Journal articles: 'Migraine with aura'

1

Reuter, U., MS Del Rio, H.-C. Diener, G. Allais, B. Davies, A. Gendolla, J. Pfeil, S. Schwalen, B. Schäuble, and J. van Oene. "Migraines with and without aura and their response to preventive therapy with topiramate." Cephalalgia 30, no. 5 (October 1, 2009): 543–51. http://dx.doi.org/10.1111/j.1468-2982.2009.01999.x.

Full text

Abstract:

Data from the Prolonged Migraine Prevention (PROMPT) with Topiramate trial were evaluated post hoc to determine whether topiramate could prevent migraine auras, and whether its efficacy in preventing migraine headaches was similar in patients with (MA; n = 269) and without (MoA; n = 542) aura. Migraines and auras were recorded during prospective baseline, 6-month open-label (OL) topiramate and 6-month double-blind (DB), placebo-controlled phases. In the last 28 OL days, migraines without aura and migraine auras decreased by 43.1% and 54.1%, respectively, in MA patients. MoA patients experienced a 44.3% reduction in migraines. In the DB phase, increases in migraines with placebo vs. topiramate were similar to the full study, but were generally not statistically significant, probably due to lack of power in the subgroup analysis. Similarly, there were no statistically significant changes in number of auras between groups. Thus, topiramate appears to reduce migraine auras in parallel with headache reductions, which are similar in patients with and without aura.

APA, Harvard, Vancouver, ISO, and other styles

2

Yamanaka, Gaku, Soken Go, Shinichiro Morichi, Mika Takeshita, Natsumi Morishita, Shinji Suzuki, Takamatsu Tomoko, et al. "Clinical Features and Burden Scores in Japanese Pediatric Migraines With Brainstem Aura, Hemiplegic Migraine, and Retinal Migraine." Journal of Child Neurology 35, no. 10 (June 1, 2020): 667–73. http://dx.doi.org/10.1177/0883073820927840.

Full text

Abstract:

Background: Migraines are a broad spectrum of disorders classified by the type of aura with some requiring attentive treatment. Vasoconstrictors, including triptans, should be avoided in the acute phase of migraines with brainstem aura, in hemiplegic migraine, and in retinal migraine. This study investigated the characteristics and burden of these migraines. Methods: Medical charts of 278 Japanese pediatric patients with migraines were retrospectively reviewed. Migraine burden of migraines with brainstem aura, hemiplegic migraines, and retinal migraine was assessed using the Headache Impact Test-6™ (HIT-6) and the Pediatric Migraine Disability Assessment scale (PedMIDAS). Results: Of 278 patients screened, 12 (4.3%) patients with migraines with brainstem aura (n = 5), hemiplegic migraines (n = 2), and retinal migraine (n = 5) were enrolled in the study. All patients had migraine with/without typical aura, whereas some patients had coexisting migraine with another type of headache (chronic tension-type headache in 3 patients, and 1 each with frequent episodic tension-type headache, headache owing to medication overuse, and chronic migraine). Migraines with brainstem aura, hemiplegic migraines, and retinal migraine patients with coexisting headaches had higher HIT-6 or PedMIDAS scores, whereas migraines with brainstem aura, hemiplegic migraines, and retinal migraine patients without coexisting headache did not show high HIT-6 or PedMIDAS scores. Conclusion: All migraines with brainstem aura, hemiplegic migraines, and retinal migraine patients experienced migraine with or without typical aura, and some patients having other coexisting headaches also had high PedMIDAS and HIT-6 scores. PedMIDAS and HIT-6 should not be considered diagnostic indicators of migraines with brainstem aura, hemiplegic migraines, or retinal migraine. In clinical practice for headaches in children, careful history taking and proactive assessment of the aura are needed for accurate diagnosis of migraines with brainstem aura, hemiplegic migraines, and retinal migraine.

APA, Harvard, Vancouver, ISO, and other styles

3

Akiyama, Osamu, Akihide Kondo, and Iwao Akiyama. "Paediatric migraine with visual hallucination auras appearing in the form of a human body." BMJ Case Reports 12, no. 12 (December 2019): e232358. http://dx.doi.org/10.1136/bcr-2019-232358.

Full text

Abstract:

The most common type of migraine aura is multifaceted visual aura, such as scintillating scotoma or geometrical patterns, visual hallucinations in which a physical body is extremely rare. We report a paediatric case of migraine in which visual hallucinations appeared as auras in the form of a human body. The patient was an 11-year-old girl suffering from migraine with curious visual aura. The auras were atypical visual hallucinations that were sometimes accompanied by auditory hallucinations. Approximately 5–20 min before the headache, the patient would see a middle-aged man wearing sunglasses in her field of vision. Acetaminophen (10 mg/kg) and Japanese herbal medicine administered when necessary effectively treated the headaches. Finally, the patient was no longer complaining of her hallucination auras. Although the pathophysiology of migraines accompanied by auras is unclear, it appears that cerebral blood flow and cortical spreading depression are involved in auras.

APA, Harvard, Vancouver, ISO, and other styles

4

Russell, MB, HK Iversen, and J. Olesen. "Improved Description of the Migraine Aura by a Diagnostic Aura Diary." Cephalalgia 14, no. 2 (April 1994): 107–17. http://dx.doi.org/10.1046/j.1468-2982.1994.1402107.x.

Full text

Abstract:

We present a diagnostic aura diary for prospective recordings of migraine with aura. Three questionnaires are supplemented with sheets for drawings and plottings of visual and sensory auras. Twenty patients recorded 54 attacks of migraine with aura and 2 attacks of migraine aura without headache. The visual and sensory aura were usually gradually progressive, reaching maximum development in 15 and 25 min (median) respectively and had a total duration of 20 and 55 min (median) respectively. Approximately 13% of the attacks had acute onset of visual aura associated with other features more typical of migraine. The visual and sensory auras always preceded typical migraine headache, and headache occurring before aura symptoms was always of the tension type, The migraine headache was milder than in attacks of migraine without aura and often did not have migraine characteristics. In attacks with unilateral head pain, headache and aura symptoms were contralateral in 90% and ipsilateral in 10%.

APA, Harvard, Vancouver, ISO, and other styles

5

Quliti, Khalid Al. "Migraine without Aura Correlation with Anxiety Level and Socio- Demographic Characteristics." Pakistan Journal of Medical and Health Sciences 16, no. 2 (February 26, 2022): 578–82. http://dx.doi.org/10.53350/pjmhs22162578.

Full text

Abstract:

Purpose: Different types of migraine may be studied separately to understand their epidemiology and pathophysiology better. No studies have investigated patients with associated factors of anxiety severity in migraine without auras. Therefore, in this study, anxiety and its associated factors were investigated in a sample of Saudi Arabian patients with migraine without aura. Methods: A cross-sectional study of 122 conveniently sampled migraine patients at Madinah hospitals, Saudi Arabia, completed the Generalized anxiety disorder-7 scale (GAD-7), and a tool for social, demographics, and clinical information. Results: The majority of patients who did not have an aura with their migraine were female (67.2%); many did not report participating in sports activities (58.2%), or have a family history of migraine-headaches (74.6%). Anxiety severity was higher in migraine-without-aura patients, and those undergoing treatment for co-morbid conditions (β = .547, p = .042), those without family history of migraine/chronic headache (β = .016, p = .016), and patients with high frequency of migraine medication use (β = .009, p = .009). Discussion: The correlation of the anxiety severity level in patients who have migraines without aura may have important clinical, and epidemiological implications. females with their change in hormonal stat have a higher prevalence of migraine without aura, those with no habitual sport activity, and family history of migraine may indicate the need for targeted screening for migraine in these groups. Keywords: migraine; headache; sports; family history; trauma; GAD

APA, Harvard, Vancouver, ISO, and other styles

6

Charles, Andrew, and Jakob Møller Hansen. "Migraine aura." Current Opinion in Neurology 28, no. 3 (June 2015): 255–60. http://dx.doi.org/10.1097/wco.0000000000000193.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Goadsby, Peter J. "Migraine Aura." Neuron 41, no. 5 (March 2004): 679–80. http://dx.doi.org/10.1016/s0896-6273(04)00112-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Cutrer, F. Michael, and Karina Huerter. "Migraine Aura." Neurologist 13, no. 3 (May 2007): 118–25. http://dx.doi.org/10.1097/01.nrl.0000252943.82792.38.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Frank, Florian, Martin Faulhaber, Karl Messlinger, Chiara Accinelli, Marina Peball, Alois Schiefecker, Katharina Kaltseis, Martin Burtscher, and Gregor Broessner. "Migraine and aura triggered by normobaric hypoxia." Cephalalgia 40, no. 14 (August 13, 2020): 1561–73. http://dx.doi.org/10.1177/0333102420949202.

Full text

Abstract:

Background For future experimental studies or the development of targeted pharmaceutical agents, a deeper insight into the pathophysiology of migraine is of utmost interest. Reliable methods to trigger migraine attacks including aura are desirable to study this complex disease in vivo. Methods To investigate hypoxia as a trigger for migraine and aura, we exposed volunteers diagnosed with migraine, with (n = 16) and without aura (n = 14), to hypoxia utilizing a hypoxic chamber adjusted to a FiO2 of 12.6%. The occurrence of headache, migraine, aura, and accompanying symptoms were registered and vital signs were collected for 6 hours under hypoxia and 2 hours of follow-up. A binary logistic regression analysis examined the probability of triggering headaches, migraines, aura, photo- and phonophobia. Findings Of 30 participants, 24 (80.0%) developed headaches and 19 (63.3%) migraine, five (16.7%) reported aura. Two patients that developed aura never experienced aura symptoms before in their life. The increase of mean heart frequency was higher in patients developing headaches or migraine. Mean SpO2 during hypoxia was 83.39%. Conclusion Hypoxia was able to trigger migraine attacks and aura independently of any pharmacological agent.

APA, Harvard, Vancouver, ISO, and other styles

10

Di Stefano, Francesca, Gianluca Floris, Mariangela Vacca, Giulia Serra, Antonino Cannas, Giuseppe Borghero, Maria Giovanna Marrosu, and Francesco Marrosu. "Transient unilateral spatial neglect during aura in a woman with sporadic hemiplegic migraine." Cephalalgia 33, no. 14 (May 14, 2013): 1194–97. http://dx.doi.org/10.1177/0333102413487446.

Full text

Abstract:

Background Hemiplegic migraine is a rare form of migraine with aura characterized by motor aura. Although auras in hemiplegic migraine are typically complex with two or more aura symptoms, neglect has been rarely described. Case report We report the case of a 20-year-old woman with sporadic hemiplegic migraine that was investigated for the presence of unilateral spatial neglect (USN) during aura in one of her migraine attacks. Transient hemispatial neglect was observed during a right-sided migraine attack with left sensory-motor hemisyndrome; after migraine resolution there was a total recovery. Conclusions Our case demonstrates that USN may be a symptom of aura. To our knowledge, this is the first report of USN during aura in an adult with sporadic hemiplegic migraine.

APA, Harvard, Vancouver, ISO, and other styles

11

Petrusic, Igor, Michele Viana, Marko Dakovic, Peter J Goadsby, and Jasna Zidverc-Trajkovic. "Proposal for a Migraine Aura Complexity Score." Cephalalgia 39, no. 6 (November 20, 2018): 732–41. http://dx.doi.org/10.1177/0333102418815487.

Full text

Abstract:

Objectives Currently, there is no scoring system for assessing the complexity of migraine aura. Our goal was to develop a Migraine Aura Complexity Score that synthesizes the quantity and quality of aura symptoms and to test its applicability in neuroimaging studies. Methods Patients with migraine aura were interviewed in order to obtain characteristics of migraine aura. Explorative and confirmatory analyses were used to develop the Migraine Aura Complexity Score. Median values were derived from 10 consecutive migraine auras in each patient. The Migraine Aura Complexity Score was correlated with an average cortical thickness of different brain areas in studied patients. The Surface-based Morphometric Analysis approach was used to estimate cortical thickness. Results This study included 23 (16 females and seven males) migraineurs with aura. Confirmatory factor analysis suggested the second-order model with three-factor measurement for grading migraine aura. The first factor is linked to higher cortical dysfunction during migraine aura, while the second is associated with the degree of involvement of primary visual and somatosensory cortices; the third linked symptoms of somatosensory aura and hand and head involvement. Positive correlation of Migraine Aura Complexity Score and averaged cortical thickness were found in the left and right hemispheres overall (r = 0.568, p = 0.007; r = 0.617, p = 0.003) and in some of their regions. Conclusions This study demonstrates that the Migraine Aura Complexity Score could be a valuable tool for assessing migraine aura. The score could be used in neuroradiological studies in order to achieve a stratification of patients with migraine aura.

APA, Harvard, Vancouver, ISO, and other styles

12

Spierings, Egilius L. H. "Flurries of Migraine (With) Aura and Migraine Aura Status." Headache: The Journal of Head and Face Pain 42, no. 4 (April 2002): 326–27. http://dx.doi.org/10.1046/j.1526-4610.2002.42402.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Allais, Gianni, Margarita Sanchez del Rio, Hans-Christoph Diener, Chiara Benedetto, Joop Pfeil, Barbara Schäuble, and Joop van Oene. "Perimenstrual migraines and their response to preventive therapy with topiramate." Cephalalgia 31, no. 2 (July 22, 2010): 152–60. http://dx.doi.org/10.1177/0333102410378049.

Full text

Abstract:

Introduction: Preventive treatment with topiramate is effective for overall reduction of migraine frequency, but there are few data regarding its efficacy on perimenstrual migraines. To determine whether topiramate can prevent perimenstrual migraines, we analyzed data from premenopausal women as a subgroup of the Prolonged Migraine Prevention with Topiramate (PROMPT) study. Methods: In total, 198 women from the PROMPT study with menstrually related migraine (MRM) were evaluated. After a one-to-two–month prospective baseline period, patients received open-label topiramate (50–200 mg/day) for six months. Results: During topiramate treatment, mean monthly migraine frequency was reduced from 7.03 at baseline to 4.36 (mean change: −2.66; p < .001, endpoint analysis). Mean percentage reductions were similar for migraines during and outside the perimenstrual period (−45.9% and −46.1%, respectively). In patients with aura, reductions in migraine days with (−48.3%) or without (−43.4%) aura were similar to those in patients without aura (−45.4%). Reductions were also similar whether women were taking combined oral contraceptives (−47.0%) or were not (−46.6%). Conclusions: Topiramate reduces the frequency, but not severity or duration, of perimenstrual migraines in women with MRM, including migraines with and without aura, and regardless of combined oral contraceptive use.

APA, Harvard, Vancouver, ISO, and other styles

14

Singla, Monika, Richa Kale, Jaisal Brar, and Sanskriti Bhardwaj. "Visual Aura in Migraine: An Analysis of 165 Patients in a Tertiary Care Hospital in North India." Journal of Neurosciences in Rural Practice 12, no. 02 (March 3, 2021): 273–80. http://dx.doi.org/10.1055/s-0040-1721624.

Full text

Abstract:

Abstract Background Migraine auras are transient neurological symptoms, usually lasting for approximately 5 to 30 minutes before the onset of migraine pain. Out of various types of auras, visual aura is the commonest and has variable manifestations, forming approximately 90% of auras. These visual auras may be of particular interest to the ophthalmologist as well as to the neurologist. We planned to conduct this study to look for the prevalence of visual aura in our population and make a descriptive analysis of the same. Materials and Methods It was an observational, questionnaire-based cross-sectional study, enrolling all the consenting patients of migraine. Migraine was classified by International Classification of Headache Disorders (ICHD)-III β version, Third edition of International Classification of Headache Disorders. Patients in whom aura was present, detailed profile of visual aura was made regarding its type, duration, relation with migraine as per its laterality, etc. Observations and Results Out of 1,245 migraine patients, 165 (13.25%) patients reported to have visual aura, 127 females and 38 males. Scintillating scotoma was the commonest type of visual aura, then zigzag lines, blurred vision, and tunnel vision. Majority of patients had aura between 5 and 35 minutes, none had more than 60 minutes. A total of 142 patients out of 165 had unilateral aura, out of which 64 (38.78%) patients had aura ipsilateral to the side of headache, and 78 (47.27%) patients had aura contralateral to the side of headache. Twenty-three (13.93%) patients had bilateral aura. Discussion The frequency of visual aura was found to be 13.25% in our study, which is high compared with previously published Indian data. We did a descriptive analysis of visual aura symptoms. Conclusion Visual aura is the commonest type of aura, more frequent in females. Scintillating scotoma was found to be the commonest type of visual aura, followed by zigzag lines in study. Our study is unique of its type as its shows a descriptive visual analysis in a larger number of patients.

APA, Harvard, Vancouver, ISO, and other styles

15

Viana, Michele, Grazia Sances, Mattias Linde, Natascia Ghiotto, Elena Guaschino, Marta Allena, Salvatore Terrazzino, Giuseppe Nappi, Peter J. Goadsby, and Cristina Tassorelli. "Clinical features of migraine aura: Results from a prospective diary-aided study." Cephalalgia 37, no. 10 (August 29, 2016): 979–89. http://dx.doi.org/10.1177/0333102416657147.

Full text

Abstract:

Background A detailed evaluation of migraine aura symptoms is crucial for classification issues and pathophysiological discussion. Few studies have focused on the detailed clinical aspects of migraine aura. Methods We conducted a prospective diary-based study of migraine aura features including presence, quality, laterality, duration of each aura symptom, their temporal succession; presence of headache and its temporal succession with aura. Results Seventy-two patients completed the study recording the characteristics of three consecutive auras ( n = 216 auras). Visual symptoms occurred in 212 (98%), sensory symptoms in 77 (36%) and dysphasic symptoms in 22 (10%). Most auras had more than one visual symptom (median 2, IQR 1–3, range 1–4). The majority of patients (56%) did not report a stereotyped aura on the three attacks with respect to visual features, the combination and/or temporal succession of the three aura symptoms. Fifty-seven percent of patients also reported a different scenario of temporal succession between aura and headache in the three attacks. Five per cent of aura symptoms were longer than four hours. Conclusion These findings show a high inter- and intravariability of migraine with aura attacks. Furthermore, they provide reliable data to enrich and clarify the spectrum of the aura phenotype.

APA, Harvard, Vancouver, ISO, and other styles

16

Sen, Souvik, X. Michelle Androulakis, Viktoriya Duda, Alvaro Alonso, Lin Yee Chen, Elsayed Z. Soliman, Jared Magnani, et al. "Migraine with visual aura is a risk factor for incident atrial fibrillation." Neurology 91, no. 24 (November 14, 2018): e2202-e2210. http://dx.doi.org/10.1212/wnl.0000000000006650.

Full text

Abstract:

ObjectiveMigraine with visual aura is associated with cardioembolic stroke risk. The aim of this study was to test association between migraine with visual aura and atrial fibrillation (AF), in the Atherosclerosis Risk in Communities study.MethodsIn the Atherosclerosis Risk in Communities study, a longitudinal, community-based cohort study, participants were interviewed for migraine history in 1993–1995 and were followed for incident AF through 2013. AF was adjudicated using ECGs, discharge codes, and death certificates. Multivariable Cox proportional hazards models were used to study the relation between migraine and its subtypes with incident AF, compared with controls without headaches. Mediation analysis was conducted to test whether AF was a mediator of migraine with visual aura-associated stroke risk.ResultsOf 11,939 participants assessed for headache and without prior AF or stroke, 426 reported migraines with visual aura, 1,090 migraine without visual aura, 1,018 nonmigraine headache, and 9,405 no headache. Over a 20-year follow-up period, incident AF was noted in 232 (15%) of 1,516 with migraine and 1,623 (17%) of 9,405 without headache. After adjustment for multiple confounders, migraine with visual aura was associated with increased risk of AF compared to no headache (hazard ratio 1.30, 95% confidence interval 1.03–1.62) as well as when compared to migraine without visual aura (hazard ratio 1.39, 95% confidence interval 1.05–1.83). The data suggest that AF may be a potential mediator of migraine with visual aura–stroke risk.ConclusionsMigraine with aura was associated with increased risk of incident AF. This may potentially lead to ischemic strokes.

APA, Harvard, Vancouver, ISO, and other styles

17

Lucas, C. "Migraine with aura." Revue Neurologique 177, no. 7 (September 2021): 779–84. http://dx.doi.org/10.1016/j.neurol.2021.07.010.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Charles, Andrew. "The Migraine Aura." CONTINUUM: Lifelong Learning in Neurology 24, no. 4 (August 2018): 1009–22. http://dx.doi.org/10.1212/con.0000000000000627.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Lipton, R. B., and C. A. Derby. "Migraine with aura." BMJ 337, aug07 1 (August 7, 2008): a745. http://dx.doi.org/10.1136/bmj.a745.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Prakash, Sanjay, Anurag Prakash, and Deepali Lodha. "Bilateral persistent ophthalmoplegia in a patient with migraine: persistent migraine aura without infarction?" BMJ Case Reports 14, no. 4 (April 2021): e242099. http://dx.doi.org/10.1136/bcr-2021-242099.

Full text

Abstract:

Migraine auras typically last for 5–60 min. An aura that persists for more than a week without evidence of infarction on neuroimaging is called persistent aura without infarction. Persistent migraine aura without infarction is usually described with visual auras. Herein, we are reporting a 24-year-old man who had an attack of a headache with diplopia, vertigo and tinnitus. Tinnitus and vertigo disappeared within 30 min. The headache also disappeared within 6 hours. However, diplopia and ophthalmoplegia persisted for 4 weeks. Secondary causes of bilateral ophthalmoplegia were ruled out by a proper history, clinical examinations and appropriate investigations. A trial with lamotrigine and sodium valproate led to the complete improvement in ophthalmoplegia within 2 weeks. We considered ophthalmoplegia in this patient as ‘persistent brainstem aura without infarction’. We suggest that a possibility of persistent migraine aura without infarction should be considered in all migraineurs who have unexplained and persistent neurological symptoms.

APA, Harvard, Vancouver, ISO, and other styles

21

Dai, Lingling, Qiang Xu, Xing Xiong, Yang Yu, Ximing Wang, Hui Dai, Hongru Zhao, and Jun Ke. "Propagation Structure of Intrinsic Brain Activity in Migraine without Aura." Brain Sciences 12, no. 7 (July 10, 2022): 903. http://dx.doi.org/10.3390/brainsci12070903.

Full text

Abstract:

Previous studies have revealed highly reproducible patterns of temporally lagged brain activity in healthy human adults. However, it is unknown whether temporal organization of intrinsic activity is altered in migraines or if it relates to migraine chronification. In this resting-state functional magnetic resonance imaging study, temporal features of intrinsic activity were investigated using resting-state lag analysis, and 39 episodic migraine patients, 17 chronic migraine patients, and 35 healthy controls were assessed. Temporally earlier intrinsic activity in the hippocampal complex was revealed in the chronic migraine group relative to the other two groups. We also found earlier intrinsic activity in the medial prefrontal cortex in chronic compared with episodic migraines. Both migraine groups showed earlier intrinsic activity in the lateral temporal cortex and sensorimotor cortex compared with the healthy control group. Across all patients, headache frequency negatively correlated with temporal lag of the medial prefrontal cortex and hippocampal complex. Disrupted propagation of intrinsic activity in regions involved in sensory, cognitive and affective processing of pain may contribute to abnormal brain function during migraines. Decreased time latency in the lateral temporal cortex and sensorimotor cortex may be common manifestations in episodic and chronic migraines. The temporal features of the medial prefrontal cortex and hippocampal complex were associated with migraine chronification.

APA, Harvard, Vancouver, ISO, and other styles

22

Russell, M. B., J. Hilden, S. A. Sorensen, and J. Olesen. "Familial occurrence of migraine without aura and migraine with aura." Neurology 43, no. 7 (July 1, 1993): 1369. http://dx.doi.org/10.1212/wnl.43.7.1369.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Russell, MB, L. Iselius, and J. Olesen. "Migraine Without Aura and Migraine with Aura are Inherited Disorders." Cephalalgia 16, no. 5 (August 1996): 305–9. http://dx.doi.org/10.1046/j.1468-2982.1996.1605305.x.

Full text

Abstract:

The familial occurrence and mode of inheritance were analysed in families with migraine without aura (MO) and migraine with aura (MA). The probands were found among 4000 persons from the general population. All persons with MA were included as probands, and an equivalent number of probands with MO was selected as a random sample among those with MO. Spouses and first-degree relatives were blindly interviewed. All interviews were performed by one neurological research fellow. The distinct familial patterns indicate that MO and MA have a different aetiology. Compared with the general population, the first-degree relatives of probands with MO had a 1.9-fold increased risk of MO while spouses had a 1.5-fold increased risk of MO, indicating that both genetic and environmental factors are important in MO. The first-degree relatives of probands with MA had a four-fold increased risk of MA while spouses had no increased risk of MA, indicating that MA is determined largely by genetic factors. The complex segregation analysis indicate that both MO and MA have multifactorial inheritance without generational difference.

APA, Harvard, Vancouver, ISO, and other styles

24

Rasmussen, Birthe Krogh, and Jes Olesen. "Migraine With Aura and Migraine Without Aura: An Epidemiological Study." Cephalalgia 12, no. 4 (August 1992): 221–28. http://dx.doi.org/10.1046/j.1468-2982.1992.1204221.x.

Full text

Abstract:

In a cross-sectional study of headache disorders in a representative general population of 1,000 persons the epidemiology of migraine with aura (MA) and migraine without aura (MO) was analysed in relation to sex and age distribution, symptomatology and precipitants. The headache disorders were classified on the basis of a clinical interview as well as a physical and a neurological examination using the operational diagnostic criteria of the International Headache Society (IHS). Lifetime prevalence of MA was 5%, male:female ratio 1:2. Lifetime prevalence of MO was 8%, M:F ratio 1:7. Women, but not men, were significantly more likely to have MO than MA. Neither MA nor MO showed correlation to age in the studied age interval (25–64 years). Premonitory symptoms occurred in 16% of subjects with MA and in 12% with MO. One or more precipitating factor was present in 61% with MA and in 90% with MO. In both MA and MO the most conspicuous precipitating factor was stress and mental tension. Visual disturbances were the most common aura phenomenon occurring in 90% of subjects with MA. Aura symptoms of sensory, motor or speech disturbances rarely occurred without coexisting visual disturbances. The pain phase of MA fulfilled the criteria for MO of the IHS. Headache was, however, less severe and shorter lasting in MA than in MO. Onset at menarche, menstrual precipitation, menstrual problems, influence of pregnancy and use of oral contraceptives all showed some relationship with the presence of MO and less with MA. The present findings suggest that MA and MO share the pain phase. Among subjects with MA and MO, 50% and 62%, respectively, had consulted their general practitioner because of migraine. Selection bias in previous clinical studies is demonstrated by comparisons with the present unselected sample.

APA, Harvard, Vancouver, ISO, and other styles

25

Russell, Michael Bjørn, and Jes Olesen. "The Genetics of Migraine Without Aura and Migraine With Aura." Cephalalgia 13, no. 4 (August 1993): 245–48. http://dx.doi.org/10.1046/j.1468-2982.1993.1304245.x.

Full text

Abstract:

Studies of twins, spouses and familial aggregation strongly suggest that migraine without aura (MO) and migraine with aura (MA) are genetically determined. The mode of inheritance is most likely multifactorial in both MO and MA. However, autosomal dominant inheritance with reduced penetrance cannot be excluded in either MO or MA. At present the only evidence for genetic heterogeneity of MA is familial hemiplegic migraine with slowly progressive ataxia. This phenomenon can also be explained by linkage of different genes. All existing studies have been characterized by one or more of the following methodologic shortcomings: selection of probands from clinic populations, information obtained by questionnaire, family history obtained through probands, insufficient description of the attacks, lack of distinction between MO and MA. Useful strategies for future studies of migraine genetics are discussed.

APA, Harvard, Vancouver, ISO, and other styles

26

Almohammadawi, Khalid Obiad Mohsin, Haider Saadoon Qasim Alhilfi, and Rafid Adil Abood Alkhalidy. "Clinical characteristics of migraine: A prospective cross-sectional study over nine years." F1000Research 7 (December 24, 2018): 1973. http://dx.doi.org/10.12688/f1000research.16854.1.

Full text

Abstract:

Background: Migraine is the most common primary headache. This study aimed to describe clinical observations about migraine in outpatients in Iraq, including migraine types and subtypes, duration and frequency of acute attacks, severity, disability, effects on the quality of life, and complications. Methods: This is an outpatient-based prospective cross-sectional study, conducted in the Misan province, Iraq over nine years, and included 1412 patients aged 12 to 50 years. The data was collected from clinical records of patients who attended outpatient clinics. Results: The study included 1100 women (77.9%) and 312 men (22.1%); the women/men ratio being 3.5:1. The median age and standard deviation (SD) was 21 ± 5.42 years. The mean age at first attack of migraine was 17 ± 4.91 years. Migraine without aura was the most common type, accounting for 68% of the cases. The mean frequency of the attacks was (2 ± 4.63) days/month. In general, acute attacks were moderate to severe. Conclusions: In our study, we observed that migraine causes a headache resulting in episodes of temporary functional disability and women suffered more than men (ratio of 3.5:1). The mean age at first attack was a young age, and a family history of migraine highly altered distribution. Migraine without aura was the most common type, and symptoms including nausea and vomiting and photophobia were experienced by patients, which were used to diagnose migraines. Experienced aura was the most common migraine with aura, but also aura without a headache and aura with migraine were prevalent; therefore, it is important to differentiate between migraine subtypes. Visual aura was the most common aura, while motor symptoms were very rare. Chronic persistent headaches were a common complication recorded. These features provide evidence for the creation of screening tools in migraine prevention migraine.

APA, Harvard, Vancouver, ISO, and other styles

27

Lampl, C. "Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura." Journal of Neurology, Neurosurgery & Psychiatry 76, no. 12 (December 1, 2005): 1730–32. http://dx.doi.org/10.1136/jnnp.2005.063750.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Park, Jeong-Jin, Soo Jeong Kim, Hahn Young Kim, Hong Gee Roh, and Dong Wook Kim. "Migraine with Aura as a Stroke Mimic." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 47, no. 2 (October 28, 2019): 242–44. http://dx.doi.org/10.1017/cjn.2019.316.

Full text

Abstract:

ABSTRACT:Migraine with aura is one of the causes of stroke mimics. We retrospectively reviewed the 10-year medical records of patients who were treated with acute stroke management protocol. We analyzed the frequency and characteristics of patients with a final diagnosis of migraine with aura. Among the 1355 patients with stroke mimics, migraine with aura was the final diagnosis in 36 patients (2.7%). The most common auras included sensory and brainstem auras followed by motor, visual, and speech/language auras. One patient manifested transient atrial fibrillation during the migraine attack, which can be a link with acute stroke.

APA, Harvard, Vancouver, ISO, and other styles

29

Evers, S., B. Homann, and J. Vollmer. "Agraphia as the Only Symptom of Migraine Aura." Cephalalgia 16, no. 8 (December 1996): 562–63. http://dx.doi.org/10.1046/j.1468-2982.1996.1608562.x.

Full text

Abstract:

A 37-year-old female migrain patient is described, who suffered from episodes with pure lexical agraphia as the only symptom of migraine aura. The MRI showed multiple subcortical white matter lesions. Central inflammatory and demyelinating disorders were excluded. This case suggests that, during a migraine aura, even very circumscribed brain areas involved in complex neuropsychological processing can be affected.

APA, Harvard, Vancouver, ISO, and other styles

30

Raieli, Vincenzo, Mariarita Capizzi, Antonio Marino, Giovanni Di Nardo, Umberto Raucci, and Pasquale Parisi. "Study on “Atypical” Migraine Auras in the Pediatric Age: The Role of Cortical Spreading Depression and the Physiopathogenetic Hypothesis Arising from Our Clinical Cases." Life 12, no. 3 (March 18, 2022): 450. http://dx.doi.org/10.3390/life12030450.

Full text

Abstract:

Migraine is a complex neurologic disorder by which several systems of the central nervous system (autonomous system, affective, cognitive, sensory and motor system) may be affected on different levels. About a fourth of migraine patients have migraine auras. The most common aura is the visual aura followed by the sensorial aura but motor deficits, as well as deficits of higher cortical centers (disorders of thinking, orientation, coherence, or concentration), may occur as well. In analogy with a headache diary, an aura diary can deliver important help in the diagnostic process of rare migraine manifestations and prevent the under-diagnosis of unusual migraine manifestations. Complex migraine manifestations are a diagnosis of exclusion, and a broad diagnostic work-up is necessary in order to exclude dangerous neurologic pathologies. In addition, here, we discuss the atypical clinical presentation and possible physio-pathogenetic related aspects of these atypical migraine aura features in the developmental age. In addition, we wanted to stress and analyze the clinical aspects of our children/adolescents with atypical auras, which seem to be more difficult to frame with the mechanisms originally proposed to explain the physio-pathogenetic relationship between CSD and aura. Finally, we discuss in detail the complex aspects of this topic on the basis of available data and propose new terminology: “Multiple, Synchronous and Asynchronous, Cortical and Subcortical Spreading Depression”.

APA, Harvard, Vancouver, ISO, and other styles

31

João, Ana Alagoa, Tomas B. Goucha, and Isabel P. Martins. "Aura status: A not so frequent aura." Cephalalgia 34, no. 14 (April 16, 2014): 1150–62. http://dx.doi.org/10.1177/0333102414530525.

Full text

Abstract:

Background Migraine aura status is a variety of migraine aura with unvalidated research criteria. Aim and methods We conducted a systematic review of published cases and a retrospective analysis of 500 cases of migraine with aura to evaluate the applicability and clinical features of ICHD-III beta criteria, compared to a more liberal definition for its diagnosis: ≥3 aura episodes for up to three consecutive days. Results Many publications under this title correspond to persistent or formerly designated prolonged auras. Nine cases fulfilled ICHD-III beta status criteria. In our series, either 1.7% or 4.2% cases fulfilled ICDH-III beta or our definition, respectively. Regardless of the criteria, aura status patients were older at onset of status than those with typical aura, had a predominance of visual symptoms, normal neuroimaging and no sequelae. Status recurred in a few. Conclusion Both criteria identify a similar population in terms of age, gender, main symptoms, imaging and outcome. Since patients with closely recurring auras might raise the same approach independently of the criteria, the use of more liberal criteria will allow more cases for detailed diagnosis and therapeutic analysis, eventually leading to the identification of subtypes.

APA, Harvard, Vancouver, ISO, and other styles

32

Vetvik, Kjersti G., E. Anne MacGregor, Christofer Lundqvist, and Michael B. Russell. "Prevalence of menstrual migraine: A population-based study." Cephalalgia 34, no. 4 (October 7, 2013): 280–88. http://dx.doi.org/10.1177/0333102413507637.

Full text

Abstract:

Aim To present data from a population-based epidemiological study on menstrual migraine. Material and methods Altogether, 5000 women aged 30–34 years were screened for menstrual migraine. Women with self-reported menstrual migraine in at least half of their menstrual cycles were invited to an interview and examination. We expanded the International Classification of Headache Disorders III beta appendix criteria on menstrual migraine to include both migraine without aura and migraine with aura, as well as probable menstrual migraine with aura and migraine without aura. Results A total of 237 women were included in the study. The prevalence among all women was as follows: any type of menstrual migraine 7.6%; menstrual migraine without aura 6.1%; menstrual migraine with aura 0.6%; probable menstrual migraine without aura 0.6%; probable menstrual migraine with aura 0.3%. The corresponding figures among female migraineurs were: any type of menstrual migraine 22.0%, menstrual migraine without aura 17.6%, menstrual migraine with aura 1.7%, probable menstrual migraine without aura 1.6% and probable menstrual migraine with aura 1.0%. Conclusion More than one of every five female migraineurs aged 30–34 years have migraine in ≥50% of menstruations. The majority has menstrual migraine without aura and one of eight women had migraine with aura in relation to their menstruation. Our results indicate that the ICHD III beta appendix criteria of menstrual migraine are not exhaustive.

APA, Harvard, Vancouver, ISO, and other styles

33

Ranson, R., H. Igarashi, EA MacGregor, and M. Wilkinson. "The Similarities and Differences of Migraine with Aura and Migraine Without Aura: A Preliminary Study." Cephalalgia 11, no. 4 (September 1991): 189–92. http://dx.doi.org/10.1046/j.1468-2982.1991.1104189.x.

Full text

Abstract:

A preliminary study was undertaken to provide clinical evidence to support the hypothesis that: “Migraine with aura, migraine without aura and aura alone are the same condition, which differ in degree rather than pathophysiology.” At the City of London Migraine Clinic, 50 patients consecutively attending the clinic with a past or present history of migraine with aura were questioned. Of the 50 patients questioned 36 (70%) had a combination of migraine with aura, migraine without aura and/or aura alone; i.e. 70% had had more than one type of migraine attack. The duration, severity and frequency of attacks did not differ between migraine with and migraine without aura. Conclusion-the results support the hypothesis that migraine with and migraine without aura, and aura alone are not separate conditions, because: (1) most patients suffer from more than one type of migraine attack; (2) there are no significant differences in the characteristics of the migraine attacks in the different groups; (3) there are no significant differences in the characteristics of the subjects.

APA, Harvard, Vancouver, ISO, and other styles

34

Shill, Sajal Kumar, Md Abbas Uddin, Shah Didar Imam, and Ayesha Hasina. "Association between serum total cholesterol and migraine." Central Medical College Journal 5, no. 1 (June 12, 2022): 41–46. http://dx.doi.org/10.3329/cemecj.v5i1.60204.

Full text

Abstract:

Background: There is increasing evidence that migraine with aura is associated with increased risk of ischemic stroke and other vascular disease events. Furthermore migraine has been associated with increased prevalence of specific cardiovascular risk factors, such as hypercholesterolemia has been proposed. Aims and objectives: The present study is aimed at to evaluate the association between serum total cholesterol and migraine. Material and methods: This observational cross sectional study was carried out in Neurology Department in Mymensingh Medical College from December 2016 to November 2018 for a period of 2 years. Patients were selected by purposive sampling. Among 100 patients, 50 grouped as migraineur and 50 grouped as non-migraineur for the study. Results: Serum total cholesterol was significantly higher in migraine than non-migraine. Serum total cholesterol was significantly higher in late age of migraine group and migraine with aura. Conclusion: Elevated level of serum total cholesterol was associated with migraine than non-migraine. Serum total cholesterol was significantly higher in late age of migraine group and migraine with aura. Central Medical College Journal Vol 5 No 1 Jan 2021 PP 41-46

APA, Harvard, Vancouver, ISO, and other styles

35

Carvalho, Gabriela F., Flávia Heck Vianna-Bell, Lidiane L. Florencio, Carina F. Pinheiro, Fabiola Dach, Marcelo E. Bigal, and Debora Bevilaqua-Grossi. "Presence of vestibular symptoms and related disability in migraine with and without aura and chronic migraine." Cephalalgia 39, no. 1 (April 10, 2018): 29–37. http://dx.doi.org/10.1177/0333102418769948.

Full text

Abstract:

Objective To assess the presence and handicap due to vestibular symptoms in three subgroups of patients with migraine and controls. Methods Women between 18–55 years old were diagnosed by headache specialists and stratified as migraine with aura (n = 60), migraine without aura (n = 60), chronic migraine (n = 60) and controls (n = 60). Information regarding demographics, headache and vestibular symptoms were collected in this cross-sectional study. The self-perceived handicap related to vestibular symptoms was assessed through the Dizziness Handicap Inventory questionnaire. Results A total of 85% of women with migraine with aura and chronic migraine had vestibular symptoms contrasted to 70% of the migraine without aura group ( p < 0.05), and 12% of the control group reported symptoms ( p < 0.0001). Patients with migraine exhibited greater Dizziness Handicap Inventory scores than controls ( p < 0.001); and migraine with aura and chronic migraine groups reached greater scores than migraine without aura ( p < 0.01). Presence of migraine is associated with a greater risk of vestibular symptoms (migraine without aura: 5.20, migraine with aura: 6.60, chronic migraine:6.20, p < 0.0003) and with a greater risk of moderate-to-severe handicap (migraine without aura: 20.0, migraine with aura: 40.0, chronic migraine: 40.0, p < 0.0003). The presence of aura and greater migraine frequency adds to the risk of any handicap (migraine with aura: 1.9, chronic migraine: 1.7, p < 0.04) and to the risk of moderate-to-severe handicap (migraine with aura: 2.0, chronic migraine: 2.0, p < 0.0003). Migraine aura, intensity and frequency predict 36% of the dizziness handicap. Conclusion The prevalence of vestibular symptoms is increased in migraine during and between headache attacks, particularly in migraine with aura and chronic migraine along with an increased handicap due to those symptoms. Vestibular symptoms among subgroups of migraine should be considered when evaluating the functional impact of migraine.

APA, Harvard, Vancouver, ISO, and other styles

36

Turan, Hale, Bahriye Horasanli, Murat Ugur, and Hande Arslan. "Procalcitonin Levels in Migraine Patients." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 38, no. 1 (January 2011): 124–28. http://dx.doi.org/10.1017/s0317167100011161.

Full text

Abstract:

Abstract:Objectives:Migraine is a risk factor for ischemic stroke. Sterile vascular inflammation may develop during migraine attacks. This study aims to investigate procalcitonin (PCT) levels amongst migraine patients as they are important markers for infection and sepsis, but can also be found at elevated levels in various cases of inflammation.Methods:Eighty adult migraine patients participated in our study. Patients were initially separated into two main groups; Group-1 consisted of 34 patients who had migraines during the attack period. Group-2 consisted of 46 patients during the period in-between attacks. Afterwards, patients were further divided into four subgroups based on their aura status; Group-1a Migraine without aura, 27 patients during attack period, Group-1b Migraine with aura, 7 patients during attack period, Group-2a Migraine without aura, 40 patients during the period in-between attacks, Group-2b Migraine with aura, 6 patients during the period in-between attacks.Results:Average PCT levels in patients during attack periods were found to be higher than the average PCT levels of patients during the period in-between attacks. These elevated levels were determined to be statistically significant(p<0.01). Serum PCT levels of the patients with migraine without aura during the attack period were significantly higher than those of patients during the period in-between attacks(p<0.01).Conclusions:Based on significantly high levels of PCT, our results support the idea that sterile inflammation plays a role in migraine pathogenesis. Further studies are necessary to understand whether PCT is a marker for ischemic stroke risk in patients who go through frequent migraine attacks.

APA, Harvard, Vancouver, ISO, and other styles

37

Ball, HA, Z. Samaan, S. Brewster, N. Craddock, M. Gill, A. Korszun, W. Maier, et al. "Depression, Migraine With Aura and Migraine Without Aura: Their Familiality and Interrelatedness." Cephalalgia 29, no. 8 (August 2009): 848–54. http://dx.doi.org/10.1111/j.1468-2982.2008.01808.x.

Full text

Abstract:

Migraine is frequently comorbid with depression. There appear to be common aetiological factors for both disorders, but the aetiology of migraine within depressed patients, in particular the significance of aura, has been little studied. A large sample of concordantly depressed sibling pairs [the Depression-Network (DeNT) sample] was assessed as having migraine with aura (MA), migraine without aura (MoA), probable migraine or no migraine according to International Headache Society guidelines. Correlations between siblings' migraine status were used to assess the nature of familial liability to migraine. A multiple threshold isocorrelational model fit best, in which different syndromes are conceptualized as different severities of one underlying dimension rather than as having separate aetiologies. Thus, MA and MoA were found to be different forms of the same disorder, with MA occupying the more extreme end of the spectrum of liability. Implications for our understanding of the relationship between migraine and depression are discussed.

APA, Harvard, Vancouver, ISO, and other styles

38

Viana, Michele, Mattias Linde, Grazia Sances, Natascia Ghiotto, Elena Guaschino, Marta Allena, Salvatore Terrazzino, Giuseppe Nappi, Peter J. Goadsby, and Cristina Tassorelli. "Migraine aura symptoms: Duration, succession and temporal relationship to headache." Cephalalgia 36, no. 5 (July 8, 2015): 413–21. http://dx.doi.org/10.1177/0333102415593089.

Full text

Abstract:

Background As there are no biological markers, a detailed description of symptoms, particularly temporal characteristics, is crucial when diagnosing migraine aura. Hitherto these temporal aspects have not been studied in detail. Methods We conducted a prospective diary-aided study of the duration and the succession of aura symptoms and their temporal relationship with headache. Results Fifty-four patients completed the study recording in a diary the characteristics of three consecutive auras ( n = 162 auras). The median duration of visual, sensory and dysphasic symptoms were 30, 20 and 20 minutes, respectively. Visual symptoms lasted for more than one hour in 14% of auras ( n = 158), sensory symptoms in 21% of auras ( n = 52), and dysphasic symptoms in 17% of auras ( n = 18). Twenty-six percent of patients had at least one aura out of three with one symptom lasting for more than one hour. In aura with multiple symptoms the subsequent symptom, second versus first one or third versus second, might either start simultaneously (34 and 18%), during (37 and 55%), with the end (5 and 9%), or after (24 and 18%) the previous aura symptom. The headache phase started before the aura (9%), simultaneously with the onset of aura (14%), during the aura (26%), simultaneously with the end of aura (15%) or after the end of aura (36%). Conclusion We provide data to suggest that symptoms may last longer than one hour in a relevant proportion of auras or migraine with aura patients, and that there is a high variability of scenarios in terms of time relationship among aura symptoms and between aura and headache.

APA, Harvard, Vancouver, ISO, and other styles

39

Rasmussen, BK. "Migraine with Aura and Migraine Without Aura are two Different Entities." Cephalalgia 15, no. 3 (June 1995): 183–85. http://dx.doi.org/10.1046/j.1468-2982.1995.015003183.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Blau, JN. "Migraine with Aura and Migraine Without Aura are not Different Entities." Cephalalgia 15, no. 3 (June 1995): 186–90. http://dx.doi.org/10.1046/j.1468-2982.1995.015003186.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Raieli, V., D. Raimondo, R. Cammalleri, and R. Camarda. "Migraine Headaches in Adolescents: A Student Population-Based Study in Monreale." Cephalalgia 15, no. 1 (February 1995): 5–12. http://dx.doi.org/10.1046/j.1468-2982.1995.1501005.x.

Full text

Abstract:

We assessed the prevalence of migraine headaches in an epidemiological survey of an 11 to 14-year-old student population. Migraine headaches were classified on the basis of questionnaires and neurological examination using the operational diagnostic criteria of the International Headache Society. Prevalence of migraine without aura (IHS code 1.1) was 2.35%; that of migraine with aura (IHS code 1.2) was 0.62%. Migraine without aura was equally distributed among males and females, whereas migraine with aura was preponderant in the female cohort. The prevalence of migraine headaches in males was constant through the ages studied, whereas the prevalence of migraine headaches in females reached a peak at age 12 and plateaued over the following two years. Although the new IHS classification criteria of migraines are reliable and exhaustive, some subcriteria may not be valid in a juvenile population. For instance, the duration of the pain in young migraineurs is often briefer than in adults, and the intensity of pain was almost always described as moderate or severe. Therefore, in order to increase the reliability and comprehensiveness of the IHS classification, minor modifications should be made.

APA, Harvard, Vancouver, ISO, and other styles

42

Bigal, ME, CA Bordini, SJ Tepper, and JG Speciali. "Intravenous Magnesium Sulphate in the Acute Treatment of Migraine Without Aura and Migraine with Aura. A Randomized, Double-Blind, Placebo-Controlled Study." Cephalalgia 22, no. 5 (June 2002): 345–53. http://dx.doi.org/10.1046/j.1468-2982.2002.00364.x.

Full text

Abstract:

Magnesium sulphate has been used in the acute treatment of migraines; some studies found it to be a highly effective medication in the acute control of migraine pain and associated symptoms. This randomized, double-blind, placebo-controlled study assesses the effect of magnesium sulphate on the pain and associated symptoms in patients with migraine without aura and migraine with aura. Sixty patients in each group were assigned at random to receive magnesium sulphate, 1000 mg intravenously, or 0.9% physiological saline, 10 ml. We used seven parameters of analgesic evaluation and an analogue scale to assess nausea, photophobia and phonophobia. In the migraine without aura group there was no statistically significant difference in the patients who received magnesium sulphate vs. placebo in pain relief. The analgesic therapeutic gain was 17% and number needed to treat was 5.98 at 1 h. There was also no statistical difference in relief of nausea. We did observe a significant lower intensity of photophobia and phonophobia in patients who received magnesium sulphate. In the migraine with aura group patients receiving magnesium sulphate presented a statistically significant improvement of pain and of all associated symptoms compared with controls. The analgesic therapeutic gain was 36.7% at 1 h. A smaller number of patients continued to have aura in the magnesium sulphate group compared with placebo 1 h after the administration of medication. Our data support the idea that magnesium sulphate can be used for the treatment of all symptoms in migraine with aura, or as an adjuvant therapy for associated symptoms in patients with migraine without aura.

APA, Harvard, Vancouver, ISO, and other styles

43

Russell, MB. "Genetics of migraine without aura, migraine with aura, migrainous disorder, head trauma migraine without aura and tension-type headache." Cephalalgia 21, no. 7 (September 2001): 778–80. http://dx.doi.org/10.1046/j.1468-2982.2001.00249.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Russell, MB. "Genetics of Migraine without Aura, Migraine with Aura, Migrainous Disorder, Head Trauma Migraine without Aura and Tension-Type Headache." Cephalalgia 21, no. 7 (September 2001): 778–80. http://dx.doi.org/10.1177/033310240102100709.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Cuadrado, María L., Ángel Aledo-Serrano, Pedro López-Ruiz, Álvaro Gutiérrez-Viedma, Cristina Fernández, Aida Orviz, and José A. Arias. "Greater occipital nerve block for the acute treatment of prolonged or persistent migraine aura." Cephalalgia 37, no. 8 (June 10, 2016): 812–18. http://dx.doi.org/10.1177/0333102416655160.

Full text

Abstract:

Background Presently, there is no evidence to guide the acute treatment of migraine aura. We aimed to describe the effect of greater occipital nerve (GON) anaesthetic block as a symptomatic treatment for long-lasting (prolonged or persistent) migraine aura. Methods Patients who presented with migraine aura lasting > 2 hours were consecutively recruited during one year at the Headache Unit and the Emergency Department of a tertiary hospital. All patients underwent a bilateral GON block with bupivacaine 0.5%. Patients were followed up for 24 hours. Results A total of 22 auras were treated in 18 patients. Auras consisted of visual ( n = 13), visual and sensory ( n = 4) or sensory symptoms alone ( n = 5). Eleven episodes met diagnostic criteria for persistent aura (>1 week) without infarction. The response was complete without early recurrence in 11 cases (50%), complete with recurrence in < 24 hours in two cases (9.1%), and partial with ≥ 50% improvement in six cases (27.3%). Complete responses without recurrence were more common in cases with prolonged auras lasting < 1 week than in those with persistent auras (72.7% vs. 27.3%; p = 0.033). Conclusions GON block could be an effective symptomatic treatment for prolonged or persistent migraine aura. Randomised controlled trials are still required to confirm these results.

APA, Harvard, Vancouver, ISO, and other styles

46

Wolthausen, J., S. Sternberg, C. Gerloff, and A. May. "Are Cortical Spreading Depression and Headache in Migraine Causally Linked?" Cephalalgia 29, no. 2 (February 2009): 244–49. http://dx.doi.org/10.1111/j.1468-2982.2008.01713.x.

Full text

Abstract:

During the past few decades, much controversy has surrounded the pathophysiology of migraine. Cortical spreading depression (CSD) is widely accepted as the neuronal process underlying visual auras. It has been proposed that CSD can also cause the headaches, at least in migraine with aura. We describe three patients, each fulfilling the International Headache Society criteria for migraine with aura, who suffered from headaches 6–10 days per month. Two patients were treated with flunarizine and the third patient with topiramate for the duration of 4 months. All patients reported that aura symptoms resolved completely, whereas the migraine headache attacks persisted or even increased. These observations question the theory that CSD (silent or not) is a prerequisite for migraine headaches.

APA, Harvard, Vancouver, ISO, and other styles

47

de Ceuster, Laura, Ton van Diepen, and Peter J. Koehler. "Migraine with aura triggered by cardiac myxoma: Case report and literature review." Cephalalgia 30, no. 11 (July 20, 2010): 1396–99. http://dx.doi.org/10.1177/0333102410378928.

Full text

Abstract:

We present a new case of cardiac myxoma triggering migraine auras. A 52-year-old woman was suffering from migraine attacks with aura. Magnetic resonance imaging (MRI) showed no abnormalities. Subsequently, she had a minor stroke with multiple ischaemic lesions bilaterally on repeat MRI. An echocardiogram showed a myxoma of the left atrial wall. After removal of the myxoma she was free of symptoms. In the past, seven cardiac myxoma associated migraine patients have been reported. Other cardiac abnormalities, patent foramen ovale in particular, are known to be associated with migraine with aura. We attempted to compare the mechanisms by which cardiac myxoma and other cardiac abnormalities could trigger cortical spreading depression leading to migraine with aura.

APA, Harvard, Vancouver, ISO, and other styles

48

Christiansen, I., LL Thomsen, D. Daugaard, V. Ulrich, and J. Olesen. "Glyceryl Trinitrate Induces Attacks of Migraine Without Aura in Sufferers of Migraine with Aura." Cephalalgia 19, no. 7 (September 1999): 660–67. http://dx.doi.org/10.1046/j.1468-2982.1999.019007660.x.

Full text

Abstract:

Migraine with aura and migraine without aura have the same pain phase, thus indicating that migraine with aura and migraine without aura share a common pathway of nociception. In recent years, increasing evidence has suggested that the messenger molecule nitric oxide (NO) is involved in pain mechanisms of migraine without aura. In order to clarify whether the same is true for migraine with aura, in the present study we examined the headache response to intravenous infusion of glyceryl trinitrate (GTN) (0.5 μg/kg/min for 20 min) in 12 sufferers of migraine with aura. The specific aim was to elucidate whether an aura and/or an attack of migraine without aura could be induced. Fourteen healthy subjects served as controls. Aura symptoms were not elicited in any subject. Headache was more severe in migraineurs than in the controls during and immediately after GTN infusion ( p=0.037) as well as during the following 11 h ( p=0.008). In the controls, the GTN-induced headache gradually disappeared, whereas in migraineurs peak headache intensity occurred at a mean time of 240 min post-infusion. At this time the induced headache in 6 of 12 migraineurs fulfilled the diagnostic criteria for migraine without aura of the International Headache Society. The results therefore suggest that NO is involved in the pain mechanisms of migraine with aura. Since cortical spreading depression has been shown to liberate NO in animals, this finding may help our understanding of the coupling between cortical spreading depression and headache in migraine with aura.

APA, Harvard, Vancouver, ISO, and other styles

49

Kallela, M., M. Wessman, M. Färkkilä, A. Palotie, M. Koskenvuo, M.-L. Honkasalo, and J. Kaprio. "Clinical Characteristics of Migraine in A Population-Based Twin Sample: Similarities and Differences Between Migraine with and Without Aura." Cephalalgia 19, no. 3 (April 1999): 151–58. http://dx.doi.org/10.1046/j.1468-2982.1999.1903151.x.

Full text

Abstract:

Objective: To look into clinical differences between migraine with and without aura in a population-based sample of migraineurs. Background: Migraine presents in two major forms, migraine with and migraine without aura. With the exception of the aura phase, the clinical characteristics of these entities are very similar. Despite this, however, the recent epidemiological data underline differences between migraine with and without aura. We tried to examine whether other features besides the aura differ between these two major forms of migraine. Methods: We studied 321 twins suffering from migraine with aura and 166 twins with migraine without aura from the population-based Finnish Twin Cohort. Migraine was diagnosed according to the criteria of the International Headache Society (MS). Analysis was based on the combination of a mailed questionnaire and a telephone interview by a neurologist. Special attention was paid to differences between migraine with and without aura. Results: Some qualities of headaches differed between IHS defined migraine with and without aura. Unilateral headache (Chi-squared p=0.039) and photophobia (Chi-squared p=0.010) were more typical for migraine with aura, while nausea was more typical for migraine without aura (Chi-squared p=0.002). Duration of headache in migraine without aura was also longer man in migraine with aura (Mann-Whitney U-test 0.007). Conclusions: There are clinical differences between IHS defined migraine with and without aura; even the headache phase between the two entities differs. It is worthwhile distinguishing between them when looking for the elusive genes for these more common forms of migraine.

APA, Harvard, Vancouver, ISO, and other styles

50

Didriksen, Maria, Thomas F. Hansen, Lise W. Thørner, Kristoffer S. Burgdorf, Christian Erikstrup, Ole B. Pedersen, Helene M. Paarup, et al. "Restless legs syndrome is associated with increased risk of migraine." Cephalalgia Reports 1 (January 1, 2018): 251581631878074. http://dx.doi.org/10.1177/2515816318780743.

Full text

Abstract:

Migraine and restless legs syndrome (RLS) are common disorders that are associated with a high level of individual suffering and major comorbidities. The aetiologies of the disorders are largely unknown, although both migraine and RLS have been linked to disturbances in the dopaminergic system and sleep issues, suggesting a relationship between the disorders. This study examines the association between RLS and migraine in a large population of otherwise healthy adults who are not taking medication. Cross-sectional study that included 20,938 participants enrolled in the Danish Blood Donor Study from 1 May 2015 to 1 February 2017. The study included complete information on migraines, the Cambridge-Hopkins RLS questionnaire, the Major Depression Inventory Scale, sex, age, body mass index (BMI), educational level, smoking status and alcohol consumption. Associations between RLS and migraine, with and without aura, were examined using multivariable logistic regression analysis. Among the participants, 4827 were self-reported migraine sufferers and 1091 were classified as suffering from RLS. Individuals with RLS had an increased risk of migraine compared to non-RLS sufferers, with an odds ratio (OR) = 1.52 (95% confidence interval: 1.33–1.73). For the investigated subtypes of migraine, this association was found to be OR = 1.55 (1.31–1.83) for migraines with aura and OR = 1.29 (1.09–1.52) for migraines without aura. We found a significantly increased occurrence of migraine in individuals with RLS. This risk was independent of sex, age, BMI, educational level, smoking status, alcohol consumption and depressive disorder. Our findings suggest that RLS and migraine may have a common aetiology.

APA, Harvard, Vancouver, ISO, and other styles

Journal articles on the topic 'Migraine with aura'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles