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Academic literature on the topic 'MMPI-2'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2024

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Journal articles on the topic "MMPI-2"

1

Balasa, Rodica, Ciurba Bianca, Voidezan Septimiu, Simu Iunius, Hutanu Adina, Andone Sebastian, Romaniuc Andreea, Motataianu Anca, and Maier Smaranda. "The Matrix Metalloproteinases Panel in Multiple Sclerosis Patients Treated with Natalizumab: A Possible Answer to Natalizumab Non- Responders." CNS & Neurological Disorders - Drug Targets 17, no. 6 (August 28, 2018): 464–72. http://dx.doi.org/10.2174/1871527317666180703102536.

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Background: In the lymphocyte migration across the blood-brain barrier (BBB) in multiple sclerosis (MS), matrix metalloproteinases (MMPs) play an important role in the degradation of the basal membrane. Natalizumab (NAT), a monoclonal antibody, binds to the alpha-4 (α4) integrin leading to BBB impermeability. Approximately 30% of NAT-treated patients show clinical or MRI signs of BBB disruption. Objective: To determine whether NAT significantly influences the MMPs serum levels and to what extent these could be used as biomarkers in relapsing-remitting MS (RRMS) patients. Materials and Methods: This prospective study over a period of 8 months of NAT treatment, included 30 RRMS patients (mean age 38 ± 6 years; mean MS duration 12 ± 5 years), of which ten were initially naive to NAT and 15 were healthy controls. We determined the serum levels of the MMPs Panel (MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP12, and MMP13) quantified by a multiplex method at the beginning and end of the study. Results: After 8 months of NAT treatment, a statistically significant decrease was found in MMP9, MMP2, MMP3, MMP8, and MMP10 levels. Relapses during the study were correlated with a variation of MMP12 and MMP13 serum levels. MMP9 had the most numerous correlations with the EDSS score, Rio score, and duration of NAT treatment. MMPs signature (the sum of all MMPs) and the MMP9/MMP2 ratio significantly decreased during the study. Conclusion: 1. The serum level of MMP9 significantly decreased by NAT treatment and correlates with MS activity; 2. After eight months of NAT treatment, the MMPs signature and the MMP9/MMP2 ratio decreased; 3. MMP9 might be used as a biomarker in MS patients treated with NAT.

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Bartnykaitė, Agnė, Aistė Savukaitytė, Justina Bekampytė, Rasa Ugenskienė, Danguolė Laukaitienė, Erika Korobeinikova, Jurgita Gudaitienė, and Elona Juozaitytė. "The Role of Matrix Metalloproteinase Single-Nucleotide Polymorphisms in the Clinicopathological Properties of Breast Cancer." Biomedicines 10, no. 8 (August 4, 2022): 1891. http://dx.doi.org/10.3390/biomedicines10081891.

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(1) Background. Breast cancer is the leading cancer type among women. Despite convenient diagnostics at early stages, there is a need for continuous monitoring to predict more aggressive or recurring breast cancer forms. The evidence suggests that the detection of genetic biomarkers could help in improving disease management and reduce mortality. Matrix metalloproteinases (MMPs) are a large family of enzymes that perform physiologically relevant functions and have the potential properties to be biomarkers for cancer assessment. We aimed to evaluate the contribution and association of single-nucleotide polymorphisms (SNPs) in MMP genes (MMP1, MMP2, MMP3, MMP7, MMP8, MMP9) with clinicopathological breast-cancer features. (2) Methods. In this study, 100 breast cancer patients were genotyped by polymerase chain reaction–restriction fragment length polymorphism methodology (PCR–RFLP). (3) Results. The presence of the MMP7 rs11568818 A allele was associated with lower chances for poorly differentiated breast cancer. The lower possibility for HER2-positive breast cancer was associated with the presence of the MMP9 rs3918242 C allele. (4) Conclusions. These results indicate that MMP7 rs11568818 and MMP9 rs3918242 are potential biomarkers for the anticipation of breast cancer aggressiveness.

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Ikonomidis, John S., Jennifer W. Hendrick, Andrea M. Parkhurst, Amanda R. Herron, Patricia G. Escobar, Kathryn B. Dowdy, Robert E. Stroud, Elizabeth Hapke, Michael R. Zile, and Francis G. Spinale. "Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibition." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 1 (January 2005): H149—H158. http://dx.doi.org/10.1152/ajpheart.00370.2004.

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Alterations in matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) have been implicated in adverse left ventricular (LV) remodeling after myocardial infarction (MI). However, the direct mechanistic role of TIMPs in the post-MI remodeling process has not been completely established. The goal of this project was to define the effects of altering endogenous MMP inhibitory control through combined genetic and pharmacological approaches on post-MI remodeling in mice. This study examined the effects of MMP inhibition (MMPi) with PD-166793 (30 mg·kg−1·day−1) on LV geometry and function (conductance volumetry) after MI in wild-type (WT) mice and mice deficient in the TIMP-1 gene [TIMP-1 knockout (TIMP1-KO)]. At 3 days after MI (coronary ligation), mice were randomized into four groups: WT-MI/MMPi ( n = 10), TIMP1-KO-MI/MMPi ( n = 10), WT-MI ( n = 22), and TIMP1-KO-MI ( n = 23). LV end-diastolic volume (EDV) and ejection fraction were determined 14 days after MI. Age-matched WT ( n = 20) and TIMP1-KO ( n = 28) mice served as reference controls. LVEDV was similar under control conditions in WT and TIMP1-KO mice (36 ± 2 and 40 ± 2 μl, respectively) but was greater in TIMP1-KO-MI than in WT-MI mice (48 ± 2 vs. 61 ± 5 μl, P < 0.05). LVEDV was reduced from MI-only values in WT-MI/MMPi and TIMP1-KO-MI/MMPi mice (42 ± 2 and 36 ± 2 μl, respectively, P < 0.05) but was reduced to the greatest degree in TIMP1-KO mice ( P < 0.05). LV ejection fraction was reduced in both groups after MI and increased in TIMP1-KO-MI/MMPi, but not in WT-MI/MMPi, mice. These unique results demonstrated that myocardial TIMP-1 plays a regulatory role in post-MI remodeling and that the accelerated myocardial remodeling induced by TIMP-1 gene deletion can be pharmacologically “rescued” by MMP inhibition. These results define the importance of local endogenous control of MMP activity with respect to regulating LV structure and function after MI.

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Gömöri, Kamilla, Tamara Szabados, Éva Kenyeres, Judit Pipis, Imre Földesi, Andrea Siska, György Dormán, Péter Ferdinandy, Anikó Görbe, and Péter Bencsik. "Cardioprotective Effect of Novel Matrix Metalloproteinase Inhibitors." International Journal of Molecular Sciences 21, no. 19 (September 23, 2020): 6990. http://dx.doi.org/10.3390/ijms21196990.

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Background: We recently developed novel matrix metalloproteinase-2 (MMP-2) inhibitor small molecules for cardioprotection against ischemia/reperfusion injury and validated their efficacy in ischemia/reperfusion injury in cardiac myocytes. The aim of the present study was to test our lead compounds for cardioprotection in vivo in a rat model of acute myocardial infarction (AMI) in the presence or absence of hypercholesterolemia, one of the major comorbidities affecting cardioprotection. Methods: Normocholesterolemic adult male Wistar rats were subjected to 30 min of coronary occlusion followed by 120 min of reperfusion to induce AMI. MMP inhibitors (MMPI)-1154 and -1260 at 0.3, 1, and 3 µmol/kg, MMPI-1248 at 1, 3, and 10 µmol/kg were administered at the 25th min of ischemia intravenously. In separate groups, hypercholesterolemia was induced by a 12-week diet (2% cholesterol, 0.25% cholic acid), then the rats were subjected to the same AMI protocol and single doses of the MMPIs that showed the most efficacy in normocholesterolemic animals were tested in the hypercholesterolemic animals. Infarct size/area at risk was assessed at the end of reperfusion in all groups by standard Evans blue and 2,3,5-triphenyltetrazolium chloride (TTC) staining, and myocardial microvascular obstruction (MVO) was determined by thioflavine-S staining. Results: MMPI-1154 at 1 µmol/kg, MMPI-1260 at 3 µmol/kg and ischemic preconditioning (IPC) as the positive control reduced infarct size significantly; however, this effect was not seen in hypercholesterolemic animals. MVO in hypercholesterolemic animals decreased by IPC only. Conclusions: This is the first demonstration that MMPI-1154 and MMPI-1260 showed a dose-dependent infarct size reduction in an in vivo rat AMI model; however, single doses that showed the most efficacy in normocholesterolemic animals were abolished by hypercholesterolemia. The further development of these promising cardioprotective MMPIs should be continued with different dose ranges in the study of hypercholesterolemia and other comorbidities.

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Blau, Theodore H. "The MMPI, MMPI-2, and MMPI-A in Court (Book)." Journal of Personality Assessment 65, no. 1 (August 1995): 190–92. http://dx.doi.org/10.1207/s15327752jpa6501_16.

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Bachna, K. "MMPI/MMPI-2 Comparisons of Amnesic Patients." Archives of Clinical Neuropsychology 13, no. 6 (August 1998): 535–42. http://dx.doi.org/10.1016/s0887-6177(97)00043-7.

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Bachna, K., M. A. Sieggreen, L. Cermak, W. Penk, and M. O'Connor. "MMPI/MMPI-2:Comparisons of Amnesic Patients." Archives of Clinical Neuropsychology 13, no. 6 (August 1, 1998): 535–42. http://dx.doi.org/10.1093/arclin/13.6.535.

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Butler, Georgina S., Richard A. Dean, Eric M. Tam, and Christopher M. Overall. "Pharmacoproteomics of a Metalloproteinase Hydroxamate Inhibitor in Breast Cancer Cells: Dynamics of Membrane Type 1 Matrix Metalloproteinase-Mediated Membrane Protein Shedding." Molecular and Cellular Biology 28, no. 15 (May 27, 2008): 4896–914. http://dx.doi.org/10.1128/mcb.01775-07.

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ABSTRACT Broad-spectrum matrix metalloproteinase (MMP) inhibitors (MMPI) were unsuccessful in cancer clinical trials, partly due to side effects resulting from limited knowledge of the full repertoire of MMP substrates, termed the substrate degradome, and hence the in vivo functions of MMPs. To gain further insight into the degradome of MMP-14 (membrane type 1 MMP) an MMPI, prinomastat (drug code AG3340), was used to reduce proteolytic processing and ectodomain shedding in human MDA-MB-231 breast cancer cells transfected with MMP-14. We report a quantitative proteomic evaluation of the targets and effects of the inhibitor in this cell-based system. Proteins in cell-conditioned medium (the secretome) and membrane fractions with levels that were modulated by the MMPI were identified by isotope-coded affinity tag (ICAT) labeling and tandem mass spectrometry. Comparisons of the expression of MMP-14 with that of a vector control resulted in increased MMP-14/vector ICAT ratios for many proteins in conditioned medium, indicating MMP-14-mediated ectodomain shedding. Following MMPI treatment, the MMPI/vehicle ICAT ratio was reversed, suggesting that MMP-14-mediated shedding of these proteins was blocked by the inhibitor. The reduction in shedding or the release of substrates from pericellular sites in the presence of the MMPI was frequently accompanied by the accumulation of the protein in the plasma membrane, as indicated by high MMPI/vehicle ICAT ratios. Considered together, this is a strong predictor of biologically relevant substrates cleaved in the cellular context that led to the identification of many undescribed MMP-14 substrates, 20 of which we validated biochemically, including DJ-1, galectin-1, Hsp90α, pentraxin 3, progranulin, Cyr61, peptidyl-prolyl cis-trans isomerase A, and dickkopf-1. Other proteins with altered levels, such as Kunitz-type protease inhibitor 1 and beta-2-microglobulin, were not substrates in biochemical assays, suggesting an indirect affect of the MMPI, which might be important in drug development as biomarkers or, in preclinical phases, to predict systemic drug actions and adverse side effects. Hence, this approach describes the dynamic pattern of cell membrane ectodomain shedding and its perturbation upon metalloproteinase drug treatment.

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MINO, Yukiko, Takaki MAKINO, Shota KASAI, and Tooru OGUCHI. "MMPI-2 Restructured Clinical Scales and MMPI-2 Restructured Form." Proceedings of the Annual Convention of the Japanese Psychological Association 75 (September 15, 2011): 2PM005. http://dx.doi.org/10.4992/pacjpa.75.0_2pm005.

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Parisien, Michel. "DU MMPI AU MMPI-2-RF/MMPI-3 : L’ABANDON DES SUBTERFUGES." Revue québécoise de psychologie 43, no. 3 (2022): 217. http://dx.doi.org/10.7202/1094898ar.

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Dissertations / Theses on the topic "MMPI-2"

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Chojnacki, Joseph T. "The consistency of scores and configural patterns between the MMPI and MMPI-2 /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487777901659682.

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Ampudia, Rueda Amada, Crespo Guadalupe Sánchez, and Gómez Fernando Jiménez. "Diagnostic accuracy of the MMPI-2 with the Mexican criminal personality: The ROC curve analysis." Pontificia Universidad Católica del Perú, 2016. http://repositorio.pucp.edu.pe/index/handle/123456789/100481.

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The objective of this study is to assess the diagnostic accuracy of the personality of the Mexican criminal with the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). The inventory was administered to 1,740 Mexican participants of which 870 (728 male and 142 female) are prison inmates, processed and/or sentenced for various crimes from various prisons in Mexico City, and the other 870 participants (728 male and 142 female) are not prison inmates. The ROC (Receiver Operating Characteristic) curve analysis was used to assess the level of diagnostic accuracy through indexes of the Area below the curve (ABC), sensitivity (S) and specificity (E). The analysis was differentiated by gender and showed significant differences
El objetivo de este estudio es poder apreciar la precisión diagnóstica de la personalidad del delincuente mexicano con la prueba del Minnesota Multiphasic Personality Inventory-2 (MMPI-2). Se administró la prueba a un total de 1740 participantes mexicanos de los que 870 (728 varones y 142 mujeres) son reclusos, procesados y/o sentenciados por diferentes delitos, procedentes de diversas cárceles del Estado y Distrito Federal, y otros 870 (728 varones y 142 mujeres) son personas no reclusas. Se utilizó el análisis de la curva ROC (Receiver Operating Characteristic) para apreciar el nivel de precisión diagnóstica a través de sus índices del Área Bajo la Curva (ABC), su Sensibilidad (S) y Especificidad (E). El análisis, diferenciado por género, mostró notables diferencias.
O objetivo do presente estudo consiste em avaliar a precisão diagnóstica da personalidade do delinquente mexicano através da prova Minnesota Multiphasic Personality Inventory-2 (MMPI-2). A prova foi administrada a 1.740 participantes mexicanos, dos quais 870 (728 homens e 142 mulheres) são reclusos, julgados e condenados por diferentes delitos, procedentes de diferentes estabelecimentos prisionais da cidade do México, e outros 870 (728 homens e 142 mulheres) são pessoas não reclusas. Foi utilizada uma análise da curva de ROC (Receiver Operating Characteristics) para avaliar o nível de precisão diagnóstica através dos índices da Área Abaixo da Curva (ABC), sua sensibilidade (S) e Especificidade (E). A análise de diferenciação entre sexos revelou diferenças significativas.

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Richter, Wolfgang [Verfasser]. "Multimodales Assessment und Beschwerdenvalidierung mittels MMPI-2, MMPI-2-RF und BHI-2 : Analyse einer Stichprobe deutscher Patienten mit chronischen Schmerzen / Wolfgang Richter." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1125539186/34.

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Smith, Ashley M. "Assessing Personality Disorders Using the MMPI-2-RF." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1279132568.

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Sánchez, Crespo Guadalupe, Gómez Fernando Jiménez, and Rueda Amada Ampudia. "Detecting the simulation profile in MMPI-2: A proposal based on research." Pontificia Universidad Católica del Perú, 2012. http://repositorio.pucp.edu.pe/index/handle/123456789/101113.

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The aim of this study is to offer a profile detector of the falsifications that could be done to the MMPI-2. We propose minimal changes in the reversed order of the direct punctuations of L y K and the addition of four new specific scales: Odecp, Ds-r, S, F-K. Two groups were used: a control group, composed by normal and clinical subgroups who answered to the MMPI-2 according to standard procedure, and an experimental group, composed by three subgroups with different answer instructions: to give a good image, a bad image or an inconsistent answer. The result is a profile with the proposed scales of validity that initially allow the detection of different falsifications by the subjects when answering the MMPI-2 test.
Se propone un perfil detector de las falsificaciones que se dan con el MMPI-2, proponiendo la inversión de las puntuaciones directas de L y K y añadiendo cuatro nuevas escalas específicas: Odecp, Ds-r, S, F-K. Para esto se formaron dos grupos: control, compuesto por los subgrupos normal y clínico que contestan de forma estándar al MMPI-2, y experimental, formado por tres subgrupos instruidos para contestar al MMPI-2 de una manera determinada: mostrando buena imagen, mala imagen y de forma inconsistente. El resultado de este estudio es un perfil con las escalas de validez propuestas para la detección de las distintas falsificaciones que pueden realizar los sujetos que han contestado al cuestionario del MMPI-2.

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Maloney, Elizabeth R. "Faking good on the MMPI-2: A quantitative study." Scholarly Commons, 1998. https://scholarlycommons.pacific.edu/uop_etds/2593.

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The present study, conducted during the Fall 1996 and Spring 1997 academic terms, investigated the susceptibility of the Minnesota Multiphasic Personality Inventory 2$\sp{\rm nd}$ Edition (MMPI-2) to fake good behavior. The MMPI-2 was administered to a sample population of 114 teacher education students at a private California university. Administrations were in two sessions a minimum of four to six weeks apart, including one in which the subjects were instructed to respond honestly and another in which they were instructed to fake good. A questionnaire inquiring as to their veracity on each administration was also collected. The null hypotheses were that (1) there would be no statistically significant differences between standard and fake-good clinical scale scores in the subject population, (2) there would be no correlation between MMPI-2 validity indices and the degree of MMPI-2 clinical scale elevation from standard to fake-good conditions, (3) MMPI-2 scales would not be susceptible to fake-good behavior, and (4) there would be no correlation between a subject's perceived ability to fake good and their v actual fake-good performance. Each of the null hypotheses was rejected. Findings indicated that K (Consistency) corrected clinical scales on the MMPI-2, and to a lesser degree non-K corrected scales, were significantly susceptible to fake good behavior. The L (Lie) and K validity scales, however, were found to consistently detect the fake good behavior. Richwerger's (1989) results were generally confirmed, and recommendations for practical application of the instrument were addressed.

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Rapier, Jesica Leigh. "Construct Validity of the MMPI-2-RF Interpersonal Scales." Kent State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=kent1505393810241343.

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McBride, Daniel S. "Lie to Me: Malingered Depression on the MMPI-2." OpenSIUC, 2011. https://opensiuc.lib.siu.edu/theses/684.

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The Malingered Depression Scale (Md Scale; Steffan, Clopton, & Morgan, 2003) was recently developed for use with the MMPI-2 in attempts to distinguish individuals with genuine symptoms of depression from individuals who feign depression on the test. With respect to the Md scale, a relative lack of research and mixed findings regarding its utility are problematic; therefore, these issues were explored. The predictive and incremental validity of the Md scale were tested in this study to determine if use of the Md scale conferred a distinct predictive advantage over standard validity scales (e.g. F, FB, FP) in the differentiation between participants instructed to feign depression and participants who, prior to taking the MMPI-2, endorsed a significant number of depressive symptoms on a self-report measure. The Md scale demonstrated predictive and incremental validity in this study in distinguishing the two groups; however several limitations arose regarding use of the Md scale, most notably conceptual clarity within participant groups and problems regarding the use of cut scores.

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Priest, Wayne L. "Assessment of older adults using the MMPI-2 depression scale." Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/862264.

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The assessment of depression among older adults is difficult because depression rating scales can contain items that are related to cognitive deficits, physical illnesses, and other normal age changes. This study attempted to identify those items on the Minnesota Multiphasic Personality Inventory - Revised (MMPI-2) depression scale which strongly correlated with age as a basis for dividing the depression scale into two subscales: one measuring aging and the other measuring depression. These subscales were then evaluated by comparing two groups of older adults, one depressed and the other healthy, to determine if there would be no difference on the aging.subscale and a significant difference on the depression subscale.This research was conducted in two stages. The first stage entailed giving the extracted MMPI-2 depression scale (MMPI-2 D) to healthy older adults (n=114, aged 60 and above) and to healthy younger college students (n=142, aged 18 to 29) in order to assess which of the 57 MMPI-2 depression items were correlated with age.Using a cutoff score of 20% endorsement difference (Butcher & Pancheri, 1976) between the two groups (p<.001), it was determined that fifteen items of the MMPI-2 D scale differentiated the healthy older adult and the healthy younger adult groups and were therefore related to aging and not depression. Twelve of these items were in the depressive direction for older adults. Those items which strongly correlated with age were used to create an aging subscale of the MMPI-2 depression scale (MMPI-2 Da). The remaining items were assumed to measure depression and were considered a depression subscale (MMPI-2 Dd).The second stage of this research addressed the utility of the subscales. It was hypothesized that the MMPI-2 Da (aging subscale) would not discriminate between depressed and healthy older adults since both groups were the same with respect to age. It was further hypothesized that the MMPI-2 Dd (depression subscale) would discriminate between these groups because the groups were different with respect to depression.When the two subscales were used with a new healthy older adult group (n=54) and a depressed older adult group (n=36), both hypotheses were supported. There was no significant difference between the healthy and depressed older adults on the aging subscale (MMPI-2 Da) and there was a significant difference on the depression subscale (MMPI-2 Dd). Implications and limitations of these findings were discussed.
Department of Counseling Psychology and Guidance Services

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Patel, Kruti D. "MMPI-2-RF Empirical Correlates of Alliance and Treatment Engagment." Ohio University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1495801888301655.

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Books on the topic "MMPI-2"

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Hathaway, Starke R. MMPI-2. [Minneapolis, MN]: University of Minnesota Press, 1989.

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Greene, Roger L. The MMPI-2 / MMPI: An Interpretive Manual. Boston: Allyn and Bacon, 1991.

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L, Greene Roger, ed. The MMPI-2/MMPI: An interpretive manual. Boston: Allyn and Bacon, 1991.

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Butcher, James Neal. Essentials of MMPI-2 and MMPI-A interpretation. 2nd ed. Minneapolis: University of Minnesota Press, 2000.

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Butcher, James Neal. Essentials of MMPI-2 and MMPI-A interpretation. Minneapolis: University of Minnesota Press, 1992.

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Reilley, Robert R. MMPI-2 tutorial workbook. Austin, Tex: Pro-Ed, 1991.

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P, Anderson Wayne, ed. MMPI & MMPI-2: Interpretation manual for counselors and clinicians. 4th ed. Bristol, Pa: Accelerated Development, 1995.

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Butcher, James N., ed. MMPI-2: A practitioner's guide. Washington: American Psychological Association, 2006. http://dx.doi.org/10.1037/11287-000.

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1933-, Butcher James Neal, and American Psychological Association, eds. MMPI-2: A practitioner's guide. Washington, D.C: American Psycholgical Association, 2005.

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Butcher, James Neal. MMPI-2 in psychological treatment. New York: Oxford University Press, 1990.

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Book chapters on the topic "MMPI-2"

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Sellbom, Martin. "MMPI-2 and MMPI-2-RF Restructured Clinical Scales." In Encyclopedia of Personality and Individual Differences, 2927–30. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-24612-3_70.

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Sellbom, Martin. "MMPI-2 and MMPI-2-RF Restructured Clinical Scales." In Encyclopedia of Personality and Individual Differences, 1–4. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-28099-8_70-1.

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Sellbom, Martin, and Tayla T. C. Lee. "Assessment of Anxiety Symptoms Using the MMPI-2, MMPI-2-RF, and MMPI-A." In Handbook of Assessing Variants and Complications in Anxiety Disorders, 139–62. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-6452-5_10.

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Snellen, W. M. "Aanvullende schalen persoonlijkheidsvragenlijst MMPI-2." In Persoonlijkheidsdiagnostiek in de klinische praktijk, 117–35. Houten: Bohn Stafleu van Loghum, 2017. http://dx.doi.org/10.1007/978-90-368-1939-8_5.

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Butcher, James N., Giselle A. Hass, Roger L. Greene, and Linda D. Nelson. "The MMPI-2-Restructured form." In Using the MMPI-2 in forensic assessment., 249–63. Washington: American Psychological Association, 2015. http://dx.doi.org/10.1037/14571-015.

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Levitt, Eugene E., and Edward E. Gotts. "The MMPI-2 Content Scales." In The Clinical Application of MMPI Special Scales, 108–10. 2nd ed. New York: Routledge, 2021. http://dx.doi.org/10.4324/9781315827421-8.

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Tylicki, Jessica L., Anthony M. Tarescavage, and Dustin B. Wygant. "Assessment of Malingering Among Head Injury Litigants with the MMPI-2, MMPI-2-RF, and MMPI-3." In Detection of Malingering during Head Injury Litigation, 289–307. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-54656-4_8.

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Levitt, Eugene E., and Edward E. Gotts. "The Fate of Original MMPI Special Scales in MMPI-2." In The Clinical Application of MMPI Special Scales, 102–7. 2nd ed. New York: Routledge, 2021. http://dx.doi.org/10.4324/9781315827421-7.

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Koffmann, Andrew. "Minnesota Multiphasic Personality Inventory-2 (MMPI-2)." In Encyclopedia of Personality and Individual Differences, 2918–21. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-24612-3_917.

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Koffmann, Andrew. "Minnesota Multiphasic Personality Inventory-2 (MMPI-2)." In Encyclopedia of Personality and Individual Differences, 1–4. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-28099-8_917-1.

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Conference papers on the topic "MMPI-2"

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Sudjiwanati. "An Analysis of MMPI-2 on Ego Strength, Positive Malingering, and Anxiety." In Proceedings of the 5th ASEAN Conference on Psychology, Counselling, and Humanities (ACPCH 2019). Paris, France: Atlantis Press, 2020. http://dx.doi.org/10.2991/assehr.k.200120.035.

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Al Hashimi, Abdulaziz, Osama Al Kindi, Samya Al Farsi, Marwan Al Sawafi, Shaikha Al Mawali, Mohamed Al Abri, and Suleiman Al Hinai. "Automation and Digitalization of Polymerflood Viscosity Surveillance Through Machine Learning– A Case Study from Marmul." In ADIPEC. SPE, 2022. http://dx.doi.org/10.2118/211015-ms.

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Abstract Since its commencement in 2010, Marmul polymer EOR has been one of the worldwide successful full field applications. One of the key success factors for the project is maintainingwellhead viscosity at the target, which has been monitored by daily selective wellhead sampling. However, daily sampling covers only 7% of the polymer injectors. Recently, a digitalization project to enhance viscosity monitoring was successfully completed. One of the outcomes is utilizing the digital data available in field to have a live viscosity of all polymer injectors using an empirical power law model along with a calibration factor. Machine learning will handle any deviation of these readings by a well-established sampling program to continually re-calibrate the model.In this paper, the approach and outcomes of this projectare shared. Two polymer injectors are selected as a demonstration of the concept and main outcomes. Statistical evaluation was used to initially select the determining process parameters such as wellhead concentration, flowrate, tubing-head pressure, and tubing-head temperature. It has been concluded that wellhead polymer concentration is highly correlated to measured wellhead viscosity. The measured viscosities in the last two years (2020 and 2021) for each well were divided into; a training set (~65%) and a test set (~35%). The training set is used to calculate the calibration factor, while the test set is used to validate model predictions. Out of 415 date points, the average viscosity of polymer injectors MMPI-1 and MMPI-2 are 20.7 and 23.1 cP, respectively. The standard deviation of the measurements of injectors MMPI-1 and MMPI-2 are 3.3 and 4.8 cP, respectively. Viscosity was correlated to wellhead concentration by a power law model with experimentally obtained constant and law's exponent. Using the training set, a tuning parameter, α, was appliedwith criteria of minimummean absolute error (MAE) for each injector. α determined of MMPI-1 and MMPI-2 is 0.915 and 0.981, respectively. The model resulted in good predictions with an average MAE of around 20%. Furthermore, the model proved to be robust and reliable to be applied for live viscosity readings of all Marmul polymer injectors. Machine learning is essential for future tuning of the model for all polymer injectors in Marmul based established program of wellhead measurements. The outcomes of this digitalization and automation step in polymerflooding has demonstrated significant, positive impact on optimization of chemicals, resources, and the overall reservoir management. This work is setting another milestone in the utilization of data analytics and digitalization of fullfield polymer EOR. Machine learning coupled with excellent metering and data streaming have shown added value to overall project management. This is more critical with the shift towards agile work environment and net zero. Significant opportunities have been already realized as an outcome of this project such as quantification of polymer overdosage, which triggered a work in progress to reduce any value-eroding polymer dosage. In Marmul, the improved surveillance of wellhead viscosity and timely optimization of polymer dosage have already positively impacted project economics, GHG and HSE.

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Syuhada, Irwan, Artha Budi Susila Duarsa, and Ayu Anulus. "Relationship Between Self-confidence and Motivation: The Use of MMPI-2 in Medical Student." In International Conference on Medical Education (ICME 2021). Paris, France: Atlantis Press, 2021. http://dx.doi.org/10.2991/assehr.k.210930.019.

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""ASSESSMENT OF PERSONALITY AND PSYCHOPATHOLOGY IN THE CLINICAL-FORENSIC CONTEXT: CONTRIBUTION OF THE MMPI-2-RF"." In International Psychological Applications Conference and Trends. inScience Press, 2023. http://dx.doi.org/10.36315/2023inpact003.

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Moon, Ho Sik, and Sung-Jun Kim. "EP142 Diagnosis of pain deception using MMPI-2 based on XGBoost machine learning algorithm: a single-blinded randomized controlled trial." In ESRA Abstracts, 40th Annual ESRA Congress, 6–9 September 2023. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/rapm-2023-esra.207.

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Hurley, Jennifer R., Abdul Q. Sheikh, Meredith Beckenhaupt, Cameron Ingram, Andrew Mutchler, and Daria A. Narmoneva. "Self-Assembling Peptide Nanofibers for MMP Delivery and Cardiac Regeneration in Diabetes." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53761.

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Diabetes is a serious problem in the United States, afflicting 7.8% of the population with annual medical costs estimated at $116B in 2007 (1). Diabetic cardiomyopathy (DCM) is a cardiovascular complication of diabetes resulting in pathological alterations to the myocardium including circulatory defects, impaired heart muscle contraction, and progressive fibrosis. Cardiac fibrosis is associated with an imbalance between the deposition of the extracellular matrix (ECM) proteins by cardiac fibroblasts and the ECM proteolytic degradation via matrix metalloproteinases (MMPs). Recent studies have demonstrated that in the diabetic heart, expression and activity of MMP-2 are reduced, resulting in increased collagen accumulation and cardiac dysfunction (2). These observations suggest that a MMP-related mechanism may contribute to cardiac fibrosis, and that it may be attenuated through stimulation of native MMP-2 expression or delivery of exogenous MMP-2. Therefore, reduced MMP-2 activity in DCM may represent a novel target for therapeutic treatment (3). To achieve this, a special proteolytically-stable delivery scaffold would be needed, because native ECM is rapidly degraded by MMPs. The goal of this study is to determine if self-assembling peptide nanofibers can be used for long-term (several weeks) MMP delivery and enhancement of cardiac remodeling. This study tests the hypothesis that increased MMP-2 concentration (native or exogenous) in the nanofiber environment will promote matrix remodeling in diabetic cardiac fibroblasts in vitro.

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Litvinyuk, Aleksander A., Pavel V. Zhuravlev, Ekaterina V. Novikova, Ekaterina V. Kuzub, and Felix K. Akhmedov. "Creativity of young scientists and innovative development of the economy in modern Russia." In Sustainable and Innovative Development in the Global Digital Age. Dela Press Publishing House, 2022. http://dx.doi.org/10.56199/dpcsebm.txmx9493.

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The purpose of the article is to identify the main reasons that hinder the formation of human resources potential of Russian higher education institutions and scientific organizations on the basis of attracting talented and creative young professionals. The scientific novelty of the work lies in the systematic study of all motivational and personal factors that promote or hinder the involvement of people with creative thinking and positive attitude to innovative activities in academic activities. The research was conducted using the “Test-system for determining the structure of human motivational complex” and personal characteristics determination system on the MMPI-2 test. The respondents were young scientists, postgraduates and students of Russian universities. The analysis of the results made it possible to conclude that the current system of state regulation of the academic labor market is inefficient, which strategically reduces the probability of innovative economic development in modern Russia. The paper makes conceptual proposals that give an opportunity to raise the level of scientific and pedagogical activity at the present stage of Russia’s development. They mainly concern qualitative changes in the system of state financing of academic organizations, increasing social prestige of building a career path in the academic sphere of activity, reducing the level of bureaucratization and regulation of labor behavior in higher education and science.

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Javid, Khalid, Hadil Abu Khalifeh, Hadi Belhaj, and Mohammed Haroun. "Improving MMP by Co-Injection of Miscible CO2 With Abu Dhabi Crude Oil." In ASME 2013 32nd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/omae2013-10258.

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Miscible CO2 injection is a method to increase oil production. Combinations of Carbon dioxide with other gases as miscible solvents are emphasized in this paper to improve CO2 miscible injection process. Emphasis is on identifying CO2 solvent mixtures with reduced MMP to achieve miscibility at reasonable injection pressures in Abu Dhabi fields. Two targeted crude oils (Oil 1 and Oil 2) from Abu Dhabi carbonate reservoirs are utilized. The minimum miscibility pressure (MMP) of targeted oils with mixtures of N2, CH4, C2H6, and HC rich gas of varying composition with CO2 injection gas are evaluated through simulation. Cell to Cell and Semi-analytical (key tie lines) methods are applied using CMG simulator. Results show that miscibility is predicted to occur with multiple contact miscibility (MCM): vaporization and/or condensation mechanisms. The increase of C2H6 concentration in the CO2 injected gas reduced MMPs for targeted Oil 1 by 100 psi/10 mol%. However, N2, CH4 and HC rich gas increments in CO2 injected gas increased the MMPs for targeted Oil 1. MMP was observed to be 2300 psi for pure ethane with Oil 1. In addition, MMPs for targeted oils with N2/ C2H6 and N2/ CH4 injected gas mixtures are assessed. This study can open possibilities for future enriching of CO2 and N2 miscible injection to improve miscibility and recovery of oil.

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"MODELO DE INTEGRACIÓN PARA LA INTERVENCIÓN PSICOLÓGICA DE LAS ADICCIONES BASADO EN LA EVIDENCIA." In 23° Congreso de la Sociedad Española de Patología Dual (SEPD) 2021. SEPD, 2021. http://dx.doi.org/10.17579/sepd2021p075s.

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La presente propuesta consiste en la construcción de un modelo de integración para la intervención psicológica de las adicciones y sus patologías asociadas a partir de la PBE y del perfil psicológico de los pacientes de la Clínica San Juan de Dios de la ciudad de Manizales. Para ello, se aplico a 80 pacientes con consumo de SPA el Inventario Multifásico de Personalidad de Minnesota (MMPI-2) y del Índice Goldberg. De igual modo, se aplicó la Escala de Evaluación del Cambio de la Universidad de Rhode Island (URICA, por sus siglas en inglés) para evaluar los estadios de predisposición para el cambio y el proceso personal mediante el establecimiento de intervenciones efectivas y personalizadas. También se aplicó el Índice de Severidad de la Adicción (ISA), basándose en el auto-reporte de los consultantes sobre problemas recientes y a lo largo de su vida en las áreas médica, legal, de empleo/sustento, de consumo de alcohol y drogas, de familia/relaciones sociales y psiquiátrica/psicológica. En cada una de estas áreas se incluyó la evaluación de severidad por parte del entrevistador, indicando la necesidad de tratamiento para el consultante. Finalmente, se identificaron las sustancias que consumían los consultantes. Los datos brindaron los insumos para la elaboración de un programa adecuado de tratamiento en los servicios de Hospitalización y Hospital Día del Centro de Atención en Adicciones (CAD) de la Clínica San Juan de Dios, al que se denominó Modelo de Integración para la Intervención Psicológica de las Adicciones Basado en la Evidencia (MIIPABE) y que se presenta en este documento. Se reconoce el rol que desempeña el consumo de SPA en las distintas esferas de la vida y en la relación con el mundo y con los otros, por lo que va más allá del individuo y abarca también intervenciones grupales y familiares.

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Yang, Jing, Xing Lv, Yanqun Xiang, Xiang Guo, Jina Chen, and Xinyuan Guan. "Abstract 2254: CCL2/CCR2 axis signaling promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2 pathway via upregulating MMP2 and MMP9." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2254.

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Reports on the topic "MMPI-2"

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Hernandez-Barrantes, Sonia, and Rafael Fridman. Extracellular Matrix Regulations of Membrane Type 1-Matrix Metalloproteinasis (MT1-MMP) and Matrix Metalloproteinase-2 (MMP-2) in Human Breast Fibroblasts. Fort Belvoir, VA: Defense Technical Information Center, August 2000. http://dx.doi.org/10.21236/ada395355.

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Harnandez-Barrantes, Sonia, and Rafael Fridman. Extracellular Matrix Regulations of Membrane Type 1 - Matrix Metalloproteinasis (MT1-MMP) and Matrix Metalloproteinase-2 (MMP-2) in Human Breast Fibroblasts. Fort Belvoir, VA: Defense Technical Information Center, August 2001. http://dx.doi.org/10.21236/ada396694.

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Hernandez-Barrantes, Sonia, and Rafael Fridman. Extracellular Matrix Regulations of Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) and Matrix Metalloproteinase-2 (MMP-2) in Human Breast Fibroblasts. Fort Belvoir, VA: Defense Technical Information Center, August 2002. http://dx.doi.org/10.21236/ada413613.

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Huang, Kecheng. MMP-2 genetic variants influences platinum-induced myelosuppression of cervical cancer: A protocol for systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0178.

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Yahav, Shlomo, John Brake, and Noam Meiri. Development of Strategic Pre-Natal Cycling Thermal Treatments to Improve Livability and Productivity of Heavy Broilers. United States Department of Agriculture, December 2013. http://dx.doi.org/10.32747/2013.7593395.bard.

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The necessity to improve broiler thermotolerance and live performance led to the following hypothesis: Appropriate comprehensive incubation treatments that include significant temperature management changes will promote angiogenesis and will improve acquisition of thermotolerance and carcass quality of heavy broilers through epigenetic adaptation. It was based on the following questions: 1. Can TM during embryogenesis of broilers induce a longer-lasting thermoregulatory memory (up to marketing age of 10 wk) that will improve acquisition of thermotolerance as well as increased breast meat yield in heavy broilers? 2. The improved sensible heat loss (SHL) suggests an improved peripheral vasodilation process. Does elevated temperature during incubation affect vasculogenesis and angiogenesis processes in the chick embryo? Will such create subsequent advantages for heavy broilers coping with adverse hot conditions? 3. What are the changes that occur in the PO/AH that induce the changes in the threshold response for heat production/heat loss based on the concept of epigenetic temperature adaptation? The original objectives of this study were as follow: a. to assess the improvement of thermotolerance efficiency and carcass quality of heavy broilers (~4 kg); b. toimproveperipheral vascularization and angiogenesis that improve sensible heat loss (SHL); c. to study the changes in the PO/AH thermoregulatory response for heat production/losscaused by modulating incubation temperature. To reach the goals: a. the effect of TM on performance and thermotolerance of broilers reared to 10 wk of age was studied. b. the effect of preincubation heating with an elevated temperature during the 1ˢᵗ 3 to 5 d of incubation in the presence of modified fresh air flow coupled with changes in turning frequency was elucidated; c.the effect of elevated temperature on vasculogenesis and angiogenesis was determined using in ovo and whole embryo chick culture as well as HIF-1α VEGF-α2 VEGF-R, FGF-2, and Gelatinase A (MMP2) gene expression. The effects on peripheral blood system of post-hatch chicks was determined with an infrared thermal imaging technique; c. the expression of BDNF was determined during the development of the thermal control set-point in the preoptic anterior hypothalamus (PO/AH). Background to the topic: Rapid growth rate has presented broiler chickens with seriousdifficulties when called upon to efficiently thermoregulate in hot environmental conditions. Being homeotherms, birds are able to maintain their body temperature (Tb) within a narrow range. An increase in Tb above the regulated range, as a result of exposure to environmental conditions and/or excessive metabolic heat production that often characterize broiler chickens, may lead to a potentially lethal cascade of irreversible thermoregulatory events. Exposure to temperature fluctuations during the perinatal period has been shown to lead to epigenetic temperature adaptation. The mechanism for this adaptation was based on the assumption that environmental factors, especially ambient temperature, have a strong influence on the determination of the “set-point” for physiological control systems during “critical developmental phases.” Recently, Piestunet al. (2008) demonstrated for the first time that TM (an elevated incubation temperature of 39.5°C for 12 h/d from E7 to E16) during the development/maturation of the hypothalamic-hypophyseal-thyroid axis (thermoregulation) and the hypothalamic-hypophyseal-adrenal axis (stress) significantly improved the thermotolerance and performance of broilers at 35 d of age. These phenomena raised two questions that were addressed in this project: 1. was it possible to detect changes leading to the determination of the “set point”; 2. Did TM have a similar long lasting effect (up to 70 d of age)? 3. Did other TM combinations (pre-heating and heating during the 1ˢᵗ 3 to 5 d of incubation) coupled with changes in turning frequency have any performance effect? The improved thermotolerance resulted mainly from an efficient capacity to reduce heat production and the level of stress that coincided with an increase in SHL (Piestunet al., 2008; 2009). The increase in SHL (Piestunet al., 2009) suggested an additional positive effect of TM on vasculogenesis and angiogensis. 4. In order to sustain or even improve broiler performance, TM during the period of the chorioallantoic membrane development was thought to increase vasculogenesis and angiogenesis providing better vasodilatation and by that SHL post-hatch.

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