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Journal articles on the topic 'MMSNP'

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Author: Grafiati
Published: 22 June 2023

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1

Torabi, Mitra, Ayuob Aghanejad, Pouria Savadi, Abolfazl Barzegari, Yadollah Omidi, and Jaleh Barar. "Targeted Delivery of Sunitinib by MUC-1 Aptamer-Capped Magnetic Mesoporous Silica Nanoparticles." Molecules 28, no. 1 (January 3, 2023): 411. http://dx.doi.org/10.3390/molecules28010411.

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Magnetic mesoporous silica nanoparticles (MMSNPs) are being widely investigated as multifunctional novel drug delivery systems (DDSs) and play an important role in targeted therapy. Here, magnetic cores were synthesized using the thermal decomposition method. Further, to improve the biocompatibility and pharmacokinetic behavior, mesoporous silica was synthesized using the sol-gel process to coat the magnetic cores. Subsequently, sunitinib (SUN) was loaded into the MMSNPs, and the particles were armed with amine-modified mucin 1 (MUC-1) aptamers. The MMSNPs were characterized using FT-IR, TEM, SEM, electrophoresis gel, DLS, and EDX. MTT assay, flow cytometry analysis, ROS assessment, and mitochondrial membrane potential analysis evaluated the nanoparticles’ biological impacts. The physicochemical analysis revealed that the engineered MMSNPs have a smooth surface and spherical shape with an average size of 97.6 nm. The biological in vitro analysis confirmed the highest impacts of the targeted MMSNPs in MUC-1 overexpressing cells (OVCAR-3) compared to the MUC-1 negative MDA-MB-231 cells. In conclusion, the synthesized MMSNP-SUN-MUC-1 nanosystem serves as a unique multifunctional targeted delivery system to combat the MUC-1 overexpressing ovarian cancer cells.
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2

Bodirsky, Manuel, Hubie Chen, and Tomás Feder. "On the Complexity of MMSNP." SIAM Journal on Discrete Mathematics 26, no. 1 (January 2012): 404–14. http://dx.doi.org/10.1137/090778493.

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3

Kun, Gábor. "Constraints, MMSNP and expander relational structures." Combinatorica 33, no. 3 (June 2013): 335–47. http://dx.doi.org/10.1007/s00493-013-2405-4.

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4

Kong, Yihan, Xue Li, Xiaojing Liu, Jingjing Pang, Xinling Mu, and Wei Liu. "Galactosylated Chitosan Modified Magnetic Mesoporous Silica Nanoparticles Loaded with Nedaplatin for the Targeted Chemo-Photothermal Synergistic Therapy of Cancer." Journal of Nanoscience and Nanotechnology 21, no. 9 (September 1, 2021): 4553–64. http://dx.doi.org/10.1166/jnn.2021.19142.

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The use of chemotherapy combined with photothermal therapy (PTT) is getting a focus topic for cancer treatment. Duing this research, the double targeting drug delivery system of nedaplatin (NDP)–carboxyl-functionalized magnetic mesoporous silica (MMSN-COOH)–galactosylated chitosan (GC) nanoparticles (NPs) was constructed. Because MMSNs have special physical properties, it can target to the specific area. In addition, it’s able to convert absorbed near-infrared (NIR) light into heat energy for photothermal therapy (PTT). Furthermore, the thermal energy generated by MMSNs under NIR lasers can accelerate the release of drug from preparations. Moreover, GC modified MMSNs-COOH as a carrier can increase the drug uptake of cancer cells that highly express galectins in vitro, resulting in cancer cell apoptosis, and thus increasing the targeting of cancerous tissue in vivo. The experimental consequences in vitro and in vivo revealed that the NDP@MMSNCOOH-GC NPs combined with PTT could avoid systemic toxicity and improve biosecurity while having good anticancer effect.
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Li, Wen, Fang Li, Yang Zhang, Hongtao Ren, Xing Bao, Zhongwei Wang, and Yali Wang. "X-Linked Inhibitor of Apoptosis Protein (XIAP)-Loaded Magnetic Mesoporous Silica Nanoparticles Incorporated with miR-233 to Improve Radio Sensitization of Cervical Cancer Cells and Promote Apoptosis." Journal of Biomedical Nanotechnology 18, no. 3 (March 1, 2022): 747–53. http://dx.doi.org/10.1166/jbn.2022.3281.

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This study investigated the impact of magnetic mesoporous silica nanoparticles (MMSN)-encapsulated X-linked inhibitor of apoptosis protein (XIAP) and miR-233 on tumor microenvironment in cervical cancer, to provide targeted treatment and strategy, to improve radio sensitization of cancer cells. Cervical cancer cells were treated with normal saline (control group), XIAP-loaded metallic mesoporous silica nanoparticles (MMSNs), and miR-233-targeted material (XIAP group, XIAP+miR-233 group). Proliferation, apoptosis and colony forming ability of cancer cells were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method, flow cytometry and colony formation experiments. In vivo experiments were established to observe the impact of XIAP-loaded MMSNs and miR-233 on tumor growth. Administration of XIAP-loaded MMSNs suppressed tumor growth of cervical cancer, and presence of miR-233 targeted material further decreased tumor volume, increasing radio sensitization of cancer cells. In vitro experiments confirmed that, combined treatment of XIAP and miR-233 suppressed cancer cell proliferation and invasion when inducing apoptosis. XIAP MMSNs characterized by large unit surface area, high dispersion and adhesion, and prolonged circulation time, improving drug delivery and treatment selectivity of chemotherapeutic drugs. This study suggests that XIAP MMSNs with miR-233 material suppress cervical cancer cell progression and tumor growth when augmenting radiosensitization of cancer cells, providing evidence for targeted therapy for the disease.
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6

Zhang, Jin, and Dianping Tang. "4-Nitrophenol-Loaded Magnetic Mesoporous Silica Hybrid Materials for Spectrometric Aptasensing of Carcinoembryonic Antigen." Micromachines 12, no. 10 (September 22, 2021): 1138. http://dx.doi.org/10.3390/mi12101138.

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Aptamer- or antibody-based sensing protocols have been reported for detecting carcinoembryonic antigen (CEA), but most exhibit complicated procedures or multiple reactions. In this work, we developed a one-step aptasensing protocol for the spectrometric determination of CEA based on 4-nitrophenol (4-NP)-loaded magnetic mesoporous silica nanohybrids (MMSNs) for bioresponsive controlled-release applications. To fabricate such a responsive–controlled sensing system, single-stranded complementary oligonucleotides relative to the CEA-specific aptamer were first modified on the aminated MMSN. Thereafter, 4-NP molecules blocked the pores with the assistance of the aptamers via a hybridization reaction. The introduced target CEA specifically reacted with the hybridized aptamer, thus detaching from the MMSN to open the gate. The loaded 4-NP molecules were released from the pores, as determined using ultraviolet–visible (UV–vis) absorption spectroscopy after magnetic separation. Under optimum conditions, the absorbance increased with an increase in the target CEA in the sample and exhibited a good linear relationship within the dynamic range of 0.1–100 ng mL−1, with a detection limit of 46 pg mL−1. Moreover, this system also displayed high specificity, good reproducibility, and acceptable accuracy for analyzing human serum specimens, in comparison with a commercialized human CEA-enzyme-linked immunosorbent assay (ELISA) kit.
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7

Hartanto, Bernadus Agus, Jafron Wasiq Hidayat, and Bambang Waluyo Hadi Eko Prasetiyono. "The Role of Institution Related to Conservation Area of Merbabu Mountain National Park in Boyolali District." E3S Web of Conferences 125 (2019): 01017. http://dx.doi.org/10.1051/e3sconf/201912501017.

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Conservation areas including Mount Merbabu National Park (MMNP) that have social, economic and ecological benefits both for the local and global environment need attention and support not only for MMNP office but also for the integration of the roles of parties related institutionally. The objective of the present study was to obtain the information about the involvement and integration of the roles of related institutions to support the conservation of the MMNP area in Boyolali District. The method is used literature review. The results shows that the role of various related institutions in MMNP conservation still varied. The local government, community institutions and other institutions do not have a continuous program in supporting conservation MMNP. Integration of related institutional roles in supporting the preservation of MMNP area through the compilation of conservation regulations that were followed up with the village regulation at buffer zone MMNP, Extension of MMNP conservation to all levels of society, especially at the school level, Integration of tourism development within and outside the MMNP area, Integration of community empowerment programs in and around the MMNP area, Mitigation of MMNP disturbances and disasters integratively.
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8

Li, Yi-Shao, Pei-Chun Liao, Chung-Te Chang, and Shih-Ying Hwang. "The Contribution of Epigenetics to Evolutionary Adaptation in Zingiber kawagoii Hayata (Zingiberaceae) Endemic to Taiwan." Plants 12, no. 7 (April 4, 2023): 1558. http://dx.doi.org/10.3390/plants12071558.

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We epigenotyped 211 individuals from 17 Zingiber kawagoii populations using methylation-sensitive amplification polymorphism (MSAP) and investigated the associations of methylated (mMSAP) and unmethylated (uMSAP) loci with 16 environmental variables. Data regarding genetic variation based on amplified fragment length polymorphism (AFLP) were obtained from an earlier study. We found a significant positive correlation between genetic and epigenetic variation. Significantly higher mean mMSAP and uMSAP uHE (unbiased expected heterozygosity: 0.223 and 0.131, respectively, p < 0.001) per locus than that estimated based on AFLP (uHE = 0.104) were found. Genome scans detected 10 mMSAP and 9 uMSAP FST outliers associated with various environmental variables. A significant linear fit for 11 and 12 environmental variables with outlier mMSAP and uMSAP ordination, respectively, generated using full model redundancy analysis (RDA) was found. When conditioned on geography, partial RDA revealed that five and six environmental variables, respectively, were the most important variables influencing outlier mMSAP and uMSAP variation. We found higher genetic (average FST = 0.298) than epigenetic (mMSAP and uMSAP average FST = 0.044 and 0.106, respectively) differentiation and higher genetic isolation-by-distance (IBD) than epigenetic IBD. Strong epigenetic isolation-by-environment (IBE) was found, particularly based on the outlier data, controlling either for geography (mMSAP and uMSAP βE = 0.128 and 0.132, respectively, p = 0.001) or for genetic structure (mMSAP and uMSAP βE = 0.105 and 0.136, respectively, p = 0.001). Our results suggest that epigenetic variants can be substrates for natural selection linked to environmental variables and complement genetic changes in the adaptive evolution of Z. kawagoii populations.
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9

Zackrisson, Sophia, Lars Janzon, Jonas Manjer, and Ingvar Andersson. "Improved survival rate for women with interval breast cancer – results from the breast cancer screening programme in Malmö, Sweden 1976–1999." Journal of Medical Screening 14, no. 3 (September 1, 2007): 138–43. http://dx.doi.org/10.1258/096914107782066239.

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Objective: Breast cancers detected between screening examinations can influence the sensitivity of a screening programme. Studies of the prognosis of these so-called interval breast cancers show diverging results. We investigated the course of interval breast cancer over time in the Malmö Mammographic Screening Trial (MMST) 1976–86 and the Malmö Mammographic Service Screening Programme (MMSSP) 1990–99. Material and methods: Stage distribution and survival of interval cancers in MMSSP were compared with screen-detected and non-attender cancer cases in MMSSP, with interval cancers in MMST and with breast cancer cases in a non-screened population five years before the start of MMSSP (pre-screening cancer cases). Results: In MMSSP 1990–99, the interval cancers did not differ in stage distribution or survival compared with cancer cases in non-attenders, while screen-detected cancer cases had more favourable stage distribution and rate of survival than had the interval cancer cases. The MMST interval cancer cases, 1976–1986, had more favourable stage distribution but higher overall case fatality rate, relative risks (RR) 1.78 (1.00–3.20), and breast cancer case fatality rate, RR 2.05 (1.05–4.00), compared with the more recent MMSSP interval cancer cases. No significant difference in five-year survival was seen in the MMSSP interval cancer cases compared with pre-screening cancer cases not exposed to screening. Conclusion: In this urban population invited to mammographic screening, the survival rate for women with interval cancer has improved over a period of 20 years. Further studies are needed to assess what factors might explain changes in the course of interval breast cancer.
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10

Liu, Min-Chao, Bing Liu, Xian-Li Chen, Hui-Chao Lin, Xiang-Yu Sun, Jia-Zheng Lu, Yan-Yu Li, Si-Qi Yan, Lu-Yong Zhang, and Ping Zhao. "Calcium carbonate end-capped, folate-mediated Fe3O4@mSiO2 core-shell nanocarriers as targeted controlled-release drug delivery system." Journal of Biomaterials Applications 32, no. 8 (January 22, 2018): 1090–104. http://dx.doi.org/10.1177/0885328217752994.

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Magnetic mesoporous silica nanospheres (MMSN) were prepared and the surface was modified with cancer cell-specific ligand folic acid. Calcium carbonate was then employed as acid-activated gatekeepers to cap the mesopores of the MMSN, namely, MMSN-FA-CaCO3. The formation of the MMSN-FA-CaCO3 was proved by several characterization techniques, viz. transmission electron microscopy, zeta potential measurement, Fourier transform infrared spectroscopy, BET surface area measurement, and UV–Vis spectroscopy. Daunomycin was successfully loaded in the MMSN-FA-CaCO3 and the system exhibited sensitive pH stimuli-responsive release characteristics under blood or tumor microenvironment. Cellular uptake by folate receptor (FR)-overexpressing HeLa cells of the MMSN-FA-CaCO3 was higher than that by non-folated-conjugated ones. Intracellular-uptake studies revealed preferential uptake of these nanoparticles into FR-positive [FR(+)] HeLa than FR-negative [FR(-)]A549 cell lines. DAPI stain experiment showed high apoptotic rate of MMSN-FA-DNM-CaCO3 to HeLa cells. The present data suggest that the CaCO3 coating and folic acid modification of MMSN are able to create a targeted, pH-sensitive template for drug delivery system with application in cancer therapy.
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11

Crossley, Nick, and Gemma Edwards. "Cases, Mechanisms and the Real: The Theory and Methodology of Mixed-Method Social Network Analysis." Sociological Research Online 21, no. 2 (May 2016): 217–85. http://dx.doi.org/10.5153/sro.3920.

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In this paper we make a methodological case for mixed method social network analysis (MMSNA). We begin by both challenging the idea, prevalent in some quarters, that mixing methods means combining incompatible epistemological or theoretical assumptions and by positing an ontological argument in favour of mixed methods. We then suggest a methodological framework for MMSNA and argue for the importance of ‘mechanisms’ in relational-sociological research. Finally, we discuss two examples of MMSNA from our own research, using them to illustrate arguments from the paper.
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12

Froehlich, Dominik E., Sara Van Waes, and Hannah Schäfer. "Linking Quantitative and Qualitative Network Approaches: A Review of Mixed Methods Social Network Analysis in Education Research." Review of Research in Education 44, no. 1 (March 2020): 244–68. http://dx.doi.org/10.3102/0091732x20903311.

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Social network analysis (SNA) is becoming a prevalent method in education research and practice. But criticism has been voiced against the heavy reliance on quantification within SNA. Recent work suggests combining quantitative and qualitative approaches in SNA—mixed methods social network analysis (MMSNA)—as a remedy. MMSNA is helpful for addressing research questions related to the formal or structural side of relationships and networks, but it also attends to more qualitative questions such as the meaning of interactions or the variability of social relationships. In this chapter, we describe how researchers have applied and presented MMSNA in publications from the perspective of general mixed methods research. Based on a systematic review, we summarize the different applications within the field of education and learning research, point to potential shortcomings of the methods and its presentation, and develop an agenda to support researchers in conducting future MMSNA research.
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13

Kusumaningrum, Lia, Prabang Setyono, Muhammad Amin Sunarhadi, Muchammad Sholiqin, Bagus Hermawan, and Gavriel Enos Berlin. "Analysis of Diversity Level and Vegetation Structural Composition Post Restoration at Resort Cangkringan Mount Merapi National Park." IOP Conference Series: Earth and Environmental Science 1098, no. 1 (October 1, 2022): 012033. http://dx.doi.org/10.1088/1755-1315/1098/1/012033.

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Abstract Mount Merapi eruption in 2010 caused a total of 1,128 ha of damage to Mount Merapi National Park (MMNP). The MMNP Center carried out planting activities as a restoration activity in an area that had a fairly severe impact on Cangkringan Resort. This research is located at Cangkringan Resort in the restoration area of Klangon and Kali Kuning. This study aims to determine the level of diversity and vegetation structure after 10 years of post restoration. Analysis of the composition and structure is important to assess biodiversity and determine the success rate of restoration of the MMNP ecosystem damaged by the eruption. This research uses the line and line transect method with quantitative data analysis by Shanon Weiner and Evenness. This study found 45 plant species in Klangon and 34 plant species in Kali Kuning. The results show that the total level of diversity in Cangkringan Resort MMNP is moderate (1.465), the level of evenness in Klangon is moderate (0.444) and in Kali Kuning moderate (0.346). Therefore, the level of diversity and uniformity of the vegetation at Cangkringan Resort MMNP is at the medium classification level and shows a better change in the improvement of the vegetation.
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Weng, Jian Jun, Yang Zhou, and Wei Su. "Study on the Management Mode of Seaplane Navigation Safety." Advanced Materials Research 1030-1032 (September 2014): 2634–38. http://dx.doi.org/10.4028/www.scientific.net/amr.1030-1032.2634.

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Seaplanes are seemed as ships when they are on the water surface. The first civil seaplane project was carried out in China in the year of 2012. Therefore, the management modes and regulations for seaplane navigation safety are to be studied. Starting from the characteristics of seaplane and its special requirement on navigation safety management, the three dimension (3D) structure for the Management Mode of Seaplane Navigation Safety (MMSNS) is designed based on the Hall 3D structure in System Engineering, together with its model structure. Accordingly, MMSNS is established and its composition is analyzed.
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Lu, Minghua. "Bioresponsive-controlled release of methylene blue from magnetic mesoporous silica from the electrochemical detection of telomerase activity." Analyst 142, no. 18 (2017): 3477–83. http://dx.doi.org/10.1039/c7an01127j.

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16

Danci, Oana. "Management of Alluvial Forests Included in Natura 2000 91E0* Habitat Type in Maramureş Mountains Nature Park." Transylvanian Review of Systematical and Ecological Research 17, no. 1 (June 1, 2015): 163–76. http://dx.doi.org/10.1515/trser-2015-0057.

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Abstract The Natura 2000 habitat type 91E0* Alluvial forests of Alnus glutinosa and Fraxinus excelsior (Alno-Padion, Alnion incanae, Salicion albae) include three subtypes of forests. In the Maramureș Mountains Nature Park (MMNP) the alluvial forests are represented by Alnus incana forest situated on the banks of mountain rivers. Starting from 2007, 70% of the MMNP is also a Natura 2000 site of community interest. In the standard form for the site are listed 18 Natura 2000 habitat types, but that of alluvial forests 91E0* is not listed either due to an error or lack of available research data. Our study seeks to provide information regarding this high conservation value habitat such as: structure, distribution,managementmeasures andmonitoring protocol. The purpose of this paper is to offer a management tool for this conservation value habitat which is also exposed to human impact more than any other priority habitat in MMNP.
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17

Sweke, Emmanuel Andrew, Julius Michael Assam, Abdillahi Ismail Chande, Athanasio Stephano Mbonde, Magnus Mosha, and Abel Mtui. "Comparing the Performance of Protected and Unprotected Areas in Conserving Freshwater Fish Abundance and Biodiversity in Lake Tanganyika, Tanzania." International Journal of Ecology 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/7139689.

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Marine protected areas have been shown to conserve aquatic resources including fish, but few studies have been conducted of protected areas in freshwater environments. This is particularly true of Lake Tanganyika, Tanzania. To better conserve the lake’s biodiversity, an understanding of the role played by protected areas in conserving fish abundance and diversity is needed. Sampling of fish and environmental parameters was performed within the Mahale Mountains National Park (MMNP) and nearby unprotected areas at depths between 5 m and 10 m. Twelve replicates of fish sampling were performed at each site using gillnets set perpendicularly to the shore. Mann-Whitney tests were performed, and the total amount of species turnover was calculated. A total of 518 individual fish from 57 species were recorded in the survey. The fish weight abundance was fivefold greater in the MMNP than in the unprotected areas. Fish abundance and diversity were higher in the MMNP than in the unprotected areas and decreased with distance from it. Our findings confirmed the importance of the protected area in conserving fish resources in Lake Tanganyika. The study provides baseline information for management of the resources and guiding future studies in the lake and other related ecosystems. Management approaches that foster awareness and engage with communities surrounding the MMNP are recommended for successful conservation of the resources in the region.
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18

Keshavarz, Hasan, Alireza Khavandi, Somaye Alamolhoda, and M. Reza Naimi-Jamal. "Magnetite mesoporous silica nanoparticles embedded in carboxybetaine methacrylate for application in hyperthermia and drug delivery." New Journal of Chemistry 44, no. 20 (2020): 8232–40. http://dx.doi.org/10.1039/d0nj00939c.

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19

Meng, Lihui, Qingwang Liu, Jigang Wang, Zhenzhong Fan, and Xiaoming Wei. "Hydrophobic mesoporous silicon dioxide for improving foam stability." RSC Advances 10, no. 32 (2020): 18565–71. http://dx.doi.org/10.1039/d0ra02161j.

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20

Knežević, Nikola Ž. "Magnetic Field-Induced Accentuation of Drug Release from Core/Shell Magnetic Mesoporous Silica Nanoparticles for Anticancer Treatment." Journal of Nanoscience and Nanotechnology 16, no. 4 (April 1, 2016): 4195–99. http://dx.doi.org/10.1166/jnn.2016.11762.

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Drug (9-aminoacridine) loaded core/shell magnetic iron oxide-containing mesoporous silica nanoparticles (MMSN) were treated with HeLa cells and the drug carriers were agitated by exposure to magnetic field. Viability studies show the applicability of drug loaded magnetic material for anticancer treatment, which is enhanced upon stimulation with magnetic field. Confocal micrographs of fluorescein grafted MMSN-treated HeLa cells confirmed the ability of magnetic field to concentrate the synthesized material in the exposed area of the cells. The synthesized material and the applied drug delivery method may find application in magnetic field-responsive targeted treatment of cancer.
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21

Jung, Dietrich. "Modern Muslim Subjectivities: Religion and Multiple Modernities within Islam." Numen 66, no. 4 (June 18, 2019): 339–59. http://dx.doi.org/10.1163/15685276-12341543.

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AbstractThis article presents the overarching theoretical framework and some tentative findings of the Modern Muslim Subjectivities Project (MMSP). It discusses some of its conceptual tools and presents strategies for studying the role of religion in modern Muslim subjectivity formation. The core rationale of this research program is to explore the role of religious traditions in the construction of modern forms of Muslim subjectivity and social order. It investigates the ways in which Muslims have imagined specifically Islamic modernities in combination with non-religious and globally relevant cultural scripts. In criticizing the alleged Western origin and secular nature of modernity, the MMSP aims at making original contributions both to conceptual discussions of modernity in the study of religions and to our knowledge of modern Muslim societies.
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Lluch Canut, María Teresa. "Salud Mental Positiva. Cuidar la Salud Mental Positiva, en el contexto de la pandemia COVID-19 y hacía un futuro denominado “nueva normalidad”." Hermeneutic, no. 19 (March 24, 2021): 8–22. http://dx.doi.org/10.22305/hermeneutic-unpa.n19.a2021.763.

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El objetivo general de este artículo es el de compartir conocimientos entorno a la Salud Mental Positiva y reflexiones de su importancia en el contexto actual de pandemia COVID-19 y hacía un futuro inmediato denominado “nueva normalidad”. Tras una introducción, se desarrolla una definición básica de Salud Mental Positiva (SMP) que permite identificar la necesidad de aceptar como mentalmente saludable pensamientos, sentimientos y comportamientos positivos y negativos. Pero se detallan de forma relevante los indicadores límite de alerta de Salud Mental Positiva, a los que hay que prestar especial atención y pedir ayuda si es necesario: duración, intensidad, frecuencia, diferencia en el patrón habitual de respuesta, y consecuencias. Posteriormente, se describe el Modelo Multifactorial de Salud Mental Positiva-MMSMP de Lluch Canut (1999), que concibe la SMP como un constructo configurado por 6 factores: Satisfacción Personal (F1), Actitud Prosocial (F2), Autocontrol (F3), Autonomía (F4), Resolución de Problemas y Autoactualización (F5) y Habilidades de Relación Interpersonal (F6). El MMSMP se evalúa mediante un cuestionario creado por la misma autora (Cuestionario de Salud Mental Positiva-CSMP) constituido por 39 ítems, distribuidos de forma desigual entre los 6 factores del modelo MMSMP. Se citan diversos estudios vinculados al tema, tanto a nivel de investigaciones psicométricas, como estudios correlacionales y programas de intervención para la promoción y la prevención de la Salud Mental Positiva, en diversas poblaciones (estudiantes universitarios, personas con problemas crónicos de salud física, cuidadoras de personas con problemas crónicos de salud física y/o mental, entre otros). También se describen estrategias para cuidar la Salud Mental Positiva, en base a Decálogos, adaptados a la situación específica de pandemia COVID-19. Y por último se exponen unas reflexiones a modo de conclusiones, en dos puntos principales: la Salud Mental Positiva en el contexto de desarrollo existencial, y la Salud Mental Positiva y el Sufrimiento Emocional.
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Kusumaningrum, Lia, and Rinoa Salsabila Izdihar. "Potential Carbon Storage In The Forest Area Of Mount Merbabu National Park (MMbNP) Resort Selo Central Java." IOP Conference Series: Earth and Environmental Science 1098, no. 1 (October 1, 2022): 012055. http://dx.doi.org/10.1088/1755-1315/1098/1/012055.

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Abstract Forests play a very large function in the solution of climate problems. Trees are capable of absorbing carbon dioxide (CO2) in the photosynthesis process and store it in the form of biomass, thereby reducing the concentration of carbon in the atmosphere. The forest area of Mount Merbabu National Park (MMbNP) has great potential to absorb carbon emissions and mitigate climate. The purpose of this study was to determine the potential for carbon storage in MMbNP. The research method used is quantitative descriptive and analyzed by allometric method adapted to tree species at low, medium, and high densities. The estimated carbon storage refers to the Indonesian National Standard (SNI) 7724 of 2011. The potential for total carbon storage in the forest area is 129.357,71 tons. In detail, the total carbon storage in low density land cover types is 10.201,87 tons, medium density is 23.729.66 tons, and high density is 95.426,18 tons. This type of land cover with high density has the highest carbon absorption capacity; this is relevant to the presence of the number of trees that are able to absorb more carbon and have a larger area than other types of land cover.
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Jung, Dietrich. "The Formation of Modern Muslim Subjectivities: Research Project and Analytical Strategy." Tidsskrift for Islamforskning 11, no. 1 (December 19, 2017): 11. http://dx.doi.org/10.7146/tifo.v11i1.102870.

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This article introduces research questions, theoretical premises and analytical tools on which the Modern Muslim Subjectivities Project (MMSP) builds. The project takes its point of departure in sociological theories on the formation of modern forms of subjectivity and applies these to the Muslim world. The present article discusses three theories in particular: Theories on multiple modernities, theories on successive modernities and post-structuralist approaches to the formation of modern subjectivities. The hypothesis of the project – and thereby the hypothesis of the present article – is that the mentioned so-called “Western” theories can be used in our analyses and understanding of the modern Muslim world as well. The article presents this argument in three steps and illustrates the theoretical discussions with examples from the different subprojects carried out within the shared frame of the MMSP.Denne artikel præsenterer de forskningsspørgsmål, teoretiske præmisser og analytiske redskaber, som The Modern Muslim Subjectivities Project (MMSP) bygger på. Projektet tager udgangspunkt i sociologiske teorier om dannelsen af moderne former for subjektivitet og anvender dem i forhold til den muslimske verden. Nærværende artikel diskuterer især tre teoretiske kilder: teorier om mangfoldige moderniteter (multiple modernities), teorier om fortløbende moderniteter (successive modernities) og poststrukturalistiske tilgange til dannelse af moderne subjektiviteter. Projektets og dermed også artiklens hypotese er, at disse såkaldte “vestlige” teorier også kan bruges i vores forståelse af den moderne muslimske verden. Artiklen fremlægger dette argument i tre trin og illustrerer de teoretiske diskussioner med eksempler fra de forskellige delprojekter, som bliver gennemført inden for den fælles forskningsramme i MMSP.
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Ruimy, Anne, and Vitaly Volpert. "Editorial." Mathematical Modelling of Natural Phenomena 15 (2020): E1. http://dx.doi.org/10.1051/mmnp/2019047.

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We are pleased to announce to the authors and readers of Mathematical Modelling of Natural Phenomena (MMNP) a number of changes for 2020. These changes concern: the indexing of the journal, the format of publication, and the structure of the editorial board.
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Liang, Yucang, and Martin Meixner. "Organoindium-modified monodisperse ellipsoid-/platelet-like periodic mesoporous silicas." Dalton Transactions 46, no. 23 (2017): 7495–505. http://dx.doi.org/10.1039/c7dt01132f.

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Indium-modified mondisperse ellipsoid-/platelet-like large-pore periodic mesoporous silica nanoparticles (MMSNs) SBA-15 have been prepared via molecular grafting of In[N(SiMe3)2]3. Surface ligand exchange led to the formation of heteroleptic In species, and the resulting surface In species were converted into crystalline In2O3 nanoparticles by calcination.
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Esthi, R. B., N. C. Irawan, and I. Setiawan. "The nexus between ecological competence, forest area management, and sustainable agroecosystem performance for communities around Mount Merbabu National Park (MMbNP)." IOP Conference Series: Earth and Environmental Science 1108, no. 1 (November 1, 2022): 012019. http://dx.doi.org/10.1088/1755-1315/1108/1/012019.

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Abstract MMbNP, with an area of approximately 5,725 hectares through several regulations, is designated as a conservation area and limits human activities to preserve agroecosystems and support natural and cultural tourism activities. MMbNP has the potential to provide food and a source of income for people living around the area, but the intersections that occur cause social, economic, and ecological conflicts of interest. This study aims to determine the relationship between ecological competence, forest area management, and sustainable agroecosystem performance. With a total of 60 respondents, this study used purposive location selection methods and snowballed random sampling to determine the sample size. The data analysis examination uses a partial least square and a descriptive-analytical method. The results of the study state that ecological competence is significant for forest area management. Forest area management has a significant effect on sustainable agroecosystem performance. Environmental competence significantly affects the performance of sustainable agroecosystems through forest area management. The conclusion is that implementing systematic and comprehensive management stimulates the community’s active participation in silviculture and biodiversity and increases environmental competence. The performance of sustainable agroecosystems strengthens the role of government, the local economy, health and nutrition, community and culture, and also promotes environmental conservation.
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Chitayat, Adrienne B., Serge A. Wich, Matthew Lewis, Fiona A. Stewart, and Alex K. Piel. "Ecological correlates of chimpanzee (Pan troglodytes schweinfurthii) density in Mahale Mountains National Park, Tanzania." PLOS ONE 16, no. 2 (February 12, 2021): e0246628. http://dx.doi.org/10.1371/journal.pone.0246628.

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Understanding the ecological factors that drive animal density patterns in time and space is key to devising effective conservation strategies. In Tanzania, most chimpanzees (~75%) live outside national parks where human activities threaten their habitat’s integrity and connectivity. Mahale Mountains National Park (MMNP), therefore, is a critical area for chimpanzees (Pan troglodytes schweinfurthii) in the region due to its location and protective status. Yet, despite its importance and long history of chimpanzee research (>50 years), a park-wide census of the species has never been conducted. The park is categorized as a savanna-woodland mosaic, interspersed with riparian forest, wooded grassland, and bamboo thicket. This heterogeneous landscape offers an excellent opportunity to assess the ecological characteristics associated with chimpanzee density, a topic still disputed, which could improve conservation plans that protect crucial chimpanzee habitat outside the park. We examined the influence of fine-scale vegetative characteristics and topographical features on chimpanzee nest density, modeling nest counts using hierarchical distance sampling. We counted 335 nests in forest and woodland habitats across 102 transects in 13 survey sites. Nests were disproportionately found more in or near evergreen forests, on steep slopes, and in feeding tree species. We calculated chimpanzee density in MMNP to be 0.23 ind/km2, although density varied substantially among sites (0.09–3.43 ind/km2). Density was associated with factors related to the availability of food and nesting trees, with topographic heterogeneity and the total basal area of feeding tree species identified as significant positive predictors. Species-rich habitats and floristic diversity likely play a principal role in shaping chimpanzee density within a predominately open landscape with low food abundance. Our results provide valuable baseline data for future monitoring efforts in MMNP and enhance our understanding of this endangered species’ density and distribution across Tanzania.
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Haryadi, Haryadi, Sunarto Sunarto, and Sugiyarto Sugiyarto. "Vegetation Analysis of the Secondary Forest Area of ​​Mount Merapi National Park." Jurnal Biodjati 4, no. 1 (May 28, 2019): 50–57. http://dx.doi.org/10.15575/biodjati.v4i1.4239.

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Mount Merapi National Park (MMNP) is a natural con-servation area with the main function of preserving the diversity of plants, animals and their ecosystems. In 2010, Mount Merapi suffered a large eruption which caused damage to the forest ecosystem inside. One of the locations that suffered severe damage was at Cangkrin-gan Resort. After the eruption, the affected vegetation began to grow again. The purpose of this study is to monitor and determine the di-versity of secondary forest plants in the MMNP area. The method used was a method of path and use a point-intercept transect as the sam-pling unit. The results showed that after the eruption, the Acacia de-curens dominated at each level starting from sapling, poles and trees. Based on the results of the study showed that the eruption of Mount Merapi that occurred in 2010 resulted in a change in vegetation struc-ture in the area with the Shannon-Weiner diversity index which is still low, amounting to 1.86 for seedling, 1.32 for the sapling and 0.22 for poles. At the tree level 100% is still dominated by Acacia decurens.
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30

Helal-Neto, Edward, Aline Oliveira da Silva de Barros, Roberta Saldanha-Gama, Renata Brandão-Costa, Luciana Magalhães Rebêlo Alencar, Clenilton Costa dos Santos, Ramón Martínez-Máñez, et al. "Molecular and Cellular Risk Assessment of Healthy Human Cells and Cancer Human Cells Exposed to Nanoparticles." International Journal of Molecular Sciences 21, no. 1 (December 28, 2019): 230. http://dx.doi.org/10.3390/ijms21010230.

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Nanodrugs have in recent years been a subject of great debate. In 2017 alone, almost 50 nanodrugs were approved for clinical use worldwide. Despite the advantages related to nanodrugs/nanomedicine, there is still a lack of information regarding the biological safety, as the real behavior of these nanodrugs in the body. In order to better understand these aspects, in this study, we evaluated the effect of polylactic acid (PLA) nanoparticles (NPs) and magnetic core mesoporous silica nanoparticles (MMSN), of 1000 nm and 50 nm, respectively, on human cells. In this direction we evaluated the cell cycle, cytochemistry, proliferation and tubulogenesis on tumor cells lines: from melanoma (MV3), breast cancer (MCF-7, MDA-MB-213), glioma (U373MG), prostate (PC3), gastric (AGS) and colon adenocarcinoma (HT-29) and non-tumor cell lines: from human melanocyte (NGM), fibroblast (FGH) and endothelial (HUVEC), respectively. The data showed that an acute exposure to both, polymeric nanoparticles or MMSN, did not show any relevant toxic effects on neither tumor cells nor non-tumor cells, suggesting that although nanodrugs may present unrevealed aspects, under acute exposition to human cells they are harmless.
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Prasetyo, Lugas, and Ambar Kusumandari. "The potency of water availability and its use by the community around the Mount Merbabu National Park." E3S Web of Conferences 325 (2021): 02003. http://dx.doi.org/10.1051/e3sconf/202132502003.

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Water is one of the basic needs for every living thing, including humans. This study aims to determine the availability of water in the two springs, the utilization of water by the community around MMNP, the vegetation characteristics of the spring catchment areas, and the Water Use Index (WUI). Data of water availability was taken using the volumetric method. Water utilization by the community is collected by doing the interviews with the respondents. The vegetation characteristics is analyzed based on the vegetation density by using the NDVI method. Meanwhile, the Water Use Index (WUI) is obtained from a comparison between water demand and water supply. The results showed that the water debit available in the Tuk Simuncar and Tuk sipendok was 23.22 liters/second and 31.20 liters/second which were classified as class IV. The area of Tuk simuncar is dominated by high density vegetation (75 Ha), while Tuk Sipendok is dominated by moderate density vegetation (102.28 Ha). The community around MMNP uses 211 liters of water for household needs, 59 liters for livestock, and 10 liters for agriculture. The Water Use Index (WUA) of the two springs has a value of 0.3 which is included in the low level.
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Hao, Yue, Shu Bai, Linling Yu, and Yan Sun. "Magnetically Driven Muco-Inert Janus Nanovehicles for Enhanced Mucus Penetration and Cellular Uptake." Molecules 27, no. 21 (October 27, 2022): 7291. http://dx.doi.org/10.3390/molecules27217291.

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One of the main challenges of transmucosal drug delivery is that of enabling particles and molecules to move across the mucosal barrier of the mucosal epithelial surface. Inspired by nanovehicles and mucus-penetrating nanoparticles, a magnetically driven, mucus-inert Janus-type nanovehicle (Janus-MMSN-pCB) was fabricated by coating the zwitterionic polymer poly(carboxybetaine methacrylate) (pCB) on the mesoporous silica nanorod, which was grown on one side of superparamagnetic Fe3O4 nanoparticle using the sol–gel method. X-ray diffraction, transmission electron microscopy, vibrating sample magnetometry, and Fourier infrared spectroscopy were used to characterize the structure and morphology of the nanovehicles, proving the success of each synthesis step. The in vitro cell viability assessment of these composites using Calu-3 cell lines indicates that the nanovehicles are biocompatible in nature. Furthermore, the multiparticle tracking, Transwell® system, and cell imaging experimental results demonstrate that both the modification of pCB and the application of a magnetic field effectively accelerated the diffusion of the nanovehicles in the mucus and improved the endocytosis through Calu-3. The favorable cell uptake performance of Janus-MMSN-pCB in mucus systems with/without magnetic driving proves its potential role in the diagnosis, treatment, and imaging of mucosal-related diseases.
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Beagan, Abeer M., Ahlam A. Alghamdi, Shatha S. Lahmadi, Majed A. Halwani, Mohammed S. Almeataq, Abdulaziz N. Alhazaa, Khalid M. Alotaibi, and Abdullah M. Alswieleh. "Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System." Polymers 13, no. 1 (December 25, 2020): 59. http://dx.doi.org/10.3390/polym13010059.

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Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.
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34

Baillié, K., J. Marques, and L. Piau. "Building protoplanetary disks from the molecular cloud: redefining the disk timeline." Astronomy & Astrophysics 624 (April 2019): A93. http://dx.doi.org/10.1051/0004-6361/201730677.

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Context. Planetary formation models are necessary to understand the characteristics of the planets that are the most likely to survive. Their dynamics, their composition and even the probability of their survival depend on the environment in which they form. We therefore investigate the most favorable locations for planetary embryos to accumulate in the protoplanetary disk: the planet traps. Aims. We study the formation of the protoplanetary disk by the collapse of a primordial molecular cloud, and how its evolution leads to the selection of specific types of planets. Methods. We use a hydrodynamical code that accounts for the dynamics, thermodynamics, geometry and composition of the disk to numerically model its evolution as it is fed by the infalling cloud material. As the mass accretion rate of the disk onto the star determines its growth, we can calculate the stellar characteristics by interpolating its radius, luminosity and temperature over the stellar mass from pre-calculated stellar evolution models. The density and midplane temperature of the disk then allow us to model the interactions between the disk and potential planets and determine their migration. Results. At the end of the collapse phase, when the disk reaches its maximum mass, it pursues its viscous spreading, similarly to the evolution from a minimum mass solar nebula (MMSN). In addition, we establish a timeline equivalence between the MMSN and a “collapse-formed disk” that would be older by about 2 Myr. Conclusions. We can save various types of planets from a fatal type-I inward migration: in particular, planetary embryos can avoid falling on the star by becoming trapped at the heat transition barriers and at most sublimation lines (except the silicates one). One of the novelties concerns the possible trapping of putative giant planets around a few astronomical units from the star around the end of the infall. Moreover, trapped planets may still follow the traps outward during the collapse phase and inward after it. Finally, this protoplanetary disk formation model shows the early possibilities of trapping planetary embryos at disk stages that are anterior by a few million years to the initial state of the MMSN approximation.
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Utami, Inggita, Radhitiya Anjar Pramana Putra, Muhammad Saputra Wibowo, Febriant Isabella Yusuf, Fahmiatul Husna, Arviteno Eko, and Dennis Susanto. "TREE STRATIFICATION BASED ON ERUPTION DAMAGE LEVEL IN MOUNT MERAPI NATIONAL PARK YOGYAKARTA INDONESIA." Media Konservasi 26, no. 1 (April 30, 2021): 71–81. http://dx.doi.org/10.29244/medkon.26.1.71-81.

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Mount Merapi’s eruption has caused damage to the forests in the Mount Merapi National Park (MMNP). Nine years after the eruption, the vertical structure of vegetation can illustrate the progress of succession. This study aimed to analyze the tree composition and stratification in different forest damage levels after the 2010 Merapi eruption. The study was conducted in March 2019 at three stations, namely station A (heavy damage area), station B (moderate damage area), and station C (minor damage area). Vegetation parameters in each station were taken in a 10x100 plot and were processed using a tree profile diagram. Abiotic parameters were measured in each plot and analyzed using the correlation test. The results showed that the three stations were still dominated by the tree in Stratum C, but the tree density and tree height varied in proportion to the damage level. Station A in the heavy damage area has the lowest tree density (23 trees/0.1 ha) with a maximum tree height of 12 meters, in contrast to Station C in the minor damage area with tree density reaching 195 trees/0.1 ha and maximum tree height reaching 30 meters. Nine years after the Mount Merapi big eruption, the MMNP forests in Yogyakarta Province are still classified as young secondary forests. Key words: diagram, profile, succession, structure, vertical
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Ma, Jingwen, Shuxia Han, Yan Nian, Hongmei Li, and Zhijuan Yang. "Magnetic Mesoporous Silica Nanoparticles Incorporated with miR-451 Suppress Development of Cervical Cancer and Enhance Radio Sensitization in Cervical Cancer." Science of Advanced Materials 13, no. 9 (September 1, 2021): 1629–36. http://dx.doi.org/10.1166/sam.2021.4059.

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Cervical cancer (CC) is one of the most common gynecological malignancies with high mortality, threatening female’s health and reducing their life quality. This study evaluated the synergistic effect of magnetic mesoporous silica nanoparticles (MMSNs), miR-451 on radio sensitivity and cell apoptosis in CC. Magnetic mesoporous silica (Fe3O4/SiO2) nanoparticles were prepared and loaded with miR-451. Then the CC cells were treated with Fe3O4/SiO2 nanoparticles, miR-451-loaded Fe3O4/SiO2 nanoparticles (control group) and untreated (blank group). Cell proliferation was determined by MTT assay, while apoptosis and Hoechst were assessed by flow cytometry. As colony formation assay was conducted to evaluate cell sensitivity to radiotherapy, Western blot analysis detected the expression of apoptosis- and radiosensitization-related genes. Iron oxide particles were present inside and outside the SiO2 channel with characteristic peaks for Fe and skeleton of silica. The miR-451-loaded Fe3O4/SiO2 nanoparticles had an obvious absorption peak with drug loading rate and encapsulation rate reaching 6% and 91%. The release content of drugs increased with decreased pH. Of note, combined treatment with miR-451 and Fe3O4/SiO2 nanoparticles significantly decreased cancer cell proliferation and increased apoptosis (34.36±2.31%), compared to control group and blank group. Furthermore, the levels of D0 (1.67), Dq (0.94), N (1.56), and SF2 (0.43) declined in the presence of miR-451-Fe3O4/SiO2 nanoparticles, accompanied with elevation of ATM and γ-H2AX expression. Meanwhile, the treated CC cells had decreased expressions of DNA damage repair related genes ATM and γ-H2AX. MMSNs carrying miR-451 decreased cell proliferation activity and increased apoptosis and sensitized the CC cells to radiotherapy, to improve tissue repairing. These findings may provide a novel insight into pathogenesis of CC.
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Panjaitan, Roymon, Muhammad Hasan, and Resista Vilkana. "Sophisticated technology innovation capability: Entrepreneurial resilience on disaster -resilient MSMEs." Serbian Journal of Management 17, no. 2 (2022): 375–88. http://dx.doi.org/10.5937/sjm17-39294.

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The level of productivity should be increased and maintained to sustain the success of micro, small and medium enterprises (MSMEs). Furthermore, entrepreneurial resilience requires advanced technological innovation capabilities to avoid continual external disasters. Therefore, this research explores the connection between entrepreneurial resilience, disaster-resilient MSMEs, and new ideas on complex technical innovations to modulate entrepreneurship. Partial Least Squares are used to process 177 MSMEs respondents in Central Java, Indonesia and the findings successfully bridged the gap between entrepreneurial resilience and disaster-resistant MSMEs. The is mediated by sophisticated technology innovation capability. Furthermore, corporate owners and managers are concerned with the ongoing adaptation and creation of complicated technologies concerning sophisticated innovation capabilities. These findings indicate that entrepreneurial resilience contributes to sophisticated technological innovation capability. The findings also show that entrepreneurial resilience contributes to disaster-resilient MSMEs and demonstrate the importance of understanding how entrepreneurs survive during conditions of uncertainty. This theoretical conclusion gives rise to a new competitive resource advantage theory perspective in which sophisticated technology's inventive capacities might be strengthened when entrepreneurial resilience is stronger. The entrepreneurial resilience can improve when corporate organizations or MSMEs players have advanced technical resource capabilities.
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Zhou, Ping, Samar Safi-Harb, Yang Chen, and Xiao Zhang. "An XMM-Newton study of the mixed-morphology supernova remnant W28." Proceedings of the International Astronomical Union 9, S296 (January 2013): 360–61. http://dx.doi.org/10.1017/s1743921313009824.

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AbstractWe perform an XMM-Newton study of the mixed-morphology supernova remnant (MMSNR) W28. The X-ray spectrum arising from the northeastern shell consists of a thermal component plus a non-thermal power-law component with a hard photon index (~1.5). Non-thermal bremsstrahlung is the most favourible origin of the hard X-ray emission. The gas in the SNR interior is centrally peaked and best described by a two-temperature thermal model. We found a non-uniform absorption column density and temperature profile for the central gas, indicating that the remnant is evolving in a non-uniform environment with denser material in the east. We argue that the cloudlet evaporation is an indispensable process to explain both the spectral properties and the clumpiness in the X-ray emission.
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Chen, Xiaodi, Li Xu, Lan Jin, Bin Sun, Guofeng Gu, Lili Lu, and Min Xiao. "Efficient and Regioselective Synthesis of β-GalNAc/GlcNAc-Lactose by a Bifunctional Transglycosylating β-N-Acetylhexosaminidase from Bifidobacterium bifidum." Applied and Environmental Microbiology 82, no. 18 (July 15, 2016): 5642–52. http://dx.doi.org/10.1128/aem.01325-16.

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ABSTRACTβ-N-Acetylhexosaminidases have attracted interest particularly for oligosaccharide synthesis, but their use remains limited by the rarity of enzyme sources , low efficiency, and relaxed regioselectivity of transglycosylation. In this work, genes of 13 β-N-acetylhexosaminidases, including 5 fromBacteroides fragilisATCC 25285, 5 fromClostridium perfringensATCC 13124, and 3 fromBifidobacterium bifidumJCM 1254, were cloned and heterogeneously expressed inEscherichia coli. The resulting recombinant enzymes were purified and screened for transglycosylation activity. A β-N-acetylhexosaminidase named BbhI, which belongs to glycoside hydrolase family 20 and was obtained fromB. bifidumJCM 1254, possesses the bifunctional property of efficiently transferring both GalNAc and GlcNAc residues through β1-3 linkage to the Gal residue of lactose. The effects of initial substrate concentration, pH, temperature, and reaction time on transglycosylation activities of BbhI were studied in detail. With the use of 10 mMpNP-β-GalNAc or 20 mMpNP-β-GlcNAc as the donor and 400 mM lactose as the acceptor in phosphate buffer (pH 5.8), BbhI synthesized GalNAcβ1-3Galβ1-4Glc and GlcNAcβ1-3Galβ1-4Glc at maximal yields of 55.4% at 45°C and 4 h and 44.9% at 55°C and 1.5 h, respectively. The model docking of BbhI with lactose showed the possible molecular basis of strict regioselectivity of β1-3 linkage in β-N-acetylhexosaminyl lactose synthesis.IMPORTANCEOligosaccharides play a crucial role in many biological events and therefore are promising potential therapeutic agents. However, their use is limited because large-scale production of oligosaccharides is difficult. The chemical synthesis requires multiple protecting group manipulations to control the regio- and stereoselectivity of glycosidic bonds. In comparison, enzymatic synthesis can produce oligosaccharides in one step by using glycosyltransferases and glycosidases. Given the lower price of their glycosyl donor and their broader acceptor specificity, glycosidases are more advantageous than glycosyltransferases for large-scale synthesis. β-N-Acetylhexosaminidases have attracted interest particularly for β-N-acetylhexosaminyl oligosaccharide synthesis, but their application is affected by having few enzyme sources, low efficiency, and relaxed regioselectivity of transglycosylation. In this work, we describe a microbial β-N-acetylhexosaminidase that exhibited strong transglycosylation activity and strict regioselectivity for β-N-acetylhexosaminyl lactose synthesis and thus provides a powerful synthetic tool to obtain biologically important GalNAcβ1-3Lac and GlcNAcβ1-3Lac.
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Raman, Prashant, Kirk Fuller, and Don A. Gregory. "Spectropolarimetric Properties of a Gallium Nanoparticle Layer on a Sapphire Substrate." Journal of Nanoparticles 2014 (November 2, 2014): 1–8. http://dx.doi.org/10.1155/2014/408350.

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Gallium nanoparticles (Ga NPs) are currently the subject of vigorous research as possible substrates in surface-enhanced Raman scattering (SERS) experiments in the ultraviolet spectral domain. Verification of any comprehensive model of the interaction of electromagnetic radiation with Ga NPs requires that complete polarimetric measurements be made. These spectropolarimetric properties can be obtained using a Mueller matrix spectropolarimeter (MMSP). The position of localized surface plasmon resonances (LSPRs) and spectral depolarization data of Ga NPs in the 300 to 1100 nm spectral region are presented. Spectral depolarization data may be of value in creating a better understanding of how light couples to individual nanoparticles, as well as the role played by interparticle coupling and the connection to phenomena such as SERS.
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Marhaento, Hero, and Lies Rahayu Wijayanti Faida. "Risiko Kepunahan Keanekaragaman Hayati di Taman Nasional Gunung Merapi: Tinjauan Spasial." Jurnal Ilmu Kehutanan 9, no. 2 (March 23, 2016): 75. http://dx.doi.org/10.22146/jik.10189.

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Gunung Merapi merupakan habitat dari berbagai spesies khas pegunungan Jawa bagian tengah. Namun demikian, tingginya aktivitas vulkanik Gunung Merapi dan besarnya tekanan masyarakat terhadap kawasan menyebabkan keanekaragaman hayati di sekitar kawasan Gunung Merapi berisiko untuk punah. Penelitian ini bertujuan untuk melakukan analisis spasial risiko kepunahan keanekaragaman hayati di Taman Nasional Gunung Merapi (TNGM). Analisis risiko dilakukan dengan mengukur komponen risiko, yaitu: kerawanan, elemen yang berisiko, dan kerentanan. Identifikasi komponen risiko dilakukan dengan melaksanakan grup diskusi terarah dengan staf Taman Nasional Gunung Merapi. Analisis risiko diukur menggunakan analisis spasial dengan perangkat lunak ArcGIS 10.1. Hasil penelitian menunjukkan bahwa kawasan Taman Nasional Gunung Merapi memiliki kawasan dengan tingkat risiko tinggi seluas 2185.6 ha (35,6%), risiko sedang seluas 3910,1 ha (63,6%), dan risiko rendah seluas 49,8 ha (0,8%). Wilayah yang berisiko tinggi berada di wilayah Resort Pengelolaan Taman Nasional (RPTN) Dukun Kabupaten Magelang, RPTN Turi-Pakem Kabupaten Sleman, dan RPTN Kemalang Kabupaten Klaten.Kata kunci: analisis risiko, keanekaragaman hayati, Taman Nasional Gunung Merapi, analisis spasial, vulkanik. Risk of biodiversity extinction in Gunung Merapi National Park : Spatial assessionAbstractThe Mount Merapi (MM) has a unique landscape and becomes the habitat for mountainous species in the central Java, Indonesia. However, high volcanic activities and massive public pressure on its natural resources have increased the risk of biodiversity extinction in the MM. This study aims to assess the spatial risk of biodiversity extinction in the Mount Merapi National Park (MMNP). The risk analysis has been done by spatially measuring the risk elements i.e. hazard area, element at risk, and vulnerability rate. A Focus Group Discussion has been done to define and to identify components of each risk element. A spatial analysis using ArcGIS 10.1 has been used to measure the risk. The results showed that MMNP have three levels of risks: high risk level area (2185.6 ha, 35. 6%), moderate risk area (3910.1 ha, 63.6%) and low risk area (49.8 ha, 0.8%). The high risk areas were located in Resort Pengelolaan Taman Nasional (RPTN) Dukun in Magelang Distict, RPTN Turi-Pakem in Sleman District, and RPTN Kemalang in Klaten District.
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Zhou, Yun, Mian Yu, Changjun Tie, Yang Deng, Junqing Wang, Yunfei Yi, Fan Zhang, et al. "Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer." Research 2021 (June 18, 2021): 1–15. http://dx.doi.org/10.34133/2021/9760398.

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Benefiting from treating diseases at the genetic level, gene therapy has been considered a new revolution in the biomedical field. However, the extracellular and intracellular barriers during gene transport such as enzymatic degradation and endo-/lysosomal sequestration significantly compromise the therapeutic efficacy. Though photochemical internalization (PCI) has emerged as a promising approach for causing endo-/lysosomal leakage with translocation of the internalized molecules into the cytosol, its effect is still unsatisfactory due to the insufficient light penetration depth. Here, we develop tumor microenvironment-specific enhanced gene delivery by means of ROS generated from the in situ cascaded catalytic reactions in tumors involving GOx-mediated redox reaction and Mn2+-mediated Fenton-like reaction. The efficient enzymatic protection and successful endo-/lysosomal escape of cargo gene complexes have been demonstrated. Moreover, anti-Twist siRNA-loaded G@MMSNs-P exhibit tumor-specific biodegradation, excellent T1-weighted MR imaging, and significant inhibitory effects against breast cancer growth and pulmonary metastasis.
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Li, Kim KC, and Kevin AW Lee. "MMSP tumor cells expressing the EWS/ATF1 oncogene do not support cAMP-inducible transcription." Oncogene 16, no. 10 (March 1998): 1325–31. http://dx.doi.org/10.1038/sj.onc.1201649.

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Bautista, Joaquín, Alberto Cano, and Rocío Alfaro. "Models for MMSP-W considering workstation dependencies: A case study of Nissan’s Barcelona plant." European Journal of Operational Research 223, no. 3 (December 2012): 669–79. http://dx.doi.org/10.1016/j.ejor.2012.07.006.

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Sinclair, Kirstine. "Er klinisk psykologi brugbart, sheikh?" Tidsskrift for Islamforskning 11, no. 1 (December 19, 2017): 83. http://dx.doi.org/10.7146/tifo.v11i1.102874.

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Dette bidrag præsenterer et delprojekt under projektparaplyen “Modern Muslim Subjectivities”, som undersøger, hvorledes islamiske universiteter i vesten faciliterer unge menneskers dannelse og uddannelse med henblik på et liv på arbejdsmarkedet og som sådan. Undersøgelsen tager afsæt i to institutioners tekstmateriale, feltobservation og -deltagelse samt interviews med såvel ansatte som studerende. De to institutioner er Zaytuna College i Berkeley, Californien, USA, og Cambridge Muslim College i Storbritannien.This contribution introduces a subproject under the larger Modern Muslim Subjectivities Project (MMSP), which investigates how Islamic universities in the West facilitate the education and formation of young individuals with reference to their professional and social adult lives. The investigation takes its point of departure in field observations, participation, interviews with faculty members and students as well as textual analyses at two institutions: Zaytuna College in Berkeley, California, US, and Cambridge Muslim College in the UK.
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Sala, Jolanta, and Halina Tańska. "Kreowanie i przygotowywanie systemów informatycznych w przedsiębiorstwach MMSP jako główne czynniki rozwoju polskiego społeczeństwa informacyjnego." Nierówności społeczne a wzrost gospodarczy 58, no. 2 (2019): 198–208. http://dx.doi.org/10.15584/nsawg.2019.2.15.

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Sweke, Emmanuel A., Julius M. Assam, Takashi Matsuishi, and Abdillahi I. Chande. "Fish Diversity and Abundance of Lake Tanganyika: Comparison between Protected Area (Mahale Mountains National Park) and Unprotected Areas." International Journal of Biodiversity 2013 (February 26, 2013): 1–10. http://dx.doi.org/10.1155/2013/269141.

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High biodiversity is the most remarkable characteristic of Lake Tanganyika including vertebrates, invertebrates, and plants. A few protected areas have been created along the lake to protect its biodiversity. However, limited studies have been carried out to ascertain their effectiveness. The current study aimed at assessing and comparing fish diversity and abundance of Lake Tanganyika in a protected area (Mahale Mountains National Park (MMNP)) and unprotected areas surrounding it. The data were collected in the near shore zone at 5 m and 10 m depths using stationary visual census (SVC) technique. The protected area recorded higher fish richness and abundance than unprotected areas (P<0.05). It was concluded that the protected area is effective in conserving the fish diversity and abundance of the lake. However, more studies should be carried out regularly to explore the efficacy of the protected area in conservation of aquatic biodiversity and abundance.
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Dobrosavljević, Andrea, and Snežana Urošević. "The impact of human resource management on business process improvement: An analysis within the MSMEs of the textile and clothing industry." Bizinfo Blace 11, no. 2 (2020): 19–32. http://dx.doi.org/10.5937/bizinfo2002019d.

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Business process improvement is necessary given the need to satisfy consumers by delivering value-added products and services. The textile and clothing industry in the age of consumerism of textile and clothing products is facing the challenge of the constant need to meet and exceed consumer expectations. Establishing the practice of continuous business process improvement, especially within the micro, small and medium enterprises (MSMEs) of the textile and clothing industry, as the largest group of companies, is of particular importance in resisting these challenges. As the textile and clothing industry is labor-intensive and a large number of processes operate on the basis of direct engagement of human resources, there is a need to examine the impact of human resource management on the establishment of the practice of business process improvement in MSMEs. Within this paper, the impact of human resource management on the improvement of business processes was examined by applying regression analysis.
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Yin, Yi, and Thomas D. Petes. "Recombination between Homologous Chromosomes Induced by Unrepaired UV-Generated DNA Damage Requires Mus81p and Is Suppressed by Mms2p." PLOS Genetics 11, no. 3 (March 4, 2015): e1005026. http://dx.doi.org/10.1371/journal.pgen.1005026.

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Szucsova, Jaroslava, Adriana Zelenakova, Lubos Nagy, Michael Barutiak, Eva Benova, Vladimir Zelenak, and Vlasta Zavisova. "Influence of Ligands on Physicochemical Characteristics of Magnetic Nanoparticles." Journal of Nano Research 78 (April 17, 2023): 91–96. http://dx.doi.org/10.4028/p-2x4090.

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Magnetic-bead separation or purification serves as a technique for effective isolation of biomolecules. In presented work we prepared and characterized core-shell magnetic nanoparticle samples consisted of Fe3O4 core coated with SiO2 shell. Samples were subsequently coated with ligands MPTMS (3-(mercaptopropyl)trimethoxysilane), CPTMS (3-(chloropropyl)trimethoxysilane) and MMSP (3-(trimethoxysilyl)propyl methacrylate) with aim to increase the number of active centers for specific binding with RNA. Such samples were further investigated for their magnetic properties, size, and morphology. Magnetic properties were studied in DC field up to 5 T in temperature range 5 – 300 K. Size and morphology were determined from SEM micrographs and elemental compositions of the samples were investigated using EDX analysis. Modification of nanoparticle surface with different ligands leads to modification of active centers on the SiO2 surface on which the DNA and RNA molecules can be bounded. It also causes the change in magnetic and structural properties of nanoparticles.
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