Dissertations / Theses on the topic 'Milieu therapy'
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Kruger, Maria Elizabeth. "The play milieu at creches in Macassar." Thesis, Stellenbosch : Stellenbosch University, 2011. http://hdl.handle.net/10019.1/18025.
Full textENGLISH ABSTRACT: Play is widely acknowledged as a cornerstone of childhood development. Its significance stretches beyond developing cognitive abilities and school readiness to the development of social skills, emotional expression and well-being. The milieu, or environment, is recognized as highly influential with regards to occupational performance; the play environment is therefore also of great importance to child development. However, there is a lack of knowledge regarding the assessment of this play environment, especially in a developing country context. This study therefore focuses on the play environment at South African crèches, specifically with regards to assessing the environmental factors impacting children’s play, namely play space, play objects, play time and play mates (including caregivers). The National Guidelines of ECD Services in South Africa had already set standards relating to play space, play time and caregiver ratio’s at crèches. Criteria for play objects were established as part of this study through an extensive literature review. These criteria were then applied in a quantitative, cross-sectional descriptive survey at registered crèches in Macassar, a community in the Cape Flats outside Cape Town. The survey results indicated that crèches complied to play space and play time regulations, but that not all crèches complied with the regulations regarding caregiver-child ratio’s and play object adequacy. The crèches especially lacked in gross motor play objects. These findings emphasize the importance of establishing practical criteria and guidelines for all aspects of the play environment and enforcing those standards at day care crèches. The study also provides a useful framework for measuring the adequacy of the play environment at South African crèches.
AFRIKAANSE OPSOMMING: Spel is ‘n belangrike hoeksteen in kinderontwikkeling en het ‘n noemenswaardige impak op kognitiewe ontwikkeling, skoolgereedheid, die ontwikkeling van sosiale vaardighede, uitdrukking van emosies en algemene welstand. Die milieu, of omgewing, word wyd aangeslaan vir die invloed wat dit op arbeidsverrigting uitoefen en die spelomgewing is daarom belangrik. Daar is egter ‘n tekort in kennis aangaande die spel omgewing, veral in die konteks van ‘n ontwikkelende land soos Suid-Afrika. Hierdie studie bestudeer dus die spel omgewing in Suid-Afrikaanse dagsorgsentrums. Speel-spasie, speeltyd, speelgoed en speel-maats vorm saam die omgewingsfaktore wat op die spel omgewing impakteer en die studie fokus dus op hierdie vier faktore. Die Nasionale Riglyne vir Voorskoolse Kinder Ontwikkeling in Suid Afrika het reeds standaarde gestel ten opsigte van die vewagte fisiese spasie, speeltyd en die getal kinders tot versorgers (versorger-kind verhouding) by Suid Afrikaanse dagsorg sentrums. Kriteria wat meet of daar voldoende speelgoed beskikbaar is vir kinders se optimale ontwikkeling is na aanleiding van ‘n literatuurstudie ontwikkel. Hierdie kriteria, tesame met die kriteria wat deur die Nasionale Riglyne gestel is, is gebruik om die spelomgewing by dagsorg-sentrums in die Macassar gemeenskap op die Kaapse Vlaktes net buite Kaapstad te meet d.m.v ‘n beskrywende opname. Volgens die sensus resultate voldoen die dagsorgsentrums wel aan kriteria ten opsigte van fisiese spasie en beplande speeltyd, maar ontbreek hulle ten opsigte van die versorger-kind verhouding. Die resultate dui ook aan dat al die dagsorg-sentrums nie voldoende speelgoed gehad het om die volle spektrum van kinderontwikkeling te dek nie. Hulle het veral ontbreek in speelgoed vir grof-motoriese spel. Die studie beklemtoon die belang van praktiese en spesifieke riglyne en standaarde sowel as die implementering van hierdie standaarde. Die studie verskaf ook ‘n raamwerk wat gebruik kan word in die assesering van die spel omgewing in ‘n ontwikkelende konteks, sowel as om toekomstige intervensies te lei.
Johnson, Catherine. "The effect of milieu therapy on personality and clinical symptom variables." Master's thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/13478.
Full textThe present exploratory study was conducted in Ward G22, a milieu therapy unit at Cape Town's Groote Schuur Hospital. It considers aspects of the unit's selection process, as well as particular treatment-related considerations, using a self-report questionnaire, the revised Millon Clinical Multiaxial Inventory (MCMI-II). The MCMI-II provided information about clinical symptoms and personality styles, which was used to investigate what change may be measured in patients after a 12-week stay in G22. On the strength of this information, the study sought to make suggestions as to what aspects of patient difficulties are most amenable or resistant to the unit's intervention. Lastly, it intended to make recommendations on the value of the routine use of the MCMI-II in assessing patients for admission, and in evaluating therapeutic change.
Cannaday, Austin M. "Effectiveness of DBT in the Milieu regarding Increased Therapy Progress with At-Risk Adolescents." Thesis, Prescott College, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1605543.
Full textThis research aims to provide evidence that will serve to better the quality of treatment in residential care settings for the at-risk adolescent population. Because of the various factors associated with iatrogenic effects in residential care settings and because of the impact that the developmental stage of adolescence has on later adulthood, attempts to increase this treatment quality type becomes salient. Contemporarily, dialectical behavioral therapy is utilized in residential care settings with the at-risk adolescent population and has research supporting its’ efficacy. Although dialectical behavioral therapy is utilized in this context and has demonstrated effective, it is often only provided in therapy and not in the milieu. Because of the quantity of time clients in residential care settings spend in the milieu with milieu staff, these experiences likely influence their overall therapy progress. Therefore, this research hypothesizes that dialectical behavioral therapy’s use in the milieu in addition to therapy will increase overall therapy progress for the client population than if treatment as usual were to proceed. This research was conducted in a residential care setting for at-risk adolescents and collected data during a treatment as usual assessment period; provided the intervention of training milieu staff in dialectical behavioral therapy theory, strategies, and adolescent adaptations; and collected data during a dialectical behavioral therapy treatment assessment period. Concluding is a statistical analysis of the measurable changes between assessment periods, an interpretation of the results, a discussion regarding generalization of the findings, limitations, and future considerations.
Shirelele, T. I. "Mbangu eka tsalwa ra i vutomi hi C.M. Lubisi na ra xona hi xihi? hi D.R. Maluleke." Thesis, University of Limpopo, 2011. http://hdl.handle.net/10386/2379.
Full textThis study is to conduct a detailed study of milieu in a number of Xitsonga novels in I Vutomi by Lubis CM and Xona hi Xihi? by DR Maluleke. This study also emphasizes on how the characters are depicted in rural areas and urban places. Lubisi and Maluleke are able to enlighten the community about the importance of establishing the distinct relationship between space and time. The first chapter is a general introduction that outlines and provides background of the study. Milieu as well as its manifestation in I Vutomi and Xona hi Xihi? is discussed in the second chapter. The third chapter deals with characterization. In the fourth chapter, the main theme of the novels is critically examined. The fifth chapter is a brief overview of the first four chapters. It also summarizes the findings of the research and provides recommendations.
Lipusch, James T. "An exploration of influences of staff responses to adolescents on a twenty-four hour treatment milieu with special emphasis on self psychology /." Click here for text online. The Institute of Clinical Social Work Dissertations website, 1989. http://www.icsw.edu/_dissertations/lipusch_1989.pdf.
Full textA dissertation submitted to the faculty of the Institute of Clinical Social Work in partial fulfillment for the degree of Doctor of Philosophy.
Fortune, Tracy. "Establishing an occupational milieu in aged mental health units an occupational ethnography /." Connect to full text, 2002. http://hdl.handle.net/2123/5458.
Full textTitle from title screen (viewed Oct. 26, 2009) Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Discipline of Surgery, Faculty of Health Sciences. Degree awarded 2003; thesis submitted 2002. Includes bibliography. Also available in print form.
Ahmed, Nazeema. "An evaluation of the psychotherapeutic milieu therapy programme of the William Slater Centre for Adolescents and Young Adults." Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/13458.
Full textIn recent years there has been increasing recognition of the turmoil of the adolescent developmental period. This has primarily been the result of research demonstrating high morbidity, and at times mortality, for this age group. With the acknowledgement of adolescent mental health problems, and adolescent depression in particular, came the application of a range of treatments for adolescent problems and disorders. This in tum gave rise to a need, from funders and practitioners alike, to demonstrate the efficacy of the interventions. While traditional social science methods were utilised for this purpose, the rise of the field of evaluation brought new vigour to the area of efficacy of psychological treatments. It was this new approach that informed the structure and methodology for the present thesis. The aim of this thesis was to evaluate the William Slater Centre for Adolescents and Young Adults' psychotherapeutic milieu treatment programme. The efficacy of this milieu treatment programme was determined by analysing the following: (i) the structure of the programme; (ii) the process of the programme; and (iii) the short-term outcome of the programme. A combination of qualitative and quantitative methods were used. Results of the evaluation are manifold, with each chapter of the thesis providing insight into varying aspects of the Centre's therapeutic programme. Detailed descriptions of the structure and process of the William Slater Centre and its therapeutic programme is provided. This is followed by an in-depth account of the implementation of the therapeutic programme, where details of the day-to-day functioning of the programme is provided. The final part of the thesis is a brief examination of the short-term outcome of the programme and the staff and adolescent patients' perceptions of the strengths and limitations of the Centre's programme. The thesis provides a comprehensive overview of the structure and functioning of the William Slater Centre and its programme. Emphasis is placed on the concordance of the therapeutic programme with milieu therapy principles. The thesis demonstrates that while the Centre provides an essential service to the adolescent psychiatric population, significant organisational problems of the Centre and the programme require attention.
Kim, Ui-jung. "The effects of milieu teaching procedures on the spoken language skills of children with autism /." Digital version:, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p9992835.
Full textGay, Chloe. "Développement de stratégies éducatives auprès de patients souffrant de gonarthrose, en milieu thermal." Thesis, Université Clermont Auvergne (2017-2020), 2017. http://www.theses.fr/2017CLFAS011/document.
Full textThe aim of this work was to develop educational strategies in association with spa therapy treatment for patients with knee osteoarthritis, with a goal not only of clinical, psychological but also of improvement of the level of physical activity. A total of 745 patients with knee osteoarthritis were recruited from the 9 member’s thermal spa of the Innovatherm Cluster and distributed among the 3 studies building this project. The first study looked at the qualitative analysis of facilitators and barriers to physical activity. The second study on the level of physical activity and the analysis of the factors influencing the practice. The third study evaluated the effects of a self-management exercise education program in spa therapy resort. Analysis of the results of studies 1 and 2 showed the level of physical activity was significantly dependent on certain anthropometric data (gender, BMI, obesity), extrinsic factors (life situation, family situation) and intrinsic factors (motivation, well-being, self-efficacy, fatigue, aging, fear of aggravating knee osteoarthritis). Study 3 showed that spa treatment associated with or without self-management exercise program significantly increases the physical activity level, with medium effect size 0.53 [0.28; 0.77] at 3 months. Exercise education has a significant beneficial effect between groups in favor of the intervention group on anxiety, depression and fears and beliefs. These studies confirm the impact of spa therapy treatment on the clinical parameters of osteoarthritis and provide new data on the increase of the physical activity level and argue in favor of the cognitive and psychological effect of the self-management exercise program
Fortune, Tracy. "Establishing an occupational milieu in aged mental health units : an occupational ethnography." Phd thesis, Faculty of Health Sciences, 2003. http://hdl.handle.net/2123/5458.
Full textKoskinen, Erik. "Unga vuxnas upplevelse av institutionell miljöterapi." Thesis, Stockholm University, Department of Social Work, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-26396.
Full textTHE AIM OF THIS STUDY WAS TO INVESTIGATE YOUNG ADULTS EXPERIENCE´ OF RESIDENTIAL TREATMENT. THE STUDY WAS QUALITATIVE, BASED ON INTERVIEWS WITH FIVE RESPONDENTS WHO HAD STAYED AT A TREATMENT HOME FOR A LONG PERIOD OF TIME. THE FOCUS WAS ON THE RESPONDENTS´ EXPERIENCES OF MILIEU THERAPY AND THEIR VIEW ON NORMALITY. THE RESULTS WERE ANALYZED FROM EARLIER RESEARCH, THEORIES FROM SYMBOLIC-INTERACTIONISM AND ANTONOVSKYS´ THEORY ABOUT SENSE OF COHERENCE. THE RESULTS SHOWED THAT THE RESPONDENTS HAD TO EXAGGERATE THEIR DYSFUNCTIONAL BEHAVIOUR IN ORDER TO FIT AMONG THE OTHER RESIDENTS. THE GROUP OF RESIDENTS HAD A MAJOR IMPACT ON THE RESPONDENTS´ EXPERIENCE OF THE STAY. THEY ALSO EXPERIENCED THAT SOCIO-PSYCHOLOGICAL PROBLEMS WERE CONTAGIOUS WITHIN THE GROUP. AFTER THE TREATMENT THE RESPONDENTS FELT MORE SECURE IN THEMSELVES AND HAD A BETTER CONNECTION WITH THEIR FAMILIES. NORMALIZATION THROUGH EDUCATION SEEMS TO HAVE TAKEN PLACE SINCE ALL THE RESPONDENTS EXCEPT ONE ARE INVOLVED IN AN EDUCATION-PROGRAM NOW.
Junger, Anette. "Barns upplevelse av intensiv familjeterapi (IFT)." Thesis, Ersta Sköndal Bräcke högskola, S:t Lukas utbildningsinstitut, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-6043.
Full textAlper, Rebecca Mae. "Developing a novel coding system for analyzing language stimulation behaviors during adult-child interactions." Thesis, University of Iowa, 2012. https://ir.uiowa.edu/etd/2809.
Full textJansson, Lena, and Caroline Karlsson. "Miljöterapeutisk institutionsbehandling : En studie om vägledande behandlingsprinciper och behandlingintegritet inom ungdomsvård." Thesis, Örebro University, Department of Behavioural, Social and Legal Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-2297.
Full textSammanfattning
Ungdomar med antisocial problematik är en svårbehandlad grupp där ingen specifik metod har visat sig råda bot på hela problematiken kring ungdomen. Bäst utgång att behandla ungdomar med beteendeproblem återfinns inom institutioner som har en enighet i personalgruppen kring de teorier som är gällande inom verksamheten, så kallad behandlingsintegritet. Syftet med studien var att granska om personalgruppen på en behandlingsverksamhet för ungdomar har ett gemensamt förhållningssätt utifrån de miljöterapeutiska behandlingsprinciper som vägleder verksamheten. Syftet konkretiserades utifrån följande frågeställningar: 1. Vilka behandlingsprinciper är vägledande inom verksamheten? 2. På vilket sätt kommer dessa principer till uttryck i det praktiska arbetet med ungdomarna? 3. I vilka avseenden är personalen samstämmiga respektive skiljaktiga i sitt utförande av behandlingsprinciperna? 4. Vilka framträdande hinder och möjligheter framkommer när det gäller att arbeta enhetligt och i linje med de terapeutiska målen? 5. Framkommer faktorer som genom att förändra centrala organisationsstrukturer skulle utveckla verksamheten? Uppsatsen har en kvalitativ metodansats. Observationer gjordes på verksamheten vid fem tillfällen och tre intervjuer genomfördes, två med personal i behandlingsgruppen och en med enhetens föreståndare. Det framgår att verksamheten till stor del arbetar enhetligt efter de essentiella behandlingsprinciper som är vägledande för miljöterapi, men att det finns aspekter som skulle kunna förbättras. Det framkommer även såväl möjliggörande som hindrande faktorer för upprätthållande av behandlingsintegritet. I diskussionen förs resonemang kring centrala begrepp såsom ledningens betydelse för en välfungerande organisation, behandlingsintegritet, personalens kompetens och tillgänglighet samt ungdomarnas möjlighet att påverka verksamhetens innehåll.
Abstract
Young people with antisocial problems are a difficult group to treat where no specific method has proven effectively for solving all the problems surrounding the youth. The best chance to treat youths with behavioral problems is found in institutions where staff members agree on the theories used, so called treatment integrity. The purpose of the Study was to find out whether staff members on a treatment institution for youths have a unanimous way of practicing the milieu therapeutic treatment principles guiding the institution, within the following questions: 1. Which essential principles of treatment guides the institution? 2. In what way do the personell practice these principles in treating the youths? 3. In what area/areas appears unanimous or differences in the way staff members practice the principles? 4. Which prominent problems and possibilities appear in working homogeneous and according to the therapeutic goals? 5. Do factors appear which by chancing prominent structures of the organisation would develop the institution? The Study includes a qualitative approach. Data were collected from five observations at the institution and three semistructured interviews with staff members and the manager. The result shows that the staff members overall are unanimous concerning the practice of the treatment principles, but also indicate that some aspects could be improved. Enabling as well as preventing factors for maintaining treatment integrity emerges. Central aspects of the discussion are the management’s importance for a functioning organization, treatment integrity, competence and availability among staff members and the youth’s ability to influence the content of treatment.
Luiker, Henry George. "Predictors of outcome for severely emotionally disturbed children in treatment." University of Sydney, 2008. http://hdl.handle.net/2123/2571.
Full textDespite general agreement that severely emotionally disturbed children and adolescents are an "at risk" group, and that ongoing evaluation and research into the effectiveness of services provided for them is important, very little outcome evaluation actually takes place. The absence of well-conducted and appropriately interpreted studies is particularly notable for day or residential treatment programs, which cater for the most severely emotionally disturbed youths. This thesis outlines the main areas of conceptual, pragmatic and methodological confusion and neglect which impede progress in research in this area. It argues for plurality of data analytic strategies and research designs. It then critically reviews the reported findings about the effectiveness of day and residential treatment in specialist facilities, and the predictors of good outcomes for this treatment type. This review confirms that there is very little to guide practice. Having argued for the legitimacy of its methods and the necessity to address basic questions, the thesis reports the results of a naturalistic study based on data accumulated during a decade-long evaluative research program taking place at Arndell Child and Adolescent Unit, Sydney. The study addresses the question of what child, family and treatment variables predict outcome for 159 children and adolescents treated at this facility from 1990 to 1999. Statistically significant results with large effect size were obtained. Among the most disturbed subgroup of forty three children, (a) psychodynamic milieu-based treatment was shown to be more effective than the “empirically-validated” cognitive-behavioural treatment which superseded it in 1996, and (b) children from step-families showed better outcome than those from other family structures. Furthermore, it was found for the study sample as a whole that severe school-based problem behaviours were associated with a limited trajectory of improvement in home-based problem behaviour. These results are discussed with regard to implications for treatment, research methodology, policy and further studies.
Luiker, Henry George. "Predictors of outcome for severely emotionally disturbed children in treatment." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/2571.
Full textBjörklund, Nathalie, and Hanna-Olivia Knuuttila. "Miljöterapi : En utvärdering enligt Critical incident-metoden." Thesis, Örebro universitet, Akademin för juridik, psykologi och socialt arbete, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-14643.
Full textThe purpose of this study is to evaluate an institution which carries out milieu and individual therapy regarding youth. Furthermore, the purpose of this study is to evaluate the way of working in critical situations according to critical incident-method. Therefore, the author found the following questions relevant to this evaluation: Which sort of critical situations arise according to employee’s experiences? How can we solve these critical situations within the operation? Are the solutions of these critical situations anchored to the milieu therapeutic theory? The evaluation is based upon information from 9 respondents, of which one of the respondents is the evaluator’s writer. The collected information represents observation, question formulas and supplementary interviews. The material consists of 50 critical situations in which 47 situations account for tables under the result of analysis plus connection to the milieu therapeutic theory and earlier research. In the material 6 core problems emerge: threats and violence, occupational roll, and work groups, alcohol and nar-cotics break towards the operational structure, youth towards work groups and shifts in indi-vidual youths. The result shows that all solutions are supportive of the milieu therapeutic theory.
Khellaf, Feriel. "List-mode proton CT reconstruction." Thesis, Lyon, 2020. http://www.theses.fr/2020LYSEI074.
Full textProton therapy is used for cancer treatment to achieve better dose conformity by exploiting the energy-loss properties of protons. Proton treatment planning systems require knowledge of the stopping-power map of the patient’s anatomy to compute the absorbed dose. In clinical practice, this map is generated through a conversion from X-ray computed tomography (CT) Hounsfield units to proton stopping power relative to water (RSP). This calibration generates uncertainties as photon and proton physics are different, which leads to the use of safety margins and the reduction of dose conformity. In order to reduce uncertainties, proton CT (pCT) was proposed as a planning imaging modality since the reconstructed quantity is directly the RSP. In addition to energy loss, protons also undergo multiple Coulomb scattering (MCS) inducing non-linear paths, thus making the pCT reconstruction problem different from that of X-ray CT. The objective of this thesis is to improve image quality of pCT list-mode reconstruction. The use of a most likely path (MLP) formalism for protons to account for the effects of MCS has improved the spatial resolution in pCT. This formalism assumes a homogeneous medium. The first contribution of this thesis is a study on proton paths in heteregeneous media: the accuracy of the MLP was evaluated against a Monte Carlo generated path in different heterogeneous configurations. Results in terms of spatial, angular, and energy distributions were analyzed to assess the impact on reconstruction. The second contribution is a 2D directional ramp filter used for pCT data reconstruction. An intermediate between a filtered backprojection and a backproject-filter approach was proposed, based on the extension of the usual ramp filter to two dimensions, in order to preserve the MLP spatial information. An expression for a band-limited 2D version of the ramp filter was derived and tested on simulated pCT list-mode data. Then, a comparison of direct reconstruction algorithms in terms of spatial resolution and RSP accuracy was conducted. Five algorithms, including the 2D directional ramp, were tested to reconstruct different simulated phantoms. Results were compared between reconstruction from data acquired using idealized or realistic trackers. Finally, the last contribution is a deconvolution method using the information on the MLP uncertainty in order to improve spatial resolution of pCT images
LE, BOUILLE JEAN. "Etude comparative des productions graphiques d'un groupe de schizophrenes et d'un groupe temoin en atelier de peinture en milieu institutionnel." Toulouse 3, 1991. http://www.theses.fr/1991TOU31545.
Full textLudwig, Nicolas. "Modification d’acides aminés et de protéines en milieux aqueux sous faisceau d'ions." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAE020/document.
Full textThe goal of this thesis is to achieve a better understanding of fundamental mechanisms of the radiolysis of biomolecules by accelerated ions, at the molecular scale. To do so, different type of ions have been used (H+, He2+, C6+) at various energies, corresponding to densities of energy deposition from 0,3 to 1000 eV/nm.The main component in biological systems is water. Therefore, the comprehension of the water radiolysis under ions irradiation is essential. One of the most reactive species produced in aerated conditions, the hydroxyl radical (HO•), has been quantified using a specific probe, the 3- carboxylic acid coumarin.Indirect effects of radiolysis on biomolecules, involving water radiolysis species, have been studied in dilute aqueous solutions on two different systems: phenylalanine, an amino acid, and a protein, myoglobin. Direct radiolysis effect were studied on concentrated hydrogels of myoglobin ad other proteins. Elucidation of radiolysis mechanisms and quantification of phenylalanine radiolysis products were systematically performed
Diemand, Sarah Catherine. "Validity of the Miller Function and Participation Scales." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1245281688.
Full textSchnaufer, Hanspeter. "Der Einfluss serieller UV-Therapie auf arteriellen Blutdruck, Herzfrequenz und Kalziumstoffwechsel bei Patienten mit milder Hypertonie." [S.l.] : [s.n.], 2003. http://www.diss.fu-berlin.de/2003/203/index.html.
Full textLemoine, Anne-Isabelle. "Thérapie génique de la mucoviscidose : étude de l'influence de la nature du milieu sur la transfection à l'aide du lipide cationique BGTC de type guanidinium-cholestérol." Paris 5, 1997. http://www.theses.fr/1997PA05P155.
Full textRombach, Stefan [Verfasser]. "Renale Sympathikus-Denervation bei Patienten mit milder therapierefraktärer arterieller Hypertonie : Wirksamkeit der Therapie und Identifikation von Prädiktoren für ihr Ansprechen / Stefan Rombach." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1112552936/34.
Full textVoß, Sandra [Verfasser], Stefan [Akademischer Betreuer] Zielen, and Jan David Alexander [Akademischer Betreuer] Groneberg. "Wirksamkeit, Sicherheit und Verträglichkeit einer autologen E.coli-Autovaccine-Therapie bei Hausstaubmilben-Allergikern mit intermittierendem oder mildem persistierendem Asthma bronchiale / Sandra Voß. Gutachter: Stefan Zielen ; Jan David Alexander Groneberg." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2012. http://d-nb.info/1044412860/34.
Full textMasson, Christophe. "Transfert de gênes cible vers les tumeurs : conception, synthèse et propriétés de nouveaux vecteurs chimiques de l'ADN pour le ciblage des cellules cancéreuses." Paris 6, 2001. http://www.theses.fr/2001PA066166.
Full textTill, Ugo Valentin. "Oncopol - Vers le développement critique de vecteurs polymères pour l'oncologie." Thesis, Toulouse, INPT, 2016. http://www.theses.fr/2016INPT0065/document.
Full textThe objective of this study was to critically analyze different polymer self-assemblies used for photodynamic therapy (PDT) and to link this analysis to their therapeutic efficiency. To do that, a thorough characterization of the vectors has been performed by classical techniques such as Dynamic Light Scattering or electron Microscopy, but also using flow fractionation, which has been seldomly used so far for polymeric self-assemblies. In a second step, these have been used as vectors of a photosensitizer, namely Phéophorbide a, and the therapeutic efficiency assessed on both 2D and 3D cell cultures of HCT 116 (colon cancer) and FaDu (head and neck cancer) cells. Different simple polymer vectors have first been evaluated, namely micelles and polymersomes based on diblock amphiphilic copolymers such as poly(ethylene-oxide-b--caprolactone), poly(ethylene-oxide-b-lactide) or poly(ethylene-oxide-b-styrene). This enabled obtaining vectors exhibiting various sizes and morphologies. Results in PDT showed different behaviours and a better efficiency in 3D for PEO-PDLLA. The Asymmetric Flow Field Flow Fractionation was particularly used for these systems to demonstrate their purity. The acquired expertise on this part enabled us to also characterize vectors made of known mixtures of micelles and polymersomes. These revealed antagonism and synergy effects in PDT, demonstrating the presence of complex processes for the cell response. Other self-assemblies consisting of crosslinked systems have also been developed and characterized. These were observed to be particularly efficient for PDT on 3D cell cultures. The comparison of these results with those for the 2D cell culture enabled to highlight the difference between those two biological systems. Finally, self-assemblies based on Polyion Complexes were also formed and characterized. Field Flow Fractionation was once again used as a powerful technique for this, although this implied the use of a special injection device called Frit Inlet. Their PDT efficiency however proved to be low
Morales, Delphine. "Modèles 3D de mélanome métastatique pour l’évaluation in vitro de l’efficacité de molécules de thérapies ciblées." Thesis, Compiègne, 2019. http://www.theses.fr/2019COMP2498.
Full textMelanoma cell sensitivity to targeted therapy molecules is dependent on the tumor microenvironment (cell-cell and cell-extracellular matrix interactions). Three dimensional (3D) in vitro cell culture systems better reflect the native structural architecture of tissues and are attractive to investigate cellular interactions. We have developed and compared several metastatic melanoma models: melanoma cells (SK-MEL-28 and SK-MEL-3, BRAF V600E mutant and SK-MEL-2 BRAF wt) cultured as a monolayer (2D) and co-cultured on 3D dermal equivalents with fibroblasts to better unravel factors modulating cell sensitivity to a BRAF inhibitor (BRAFi, Vemurafenib) and a BRAFi combined with a MEK inhibitor (MEKi, Cobimetinib). Cell sensitivity to treatments was evaluated under various aspects: cell proliferation (cell counting, EdU incorporation, MTS assay), MAPK and PKB/Akt signaling pathway analysis (Western-blotting), apoptosis (TUNEL), cytokine and growth factor release (ELISA) and histology (3D models). A cytostatic effect of BRAFi was observed on SK-MEL-28 and SK-MEL-3 cells in both models. SK-MEL-2 cell line was clearly resistant to BRAFi when cultured as a monolayer but not when co-cultured with 3D fibroblasts embedded in a type I collagen matrix. Conditioned media provided by 3D fibroblasts (dermal equivalents) underlined 2D SK-MEL-2 sensitivity to BRAFi. Cell culture supernatant analysis revealed that dermal equivalents released some soluble factors (IL-6, IL-8, HGF, TGF-β): these secretions were modified during vemurafenib treatment. The combination of treatment with MEKi enhances the action of Vemurafenib on metastatic melanoma cells while decreasing the proliferation capacity of fibroblasts. Cell populations containing melanoma cells or fibroblasts associated with cancer (CAFs) were isolated from a cutaneous metastasis biopsy of a patient with metastatic melanoma. These cells allowed the realization of patient-specific models of metastatic melanoma in order to study in vitro the sensitivity of the patient’s melanoma cells to treatments in a tumor microenvironment (paracrine secretion of stromal cells and collagen matrix). These 3D predictive patient-specific models could be used to determine personalized therapy strategies, as well as to understand the resistance phenomena of melanoma cells to treatments
"Enhanced Milieu Training with Phonological Emphasis (EMT+PE) A Pilot Telepractice Parent Training Study." Master's thesis, 2020. http://hdl.handle.net/2286/R.I.57416.
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Masters Thesis Communication Disorders 2020
Lapierre, Nolwenn. "Implantation d’un système de vidéosurveillance intelligente pour détecter les chutes en milieu de vie." Thèse, 2018. http://hdl.handle.net/1866/21842.
Full textProvencher, Véronique. "Influence du milieu d'évaluation sur la réalisation de tâches liées à la préparation de repas auprès de personnes âgées fragiles." Thèse, 2012. http://hdl.handle.net/1866/8498.
Full textThis thesis aims to advance the state of knowledge about the impact of assessment settings (home versus clinic) on meal preparation task performance in frail older adults. The thesis has three specific objectives and the results are presented in five articles. The first specific objective aims to review current knowledge about the concept of frailty in occupational therapy and the impact of assessment settings in frail older adults. First, a critical review about frailty was conducted. The results (article 1) demonstrate that a better understanding of the concept of frailty may help occupational therapists provide health care and services better tailored to the specific needs of this population. Second, a review of studies comparing performance of instrumental activities of daily living (IADL) between assessment settings was performed. The results (article 2) reveal that older adults without significant cognitive impairments tend to perform better in IADL tasks when assessed at home. Some factors, such as familiarity with the environment, may explain this difference. Based on this review, similar results might be expected with frail elders. The second specific objective aims to compare meal preparation task performance in home and clinical settings in a population of frail older adults. Thirty-seven frail older adults were thus assessed in home and clinical settings with the Assessment of Motor and Process Skills (AMPS) and the Performance Assessment of Self-Care Skills (PASS), using a counterbalanced design. The results (articles 3, 4, 5) globally demonstrate significantly better performance of participants when assessed at home. The third specific objective aims to identify demographic, physical, cognitive, psychological and environmental factors that may explain differences between assessment settings. The results (articles 3, 4, 5) indicate that a better performance in the home setting was mostly related to a decline in certain executive functions. Other cognitive, demographic, psychological, physical and environmental factors also contribute to explain the differences between assessment settings but to a lesser extent. Our findings may help occupational therapists identify frail older adults likely to present a different performance in the clinical setting and thus for whom home assessments would be advisable. Our findings could ultimately mean that frail clients are provided with services adapted to their needs, while ensuring an efficient allocation of health care resources.
Mondor, Josianne. "La thérapie conjugale en milieu naturel: Étude du lien entre attachement amoureux, satisfaction conjugale, mandat thérapeutique et résultat de la consultation." Thèse, 2009. http://hdl.handle.net/1866/3666.
Full textThe aim of this thesis was to elucidate the link between adult romantic attachment, relationship satisfaction, therapeutic mandates and couple therapy outcome. Couples seeking therapy in a natural setting completed the Dyadic Adjustment Scale (Spanier, 1976) and the Experiences in Close Relationships Questionnaire (Brennan, Clark, & Shaver, 1998) at intake. Therapists classified the therapeutic mandate pursued in each case (i.e., alleviation of couple distress or ambivalence resolution) according to the Classification of Therapeutic Mandates Questionnaire (Poitras-Wright & St-Père, 2004). When treatment ceased, couples were classified as dropouts or completers according to therapists’ judgment, and completers were further assessed using the Dyadic Adjustment Scale. In the first of two articles, the association between adult romantic attachment and pre-treatment marital satisfaction was investigated in a sample of 172 distressed couples seeking therapy, as well as in a comparison sample of 56 nondistressed couples seeking therapy. Results showed that attachment avoidance was a distinctive characteristic of distressed couples and that it was a strong predictor of marital dissatisfaction among distressed couples seeking therapy. Based on a series of 141 couple therapy cases, the second article examined therapeutic mandates, romantic attachment orientations, and pre-treatment marital satisfaction as predictors of premature disengagement from couple therapy. The most striking result was that an ambivalence resolution mandate was strongly associated with increased chances of treatment discontinuation. Predictors of couple therapy outcome were also examined: actor-partner analyses revealed that the strongest predictor of post-treatment marital satisfaction was pre-treatment marital satisfaction, despite the inclusion of romantic attachment among the predictor variables. Overall, these results indicate that attachment insecurity is strongly related to distressed couples’ marital dissatisfaction, but that it might not impede the attainment of a positive outcome in couple therapy. In sum, this thesis contributed to the field of couple therapy by investigating the pertinence of attachment theory in couple treatment, and highlighting the need for further study of therapeutic mandates in couple therapy. Clinical implications for couple therapy are discussed, and recommendations for clinical research offered.
Boisvert, Marie-Michèle. "Étude cliniquement représentative des problèmes conjugaux, des mandats et des objectifs thérapeutiques des couples consultant en thérapie conjugale." Thèse, 2011. http://hdl.handle.net/1866/5390.
Full textThe aim of this dissertation was to study the relationship problems, treatment goals and therapeutic mandates of couples consulting in couple therapy in a naturalistic setting. This dissertation includes two original articles. Using a relationship problems coding system on a sample of 108 couples seeking therapy, the first study identified that the most common relationship problems were related to communication, emotional affection or distance, specific areas of the current relationship, and lack of physical affection or sex. Comparisons of therapeutic mandates revealed that commitment or security problems and infidelity or flirting problems were more common among couples pursuing an ambivalence resolution mandate than among couples pursuing an alleviation of distress mandate. These results demonstrated the importance of identifying distinct therapeutic mandates in couple therapy and the need for further research about ambivalent couples. The second study aimed to evaluate change in couples that consulted in a naturalistic therapy setting using Goal Attainment Scaling (GAS). A categorization of treatment goals in couple therapy was proposed. Treatment goals and therapeutic mandates of 100 couples were categorized using standardized coding schemas. The results showed large pre-post changes in couples distress and severity of relationship problems. Therapists’ expectations about the therapy process, treatment completion and separation were related to couples’ goal attainment. Comparisons of therapeutic mandates revealed that couples pursuing an alleviation of distress mandate had more goals related to communication, problem-solving and acceptance of differences than couples pursuing an ambivalence resolution mandate. This study contributed to the field by providing preliminary data regarding the clinical utility of GAS in assessing change following couple therapy. Types of treatment goals set in naturalistic settings were presented and the results emphasized the need for further research on therapeutic mandates. In summary, this dissertation provided support to the construct of therapeutic mandates and presented clinical, methodological and theoretical implications.
Ruiz, Rodrigo Alicia. "Développement d’un instrument d’évaluation de l’environnement des personnes ayant un trouble du spectre de l’autisme." Thesis, 2020. http://hdl.handle.net/1866/25203.
Full textIntroduction: Autism Spectrum Disorder (ASD) is prevalent in 1% of the world's population. Within individuals living with ASD, some environmental elements (e.g., noise, light, distribution) are just some disruptive factors; the manifestations may persist throughout life. Therefore, it is important to assess the environment in order to provide interventions for adults living with ASD, improving their quality of life. Purpose: To develop tool for assessing the environment of adults living with ASD. Methods: This study was developed in two steps: 1) Exploration of environmental factors that impact young people living with ASD with parents and 2) Consultation of potential users about the first version of the HoPE - ASD version. Results: The HoPE-ASD version was developed on the basis of the Model of Competence, explaining the person-environment relationship, considering the human and non-human environmental components that have an impact on adults living with ASD (e.g., sensory elements, related to the safety and functionality of spaces, stability, visitors or trusted persons). During the consultation of potential users (occupational therapists), some modifications related to the content, mode of administration, format and applicability of the instrument were suggested. Conclusion: The HoPE-ASD version could fill a gap in the clinical and scientific practice of occupational therapists working with adults living with ASD. Thus, environmental interventions adapted to this population will be promoted.
Schnaufer, Hanspeter [Verfasser]. "Der Einfluss serieller UV-Therapie auf arteriellen Blutdruck, Herzfrequenz und Kalziumstoffwechsel bei Patienten mit milder Hypertonie / vorgelegt von: Hanspeter Schnaufer." 2003. http://d-nb.info/968618170/34.
Full textEls, Beate. "Verhalten der diastolischen linksventrikulären Funktion unter antihypertensiver Therapie mittels kombinierter Beta- und Alpharezeptoren-Blockade bei ambulanten Patienten mit milder arterieller Hypertonie /." 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014169306&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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