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Dissertations / Theses on the topic 'Mirka'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Möldner, Mirka [Verfasser]. "Accountability of International Organizations and Transnational Corporations : A Comparative Analysis / Mirka Möldner." Baden-Baden : Nomos Verlagsgesellschaft mbH & Co. KG, 2019. http://d-nb.info/1192101103/34.

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2

Sagemann, Mirka [Verfasser]. "Krankenfürsorge für das Gesinde : Eine Untersuchung zum Landrechtsentwurf Pufendorfs und zur Arbeiterschutzgesetzgebung bis 1900 / Mirka Sagemann." Baden-Baden : Nomos Verlagsgesellschaft mbH & Co. KG, 2012. http://d-nb.info/1110061099/34.

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3

Henninger, Mirka [Verfasser], and Thomas [Akademischer Betreuer] Gschwend. "Psychometric modeling as a tool to investigate heterogeneous response scale use / Mirka Henninger ; Betreuer: Thomas Gschwend." Mannheim : Universitätsbibliothek Mannheim, 2019. http://d-nb.info/1197536981/34.

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4

Mosch, Mirka [Verfasser]. "Diagnostikmethoden in der politischen Bildung : Vorstellungen von Schüler/-innen im Unterricht erheben und verstehen / Mirka Mosch." Gießen : Universitätsbibliothek, 2013. http://d-nb.info/1065319169/34.

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5

Lochmüller, Mirka [Verfasser]. "Simultaneous Optimization of Scheduling, Plant and Process Design of Sequential Multi-Purpose Batch Plants / Mirka Lochmüller." München : Verlag Dr. Hut, 2017. http://d-nb.info/1128467429/34.

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6

Kowal, Mirka Katharina [Verfasser], and Petra [Akademischer Betreuer] Arck. "The immunomodulatory role of heme oxygenase-1 during late pregnancy in mice / Mirka Katharina Kowal. Betreuer: Petra Arck." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2013. http://d-nb.info/1045730629/34.

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7

Allmeroth, Kira [Verfasser], Martin [Gutachter] Denzel, Mirka [Gutachter] Uhlirova, and Ulrich [Gutachter] Baumann. "Metabolic control of hair follicle stem cell fate decisions / Kira Allmeroth ; Gutachter: Martin Denzel, Mirka Uhlirova, Ulrich Baumann." Köln : Universitäts- und Stadtbibliothek Köln, 2021. http://d-nb.info/1240382847/34.

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8

Kauppila, Timo Eino Sakari [Verfasser], Nils-Göran [Gutachter] Larsson, and Mirka [Gutachter] Uhlirova. "Mitochondrial DNA Mutagenesis in Metazoa: From Phenotypes to Rescue / Timo Eino Sakari Kauppila ; Gutachter: Nils-Göran Larsson, Mirka Uhlirova." Köln : Universitäts- und Stadtbibliothek Köln, 2018. http://d-nb.info/116458751X/34.

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9

Schnödt, Maria Angelika [Verfasser], Dagmar [Gutachter] Mörsdorf, Mirka [Gutachter] Uhlirova, and Hildegard [Gutachter] Büning. "Improving safety and establishing episomal maintenance of Adeno-associated viral vectors / Maria Angelika Schnödt ; Gutachter: Dagmar Mörsdorf, Mirka Uhlirova, Hildegard Büning." Köln : Universitäts- und Stadtbibliothek Köln, 2016. http://d-nb.info/1122713827/34.

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10

Allerding, Mirka [Verfasser]. "Charakterisierung des Heme-Responsive Gene 1-Proteins (HRG-1) als Interaktionspartner des Lysosomal-Assoziierten Membranproteins Typ 2 (LAMP-2) / Mirka Allerding." Kiel : Universitätsbibliothek Kiel, 2017. http://d-nb.info/1138979651/34.

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11

Basten, Mirka [Verfasser]. "mRNA-basierte Quantifizierung von Biomarkern zur Diagnostik von zervikalen intraepithelialen Neoplasien und von Zervixkarzinomen : Validierung des QuantiGene® 2.0 Plex Assays / Mirka Basten." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1189138999/34.

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12

Subramanian, Senthil Kumar [Verfasser], Jonathan [Akademischer Betreuer] Howard, and Mirka [Akademischer Betreuer] Uhlirova. "Differential Influence of Clinical Mycobacterium avium Strains on Distinct Autonomous Defense Capacities of Human Neutrophils / Senthil Kumar Subramanian. Gutachter: Jonathan Howard ; Mirka Uhlirova." Köln : Universitäts- und Stadtbibliothek Köln, 2014. http://d-nb.info/1053762496/34.

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13

Chatterjee, Sampurna [Verfasser], Mirka [Akademischer Betreuer] Uhlirova, and Bent [Akademischer Betreuer] Brachvogel. "Targeting the tumor blood vessels: VEGFR2 as a Biomarker and Therapeutic Target in Non Small Cell Lung Cancer / Sampurna Chatterjee. Gutachter: Mirka Uhlirova ; Bent Brachvogel." Köln : Universitäts- und Stadtbibliothek Köln, 2014. http://d-nb.info/109576585X/34.

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14

Erler, Mirka [Verfasser], Christoph [Akademischer Betreuer] Dittrich, Christoph [Gutachter] Dittrich, and Heiko [Gutachter] Faust. "Food and the middle class : The site of food transition in rural and urban Bengaluru, India / Mirka Erler ; Gutachter: Christoph Dittrich, Heiko Faust ; Betreuer: Christoph Dittrich." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1211173704/34.

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15

Koester, Janis [Verfasser], Sara [Gutachter] Wickström, Baumann [Gutachter] Ulrich, and Mirka [Gutachter] Uhlirova. "Mechanisms of aging-mediated loss of stem cell potency through changes in niche architecture and chromatin accessibility / Janis Koester ; Gutachter: Sara Wickström, Baumann Ulrich, Mirka Uhlirova." Köln : Universitäts- und Stadtbibliothek Köln, 2020. http://d-nb.info/1231992743/34.

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16

Erler, Mirka [Verfasser], Christoph [Akademischer Betreuer] Dittrich, Christoph Gutachter] Dittrich, and Heiko [Gutachter] [Faust. "Food and the middle class : The site of food transition in rural and urban Bengaluru, India / Mirka Erler ; Gutachter: Christoph Dittrich, Heiko Faust ; Betreuer: Christoph Dittrich." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-13A8-8-1.

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17

Poznarová, Vendula. "4 + 4." Master's thesis, Akademie múzických umění v Praze.Hudební a taneční fakulta. Knihovna, 2015. http://www.nusl.cz/ntk/nusl-253754.

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In my master thesis I compare four different personalities of the recent Czech contemporary dance and their dissimilar attitude to creation. The contents of my research are influences on forming and progress of their work and different creative backgrounds that lead to the uniqueness of their choreographical way and method. Dissimilarity of this process I negotiate through the insight into the four conrete results of their work, so through the four current choreographical pieces of these artists.

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18

Weißenburg, Astrid [Verfasser], Birgit [Akademischer Betreuer] Neuer, Adelheid [Akademischer Betreuer] Hu, Mirka [Gutachter] Dickel, Sara [Gutachter] Fürstenau, Gabriele [Gutachter] Budach, and Sabine [Gutachter] Liebig. "Plurilingual Approaches to Spatial Education – Perspectives of Primary Schools in the German Context. / Astrid Weißenburg. Betreuer: Birgit Neuer ; Adelheid Hu. Gutachter: Mirka Dickel ; Sara Fürstenau ; Gabriele Budach ; Sabine Liebig." Karlsruhe : Pägogische Hochschule Karlsruhe, 2016. http://d-nb.info/1104003341/34.

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19

Cruz, Molina Sara de la [Verfasser], Bjorn [Gutachter] Schumacher, Mirka [Gutachter] Uhlirova, Siegfried [Gutachter] Roth, and Alvaro [Gutachter] Rada-Iglesias. "Poised enhancers are key cis-regulatory elements during ESC differentiation whose activity is facilitated by Polycomb repressive complex 2 / Sara de la Cruz Molina ; Gutachter: Bjorn Schumacher, Mirka Uhlirova, Siegfried Roth, Alvaro Rada-Iglesias." Köln : Universitäts- und Stadtbibliothek Köln, 2017. http://d-nb.info/114862371X/34.

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20

Jelinek, Mirka [Verfasser]. "Internationales Schuldrecht in der Tschechischen Republik und Europäischen Union : Eine Untersuchung des tschechischen internationalen Schuldrechts, unter besonderer Berücksichtigung des tschechischen Vertragskollisionsrechts im Vergleich mit dem Römischen EWG-Übereinkommen über das auf vertragliche Schuldverhältnisse anzuwendende Recht / Mirka Jelinek." Aachen : Shaker, 2003. http://d-nb.info/1170542638/34.

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21

Nalluri, Joseph Jayakar. "NETWORK ANALYTICS FOR THE MIRNA REGULOME AND MIRNA-DISEASE INTERACTIONS." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/5012.

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miRNAs are non-coding RNAs of approx. 22 nucleotides in length that inhibit gene expression at the post-transcriptional level. By virtue of this gene regulation mechanism, miRNAs play a critical role in several biological processes and patho-physiological conditions, including cancers. miRNA behavior is a result of a multi-level complex interaction network involving miRNA-mRNA, TF-miRNA-gene, and miRNA-chemical interactions; hence the precise patterns through which a miRNA regulates a certain disease(s) are still elusive. Herein, I have developed an integrative genomics methods/pipeline to (i) build a miRNA regulomics and data analytics repository, (ii) create/model these interactions into networks and use optimization techniques, motif based analyses, network inference strategies and influence diffusion concepts to predict miRNA regulations and its role in diseases, especially related to cancers. By these methods, we are able to determine the regulatory behavior of miRNAs and potential causal miRNAs in specific diseases and potential biomarkers/targets for drug and medicinal therapeutics.

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22

Li, Na [Verfasser]. "Global profiling of miRNA and the hairpin precursor : insights into miRNA processing and novel miRNA discovery / Na Li." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1026694744/34.

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23

Stähler, Cord Friedrich [Verfasser]. "Von Plattformen zu miRNA-Biomarkern : Methoden zur miRNA-Molekulardiagnostik / Cord Friedrich Stähler." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2018. http://d-nb.info/1233286161/34.

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24

Kadri, Sabah. "miRNA Regulation in Development." Research Showcase @ CMU, 2012. http://repository.cmu.edu/dissertations/186.

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microRNAs (miRNAs) are small (20-23 nt), non-coding single stranded RNA molecules that play an important role in post-transcriptional regulation of protein-coding genes. miRNAs have been found in all animal lineages, and have been implicated as critical regulators during development in multiple species. The echinoderms, Strongylocentrotus purpuratus (sea urchin) and Patiria miniata (sea star) are excellent model organisms for studying development due to their well-characterized transcriptional gene networks, ease of working with their embryos in the laboratory and phylogenetic position as invertebrate deuterostomes. Literature on miRNAs in echinoderm embryogenesis is limited. It has been shown that RNAi genes are developmentally expressed and regulated in sea urchin embryos, but no study in the sea urchin has examined the expression of miRNAs. The goal of my work has been to study miRNA regulation in echinoderm developmental gene networks. I have identified developmentally regulated miRNAs in sea urchin and sea star embryos, using a combination of computational and wet lab experimental techniques. I developed a probabilistic model (named HHMMiR) based on hierarchical hidden Markov models (HHMMs) to classify genomic hairpins into miRNA precursors and random stem-loop structures. I then extended this model to make an efficient decoder by introduction of explicit state duration densities. We used the Illumina Genome Analyzer to sequence small RNA libraries in mixed stage population of embryos from one to three days after fertilization of S. purpuratus and P. miniata. We developed a computational pipeline for analysis of these miRNAseq data to reveal the miRNA populations in both species, and study their differential expression. We also used northern blots and whole mount in situ hybridization experimental techniques to study the temporal and spatial expression patterns of some of these miRNAs in sea urchin embryos. By knocking down the major components of the miRNA biogenesis pathway, we studied the global effects of miRNAs on embryo morphology and differentiation genes. The biogenesis genes selected for this purpose are the RNAse III enzyme, Dicer and Argonaute. Dicer is necessary for the processing of mature miRNAs from hairpin structures while Ago is a necessary part of the RISC (RNA interference silencing complex) assembly, which is required for the miRNA to hybridize to its target mRNA site. Knocking down these genes hinders normal development of the sea urchin embryo and leads to loss of the larval skeleton, a novel phenotype not seen in sea stars, as well as abnormal gastrulation. Comparison of differentiation gene marker expression between control and Ago knocked down sea urchin embryos shows interesting patterns of expansion and suppression of adjoining some embryonic territories, while ingression of larval skeletogenesis progenitors does not occur.

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25

Bernardes, Mário Vinícius Angelete Alvarez. "Expressão de miRNA-92a, miRNA-133a e miRNA-145 e correlações clínico-patológica e prognóstica em pacientes com câncer esporádico de cólon." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-22082017-094556/.

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Introdução e Justificativa: O câncer colorretal é a 3ª neoplasia maligna mais incidente no mundo, e apresenta comportamento bastante heterogêneo aos tratamentos instituídos. Conseguir diferenciar os pacientes de acordo com seu prognóstico e comportamento tumoral é um desafio. A biologia molecular, através dos microRNA (miRNA), pode contribuir na identificação do perfil tumoral e ajudar a predizer os desfechos clínicos. Objetivos: Comparar a expressão tecidual de miRNA-92a, miRNA-133a e miRNA-145 de pacientes com câncer de cólon, correlacionando o perfil de expressão de miRNA com aspectos clínicopatológico e prognóstico. Casuística e Métodos: Quantificação de miRNA-92a, miRNA-133a e miRNA-145 pela técnica de reação em cadeia de polimerase em tempo real (RTPCR) em amostras de tecido tumoral em pacientes com câncer esporádico de cólon (grupo de estudo) operados entre janeiro de 2010 a dezembro de 2011 e em amostras de tecido colônico sadio de pacientes saudáveis (grupo controle) submetidos à colonoscopia de rotina para rastreio de câncer colorretal. Os resultados das dosagens de miRNA foram correlacionados ao valor do antígeno cárcinoembrionário (CEA), idade, estadiamento, invasão linfovascular, sobrevida livre de doença e sobrevida global. Resultados: A idade média dos pacientes foi de 66 anos e 60% eram do sexo masculino. No momento do diagnóstico inicial 22% apresentavam metástase à distância, e em 80% dos pacientes foi atingida ressecção R0. A sobrevida global foi de 46 meses e a sobrevida livre de doença foi de 32 meses. Apenas o miRNA-133a esteve hiopoexpresso no grupo de estudo (p=0,0007). Ao se correlacionar os perfis de expressão dos miRNA às variáveis clínico-patológica e prognóstica, a hiperexpressão do miRNA-92a esteve associada a maior sobrevida global (p= 0,044). Discussão: O tempo de espera entre o encaminhamento para hospitais terciários e o início do tratamento oncológico pode contribuir para o elevado índice de pacientes com doença metastática ao diagnóstico. Melhores desfechos têm sido associados a hospitais de maior volume, aparentemente devido à maior expertise de que esses hospitais possuem. O miRNA-133a, um supressor tumoral, tem sido hipoexpresso em amostras tumorais quando comparadas a tecidos sadios. Por sua vez, a hiperexpressão do promotor tumoral miRNA-92a que esteve associada a melhor prognóstico, pode ser explicada por uma desregulação dos genes alvo desse miRNA ou por diferenças geográficas na expressão dos miRNA. Conclusão: o miRNA-133a encontra-se hipoexpresso em amostras tumorais, enquanto que a hiperexpressão do miRNA-92a esteve associada a melhor sobrevida global.
Introduction: Colorectal cancer is the 3rd most common malignancy in the world, and their incidence has been increase in the last decades. Although patients diagnosed with early stage tumors have more than 65% of overall survival, behavior of colorectal tumors and their response to established treatments is quite heterogeneous. Gap: In this context, becomes interesting differentiate patients according to their prognosis and tumor behavior. Molecular biology through the miRNA quantification can improve the identification of tumor profile and predict clinical outcomes. Propose: Evaluate tumor profile tissue expression of miRNA- 92a, miRNA- 133a and miRNA-145 in patients with non-hereditary colon cancer, correlating with clinicopathological variables and oncological outcomes. Assessing the ability of the expression of these miRNA predict the prognosis. Methods: A dosage of miRNA-92a, miRNA-133a and miRNA-145 was performed in tumor tissue samples from patients with colon cancer (called study group) and non-tumoral colonic tissue samples from healthy patients (called the control group) by real-time polymerase chain reaction. The results of miRNA levels were correlated with clinicopathological data and oncological outcomes. Results: Mean age was 66 years and 60% was male. At initial diagnosis, 22% of lesions had distant metastasis. R0 resection was achieved in 80% of patients. Disease-free survival was 32 months, and overall survival was 46 months. The MiRNA-133a showed higher values in the control group when compared to the study group (p = 0.0007), and miRNA-92a was associated with higher overall survival (p = 0.044). Discussion: Better outcomes in highly specialized centers could be explained by advances in surgical technique and perioperative care. MiRNA-133a was underexpressed in colonic tumoral tissue, likely others tumors. MiRNA-92a overexpression was associated with improve overall survival. It could be explained through deregulation of target genes or geographic patterns of miRNA expression. Conclusion: MiRNA-133a was underexpressed in study group, and over expression of miRNA-92a was associated with better overall survival.

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26

Cornejo, Mirando Stefanie Karina, Llajaruna Brenda Elizabeth Santiago, Torres Jazmín Berrocal, and Valverde Lucía Carolina Quiñones. "En la mira." Universidad Peruana de Ciencias Aplicadas (UPC), 2015. http://hdl.handle.net/10757/581482.

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27

Gebhardt, Marie Luise. "Enrichment of miRNA targets in REST-regulated genes allows filtering of miRNA target predictions." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17407.

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Vorhersagen von miRNA-Bindestellen enthalten oft einen hohen Prozentsatz an falsch positiven Ergebnissen (24-70%). Gleichzeitig ist es schwierig die biologischen Interaktionen von miRNAs und ihren Zieltranskripten auf experimentellem Wege und Genom weit zu messen. Daher wurde in der vorliegenden Arbeit die Frage beantwortet, ob ChIP-Sequenzierungsdaten, von denen es immer mehr gibt, verwendet werden können, um Vorhersagen von miRNA-Bindestellen zu filtern. Dabei wurde von einem Netzwerk aus miRNAs und Transkriptionsfaktoren gebraucht gemacht, die Zieltranskripte gemeinsam regulieren. Zunächst wurden verschiedene Methoden getestet, mit denen „Peaks“ aus der ChIP-Sequenzierung Zielgenen zugeordnet werden können. Zielgenlisten des transkriptionalen Repressors RE1-silencing transcription factor (REST/NRSF) wurden mithilfe von ChIP-Sequenzierungsdaten erzeugt. Ein Algorithmus zur Suche nach überrepräsentierten miRNA-Zielgenen in REST-Genlisten basierend auf Vorhersagen von TargetScanHuman wurde entwickelt und angewandt. Die detektierten „enrichment“-miRNAs waren Teil eines vielfältig regulierten REST-miRNA-Netzwerks. Mögliche Funktionen von miRNAs wurden vorgeschlagen und ihre Rolle im gemeinsamen Netzwerk mit REST und im damit gebildeten Netzwerkmotiv (Inkoherente Schleife zur Vorwärtskopplung Typ 2) wurde analysiert. Es stellte sich heraus, dass ein Filtern der Vorhersagen tatsächlich möglich ist, da Gene, die sowohl von REST als auch von einer oder mehreren „enrichment“-miRNAs reguliert werden, einen höheren Anteil an wahren miRNA-Transkript-Interaktionen haben.
Predictions of miRNA binding sites suffer from high false positive rates (24-70%) and measuring biological interactions of miRNAs and target transcripts on a genome wide scale remains challenging. In the thesis at hand the question was answered if the ever growing body of ChIP-sequencing data can be applied to filter miRNA target predictions by making use of the underlying regulatory network of miRNAs and transcription factors. First different methods for association of ChIP-sequencing peaks to target genes were tested. Target gene lists of the transcriptional repressor RE1-silencing transcription factor (REST/NRSF) were generated by means of ChIP-sequencing data. An enrichment analysis tool based on predictions from TargetScanHuman was developed and applied to find ‘enrichment’-miRNAs with over-represented targets in the REST gene lists. The detected miRNAs were shown to be part of a highly regulated REST-miRNA network. Possible functions could be assigned to them and their role in the regulatory network and special network motifs (incoherent feedforward loop of type 2) was analyzed. It turned out that miRNA target predictions of genes shared by enrichment-miRNAs and REST had a higher proportion of true positive associations than the TargetScanHuman background, thus the procedure made a filtering possible.

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28

Kerndlová, Darja. "Identita a image značky Milka." Master's thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-262290.

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This thesis deals with identity and brand image Milka. The main objective is to find out the identity and image of the brand Milka and to find out if they correspond each other. The thesis is divided into three chapters. The objective of the first chapter is to explain the term brand, identity and image. The objective of the second chapter is to reveal the identity of the brand Milka. The aim of the last chapter is then expose her image and compare it with identity.

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29

Johanning, Andreas Verfasser], Mirko [Akademischer Betreuer] [Gutachter] Hornung, and Dieter [Gutachter] [Scholz. "Methodik zur Ökobilanzierung im Flugzeugvorentwurf / Andreas Johanning ; Gutachter: Mirko Hornung, Dieter Scholz ; Betreuer: Mirko Hornung." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1133261876/34.

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30

Böck, Philipp Marcus [Verfasser], Mirko [Akademischer Betreuer] Hornung, and Horst [Akademischer Betreuer] Baier. "Einfluss neuartiger Flugzeugkonzepte auf die Flughafenkapazität / Philipp Böck. Gutachter: Mirko Hornung ; Horst Baier. Betreuer: Mirko Hornung." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/1035274612/34.

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31

Mirza, Harun [Verfasser]. "Essays in Empirical Macroeconomics / Harun Mirza." Bonn : Universitäts- und Landesbibliothek Bonn, 2013. http://d-nb.info/1046622471/34.

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32

Theuer, Mirko [Verfasser]. "Kontinuierliches Wälzschleifen von Zerspanwerkzeugen / Mirko Theuer." Garbsen : TEWISS - Technik und Wissen GmbH, 2020. http://d-nb.info/1209237792/34.

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33

Auyeung, Vincent C. (Vincent Churk-man). "Sequence determinants of pri-miRNA processing." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/72617.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2012.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student submitted PDF version of thesis.
Includes bibliographical references.
MicroRNAs (miRNAs) are short RNAs that regulate many processes in physiology and pathology by guiding the repression of target messenger RNAs. For classification purposes, miRNAs are defined as ~22 nt RNAs that are produced by the cleavage of endogenously transcribed hairpins. From a cellular perspective, however, miRNAs are the functional products of a multistep maturation pathway, and are thus defined by the ability of their precursors to enter this pathway. The cellular distinction between miRNA precursors and other hairpins is made in the first step of maturation, when the primary miRNA transcript (pri-miRNA) is cleaved by the Microprocessor, a complex containing Drosha, an RNase III enzyme, and an RNA-binding partner DGCR8. However, it is unclear how the Microprocessor distinguishes between these hairpins and authentic pri-miRNAs. In fact, C. elegans pri-miRNAs are not processed in human cells, illustrating the complexity of pri-miRNA recognition and processing. To systematically explore sequence determinants of pri-miRNA recognition, hundreds of billions of variants of human pri-miRNAs were generated, and millions of variants that were functional Microprocessor substrates were selected in vitro and sequenced. Analysis of the successful sequences revealed multiple determinants of pri-miRNA binding and cleavage, including hairpin secondary structure and primary sequence preferences in the terminal loop and flanking the hairpin. One of these determinants, a CNNC motif downstream of the Drosha cleavage site, is enriched in pri-miRNAs throughout bilaterian animals. Addition of the primary sequence motifs to C. elegans pri-miRNAs promoted their efficient processing in human cells, underscoring the importance of these determinants. The identification and characterization of specific motifs greatly expands the understanding of the features that cells use to recognize pri-miRNAs, and opens the door to future studies of pri-miRNA recognition in humans and other bilaterian animals. In addition, the approach is applicable to the exploration of a variety of functional RNA elements that have so far resisted functional dissection, including long noncoding RNAs and messenger RNA localization signals.
by Vincent C. Auyeung.
Ph.D.

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34

Sailis, Fiammetta. "Detection of miRNA by SMART technology." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28891.

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Aberrant expression of short non-coding micro RNAs (miRNA) in many human diseases, along with remarkable stability in physiological media, has made them attractive clinical biomarkers. In particular, miRNA-122 is substantially elevated in plasma of patients with established drug-induced liver injury and can also be used to identify early liver injury when current markers, such as alanine aminotransferase (ALT), still show normal levels. The development of a rapid test for miRNA-122 e.g. in drug poisoning would allow earlier and more sensitive clinical diagnosis of liver injury. Nucleic acids are traditionally analysed by polymerase chain reaction (PCR), which has a high degree of sensitivity but suffers from high cost and is prone to sample contamination. The aim of this project is to develop a PCR free method to directly detect miRNA- 122 in biological samples using SMART technology. The SMART technology takes advantage of dynamic chemistry for sequence specific recognition of nucleic acids using aldehyde-modified nucleobases (SMART nucleobases), and target-complementary peptide nucleic acid (PNA) probe containing an “abasic” position (so called modified PNA probe). In this study, this unique detection method was used in a fluorescent detection with the use of light up probes, which are probes with an environmental dye as nucleobase; a FRET system was also designed to allow the discrimination between perfect match target and mismatched one. The SMART technology was also transferred onto magnetic beads to develop an ELISA like assay allowing sensitive and rapid detection of single stranded DNA mimic of the miRNA-122. With its potential PCR free approach, this easily adapted platform promises to transform and expand routine clinical diagnostic testing and screening for circulating miRNAs.

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Estell, Christopher. "Do erythrocytic miRNA have a function?" Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8899/.

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Despite being translationally null, erythrocytes contain miRNA at concentrations equal to nucleated cells, meaning that of the miRNA found in peripheral blood ~ 99 % is located in red cells. Despite this huge abundance, the literature currently regards erythrocytic miRNA (e-miRNA) as redundant. Data from Hamilton lab challenges this notion as it shows that e-miRNA are stable, maintain a catalytic potential, and have sequence profiles similar across species, indicating conservation. This thesis investigates what the potential function of emiRNA could be, both within erythrocytes and in other cells. To develop hypotheses, RISC-protein interactions were evaluated unearthing the appearance of an apparently post-translationally modified AGO2; what this modification is, remains to be defined. As part of a homeostatic hypothesis, the idea that e-miRNA may act as a molecular signal and regulate the transcriptome of phagocytosing cells was evaluated. However, it was discovered that e-miRNA are lost as RBCs age, potentially through vesicularisation. The differences between RBC vesicles that occur in vivo and those that occur when blood is stored ready for transfusion were evaluated. This highlighted a potential artefact within the literature with regards to what is termed as “microvesicles” (MVs). The clinical concern regarding storage MVs was evaluated through the generation of a phago/endocytosis model, and consistent with recent publications, no mal-effect was observed. This portion of the study highlighted a secondary structure within macrophages that is not a phagolysosome, but does process internalised RBC-MVs.

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36

Widdascheck, Mirko [Verfasser]. "Der Justizgewährleistungsanspruch des Dopingsünders. / Mirko Widdascheck." Berlin : Duncker & Humblot, 2018. http://d-nb.info/1238485529/34.

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Bou, Zeidan Nadim Georges. "Human miRNA Sequence Based Variations Database." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5350.

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MicroRNAs (miRNAs) are studied as key genetic elements that regulate the gene expression involved in different human diseases. Clinical sequence based variations like copy number variations (CNVs) affect miRNA biogenesis, dosage and target recognition that may represent potentially functional variants and relevant target bindings. To systematically analyze miRNA-related CNVs and their effects on related genes, a user-friendly free online database was developed to provide further analysis of co-localization of miRNA loci with human genome CNV regions. Further analysis pipelines such as miRNA-target to estimate the levels or locations of variations for genetic duplications, insertions or deletions were also offered. Such information could support the simulation of miRNA-target interactions.

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38

Shahab, Shubin. "Microrna and messenger rna interactions in ovarian cancer." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44753.

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Regulation of gene expression is a complex process in mammalian cells with many levels of control. In recent years non-coding RNAs in the form of microRNAs (miRNA) have surfaced as important regulators of protein coding genes, with biologically important roles in development, differentiation and cell growth. In this dissertation the complex interactions between miRNAs and mRNAs in ovarian cancer are investigated using a combination of computational and experimental techniques. In vitro studies and current models predict that increases in levels of miRNA should result in corresponding decreases in the levels of targeted mRNAs due to miRNA induced degradation. Profiling the global miRNA and mRNA expression patterns in epithelial ovarian cancer cells from patients and surface epithelial cells from normal ovaries reveal only ~11% of predicted targets of miRNAs are inversely correlated in vivo. In an effort to dissect the mechanisms behind these unexpected observations single miRNA transfection experiments are carried out followed by gene expression profiling. Analysis of genes altered following these transfections reveal majority of the altered genes are not direct targets of the miRNAs. Network analysis however suggests that miRNAs may target "hub genes" to cause altered expression in downstream transcripts. Pathway enrichment analysis of altered genes demonstrates miRNAs may regulate specific pathways rather than causing random off-target effects. Finally investigation of miRNA regulation reveals miRNAs may also affect the levels of other miRNAs, which may indirectly affect more genes downstream. Together these results provide a detailed view of the mechanisms employed by miRNAs to regulate the expression of hundreds of genes in ovarian cancer cells.

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Hinske, Ludwig Christian Giuseppe. "MiRNA Bioinformatik als Werkzeug medizinischer Forschung – Etablierung eines Datenbank- und Zielvorhersagesystems zur Bearbeitung von miRNA-bezogenen Fragestellungen." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-127971.

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40

Kaiser, Sascha [Verfasser], Mirko [Akademischer Betreuer] Hornung, Mirko [Gutachter] Hornung, and Anders [Gutachter] Lundbladh. "Multidisciplinary Design of Aeronautical Composite Cycle Engines / Sascha Kaiser ; Gutachter: Mirko Hornung, Anders Lundbladh ; Betreuer: Mirko Hornung." München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/1204199965/34.

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41

Hesse, Marlen. "Chemo-enzymatische Werkzeuge zur Untersuchung von nicht-codierender RNA." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät, 2017. http://dx.doi.org/10.18452/17740.

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Nicht-codierende RNAs sind ein bedeutender Bestandteil genregulatorischer Prozesse. Ihre Fehlregulierung wird mit zellulärer Dysfunktion und der Entstehung von Krankheiten in Zusammenhang gebracht. Ziel dieser Arbeit war die Entwicklung verschiedener Testsysteme zur Untersuchung nicht codierender RNAs mit dem Schwerpunkt microRNA (miRNA), precursor miRNA (pre-miRNA) und circular RNA (circRNA). Für eine Zyklisierung und Funktionalisierung von circRNA mittels Cu-katalysierter Click-Chemie zur Identifizierung zellulärer Interaktionspartner und zugehöriger Wirkmechanismen wurden die Termini linearer RNA-Template modifiziert. Mit Hilfe enzymatischer Techniken wie Transkription und Ligation konnte in vitro die Inkorporation Azid- und Alkin-funktionalisierter Nukleotid-Bausteine am 5‘- und 3‘-Terminus gezeigt werden. Zur Untersuchung der miRNA-Reifung in cellulo wurde die pre-miRNA-134 unter Verwendung chemo-enzymatischer Methoden mit einem Fluorophor/Quencher-Paar an den Termini ausgestattet. Durch intrazelluläre Reifung der gelabelten pre-miRNA mit einhergehender Fluoreszenzfreisetzung sollte die Visualisierung und damit die Lokalisierung des miRNA-Reifungsortes innerhalb von Neuronen realisiert werden. Zudem gelang die Entwicklung eines auf branched rolling-circle amplification (BRCA) basierenden Argonaute2(Ago2)-vermittelten Spaltungsassays. Ein Enzymkomplex aus rekombinantem, humanem Ago2 und der miRNA miR 122, genannt minimal RISC, wurde dabei zur Substrat-Spaltung eingesetzt. Zur Etablierung des BRCA-basierenden Ago2-vermittelten Spaltungsassays als Screening-Tool für die Identifizierung potentieller Inhibitoren der mRNA-Spaltung wurden exemplarisch sechs Testsubstanzen aus der Gruppe der Aminoglykoside untersucht. Der BRCA-basierende Ago2-vermittelte Spaltungsassay stellte eine einfache und zuverlässige Detektionsmethode dar, der die Untersuchung einer größeren Probenzahl mit geringem Aufwand und ohne Verwendung von fluorogen gelabeltem Substrat ermöglichte.
Non-coding RNAs are an important factor in gene regulation in which their deregulation is associated with cellular dysfunction and disease. Here, the development of different test systems for the investigation of non-coding RNAs, namely microRNA (miRNA), precursor miRNA (pre-miRNA), and circular RNA (circRNA), was on focus. In order to circularize and functionalize circRNA with the purpose of identifying cellular interaction partners and possible mechanisms of action, 5‘- and 3‘-terminal modifications were added to a linear RNA template. This was accomplished by using azide- and alkyne-functionalized nucleotides which were incorporated by enzymatic approaches like transcription and ligation to be followed by Cu-catalyzed click chemistry for circularization. For investigating miRNA maturation in neuronal cells, pre-miR-134 was modified by chemo-enzymatic approach with fluorophore and quencher at its 5‘ and 3‘ ends, respectively. Intracellular maturation of labeled pre-miRNA would produce a fluorescent signal upon cleavage, thus enabling visualization and localization of miRNA maturation in neuronal cells. Furthermore, the development of Ago2-mediated mRNA cleavage assay based on branched rolling-circle amplification (BRCA) was accomplished. A complex of recombinant human Ago2 and miRNA miR-122, called minimal RISC, was used for substrate cleavage. To establish this assay as adequate screening method for identifying potential inhibitors of mRNA cleavage, a group of six aminoglycosides was tested. The BRCA-based Ago2-mediated cleavage assay showed to be a simple and reliable detection method and screening tool for small molecule binders with little effort and without fluorescent labeling of substrate.

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Nyman, Henri. "Hallonbåtsflyktingen i mellanmjölkens hemland. Vadelmavenepakolainen Folkhemmetin vieraana. : Tutkimus Miika Nousiaisen romaanin vastaanotosta Ruotsissa. En undersökning av Miika Nousiainens romans mottagande i Sverige." Thesis, Stockholms universitet, Institutionen för baltiska språk, finska och tyska, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-52065.

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43

Santander, Leal Juan. "Monsieur Pain mira a Vallejo." Tesis, Universidad de Chile, 2006. http://repositorio.uchile.cl/handle/2250/110321.

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Este trabajo trata sobre la mirada, el ojo, la mirilla y el anteojo como metáforas del vislumbre (ver apenas, ver mal) del protagonista de la novela de Roberto Bolaño Monsieur Pain, y de la lectura que intento plantear de ésta. Trata sobre la relación ojo-mirilla y como sólo es posible para el personaje Pierre Pain ver a través de la mirilla atenta.

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44

Schömann, Joachim [Verfasser], Mirko [Akademischer Betreuer] Hornung, and Horst [Akademischer Betreuer] Baier. "Hybrid-electric propulsion systems for small unmanned aircraft / Joachim Schömann. Gutachter: Mirko Hornung ; Horst Baier. Betreuer: Mirko Hornung." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1063724023/34.

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45

Randt, Niclas Peter [Verfasser], Mirko [Akademischer Betreuer] [Gutachter] Hornung, and Eike [Gutachter] Stumpf. "Aircraft Technology Assessment Using Fleet-Level Metrics / Niclas Peter Randt ; Gutachter: Mirko Hornung, Eike Stumpf ; Betreuer: Mirko Hornung." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1120013631/34.

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46

Schmidt, Michael [Verfasser], Mirko [Akademischer Betreuer] Hornung, Mirko [Gutachter] Hornung, and Klaus [Gutachter] Bengler. "Ground-Operational Assessment of Novel Aircraft Cabin Configurations / Michael Schmidt ; Gutachter: Mirko Hornung, Klaus Bengler ; Betreuer: Mirko Hornung." München : Universitätsbibliothek der TU München, 2018. http://d-nb.info/1158894155/34.

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47

Wagner, Mirko [Verfasser]. "Dataloggerbasierte Kundenkollektivermittlung für die Fahrzeugerprobung / Mirko Wagner." Aachen : Shaker, 2017. http://d-nb.info/1138177768/34.

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48

Bruch, Richard [Verfasser], and Gerald A. [Akademischer Betreuer] Urban. "Multiplexed miRNA biosensor for pediatric cancer diagnostics." Freiburg : Universität, 2019. http://d-nb.info/1209052253/34.

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49

Hutagalung, Milka [Verfasser]. "Buffered Simulation for Büchi Automata / Milka Hutagalung." Kassel : Universitätsbibliothek Kassel, 2019. http://d-nb.info/1199317128/34.

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Filipchyk, Andrei. "Identification and Characterization of miRNA regulatory networks." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20479.

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Post-transkriptionelle Genregulation ist ein zentraler Mechanismus, den lebende Organismen nutzen, um Funktionalität, Entwicklung und Anpassung zu gewährleisten. Defizite in diesem Mechanismus haben zahlreiche Krankheiten und Fehlfunktionen zur Folge. Post-transkriptionelle Genregulation wird von RNA-bindenden Proteinen (RBPs) ausgeführt. Ihr kombinatorisches Agieren ermöglicht eine genau abgestimmte Kontrolle räumlicher und zeitlicher Genexpression. Ein RBP erkennt seine Zielmoleküle typischerweise anhand sogenannter Bindemotive: Nukleotidsequenzen, die kompatibel sind mit einer Aminosäuretasche innerhalb des Proteins. Es gibt jedoch einen Sonderfall der Zielmolekülerkennung, der überRNAs, insbesondere microRNAs (miRNAs), vermittelt wird. miRNAs sind im Genom kodierte 20-25 Nukleotid lange RNAs, die in Argonaut (Ago)-Proteine geladen werden können, um diese zu ihren Zielmolekülen (z.B mRNAs) zu navigieren. Es wird angenommen, dass miRNA:Ago-Komplexe nahezu alle zellulären Prozesse kontrollieren. Dementsprechend werden miRNA-Fehlfunktionen (z.B. verursacht durch Mutation nur eines einzelnen Nukleotids in einer Bindestelle) mit zahlreichen Erkrankungen in Verbindung gebracht. Die Charakterisierung aller miRNA-Zielmoleküle („miRNA targetome“) ist eine der wichtigsten Fragen, die mithilfe der Systembiologie adressiert werden kann.
Post-transcriptional gene regulation is a key mechanism exploited by living organisms to ensure their functionality, development and adaptation. Deficiencies in this mechanism lead to various diseases and malfunctions. Post-transcriptional gene regulation is exerted by RNA-binding proteins (RBPs). Their combinatorial action allows fine-tuned control over spatial and temporal gene expression to meet the actual cell demands. An RBP typically recognizes its targets via so called binding motifs: nucleotide sequences compatible with an amino-acid pocket inside the protein. However, there is a special case of target recognition guided by RNAs. In particular, micro RNAs(miRNAs) – 20-25 nucleotide long transcripts encoded in the genome–can be loaded into Argonaute (Ago) proteins to navigate them to their target RNAs. It is estimated that miRNA:Ago complexes control virtually all processes occurring in the cell. Consequently, malfunctions in the miRNA pathway (including even a single nucleotide mutation in a binding site) are implicated in multiple disorders. Therefore, the characterization of the “miRNA targetome” is one of the most important questions addressed to the systems biology

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