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Journal articles on the topic 'MiR486'

Author: Grafiati

Published: 14 March 2023

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1

Karagun, Barbaros Sahin, Bulent Antmen, Ilgen Sasmaz, Kahraman Tanriverdi, Gulsum Ucar, and Yurdanur Kilinc. "Micro-RNA Profile of Childhood Acute Lymphoblastic Leukemia." Blood 120, no. 21 (2012): 4824. http://dx.doi.org/10.1182/blood.v120.21.4824.4824.

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Abstract Abstract 4824 Micro-RNAs are functional, non-protein coding RNA molecules and their transcriptions provided by intron or exon regions of the genome and non-protein coding regions of RNA genes. The role of micro-RNAs in acute leukemia has become the subject of research increasingly. In this study we aimed to identify micro-RNA profiles in the childhood acute leukemia that one of hematologic malignancies. Fourty nine patients who were diagnosed with acute leukemia and admitted to Cukurova University Faculty of Medicine Department of Pediatric Hematology between December 2010 and Septemb

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Cao, Chunyu, Ruicai Long, Tiejun Zhang, et al. "Genome-Wide Identification of microRNAs in Response to Salt/Alkali Stress in Medicago truncatula through High-Throughput Sequencing." International Journal of Molecular Sciences 19, no. 12 (2018): 4076. http://dx.doi.org/10.3390/ijms19124076.

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Saline-alkaline stress is a universal abiotic stress that adversely affects plant growth and productivity. Saline-alkaline conditions results in plant abnormal transcriptome expression finally manifesting as defective phenotypes. Considerable research has revealed the active role of microRNA in various stress conditions. This study was aimed to identify novel miRNAs and the miRNA expression patterns in the leguminous model plant R108 (Medicago truncatula). The miRNA contained in the total RNA extracted from Medicago truncatula seedlings (72 h) that had been treated with solutions mimicking sal

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Narducci, M. G., D. Arcelli, M. C. Picchio, et al. "MicroRNA profiling reveals that miR-21, miR486 and miR-214 are upregulated and involved in cell survival in Sézary syndrome." Cell Death & Disease 2, no. 4 (2011): e151-e151. http://dx.doi.org/10.1038/cddis.2011.32.

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Cao, Huiying, Xinyue Zhang, Yanye Ruan, et al. "miRNA expression profiling and zeatin dynamic changes in a new model system of in vivo indirect regeneration of tomato." PLOS ONE 15, no. 12 (2020): e0237690. http://dx.doi.org/10.1371/journal.pone.0237690.

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Callus formation and adventitious shoot differentiation could be observed on the cut surface of completely decapitated tomato plants. We propose that this process can be used as a model system to investigate the mechanisms that regulate indirect regeneration of higher plants without the addition of exogenous hormones. This study analyzed the patterns of trans-zeatin and miRNA expression during in vivo regeneration of tomato. Analysis of trans-zeatin revealed that the hormone cytokinin played an important role in in vivo regeneration of tomato. Among 183 miRNAs and 1168 predicted target genes s

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Ding, Yueyun, Yinhui Hou, Zijing Ling, et al. "Identification of Candidate Genes and Regulatory Competitive Endogenous RNA (ceRNA) Networks Underlying Intramuscular Fat Content in Yorkshire Pigs with Extreme Fat Deposition Phenotypes." International Journal of Molecular Sciences 23, no. 20 (2022): 12596. http://dx.doi.org/10.3390/ijms232012596.

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Intramuscular fat (IMF) content is vital for pork quality, serving an important role in economic performance in pig industry. Non-coding RNAs, with mRNAs, are involved in IMF deposition; however, their functions and regulatory mechanisms in porcine IMF remain elusive. This study assessed the whole transcriptome expression profiles of the Longissimus dorsi muscle of pigs with high (H) and low (L) IMF content to identify genes implicated in porcine IMF adipogenesis and their regulatory functions. Hundreds of differentially expressed RNAs were found to be involved in fatty acid metabolic processe

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Ma, Jingyi, Pan Zhao, Shibiao Liu, Qi Yang, and Huihong Guo. "The Control of Developmental Phase Transitions by microRNAs and Their Targets in Seed Plants." International Journal of Molecular Sciences 21, no. 6 (2020): 1971. http://dx.doi.org/10.3390/ijms21061971.

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Seed plants usually undergo various developmental phase transitions throughout their lifespan, mainly including juvenile-to-adult and vegetative-to-reproductive transitions, as well as developmental transitions within organ/tissue formation. MicroRNAs (miRNAs), as a class of small endogenous non-coding RNAs, are involved in the developmental phase transitions in plants by negatively regulating the expression of their target genes at the post-transcriptional level. In recent years, cumulative evidence has revealed that five miRNAs, miR156, miR159, miR166, miR172, and miR396, are key regulators

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Seyyedi, Samaneh Sadat, Masoud Soleimani, Marjan Yaghmaie, et al. "Deregulation of miR-1, miR486, and let-7a in cytogenetically normal acute myeloid leukemia: association with NPM1 and FLT3 mutation and clinical characteristics." Tumor Biology 37, no. 4 (2015): 4841–47. http://dx.doi.org/10.1007/s13277-015-4289-y.

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Puchta, Marta, Jolanta Groszyk, Magdalena Małecka, et al. "Barley Seeds miRNome Stability during Long-Term Storage and Aging." International Journal of Molecular Sciences 22, no. 9 (2021): 4315. http://dx.doi.org/10.3390/ijms22094315.

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Seed aging is a complex biological process that has been attracting scientists’ attention for many years. High-throughput small RNA sequencing was applied to examine microRNAs contribution in barley seeds senescence. Unique samples of seeds that, despite having the same genetic makeup, differed in viability after over 45 years of storage in a dry state were investigated. In total, 61 known and 81 novel miRNA were identified in dry seeds. The highest level of expression was found in four conserved miRNA families, i.e., miR159, miR156, miR166, and miR168. However, the most astonishing result was

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Salih, Haron, Wenfang Gong, Mtawa Mkulama, and Xiongming Du. "Genome-wide characterization, identification, and expression analysis of the WD40 protein family in cotton." Genome 61, no. 7 (2018): 539–47. http://dx.doi.org/10.1139/gen-2017-0237.

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WD40 repeat proteins are largely distributed across the plant kingdom and play an important role in diverse biological activities. In this work, we performed genome-wide identification, characterization, and expression level analysis of WD40 genes in cotton. A total of 579, 318, and 313 WD40 genes were found in Gossypium hirsutum, G. arboreum, and G. raimondii, respectively. Based on phylogenetic tree analyses, WD40 genes were divided into 11 groups with high similarities in exon/intron features and protein domains within the group. Expression analysis of WD40 genes showed differential express

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Gao, Shiwu, Yingying Yang, Yuting Yang, et al. "Identification of Low-Nitrogen-Related miRNAs and Their Target Genes in Sugarcane and the Role of miR156 in Nitrogen Assimilation." International Journal of Molecular Sciences 23, no. 21 (2022): 13187. http://dx.doi.org/10.3390/ijms232113187.

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Chemical nitrogen (N) fertilizer is widely used in sugarcane production, especially in China and India. Understanding the molecular mechanisms and mining miRNAs and their target genes associated with nitrogen use efficiency (NUE) in sugarcane can aid in developing the N-efficient varieties, and thus is beneficial to reduce N fertilizer application. In this study, the root miRNA database of N-efficient sugarcane variety ROC22 under low N stress (0.3 mM NH4NO3) for 3 h was constructed, along with their transcriptome-rearranged data. KEGG analysis indicated that those candidate target genes, corr

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Liu, LingLing, Chao Fang, YinZe Sun, and WuJun Liu. "Evaluation of key miRNAs during early pregnancy in Kazakh horse using RNA sequencing." PeerJ 9 (February 23, 2021): e10796. http://dx.doi.org/10.7717/peerj.10796.

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Background miRNA has an important role in cell differentiation, biological development, and physiology. Milk production is an important quantitative trait in livestock and miRNA plays a role in the amount of milk produced. Methods The role of regulatory miRNAs involved in equine milk production is not fully understood. We constructed two miRNA libraries for Kazakh horse milk production from higher-producing (H group) and lower-producing (L group) individuals, and used RNA-Seq technology to identify the differentially expressed miRNAs between the two milk phenotypes of Kazakh horses. Results A

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Wang, Li-Sheng, Ling Li, Liang Li, et al. "Role of MicroRNA-486-5p Overexpression In CML CD34+ Cells In Modulating BCR-ABL Mediated Hematopoietic Stem/Progenitor Cell Transformation and Imatinib Sensitivity." Blood 118, no. 21 (2011): 1667. http://dx.doi.org/10.1182/blood.v118.21.1667.1667.

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Abstract Abstract 1667 MicroRNAs are key regulators of gene expression that regulate normal differentiation and contribute to malignant transformation of hematopoietic cells. Using microRNA microarrays we identified increased expression of miR-486 in chronic myeloid leukemia (CML) compared to normal CD34+ cells. In both normal and CML cells, miR-486 expression level was significantly higher in MEP compared to HSC, GMP and CMP populations. Treatment with Imatinib resulted in reduced expression of miR-486-5p in CML CD34+ cells, suggesting that upregulation of miR-486-5p expression was at least i

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Perea-García, Ana, Amparo Andrés-Bordería, Peter Huijser, and Lola Peñarrubia. "The Copper-microRNA Pathway Is Integrated with Developmental and Environmental Stress Responses in Arabidopsis thaliana." International Journal of Molecular Sciences 22, no. 17 (2021): 9547. http://dx.doi.org/10.3390/ijms22179547.

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As an essential nutrient, copper (Cu) scarcity causes a decrease in agricultural production. Cu deficiency responses include the induction of several microRNAs, known as Cu-miRNAs, which are responsible for degrading mRNAs from abundant and dispensable cuproproteins to economize copper when scarce. Cu-miRNAs, such as miR398 and miR408 are conserved, as well as the signal transduction pathway to induce them under Cu deficiency. The Arabidopsis thaliana SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE (SPL) family member SPL7 binds to the cis-regulatory motifs present in the promoter regions of genes expr

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López-Ruiz, Brenda A., Vasti T. Juárez-González, Estela Sandoval-Zapotitla, and Tzvetanka D. Dinkova. "Development-Related miRNA Expression and Target Regulation during Staggered In Vitro Plant Regeneration of Tuxpeño VS-535 Maize Cultivar." International Journal of Molecular Sciences 20, no. 9 (2019): 2079. http://dx.doi.org/10.3390/ijms20092079.

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In vitro plant regeneration addresses basic questions of molecular reprogramming in the absence of embryonic positional cues. The process is highly dependent on the genotype and explant characteristics. However, the regulatory mechanisms operating during organ differentiation from in vitro cultures remain largely unknown. Recently, miRNAs have emerged as key regulators during embryogenic callus induction, plant differentiation, auxin responses and totipotency. Here, we explored how development-related miRNA switches the impact on their target regulation depending on physiological and molecular

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Taier, Geli, Nan Hang, Tianran Shi, et al. "Ectopic Expression of Os-miR408 Improves Thermo-Tolerance of Perennial Ryegrass." Agronomy 11, no. 10 (2021): 1930. http://dx.doi.org/10.3390/agronomy11101930.

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With global warming, high temperature stress has become a main threat to the growth of cool-season turfgrasses, including perennial ryegrass. As one of the conserved plant microRNA families, miR408s are known to play roles in various abiotic stresses, including cold, drought, salinity, and oxidative stress, but no report, thus far, was found for heat. Here, perennial ryegrass plants overexpressing rice Os-miR408 were used to investigate the role of miR408 in plant heat tolerance. Both wild type (WT) and miR408 transgenic perennial ryegrass plants (TG) were subjected to short-term heat stress a

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Liu, Hongyu, Ibrar Muhammad Khan, Yong Liu, et al. "A Comprehensive Sequencing Analysis of Testis-Born miRNAs in Immature and Mature Indigenous Wandong Cattle (Bos taurus)." Genes 13, no. 12 (2022): 2185. http://dx.doi.org/10.3390/genes13122185.

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Micro RNAs (miRNAs) have been recognized as important regulators that are indispensable for testicular development and spermatogenesis. miRNAs are endogenous transcriptomic elements and mainly regulate the gene expression at post-transcriptional levels; however, the key role of miRNA in bovine testicular growth is not clearly understood. Thus, supposing to unveil the transcriptomics expression changes in the developmental processes of bovine testes, we selected three immature calves and three sexually mature bulls of the local Wandong breed for testicular-tissue sample collection. The cDNA lib

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Tang, Qi, Haozhe Lv, Qimeng Li, et al. "Characteristics of microRNAs and Target Genes in Maize Root under Drought Stress." International Journal of Molecular Sciences 23, no. 9 (2022): 4968. http://dx.doi.org/10.3390/ijms23094968.

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Maize (Zea mays) is an important multi-functional crop. The growth and yield of maize are severely affected by drought stress. Previous studies have shown that microRNAs (miRNAs) in maize play important roles in response to abiotic stress; however, their roles in response to drought stress in maize roots is unclear. In our study, we found 375 miRNAs in the roots of 16 inbred lines. Of the 16 lines, zma-MIR168, zma-MIR156, and zma-MIR166 were highly expressed, whereas zma-MIR399, zma-MIR2218, and zma-MIR2275 exhibited low expression levels. The expression patterns of miRNA in parental lines and

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Yrondi, Antoine, Laura M. Fiori, Benicio N. Frey, et al. "Association Between Side Effects and Blood microRNA Expression Levels and Their Targeted Pathways in Patients With Major Depressive Disorder Treated by a Selective Serotonin Reuptake Inhibitor, Escitalopram: A CAN-BIND-1 Report." International Journal of Neuropsychopharmacology 23, no. 2 (2019): 88–95. http://dx.doi.org/10.1093/ijnp/pyz066.

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Abstract Introduction Antidepressant drugs are effective therapies for major depressive disorder; however, they are frequently associated with side effects. Although there is some evidence for a relationship between genetic variation and side effects, little is known regarding the role of dynamic molecular factors as moderators of side effects. The aim of this study was to assess microRNA (miRNA) changes associated with side effects during escitalopram treatment and their downstream effects on target gene expression. Methods A total 160 patients with major depressive disorder from the CAN-BIND

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Luo, Ming, Xinyuan Sun, Meng Xu, and Zhendong Tian. "Identification of miRNAs Involving Potato-Phytophthora infestans Interaction." Plants 12, no. 3 (2023): 461. http://dx.doi.org/10.3390/plants12030461.

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sRNAs (small RNAs) play an important role in regulation of plant immunity against a variety of pathogens. In this study, sRNA sequencing analysis was performed to identify miRNAs (microRNAs) during the interaction of potato and Phytophthora infestans. Totally, 171 potato miRNAs were identified, 43 of which were annotated in the miRNA database and 128 were assigned as novel miRNAs in this study. Those potato miRNAs may target 878 potato genes and half of them encode resistance proteins. Fifty-three potato miRNAs may target 194 P. infestans genes. Three potato miRNAs (novel 72, 133, and 140) wer

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de Vries, Sophie, Andreas Kukuk, Janina K. von Dahlen, Anika Schnake, Thorsten Kloesges, and Laura E. Rose. "Expression profiling across wild and cultivated tomatoes supports the relevance of early miR482/2118 suppression for Phytophthora resistance." Proceedings of the Royal Society B: Biological Sciences 285, no. 1873 (2018): 20172560. http://dx.doi.org/10.1098/rspb.2017.2560.

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Plants possess a battery of specific pathogen resistance ( R- )genes. Precise R- gene regulation is important in the presence and absence of a pathogen. Recently, a microRNA family, miR482/2118, was shown to regulate the expression of a major class of R- genes , nucleotide-binding site leucine-rich repeats ( NBS-LRRs ). Furthermore, RNA silencing suppressor proteins, secreted by pathogens, prevent the accumulation of miR482/2118, leading to an upregulation of R- genes. Despite this transcriptional release of R -genes, RNA silencing suppressors positively contribute to the virulence of some pat

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Kang, Qingzheng, Yin Tong, Vemana Gowd, Mingfu Wang, Feng Chen, and Ka-Wing Cheng. "Oral administration of EGCG solution equivalent to daily achievable dosages of regular tea drinkers effectively suppresses miR483-3p induced metastasis of hepatocellular carcinoma cells in mice." Food & Function 12, no. 8 (2021): 3381–92. http://dx.doi.org/10.1039/d1fo00664a.

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Yuan, Zhaodi, Jihong Pan, Congping Chen, et al. "DRB2 Modulates Leaf Rolling by Regulating Accumulation of MicroRNAs Related to Leaf Development in Rice." International Journal of Molecular Sciences 23, no. 19 (2022): 11147. http://dx.doi.org/10.3390/ijms231911147.

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As an important agronomic trait in rice (Oryza sativa), moderate leaf rolling helps to maintain the erectness of leaves and minimize shadowing between leaves, leading to improved photosynthetic efficiency and grain yield. However, the molecular mechanisms underlying rice leaf rolling still need to be elucidated. Here, we isolated a rice mutant, rl89, showing adaxially rolled leaf phenotype due to decreased number and size of bulliform cells. We confirmed that the rl89 phenotypes were caused by a single nucleotide substitution in OsDRB2 (LOC_Os10g33970) gene encoding DOUBLE-STRANDED RNA-BINDING

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Sun, Qiang, Xueyi Gong, Jianlong Wu, et al. "Effect of lncRNA PVT1/miR186/KLF5 Axis on the Occurrence and Progression of Cholangiocarcinoma." BioMed Research International 2021 (July 10, 2021): 1–10. http://dx.doi.org/10.1155/2021/8893652.

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This study primarily focused on the effect of the long noncoding RNA (lncRNA) PVT1/miR186/KLF5 axis on the occurrence and progression of cholangiocarcinoma (CCA). miR186 was found both in the lncRNA PVT1 targeting miRNAs and KLF5 targeting miRNAs using bioinformatic analysis. The expression of lncRNA PVT1 and KLF5 in the TFK-1, QBC939, and HuCCT1 cell lines and normal biliary epithelial HIBEpiC cells was detected by RT-qPCR. The significance of lncRNA PVT1 and KLF5 on cell proliferation was analyzed using the MTT assay and clone formation assay in lncRNA PVT1 and KLF5 silencing HuCCT1 cell lin

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Ražná, Katarína, Janka Nôžková, Lucia Hlavačková, et al. "Genotyping of Flax Genetic Resources by Mirna-Based Molecular Markers and Morphology." Agriculture (Polnohospodárstvo) 61, no. 4 (2015): 129–38. http://dx.doi.org/10.1515/agri-2015-0018.

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Abstract MicroRNAs (miRNAs) are a class of non-coding RNAs about 20-24 nucleotides long. They play an important role in the gene regulation at the post-transcriptional level. They affect the plant genome response to environmental stress. The miRNA-based molecular markers is type of functional markers reported in very few plants. However, the information connected to the evaluation of genotypes by this type of markers within a single species is missing. Considering the stability, polymorphism, functionality and transferability potential of miRNA-based markers, the research was conducted to appl

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Canto-Pastor, Alex, Bruno A. M. C. Santos, Adrian A. Valli, William Summers, Sebastian Schornack, and David C. Baulcombe. "Enhanced resistance to bacterial and oomycete pathogens by short tandem target mimic RNAs in tomato." Proceedings of the National Academy of Sciences 116, no. 7 (2019): 2755–60. http://dx.doi.org/10.1073/pnas.1814380116.

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Nucleotide binding site leucine-rich repeat (NLR) proteins of the plant innate immune system are negatively regulated by the miR482/2118 family miRNAs that are in a distinct 22-nt class of miRNAs with a double mode of action. First, they cleave the target RNA, as with the canonical 21-nt miRNAs, and second, they trigger secondary siRNA production using the target RNA as a template. Here, we address the extent to which the miR482/2118 family affects expression of NLR mRNAs and disease resistance. We show that structural differences of miR482/2118 family members in tomato (Solanum lycopersicum)

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Chen, Jin, Ao Pan, Shujun He, et al. "Different MicroRNA Families Involved in Regulating High Temperature Stress Response during Cotton (Gossypium hirsutum L.) Anther Development." International Journal of Molecular Sciences 21, no. 4 (2020): 1280. http://dx.doi.org/10.3390/ijms21041280.

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MicroRNAs (miRNAs) are small molecule RNAs widely involved in responses to plant abiotic stresses. We performed small RNA sequencing of cotton anthers at four developmental stages under normal and high temperature (NT and HT, respectively) conditions to investigate the stress response characteristics of miRNA to HT. A total of 77 miRNAs, including 33 known miRNAs and 44 novel miRNAs, were identified, and 41 and 28 miRNAs were differentially expressed under NT and HT stress conditions, respectively. The sporogenous cell proliferation (SCP), meiotic phase (MP), microspore release period (MRP), a

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Yang, Fan, Dan Zhao, Haiyan Fan, et al. "Functional Analysis of Long Non-Coding RNAs Reveal Their Novel Roles in Biocontrol of Bacteria-Induced Tomato Resistance to Meloidogyne incognita." International Journal of Molecular Sciences 21, no. 3 (2020): 911. http://dx.doi.org/10.3390/ijms21030911.

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Root-knot nematodes (RKNs) severely affect plants growth and productivity, and several commercial biocontrol bacteria can improve plants resistance to RKNs. Pseudomonas putida Sneb821 isolate was found to induce tomatoes resistance against Meloidogyne incognita. However, the molecular functions behind induced resistance remains unclear. Long non-coding RNA (lncRNA) is considered to be a new component that regulates the molecular functions of plant immunity. We found lncRNA was involved in Sneb821-induced tomato resistance to M. incognita. Compared with tomato inoculated with M. incognita, high

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Shehzad, Muhammad, Zhongli Zhou, Allah Ditta, et al. "Identification and characterization of genes related to salt stress tolerance within segregation distortion regions of genetic map in F2 population of upland cotton." PLOS ONE 16, no. 3 (2021): e0247593. http://dx.doi.org/10.1371/journal.pone.0247593.

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Segregation distortion (SD) is a genetic mechanism commonly found in segregating or stable populations. The principle behind this puzzles many researchers. The F2generation developed from wildGossypium darwiniiandG.hirsutumCCRI12 species was used to investigate the possible transcription factors within the segregation distortion regions (SDRs). The 384 out of 2763 markers were distorted in 29 SDRs on 18 chromosomes. Good collinearity was observed among genetic and physical maps ofG.hirsutumandG.barbadensesyntenic blocks. Total 568 genes were identified from SDRs of 18 chromosomes. Out of these

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Bakhshi, Behnam, and Ehsan Mohseni Fard. "Whole Aegilops tauschii Transcriptome Investigation Revealed Nine Novel miRNAs Involved in Stress Response." Current Bioinformatics 15, no. 5 (2020): 455–62. http://dx.doi.org/10.2174/1574893614666191017151708.

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Background: Aegilops tauschii is a wild relative of bread wheat. This species has been reported as the donor of bread wheat D genome. There are also several reports that mentioned the importance of Ae. tauschii in biotic and abiotic stress tolerance. On the other hands, miRNAs have been reported as the essential regulatory elements in stress response. Objective: Therefore, it is important to discover novel miRNAs involved in stress tolerance in this species. The aim of the current study was to predict novel miRNAs in Ae. tauschii and also uncover their potential role in stress response. Method

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Gorshkov, Oleg, Tatyana Chernova, Natalia Mokshina, et al. "Intrusive Growth of Phloem Fibers in Flax Stem: Integrated Analysis of miRNA and mRNA Expression Profiles." Plants 8, no. 2 (2019): 47. http://dx.doi.org/10.3390/plants8020047.

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Phloem fibers are important elements of plant architecture and the target product of many fiber crops. A key stage in fiber development is intrusive elongation, the mechanisms of which are largely unknown. Integrated analysis of miRNA and mRNA expression profiles in intrusivelygrowing fibers obtained by laser microdissection from flax (Linum usitatissimum L.) stem revealed all 124 known flax miRNA from 23 gene families and the potential targets of differentially expressed miRNAs. A comparison of the expression between phloem fibers at different developmental stages, and parenchyma and xylem ti

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Xu, Pan, Quanqing Li, Weiqing Liang, et al. "A tissue-specific profile of miRNAs and their targets related to paeoniaflorin and monoterpenoids biosynthesis in Paeonia lactiflora Pall. by transcriptome, small RNAs and degradome sequencing." PLOS ONE 18, no. 1 (2023): e0279992. http://dx.doi.org/10.1371/journal.pone.0279992.

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Paeonia lactiflora Pall. (Paeonia) has aroused many concerns due to its extensive medicinal value, in which monoterpene glucoside paeoniflorin and its derivatives are the active chemical components. However, little is known in the molecular mechanism of monoterpenoids biosynthesis, and the regulation network between small RNAs and mRNAs in monoterpenoids biosynthesis has not been investigated yet. Herein, we attempted to reveal the tissue-specific regulation network of miRNAs and their targets related to paeoniaflorin and monoterpenoids biosynthesis in Paeonia by combining mRNA and miRNA expre

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Jia, Fan, and Christopher D. Rock. "Jacalin LectinAt5g28520Is Regulated By ABA and miR846." Plant Signaling & Behavior 8, no. 6 (2013): e24563. http://dx.doi.org/10.4161/psb.24563.

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Dalmadi, Ágnes, Fabio Miloro, Jeannette Bálint, Éva Várallyay, and Zoltán Havelda. "Controlled RISC loading efficiency of miR168 defined by miRNA duplex structure adjusts ARGONAUTE1 homeostasis." Nucleic Acids Research 49, no. 22 (2021): 12912–28. http://dx.doi.org/10.1093/nar/gkab1138.

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Abstract Micro RNAs (miRNAs) are processed from precursor RNA molecules with precisely defined secondary stem-loop structures. ARGONAUTE1 (AGO1) is the main executor component of miRNA pathway and its expression is controlled via the auto-regulatory feedback loop activity of miR168 in plants. Previously we have shown that AGO1 loading of miR168 is strongly restricted leading to abundant cytoplasmic accumulation of AGO-unbound miR168. Here, we report, that intrinsic RNA secondary structure of MIR168a precursor not only defines the processing of miR168, but also precisely adjusts AGO1 loading ef

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Feng, Yaxing, Nawei Qi, Piao Lei, et al. "Gma-miR408 Enhances Soybean Cyst Nematode Susceptibility by Suppressing Reactive Oxygen Species Accumulation." International Journal of Molecular Sciences 23, no. 22 (2022): 14022. http://dx.doi.org/10.3390/ijms232214022.

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Soybean cyst nematode (SCN, Heterodera glycine) is a serious damaging disease in soybean worldwide, thus resulting in severe yield losses. MicroRNA408 (miR408) is an ancient and highly conserved miRNA involved in regulating plant growth, development, biotic and abiotic stress response. Here, we analyzed the evolution of miR408 in plants and verified four miR408 members in Glycine max. In the current research, highly upregulated gma-miR408 expressing was detected during nematode migration and syncytium formation response to soybean cyst nematode infection. Overexpressing and silencing miR408 ve

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Vijayaraghavan, Bhooma, Sridharan Jeyamohan, Giri Padmanabhan, Antony Joseph Velangann, and Kumaresan Ramanathan. "Circulatory microRNA expression profile for coronary artery calcification in chronic kidney disease patients." African Health Sciences 21, no. 2 (2021): 728–34. http://dx.doi.org/10.4314/ahs.v21i2.31.

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Background & Aim: Coronary artery disease (CAD) is the primary cause of mortality in patients with end stage renal disease (ESRD). MicroRNA profiling is proven as a powerful tool in the diagnosis of any disease at the molecular level. Hence, the present study aimed to profile the microRNA expression for CAD especially coronary artery calcification in CKD patients. Materials and Methods: Two hundread patients with CKD stages 3 to 5 without dialysis and healthy controls were includ- ed in this study. All two hundred patients underwent 1024 multi sliceardiac computed tomography (CT) sca

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Mo, Zhenghai, Gang Feng, Wenchuan Su, Zhuangzhuang Liu, and Fangren Peng. "Identification of miRNAs Associated with Graft Union Development in Pecan [Carya illinoinensis (Wangenh.) K. Koch]." Forests 9, no. 8 (2018): 472. http://dx.doi.org/10.3390/f9080472.

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Pecan [Carya illinoinensis (Wangenh.) K. Koch] is a high-value fruit tree with a long juvenile period. The fruiting process of pecan seedlings can be largely accelerated through grafting. As non-coding small RNAs, plant miRNAs participate in various biological processes through negative regulation of gene expression. To reveal the roles of miRNAs in the graft union development of pecan, four small RNA libraries were constructed from the graft union at days 0, 8, 15, and 30 after grafting. A total of 47 conserved miRNAs belonging to 31 families and 39 novel miRNAs were identified. For identifie

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Ražná, Katarína, Vladimír Rataj, Miroslav Macák, and Jana Galambošová. "MicroRNA-based markers as a tool to monitor the barley (Hordeum vulgare L.) response to soil compaction." Acta fytotechnica et zootechnica 23, no. 3 (2020): 139–46. http://dx.doi.org/10.15414/afz.2020.23.03.139-146.

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Plants are often exposed to adverse environmental conditions that can significantly interfere with their genomic response. Soil compaction induced by heavy field machinery represents a major problem for crop production mainly due to restricted root growth and penetration into soil and therefore reduced water and nutrient uptake by the plants. Tested hypotheses were to declare whether the plant‘s genome responds to soil compaction and whether the microRNA-based markers are suitable to determine this response. A long term field scale experiment was established in 2009 where different levels of s

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Bortolotti, Daria, Irene Soffritti, Maria D’Accolti, et al. "HHV-6A Infection of Endometrial Epithelial Cells Affects miRNA Expression and Trophoblast Cell Attachment." Reproductive Sciences 27, no. 3 (2020): 779–86. http://dx.doi.org/10.1007/s43032-019-00102-8.

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AbstractWe recently reported that human herpesvirus 6 (HHV-6) infection is frequently present in endometrial tissue of women with unexplained infertility, and that virus infection induces a profound remodulation of miRNA expression in human cells of different origin. Since specific miRNA patterns have been associated with specific pregnancy outcomes, we aimed to analyze the impact of HHV-6A infection on miRNAs expression and trophoblast receptivity in human endometrial cells. To this purpose, a human endometrial cell line (HEC-1A) was infected with HHV-6A and analyzed for alterations in the ex

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Guo, Xiaorong, Junfeng Niu, and Xiaoyan Cao. "Heterologous Expression of Salvia miltiorrhiza MicroRNA408 Enhances Tolerance to Salt Stress in Nicotiana benthamiana." International Journal of Molecular Sciences 19, no. 12 (2018): 3985. http://dx.doi.org/10.3390/ijms19123985.

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MicroRNAs (miRNAs) are a class of endogenous small RNAs that regulate the expression of target genes post-transcriptionally; they are known to play major roles in development and responses to abiotic stress. MicroRNA408 (miR408) is a conserved small RNA in plants; it was reported that miR408 genes were involved in abiotic stress in Arabidopsis. However, miR408 in Salvia miltiorrhiza has been rarely investigated. In this study, we cloned Sm-MIR408, the miR408 precursor sequence, and its promoter sequence from S. miltiorrhiza and the role in tolerance to salt stress is described. The effects of

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Gao, Yu, Baohua Feng, Caixia Gao, et al. "The Evolution and Functional Roles of miR408 and Its Targets in Plants." International Journal of Molecular Sciences 23, no. 1 (2022): 530. http://dx.doi.org/10.3390/ijms23010530.

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MicroRNA408 (miR408) is an ancient and highly conserved miRNA, which is involved in the regulation of plant growth, development and stress response. However, previous research results on the evolution and functional roles of miR408 and its targets are relatively scattered, and there is a lack of a systematic comparison and comprehensive summary of the detailed evolutionary pathways and regulatory mechanisms of miR408 and its targets in plants. Here, we analyzed the evolutionary pathway of miR408 in plants, and summarized the functions of miR408 and its targets in regulating plant growth and de

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Szczygieł-Sommer and Gaj. "The miR396–GRF Regulatory Module Controls the Embryogenic Response in Arabidopsis via an Auxin-Related Pathway." International Journal of Molecular Sciences 20, no. 20 (2019): 5221. http://dx.doi.org/10.3390/ijms20205221.

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In plants, microRNAs have been indicated to control various developmental processes, including somatic embryogenesis (SE), which is triggered in the in vitro cultured somatic cells of plants. Although a transcriptomic analysis has indicated that numerous MIRNAs are differentially expressed in the SE of different plants, the role of specific miRNAs in the embryogenic reprogramming of the somatic cell transcriptome is still poorly understood. In this study, we focused on performing a functional analysis of miR396 in SE given that the transcripts of MIR396 genes and the mature molecules of miR396

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Kong, Demao, and Xia Wang. "miR126-Mediated Signal Transducer and Activator of Transcription 3 Signaling Pathway Regulates the Malignant Biological Behavior of Pancreatic Cancer Cells." Journal of Biomaterials and Tissue Engineering 10, no. 8 (2020): 1199–205. http://dx.doi.org/10.1166/jbt.2020.2401.

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Background and purpose: As a type of non-coding genetic material widely existing in eukaryotes, a growing amount of research have confirmed that it have close connection with the occurrence and progression of various malignancies. MicroRNA126 is increased in non-small-cell lung cancer, liver cancer and gastric carcinoma. The up-regulation of miR126 in cervical cancer is closely associated with the clinical staging, histological grade, depth of invasion and early metastasis of the tumor, and it is also of great value in predicting the survival prognosis of the tumor. However, there is little kn

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Zhao, Xian, Yanli Wang, Rong Deng, et al. "miR186 suppresses prostate cancer progression by targeting Twist1." Oncotarget 7, no. 22 (2016): 33136–51. http://dx.doi.org/10.18632/oncotarget.8887.

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Pegler, Joseph L., Duc Quan Nguyen, Jackson M. J. Oultram, Christopher P. L. Grof, and Andrew L. Eamens. "Molecular Manipulation of the MiR396/GRF Expression Module Alters the Salt Stress Response of Arabidopsis thaliana." Agronomy 11, no. 9 (2021): 1751. http://dx.doi.org/10.3390/agronomy11091751.

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We previously demonstrated that microRNA396 (miR396) abundance is altered in 15-day-old Arabidopsis thaliana (Arabidopsis) whole seedlings following their exposure to a 7-day salt stress treatment regime. We, therefore, used a molecular modification approach to generate two new Arabidopsis transformant populations with reduced (MIM396 plants) and elevated (MIR396 plants) miR396 abundance. The exposure of 8-day-old wild-type Arabidopsis whole seedlings and a representative plant line of the MIM396 and MIR396 transformant populations to a 7-day salt stress treatment regime revealed unique phenot

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Jin, Hong-Yi, Xin-Guang Qiu, and Bo Yang. "The MicroRNA3686 Inhibits the Proliferation of Pancreas Carcinoma Cell Line by Targeting the Polo-Like Kinase 1." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/954870.

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The Polo-like kinase 1 (PLK1) is one member of the so-called Polo-like kinase family which plays an important role in tumorigenesis. By analyzing the potential complementary microRNA (miRNA) targeting sequence of PLK1, we identified that miRNA-3686 (hereby and thereafter mir3696) could be the potential regulator for PLK1. Real-time PCR demonstrated that the mir3686 has a relatively higher expression in the immortalized pancreas cell HPDE6C7 than pancreas carcinoma derived cell line PANC1. The upregulation of mir3686 in HPDE6C7 cell corresponded with the low expression of PLK1 as well. Both luc

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Li, Hongshun, Yiwei Luo, Bi Ma, et al. "Hierarchical Action of Mulberry miR156 in the Vegetative Phase Transition." International Journal of Molecular Sciences 22, no. 11 (2021): 5550. http://dx.doi.org/10.3390/ijms22115550.

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The vegetative phase transition is a prerequisite for flowering in angiosperm plants. Mulberry miR156 has been confirmed to be a crucial factor in the vegetative phase transition in Arabidopsis thaliana. The over-expression of miR156 in transgenic Populus × canadensis dramatically prolongs the juvenile phase. Here, we find that the expression of mno-miR156 decreases with age in all tissues in mulberry, which led us to study the hierarchical action of miR156 in mulberry. Utilizing degradome sequencing and dual-luciferase reporter assays, nine MnSPLs were shown to be directly regulated by miR156

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Li, Meng, Ting Chen, Ran Wang та ін. "Plant MIR156 regulates intestinal growth in mammals by targeting the Wnt/β-catenin pathway". American Journal of Physiology-Cell Physiology 317, № 3 (2019): C434—C448. http://dx.doi.org/10.1152/ajpcell.00030.2019.

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MicroRNAs (miRNAs) are important negative regulators of genes involved in physiological and pathological processes in plants and animals. Recent studies have shown that miRNAs might regulate gene expression among different species in a cross-kingdom manner. However, the specific roles of plant miRNAs in animals remain poorly understood and somewhat. Herein, we found that plant MIR156 regulates proliferation of intestinal cells both in vitro and in vivo. Continuous administration of a high plant miRNA diet or synthetic MIR156 elevated MIR156 levels and inhibited the Wnt/β-catenin signaling path

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Xie, Qi, Xufeng Wang, Juan He, et al. "Distinct Evolutionary Profiles and Functions of microRNA156 and microRNA529 in Land Plants." International Journal of Molecular Sciences 22, no. 20 (2021): 11100. http://dx.doi.org/10.3390/ijms222011100.

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MicroRNA156 (miR156) and miR529 have high sequence similarity and recognize overlapping sites in the same target genes, SQUAMOSA promoter binding protein-like (SPL or SBP box) genes, making it difficult to accurately distinguish their roles in regulatory networks that affect numerous biological functions. Here, we collected data about miR156 and miR529 family members from representative land plants and performed sequence comparisons, phylogenetic analysis, small RNA sequencing, and parallel analysis of RNA ends (PARE) analysis to dissect their evolutionary and functional differences. Although

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Pegler, Joseph L., Duc Quan Nguyen, Christopher P. L. Grof, and Andrew L. Eamens. "Profiling of the Salt Stress Responsive MicroRNA Landscape of C4 Genetic Model Species Setaria viridis (L.) Beauv." Agronomy 10, no. 6 (2020): 837. http://dx.doi.org/10.3390/agronomy10060837.

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Setaria viridis has recently emerged as an ideal model species to genetically characterize the C4 monocotyledonous grasses via a molecular modification approach. Soil salinization has become a compelling agricultural problem globally with salinity adversely impacting the yield potential of many of the major cereals. Small regulatory molecules of RNA, termed microRNAs (miRNAs), were originally demonstrated crucial for developmental gene expression regulation in plants, however, miRNAs have since been shown to additionally command a central regulatory role in abiotic stress adaptation. Therefore

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Liu, Junying, Huiyan Fan, Ying Wang, et al. "Genome-Wide microRNA Profiling Using Oligonucleotide Microarray Reveals Regulatory Networks of microRNAs in Nicotiana benthamiana During Beet Necrotic Yellow Vein Virus Infection." Viruses 12, no. 3 (2020): 310. http://dx.doi.org/10.3390/v12030310.

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Beet necrotic yellow vein virus (BNYVV) infections induce stunting and leaf curling, as well as root and floral developmental defects and leaf senescence in Nicotiana benthamiana. A microarray analysis with probes capable of detecting 1596 candidate microRNAs (miRNAs) was conducted to investigate differentially expressed miRNAs and their targets upon BNYVV infection of N. benthamiana plants. Eight species-specific miRNAs of N. benthamiana were identified. Comprehensive characterization of the N. benthamiana microRNA profile in response to the BNYVV infection revealed that 129 miRNAs were alter

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