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Journal articles on the topic 'Mini-pig model'

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Author: Grafiati

Published: 10 December 2022

Last updated: 29 January 2023

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1

Ning, Xiaoyu, Kai Yang, Wei Shi, and Chenjie Xu. "Comparison of hypertrophic scarring on a red Duroc pig and a Guangxi Mini Bama pig." Scars, Burns & Healing 6 (January 2020): 205951312093090. http://dx.doi.org/10.1177/2059513120930903.

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Pigs are the most promising models for the study of wound healing and hypertrophic scarring because they are anatomically and physiologically similar to human beings. The Red Duroc pig and Mini Bama pig are two swine models that have attracted a lot of attention. The aim of the present study was to examine and compare the scarring process in a red Duroc pig and a Mini Bama pig, providing knowledge for researchers and clinicians to enable them to choose the most suitable pig model for studies.

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2

Lee, S. L., E. J. Kang, B. G. Jeon, J. K. Park, S. H. Hyun, Y. K. Joo, H. W. Sung, E. S. Lee, and G. J. Rho. "41 PRODUCTION OF CLONED MINIATURE PIGS USING BONE MARROW MESENCHYMAL STEM CELLS." Reproduction, Fertility and Development 21, no. 1 (2009): 120. http://dx.doi.org/10.1071/rdv21n1ab41.

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The cloning of miniature pigs (Mini-pig) are considered to advance in genetic engineering technology and xenotransplantation. A few researches have recently been reported successfully produce cloned Mini-pigs using somatic cells, however its efficiency is still low. The present study was aimed to successfully produce cloned Mini-pigs derived from bone marrow mesenchymal stem cells (MSCs) by NT, and compared the developmental ability of cloned Mini-pigs between fetal fibroblast (FF) and differentiated MSCs. For the production of the cloned Mini-pig derived from MSCs, MSCs were isolated from a 1 month old of female Mini-pigs (T-type, PWG Micro-pig®, PWG Genetics Korea, Ltd.). MSCs were differentiated into osteocytes, adipocytes, and chondrocytes under controlled conditions and characterized by cell surface antigen profile using specific markers. These differentiated or undifferentiated MSCs, FFs of Mini-pig were transferred into enucleated oocytes of domestic pigs, and 2-cell stage of 100 NT embryos were surgical transferred to the synchronized recipients. Statistical analysis was performed using one-way ANOVA, t-test, Duncan’s and Tukey’s multiple comparisons test by SPSS (SPSS, Inc., Chicago, IL, USA). The developmental potential of NT embryos derived from MSCs (differentiated and undifferentiated), the rates of blastocyst formation was significantly (P < 0.05) higher than NT embryos derived from FFs, however the NT embryos derived from three different types of differentiated MSCs were significantly (P < 0.05) lower than undifferentiated MSCs. In addition, total cell numbers in NT blastocysts derived from MSCs were significantly (P < 0.05) higher than NT blastocysts derived from FFs, but it did not significantly (P < 0.05) differ between differentiated or undifferentiated MSCs. NT embryos derived from MSCs were transferred to 5 domestic pig recipients, and 5 cloned Mini-pigs were obtained from 2 recipients (one stillbirth and 4 viable offspring). All of them were confirmed by the microsatellite analysis (8 markers) of the genomes of cloned offspring, donor MSCs and recipients. Physical and histological studies are in the process for the characterization of a cloned Mini-pig derived from MSCs as animal model. The results demonstrated that, in vitro developmental ability of NT embryos derived from undifferentiated MSCs were a higher than those from differentiated MSCs or FFs. Moreover, multipotent MSC might have a potential for the production of viable cloned Mini-pigs. Therefore, MSCs as a nuclear donor might a key to improving the production of cloned Mini-pig as animal model for xenotransplantation. This work was supported by Grant No. 20070301034040 from Bio-organ, Republic of Korea.

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3

Jo, Hyunwoong, Sang Chul Lee, and Beob Gyun Kim. "Estimation of growth model parameters for novel mini-pig breeds." Animal Industry and Technology 8, no. 2 (December 2021): 95–100. http://dx.doi.org/10.5187/ait.2021.8.2.95.

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4

Park, Dan Bi, Lila Kim, Jeong Ho Hwang, Kyung-Tai Kim, Ji Eun Park, Jong-Soon Choi, and Hyun Joo An. "Temporal quantitative profiling of sialyllactoses and sialic acids after oral administration of sialyllactose to mini-pigs with osteoarthritis." RSC Advances 13, no. 2 (2023): 1115–24. http://dx.doi.org/10.1039/d2ra05912f.

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In this work, we demonstrate the bioavailability of dietary sialyllactose by concentration–time profiles in an osteoarthritis mini-pig model and suggest a potential therapeutic effect of sialyllactose on osteoarthritis.

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5

Behrends, Dominique, Leticia Khendek, Chan Gao, Nadia Zayed, Janet Henderson, and Paul Martineau. "Characterization of a Pre-Clinical Mini-Pig Model of Scaphoid Non-Union." Journal of Functional Biomaterials 6, no. 2 (June 16, 2015): 407–21. http://dx.doi.org/10.3390/jfb6020407.

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6

Cagnone, G., T. S. Tsai, K. Srirattana, F. Rossello, D. R. Powell, G. Rohrer, L. Cree, I. A. Trounce, and J. C. St. John. "Segregation of Naturally Occurring Mitochondrial DNA Variants in a Mini-Pig Model." Genetics 202, no. 3 (January 27, 2016): 931–44. http://dx.doi.org/10.1534/genetics.115.181321.

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7

Demoner Ramos, Umberto, Barbara Masalskas, and Arthur Novaes Jr. "Induced periimplantitis in a novel mini‐pig model‐ description and defect characterization." Clinical Oral Implants Research 30, S19 (September 2019): 67. http://dx.doi.org/10.1111/clr.29_13509.

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8

Lindsay, CD, and P. Rice. "Changes in connective tissue macromolecular components of Yucatan mini-pig skin following application of sulphur mustard vapour." Human & Experimental Toxicology 14, no. 4 (April 1995): 341–48. http://dx.doi.org/10.1177/096032719501400404.

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1 The aim of this study was to determine the nature of the macromolecular alterations in Yucatan mini-pig skin which occur following application of sulphur mustard vapour, with particular reference to laminin and type IV collagen. 2 The immunostaining of transfer blots from skin extracts run on SDS-PAGE gels revealed no evidence of cross-link ing of type IV collagen or laminin. Laminin was, however, found to be partially degraded as determined by the reso lution of 132 and 143 kDa fragments, possibly by the acti vation of proteases, following the application of sulphur mustard to pig skin. Type IV collagen was not subject to this form of degradation in the skin samples exposed to sulphur mustard. 3 Yucatan mini-pig skin was found to develop microblis ters after exposure to sulphur mustard vapour. The immunohistochemical studies of sulphur mustard exposed skin revealed that separation of the epidermis from the dermis was found to occur within the lamina lucida of the subepidermal basement membrane, supporting the con tention that cleavage of laminin networks occurs following mustard challenge. Immunohistochemical staining with anti-type IV collagen antibodies was restricted to the floor of the micro-blister lesions. 4 The results suggest that laminin may be a target for pro tease activation at the dermo-epidermal junction. This may account for the tendency of certain skin models to develop sulphur mustard-induced blistering. The Yucatan mini-pig may be valuable as a model to determine the effi cacy of prophylactic and therapeutic regimes.

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Lowe, Jennifer, Rebecca Krisher, and Michael Sturek. "CHARACTERIZING THE OSSABAW MINI-PIG AS AN ANIMAL MODEL FOR POLYCYSTIC OVARY SYNDROME." Biology of Reproduction 77, Suppl_1 (July 1, 2007): 210–11. http://dx.doi.org/10.1093/biolreprod/77.s1.210b.

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10

Niu, Miaomiao, Yuqiong Zhao, Lei Xiang, Yunxiao Jia, Jifang Yuan, Xin Dai, and Hua Chen. "16S rRNA gene sequencing analysis of gut microbiome in a mini‐pig diabetes model." Animal Models and Experimental Medicine 5, no. 1 (February 2022): 81–88. http://dx.doi.org/10.1002/ame2.12202.

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11

Susin, Cristiano, Tiago Fiorini, Jaebum Lee, Rubens Moreno de Freitas, Hsien-Chung Chiu, Hari S. Prasad, Amanda N. Buxton, and Ulf M. E. Wikesjö. "Sinus augmentation using a mini-pig model: Effect of ceramic and allogeneic bone biomaterials." Journal of Clinical Periodontology 44, no. 10 (August 30, 2017): 1059–66. http://dx.doi.org/10.1111/jcpe.12766.

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12

Frey, P., N. Lutz, and A. L. Leuba. "Augmentation Cystoplasty Using Pedicled and De-epithelialized Gastric Patches in the Mini-Pig Model." Journal of Urology 156, no. 2S (August 1996): 608–13. http://dx.doi.org/10.1016/s0022-5347(01)65762-8.

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13

Lutz, N., and P. Frey. "Enterocystoplasty Using Modified Pedicled, Detubularized, De-epithelialized Sigmoid Patches in the Mini-pig Model." Journal of Urology 154, no. 2 (August 1995): 893–98. http://dx.doi.org/10.1016/s0022-5347(01)67197-0.

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14

Mei, Jin, ZhiXun Yin, Ji Zhang, Koonhei W. Lui, Siwang Hu, Zhou Peng, Shixin Chen, and Maolin Tang. "A mini pig model for visualization of perforator flap by using angiography and MIMICS." Surgical and Radiologic Anatomy 32, no. 5 (November 14, 2009): 477–84. http://dx.doi.org/10.1007/s00276-009-0588-6.

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15

MOY, LAWRENCE S., SHERI PEACE, and RONALD L. MOY. "Comparison of the Effect of Various Chemical Peeling Agents in a Mini-Pig Model." Dermatologic Surgery 22, no. 5 (May 1996): 429–32. http://dx.doi.org/10.1111/j.1524-4725.1996.tb00342.x.

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16

Lopez, David, Jonathan A. Pan, Peter M. Pollak, Samantha Clarke, Christopher M. Kramer, Mark Yeager, and Michael Salerno. "Multiparametric CMR imaging of infarct remodeling in a percutaneous reperfused Yucatan mini-pig model." NMR in Biomedicine 30, no. 5 (February 6, 2017): e3693. http://dx.doi.org/10.1002/nbm.3693.

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17

Rovetta, Alberto, Remo Sala, Xia Wen, Francesca Cosmi, Arianna Togno, and Santo Milanesi. "Telerobotic surgery project for laparoscopy." Robotica 13, no. 4 (July 1995): 397–400. http://dx.doi.org/10.1017/s0263574700018828.

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SummaryThis paper deals with the first transatlantic experiment of robotic telesurgery. A robot in Milan (Italy) performed an operation on a model of a pig, and the surgeon controller was in JPL, Pasadena (USA). By means of two communication satellites and of an optical fibre network, the robot performed a biopsy and a preliminary cut for a laparoscopic mini-invasive surgery operation.

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18

He, Jin, Qiuyan Li, Suyun Fang, Ying Guo, Tongxin Liu, Jianhua Ye, Zhengquan Yu, et al. "PKD1 Mono-Allelic Knockout Is Sufficient to Trigger Renal Cystogenesis in a Mini-Pig Model." International Journal of Biological Sciences 11, no. 4 (2015): 361–69. http://dx.doi.org/10.7150/ijbs.10858.

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19

Schlegel, Franziska, Marco Appler, Michelle Halling, Francis Edwin Smit, Friedrich-Wilhelm Mohr, Stefan Dhein, and Pascal Maria Dohmen. "Reprogramming Bone Marrow Stem Cells to Functional Endothelial Cells in a Mini Pig Animal Model." Medical Science Monitor Basic Research 23 (August 17, 2017): 285–94. http://dx.doi.org/10.12659/msmbr.905081.

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20

Gregory, Peter Colin, Katrin Hoffmann, Josef Kamphues, and Anne Möeler. "The Pancreatic Duct Ligated (Mini)pig as a Model for Pancreatic Exocrine Insufficiency in Man." Pancreas 45, no. 9 (October 2016): 1213–26. http://dx.doi.org/10.1097/mpa.0000000000000674.

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21

Leang, Ronika S., Lisa J. Kloft, Brad Gray, Arlene E. Gwon, and Ling C. Huang. "Preclinical Safety Evaluation of Ophthalmic Viscosurgical Devices in Rabbits and a Novel Mini-Pig Model." Ophthalmology and Therapy 8, no. 1 (February 18, 2019): 101–14. http://dx.doi.org/10.1007/s40123-019-0167-9.

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22

Aragoneses, Javier, Ana Suárez, Cinthia Rodríguez, and Juan Manuel Aragoneses. "Histomorphometric Comparison between Two Types of Acellular Dermal Matrix Grafts: A Mini Pig Animal Model Study." International Journal of Environmental Research and Public Health 18, no. 8 (April 7, 2021): 3881. http://dx.doi.org/10.3390/ijerph18083881.

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Acellular dermal matrix grafts (ADMG) have been used as soft tissue graft substitutes for autografts in periodontal plastic surgical procedures. They have benefits like avoiding a second surgical site and patient morbidity that have been associated with autografts, but there is limited evidence available on their tissue response and wound healing process. This histomorphometric animal model study was carried out in mini pigs and it aimed to compare the two types of ADMG materials of porcine derivative with a control group through observation of parameters like epithelial and Keratinized layer thickness, angiogenesis, cellularity, matrix resorption, and inflammatory infiltrate. The surgical technique involved punctures on the edentulous areas stripping the epithelial tissue and exposing the underlying connective tissue, placement of the ADMGs in the appropriate control and test sites. Following this, gingival biopsies were procured at three different time intervals of 15, 45, and 90 days. There were significant differences in epithelial and Keratinized layer thickness among the three groups. This study concluded that there was no clear consensus on which graft material was superior but it gave an insight into the tissue response and wound healing process associated with the graft materials.

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Shen, Po-Chih, Cheng-Chang Lu, Shih-Hsiang Chou, Zi-Miao Liu, Shu-Jem Su, and Yin-Chun Tien. "Zonal-Layered Chondrocyte Sheets for Repairment of Full-Thickness Articular Cartilage Defect: A Mini-Pig Model." Biomedicines 9, no. 12 (November 30, 2021): 1806. http://dx.doi.org/10.3390/biomedicines9121806.

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The cell sheet technique is a promising approach for tissue engineering, and the present study is aimed to determine a better configuration of cell sheets for cartilage repair. For stratified chondrocyte sheets (S-CS), articular chondrocytes isolated from superficial, middle, and deep zones were stacked accordingly. Heterogeneous chondrocyte sheets (H-CS) were obtained by mixing zonal chondrocytes. The expressions of chondrocytes, cytokine markers, and glycosaminoglycan (GAG) production were assessed in an in vitro assay. The curative effect was investigated in an in vivo porcine osteochondral defect model. The S-CS showed a higher cell viability, proliferation rate, expression of chondrogenic markers, secretion of tissue inhibitor of metalloproteinase, and GAG production level than the H-CS group. The expressions of ECM destruction enzyme and proinflammatory cytokines were lower in the S-CS group. In the mini-pigs articular cartilage defect model, the S-CS group had a higher International Cartilage Repair Society (ICRS) macroscopic score and displayed a zonal structure that more closely resembled the native cartilage than those implanted with the H-CS. Our study demonstrated that the application of the S-CS increased the hyaline cartilage formation and improved the surgical outcome of chondrocyte implication, offering a better tissue engineering strategy for treating articular cartilage defects.

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Chien, Shih-Kang, Shui-Sang Hsue, Chih-Shing Lin, Tzong-Fu Kuo, Duen-Jeng Wang, Jen-Chang Yang, and Sheng-Yang Lee. "Influence of Thread Design on Dental Implant Osseointegration Assayed Using the Lan-Yu Mini-Pig Model." Journal of Medical and Biological Engineering 37, no. 5 (June 17, 2017): 627–38. http://dx.doi.org/10.1007/s40846-017-0240-6.

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25

Rodgers, GP, AE Raizner, SC Woolbert, K. Wright, J. Guyton, GS Roubin, K. Robinson, D. Cromeens, LC Stephens, and ST Minor. "A superior animal model for human coronary artery restenosis after PTCA: The stented atherosclerotic mini-pig." Journal of the American College of Cardiology 17, no. 6 (May 1991): 196. http://dx.doi.org/10.1016/0735-1097(91)90962-9.

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Petinati, Nataliya, Irina Shipounova, Natalia Sats, Alena Dorofeeva, Alexandra Sadovskaya, Nikolay Kapranov, Yulia Tkachuk, et al. "Multipotent Mesenchymal Stromal Cells from Porcine Bone Marrow, Implanted under the Kidney Capsule, form an Ectopic Focus Containing Bone, Hematopoietic Stromal Microenvironment, and Muscles." Cells 12, no. 2 (January 10, 2023): 268. http://dx.doi.org/10.3390/cells12020268.

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Multipotent mesenchymal stromal cells (MSCs) are an object of intense investigation due to their therapeutic potential. MSCs have been well studied in vitro, while their fate after implantation in vivo has been poorly analyzed. We studied the properties of MSCs from the bone marrow (BM-MSC) before and after implantation under the renal capsule using a mini pig model. Autologous BM-MSCs were implanted under the kidney capsule. After 2.5 months, ectopic foci containing bones, foci of ectopic hematopoiesis, bone marrow stromal cells and muscle cells formed. Small pieces of the implant were cultivated as a whole. The cells that migrated out from these implants were cultured, cloned, analyzed and were proven to meet the most of criteria for MSCs, therefore, they are designated as MSCs from the implant—IM-MSCs. The IM-MSC population demonstrated high proliferative potential, similar to BM-MSCs. IM-MSC clones did not respond to adipogenic differentiation inductors: 33% of clones did not differentiate, and 67% differentiated toward an osteogenic lineage. The BM-MSCs revealed functional heterogeneity after implantation under the renal capsule. The BM-MSC population consists of mesenchymal precursor cells of various degrees of differentiation, including stem cells. These newly discovered properties of mini pig BM-MSCs reveal new possibilities in terms of their manipulation.

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Kim, Joongsun, Sunhoo Park, Byung-Suk Jeon, Won-Seok Jang, Sun-Joo Lee, Yeonghoon Son, Kyung-Jin Rhim, Soong In Lee, and Seung-Sook Lee. "Therapeutic effect of topical application of curcumin during treatment of radiation burns in a mini-pig model." Journal of Veterinary Science 17, no. 4 (2016): 435. http://dx.doi.org/10.4142/jvs.2016.17.4.435.

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28

Wiesenack, C., L. Schellenberg, C. Skrabal, S. Alban, J. G. Preuner, and M. Kaiser. "Dalteparin as an alternative anticoagulant for cardiopulmonary bypass: dose finding study in a Yucatan mini pig model." European Journal of Anaesthesiology 19, Supplement 27 (2002): 14. http://dx.doi.org/10.1097/00003643-200219271-00041.

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29

Fisher, Matthew B., Nicole S. Belkin, Andrew H. Milby, Elizabeth A. Henning, Nicole Söegaard, Minwook Kim, Christian Pfeifer, et al. "Effects of Mesenchymal Stem Cell and Growth Factor Delivery on Cartilage Repair in a Mini-Pig Model." CARTILAGE 7, no. 2 (December 28, 2015): 174–84. http://dx.doi.org/10.1177/1947603515623030.

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30

Otsuki, Shuhei, Kosuke Nakagawa, Tomohiko Murakami, Shunsuke Sezaki, Hideki Sato, Masakazu Suzuki, Nobuhiro Okuno, Hitoshi Wakama, Kunihiro Kaihatsu, and Masashi Neo. "Evaluation of Meniscal Regeneration in a Mini Pig Model Treated With a Novel Polyglycolic Acid Meniscal Scaffold." American Journal of Sports Medicine 47, no. 8 (June 7, 2019): 1804–15. http://dx.doi.org/10.1177/0363546519850578.

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Background: Meniscal injury is a severe impediment to movement and results in accelerated deterioration of the knee joint. Purpose: To evaluate the effect of a novel meniscal scaffold prepared from polyglycolic acid coated with polylactic acid/caprolactone on the treatment of meniscal injury in a mini pig model. Study Design: Controlled laboratory study. Methods: The model was established with a 10-mm resection at the anterior medial meniscus on both knee joints. A scaffold was implanted in the right knee joint. The meniscal scaffold was inserted and sutured next to the native meniscus. The histological analysis was performed to determine meniscal regeneration with safranin O staining, cell proliferation with PCNA, inflammation with TNF, and collagen structure and production with picrosirius red and immunofluorescence. Cartilage degeneration was evaluated with Safranin O. Meniscal regeneration and joint fluid were evaluated with magnetic resonance imaging. Results: Although compressive stress and elastic modulus were significantly lower in the scaffold than in the native porcine menisci, ultimate tensile stress was similar. Implanted scaffolds were covered with tissue beginning at 4 weeks, with increased migration of proliferating cells to the implant area at 4 and 8 weeks. Scaffolds were absorbed with freshly produced collagen at 24 weeks. Cartilage degeneration was significantly lower in the meniscus-implanted group than in the meniscectomy group. Magnetic resonance imaging results did not show severe accumulation of joint fluids, suggesting negligible inflammation. Density of the implanted menisci was comparable with that of the native menisci. Conclusion: Meniscal scaffold prepared from polyglycolic acid has therapeutic potential for meniscal regeneration. Clinical Relevance: This meniscal scaffold can improve biological knee reconstruction and prevent the increase of total knee arthroplasty.

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SCHEEPE, J., J. VANDENHOEK, K. JUNEMANN, and P. ALKEN. "A standardised mini pig model for in vivo investigations of anticholinergic effects on bladder function and salivation." Pharmacological Research 55, no. 5 (May 2007): 450–54. http://dx.doi.org/10.1016/j.phrs.2007.02.002.

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32

Rimondini, Lia, Giovan Battista Bruschi, Agostino Scipioni, Antonio Carrassi, Nicoló Nicoli-Aldini, Gianluca Giavaresi, Milena Fini, Carmen Mortellaro, and Roberto Giardino. "Tissue healing in implants immediately placed into postextraction sockets: A pilot study in a mini-pig model." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 100, no. 3 (September 2005): e43-e50. http://dx.doi.org/10.1016/j.tripleo.2005.05.058.

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33

Yamada, Yoshihisa, Shingo Minatoguchi, Shinya Baba, Sanae Shibata, Satoshi Takashima, Shohei Wakao, Hiroyuki Okura, Mari Dezawa, and Shinya Minatoguchi. "Human Muse cells reduce myocardial infarct size and improve cardiac function without causing arrythmias in a swine model of acute myocardial infarction." PLOS ONE 17, no. 3 (March 24, 2022): e0265347. http://dx.doi.org/10.1371/journal.pone.0265347.

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Background We recently reported that multilineage-differentiating stress enduring (Muse) cells intravenously administered after acute myocardial infarction (AMI), selectively engrafted to the infarct area, spontaneously differentiated into cardiomyocytes and vessels, reduced the infarct size, improved the left ventricular (LV) function and remodeling in rabbits. We aimed to clarify the efficiency of Muse cells in a larger animal AMI model of mini-pigs using a semi-clinical grade human Muse cell product. Method and result Mini-pigs underwent 30 min of coronary artery occlusion followed by 2 weeks of reperfusion. Semi-clinical grade human Muse cell product (1x107, Muse group, n = 5) or saline (Vehicle group, n = 7) were intravenously administered at 24 h after reperfusion. The infarct size, LV function and remodeling were evaluated by echocardiography. Arrhythmias were evaluated by an implantable loop recorder. The infarct size was significantly smaller in the Muse group (10.5±3.3%) than in the Vehicle group (21.0±2.0%). Both the LV ejection fraction and fractional shortening were significantly greater in the Muse group than in the Vehicle group. The LV end-systolic and end-diastolic dimensions were significantly smaller in the Muse group than in the Vehicle group. Human Muse cells homed into the infarct border area and expressed cardiac troponin I and vascular endothelial CD31. No arrhythmias and no blood test abnormality were observed. Conclusion Muse cell product might be promising for AMI therapy based on the efficiency and safety in a mini-pig AMI.

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Friedman, James M., Mackenzie L. Sennett, Marcelo B. Bonadio, Kerry O. Orji, Alexander L. Neuwirth, Niobra Keah, James L. Carey, et al. "Comparison of Fixation Techniques of 3D-Woven Poly(ϵ-Caprolactone) Scaffolds for Cartilage Repair in a Weightbearing Porcine Large Animal Model." CARTILAGE 9, no. 4 (April 11, 2017): 428–37. http://dx.doi.org/10.1177/1947603517700953.

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Objective To test different fixation methods of a 3-dimensionally woven poly(ϵ-caprolactone) (PCL) scaffold within chondral defects of a weightbearing large animal model. Methods Full thickness chondral defects were made in the femoral condyles of 15 adult male Yucatan mini-pigs. Two surgical approaches were compared including total arthrotomy (traditional) and a retinaculum-sparing, minimally invasive surgery (MIS) approach. Following microfracture (MFX), scaffolds were placed without fixation or were fixed with fibrin glue, suture, or subchondral anchor. Experimental endpoints were between 1 and 6 weeks. Micro–computed tomography and histology were used to assess samples. Results The MIS approach was superior as the traditional approach caused medial condyle cartilage wear. One of 13 (7.7%) of scaffolds without fixation, 4 of 11 (36.3%) fibrin scaffolds, 1 of 4 (25%) of sutured scaffolds, and 9 of 9 (100%) of anchor-fixed scaffolds remained in place. Histology demonstrated tissue filling with some overgrowth of PCL scaffolds. Conclusions Of the methods tested, the MIS approach coupled with subchondral anchor fixation provided the best scaffold retention in a mini-pig chondral defect model. This finding has implications for fixation strategies in future animal studies and potential future human use.

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35

Safiullov, Zufar, Andrei Izmailov, Mikhail Sokolov, Vage Markosyan, Grayr Kundakchan, Ravil Garifulin, Maksim Shmarov, Boris Naroditsky, Denis Logunov, and Rustem Islamov. "Autologous Genetically Enriched Leucoconcentrate in the Preventive and Acute Phases of Stroke Treatment in a Mini-Pig Model." Pharmaceutics 14, no. 10 (October 17, 2022): 2209. http://dx.doi.org/10.3390/pharmaceutics14102209.

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The natural limitations of regeneration in the CNS are major problems for the treatment of neurological disorders, including ischaemic brain strokes. Among the approaches being actively developed to inhibit post-ischaemic negative consequences is the delivery of therapeutic genes encoding neuroprotective molecules to the brain. Unfortunately, there are currently no proven and available medicines that contain recombinant human genes for the treatment of ischaemic cerebral stroke. Of particular interest is the development of treatments for patients at risk of ischaemic stroke. In the present study, we propose a proof of concept for the use of an autologous, genetically enriched leucoconcentrate temporally secreting recombinant vascular endothelial growth factor (VEGF), glial-cell-line-derived neurotrophic factor (GDNF) and the neural cell adhesion molecule (NCAM) for the treatment of stroke. In a mini-pig ischaemic stroke model, genetically enriched leucoconcentrate was infused 4 h after surgery (gene therapy in acute phase) or 2 days before stroke modelling (preventive gene therapy). On day 21, after the stroke modelling, the post-ischaemic brain recovery was examined by morphologic and immunofluorescence analysis. The benefits of treating a stroke with genetically enriched leucoconcentrate both for preventive purposes and in the acute phase were confirmed by an improved performance in behavioural tests, higher preservation of brain tissue and positive post-ischaemic brain remodelling in the peri-infarct area. These results suggest that the employment of autologous leucocytes enabling the temporary production of the recombinant therapeutic molecules to correct the pathological process in the CNS may be one of the breakthrough approaches in gene therapy.

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Xie, Li-Ting, Dan-Xia Xu, Guo Tian, Li-Yun Zhong, Qi-Yu Zhao, Qing-Hong Ke, and Tian-An Jiang. "Value of Two-Dimensional Shear Wave Elastography for Assessing Acute Liver Congestion in a Bama Mini-Pig Model." Digestive Diseases and Sciences 63, no. 7 (May 8, 2018): 1851–59. http://dx.doi.org/10.1007/s10620-018-5085-5.

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Okabe, Tomoyuki, Masami Katoh, Mayumi Kano, Risa Okazaki, Yoshiyuki Tanaka, Hiromu Toyoda, and Masayoshi Ueno. "Studies of the Various Chronic Kidney Failure Rat Models and Hemodialysis Mini-pig Model for the Evaluation of Anti-hyperphosphatemia Drugs." YAKUGAKU ZASSHI 139, no. 11 (November 1, 2019): 1435–48. http://dx.doi.org/10.1248/yakushi.19-00082.

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Martin, GP, BE Loveday, and C. Marriott. "The effect of bromhexine hydrochloride on the viscoelastic properties of mucus from the mini-pig." European Respiratory Journal 3, no. 4 (April 1, 1990): 392–96. http://dx.doi.org/10.1183/09031936.93.03040392.

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Mucus was collected daily from open-ended pouches established surgically in three mini-pigs. After a five day control period bromhexine hydrochloride (BHCl) was administered to each pig at dose levels of 0.5, 1.0 and 2.0 mg.kg-1 twice daily for five days. Each study period was followed by a five day washout period, when mucus was collected but no drug given. The viscoelastic properties of each mucus sample were determined using creep compliance analysis. BHCl was shown to reduce the residual shear viscosity (p less than 0.05) and increase the instantaneous shear compliance at all dose levels (p less than 0.005), despite the large inherent intra- and inter-animal variation in the rheological properties of the daily samples. No change was found in the wet weight of the mucus samples throughout any of the study periods. This experimental model would appear to provide a valuable in vivo method of assessing the mucoregulatory potential of administered compounds.

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Wang, Si-Yang, Chao-Yang Zhang, Guang-Yan Cai, and Xiang-Mei Chen. "Method used to establish a large animal model of drug-induced acute kidney injury." Experimental Biology and Medicine 246, no. 8 (January 19, 2021): 986–95. http://dx.doi.org/10.1177/1535370220981756.

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Acute kidney injury is a serious health hazard disease due to its complex etiology and lack of effective treatments, resulting in high medical costs and high mortality. At present, a large number of basic research studies on acute kidney injury have been carried out. However, acute kidney injury models established in rodents sometimes do not simulate the course of human disease well. Research in large animal models of acute kidney injury is relatively rare, and methods to build a mature model of acute kidney injury have failed. Because its kidney anatomy and morphology are very similar to those in humans, the mini pig is an ideal animal in which to model kidney disease. Nephrotoxic drug-induced acute kidney injury has a high incidence. In this study, we established models of acute kidney injury induced by two drugs (gentamicin and cisplatin). Finally, the model of cisplatin-induced acute kidney injury was developed successfully, but we found the model of gentamycin-induced acute kidney injury was not reproducible. Compared to other models, these models better represent acute kidney injury caused by antibiotics and chemotherapeutic drugs and provide a basis for the study of new treatments for acute kidney injury in a large animal model.

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Islamov, RustemR, AlbertA Rizvanov, FaridV Bashirov, MikhailE Sokolov, AndreiA Izmailov, FilipO Fadeev, VageA Markosyan, et al. "Gene-modified leucoconcentrate for personalized ex vivo gene therapy in a mini pig model of moderate spinal cord injury." Neural Regeneration Research 16, no. 2 (2021): 357. http://dx.doi.org/10.4103/1673-5374.290902.

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Susin, Cristiano, Jaebum Lee, Tiago Fiorini, Rubens Moreno Freitas, Hsien‐Chung Chiu, Hari S. Prasad, Amanda N. Buxton, and Ulf ME Wikesjö. "Sinus augmentation using rh BMP ‐2/ ACS in a mini‐pig model: Influence of an adjunctive ceramic bone biomaterial." Journal of Clinical Periodontology 45, no. 8 (June 19, 2018): 1005–13. http://dx.doi.org/10.1111/jcpe.12921.

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Ding, Jing, Jin He, Zhi-qiang Zhang, Zhen-kai Wu, and Fang-chun Jin. "Effect of Hemiepiphysiodesis on the Growth Plate: The Histopathological Changes and Mechanism Exploration of Recurrence in Mini Pig Model." BioMed Research International 2018 (December 30, 2018): 1–10. http://dx.doi.org/10.1155/2018/6348171.

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Purpose. Hemiepiphysiodesis has been widely used to correct angular deformity of long bone in immature patients. However, there is a limited knowledge about the biomechanical effect of this technique on the histopathological changes of the growth plate and the mechanism of recurrence of malformation after implant removal. We aimed to evaluate the biomechanical effect of hemiepiphysiodesis on the histopathological changes of the growth plate and the mechanism of recurrence of malformation after implant removal in Bama miniature pigs, and to explore the role of asymmetric stress during this procedure. Methods. Eight 3-month-old male Bama miniature pigs sustained surgeries on the bilateral medial hind leg proximal tibia as the intervention group (n=16), and four pigs sustained bilateral sham surgeries as the control (n=8). In the 18th week after surgeries, hardware was removed in the unilateral leg of each animal in the intervention group. In the 24th week of the study, all animals were euthanized. A total of 24 samples were obtained and stained with H&E, TUNEL, and immunohistochemistry. Sixteen samples in the intervention group were divided into two subgroups. The tibias without an implant were included in the implant removal group (IR group), while the tibias with an implant were included in the implant persist group (IP group). The proximal tibia specimens were divided into 3 equidistant parts from medial to lateral, named as area A, area B, and area C, respectively. The change of thickness of growth plates, chondral apoptosis index, and the expression of Caspase-3, Caspase-9, CHOP, and P65 were compared. Results. H&E staining showed the thickness of growth plate to be varied in different areas. In the IP group, the thickness of growth plate in areas A and B was statistically significantly thinner than that in area C (p<0.05). In the IR group, the thickness of growth plate in areas A and B was statistically significantly thicker than that in area C (p<0.05). TUNEL staining showed that the apoptosis rate increased significantly after hemiepiphysiodesis and declined after implant removal (p<0.05). Immunohistochemical staining suggested that the expression of Caspase-3, Caspase-9, P65, and CHOP protein was upregulated in the experimental group and downregulated after implant removal. Conclusion. The thickness parameter of the growth plate changes with asymmetric pressure. When the pressure is relieved, the recurrence of malformation is related to the thickening of the growth plate.

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Du, Wen-Hua, Wang Xiang, Dao-Cheng Liu, Lian-Yang Zhang, Tao Li, Shi-Jin Sun, and Hao Tan. "Usefulness of Speckle Tracking Imaging to Assess Myocardial Contractility in Intra-Abdominal Hypertension: Study in a Mini-Pig Model." Cell Biochemistry and Biophysics 64, no. 2 (June 15, 2012): 123–29. http://dx.doi.org/10.1007/s12013-012-9380-z.

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Hou, Lin, Jian Wang, Xinyue Li, Hu Wang, Guishu Liu, Bo Xu, Xingxing Mei, Xiuguo Hua, and Ji Wu. "Characteristics of Female Germline Stem Cells from Porcine Ovaries at Sexual Maturity." Cell Transplantation 27, no. 8 (July 11, 2018): 1195–202. http://dx.doi.org/10.1177/0963689718784878.

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Pigs share many anatomical and physiological features with humans, offering a unique and viable model for biomedical research. Although porcine female germline stem cells (FGSCs) were identified in the juvenile ovary, no reports described the isolation and purification of FGSCs from the pig at sexual maturity. Here, we isolated, purified, and cultured FGSCs from porcine ovaries at sexual maturity. Furthermore, we established and characterized the porcine FGSC (pFGSC) lines. In addition, we found that pFGSC lines could differentiate into oocytes when injection into tissue grafts, including human ovarian tissues. The results show that FGSCs exist in ovaries of Banna mini-pigs at juvenile and sexually maturity. These findings have implications in animal biotechnology applications and regeneration medicine.

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Liu, Yingying, Fengna Li, Lingyun He, Bie Tan, Jinping Deng, Xiangfeng Kong, Yinghui Li, Meimei Geng, Yulong Yin, and Guoyao Wu. "Dietary protein intake affects expression of genes for lipid metabolism in porcine skeletal muscle in a genotype-dependent manner." British Journal of Nutrition 113, no. 7 (March 16, 2015): 1069–77. http://dx.doi.org/10.1017/s0007114514004310.

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Skeletal muscle is a major site for the oxidation of fatty acids (FA) in mammals, including humans. Using a swine model, we tested the hypothesis that dietary protein intake regulates the expression of key genes for lipid metabolism in skeletal muscle. A total of ninety-six barrows (forty-eight pure-bred Bama mini-pigs (fatty genotype) and forty-eight Landrace pigs (lean genotype)) were fed from 5 weeks of age to market weight. Pigs of fatty or lean genotype were randomly assigned to one of two dietary treatments (low- or adequate-protein diet), with twenty-four individually fed pigs per treatment. Our data showed that dietary protein levels affected the expression of genes involved in the anabolism and catabolism of lipids in the longissimus dorsi and biceps femoris muscles in a genotype-dependent manner. Specifically, Bama mini-pigs had more intramuscular fat, SFA and MUFA, as well as elevated mRNA expression levels of lipogenic genes, compared with Landrace pigs. In contrast, Bama mini-pigs had lower mRNA expression levels of lipolytic genes than Landrace pigs fed an adequate-protein diet in the growing phase. These data are consistent with higher white-fat deposition in Bama mini-pigs than in Landrace pigs. In conclusion, adequate provision of dietary protein (amino acids) plays an important role in regulating the expression of key lipogenic genes, and the growth of white adipose tissue, in a genotype- and tissue-specific manner. These findings have important implications for developing novel dietary strategies in pig production.

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Kuzma, Benjamin A., Sharareh Senemar, Tannaz Ramezanli, Priyanka Ghosh, Sam G. Raney, and Grazia Stagni. "Evaluation of local bioavailability of metronidazole from topical formulations using dermal microdialysis: Preliminary study in a Yucatan mini-pig model." European Journal of Pharmaceutical Sciences 159 (April 2021): 105741. http://dx.doi.org/10.1016/j.ejps.2021.105741.

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Fisher, Matthew B., Nicole S. Belkin, Andrew H. Milby, Elizabeth A. Henning, Marc Bostrom, Minwook Kim, Christian Pfeifer, et al. "Cartilage Repair and Subchondral Bone Remodeling in Response to Focal Lesions in a Mini-Pig Model: Implications for Tissue Engineering." Tissue Engineering Part A 21, no. 3-4 (February 2015): 850–60. http://dx.doi.org/10.1089/ten.tea.2014.0384.

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Anzenbacherova, Eva, Jana Baranova, Roman Zuber, Alena Pechova, Pavel Anzenbacher, Pavel Soucek, and Jirina Martinkova. "Model Systems Based on Experimental Animals for Studies on Drug Metabolism in Man: (Mini)Pig Cytochromes P450 3A29 and 2E1." Basic Clinical Pharmacology Toxicology 96, no. 3 (March 2005): 244–45. http://dx.doi.org/10.1111/j.1742-7843.2005.pto960316.x.

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Nikovics, Krisztina, Halima Morin, Diane Riccobono, Abdelhafid Bendahmane, and Anne‐Laure Favier. "Hybridization‐chain‐reaction is a relevant method for in situ detection of M2d‐like macrophages in a mini‐pig model." FASEB Journal 34, no. 12 (October 20, 2020): 15675–86. http://dx.doi.org/10.1096/fj.202001496r.

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Hou, C., C. Lin, C. Wu, L. Tsung, M. Lin, Y. Chen, S. Chang, et al. "Cardiac function evaluation of bone marrow mesenchymal stromal cells intracoronary transplantation in acute myocardial infarction Lee-Sung mini-PIG model." Cytotherapy 22, no. 5 (May 2020): S75. http://dx.doi.org/10.1016/j.jcyt.2020.03.119.

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