Relevant bibliographies by topics / Mimosin / Journal articles
To see the other types of publications on this topic, follow the link: Mimosin.

Journal articles on the topic 'Mimosin'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Mimosin.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Szyszka, M., S. Posri, and U. Meulen. "Die Bestimmung des „acceptable daily intake” für Mimosin bei Kaninchen." Zeitschrift für Tierphysiologie Tierernährung und Futtermittelkunde 54, no. 1-5 (October 9, 2009): 156–60. http://dx.doi.org/10.1111/j.1439-0396.1985.tb01528.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Padmiswari, A. A. Istri Mas, Ngurah Intan Wiratmini, and I. Wayan Kasa. "HISTOLOGI TESTIS TIKUS (Rattus norvegicus) JANTAN YANG DIBERI TEPUNG DAUN LAMTORO (Leucaena leucocephala Lamk. de Wit) HASIL PERENDAMAN." Metamorfosa: Journal of Biological Sciences 4, no. 2 (October 18, 2017): 178. http://dx.doi.org/10.24843/metamorfosa.2017.v03.i02.p07.

Full text
Abstract:
Lamtoro merupakan salah satu tanaman yang memiliki kandungan protein yang cukup tinggi yaitu berkisar antara 25-35%. Namun, pemanfaatan lamtoro menjadi terbatas karena mengandung zat antinutrisi seperti mimosin. Kandungan mimosin dapat diturunkan melalui beberapa metode salah satunya adalah melalui perendaman dalam air. Penelitian ini bertujuan untuk mengetahui pengaruh dari pemberian tepung daun lamoro hasil perendaman (TDLP) terhadap histologi testis tikus jantan. Rancangan percobaan yang digunakan adalah Rancangan Acak Lengkap (RAL) yang terdiri dari empat kelompok dengan masing-masing delapan ulangan. Perlakuan berupa pemberian tepung daun lamtoro hasil perendaman yang dicampur dengan pelet komersial dengan aras 100% pakan komersial (tanpa TDLP) sebagai kontrol (P0), 92,5% pakan komersial + 7,5% TDLP sebagai perlakuan 1 (P1), 85% pakan komersial + 15% TDLP sebagai perlakuan 2 (P2) dan 77,5% pakan komersial + 22,5% TDLP sebagai perlakuan 3 (P3). Perlakuan diberikan pada tikus jantan selama 30 hari. Variabel yang diamati pada penelitian ini adalah jumlah sel spermatogenik. Data hasil penelitian diolah menggunakan program statistik komputer (SPSS 16.0 for Windows) dengan menggunakan uji One Way Anova. Hasil penelitian menunjukkan bahwa penambahan TDLP dalam ransum tidak berpengaruh nyata (P>0,05) terhadap jumlah sel spermatogenik. Hal ini menunjukkan bahwa penambahan TDLP hingga aras 22,5% tidak menurunkan jumlah sel spermatogenik.
APA, Harvard, Vancouver, ISO, and other styles
3

Szyszka, M., and U. Meulen. "Das Verhalten von Schafen gegenüber dem toxischen Mimosin in Leucaena leucocephala." Zeitschrift für Tierphysiologie Tierernährung und Futtermittelkunde 53, no. 1-5 (October 9, 2009): 65–69. http://dx.doi.org/10.1111/j.1439-0396.1985.tb00008.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Szyszka, M., N. Potikanond, and U. Meulen. "Leucaena leucocephala in der Rinderfütterung - der, ”acceptable daily intake„ für Mimosin bei Rindern." Zeitschrift für Tierphysiologie Tierernährung und Futtermittelkunde 52, no. 1-5 (October 9, 2009): 248–54. http://dx.doi.org/10.1111/j.1439-0396.1984.tb00835.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Suharti, Sri, Windawati Alwi, and Komang Gede Wiryawan. "Isolasi Bakteri Pendegradasi Mimosin Asal Rumen Sapi dan Domba yang Diberi Daun Lamtoro dan Pengaruhnya Pada Karakteristik Fermentasi In Vitro." Sains Peternakan 18, no. 1 (March 1, 2020): 23. http://dx.doi.org/10.20961/sainspet.v18i1.33228.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Yanuartono, Yanuartono, Soedarmanto Indarjulianto, Alfarisa Nururrozi, Slamet Raharjo, and Hary Purnamaningsih. "Brief Review: The Negative Impact Of Mimosin in L. leucocephala in Ruminant Animals and Processing Methods to Reduce Poisoning Effects on Ruminant Livestock." Journal of Livestock Science and Production 3, no. 2 (November 21, 2019): 199–213. http://dx.doi.org/10.31002/jalspro.v3i2.2037.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Silva, Rosilene Rodrigues, and Ana Maria Goulart de Azevedo Tozzi. "Uma nova espécie de Mimosa L. (Leguminosae, Mimosoideae) do Centro-Oeste do Brasil." Hoehnea 38, no. 1 (March 2011): 143–46. http://dx.doi.org/10.1590/s2236-89062011000100013.

Full text
Abstract:
Uma nova espécie de Mimosa (Leguminosae, Mimosoideae, Mimosae) do estado do Mato Grosso do Sul, Centro-Oeste do Brasil, M. ferricola R.R. Silva & A.M.G. Azevedo, é descrita e ilustrada. Morfologicamente M. ferricola é relacionada com M. gemmulata Barneby e com M. nothopteris Barneby, e posicionada em Mimosa sect. Batocaulon DC. ser. Leiocarpae Benth.
APA, Harvard, Vancouver, ISO, and other styles
8

Silveira, Fernanda Schmidt, Silvia Teresinha Sfoggia Miotto, and João Ricardo Vieira Iganci. "Typification and taxonomy in Mimosa subser. Obstrigosae (Fabaceae, mimosoid clade)." Willdenowia 48, no. 3 (December 28, 2018): 443. http://dx.doi.org/10.3372/wi.48.48314.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

BURCKHARDT, DANIEL. "Queiroziella gen. nov., a new genus of jumping plant-lice (Hemiptera, Psyllidae) from Southern Brazil associated with Mimosa scabrella (Leguminosae)." Zootaxa 4927, no. 3 (February 15, 2021): 359–82. http://dx.doi.org/10.11646/zootaxa.4927.3.3.

Full text
Abstract:
Queiroziella gen. nov., a new genus of Psylloidea (Psyllidae, Ciriacreminae), is erected for five new species developing on the multipurpose tree Mimosa scabrella (Leguminosae, Caesalpinioideae, mimosoid clade): viz. Queiroziella erato sp. nov., Q. euterpe sp. nov., Q. melpomone sp. nov., Q. terpsichore sp. nov. and Q. thalia sp. nov. Another species from Paraguay, associated with an unidentified Mimosa species, is transferred to the new genus as Queiroziella borealis (Burckhardt, 1987), comb. nov., from Zonopelma (Aphalaroidinae). The new taxa are diagnosed, described and illustrated, and keys are provided for the identification of adults and immatures. Morphologically, Queiroziella resembles Heteropsylla which is also associated with mimosoid legumes and with which it may be closely related. As their host, the new species are restricted to Southern Brazil. Queiroziella euterpe, Q. melpomone and Q. terpsichore are reported from the states of Paraná, Rio Grande do Sul, Santa Catarina and São Paulo, Q. thalia from Paraná and São Paulo, and Q. erato from Paraná. No clear phenological patterns were found though it seems that high psyllid populations coincide with new flush of the host plants. Despite that the psyllids occur sometimes in very high numbers, no visible damage could be detected on host trees. On the other hand, the honeydew of the psyllids may provide a food source for honey-bees during non-flowering periods of Mimosa scabrella.
APA, Harvard, Vancouver, ISO, and other styles
10

Wang, En Tao, M. Antonio Rogel, Alejandro Garcia-de los Santos, Julio Martinez-Romero, Miguel A. Cevallos, and Esperanza Martínez-Romero. "Rhizobium etli bv. mimosae, a novel biovar isolated from Mimosa affinis." International Journal of Systematic and Evolutionary Microbiology 49, no. 4 (October 1, 1999): 1479–91. http://dx.doi.org/10.1099/00207713-49-4-1479.

Full text
APA, Harvard, Vancouver, ISO, and other styles
11

Rezende, Denise V., and José C. Dianese. "Revisão taxonômica de algumas espécies de Ravenelia em leguminosas do Cerrado brasileiro." Fitopatologia Brasileira 28, no. 1 (January 2003): 27–36. http://dx.doi.org/10.1590/s0100-41582003000100004.

Full text
Abstract:
Oito espécies de Ravenelia descritas anteriormente foram revisadas e acrescentadas ilustrações inéditas das características morfológicas de alguns desses fungos causadores de ferrugem em Leguminosae. As espécies de Ravenelia estudadas foram: Ravenelia bezerrae sobre Enterolobium ellipticum ; R. densifera sobre Senna silvestris; R. dieteliana sobre Calliandra dysantha. var. dysantha; R. geminipora sobre Platymenia reticulata; R. lonchocarpi sobre Lonchocarpus campestris; R. mimosae-sensitivae sobre Mimosa radula var. imbricata; R. pileolarioides sobre Caesalpinia pyramydales e R. santos-costae, sobre Calliandra dysantha.
APA, Harvard, Vancouver, ISO, and other styles
12

Borges, Leonardo Maurici, Marcelo Fragomeni Simon, and José Rubens Pirani. "Less is more. Adjusting the taxonomy of the polytypic Mimosa setosa (Leguminosae, Mimosoid)." Rodriguésia 68, no. 2 (June 2017): 515–40. http://dx.doi.org/10.1590/2175-7860201768215.

Full text
Abstract:
Resumo Mimosa setosa, em sua circunscrição atual, é uma espécie politípica que inclui quatro subespécies e oito variedades. Estudos filogenéticos recentes indicam que esses táxons infraespecíficos não formam um grupo monofilético. A análise morfológica de um conjunto de espécimes obtidos em diversos herbários, incluindo tipos e coletas recentes, associada à aplicação do Conceito Filogenético de espécie permite desmembrar M. setosa em seis diferentes espécies sem táxons infraespecíficos. Congruência entre dados filogenéticos, geografia e adoção do nível de espécie como a unidade mínima para descrição de táxons permite uma melhor comparação da diversidade biológica e uma circunscrição mais adequada dos táxons envolvidos no complexo M. setosa.
APA, Harvard, Vancouver, ISO, and other styles
13

Hoover, Marjorie L., and Anselm Glück. "eiserne mimosen." World Literature Today 72, no. 1 (1998): 125. http://dx.doi.org/10.2307/40153589.

Full text
APA, Harvard, Vancouver, ISO, and other styles
14

Chen, Wen-Ming, Euan K. James, Alan R. Prescott, Martin Kierans, and Janet I. Sprent. "Nodulation of Mimosa spp. by the β-Proteobacterium Ralstonia taiwanensis." Molecular Plant-Microbe Interactions® 16, no. 12 (December 2003): 1051–61. http://dx.doi.org/10.1094/mpmi.2003.16.12.1051.

Full text
Abstract:
Several β-proteobacteria have been isolated from legume root nodules and some of these are thought to be capable of nodulating and fixing N2. However, in no case has there been detailed studies confirming that they are the active symbionts. Here, Ralstonia taiwanensis LMG19424, which was originally isolated from Mimosa pudica nodules, was transformed to carry the green fluorescent protein (gfp) reporter gene before being used to inoculate axenically-grown seedlings of M. pudica and M. diplotricha. Plants were harvested at various intervals for 56 days after inoculation, then examined for evidence of infection and nodule formation. Nodulation of both Mimosa spp. was abundant, and acetylene reduction assays confirmed that nodules had nitrogenase activity. Confocal laser scanning microscopy (CLSM) showed that fresh M. pudica nodules with nitrogenase activity had infected cells containing bacteroids expressing gfp. In parallel, fixed and embedded nodules from both Mimosa spp. were sectioned for light and electron microscopy, followed by immunogold labeling with antibodies raised against gfp and nitrogenase Fe (nifH) protein. Significant immunolabeling with these antibodies confirmed that R. taiwanensis LMG19424 is an effective N2-fixing symbiont of Mimosa spp. Both species were infected via root hairs and, in all respects, the nodule ontogeny and development was similar to that described for other mimosoid legumes. The nodules were indeterminate with a persistent meristem, an invasion zone containing host cells being invaded via prominent infection threads, and an N2-fixing zone with infected cells containing membrane-bound symbiosomes.
APA, Harvard, Vancouver, ISO, and other styles
15

Yang, Xiaoyue, Xiyou Qian, and Zefu Wang. "The complete chloroplast genome of Mimosa pudica and the phylogenetic analysis of mimosoid species." Mitochondrial DNA Part B 3, no. 2 (July 3, 2018): 1265–66. http://dx.doi.org/10.1080/23802359.2018.1532831.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

Fox, P. M., and D. Borthakur. "Selection of several classes of mimosine-degradation-defective Tn3Hogus-insertion mutants of Rhizobium sp. strain TAL1145 on the basis of mimosine-inducible GUS activity." Canadian Journal of Microbiology 47, no. 6 (June 1, 2001): 488–94. http://dx.doi.org/10.1139/w01-042.

Full text
Abstract:
Rhizobium sp. strain TAL1145 that nodulates Leucaena leucocephala degrades mimosine, a toxin produced by this tree legume. A cosmid clone, pUHR263, containing ~25 kb cloned DNA was isolated by plating Escherichia coli cells containing the cosmid clone library of TAL1145 on a minimal medium in which 3-hydroxy-4-pyridone (HP), a degradation product of mimosine, was used as the source of nitrogen. Cosmid pUHR263 was mutagenized by random insertions of Tn3Hogus, a transposon that makes transcriptional gus fusions when it is inserted in a gene in the correct orientation. Various pUHR263::Tn3Hogus derivatives that showed mimosine-inducible or mimosine-repressible GUS activities when transferred to the Rhizobium sp. strain TAL1145 were selected. Mutants of TAL1145 were constructed by transferring these Tn3Hogus insertions into the TAL1145 chromosome through double-homologous recombination. These mutants were classified into five classes on the basis of defects in mimosine degradation. The growth of these mutants was inhibited to different extents by mimosine applied to the growth medium. Mimosine forms a red-colored Fe-mimosine complex when FeCl3 is added to the medium. The inhibitory effect of Fe-mimosine on growth of the mutants was much less than that of mimosine.Key words: mimosine, mid and pyd genes, Leucaena leucocephala, tree legume, Tn3Hogus.
APA, Harvard, Vancouver, ISO, and other styles
17

Kostermans, D. "Notes on mimosine." Recueil des Travaux Chimiques des Pays-Bas 65, no. 4 (September 3, 2010): 319. http://dx.doi.org/10.1002/recl.19460650413.

Full text
APA, Harvard, Vancouver, ISO, and other styles
18

Yeung, Patrick K. K., Francis T. W. Wong, and Joseph T. Y. Wong. "Mimosine, the Allelochemical from the Leguminous Tree Leucaena leucocephala, Selectively Enhances Cell Proliferation in Dinoflagellates." Applied and Environmental Microbiology 68, no. 10 (October 2002): 5160–63. http://dx.doi.org/10.1128/aem.68.10.5160-5163.2002.

Full text
Abstract:
ABSTRACT Mimosine, the allelochemical from the leguminous tree Leucaena leucocephala, is toxic to most terrestrial animals and plants. We report here that while mimosine inhibits major phytoplankton groups, it enhances cell proliferation in dinoflagellates. On addition to coastal seawater samples, mimosine is able to confer a growth advantage to dinoflagellates. The use of mimosine will promote the isolation and culture of this group of phytoplankton.
APA, Harvard, Vancouver, ISO, and other styles
19

Chung, Li-Chuan, Ke-Hung Tsui, Tsui-Hsia Feng, Shiow-Ling Lee, Phei-Lang Chang, and Horng-Heng Juang. "l-Mimosine blocks cell proliferation via upregulation of B-cell translocation gene 2 and N-myc downstream regulated gene 1 in prostate carcinoma cells." American Journal of Physiology-Cell Physiology 302, no. 4 (February 15, 2012): C676—C685. http://dx.doi.org/10.1152/ajpcell.00180.2011.

Full text
Abstract:
l-Mimosine, an iron chelator and a prolyl 4-hydroxylase inhibitor, blocks many cancer cells at the late G1 phase. B-cell translocation gene 2 ( Btg2) regulates the G1/S transition phases of the cell cycle. N- myc downstream regulated gene 1 ( Ndrg1) is a differentiation-inducing gene upregulated by hypoxia. We evaluated the molecular mechanisms of l-mimosine on cell cycle modulation in PC-3 and LNCaP prostate carcinoma cells. The effect of l-mimosine on cell proliferation of prostate carcinoma cells was determined by the [3H]thymidine incorporation and flow cytometry assays. l-Mimosine arrested the cell cycle at the G1 phase in PC-3 cells and at the S phase in LNCaP cells, thus attenuating cell proliferation. Immunoblot assays indicated that hypoxia and l-mimosine stabilized hypoxia-inducible factor-1α (HIF-1α) and induced Btg2 and Ndrg1 protein expression, but downregulated protein levels of cyclin A in both PC-3 and LNCaP cells. l-Mimosine treatment decreased cyclin D1 protein in PC-3 cells, but not in LNCaP cells. Dimethyloxalylglycine, a pan-prolyl hydroxylase inhibitor, also induced Btg2 and Ndrg1 protein expression in LNCaP cells. The transient gene expression assay revealed that l-mimosine treatment or cotransfection with HIF-1α expression vector enhanced the promoter activities of Btg2 and Ndrg1 genes. Knockdown of HIF-1α attenuated the increasing protein levels of both Btg2 and Ndrg1 by hypoxia or l-mimosine in LNCaP cells. Our results indicated that hypoxia and l-mimosine modulated Btg2 and Ndrg1 at the transcriptional level, which is dependent on HIF-1α. l-Mimosine enhanced expression of Btg2 and Ndrg1, which attenuated cell proliferation of the PC-3 and LNCaP prostate carcinoma cells.
APA, Harvard, Vancouver, ISO, and other styles
20

Hallak, Maher, Alexander Dvilansky, Ofer Shpilberg, Itai Levi, Julia Mazar, and Ilana Nathan. "Mimosine Induces Apoptosis through Metal Ion Chelation, Mitochondrial Activation and Reactive Oxygen Species Production in Human Leukemic Cells." Blood 104, no. 11 (November 16, 2004): 4481. http://dx.doi.org/10.1182/blood.v104.11.4481.4481.

Full text
Abstract:
Abstract Mimosine, a non-protein amino acid, acts as a reversible inhibitor of DNA replication, and is widely used to synchronize cells at G1 phase of the cell cycle. We tested the possibility that mimosine might have an apoptotic effect on two types of AML cells: the monoblastic U-937 and the promyelocytic HL-60 cell lines. We show that mimosine induces apoptosis in both cell lines, with U-937 cells being more sensitive. The apoptotic effect of mimosine was antagonized by the addition of exogenous iron, indicating that it may act through iron chelation. Its mode of action was thus compared to that of desferrioxamine (DFO), a therapeutic iron chelating agent. Mimosine and DFO differed in their sensitivity to the suppressive effect of exogenous sources of iron in the form of hemin and ferrous sulfate suggesting different targets of action. Addition of another metal ion cupric sulfate was also able to antagonize the apoptotic effect of mimosine, undermining the notion that apoptosis is mediated through inhibition of ribonucleotide reductase, since this enzyme is solely dependent on iron for its activity. Moreover, when higher concentrations of iron were added to mimosine, cell death shifted from apoptosis to necrosis. Induction of apoptosis by both mimosine and DFO caused an early reduction in mitochondrial transmembrane potential and increase in caspase-3 activity, while only mimosine induced oxidative stress. In summary, our results imply that besides its known effect on DNA synthesis and G1 arrest, mimosine also activates apoptosis through an intrinsic pathway as well as reactive oxygen species production and thus elicits its anticancer effect by multiple pathways.
APA, Harvard, Vancouver, ISO, and other styles
21

Libon, C., N. Steward, A. Cousy, J. Rouquet, C. Issac-Visentin, A. Grondin, Y. Brunel, A. Latil, and T. Nguyen. "1074 Mimosa pudica plant cell culture extracts (mimosine free) exhibit anti-inflammatory activities and inhibit the responses in vitro." Journal of Investigative Dermatology 138, no. 5 (May 2018): S182. http://dx.doi.org/10.1016/j.jid.2018.03.1087.

Full text
APA, Harvard, Vancouver, ISO, and other styles
22

Honda, Michael D. H., and Dulal Borthakur. "Mimosine concentration in Leucaena leucocephala under various environmental conditions." Tropical Grasslands-Forrajes Tropicales 7, no. 2 (May 31, 2019): 164–72. http://dx.doi.org/10.17138/tgft(7)164-172.

Full text
Abstract:
Keynote paper presented at the International Leucaena Conference, 1‒3 November 2018, Brisbane, Queensland, Australia.Leucaena leucocephala (leucaena) is a multipurpose tropical tree-legume that is highly resistant to many biotic and abiotic stresses. Leucaena is used primarily as an animal fodder owing to its protein-rich foliage. However, leucaena foliage also contains mimosine, a toxic non-protein amino acid that can cause alopecia, goiter and other thyroid problems, infertility, and fetal death. Considering its toxicity and abundance in leucaena, it is important to quantify the mimosine concentrations in leucaena under different environmental conditions. Mimosine was extracted from various types of leucaena tissue exposed to a range of environmental conditions and then quantified by HPLC. The mimosine concentrations in leucaena treated with NaCl increased after 6 days of treatment and remained relatively high when treatment continued for 18 days. Interestingly, leucaena exposed to complete darkness for up to 5 days had a higher mimosine concentration than control plants exposed to normal light/dark photoperiods. On the other hand, drying leucaena leaflets or macerating them in an alkaline buffer significantly lowered their mimosine concentration. Mature leaflets that had fallen off the plant and dried out also contained significantly less mimosine than fresh leaflets. The results of this study indicate that mimosine concentrations in leucaena are affected by environmental conditions and this knowledge can assist in managing to prevent toxicity.
APA, Harvard, Vancouver, ISO, and other styles
23

Chen, Xin Zhu, Fan Feng, Qin Hua Liu, and Jian Guo Zhang. "Degrading Mimosine and Tannins of Leucaena leucocephala by Ensiling." Applied Mechanics and Materials 618 (August 2014): 349–53. http://dx.doi.org/10.4028/www.scientific.net/amm.618.349.

Full text
Abstract:
Lucaena (Leucaena leucocephala) is a valuable fodder tree, but it contains high contents of anti-nutritional factors, such as mimosine and tannins. The present study investigated the silage fermentation characteristics and ensiling effects on the degradation of mimosine and tannins of leucaena. Mimosine and tannins gradually reduced during ensiling, and sucrose and lactic acid bacteria (LAB) addition promoted their degradation. The highest degradation rate of mimosine was 49.0% in sucrose treatment and the lowest was 25.5% in the control. The highest degradation rate of tannins was 54.7% in the combined treatment of sucrose and LAB and the lowest was 40% in the control. The degradation rates of mimosine and tannins had negative correlation with the pH value and had positive correlation with lactic acid content in silage.
APA, Harvard, Vancouver, ISO, and other styles
24

Bellés-Sancho, Paula, Martina Lardi, Yilei Liu, Sebastian Hug, Marta Adriana Pinto-Carbó, Nicola Zamboni, and Gabriella Pessi. "Paraburkholderia phymatum Homocitrate Synthase NifV Plays a Key Role for Nitrogenase Activity during Symbiosis with Papilionoids and in Free-Living Growth Conditions." Cells 10, no. 4 (April 20, 2021): 952. http://dx.doi.org/10.3390/cells10040952.

Full text
Abstract:
Homocitrate is an essential component of the iron-molybdenum cofactor of nitrogenase, the bacterial enzyme that catalyzes the reduction of dinitrogen (N2) to ammonia. In nitrogen-fixing and nodulating alpha-rhizobia, homocitrate is usually provided to bacteroids in root nodules by their plant host. In contrast, non-nodulating free-living diazotrophs encode the homocitrate synthase (NifV) and reduce N2 in nitrogen-limiting free-living conditions. Paraburkholderia phymatum STM815 is a beta-rhizobial strain, which can enter symbiosis with a broad range of legumes, including papilionoids and mimosoids. In contrast to most alpha-rhizobia, which lack nifV, P. phymatum harbors a copy of nifV on its symbiotic plasmid. We show here that P. phymatum nifV is essential for nitrogenase activity both in root nodules of papilionoid plants and in free-living growth conditions. Notably, nifV was dispensable in nodules of Mimosa pudica despite the fact that the gene was highly expressed during symbiosis with all tested papilionoid and mimosoid plants. A metabolome analysis of papilionoid and mimosoid root nodules infected with the P. phymatum wild-type strain revealed that among the approximately 400 measured metabolites, homocitrate and other metabolites involved in lysine biosynthesis and degradation have accumulated in all plant nodules compared to uninfected roots, suggesting an important role of these metabolites during symbiosis.
APA, Harvard, Vancouver, ISO, and other styles
25

Klykleung, Nattaporn, Masahiro Yuki, Takuji Kudo, Moriya Ohkuma, Wongsakorn Phongsopitanun, Yuki Inahashi, Atsuko Matsumoto, and Somboon Tanasupawat. "Streptomyces mimosae sp. nov., an endophytic actinomycete isolated from the root of Mimosa pudica in Thailand." International Journal of Systematic and Evolutionary Microbiology 70, no. 5 (May 1, 2020): 3316–22. http://dx.doi.org/10.1099/ijsem.0.004170.

Full text
Abstract:
An endophytic actinomycete, strain 3MP-10T, isolated from the root of Mimosa pudica was taxonomically studied based upon polyphasic approaches. This strain formed spiral spore chains on aerial mycelia. ll-Diaminopimelic acid, glucose and ribose were found in the whole-cell hydrolysates. It belonged to the genus Streptomyces and was closely related to Streptomyces zhaozhouensis DSM 42101T (98.9 %) and Streptomyces sedi JCM 16909T (98.6 %) based on 16S rRNA gene sequence analysis results. The major menaquinones were MK-10(H8), MK-10(H6) and MK-9(H8). The predominant cellular fatty acids were iso-C16 : 0, anteiso-C15 : 0 and anteiso-C17 : 0. The detected phospholipids were diphosphatidylglycerol, phosphatidylinositol mannoside, phosphatidylinositol, phosphatidylethanolamine and phosphatidylglycerol. Strain 3MP-10T had a genome size of 7.2 Mb with a genome G+C content of 73.4 mol%. Results of in silico genome-based similarity analysis revealed ANIb values of 84.94 and 84.77 %, ANIm values of 88.01 and 87.92 %, and dDDH values of 29.9 and 29.6 % when compared with S. zhaozhouensis DSM 42101T and S. sedi JCM 16909T, respectively. Based on the polyphasic approach, digital DNA–DNA relatedness and average nucleotide identity, we propose that the novel actinomycete represents a novel species, Streptomyces mimosae, with type strain 3MP-10T (=JCM 33328T=TISTR 2646T).
APA, Harvard, Vancouver, ISO, and other styles
26

Ogita, Shinjiro, Misako Kato, Shin Watanabe, and Hiroshi Ashihara. "The Co-Occurrence of Two Pyridine Alkaloids, Mimosine and Trigonelline, in Leucaena leucocephala." Zeitschrift für Naturforschung C 69, no. 3-4 (April 1, 2014): 124–32. http://dx.doi.org/10.5560/znc.2013-0137.

Full text
Abstract:
Leucaena leucocephala is a nitrogen-fixing tropical leguminous tree that produces two pyridine alkaloids, i. e. mimosine [β-(3-hydroxy-4-pyridon-1-yl)-L-alanine] and trigonelline (1- methylpyridinium-3-carboxylate). Mimosine has been detected in leaves, flowers, pods, seeds, and roots, and it is one of the principal non-protein amino acids that occurs in all organs. Asparagine was the most abundant amino acid in flowers. The mimosine content varied from 3.3 μmol/g fresh weight (FW) in developing flowers to 171 μmol/g FW in mature seeds. Trigonelline was also detected in leaves, flowers, pods, and seeds, but not roots. The trigonelline content was lower than that of mimosine in all organs. It varied from 0.12 μmol/g FW in developing seeds to 2.6 μmol/g FW in mature seeds. [2-14C]Nicotinic acid supplied to the developing seeds was incorporated into trigonelline but not mimosine. This indicates that the pyridine and dihydroxypyridine structures of these two alkaloids are derived from distinct precursors. The physiological functions of mimosine and trigonelline are discussed briefly.
APA, Harvard, Vancouver, ISO, and other styles
27

Puchala, R., S. G. Pierzynowski, T. Sahlu, and S. P. Hart. "Effects of mimosine administered to a perfused area of skin in Angora goats." British Journal of Nutrition 75, no. 1 (January 1996): 69–79. http://dx.doi.org/10.1079/bjn19960111.

Full text
Abstract:
The effect of mimosine on a perfused area of skin tissue was studied using an isolated perfusion technique. Four mature Angora wethers (body weight 35 (SE 2·3) kg) were cannulated bilaterally with indwelling silicone catheters in the superficial branches of the deep circumflex iliac artery and vein. Mimosine (40 mg/kg metabolic weight (W0·75) per d) was infused intra-arterially into one iliac artery of each goat for 3 d and saline was infused in the contralateral (control) iliac artery. Iliac venous blood samples were taken from both sides along with arterial samples from the carotid artery. Mimosine infusion elevated plasma mimosine in the carotid artery (52·6 (SEM 19·21)µmol/I) and iliac vein on the saline-treated side to 54·1 (SEM 16·31)µ/I and in the iliac vein on the mimosine-treated side to 191·3 (SEM19·14) µmol/I (P < 0·01). Mimosine decreased feed intake (2·3 v. 0·6 kg/d, SEM 0·29; P < 0·001) and water consumption (5·2 v. 1·3 litres/d, SEM 0·67; P < 0·001). Mimosine did not cause defleecing in the area of infusion and was cleared from the bloodstream within 12 h of cessation of infusion. The following effects were also observed during mimosine infusion: decrease in plasma amino acids to half pre-infusion values (methionine 22·7 v. 13·1 µmol/l, SEM 1·41; lysine 95·9 p. 37·4 µmol/l, SEM 4·28; P < 0·001); decreases in plasma triiodothyronine (1495 v. 695 ng/l, SEM 43·1; P < 0·001), thyroxine (61·5 v. 19·5 µg/l, SEM 1·8; P < 0·001) and insulin (28·7 v. 17·3 µIU/ml, SEM 1·89; P < 0·01) concentrations; increase in plasma cortisol (14 v. 62 µg/l, SEM 0·35; P < 0·001) concentration; decreases in levels of plasma Zn and Mg (0·97. v. 0·49 mg/l, SEM 0·063; P < 0·001 and 21·4 v. 14·6 mg/l, SEM 1·74; P < 0·001 respectively). All reported variables returned to their normal values 24 h after cessation of mimosine infusion except feed intake which was affected for a longer period. Mohair length and diameter were not affected by mimosine infusion. The toxicity of mimosine may be due to the drastic depletion of Zn and Mg in the blood as mimosine possesses very strong chelating properties and is excreted in the urine as a chelate.
APA, Harvard, Vancouver, ISO, and other styles
28

Elliott, R., BW Norton, JTB Milton, and CW Ford. "Effects of molasses on mimosine metabolism in goats fed fresh and dried Leucaena with barley straw." Australian Journal of Agricultural Research 36, no. 6 (1985): 867. http://dx.doi.org/10.1071/ar9850867.

Full text
Abstract:
The effect of molasses supplementation on the metabolism and excretion of mimosine by goats was studied. Goats were fed barley straw and Leucaena (31.0 g mimosine kg-1 dry matter) throughout experiment 1 with and without a molasses supplement (400 g day-1). Four groups of four goats fed barley straw (13 days) were supplemented with either 0, 100, 200 or 400 g molasses day-1 for 6 days (experiment 2). Two goats on each molasses treatment were then offered similar quantities of Leucaena dry matter (DM) (10.0 g mimosine kg-1 DM) as either fresh or dried material for a further 18 days. Unsupplemented goats excreted appreciable quantities of mimosine and 3-hydroxy-4-(1H)-pyridone (DHP) in faeces. In experiment 1, 57% of the ingested mimosine was recovered, principally as conjugated DHP, in faeces and urine of goats supplemented with molasses, compared to 39% for unsupplemented goats. Molasses supplementation also increased the faecal excretion of conjugated DHP in experiment 2, particularly with goats fed dried Leucaena. Urinary excretion of mimosine in all goats was largely as conjugated DHP (negligible free DHP). The highest outputs of conjugated DHP in urine were associated with greater reductions in serum T4 levels, but 400 g of molasses supplement in experiment 2 prevented depressions in serum T4 levels. In both experiments a considerable proportion (c. 40%) of the ingested mimosine was not excreted.
APA, Harvard, Vancouver, ISO, and other styles
29

Dong, Zizheng, and Jian-Ting Zhang. "EIF3 p170, a Mediator of Mimosine Effect on Protein Synthesis and Cell Cycle Progression." Molecular Biology of the Cell 14, no. 9 (September 2003): 3942–51. http://dx.doi.org/10.1091/mbc.e02-12-0784.

Full text
Abstract:
l-Mimosine, a plant amino acid, can reversibly block mammalian cells at late G1 phase and has been suggested to affect translation of mRNAs such as p27, the CDK inhibitor. However, the mechanism of this effect is not known. Regulation of translation generally occurs at the initiation step that, in mammalian cells, is a complex process that requires multiple eukaryotic initiation factors (eIFs) and ribosome. The effects of mimosine on initiation factors or regulators consequently will influence translation initiation. P170, a putative subunit of eIF3, has been suggested to be nonessential for eIF3 function to form preinitiation complexes and it may function as a regulator for translation of a subset of mRNAs. In this article, we tested this hypothesis and investigated whether eIF3 p170 mediates mimosine effect on mRNA translation. We found that p170 translation was dramatically reduced by mimosine due to its iron-chelating function. The decreased expression of p170 by mimosine caused diminished de novo synthesis of tyrosinated α-tubulin and elevated translation of p27 before cell cycle arrest. These observations suggest that p170 is likely an early response gene to mimosine treatment and a mediator for mimosine effect on mRNA translation. The effect of p170 on the synthesis of tyrosinated α-tubulin and p27 in a reciprocal manner also suggests that p170 functions as a regulator for mRNA translation.
APA, Harvard, Vancouver, ISO, and other styles
30

Kostermans, D. "The structure of mimosine." Recueil des Travaux Chimiques des Pays-Bas 66, no. 2 (September 3, 2010): 93–98. http://dx.doi.org/10.1002/recl.19470660206.

Full text
APA, Harvard, Vancouver, ISO, and other styles
31

Kleipool, R. J. C., and J. P. Wibaut. "Mimosine (leucaenine) 5th communication )." Recueil des Travaux Chimiques des Pays-Bas 69, no. 1 (September 2, 2010): 37–44. http://dx.doi.org/10.1002/recl.19500690106.

Full text
APA, Harvard, Vancouver, ISO, and other styles
32

Bonting, Sj L., and F. R. Schepman. "Polarographic investigation of mimosine." Recueil des Travaux Chimiques des Pays-Bas 69, no. 8 (September 2, 2010): 1007–20. http://dx.doi.org/10.1002/recl.19500690809.

Full text
APA, Harvard, Vancouver, ISO, and other styles
33

Lin, Hong-bo, Rocco Falchetto, Paul J. Mosca, Jeffrey Shabanowitz, Donald F. Hunt, and Joyce L. Hamlin. "Mimosine Targets Serine Hydroxymethyltransferase." Journal of Biological Chemistry 271, no. 5 (February 1996): 2548–56. http://dx.doi.org/10.1074/jbc.271.5.2548.

Full text
APA, Harvard, Vancouver, ISO, and other styles
34

Frydas, S., M. Papazahariadou, N. Papaioannou, M. Hatzistilianou, M. Trakatellis, D. Merlitti, M. Di. Gioacchino, et al. "Effect of the Compound L-Mimosine in an in Vivo Model of Chronic Granuloma Formation Induced by Potassium Permanganate (KMNO4)." International Journal of Immunopathology and Pharmacology 16, no. 2 (May 2003): 99–104. http://dx.doi.org/10.1177/039463200301600202.

Full text
Abstract:
The plant amino acid L-mimosine has recently been suggested to inhibit cells at a regulatory step in late G phase before establishment of active DNA replication forks. In addition, L-mimosine is an extremely effective inhibitor of DNA replication in chromosomes of mammalian nuclei. In this work, the effect of L-mimosine on chronic inflammation induced by dorsal injections of 0.2 ml of a 1:40 saturated crystal solution of potassium permanganate in mice, was studied. Seven days afterwards, all mice developed a subcutaneous granulomatous tissue indicative of chronic inflammatory response at the site of infection. The intraperitoneal administration of L-mimosine (200 μg/dose) to the potassium permanganate treated mice for 5 consecutive days (the first at the same time of inoculation of the KMnO4), produced a significant decrease in size and weight of the granuloma when compared to mice not treated with L-mimosine (controls). In addition, in all mice treated with L-mimosine, there was a strong inhibition of tumor necrosis factor alpha that was revealed in the serum (P<0.05) and in the minced granulomas. Interleukin-6 was not detected in the serum of treated and untreated mice. These findings show for the first time, that L-mimosine may have an anti-inflammatory effect on chronic inflammation and an inhibitory effect on tumor necrosis factor alpha and interleukin-6 generation in supernatant fluids of minced granulomas.
APA, Harvard, Vancouver, ISO, and other styles
35

Mathews, Anne, and P. Vittal Rai. "Mimosine Content of Leucaena leucocephala and the Sensitivity of Rhizobium to Mimosine." Journal of Plant Physiology 117, no. 4 (January 1985): 377–82. http://dx.doi.org/10.1016/s0176-1617(85)80074-2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
36

Mladenov, Emil, and Boyka Anachkova. "DNA Breaks Induction by Mimosine." Zeitschrift für Naturforschung C 58, no. 9-10 (October 1, 2003): 732–35. http://dx.doi.org/10.1515/znc-2003-9-1024.

Full text
Abstract:
AbstractMouse erythroleukemic F4 N cells were treated with mimosine, etoposide, Fe(II)-EDTA, and Cu(II) in the presence of ascorbate. DNA was isolated and subjected to agarose gel electrophoresis and the size and distribution of the DNA fragments produced by the agents were compared. With increasing concentration of Cu(II) the production of DNA fragments was increased without decrease of the average length of the fragments, and their sizes were similar to those produced by etoposide as expected for cleavage of DNA at the nuclear matrix attachments sites. In contrast, mimosine and Fe(II) produced fragments of random size and with the progression of the reaction the average length of the fragments decreased. These results indicate that mimosine cuts DNA in a random fashion, regardless of its higher order chromatin organization. A conclusion is drawn that the DNA fragments obtained after mimosine treatment are a result of mimosine-assisted, Fe(II) dependent Fenton-like reactions randomly cutting chromosomal DNA.
APA, Harvard, Vancouver, ISO, and other styles
37

Wu, Cai Mei, Hong Min Yuan, Gang Jia, Zhi Sheng Wang, and Xiu Qun Wu. "Determination of Mimosine and 2,3-Dihydroxypyridine in Leucaena leucocephala by Reversed Phase High-Performance Liquid Chromatography." Applied Mechanics and Materials 140 (November 2011): 296–301. http://dx.doi.org/10.4028/www.scientific.net/amm.140.296.

Full text
Abstract:
A reversed high performance liquid chromatography method was developed for the quantitative determination of mimosine and 2,3-DHP in leaves ofLeucaena Leucocephala. Mimosine and 2,3DHP were extracted using 0.1N HCl.The chromatograph conditions were investigated and optimized. The optimal HPLC conditions as follows: Agilent HC-C18 column （4.6×150mm,5μm） was used at 30°C. The method used a variable wavelength UV detector at 280nm, the mobile phase consisted of 0.2 % (w/v) orthophosphoric acid and methanol, the gradient elution was adopted. The injection volume was 10μL. The linearity is favorable in the range of 1.0 to 50μg mL-1with a correlation coefficient of 0.99998 for mimosine and 0.99902 for 2,3DHP. Under the optimal conditions, the method limit of detection (LOD) of mimosine and 2,3DHP were 0.40mg/kg and 0.55mg/kg respectively. The recovery of mimosine was 87.00-94.70% with the RSD (n=5) of 2.75-3.81% in the spiked levels 0,1, 5, 20mg/g. At the same time, the recovery of 2,3DHP was 88-95.4% with the RSD (n=5) of 2.24-4.90%. The method was found to be simple, sensitive, fast and accurate, and has been applied successfully for the quantitative detection of mimosine and 2,3-DHP in leaves ofLeucaena Leucocephala, plasma and excretion of ruminant.
APA, Harvard, Vancouver, ISO, and other styles
38

Cliche, D. O., S. Girouard, N. Bissonnette, and D. J. Hunting. "Inhibition of ultraviolet B (UVB) induced apoptosis in A431 cells by mimosine is not dependent on cell cycle arrest." Canadian Journal of Physiology and Pharmacology 80, no. 7 (July 1, 2002): 650–53. http://dx.doi.org/10.1139/y02-075.

Full text
Abstract:
Ultraviolet (UV) radiation is a strong apoptotic trigger in many cell types. We have previously reported that a plant amino acid, mimosine (beta-[N-(3-hydroxy-4-pyridone)]-alpha-aminopropionic acid), with a well-known reversible G1 cell cycle arrest activity can inhibit apoptosis induced by UV irradiation and RNA polymerase II blockage in human A431 cells. Here, apoptosis was measured with a fluorimetric caspase activation assay. Interestingly, the protective state was effective up to 24 h following removal of mimosine from the culture medium while cells were progressing in the cell cycle. Our results demonstrate that the protective effect of mimosine against UV-induced apoptosis can be dissociated from its G1 cell-cycle arrest activity.Key words: mimosine, apoptosis, cell cycle, A431 cells, caspase activation assay.
APA, Harvard, Vancouver, ISO, and other styles
39

Sethi, Poonam, and Pushpa R. Kulkarni. "Leucaena Leucocephala a Nutrition Profile." Food and Nutrition Bulletin 16, no. 3 (September 1995): 1–16. http://dx.doi.org/10.1177/156482659501600307.

Full text
Abstract:
Leucaena leucocephala is one of the fastest-growing leguminous trees. Its foliage is used as animal feed, and its leaves and seeds are used as human food in Central America, Indonesia, and Thailand. Mimosine, the toxic, non-protein amino acid in Leucaena, causes alopecia, growth retardation, cataract, goitre, decreased fertility, and mortality in non-ruminants. The mechanism of this toxicity is complicated. Mimosine probably exerts its toxic action by blocking the metabolic pathways of aromatic amino acids and tryptophan; by chelating metals; by antagonizing the action of vitamin B6; by inhibiting DNA, RNA, and protein synthesis; by exerting adverse effects on collagen biosynthesis; and by interfering in the metabolism of some amino acids, primarily glycine. Besides mimosine, other anti-nutritional and toxic factors in L. leucocephala add to its toxicity. Heat, moisture, chemical treatments, ensiling, rotation feeding, cutting management of the plant, new hybrids, introducing micro-organisms into the rumen of ruminants that are unable to detoxify mimosine, and preparing protein isolate from Leucaena seeds have all been used to overcome mimosine toxicity.
APA, Harvard, Vancouver, ISO, and other styles
40

Honda, Michael D. H., and Dulal Borthakur. "Mimosine facilitates metallic cation uptake by plants through formation of mimosine–cation complexes." Plant Molecular Biology 102, no. 4-5 (January 6, 2020): 431–45. http://dx.doi.org/10.1007/s11103-019-00956-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
41

KUDO, H., K. J. CHENG, W. MAJAK, J. W. HALL, T. ARAI, Y. OKI, and J. W. COSTERTON. "IN VITRO DEGRADATION OF MIMOSINE BY MICROORGANISMS FROM THE ESOPHAGEAL SAC OF VOLES (Microtus arvalis)." Canadian Journal of Animal Science 66, no. 2 (June 1, 1986): 547–51. http://dx.doi.org/10.4141/cjas86-058.

Full text
Abstract:
The microbiota in the esophageal sac of voles fed either cubed alfalfa hay or concentrate pellets were assayed to determine their capacity to anaerobically degrade mimosine in vitro. Differences (P < 0.01) were found between the two diets during the growth phase. The sac contents of voles fed concentrate pellets degraded mimosine and 3-hydroxy-4-(1H)-pyridone (DHP) rapidly, but inocula from voles fed cubed alfalfa hay only hydrolyzed mimosine to DHP. Degradation of the pyridine ring occurred at the early stage of incubation, concurrently with microbial growth. Thereafter, degradation rates appear to have been almost negligible and very similar for both diets. These results agree with previous data obtained with ruminal microorganisms, where highly active inocula were also associated with animals on concentrate diets. Key words: Detoxification, hydrolysis, esophageal sac, mimosine, 3-hydroxy-4- (1H)-pyridone, voles
APA, Harvard, Vancouver, ISO, and other styles
42

Mikhailov, Ivailo, Petia Ninova, George Russev, and Boyka Anachkova. "Iron(II)-mimosine Catalyzed Cleavage of DNA." Zeitschrift für Naturforschung C 55, no. 9-10 (October 1, 2000): 849–51. http://dx.doi.org/10.1515/znc-2000-9-1031.

Full text
Abstract:
Abstract Supercoiled plasmid DNA was treated in vitro with H2O2, DTT and either Fe (II), Fe (II)-EDTA or Fe (II)- mimosine. The rate of DNA break formation was followed by the conversion of the supercoiled form into relaxed-circular and linear forms. In the concentration interval of 0-4 μм Fe (II), Fe (II)-EDTA slowed-down the formation of DNA breaks, while Fe (Il)-mimosine enhanced the rate of break formation up to several times. A conclusion is drawn that this enhancement is due to the increased affinity of the Fe (Il)-mimosine complex to DNA.
APA, Harvard, Vancouver, ISO, and other styles
43

Beyerman, H. C., L. Maat, and M. P. Hegarty. "The absolute configuration of mimosine." Recueil des Travaux Chimiques des Pays-Bas 83, no. 10 (September 2, 2010): 1078–82. http://dx.doi.org/10.1002/recl.19640831011.

Full text
APA, Harvard, Vancouver, ISO, and other styles
44

Champanerkar, Parikshit A., Vikas V. Vaidya, Sunita Shailajan, and Sasikumar N. Menon. "A sensitive, rapid and validated liquid chromatography ? tandem mass spectrometry (LC-MS-MS) method for determination of Mimosine in Mimosa pudica Linn." Natural Science 02, no. 07 (2010): 713–17. http://dx.doi.org/10.4236/ns.2010.27088.

Full text
APA, Harvard, Vancouver, ISO, and other styles
45

Mosca, P. J., P. A. Dijkwel, and J. L. Hamlin. "The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells." Molecular and Cellular Biology 12, no. 10 (October 1992): 4375–83. http://dx.doi.org/10.1128/mcb.12.10.4375.

Full text
Abstract:
An understanding of replication initiation in mammalian cells has been hampered by the lack of mutations and/or inhibitors that arrest cells just prior to entry into the S period. The plant amino acid mimosine has recently been suggested to inhibit cells at a regulatory step in late G1. We have examined the effects of mimosine on cell cycle traverse in the mimosine [corrected]-resistant CHO cell line CHOC 400. When administered to cultures for 14 h after reversal of a G0 block, the drug appears to arrest the population at the G1/S boundary, and upon its removal cells enter the S phase in a synchronous wave. However, when methotrexate is administered to an actively dividing asynchronous culture, cells are arrested not only at the G1/S interface but also in early and middle S phase. Most interestingly, two-dimensional gel analysis of replication intermediates in the initiation locus of the amplified dihydrofolate reductase domain suggests that mimosine may actually inhibit initiation. Thus, this drug represents a new class of inhibitors that may open a window on regulatory events occurring at individual origins of replication.
APA, Harvard, Vancouver, ISO, and other styles
46

Mosca, P. J., P. A. Dijkwel, and J. L. Hamlin. "The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells." Molecular and Cellular Biology 12, no. 10 (October 1992): 4375–83. http://dx.doi.org/10.1128/mcb.12.10.4375-4383.1992.

Full text
Abstract:
An understanding of replication initiation in mammalian cells has been hampered by the lack of mutations and/or inhibitors that arrest cells just prior to entry into the S period. The plant amino acid mimosine has recently been suggested to inhibit cells at a regulatory step in late G1. We have examined the effects of mimosine on cell cycle traverse in the mimosine [corrected]-resistant CHO cell line CHOC 400. When administered to cultures for 14 h after reversal of a G0 block, the drug appears to arrest the population at the G1/S boundary, and upon its removal cells enter the S phase in a synchronous wave. However, when methotrexate is administered to an actively dividing asynchronous culture, cells are arrested not only at the G1/S interface but also in early and middle S phase. Most interestingly, two-dimensional gel analysis of replication intermediates in the initiation locus of the amplified dihydrofolate reductase domain suggests that mimosine may actually inhibit initiation. Thus, this drug represents a new class of inhibitors that may open a window on regulatory events occurring at individual origins of replication.
APA, Harvard, Vancouver, ISO, and other styles
47

Cannon, Jennifer D., Srinivas V. Seekallu, Catherine A. VandeVoort, and Charles L. Chaffin. "Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cells." American Journal of Physiology-Endocrinology and Metabolism 296, no. 6 (June 2009): E1392—E1399. http://dx.doi.org/10.1152/ajpendo.90965.2008.

Full text
Abstract:
During hormonally induced ovarian follicle growth, granulosa cell proliferation increases and returns to baseline prior to the administration of an ovulatory stimulus. Several key genes appear to follow a similar pattern, including the luteinizing hormone receptor (LHCGR), suggesting an association between cell cycle progression and gene expression. The expression of LHCGR mRNA in granulosa cells isolated from immature rats and treated in culture with FSH increased in a time-dependent manner, whereas administration of the cell cycle inhibitor mimosine completely suppressed expression. Although forskolin was able to induce luteinization in cells treated with mimosine, human chorionic gonadotropin had no effect, indicating the functional loss of LHCGR. The effects of mimosine on cell cycle progression and LHCGR mRNA expression were reversible within 24 h of mimosine removal. Cell cycle inhibition did not alter the stability of LHCGR mRNA, indicating that the primary effect was at the transcriptional level. To determine whether the relationship between LHCGR expression and cell cycle were relevant in vivo, immature rats were given a bolus of PMSG, followed by a second injection of either saline or PMSG 24 h later to augment levels of proliferation. The expression of LHCGR mRNA was elevated in the ovaries of animals receiving a supplement of PMSG. Mimosine also blocked cell cycle progression and LHCGR mRNA expression in macaque granulosa cells isolated following controlled ovarian stimulation cycles and in two different mouse Leydig tumor lines. These data collectively indicate that LHCGR mRNA is expressed as a function of the passage of cells across the G1-S phase boundary.
APA, Harvard, Vancouver, ISO, and other styles
48

Anitha, R., S. Jayavelu, and K. Murugesan. "Antidermatophytic and bacterial activity of mimosine." Phytotherapy Research 19, no. 11 (2005): 992–93. http://dx.doi.org/10.1002/ptr.1761.

Full text
APA, Harvard, Vancouver, ISO, and other styles
49

Frydas, S., N. Papaioannou, M. Papazachariadou, M. Xatzistilianou, I. Vlemmas, D. Merlitti, M. L. Castellani, C. Schiavone, A. Tulli, and M. Di Gioacchino. "A Spectrum of Antibody (IgG, IgG1, IgM) Response in Mice Infected with Trichinella Spiralis Treated with L-Mimosine." International Journal of Immunopathology and Pharmacology 15, no. 1 (January 2002): 19–26. http://dx.doi.org/10.1177/039463200201500103.

Full text
Abstract:
The purpose of this study was to demonstrate the anti-inflammatory effects of L-mimosine on chronic inflammation, by investigating its effect on the immunological response of BALB/c mice infected with the nematode parasite Trichinella spiralis. Specific anti-parasite immunoglobulins (IgG, IgG1 and IgM) were detected by the ELISA method in the serum of both the treated and the untreated animals at different periods of time for 60 days post infection. Two groups consisting of 18 mice each were used. The mice were 6 weeks of age. Both groups were infected with 220 larvae (L1 - T. spiralis) per os: one group was administered an intraperitoneal injection of L-mimosine (200 μg/100 ml/dose) for 27 days (the first injection started 7 days before infection) and the second group was administered an intraperitoneal injection of saline solution (100 μI/dose). Parasite specific IgG, IgG1 and IgM levels were determined in the sera of infected, untreated mice. The levels of IgG and IgG1 were increased following infection and remained elevated throughout the experimental period, while IgM was significantly decreased on the 50th day post-infection. These levels were found to be lower in the L-mimosine treated infected mice, compared to the untreated mice. The inhibition started from the 10th day and continued until the 60th day. In healthy animals, the production of immunoglobulins was not measurable. Non-infected animals treated with L-mimosine also showed no detectable anti-parasite specific immunoglobulins. The results in this study show that the course of IgG, IgG1 and IgM production in BALB/c mice infected with T. spiralis may be influenced by the administration of L-mimosine.
APA, Harvard, Vancouver, ISO, and other styles
50

Fang, Yi, Xiaofang Yu, Yong Liu, Alison J. Kriegel, Yanyan Heng, Xialian Xu, Mingyu Liang, and Xiaoqiang Ding. "miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-α activation." American Journal of Physiology-Renal Physiology 304, no. 10 (May 15, 2013): F1274—F1282. http://dx.doi.org/10.1152/ajprenal.00287.2012.

Full text
Abstract:
Treatment with l-mimosine, which activates hypoxia-inducible factor-α (HIF-α), attenuates renal tubulointerstitial injury and improves renal function in a rat remnant kidney model. The miR-29 family of microRNAs directly targets a large number of extracellular matrix genes and reduces renal interstitial fibrosis. We analyzed microRNA expression profiles in rat remnant kidneys with or without treatment with l-mimosine. The expression of miR-29c was downregulated in rat remnant kidneys compared with sham control and significantly restored by the l-mimosine treatment. In cultured human kidney epithelial HK2 cells, cobalt chloride activated HIF-α and upregulated miR-29c expression. The upregulation of miR-29c expression was significantly attenuated by knockdown of HIF-1α or HIF-2α. Downregulation of miR-29c was associated with significant increases in interstitial fibrosis, collagen type II α1 (COL2A1) protein, and tropomyosin 1α (TPM1) protein in rat remnant kidneys and in kidneys from IgA nephropathy patients. The increases in rat remnant kidneys were attenuated by the l-mimosine treatment. COL2A1 and TPM1 were confirmed to be new, direct targets of miR-29c. In conclusion, miR-29c, an antifibrotic microRNA, is upregulated by HIF-α activation. MiR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by activation of HIF-α that attenuates fibrosis.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the bibliographies on the topic 'Mimosin' for other source types:
Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography