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Academic literature on the topic 'Migraine – Aspect endocrinien'
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Dissertations / Theses on the topic "Migraine – Aspect endocrinien"
Barnet, Maxime. "Etude comparative chez les rats mâles et femelles de l'implication du complexe trigémino-cervical et du locus coeruleus dans l'intégration d'une douleur méningée." Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2021. http://www.theses.fr/2021UCFAC120.
Full textMigraine is a chronic condition characterised by the occurrence of intense headaches associated with other symptoms such as photo/phonophobia, nausea/vomiting or allodynia: pain triggered by non-painful stimulation. These symptoms appear in attacks interspersed with intervals of calm. Migraines affect 15 to 18% of the population worldwide, and are found preferentially in women, sometimes more intensely during menstruation. Although some of the mechanisms of migraine are beginning to be understood, there are still many questions to be answered, in particular how migraine pain is integrated and whether this integration differs according to the sex of the individual.In our project, we explored in male and female rats the involvement of the trigemino-cervical complex (TCC) and the Locus Coeruleus (LC) in the development of skin allodynia in a model of meningeal pain induced by repeated injection of inflammatory soup (IS). The first brain region, the TCC, is the first central relay from the orofacial region including the meninges. The LC is a noradrenergic nucleus whose descending pathways will, among other things, modulate pain and project to the TCC. By combining behavioural analyses and immunohistological techniques, we have shown in both males and females that a dural injection of IS induces allodynia, which becomes persistent with repeated IS injections. However, the evolution of allodynia is more rapid in females. By dissociating females according to their hormonal cycle: proestrus/estrus (P/E) and Metestrus/Diestrus (M/D), we showed that P/E females had a greater cephalic allodynia than M/D females after 2 injections of IS. Furthermore, using the neuronal activation marker c-Fos, P/E females showed greater activation in the TCC following meningeal inflammation. In contrast to TCC neurons, LC neurons were not activated by IS, however, we could observe, under physiological conditions, a significant sexual dimorphism of the LC: C-Fos neurons in the LC are in greater quantity in females than in males. Finally, we examined the projections of the LC using tracing techniques and confirmed the existence of direct projections of the LC to the TCC and indirect projections using the rostro-ventral medulla as an intermediate. We also observed the existence of superficial cortical projections, which could have an influence on the meningeal vasculature, and indirectly on the TCC. However, there are no anatomical differences in these projections between males and females.Taken together, these results demonstrate that the integration of meningeal pain is dependent on the hormonal cycle, and that TCC activity reflects this integration after two injections of SI. We have also shown the existence of direct and indirect pathways that may allow the LC to modulate the TCC. Finally, our project demonstrates the need to include both sexes in scientific studies and to take into account the hormonal cycle
Books on the topic "Migraine – Aspect endocrinien"
Diamond, Seymour. The hormone headache: New ways to prevent, manage, and treat migraines and other headaches. New York, N.Y., U.S.A: Macmillan, 1995.
Find full text1941-, Sheftell Fred D., ed. Headache relief for women: How you can manage and preventpain. Boston: Little, Brown and Co., 1995.
Find full textHeadache Relief. MJF Books, 2000.
Find full textRapoport, Alan M., and Fred D. Sheftell. Headache Relief for Women: How You Can Manage and Prevent Pain. Little Brown & Co (T), 1996.
Find full textRapoport, Alan M., and Fred D. Sheftell. Headache Relief for Women: How You Can Manage and Prevent Pain. Little, Brown and Company, 1996.
Find full textBook chapters on the topic "Migraine – Aspect endocrinien"
Carr, James A., and David O. Norris. "The Adrenal Glands." In Endocrine Disruption, 111–34. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780195137491.003.0005.
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