Relevant bibliographies by topics / MIMMS

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'MIMMS'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "MIMMS"

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Lv, Yun-Kai, Xue Xiong, Fang-Fang Zhao, Meng-Zhe Li, Mian Wang, and Xiao-Yang Li. "Preparation of Magnetic Surface-Imprinted Polymer Microspheres with Hydrophilic External Layers for Selective Extraction of Fluoroquinolones from Eggs." Australian Journal of Chemistry 70, no. 3 (2017): 237. http://dx.doi.org/10.1071/ch16250.

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A novel method of one-pot covalently grafting a hydrophilic organic polymer imprinted layer on the surface of magnetic microspheres was developed for the preparation of restricted access materials–molecularly imprinted magnetic microspheres (RAM-MIMMs) with water compatibility and ability to exclude biomacromolecules and selectively enrich analytes. The magnetic nanoparticles were coated with silica gel, modified with vinyl groups, polymerized with the template (enrofloxacin), functional monomer (glycidyl methacrylate, methacrylic acid), and cross-linking agent (ethylene glycol dimethacrylate) in chloroform, and then the hydrophilic surface was formed by a ring-opening reaction. The RAM-MIMMs were characterized by transmission electron microscopy, FT-IR spectroscopy, and adsorption experiments and demonstrated average diameters around 400 nm and a coating thickness in the range of 50 nm. They exhibited high selectivity of the imprinted cavities and hydrophilicity of the external surface with water compatibility and exclusion of biomacromolecules. The RAM-MIMMs were used for the magnetic dispersion microextraction of fluoroquinolones from egg samples with satisfactory results.
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Kaji, Arito, Hiromasa Yamamoto, and Naoto Morimura. "Revised Hospital-MIMMS Course for Japan." Prehospital and Disaster Medicine 34, s1 (May 2019): s165. http://dx.doi.org/10.1017/s1049023x19003753.

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Introduction:HMIMMS (Major Incident Medical Management and Support: The Practical Approach in the Hospital) has been introduced by ALSG (Advanced Life Support Group, Manchester, UK) and developed for many countries for preparing to accept huge numbers of casualties at a hospital during major incidents. The original HMIMMS course has been held in Japan since 2007, produced over 1,200 providers. Japan has a crucial history of natural disasters, earthquakes, tsunamis, and typhoons often resulting in extensive damages to infrastructure and communications.Aim:The MIMMS-JAPAN and the Japanese Association for Disaster Medicine have joined to plan to revise the original HMIMMS course from the point of view of the difference of the type of disaster.Method:By the permission of ALSG, two subjects were added “Hospital Evacuation” and “Business Continuity Plan” as lectures, workshops, and tabletops to the original HMIMMS course. Before attending the course, students were required to watch e-learning for deeper understanding and time-saving. Total program was organized into two days.Results:Main points of modification are to: 1.Replace a system peculiar to the UK with a Japanese system.2.Add unique contents of a Japanese disaster.3.Add the important subjects especially in Japan.4.Modify the presentation slides to understand easily for Japanese students. But the fundamental concept that hospital functions upon ‘CSCATTT’ is strictly preserved.Discussion:Newly revised HMIMMS course will start in 2019 for Japanese learners. Many reflections must be accumulated and further revisions will continue.
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Vermeulen, Lisa, and Dianne Stephens. "Regional Engagement Program: Supporting Local Leadership and Building Local Skills and Knowledge in Order to Develop a Systematic Approach to Disaster Medical Management." Prehospital and Disaster Medicine 34, s1 (May 2019): s162—s163. http://dx.doi.org/10.1017/s1049023x19003698.

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Introduction:One of the key components in any effective disaster response is the capacity of local communities to respond in a timely and efficient manner. Over the last 3 years, the National Critical Care and Trauma Response Centre in Darwin has been involved in building regional capacity across the Asia-Pacific, supporting local leadership and building local skills and knowledge in order to develop a systematic approach to disaster medical management.Aim:This presentation is to describe the Regional Engagement Program, its strengths, weaknesses, and outcomes.Methods:We will describe the background to the program, the process for regional engagement and the Results of our evaluation. The program used the Major Incident Medical Management Systems (MIMMS) approach which was delivered in-country and included identifying and using local personnel to deliver the program. The program was conducted across the region in Myanmar, Fiji, Tonga, Vanuatu, Samoa, Timor, and Indonesia. Initially the courses were run by personnel from Australia but through engagement with local Ministries of Health and collaboration with identified key stakeholders, we have been able to build local faculty to ensure sustainability and local ownership.Results:Thirty-six personnel have been trained across four countries. Thirty-six candidates are now instructors, with a further 36 identified for future development as instructors. The evaluation illustrates the long-term partnerships that have been developed and the ongoing capacity development of key regional partners.Discussion:The Regional Engagement program demonstrates that prolonged engagement with key regional stakeholders and adequate and sustained mentoring will successfully build local capacity to the level needed to mount a successful response to a disaster. Personnel trained through this program helped guide the response to the Lombok earthquake and in Fiji, a MIMMS Team Member training program was conducted with minimal external support.
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Wachira, Benjamin W., Ramadhani O. Abdalla, and Lee A. Wallis. "Westgate Shootings: An Emergency Department Approach to a Mass-casualty Incident." Prehospital and Disaster Medicine 29, no. 5 (September 10, 2014): 538–41. http://dx.doi.org/10.1017/s1049023x1400096x.

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AbstractAt approximately 12:30 pm on Saturday September 21, 2013, armed assailants attacked the upscale Westgate shopping mall in the Westlands area of Nairobi, Kenya. Using the seven key Major Incident Medical Management and Support (MIMMS) principles, command, safety, communication, assessment, triage, treatment, and transport, the Aga Khan University Hospital, Nairobi (AKUH,N) emergency department (ED) successfully coordinated the reception and care of all the casualties brought to the hospital.This report describes the AKUH,N ED response to the first civilian mass-casualty shooting incident in Kenya, with the hope of informing the development and implementation of mass-casualty emergency preparedness plans by other EDs and hospitals in Kenya, appropriate for the local health care system.WachiraBW, AbdallaRO, WallisLA. Westgate shootings: an emergency department approach to a mass-casualty incident. Prehosp Disaster Med. 2014;29(5):1-4.
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Logan, Peter, Carissa Oh, and Andrew Pearce. "The Introduction of Hospital MIMMS, A United Kingdom Based Hospital Mass Casualty Response Course to Australia: Needs, Issues and Solutions." Prehospital and Disaster Medicine 32, S1 (April 2017): S72. http://dx.doi.org/10.1017/s1049023x17001923.

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Sammut, John, Denys Cato, and Tony Homer. "Major Incident Medical Management and Support (MIMMS): A practical, multiple casualty, disaster-site training course for all Australian health care personnel." Emergency Medicine Australasia 13, no. 2 (June 2001): 174–80. http://dx.doi.org/10.1046/j.1442-2026.2001.00206.x.

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Dryden, M. "Medical microbiology Mimms C, Playfair J, Roitt I, Wakelin D, Williams R., Second edition; 1998. Mosby £29.95. ISBN 0-7234-2781-X." Journal of Hospital Infection 40, no. 4 (December 1998): 330–31. http://dx.doi.org/10.1016/s0195-6701(98)90317-6.

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Xiong, Yan, Qing Wang, Ming Duan, Jing Xu, Jie Chen, and Shenwen Fang. "Preparation of Molecularly Imprinted Microspheres as Biomimetic Recognition Material for In Situ Adsorption and Selective Chemiluminescence Determination of Bisphenol A." Polymers 10, no. 7 (July 16, 2018): 780. http://dx.doi.org/10.3390/polym10070780.

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Bisphenol A (BPA) is an endocrine disrupter in environments which can induce abnormal differentiation of reproductive organs by interfering with the action of endogenous gonadal steroid hormones. In this work, the bisphenol A (BPA) molecularly-imprinted microspheres (MIMS) were prepared and used as biomimetic recognition material for in situ adsorption and selective chemiluminescence (CL) determination of BPA. Through non-covalent interaction, the BPA-MIMS was successfully prepared by Pickering emulsion polymerization using a BPA template, 4-vinylpyridine (4-VP) monomer, ethylene glycol dimethacrylate (EGDMA) cross-linker, and a SiO2 dispersion agent. The characterization of scanning electron microscopy (SEM) and energy-disperse spectroscopy (EDS) showed that the obtained MIMS possessed a regular spherical shape and narrow diameter distribution (25–30 μm). The binding experiment indicated BPA could be adsorbed in situ on the MIMS-packing cell with an apparent maximum amount Qmax of 677.3 μg g−1. Then BPA could be selectively detected by its sensitive inhibition effect on the CL reaction between luminol and periodate (KIO4), and the inhibition mechanism was discussed to reveal the CL reaction process. The CL intensity was linear to BPA concentrations in two ranges, respectively from 0.5 to 1.5 μg mL−1 with a detection limit of 8.0 ng mL−1 (3σ), and from 1.5 to 15 μg mL−1 with a limit of detection (LOD) of 80 ng mL−1 (3σ). The BPA-MIPMS showed excellent selectivity for BPA adsorption and the proposed CL method has been successfully applied to BPA determination in environmental water samples.
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Styrwoldt, E. "(P1-37) Over and Undertriage in Simulation Exercises." Prehospital and Disaster Medicine 26, S1 (May 2011): s110. http://dx.doi.org/10.1017/s1049023x11003694.

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Over and undertriage in simulation exercises Introduction The first healthcare personnel arriving at the scene of an accident or major incident is often an ambulance crew. It is therefore of importance that they are familiar with, and can practice triage during situations were there is a lack of resources. Overtriage, when a casualty is given a priority higher than motivated, may lead to inadequate use of resources, while undertriage can be seen as a risk for medical errors. There is a consensus that up to 50% overtriage is accepted in order to have an undertriage, which is less than 5%. The aim of this study was to increase knowledge regarding prehospital personnel's triage during standardized simulation exercises.Material and Method76 standardized simulation exercises where the triage of casualties was evaluated. The exercises were part of a training program for medical command and control at scene. The students trained were all professional ambulance crew. The scenario was a fire at a football stand with 50 causalities. All in all 3800 (76 x 50) triages were performed. The simulation system used was Emergo Train System. Prior to the exercises an expert group had triaged the causalities according to the MIMMS system (sieve). Of the 50 patients 15 were triaged as T1 by the expert group and the rest were not.ResultsOf the 3800 triages 37% (n = 410) were classified as undertriage and 13% (n = 134) as overtriage. The most frequently undertriage casualties had an airway and/or breathing problem that were not observed. The most frequently overtriage casualties had a burn injury involving 30% of body surface area or unconscious casualties.ConclusionsTriage in this simulation setting did not meet acceptable standards. More triage training for ambulance crew may improve outcome. More studies are needed regarding simulation exercises as a tool for evaluating results of triage.
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Backman, Ruth, Philip Weber, Alice M. Turner, Mark Lee, and Ian Litchfield. "Assessing the extent of drug interactions among patients with multimorbidity in primary and secondary care in the West Midlands (UK): a study protocol for the Mixed Methods Multimorbidity Study (MiMMS)." BMJ Open 7, no. 9 (September 2017): e016713. http://dx.doi.org/10.1136/bmjopen-2017-016713.

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IntroductionThe numbers of patients with three or more chronic conditions (multimorbidity) are increasing, and will rise to 2.9 million by 2018 in the UK alone. Currently in the UK, conditions are mainly managed using over 250 sets of single-condition guidance, which has the potential to generate conflicting recommendations for lifestyle and concurrent medication for individual patients with more than one condition. To address some of these issues, we are developing a new computer-based tool to help manage these patients more effectively. For this tool to be applicable and relevant to current practice, we must first better understand how existing patients with multimorbidity are being managed, particularly relating to concerns over prescribing and potential polypharmacy.Methods and analysisUp to four secondary care centres, two community pharmacies and between four and eight primary care centres in the West Midlands will be recruited. Interviewees will be purposively sampled from these sites, up to a maximum of 30. In this mixed methods study, we will perform a dual framework analysis on the qualitative data; the first analysis will use the Theoretical Domains Framework to assess barriers and enablers for healthcare professionals around the management of multimorbid patients; the second analysis will use Normalisation Process Theory to understand how interventions are currently being successfully implemented in both settings. We will also extract quantitative anonymised patient data from primary care to determine the extent of polypharmacy currently present for patients with multimorbidity in the West Midlands.DiscussionWe aim to combine these data so that we can build a useful, fully implementable tool which addresses the barriers most amenable to change within both primary and secondary care contexts.Ethics and disseminationFavourable ethical approval has been granted by The University of Birmingham Research Ethics Committee (ERN_16–0074) on 17 May 2016. Our work will be disseminated through peer-reviewed literature, trade journals and conferences. We will also use the dedicated web page hosted by the University to serve as a central point of contact and as a repository of our findings. We aim to produce a minimum of three articles from this work to contribute to the international scientific literature.Protocol registration numberNIHR Clinical Research Network Portfolio Registration CPMS ID 30613.
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Dissertations / Theses on the topic "MIMMS"

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Cato, Denys, and mikewood@deakin edu au. "An examination of the 'all hazards' approach to disaster management as applied to field disaster management and pre-hospital care in Australia." Deakin University. School of Health Sciences, 2002. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20051017.140738.

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Disasters, emergencies, incidents, and major incidents - they all come back to the same thing regardless of what they are called. The common denominator is that there is loss of life, injury to people and animals and damage and destruction of property. The management of such events relies on four phases: 1. Prevention 2. Preparation 3. Response 4. Recovery Each of these phases is managed in a different way and often by different teams. Here, concentration has been given to phases 2 and 3, with particular emphasis on phase 3, Response. The words used to describe such events are often related to legislation. The terminology is detailed later. However, whatever the description, whenever prevention is not possible, or fails, then the need is to respond. Response is always better when the responders are prepared. Training is a major part of response preparation and this book is designed to assist those in the health industry who need to be ready when something happens. One of the training packages for responders is the Major Incident Medical Management and Support (MIMMS) Course and this work was designed to supplement the manual prepared by Hodgetts and Macway-Jones(87) in the UK. Included is what the health services responder, who may be sent to an event in which the main concern is trauma, should know. Concentration is on the initial response and does not deal in any detail with hospital reaction, the public health aspects, or the mental health support that provides psychological help to victims and responders, and which are also essential parts of disaster management. People, in times of disaster, have always been quick to offer assistance. It is now well recognised however, that the 'enthusiastic amateur', whilst being a well meaning volunteer, isn't always what is needed. All too often such people have made things worse and have sometimes ended up as victims themselves. There is a place now for volunteers and there probably always will be. The big difference is that these people must be well informed, well trained and well practiced if they are to be effective. Fortunately such people and organisations do exist. Without the work of the St John Ambulance, the State Emergency Service, the Rural Fire Service the Red Cross and the Volunteer Rescue Association, to mention only a few, our response to disasters would be far less effective. There is a strong history of individuals being available to help the community in times of crisis. Mostly these people were volunteers but there has also always been the need for a core of professional support. In the recent past, professional support mechanisms have been developed from lessons learned, particularly to situations that need a rapid and well organised response. As lessons are learned from an analysis of events, philosophy and methods have changed. Our present system is not perfect and perhaps never will be. The need for an 'all-hazards approach' makes detailed planning very difficult and so there will probably always be criticisms about the way an event was handled. Hindsight is a wonderful thing, provided we learn from it. That means that this text is certainly not the 'last word' and revisions as we learn from experience will be inevitable. Because the author works primarily in New South Wales, many of the explanations and examples are specific to that state. In Australia disaster response is a State, rather than a Commonwealth, responsibility and consequently, and inevitably, there are differences in management between the states and territories within Australia. With the influence of Emergency Management Australia, these differences are being reduced. This means that across state and territory boundaries, assistance is common and interstate teams can be deployed and assimilated into the response rapidly, safely, effectively and with minimum explanation. This text sets out to increase the understanding of what is required, what is in place and how the processes of response are managed. By way of introduction and background, examples are given of those situations that have occurred, or could happen. Man Made Disasters has been divided into two distinct sections. Those which are related to structures or transport and those related directly to people. The first section, Chapter 3, includes: • Transport accidents involving land, rail, sea or air vehicles. • Collapse of buildings for reasons other than earthquakes or storms. • Industrial accidents, including the release of hazardous substances and nuclear events. A second section dealing with the consequences of the direct actions of people is separated as Chapter 4, entitled 'People Disasters'. Included are: • Crowd incidents involving sports and entertainment venues. • Terrorism From Chapter 4 on, the emphasis is on the Response phase and deals with organisation and response techniques in detail. Finally there is a section on terminology and abbreviations. An appendix details a typical disaster pack content. War, the greatest of all man made disasters is not considered in this text.
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El-Hajjar, Mohammed H. "Near-capacity MIMOs using iterative detection." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/64487/.

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In this thesis, Multiple-Input Multiple-Output (MIMO) techniques designed for transmission over narrowband Rayleigh fading channels are investigated. Specifically, in order to provide a diversity gain while eliminating the complexity of MIMO channel estimation, a Differential Space-Time Spreading (DSTS) scheme is designed that employs non-coherent detection. Additionally, in order to maximise the coding advantage of DSTS, it is combined with Sphere Packing (SP) modulation. The related capacity analysis shows that the DSTS-SP scheme exhibits a higher capacity than its counterpart dispensing with SP. Furthermore, in order to attain additional performance gains, the DSTS system invokes iterative detection, where the outer code is constituted by a Recursive Systematic Convolutional (RSC) code, while the inner code is a SP demapper in one of the prototype systems investigated, while the other scheme employs a Unity Rate Code (URC) as its inner code in order to eliminate the error floor exhibited by the system dispensing with URC. EXIT charts are used to analyse the convergence behaviour of the iteratively detected schemes and a novel technique is proposed for computing the maximum achievable rate of the system based on EXIT charts. Explicitly, the four-antenna-aided DSTSSP system employing no URC precoding attains a coding gain of 12 dB at a BER of 10−5 and performs within 1.82 dB from the maximum achievable rate limit. By contrast, the URC aided precoded system operates within 0.92 dB from the same limit. On the other hand, in order to maximise the DSTS system’s throughput, an adaptive DSTSSP scheme is proposed that exploits the advantages of differential encoding, iterative decoding as well as SP modulation. The achievable integrity and bit rate enhancements of the system are determined by the following factors: the specific MIMO configuration used for transmitting data from the four antennas, the spreading factor used and the RSC encoder’s code rate. Additionally, multi-functional MIMO techniques are designed to provide diversity gains, multiplexing gains and beamforming gains by combining the benefits of space-time codes, VBLAST and beamforming. First, a system employing Nt=4 transmit Antenna Arrays (AA) with LAA number of elements per AA and Nr=4 receive antennas is proposed, which is referred to as a Layered Steered Space-Time Code (LSSTC). Three iteratively detected near-capacity LSSTC-SP receiver structures are proposed, which differ in the number of inner iterations employed between the inner decoder and the SP demapper as well as in the choice of the outer code, which is either an RSC code or an Irregular Convolutional Code (IrCC). The three systems are capable of operating within 0.9, 0.4 and 0.6 dB from the maximum achievable rate limit of the system. A comparison between the three iteratively-detected schemes reveals that a carefully designed two-stage iterative detection scheme is capable of operating sufficiently close to capacity at a lower complexity, when compared to a three-stage system employing a RSC or a two-stage system using an IrCC as an outer code. On the other hand, in order to allow the LSSTC scheme to employ less receive antennas than transmit antennas, while still accommodating multiple users, a Layered Steered Space-Time Spreading (LSSTS) scheme is proposed that combines the benefits of space-time spreading, V-BLAST, beamforming and generalised MC DS-CDMA. Furthermore, iteratively detected LSSTS schemes are presented and an LLR post-processing technique is proposed in order to improve the attainable performance of the iteratively detected LSSTS system. Finally, a distributed turbo coding scheme is proposed that combines the benefits of turbo coding and cooperative communication, where iterative detection is employed by exchanging extrinsic information between the decoders of different single-antenna-aided users. Specifically, the effect of the errors induced in the first phase of cooperation, where the two users exchange their data, on the performance of the uplink in studied, while considering different fading channel characteristics.
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Belghiti, Touria. "Synthèse de glycophanes mimes de cyclodextrines." Nancy 1, 2002. http://www.theses.fr/2002NAN10011.

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De nouveaux glycophanes ont été construits par le biais de la réaction de Ferrier, la réaction de Williamson et la réaction de couplage oxydant. La préparation originale de différents disaccharides 1,1' a été réalisée avec de bons rendements par double condensation de diols symétriques commerciaux sur le D-glucal. La réaction de Glaser s'est imposée pour la construction des cycles une fois un éther de propargyl installé sélectivement sur C-4 par transfert de phase après que la fonction alcool primaire ait été protégée par réaction avec le chlorure de trityle plus sélectif que les réactifs silylés (TBDMSCl et TBDPSCl). Deux stratégies de cyclisation ont été développées : la méthode directe, qui conduit aussi à une dimérisation par intracyclisation, et une méthode indirecte, dénommée " pas à pas ", qui permet d'orienter la cyclisation vers l'obtention de tétrasaccharides (et d'oligomères de plus grande taille) en se dispensant de protections orthogonales. La réduction ménagée de la double liaison sur le sucre a permis la synthèse de 2 glycophanes en quantités égales : un tétrasaccharide cyclique et un très remarquable octasaccharide cyclique, dimère du premier. Après isolement, le glycophane incorporant 4 résidus sucre a été partiellement réduit par hydrogénation catalytique ménagée. La plupart de ces macrocycles ont pu être pleinement caractérisés sans ambigui͏̈té à l'aide de la spectrométrie de masse MALDI-TOF.
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Probin, Jamie. "How ideal is the Mimas-Tethys resonance?" Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367166.

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Halie, Delphine. "Synthèse diastéréosélective de mimes du peptide RGD." Paris 5, 2006. http://www.theses.fr/2006PA05P639.

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Moris, Marc-Antoine Schlewer Gilbert. "Synthèse d'analogues de phosphates d'inositol mimes de l'adénophostine." Strasbourg : Université Louis Pasteur, 2006. http://eprints-scd-ulp.u-strasbg.fr:8080/505/01/MORIS2006.pdf.

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Moris, Marc-Antoine. "Synthèse d'analogues de phosphates d'inositol mimes de l'adénophostine." Strasbourg 1, 2006. https://publication-theses.unistra.fr/public/theses_doctorat/2006/MORIS_Marc-Antoine_2006.pdf.

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L'objet de ce travail est la synthèse et l'étude des propriétés pharmacologiques d'analogues de l'Ins(1,4,5)P3 mimes de l'adénophostine. Le rôle et les interactions biologiques de l'Ins(1,4,5)P3 et de l'adénophostine, de même que leurs relations structure/activité sont rappelés. Le potentiel thérapeutique lié au cycle des phosphates d'inositol est mentionné. L'orthoester du myo-inositol, inversant la conformation chaise de l'inositol, permet d'activer la position 2 ainsi équatoriale et d'introduire les espaceurs. Ce travail décrit une voie de synthèse innovante d'analogues de l'Ins(1,4,5)P3 chimères de l'adénophostine possèdant un bras butylique purinylé. Les propriétés pharmacologiques de nos analogues atteignent celles de l'Ins(1,4,5)P3. Ceci est plus perceptible si nous considérons le fait que nos composés sont racémiques. Ces résultats confirment le pharmacophore indiquant que la position 2 tolère la substitution, tel que l'indique le modèle de pharmacophore communément admis
The aim of this work was the synthesis and the study of the pharmacological properties of adenophostin mimes Ins(1,4,5)P3 analogues. The biological function and targets of Ins(1,4,5)P3 and adenophostin as well as their structure/activity relationships are reported. The therapeutic potential linked to the inositol phosphates cycle is mentioned. The use of a myo-inositol orthoester, inverting the inositol chair conformation, permitted the activation of the position 2 and the introduction of the lateral chains. This work describes an innovative synthetic pathway of adenophostin mimes Ins(1,4,5)P3 analogues possessing a purinylated butylic arm. The pharmacological properties of our analogues are matching those of the Ins(1,4,5)P3. This is more noticeable if we consider the fact that our compounds are racemic. These results support those of previous studies indicating that the position 2 tolerates some substitution, as indicated by the commonly admitted pharmacophore model
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Zagiel, Benjamin. "Chimie combinatoire dynamique pour l’identification de mimes de protéines." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS520.

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Les interactions protéines protéines (PPI) constituent des cibles thérapeutiques de premier intérêt mais la complexité des interfaces impliquées dans ces interactions rend le développement d’inhibiteurs de PPI difficile. Les peptides présentent un grand potentiel pour cibler les PPI mais sans structure 3D définie, ils ne présentent généralement pas d’affinité. Les peptides contraints dans une conformation contrôlée ou scaffolds constituent une solution efficace mais leur conception requiert une compréhension significative du complexe protéique à l’échelle de l’épitope. Ce travail a pour but de développer une approche de chimie combinatoire dynamique (DCC) pour la fonctionnalisation de scaffolds peptidiques. Cette approche permettrait de générer des librairies dynamiques par des réactions réversibles équilibrées entre des blocs moléculaires. Ces systèmes dynamiques étant sensibles aux stimuli, il est alors possible d’introduire une cible d’intérêt pour les cribler, le tout en une seule étape. Ce manuscrit présente la conception et la synthèse de blocs moléculaires et de scaffolds pour cette stratégie de DCC. La mise au point de cette méthodologie de DCC est ensuite présentée dans une approche pas à pas jusqu’à une tentative d’application à une cible d’intérêt : l’héparine. La développement d’une méthode d'analyse par spectrométrie de masse des composés générés par DCC est ensuite abordée. Enfin, l'analyse structurale des plateformes et l'influence de leur fonctionnalisation sur leur structuration est abordée
Protein protein interactions (PPI) are therapeutic targets of prime interest but the complexity of their interaction interfaces makes difficult the development of PPIs inhibitors. Peptides display great potential for targeting PPIs but without a defined 3D structure, they usually show no affinity. Constrained peptides with a controlled conformation or scaffolds constitute an effective solution but their design requires a significant comprehension of the protein complex at the epitope scale.This work aims at developing a dynamic combinatorial chemistry (DCC) approach to functionalize peptide scaffolds. This approach allows to generate dynamic libraries thanks to equilibrated reversible reactions between molecular building blocks. These dynamic systems being stimuli-responsive, it is therefore possible to introduce a relevant target to screen them in one step. This thesis presents the design and the synthesis of the building blocks and scaffolds for this DCC strategy. The development of the DCC methodology is then presented in a step by step approach up to an application attempt with heparin as the target. Next, the mass spectrometry method for the analysis of the DCC generated compounds and its setting up is addressed. Finally, the analysis of the peptide scaffolds structure and the influence of their functionalization on it is broached
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Manzoor, Suryyia 1984. "Materiais impressos molecularmente (MIMs) : síntese, caracterização e avaliação." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250225.

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Orientadores: Adriana Vitorino Rossi, Regina Buffon
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química
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Resumo: Este trabalho envolveu um estudo elaborado da técnica de impressão molecular para síntese, caracterização e avaliação de materiais impressos molecularmente (MIMs) para fluconazol (FLU), cafeína (CAF) e antocianinas (ACYs). O polímero de impressão molecular para FLU (FLUMIP) foi sintetizado utilizando-se ácido metacrílico (monômero funcional), etilenoglicoldimetacrilato (EGDMA) (agente reticulador) e acetonitrila em polimerização térmica. O FLUMIP foi caracterizado e aplicado como sorvente em cartuchos de extração em fase sólida (SPE). Sua capacidade de interação seletiva com o analito foi avaliada, obtendo-se alta afinidade para FLU, em comparação com análogos estruturais, com limite de detecção menor que 1,63X10 mmol/L com cromatografia de ultra alta eficiência acoplada com espectrometria de massas. Este MIP foi usado em cartuchos de SPE para extrair o analito de medicamento em cápsula, com recuperação de 91±10 % (n=9). Outro MIM obtido foi uma sílica organicamente modificada (ORMOSIL) para extração de CAF, a partir da reação de metacrilato de 3- (trimetoxisilil) propila e acetato de vinila, seguindo-se condensação e hidrólise com tetraetilortosilicato usando CAF como molécula modelo. Este ORMOLSIL foi caracterizado e testado quanto à sua eficácia de extrair CAF de amostras de café, com recuperação de 88±5 % (n=9); ele atuou como grupo seletivo com alta porcentagem de recuperação para teofilina (77 %) e teobromina (82 %). Limites de detecção e quantificação 5,14x10 e 1,71x10 mmol/L respectivamente foram obtidos com cromatografia líquida de alta eficiência. Também foi sintetizado um MIP usando rutina molécula modelo (RUTMIP), acrilamida (monômero funcional), EGDMA (agente reticulador) e tetraidrofurano por polimerização em bulk. Embora tenha sido alcançada impressão bem sucedida de rutina, confirmada pela comparação de afinidade de RUTMIP em aplicação de SPE (12 vezes maior que afinidade do polímero não impresso), não se alcançou a seletividade esperada para ACYs utilizando o RUTMIP
Abstract: This work involves an elaborative study of molecularly imprinting technique. Keeping in view its robustness and selectivity, this technique was applied for the synthesis of molecularly imprinted materials for the extraction of fluconazole (FLU), caffeine (CAF) and anthocyanins (ACYs). Molecularly imprinted polymer (MIP) for FLU (FLUMIP) was synthesized using methacrylic acid (functional monomer), ethyleneglycoldimethacrylate (crosslinker) and acetonitrile through thermal polymerization. The FLUMIP was characterized and applied as sorbent in solid phase extraction (SPE) cartridges. It was then evaluated for its ability to selectively interact with the analyte and presented an apparent affinity for FLU, which was confirmed by comparing it with structural analogues. The application of ultra high performance liquid chromatography with spectrometer mass detection, allowed a limit of detection 1.63x10 mmol/L. Furthermore, the SPE procedure was applied to extract FLU from medicine samples with recovery of 91±10 % (n=9). An organically modified silica (ORMOSIL) for CAF was also synthesized by reacting vinyl acetate and 3- (trimethoxysilyl) propyl methacrylate, followed by the condensation and hydrolysis with tetraethyl orthosilicate, using CAF as template molecule. The ORMOSIL was characterized and tested for its efficiency to extract the analyte from coffee samples and the percentage recovery of 88±5 % (n=9) was obtained. The cross reactivity studies for theophylline and theobromine showed high recovery (77 % and 82% respectively). The limit of detection and quantification, 5.14x10 and 1.71x10 mmol/L respectively, were achieved using high performance liquid chromatography. Also, a MIP for ACYs (RUTMIP) was synthesized using rutin (template molecule), EGDMA (cross linker) and tetrahydrofuran by the bulk polymerization method. A successful imprinting of rutin was attained. This can be confirmed by the high affinity of rutin for MIP (12 times greater than non imprinted polymer) during SPE procedure; however, the RUTMIP was not efficient enough to selectively extract ACYs from vegetal extracts
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Hernout, Olivier. "Mimes saccharides d'Inositol Phosphate Glycanne : synthèse et propriétés insulo-mimétiques." Nancy 1, 2005. http://www.theses.fr/2005NAN10014.

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Dans le but d'améliorer la compréhension du rôle que joue les IPG (Inositol Phosphate Glycanne) dans la signalisation de l'insuline, la synthèses de différents analogues de type O-et C-disaccharidique a été réalisée. Dans un premier temps, la synthèse de huit O-disaccharides dont les aglycones lyxose, arabinose et ribose portent un phosphate cyclique, est décrite. La deuxième partie est consacrée à la synthèses totale en treize étapes d'un C-disaccharide, portant également un phosphate cyclique. L'activité de ces composés sur la prolifération cellulaire a été mesurée sur des cellules d'adénocarcinomes de colon humain et des fibroblastes dermiques. Les effets insulino-mimétiques de ces molécules on été évalués sur la captation du glucose sur une lignée d'adipocytes
That work deals with the synthesis of O- and C-disaccharide analogues of PIG (Phosphate Inositol Glycan) in order to have a better understanding of its role in the signalisation of insulin. Firstly, th synthesis of eight O-disaccharides, in which the aglycon part (lyxose, arabinose and ribose) includes a cyclic phosphate. Secondly, we present th total synthesis in thirteen steps of C-disaccharide which also includes a cyclic phosphate. The biological activity of those compounds on the cellular growth was measured on human colon adenocarcinomae cells and on dermic fibroblasts. The insulino-mimetic effects of those compounds were evaluated on the glucose uptake in adipocytes
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Books on the topic "MIMMS"

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Carley, Simon. Hospital MIMMS in a nutshell: The practical approach in the hospital. Malden, Mass: Blackwell Pub., 2006.

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Pich, Òscar M. Mimas. Valencia: 3i4 Edicions, 2009.

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Mimus. Toronto: Annick Press, 2005.

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Pirandello, Luigi. Donna Mimma. Milano: A.Mondadori, 1994.

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Mimmo Jodice. Milano: B. Mondadori, 2013.

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Germano, Celant, ed. Mimmo Rotella. Milan: Skira, 2006.

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Thal, Lilli. Mimus: Roman. Hildesheim: Gerstenberg, 2003.

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Nazrun mimmā... Tūnis: al-Dār al-Tūnisīyah lil-Kitāb, 2015.

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Paladino, Mimmo. Mimmo Paladino. New York: Sperone Westwater Gallery, 1986.

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Privitera, Mimmo. Mimmo Privitera. Quito, Ecuador: Facultad Arquitectura y Diseño, Pontificia Universidad Católica del Ecuador, 1998.

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Book chapters on the topic "MIMMS"

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Encrenaz, Therese. "Mimas." In Encyclopedia of Astrobiology, 1590. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_998.

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Encrenaz, Therese. "Mimas." In Encyclopedia of Astrobiology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_998-3.

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Encrenaz, Therese. "Mimas." In Encyclopedia of Astrobiology, 1064. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_998.

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Zúñiga, Óscar, Alberto Olivares, and Carlos Rosas. "Octopus mimus." In Cephalopod Culture, 397–413. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8648-5_21.

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Leabhart, Thomas. "New Vaudevillians, New Mimes." In Modern and Post-Modern Mime, 122–47. London: Macmillan Education UK, 1989. http://dx.doi.org/10.1007/978-1-349-20192-1_8.

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Brooker, Joseph. "Irish Mimes: Flann O'Brien." In A Companion to Irish Literature, 176–91. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781444328066.ch40.

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Klingelhöfer, G. "The Miniaturized Spectrometer Mimos II." In Mössbauer Spectroscopy in Materials Science, 413–26. Dordrecht: Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4548-0_39.

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Horn, Cornelia B. "The Martyrdom of the Mimes." In The Harp (Volume 18), edited by Geevarghese Panicker, Rev Jacob Thekeparampil, and Abraham Kalakudi, 55–70. Piscataway, NJ, USA: Gorgias Press, 2011. http://dx.doi.org/10.31826/9781463233068-006.

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Bode, H., and M. Sauer. "Das Schimmelpenning-Feuerstein-Mims-Syndrom." In Aktuelle Neuropädiatrie 1988, 162–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74499-0_20.

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Coughlan, David. "2. Mimes and Phantoms: Don DeLillo." In Ghost Writing in Contemporary American Fiction, 31–51. London: Palgrave Macmillan UK, 2016. http://dx.doi.org/10.1057/978-1-137-41024-5_3.

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Conference papers on the topic "MIMMS"

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Choi, John, Vasily Goncharov, Jessica Kleinbart, Amy Orsborn, and Bijan Pesaran. "Monkey-MIMMS: Towards Automated Cellular Resolution Large- Scale Two-Photon Microscopy In The Awake Macaque Monkey." In 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2018. http://dx.doi.org/10.1109/embc.2018.8512994.

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Amores, J. Gabriel, Guillermo Pérez, and Pilar Manchón. "MIMUS." In the 45th Annual Meeting of the ACL. Morristown, NJ, USA: Association for Computational Linguistics, 2007. http://dx.doi.org/10.3115/1557769.1557771.

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Ghazali, Masitah, Ashok Sivaji, Idyawati Hussein, Lim Tek Yong, Murni Mahmud, and Nor Laila Md Noor. "HCI Practice at MIMOS Berhad." In CHI '15: CHI Conference on Human Factors in Computing Systems. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2776888.2780360.

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Wu, N., and L. Hanzo. "Co-located versus cooperative MIMOs." In IET Seminar on Wideband and Ultrawideband Systems and Technologies: Evaluating Current Research and Development. IET, 2008. http://dx.doi.org/10.1049/ic.2008.0681.

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Solar, Carmen Del, Guillermo Pérez, Eva Florencio, David Moral, Gabriel Amores, and Pilar Manchón. "Dynamic language change in MIMUS." In Interspeech 2007. ISCA: ISCA, 2007. http://dx.doi.org/10.21437/interspeech.2007-578.

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Perez-Castillo, R., I. Garcia-Rodriguez de Guzman, and M. Piattini. "MIMOS, System Model-Driven Migration Project." In 2013 17th European Conference on Software Maintenance and Reengineering (CSMR 2013). IEEE, 2013. http://dx.doi.org/10.1109/csmr.2013.68.

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Nawari, N. O. "BIM and MIMS: Emerging Technologies." In Architectural Engineering Conference (AEI) 2008. Reston, VA: American Society of Civil Engineers, 2008. http://dx.doi.org/10.1061/41002(328)64.

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McMurtry, Gary M., John C. Wiltshire, and Arnaud Bossuyt. "A Deep-Ocean Mass Spectrometer to Monitor Hydrocarbon Seeps and Pipelines." In ASME 2005 24th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2005. http://dx.doi.org/10.1115/omae2005-67146.

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New developments in instrumentation for ocean environmental engineering are allowing unprecedented levels of trace contaminant measurement in the deep ocean. With funding from the U.S. National Science Foundation (NSF), our engineering design team constructed a new mass spectrometer-based in situ analysis system for work in the deep ocean environment over prolonged deployment periods. Our design goals were a depth capability of up to 4,000 m water depth (400 bars hydrostatic pressure) and autonomous operation for periods of up to six months to a year, depending upon the type of external battery system used or other deployment circumstances, e.g., availability of a power cable or fuel cell power source. We chose a membrane introduction mass spectrometry (MIMS) sampling approach, which allows for dissolved gases and volatile organics introduction into the mass spectrometer vacuum system. The MIMS approach and the hydrophobic, silicon-coated membrane chosen both draw upon our previous experience with this technology in the deep ocean. The membrane has been tested to 400 bars in a series of long-term hydrostatic pressure tests, which extend the 200-bar working depth rating of this membrane by a factor of 2. Long-term deployment capability of the moderately powered, approximately 100 W system, was accomplished by power management of the embedded computer system and custom electronics with Windows-based and custom software now fully-developed and bench tested. The entire system fits within a 6.5-inch outside diameter pressure housing that is approximately five feet long. It consists of a 1 to 200 amu range quadrupole mass spectrometer equipped with Faraday and electron multiplier detectors, compact turbo-molecular and backing diaphragm vacuum pumps, internal rechargeable batteries, and internal waste vacuum chamber. Sample routing past the MIMS is accomplished by computer-controlled solenoid valves. We designed the pressure housings of both 6AL4V and type 2 titanium alloys that are rated to working depths of >4,000 m and are essentially corrosion proof over long-term deployments. We designed and integrated a fail-safe valving system for both rapid response to high-pressure MIMS failure and a pressure-switch circuit and high-pressure solenoid valve to detect and protect against slow leaks of the MIMS. To route sample waters to the MIMS-based instrument, we also designed and built a rugged plastic plenum that couples to the face of the sampler head, the latter of which consists of the MIMS inlet and a full-ocean rated thermister temperature probe with an operational range from −5 to 50°C. These instrumentation innovations will be described in the paper.
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Crassidis, Agamemnon, Wayne W. Walter, Douglas A. Carr, and Erin Long. "An Intelligent Robotic System Platform for Autonomous Mapping and Sensor Data Gathering of Non-GPS Friendly Environments." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-79140.

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This paper presents results of a novel intelligent robotic system using a re-configurable platform for autonomous mapping and sensor data gathering of non-Global Positioning System (GPS) friendly, unknown and hazardous enclosed environments such as caves, underground and underwater tunnel networks, building floors, and spaces within a collapsed building rubble field. The work developed here forms a basis for a swarm of mini/micro robotic vehicles capable of autonomous routing and control with a self-contained navigation system that does not rely on GPS information. A robotic prototype capable of autonomously mapping a floor plan (such as hallways within a building) has been developed. The robot navigates autonomously without the use of GPS and gathers absolute position information developing a 2-dimensional map of the hallway network using a novel Mini Inertial Measurement/Navigation System (MIMNS) developed at RIT. Also, enhancements to the MIMNS unit are presented for estimating attitude orientation of the robot using an accelerometer based device allowing for non-flat plane mapping using the MIMNS unit. The paper presents the concepts of the robot hardware and software, results of a 2-dimensional mapping of a flat plane, and introduces simulation results of an accelerometer based attitude orientation device.
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Tsilingeridis, Odysseas, and Alexandros Karakasidis. "MILMS: A Microservices-based Learning Management System." In 2020 IEEE International Conference on Big Data (Big Data). IEEE, 2020. http://dx.doi.org/10.1109/bigdata50022.2020.9378285.

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Reports on the topic "MIMMS"

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Ward, J. S., A. Duda, and M. W. Wanlass. A novel design for monolithic interconnected modules (MIMs) for thermophotovoltaic (TPV) power conversion. Office of Scientific and Technical Information (OSTI), June 1997. http://dx.doi.org/10.2172/486095.

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Visser, A., M. Singleton, D. Hillegonds, C. Velsko, J. Moran, and B. Esser. California GAMA Special Study: A Noble Gas Membrane Inlet Mass Spectrometry (NG-MIMS) system for water and gas samples. Office of Scientific and Technical Information (OSTI), April 2012. http://dx.doi.org/10.2172/1089999.

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Pictorial map of Mimas. US Geological Survey, 1992. http://dx.doi.org/10.3133/i2155.

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