Relevant bibliographies by topics / Mini-pig model

Academic literature on the topic 'Mini-pig model'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Mini-pig model"

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Ning, Xiaoyu, Kai Yang, Wei Shi, and Chenjie Xu. "Comparison of hypertrophic scarring on a red Duroc pig and a Guangxi Mini Bama pig." Scars, Burns & Healing 6 (January 2020): 205951312093090. http://dx.doi.org/10.1177/2059513120930903.

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Pigs are the most promising models for the study of wound healing and hypertrophic scarring because they are anatomically and physiologically similar to human beings. The Red Duroc pig and Mini Bama pig are two swine models that have attracted a lot of attention. The aim of the present study was to examine and compare the scarring process in a red Duroc pig and a Mini Bama pig, providing knowledge for researchers and clinicians to enable them to choose the most suitable pig model for studies.
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Lee, S. L., E. J. Kang, B. G. Jeon, J. K. Park, S. H. Hyun, Y. K. Joo, H. W. Sung, E. S. Lee, and G. J. Rho. "41 PRODUCTION OF CLONED MINIATURE PIGS USING BONE MARROW MESENCHYMAL STEM CELLS." Reproduction, Fertility and Development 21, no. 1 (2009): 120. http://dx.doi.org/10.1071/rdv21n1ab41.

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The cloning of miniature pigs (Mini-pig) are considered to advance in genetic engineering technology and xenotransplantation. A few researches have recently been reported successfully produce cloned Mini-pigs using somatic cells, however its efficiency is still low. The present study was aimed to successfully produce cloned Mini-pigs derived from bone marrow mesenchymal stem cells (MSCs) by NT, and compared the developmental ability of cloned Mini-pigs between fetal fibroblast (FF) and differentiated MSCs. For the production of the cloned Mini-pig derived from MSCs, MSCs were isolated from a 1 month old of female Mini-pigs (T-type, PWG Micro-pig®, PWG Genetics Korea, Ltd.). MSCs were differentiated into osteocytes, adipocytes, and chondrocytes under controlled conditions and characterized by cell surface antigen profile using specific markers. These differentiated or undifferentiated MSCs, FFs of Mini-pig were transferred into enucleated oocytes of domestic pigs, and 2-cell stage of 100 NT embryos were surgical transferred to the synchronized recipients. Statistical analysis was performed using one-way ANOVA, t-test, Duncan’s and Tukey’s multiple comparisons test by SPSS (SPSS, Inc., Chicago, IL, USA). The developmental potential of NT embryos derived from MSCs (differentiated and undifferentiated), the rates of blastocyst formation was significantly (P < 0.05) higher than NT embryos derived from FFs, however the NT embryos derived from three different types of differentiated MSCs were significantly (P < 0.05) lower than undifferentiated MSCs. In addition, total cell numbers in NT blastocysts derived from MSCs were significantly (P < 0.05) higher than NT blastocysts derived from FFs, but it did not significantly (P < 0.05) differ between differentiated or undifferentiated MSCs. NT embryos derived from MSCs were transferred to 5 domestic pig recipients, and 5 cloned Mini-pigs were obtained from 2 recipients (one stillbirth and 4 viable offspring). All of them were confirmed by the microsatellite analysis (8 markers) of the genomes of cloned offspring, donor MSCs and recipients. Physical and histological studies are in the process for the characterization of a cloned Mini-pig derived from MSCs as animal model. The results demonstrated that, in vitro developmental ability of NT embryos derived from undifferentiated MSCs were a higher than those from differentiated MSCs or FFs. Moreover, multipotent MSC might have a potential for the production of viable cloned Mini-pigs. Therefore, MSCs as a nuclear donor might a key to improving the production of cloned Mini-pig as animal model for xenotransplantation. This work was supported by Grant No. 20070301034040 from Bio-organ, Republic of Korea.
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Jo, Hyunwoong, Sang Chul Lee, and Beob Gyun Kim. "Estimation of growth model parameters for novel mini-pig breeds." Animal Industry and Technology 8, no. 2 (December 2021): 95–100. http://dx.doi.org/10.5187/ait.2021.8.2.95.

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Park, Dan Bi, Lila Kim, Jeong Ho Hwang, Kyung-Tai Kim, Ji Eun Park, Jong-Soon Choi, and Hyun Joo An. "Temporal quantitative profiling of sialyllactoses and sialic acids after oral administration of sialyllactose to mini-pigs with osteoarthritis." RSC Advances 13, no. 2 (2023): 1115–24. http://dx.doi.org/10.1039/d2ra05912f.

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In this work, we demonstrate the bioavailability of dietary sialyllactose by concentration–time profiles in an osteoarthritis mini-pig model and suggest a potential therapeutic effect of sialyllactose on osteoarthritis.
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Behrends, Dominique, Leticia Khendek, Chan Gao, Nadia Zayed, Janet Henderson, and Paul Martineau. "Characterization of a Pre-Clinical Mini-Pig Model of Scaphoid Non-Union." Journal of Functional Biomaterials 6, no. 2 (June 16, 2015): 407–21. http://dx.doi.org/10.3390/jfb6020407.

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Cagnone, G., T. S. Tsai, K. Srirattana, F. Rossello, D. R. Powell, G. Rohrer, L. Cree, I. A. Trounce, and J. C. St. John. "Segregation of Naturally Occurring Mitochondrial DNA Variants in a Mini-Pig Model." Genetics 202, no. 3 (January 27, 2016): 931–44. http://dx.doi.org/10.1534/genetics.115.181321.

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Demoner Ramos, Umberto, Barbara Masalskas, and Arthur Novaes Jr. "Induced periimplantitis in a novel mini‐pig model‐ description and defect characterization." Clinical Oral Implants Research 30, S19 (September 2019): 67. http://dx.doi.org/10.1111/clr.29_13509.

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Lindsay, CD, and P. Rice. "Changes in connective tissue macromolecular components of Yucatan mini-pig skin following application of sulphur mustard vapour." Human & Experimental Toxicology 14, no. 4 (April 1995): 341–48. http://dx.doi.org/10.1177/096032719501400404.

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1 The aim of this study was to determine the nature of the macromolecular alterations in Yucatan mini-pig skin which occur following application of sulphur mustard vapour, with particular reference to laminin and type IV collagen. 2 The immunostaining of transfer blots from skin extracts run on SDS-PAGE gels revealed no evidence of cross-link ing of type IV collagen or laminin. Laminin was, however, found to be partially degraded as determined by the reso lution of 132 and 143 kDa fragments, possibly by the acti vation of proteases, following the application of sulphur mustard to pig skin. Type IV collagen was not subject to this form of degradation in the skin samples exposed to sulphur mustard. 3 Yucatan mini-pig skin was found to develop microblis ters after exposure to sulphur mustard vapour. The immunohistochemical studies of sulphur mustard exposed skin revealed that separation of the epidermis from the dermis was found to occur within the lamina lucida of the subepidermal basement membrane, supporting the con tention that cleavage of laminin networks occurs following mustard challenge. Immunohistochemical staining with anti-type IV collagen antibodies was restricted to the floor of the micro-blister lesions. 4 The results suggest that laminin may be a target for pro tease activation at the dermo-epidermal junction. This may account for the tendency of certain skin models to develop sulphur mustard-induced blistering. The Yucatan mini-pig may be valuable as a model to determine the effi cacy of prophylactic and therapeutic regimes.
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Lowe, Jennifer, Rebecca Krisher, and Michael Sturek. "CHARACTERIZING THE OSSABAW MINI-PIG AS AN ANIMAL MODEL FOR POLYCYSTIC OVARY SYNDROME." Biology of Reproduction 77, Suppl_1 (July 1, 2007): 210–11. http://dx.doi.org/10.1093/biolreprod/77.s1.210b.

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Niu, Miaomiao, Yuqiong Zhao, Lei Xiang, Yunxiao Jia, Jifang Yuan, Xin Dai, and Hua Chen. "16S rRNA gene sequencing analysis of gut microbiome in a mini‐pig diabetes model." Animal Models and Experimental Medicine 5, no. 1 (February 2022): 81–88. http://dx.doi.org/10.1002/ame2.12202.

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Dissertations / Theses on the topic "Mini-pig model"

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Seifert, Adrian. "Histologische Analyse der Remodulierungsvorgänge eines biokompatiblen Kollagen-Meshs zur Therapie kongenitaler Bauchwanddefekte im Mini-Pig-Modell." kostenfrei, 2009. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-38489.

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Seifert, Adrian. "Histologische Analyse der Remodulierungsvorgänge eines biokompatiblen Kollagen-Meshs zur Therapie kongenitaler Bauchwanddefekte im Mini-Pig-Modell." Doctoral thesis, 2009. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-38489.

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Kongenitale Bauchwanddefekte (z.B. Gastroschisis, Omphalozele) sind seltene, aber dramatische Fehlbildungen der vorderen Bauchwand. Die Therapie besteht in der Bauchdeckenrekonstruktion. Methode der Wahl ist der Primärverschluss, der allerdings nur bei kleinen Defekten möglich ist. Ist die Masse der hernierten Organe hingegen zu groß, wird eine Bauchdeckenersatzplastik notwendig. In den vergangenen Jahren wurde hierfür vor allem ein Mesh aus PTFE (Gore-Tex®) verwendet. Um die mit der operativen Therapie verbundenen Komplikationen möglichst gering zu halten, stellt sich allerdings die Frage, inwieweit ein neues biokompatibles Material verwendet werden kann. Um dies zu klären, wurde Lyoplant®, als Vorstufe vor der klinischen Anwendung, in einer tierexperimentellen Studie auf seine Eignung zur Therapie von Gastroschisis und Omphalozele untersucht. Als Versuchstiere dienten 10 Göttinger Miniaturschweine (n=10), bei denen ein 10,0 x 8,0cm großer Defekt der ventralen Bauchwand mit einem Lyoplant®-Kollagen-Mesh verschlossen wurde. Die Miniaturschweine wurden regelmäßig untersucht und die Entwicklung einer Hernie ausgeschlossen. Nach jeweils 3, 6, 9 und 12 Monaten wurde der Grad der Adhäsionen laparoskopisch bestimmt. Das Implantat wurde im Anschluss zur Messung der Implantatdicke und histologischen Analyse entnommen. Alle Versuchstiere zeigten eine physiologische Wachstums- und Gewichtskurve. Bei keinem der Miniaturschweine kam es im Verlauf zu einer Hernienbildung oder Wundinfektion. Mit Lyoplant® entstanden nur minimale Adhäsionen zum Intestinum, die leicht mit einer laparoskopischen Fasszange zu lösen waren. In der histologischen Auswertung zeigte sich eine gute Vaskularisation und Zellimmigration. Die Immunantwort von Lyoplant® scheint eher der einer Remodulierung als der einer Abstoßungsreaktion zu entsprechen. Lyoplant® ist gut verträglich und zeigt eine gute Integration in das Nachbargewebe. Diese Ergebnisse erlauben die Schlussfolgerung, dass Lyoplant® zur Therapie kongenitaler Bauchwanddefekte geeignet ist
Congenital abdominal wall defects (e.g. Gastroschisis, Ompahlocele) are impressive and dramatic malformations. Common surgical therapy is to place the herniated viscera back into the abdomen and to close the fascia. Small defects can be closed directly by surgical treatment. In large defects, resorbable and nonresorbable artificial materials are necessary to close the fascia. ´ The aim of this study was to determine whether new biocompatible materials might be suitable for the treatment of abdominal wall defects. In order to prove this thesis an experimental animal-study using mini-pigs (n=10) was set up. A median laparotomy was performed and a full thickness defect was created by excising a 10,0 x 8,0 cm segment including fascia, muscles and peritoneum. These defects were then closed by implantation of a new biocompatible mesh (NBM, Lyoplant®). The mini pigs were examined regularly after the surgical procedure. Bodyweight was determined and the possible development of a hernia was monitored. After 3, 6, 9 and 12 months adhesions were evaluated laparoscopically, afterwards the abdomen was opened again and the abdominal wall was removed for histological examination. All animals showed physiologic growth and normal bodyweight curve. In none of the mini-pigs a hernia and woundinfection occured and only minimal adhesions to the intestine were measured. The histological analysis showed good vascularisation and migration of cells. The immune response that developes with Lyoplant® seems more like a process of remodelling than rejection. Our results indicate that biocompatible materials can also be used for the therapy of congenital abdominal wall defects
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Wilms, Christian. "Angiographische und duplexsonographische Untersuchungen der Leberperfusion nach subtotaler arterieller oder portaler Okklusion der Leber am Mini-Pig-Modell /." 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014629117&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Seifert, Adrian [Verfasser]. "Histologische Analyse der Remodulierungsvorgänge eines biokompatiblen Kollagen-Meshs zur Therapie kongenitaler Bauchwanddefekte im Mini-Pig-Modell / vorgelegt von Adrian Seifert." 2009. http://d-nb.info/997149515/34.

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Hammerich, Kai Hans [Verfasser]. "Einfluss verschiedener OP-Techniken auf die Hämodynamik der Leberperfusion : eine Untersuchung am Small-for-size-mini-pig-Modell / vorgelegt von Kai Hans Hammerich." 2006. http://d-nb.info/980183669/34.

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Book chapters on the topic "Mini-pig model"

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Evan, Andrew P., James A. McAteer, Christopher P. Steidle, Lynn R. Willis, Nancy M. Hockley, Richard Saint, Anne Hawk, Bret A. Connors, Stephen A. Kempson, and James E. Lingeman. "The Mini-Pig: An Ideal Large Animal Model for Studies of Renal Injury in Extracorporeal Shock Wave Lithotripsy Research." In Shock Wave Lithotripsy 2, 35–40. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-2052-5_8.

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Hillert, C., L. Mueller, A. Paetz, W. Notarp, K. Schroeder, K. Helmke, G. Krupski, A. Koops, D. C. Broering, and X. Rogiers. "Der TIPSS zur Therapie des portalen Hyperperfusionssyndrom. Erste Erfahrungen am Small-for-Size Mini-Pig-Modell." In Deutsche Gesellschaft für Chirurgie, 323–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18547-2_100.

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Lee, Woon Kyu. "Research on Gastric Ulcer Model in Mini-Pig." In Current Research in Agriculture and Veterinary Sciences Vol. 3, 78–85. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/cravs/v3/9461d.

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Conference papers on the topic "Mini-pig model"

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Yates, Keegan, Elizabeth Fievisohn, Warren Hardy, and Costin Untaroiu. "Development and Validation of a Göttingen Miniature Pig Brain Finite Element Model." In ASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/detc2016-60217.

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The Center for Disease Control and Prevention reports that there are approximately 1.4 million emergency department visits, hospitalizations, or deaths per year in the USA due to traumatic brain injuries (TBI) [1]. In order to lessen the severity or prevent TBIs, accurate dummy models, simulations, and injury risk metrics must be used. Ideally, these models and metrics would be designed with the use of human data. However, available human data is sparse, so animal study data must be applied to the human brain. Animal data must be scaled before it can be applied, and current scaling methods are very simplified. The objective of our study was to develop a finite element (FE) model of a Göttingen mini-pig to allow study of the tissue level response under impact loading. A hexahedral FE model of a miniature pig brain was created from MRI images. The cerebrum, cerebellum, corpus callosum, midbrain, brainstem, and ventricles were modeled and assigned properties as a Kelvin-Maxwell viscoelastic material. To validate the model, tests were conducted using mini-pigs in an injury device that subjected the pig brain to both linear and angular motion. These pigs are commonly used for brain testing because the brains are well developed with folds and the material properties are similar to human brain. The pigs’ brains were embedded with neutral density radio-opaque markers to track the motion of the brain relative to the skull with a biplanar X-ray system. The impact was then simulated, and the motion of nodes closest to the marker locations was recorded and used to optimize material parameters and the skull-brain interface. The injuries were defined at a tissue level with damage measures such as cumulative strain damage measure (CSDM). In future the animal FE model could be used with a human FE model to determine an accurate animal-to-human transfer function.
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Thompson, Kimberly A., Adam C. Sokolow, Juliana Ivancik, Timothy G. Zhang, William H. Mermagen, and Sikhanda S. Satapathy. "A Sensitivity Study of the Porcine Head Subjected to Bump Impact." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-68178.

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Understanding load transfer to the human brain is a complex problem that has been a key subject of recent investigations [4–6]. Because the porcine is a gyrencephalic species, having greater structural and functional similarities to the human brain than other lower species outlined in the literature, it is commonly chosen as a surrogate for human brain studies [7]. Consequently, we have chosen to use a porcine model in this work. To understand stress wave transfer to and through the brain, it is important to fully characterize the nature of the impact (i.e. source, location, and speed) as well as the response of the constituent tissues under such impact. We suspect the material and topology of these tissues play an important role in their response. In this paper, we report on a numerical study assessing the sensitivity of model parameters for a 6-month old Gottingen mini-pig model, under bump loading. In this study, 2D models are used for computational simplicity. While a 3D model is more realistic in nature, a 2D representation is still valuable in that it can provide trends on parameter sensitivity that can help steer the development of the 3D model. In this work, we investigate the variation of skull and skin thickness, evaluate material variability of the skull, and consider the effects of nasal cavities on load transfer. Eighty simulations are computed in LS-DYNA and analyzed in MATLAB. The results of this study will provide useful knowledge on the necessary components and parameters of the porcine model and therefore provide more confidence in the analysis. This is an essential first step as we look toward bridging the gap between correlates of injury in animal and human models.
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