5-HETE production. Indomethacin, an inhibitor of arachidonic acid metabolism via the production of 5-HETE was unaffected. Results of these experiments suggest that the inhibitory effect of arachidonic acid on the biosynthesis of luteal P4 is due to either a direct action of arachidonic acid, or its conversion to 5-HETE via the lipoxgenase pathway of metabolism. The detailed and important information gained by the two labs elucidated the mode of action of factors crucially important to the function of the bovine CL. The data indicate that follicular granulosa cells make a major contribution to numbers of large luteal cells, OT and basal P4 production, as well as the content of cytochrome P450 scc. Granulosa-derived large luteal cells have distinct features: when luteinized, the cell no longer possesses LH receptors, its cAMP response is diminished yet P4 synthesis is sustained. This may imply that maintenance of P4 (even in the absence of a Luteotropic signal) during critical periods such as pregnancy recognition, is dependent on the proper luteinization and function of the large luteal cell.
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Castellano, Mike J., Abraham G. Shaviv, Raphael Linker, and Matt Liebman. Improving nitrogen availability indicators by emphasizing correlations between gross nitrogen mineralization and the quality and quantity of labile soil organic matter fractions. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7597926.bard.
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A major goal in Israeli and U.S. agroecosystems is to maximize nitrogen availability to crops while minimizing nitrogen losses to air and water resources. This goal has presented a significant challenge to global agronomists and scientists because crops require large inputs of nitrogen (N) fertilizer to maximize yield, but N fertilizers are easily lost to surrounding ecosystems where they contribute to water pollution and greenhouse gas concentrations. Determination of the optimum N fertilizer input is complex because the amount of N produced from soil organic matter varies with time, space and management. Indicators of soil N availability may help to guide requirements for N fertilizer inputs and are increasingly viewed as indicators of soil health To address these challenges and improve N availability indicators, project 4550 “Improving nitrogen availability indicators by emphasizing correlations between gross nitrogen mineralization and the quality and quantity of labile organic matter fractions” addressed the following objectives: Link the quantity and quality of labile soil organic matter fractions to indicators of soil fertility and environmental quality including: i) laboratory potential net N mineralization ii) in situ gross N mineralization iii) in situ N accumulation on ion exchange resins iv) crop uptake of N from mineralized soil organic matter sources (non-fertilizer N), and v) soil nitrate pool size. Evaluate and compare the potential for hot water extractable organic matter (HWEOM) and particulate organic matter quantity and quality to characterize soil N dynamics in biophysically variable Israeli and U.S. agroecosystems that are managed with different N fertility sources. Ultimately, we sought to determine if nitrogen availability indicators are the same for i) gross vs. potential net N mineralization processes, ii) diverse agroecosystems (Israel vs. US) and, iii) management strategies (organic vs. inorganic N fertility sources). Nitrogen availability indicators significantly differed for gross vs. potential N mineralization processes. These results highlight that different mechanisms control each process. Although most research on N availability indicators focuses on potential net N mineralization, new research highlights that gross N mineralization may better reflect plant N availability. Results from this project identify the use of ion exchange resin (IERs) beads as a potential technical advance to improve N mineralization assays and predictors of N availability. The IERs mimic the rhizosphere by protecting mineralized N from loss and immobilization. As a result, the IERs may save time and money by providing a measurement of N mineralization that is more similar to the costly and time consuming measurement of gross N mineralization. In further search of more accurate and cost-effective predictors of N dynamics, Excitation- Emission Matrix (EEM) spectroscopy analysis of HWEOM solution has the potential to provide reliable indicators for changes in HWEOM over time. These results demonstrated that conventional methods of labile soil organic matter quantity (HWEOM) coupled with new analyses (EEM) may be used to obtain more detailed information about N dynamics. Across Israeli and US soils with organic and inorganic based N fertility sources, multiple linear regression models were developed to predict gross and potential N mineralization. The use of N availability indicators is increasing as they are incorporated into soil health assessments and agroecosystem models that guide N inputs. Results from this project suggest that some soil variables can universally predict these important ecosystem process across diverse soils, climate and agronomic management. BARD Report - Project4550 Page 2 of 249