Relevant bibliographies by topics / Milieu therapy

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Milieu therapy'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2024

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Journal articles on the topic "Milieu therapy"

1

Thomson, I. G. "Milieu Therapy." Psychiatric Bulletin 10, no. 2 (February 1, 1986): 35–36. http://dx.doi.org/10.1192/pb.10.2.35.

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Thomson, I. G. "Milieu Therapy." Bulletin of the Royal College of Psychiatrists 10, no. 2 (February 1986): 35–36. http://dx.doi.org/10.1192/s0140078900026699.

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Smith, Mark. "‘Milieu-Therapy’ with Children." Social Work Education 29, no. 5 (August 2010): 576–77. http://dx.doi.org/10.1080/02615470903378592.

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Delaney, Kathleen R. "Milieu Therapy: A Therapeutic Loophole." Perspectives in Psychiatric Care 33, no. 2 (January 16, 2009): 19–28. http://dx.doi.org/10.1111/j.1744-6163.1997.tb00537.x.

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Millard, Hun, Susan Parke, Cynthia Wilson, Zheala Qayyum, Hyun Jung Kim, and Timothy Van Deusen. "Inpatient Milieu Therapy: Considerations for Adolescent and Transitional Age Youth." Adolescent Psychiatry 10, no. 1 (April 24, 2020): 7–16. http://dx.doi.org/10.2174/2210676609666190617150025.

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Background and Goals: The role of milieu therapy on inpatient treatment has become more prominent due to the changing landscape of hospital care, with shorter length of stay, higher patient acuity, and rapid turnover. The modern inpatient unit promotes less individual psychotherapy with the psychiatrist or therapist, and more milieu and group based treatment that emphasizes acute stabilization. Methods: The authors share some of the core domains that provide the basic framework for milieu treatment within an acute care setting when working with adolescents and transitional age youth (TAY), with the aim to share clinical considerations for milieu therapy and offer practical ideas for implementation in clinical practice. Discussion: The therapeutic milieu and collaboration of an interdisciplinary team has a significant impact on hospital treatment. Considerations for milieu therapy implementation in an inpatient unit include developmentally informed concepts related to milieu treatment of adolescents and TAY patients in a hospital setting.
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Graham, Diane Robinson, Debra Kennedy, Christine Phibbs, and Debra Stewart. "L'ergothérapie en milieu scolaire." Canadian Journal of Occupational Therapy 57, no. 4 (October 1990): 7–10. http://dx.doi.org/10.1177/000841749005700402.

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Van Bilsen, H. P. J. G., and A. J. Van Ernst. "Heroin Addiction and Motivational Milieu Therapy." International Journal of the Addictions 21, no. 6 (January 1986): 707–13. http://dx.doi.org/10.3109/10826088609027388.

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MCGLASHAN, THOMAS H. "Principles and Practice of Milieu Therapy." American Journal of Psychiatry 142, no. 3 (March 1985): 379–80. http://dx.doi.org/10.1176/ajp.142.3.379.

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Burton, John. "Milieu-therapy With Children: Planned Environmental Therapy in Scandinavia." Children & Society 24, no. 2 (March 2010): 171–72. http://dx.doi.org/10.1111/j.1099-0860.2009.00275.x.

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Dahlin, Olov. "Erfarenheter I Miljoterapi (Experiences in Milieu Therapy)." International Journal of Group Psychotherapy 38, no. 2 (April 1988): 267–68. http://dx.doi.org/10.1080/00207284.1988.11491109.

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Dissertations / Theses on the topic "Milieu therapy"

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Kruger, Maria Elizabeth. "The play milieu at creches in Macassar." Thesis, Stellenbosch : Stellenbosch University, 2011. http://hdl.handle.net/10019.1/18025.

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Thesis (MOccTher)--Stellenbosch University, 2011.
ENGLISH ABSTRACT: Play is widely acknowledged as a cornerstone of childhood development. Its significance stretches beyond developing cognitive abilities and school readiness to the development of social skills, emotional expression and well-being. The milieu, or environment, is recognized as highly influential with regards to occupational performance; the play environment is therefore also of great importance to child development. However, there is a lack of knowledge regarding the assessment of this play environment, especially in a developing country context. This study therefore focuses on the play environment at South African crèches, specifically with regards to assessing the environmental factors impacting children’s play, namely play space, play objects, play time and play mates (including caregivers). The National Guidelines of ECD Services in South Africa had already set standards relating to play space, play time and caregiver ratio’s at crèches. Criteria for play objects were established as part of this study through an extensive literature review. These criteria were then applied in a quantitative, cross-sectional descriptive survey at registered crèches in Macassar, a community in the Cape Flats outside Cape Town. The survey results indicated that crèches complied to play space and play time regulations, but that not all crèches complied with the regulations regarding caregiver-child ratio’s and play object adequacy. The crèches especially lacked in gross motor play objects. These findings emphasize the importance of establishing practical criteria and guidelines for all aspects of the play environment and enforcing those standards at day care crèches. The study also provides a useful framework for measuring the adequacy of the play environment at South African crèches.
AFRIKAANSE OPSOMMING: Spel is ‘n belangrike hoeksteen in kinderontwikkeling en het ‘n noemenswaardige impak op kognitiewe ontwikkeling, skoolgereedheid, die ontwikkeling van sosiale vaardighede, uitdrukking van emosies en algemene welstand. Die milieu, of omgewing, word wyd aangeslaan vir die invloed wat dit op arbeidsverrigting uitoefen en die spelomgewing is daarom belangrik. Daar is egter ‘n tekort in kennis aangaande die spel omgewing, veral in die konteks van ‘n ontwikkelende land soos Suid-Afrika. Hierdie studie bestudeer dus die spel omgewing in Suid-Afrikaanse dagsorgsentrums. Speel-spasie, speeltyd, speelgoed en speel-maats vorm saam die omgewingsfaktore wat op die spel omgewing impakteer en die studie fokus dus op hierdie vier faktore. Die Nasionale Riglyne vir Voorskoolse Kinder Ontwikkeling in Suid Afrika het reeds standaarde gestel ten opsigte van die vewagte fisiese spasie, speeltyd en die getal kinders tot versorgers (versorger-kind verhouding) by Suid Afrikaanse dagsorg sentrums. Kriteria wat meet of daar voldoende speelgoed beskikbaar is vir kinders se optimale ontwikkeling is na aanleiding van ‘n literatuurstudie ontwikkel. Hierdie kriteria, tesame met die kriteria wat deur die Nasionale Riglyne gestel is, is gebruik om die spelomgewing by dagsorg-sentrums in die Macassar gemeenskap op die Kaapse Vlaktes net buite Kaapstad te meet d.m.v ‘n beskrywende opname. Volgens die sensus resultate voldoen die dagsorgsentrums wel aan kriteria ten opsigte van fisiese spasie en beplande speeltyd, maar ontbreek hulle ten opsigte van die versorger-kind verhouding. Die resultate dui ook aan dat al die dagsorg-sentrums nie voldoende speelgoed gehad het om die volle spektrum van kinderontwikkeling te dek nie. Hulle het veral ontbreek in speelgoed vir grof-motoriese spel. Die studie beklemtoon die belang van praktiese en spesifieke riglyne en standaarde sowel as die implementering van hierdie standaarde. Die studie verskaf ook ‘n raamwerk wat gebruik kan word in die assesering van die spel omgewing in ‘n ontwikkelende konteks, sowel as om toekomstige intervensies te lei.
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Johnson, Catherine. "The effect of milieu therapy on personality and clinical symptom variables." Master's thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/13478.

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Bibliography: leaves 66-70.
The present exploratory study was conducted in Ward G22, a milieu therapy unit at Cape Town's Groote Schuur Hospital. It considers aspects of the unit's selection process, as well as particular treatment-related considerations, using a self-report questionnaire, the revised Millon Clinical Multiaxial Inventory (MCMI-II). The MCMI-II provided information about clinical symptoms and personality styles, which was used to investigate what change may be measured in patients after a 12-week stay in G22. On the strength of this information, the study sought to make suggestions as to what aspects of patient difficulties are most amenable or resistant to the unit's intervention. Lastly, it intended to make recommendations on the value of the routine use of the MCMI-II in assessing patients for admission, and in evaluating therapeutic change.
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Cannaday, Austin M. "Effectiveness of DBT in the Milieu regarding Increased Therapy Progress with At-Risk Adolescents." Thesis, Prescott College, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1605543.

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This research aims to provide evidence that will serve to better the quality of treatment in residential care settings for the at-risk adolescent population. Because of the various factors associated with iatrogenic effects in residential care settings and because of the impact that the developmental stage of adolescence has on later adulthood, attempts to increase this treatment quality type becomes salient. Contemporarily, dialectical behavioral therapy is utilized in residential care settings with the at-risk adolescent population and has research supporting its’ efficacy. Although dialectical behavioral therapy is utilized in this context and has demonstrated effective, it is often only provided in therapy and not in the milieu. Because of the quantity of time clients in residential care settings spend in the milieu with milieu staff, these experiences likely influence their overall therapy progress. Therefore, this research hypothesizes that dialectical behavioral therapy’s use in the milieu in addition to therapy will increase overall therapy progress for the client population than if treatment as usual were to proceed. This research was conducted in a residential care setting for at-risk adolescents and collected data during a treatment as usual assessment period; provided the intervention of training milieu staff in dialectical behavioral therapy theory, strategies, and adolescent adaptations; and collected data during a dialectical behavioral therapy treatment assessment period. Concluding is a statistical analysis of the measurable changes between assessment periods, an interpretation of the results, a discussion regarding generalization of the findings, limitations, and future considerations.

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Shirelele, T. I. "Mbangu eka tsalwa ra i vutomi hi C.M. Lubisi na ra xona hi xihi? hi D.R. Maluleke." Thesis, University of Limpopo, 2011. http://hdl.handle.net/10386/2379.

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Thesis (M.A.) --University of Limpopo, 2011
This study is to conduct a detailed study of milieu in a number of Xitsonga novels in I Vutomi by Lubis CM and Xona hi Xihi? by DR Maluleke. This study also emphasizes on how the characters are depicted in rural areas and urban places. Lubisi and Maluleke are able to enlighten the community about the importance of establishing the distinct relationship between space and time. The first chapter is a general introduction that outlines and provides background of the study. Milieu as well as its manifestation in I Vutomi and Xona hi Xihi? is discussed in the second chapter. The third chapter deals with characterization. In the fourth chapter, the main theme of the novels is critically examined. The fifth chapter is a brief overview of the first four chapters. It also summarizes the findings of the research and provides recommendations.
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Lipusch, James T. "An exploration of influences of staff responses to adolescents on a twenty-four hour treatment milieu with special emphasis on self psychology /." Click here for text online. The Institute of Clinical Social Work Dissertations website, 1989. http://www.icsw.edu/_dissertations/lipusch_1989.pdf.

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Dissertation (Ph.D.) -- The Institute for Clinical Social Work, 1989.
A dissertation submitted to the faculty of the Institute of Clinical Social Work in partial fulfillment for the degree of Doctor of Philosophy.
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Fortune, Tracy. "Establishing an occupational milieu in aged mental health units an occupational ethnography /." Connect to full text, 2002. http://hdl.handle.net/2123/5458.

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Thesis (Ph. D.)--University of Sydney, 2003.
Title from title screen (viewed Oct. 26, 2009) Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Discipline of Surgery, Faculty of Health Sciences. Degree awarded 2003; thesis submitted 2002. Includes bibliography. Also available in print form.
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Ahmed, Nazeema. "An evaluation of the psychotherapeutic milieu therapy programme of the William Slater Centre for Adolescents and Young Adults." Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/13458.

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Bibliography: leaves 194-227.
In recent years there has been increasing recognition of the turmoil of the adolescent developmental period. This has primarily been the result of research demonstrating high morbidity, and at times mortality, for this age group. With the acknowledgement of adolescent mental health problems, and adolescent depression in particular, came the application of a range of treatments for adolescent problems and disorders. This in tum gave rise to a need, from funders and practitioners alike, to demonstrate the efficacy of the interventions. While traditional social science methods were utilised for this purpose, the rise of the field of evaluation brought new vigour to the area of efficacy of psychological treatments. It was this new approach that informed the structure and methodology for the present thesis. The aim of this thesis was to evaluate the William Slater Centre for Adolescents and Young Adults' psychotherapeutic milieu treatment programme. The efficacy of this milieu treatment programme was determined by analysing the following: (i) the structure of the programme; (ii) the process of the programme; and (iii) the short-term outcome of the programme. A combination of qualitative and quantitative methods were used. Results of the evaluation are manifold, with each chapter of the thesis providing insight into varying aspects of the Centre's therapeutic programme. Detailed descriptions of the structure and process of the William Slater Centre and its therapeutic programme is provided. This is followed by an in-depth account of the implementation of the therapeutic programme, where details of the day-to-day functioning of the programme is provided. The final part of the thesis is a brief examination of the short-term outcome of the programme and the staff and adolescent patients' perceptions of the strengths and limitations of the Centre's programme. The thesis provides a comprehensive overview of the structure and functioning of the William Slater Centre and its programme. Emphasis is placed on the concordance of the therapeutic programme with milieu therapy principles. The thesis demonstrates that while the Centre provides an essential service to the adolescent psychiatric population, significant organisational problems of the Centre and the programme require attention.
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Kim, Ui-jung. "The effects of milieu teaching procedures on the spoken language skills of children with autism /." Digital version:, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p9992835.

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Gay, Chloe. "Développement de stratégies éducatives auprès de patients souffrant de gonarthrose, en milieu thermal." Thesis, Université Clermont Auvergne‎ (2017-2020), 2017. http://www.theses.fr/2017CLFAS011/document.

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L’objectif de ce travail était de développer des stratégies éducatives en association avec une cure thermale à destination de patients porteurs de gonarthrose, avec un objectif non seulement d’efficacité clinique et psychologique mais aussi d’amélioration du niveau d’activité physique. Au total, 745 patients souffrants de gonarthrose ont été recrutés sur les 9 stations thermales membre du Cluster Innovatherm et répartis dans les 3 études composant ce projet. La première étude porte sur l’analyse qualitative des freins et des leviers à la pratique d’activité physique. La seconde étude a mesuré le niveau d’activité physique et analysé les facteurs influençant la régularité de la pratique. La troisième étude a évalué les effets d’un programme d’éducation à l’exercice en milieu thermal. L’analyse des résultats des 2 premières études a montré que le niveau d’activité physique des gonarthrosiques était significativement dépendant de certaines données sociodémographiques, anthropométriques (genre, indice de masse corporelle, obésité), de facteurs extrinsèques (lieu de vie, situation familiale) et de facteurs intrinsèques (motivation, bien être, « self-efficacy », fatigue, vieillissement, peur d’aggraver la gonarthrose). La troisième étude a montré que le traitement thermal associé ou non aux ateliers d’éducation à l’exercice permettait d’augmenter significativement le niveau d’activité physique, avec un effet taille moyen de 0.53 [0.28;0.77] à 3 mois. Les ateliers d’éducation à l’exercice ont un effet bénéfique significatif sur l’anxiété, la dépression et les peurs et croyances (sous item médecin du KOFBeQ), à 3 mois. Ces études confirment l’impact du traitement thermal sur les paramètres cliniques de la gonarthrose et fournissent de nouvelles données concernant ce traitement sur l’évolution du niveau d’activité physique. Cette étude argumente en faveur de l’effet cognitif et psychologique du programme d’éducation à l’exercice
The aim of this work was to develop educational strategies in association with spa therapy treatment for patients with knee osteoarthritis, with a goal not only of clinical, psychological but also of improvement of the level of physical activity. A total of 745 patients with knee osteoarthritis were recruited from the 9 member’s thermal spa of the Innovatherm Cluster and distributed among the 3 studies building this project. The first study looked at the qualitative analysis of facilitators and barriers to physical activity. The second study on the level of physical activity and the analysis of the factors influencing the practice. The third study evaluated the effects of a self-management exercise education program in spa therapy resort. Analysis of the results of studies 1 and 2 showed the level of physical activity was significantly dependent on certain anthropometric data (gender, BMI, obesity), extrinsic factors (life situation, family situation) and intrinsic factors (motivation, well-being, self-efficacy, fatigue, aging, fear of aggravating knee osteoarthritis). Study 3 showed that spa treatment associated with or without self-management exercise program significantly increases the physical activity level, with medium effect size 0.53 [0.28; 0.77] at 3 months. Exercise education has a significant beneficial effect between groups in favor of the intervention group on anxiety, depression and fears and beliefs. These studies confirm the impact of spa therapy treatment on the clinical parameters of osteoarthritis and provide new data on the increase of the physical activity level and argue in favor of the cognitive and psychological effect of the self-management exercise program
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Fortune, Tracy. "Establishing an occupational milieu in aged mental health units : an occupational ethnography." Phd thesis, Faculty of Health Sciences, 2003. http://hdl.handle.net/2123/5458.

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Books on the topic "Milieu therapy"

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Kornerup, Hans. "Milieu-therapy" with children: Planned environmental therapy in Scandinavia. Lejre: Perikon, 2009.

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M, Goldsmith Jerome, and Sanders Jacquelyn Seevak, eds. Milieu therapy: Significant issues and innovative applications. New York: Haworth Press, 1993.

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H, Wright Jesse, ed. Cognitive therapy with inpatients: Developing a cognitive milieu. New York: Guilford Press, 1993.

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Mornet, Joseph. Psychothérapie institutionnelle: Histoire & actualité. Nîmes: Champ social, 2007.

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Ahlin, Göran. Erfarenheter i miljöterapi. [Stockholm]: Natur och kultur, 1986.

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Oury, Jean. Psychothérapie institutionnelle: Rencontre avec le Japon : Jean Oury à Okinawa, Kyoto, Tokyo. Vigneux: Matrice, 2007.

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Allione, Claude. La part du rêve dans les institutions: Régulation, supervision, analyse des pratiques. La Versanne: Encre marine, 2005.

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Henri-Ménassé, Catherine. Analyse de la pratique en institution: Scène, jeux, enjeux. Toulouse: Érès, 2009.

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Henri-Ménassé, Catherine. Analyse de la pratique en institution: Scène, jeux, enjeux. Toulouse: Érès, 2009.

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Lee, Lesley. Occupational therapy: An eclectic profession : our place in today's scientific milieu. [S.l.]: [s.n.], 1990.

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Book chapters on the topic "Milieu therapy"

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Abroms, Eugene M. "Guided Intimacy and Milieu Therapy." In The Freedom of the Self, 205–26. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2896-8_11.

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Gussak, David E. "Art Therapy in the Prison Milieu." In The Wiley Handbook of Art Therapy, 478–86. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118306543.ch46.

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Sarmiento, Karen, and Isabelle Feijo. "Family Therapy." In Longer-Term Psychiatric Inpatient Care for Adolescents, 69–75. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-1950-3_8.

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AbstractThe hospitalisation of a young person, particularly over an extended period of time, inevitably impacts on the entire family. Prior to admission to the Walker Unit, the young person and their family will have typically engaged with several other inpatient services and will have been exposed to a range of psychological and pharmacological treatments, with mixed results. However when discharged into the same unchanged family milieu, a deterioration can occur resulting in rehospitalisation and the need for further intensive care. By the time families arrive at a Walker admission, they are probably suffering treatment fatigue due to the impact of long hospitalisation and the impact of chronic mental illness. This needs to be overcome.
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Neuhauser, D. "The Changing Economic Milieu in the United States." In Socioeconomic Evaluation of Drug Therapy, 7–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-61366-1_2.

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Hankin, R. "The Economic Milieu in Europe: View of the Common Market." In Socioeconomic Evaluation of Drug Therapy, 15–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-61366-1_3.

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Taylor, D. "The Economic Milieu in Europe: View of the Pharmaceutical Industry." In Socioeconomic Evaluation of Drug Therapy, 23–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-61366-1_4.

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Bernstein, David P., Marjolein F. van Wijk-Herbrink, and Truus Kersten. "Forensic Schema Therapy and SafePath: Individual- and Milieu-Therapy Approaches for Complex Personality Disorders and Externalizing Behavior Problems." In Clinical Forensic Psychology, 587–608. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-80882-2_30.

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Griepenstroh, D. "Ego-Structural Milieu Therapy in the Conception of Ammon’s Theory of Dynamic Psychiatry." In Medicolegal Library, 264–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-82574-3_35.

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Mordasini, R., and W. F. Riesen. "Krankheitsrisiko und Nutzen der Therapie bei Fettstoffwechselstörungen." In Milde Hypertonie und leichte Fettstoffwechselstörungen, 23–34. Heidelberg: Steinkopff, 1986. http://dx.doi.org/10.1007/978-3-642-72392-6_3.

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Anlauf, M., and F. Weber. "Krankheitsrisiko und Nutzen der Therapie bei milder Hypertonie." In Milde Hypertonie und leichte Fettstoffwechselstörungen, 7–22. Heidelberg: Steinkopff, 1986. http://dx.doi.org/10.1007/978-3-642-72392-6_2.

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Conference papers on the topic "Milieu therapy"

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Premasiri, A., G. Happawana, and A. Rosen. "Portable Photonics Optical Detection System for Monitoring Molecular Oxygen and Photosensitizer Concentration in Photodynamic Therapy Milieu." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-66202.

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Photodynamic therapy (PDT) is an FDA approved, effective, and minimally invasive cancer treatment modality with few side effects. Optimization of the PDT protocol for individual patient requires good therapeutic selectivity and high efficacy. This is possible only by enabling continuous monitoring of treating area of each patient for essential components for PDT. Two most essential components of PDT are photosensitizing agents and molecular oxygen. Currently the PDT is rather a blind process since there are no proper methods to monitor the tumor blood oxygen level and photosensitizer concentration during the treatment. In this paper we present an optical technique to monitor the tumor oxygen level and photosensitizer concentration. The technique investigated in this paper is a reflection optical technique designed with tiny semiconductor lasers and a silicon photodiode. The measurement of blood oxygen level with optical technique is not an uncommon method, but conventional transmission technique cannot be applied to the internal organs such as esophagus, trachea, and intestine. The light used in the monitoring system comes from three semiconductor diode lasers of 630nm, 650 nm and 940 nm wavelengths. Three lasers and the photodiode are mounted on to a small package to be able to imprint on to the balloon catheter that the PDT light delivery system is carrying in case of body cavities. Lasers and the photodiode are powered and controlled by the control box that is connected with a tinny cable. Light sources and respective photodiode output is controlled by the LabVIEW virtual instrumentation. The sequential on and off of light source and respective reflective signal is processed with MATLAB code integrates in the LabVIEW to make automatic calculation of the corresponding light absorption by each chromophore and to show the change in oxygen level and the photosensitizer concentration in the monitoring area. The designed system is capable of monitoring change in oxygen and photosensitizer level in any part of the human body where the tinny package is possible to place.
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Wang, Juncheng, Shi-Xun Lu, Jinbin Chen, Dongping Chen, Minshan Chen, and Zhongguo Zhou. "Abstract 1690: Blockade of antitumor milieu-induced tumor cell PIM2 expression potently synergizes with anti-PD-L1 therapy in hepatocellular carcinoma." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-1690.

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Premasiri, A., G. Happawana, and A. Rosen. "Porous Media Tumor Model for Light Penetration and Oxygen Diffusion During Photodynamic Therapy." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-66480.

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Photodynamic therapy (PDT) is an FDA approved, effective, and minimally invasive cancer treatment modality with few side effects. PDT requires three major components; photosensitizing agent, activation light, and molecular oxygen. Optimization of PDT for an individual patient requires good therapeutic selectivity and high efficacy, where the design of such an effective protocol is based on the understanding of the interaction of key therapeutic components with tumor tissue. Tumor models expressive of changes during the growth of tumor along with the behavior of PDT components facilitate the above requirement. In this study we have developed a mathematical model considering tumor as a porous medium of solid of and liquid that enables to express characteristics of a growing tumor. The characteristic lengths and the volumes that can be changed in the model represent the dynamic changes during the growth of the tumor. An energy based light transport model is superimposed with the porous media model to yield an analytical equation of light penetration in turbid media. In addition a molecular diffusion model combined with the porous media tumor model provides a second analytical equation yielding molecular oxygen diffusion during PDT. Experimentally available physiological and photophysical data are used to obtain the results from the developed models. The commonly used wavelength for PDT, 635nm and corresponding photophsical parameters for a healthy tissue are used for the calculations. The modeling results reveal an exponential decay of optical power along the direction of light penetration and the characteristic changes in oxygen diffusion during PDT. Further observations include the time dependent changes in photosensitizer photobleaching and the corresponding increase in oxygen diffusion length. The modeling results in both cases show a promising accordance with the available experimental results in literature. The model calculations also reveal the effect of light penetration on oxygen diffusion in PDT milieu adding to the expression of its usefulness.
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Rappaport, R. S., M. R. Blume, R. L. Vogel, M. H. Levner, and P. P. Hung. "EVIDENCE FOR SYNERGISM BETWEEN TISSUE-TYPE PLASMINOGEN ACTIVATOR AND SINGLE CHAIN UROKINASE ON IN VITRO PLASMA CLOT LYSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642908.

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There is mounting evidence from animal models and the clinic that combination thrombolytic therapy with tissue-type plasminogen activator (tPA) and single chain urokinase (scuPA) is synergistic. Yet, efforts to demonstrate synergism between these two plasminogen activators in vitro have met with discordant results. Collen et al (Thromb. Haemostasis, 56:35, 1986) reported an absence of synergism between these two agents on clot lysis in an in vitro plasma milieu when they were evaluated at molar ratios of 1:4 (tPA:scuPA and vice versa). Gurewich and Pannell (Thromb. Res., 44:217, 1986), however, reported a synergistic effect on fibrin-specific clot lysis in vitro when the agents were combined in concentrations exceeding molar ratios of 1:4 (tPA:scuPA). Here, we present evidence that synergism between tPA and scuPA may be demonstrated in vitro provided that the molar ratio of tPA to scuPA exceeds 1:4 and that the concentration of clot bound or unbound tPA is minimized. In order to achieve this experimental condition, the standard in vitro plasma clot lysis assay was modified. Human plasma clots were incubated first for a short time in plasma containing varying amounts of tPA. After incubation, the clots were washed thoroughly and reimmersed in plasma alone or in plasma containing varying amounts of scuPA or tPA. Under these conditions, lysis proceeded at a greater rate and to a greater extent when tPA clots were immersed in plasma containing an appropriate amount of scuPA than when they were immersed in plasma alone or in plasma containing appropriate amounts of tPA. Lysis of untreated clots or clots exposed first to scuPA and then to plasma containing varying amounts of scuPA proceeded far less efficiently with a characteristic lag. The enhanced lysis produced by tPA and scuPA obeyed the classical definition of synergy: the same biological effect can be obtained with two drugs together at algebraic fractional combinations of less than 1 (Berenbaum, M.C., Clin. Exp. Immunol., 28:1-18, 1977). Thus, conditions that more closely mimic the in vivo situation resulting from a bolus injection of tPA followed by infusion with scuPA, may provide a system for duplication of in vivo synergism in. vi tro and investigation of the mechanism thereof.
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Alves, Emily Tainara Miranda, Lessandra Esper Abdala Gomes, Marine Warmling, and Marcella Beghini Mendes Vieira. "Miller Fisher syndrome secondary to Epstein-Baar virus mononucleosis Emily Tainara Miranda Alves1 , L." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.517.

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Miller Fisher syndrome is a rare variant of Guillain-Barre syndrome and usually presents with at least two of the following features: ataxia, areflexia, and ophthalmoplegia. Male patient, 16 years old, without comorbidities. Odynophagia began, followed by diarrhea and asthenia. Prescribed antibiotic therapy for tonsillitis. After one week hospital admission with neurological examination with mild dysarthria, global grade 5 strength, bilateral naso-index dysmetria, walking gait, positive romberg and areflexia. Tomography and magnetic resonance imaging of normal. Liquor with protein cytological dissociation. Electroneuromyography with absence of H reflex bilaterally, suggestive of demyelinating neuropathy. Abdominal ultrasound with homogeneous splenomegaly. Cervical ultrasonography with prominent reactive looking lymphnodes. Epstein Barr virus Reactive IgM and non-reactive IGG. A diagnostic hypothesis of Miller Fischer syndrome secondary to mononucleosis was raised, despite a negative anti-GQ1B antibody. Immunoglobulin at a dose of 0.4 kg/kg/day was requested. Patient followed immunoglobulin infusion in intensive care unit bed. He was discharged from the hospital, maintaining only mild gait ataxia. Miller Fisher syndrome within the spectrum of Guillain-Barré syndrome occurs due to an aberrant acute autoimmune response to a previous infection, such as the Epstein-Barr virus. Approximately two-thirds of cases are preceded by symptoms of an upper respiratory tract infection or diarrhea. Miller Fisher syndrome is mainly associated with dysfunction of the cranial nerves, but as exemplified in our case, it can occur in its absence. Several studies have suggested that antibodies against gangliosides, anti-GQ1b, are a specific feature, but the absence of antibodies does not exclude the disease. Cerebrospinal fluid shows proteincytological dissociation. Electroneuromyography may show reduced or absent sensory responses. Imaging may be normal or show thickening and enhancement of the spinal nerve roots. Treatment is aimed at supportive care and the therapy of choice is IV immunoglobulin or plasmaphere. Assertive diagnosis associated with early treatment contributes to a favorable clinical response.
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6

Eldor, A., and M. Rose. "RELAPSING THROMBOTIC THROMBOCYTOPENIA PURPURA (TTP): A CLINICAL STUDY OF 38 PATIENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644590.

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A dramatic change in the prognosis of TTP has taken place since the introduction of plasma therapy in 1977. However, plasma therapy does not always result in a complete cure since TTP manifestation may reappear. We describe 38 patients who were treated for TTP in 15 hospitals in Israel and New York City since 1977. 37 patients received plasma (transfusions and exchanges) and 30 survived. 12 patients (37%) developed relapsing TTP. Infections, pregnancy and surgery frequently preceded the initial episodes and the relapses. To evaluate the clinical course of relapsing TTP, a scoring system was developed based on 4 parameters: neurological findings, renal function impairment, platelet count and hemoglobin value at presentation. Each parameter was marked on a scale of 0 to 2: 0= no abnormality, 1= moderate impairment, 2= severe impairment. The severity of each episode was the sum of the 4 scores. The cases were divided into 3 groups: Group A= patients who died during 1st episode; Group B= patients who had only one episode; Group C= patients who relapsed. The following are the average severity scores:The differences between Groups A and B; A and C; B and C; and B and the relapses are significant (p<0.005)(Chi-square test). The differences between Group C first episode* and subsequent relapses are not significant (paired t-test). Hence, relapsing TTP was manifested by a milder clinical course, however two relapses were fatal, demonstrating that this is not a benign disorder. Therapy consisted of plasma, plasmapheresis, steroids, platelet-inhibitor drugs and 11 patients underwent splenectomy. Addition of vincristin seemd to shorten the duration of the TTP episode. No differences were observed in the treatment of Group A, B and C patients. However, during relapses, patients received less therapy probably due to their milder clinical course. Splenectomy did not prevent relapses, but prolonged the remission duration. Based on our data, we recommend that the severity score be used in determining the intensity of treatment.
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7

Silva Júnior, Mário Luciano de Mélo, Roberta Lorena de Farias Souza, Marcos Vinícius de Souza Vilanova, and Marcos Holmes Carvalho. "Subacute combined degeneration of spinal cord vs Miller-Fisher syndrome: a diagnostic challenge." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.635.

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Context: Ataxic syndromes in the emergency department have a vast differential diagnosis, including immune, nutritional, and other etiologies. Case report: Man, 67yo, alcoholic, but previously healthy, came to ED due to complaints of falls and progressive dysesthesia in lower limbs which started 7 days from admission. He denied other toxic exposures or infectious history, except covid-19 one month before the current symptoms. Physical examination revealed mild hoarseness, left hemipalate paresis, tactile and position sense hypoesthesia, no sensory level, absence of profound reflexes; right hypotonia, global ataxia, and he was unable to walk. Neuroaxis MRI was normal. CSF obtained at D10 had 2 lymphocytes/mm3, 96mg/dL of proteins and no other abnormalities. Hb=13g/ dL, VCM=103fL, B12=424pg/mL, LDH and homocysteine were high. Negative anti-HTLV and -transglutaminase; covid-19 rapid test was positive, but rt-PCR was negative. ENMG revealed moderate sensory-motor axonal polyneuropathy. We hypothesized that the main differential diagnoses were subacute combined degeneration of spinal cord (although high level of protein in CSF) and Miller-Fisher syndrome (although ophthalmoparesis was absent). Considering that there was no motor nor respiratory symptoms, we did not offer pulse therapy and opted for B12 vitamin replacement. The patient had a favorable response to therapies and was able to walk at two weeks of treatment. Conclusions: We did not define the etiology of this case, however, it is important to keep B12 deficiency in mind (even when it is into the lab reference range) and to pay attention to post-viral atypical manifestations, mostly in the context of the current covid-19 pandemic.
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Zambon, G., M. Vigo, M. Scatigna, C. Di Giacomo, and P. Prandoni. "LOW MOLECULAR-WEIGHT HEPARIN CY216 IN THE TREATMENT OF ACUTE MASSIVE PULMONARY EMBOLISM." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643234.

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A 68 years old women presented to our Department with signs and symptoms suggestive of acute massive pulmonary embolism twenty days after knee fracture. She was in shock: heart rate, respiratory rate and blood pressure was 140/m, 36/m and 70 mmHg respectively. Two months before she had a severe episode of cerebral haemorrhage. Clinical suspicion was confirmed by a pulmonary digital subtraction angiography (DSA) and computerized tomography (CT), which showed a large filling defect in the right main pulmonary artery and a high degree of fascular sequestration of the lung (Miller index = 18). After rejecting the use of thrombolytic drugs, it was decided to treat the patient with low molecular-weight heparin CY216, due to the possible weaker bleeding potential with respect to the unfractionated heparin, and a dose of 17,500 U anti-Xa Choay was administered subcutaneously two times daily. A significant clinical improvement (decrease of heart and respiratory rate and increase of blood pressure) was observed within the first 48 hours of treatment. Pulmonary DSA and CT scan, repeated after 7 days of treatment, showed an important reduction of the above-mentioned defects (Miller index = 7). Not any bleeding complication developed and the patient was discharged within 15 days from the Hospital on warfarin therapy.
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9

Villares de Carvalho, Igor, and David de Souza Brito. "PERMANÊNCIAS RURAIS NO RECIFE: espaço, tempo e análise da arquitetura rural remanescente." In Seminario Internacional de Investigación en Urbanismo. Universitat Politècnica de Catalunya, Grup de Recerca en Urbanisme, 2024. http://dx.doi.org/10.5821/siiu.12676.

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This article presents the preliminary outcomes of an ongoing research endeavor in which we initially delve into foundational concepts aimed at comprehending the urban landscape, while considering the rural structures within this milieu. These conceptual underpinnings encompass space, time, and landscape. Following the establishment of this foundational understanding, we progress to gather records and data archived within municipal and state institutions, spanning the period from 1875 to 2014. These records encapsulate diverse temporal situations, thereby enabling a historical analysis of the integration of rural life into the urban environment and how this interplay contributes to a nuanced comprehension of the territory of the city of Recife. Keywords: space, rural, urban, territory. Este artigo apresenta os resultados parciais de uma pesquisa em andamento onde primeiramente exploramos os conceitos fundamentais para compreender o cenário urbano, considerando as estruturas rurais presentes nesse ambiente. Estes conceitos incluem espaço, tempo e paisagem. Após solidificar essa compreensão, avançamos para a coleta de registros e dados arquivados em instituições municipais e estaduais, abrangendo o período de 1875 a 2014. Estes registros capturam diversas situações ao longo do tempo, permitindo uma análise histórica da integração da vida rural ao ambiente urbano e como essa interação contribui para uma compreensão aprofundada do território da cidade do Recife. Palavras-chave: espaço, rural, urbano, território.
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Veeramani, Vivekanand, Ramanathan Karthi, and Muthu Shanmugam Ramakrishnan. "Model Based Charge Control for 3-Cylinder TGDI Miller Engine Containing Variable Geometry Turbocharger." In Symposium on International Automotive Technology. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2024. http://dx.doi.org/10.4271/2024-26-0043.

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<div class="section abstract"><div class="htmlview paragraph">For ensuring environmental safety, strong emphasis on CO<sub>2</sub> pollution reduction is mandated which led to evolution of miller cycle engines.</div><div class="htmlview paragraph">However, the inherent Miller engine characteristic is the lower volumetric efficiency when compared to otto engines because of which small turbo chargers with variable geometry turbines are used to induct air into the engine. With miller engine and VGT turbo charger combination arises the challenges of charge controllability because of lower inertia and reduced vane control area. With conventional turbo charger control methods, the response time is slow thereby leading to turbo lag or severe over boosting, this is overcome by accurate engine modelling and using the same as input for charger control.</div><div class="htmlview paragraph">In this study, model-based calibration approach was performed on a 3-cylinder Miller GDI 1.2L engine to model the charge exchange of the engine and use the same for determination required turbine vane positions to achieve the desired airflow induction into the engine. The charge exchange model consists of two components namely compressor model and the turbine model. Compressor model predicts the air induction into the engine by virtue of the power provided by the turbine and trajectory of compressor speed. The compressor speed trajectory is determined as a function of compressor inertia and the pressure upstream and downstream of compressor. The Turbine modelling involves accurately modelling the exhaust pressure and temperature across the turbine and deriving the turbine power and Vane position required to achieve the desired pressure at compressor. In addition to this, better surge, and compressor overspeed prediction is possible.</div><div class="htmlview paragraph">Results show that with model-based turbo control mechanism, efficient control of airflow induction is possible with reduced turbo lag. Additionally Model based calibration approach reduces Calibration Effort for Variants using Same Turbo charger.</div></div>
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