Dissertations / Theses on the topic 'Microsatellites'
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Jentzsch, Iris Miriam Vargas. "Comparative genomics of microsatellite abundance: a critical analysis of methods and definitions." Thesis, University of Canterbury. Biological Sciences, 2009. http://hdl.handle.net/10092/4282.
Full textRose, Owen Charles. "The evolution of microsatellites." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286155.
Full textKhayms, Vadim. "Advanced propulsion for microsatellites." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/8824.
Full textIncludes bibliographical references (leaves 162-166).
Microsatellites have become increasingly popular in recent years as they offer significant cost savings, higher reliability, and are generally more affordable for a large variety of commercial applications. Since many microsatellite missions require considerable propulsion capabilities, miniaturization of the propulsion subsystem is critical in the design of most miniature spacecraft. A broad range of existing propulsion technologies have been considered for the purpose of identifying those devices which maintain high performance at small scale. Scaling laws were developed for each of the selected devices so as to preserve, whenever possible, the basic non-dimensional quantities which ultimately determine the performance of the individual thrusters at small scale. Hall thrusters were initially identified as most promising. In an effort to miniaturize the Hall thruster, a number of complications have been encountered. Some of the most troublesome were higher magnetic field requirements, larger internal heat fluxes and temperatures, and difficulties associated with the manufacturing of the various miniaturized components. In order to validate the proposed scaling laws, a 50 Watt Hall thruster has been designed, manufactured, and tested in a vacuum tank. Results of the experimental testing indicate that, although the maximum thrust levels obtained were on the order of 1.8 mN, about two thirds of the nominal design value, the propellant utilization efficiencies were unexpectedly low at approximately 40%. Close examination of the magnetic assembly has shown that the tip of the iron center pole was overheating during operation due to the insufficient heat conduction. The tip temperatures were estimated to reach 900°C, exceeding the Curie point of iron. As a consequence of the change in the magnetic field profile and the resultant leakage of electrons, the observed ionization fraction and, therefore, the utilization efficiency were lower than expected. Despite the low efficiencies, which were most likely caused by the design imperfections rather than physical limitations, the effort to miniaturize a Hall thruster has provided a number of useful insights for any such attempts in the future. Most importantly, this work has highlighted the generic difficulty, common to all plasma thrusters, associated with the increase of the plasma density as the scale of the device is reduced. The consequences of strict scaling, most notably the higher particle fluxes which cause an increase in the erosion rates and significant loss of operating life at small scale, created a strong incentive to search for propulsion schemes which avoid ionization by electron bombardment. In the quest for a more durable device that could operate at low power, yet provide sufficient operating life to be of practical interest, colloidal thrusters were considered for miniaturization. These are representatives of a technology of electrostatic accelerators which does not rely on ionization in the gas phase and, hence, their operating life is not compromised at small scale. In addition to their intrinsically small dimensions and extremely low operating power levels, eliminating the need for further "miniaturization", colloidal thrusters possess a number of desirable characteristics which make them ideal for many microsatellite missions. Although the physics of electrospray emitters has been studied for decades, many of the mechanisms responsible for the formation of charged jets are still poorly understood. In order to gain further insight, a semi-analytical fluid model was developed to predict the effects of fluid's viscosity on the flow pattern. Results of the analysis indicate that over a broad range of operating conditions viscous shear flow is insignificant in the vicinity of the jet irrespective of the fluid's viscosity. In an attempt to further understand the physics of colloidal thrusters, specifically the effects of internal pressure, electrode geometry, and the internal electrostatic fields on the processes involved in the formation of charged jets, a detailed electrohydrodynamic model was formulated. A numerical scheme was developed to solve for the shape of the fluid meniscus given a prescribed set of operating conditions, fluid properties, and electrode configurations. Intermediate solutions for the conical region have already been obtained, however, convergence in the vicinity of the jet requires further studies. A fully developed model promises to provide valuable information and guidance in the design of colloidal thrusters.
by Vadim Khayms.
Ph.D.
Chilakamarri, Sunita R. "Genetic differentiation in Alewife populations using microsatellite loci." Link to electronic thesis, 2005. http://www.wpi.edu/Pubs/ETD/Available/etd-053105-164623/.
Full textBodnarik, Julia G., Dave Hamara, Michael Groza, Ashley C. Stowe, Arnold Burger, Keivan G. Stassun, Liviu Matei, Joanna C. Egner, Walter M. Harris, and Vladimir Buliga. "Neutron detector development for microsatellites." SPIE-INT SOC OPTICAL ENGINEERING, 2017. http://hdl.handle.net/10150/627176.
Full textSheikh, Sanea. "Microsatellites in the Flycatcher Genome." Thesis, Uppsala universitet, Systematisk biologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-191385.
Full textHarr, Bettina. "Evolution of microsatellites in Drosophila." [S.l. : s.n.], 2000. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8845129.
Full textMarouillat-Védrine, Sylviane. "Etudes des variations structurales chromosomiques dans l'autisme et la déficience mentale." Thesis, Tours, 2011. http://www.theses.fr/2011TOUR3133/document.
Full textAutism and mental retardation are two neurodevelopmental syndromes involving genetic factors. Our work consists in finding new candidate genes or susceptibility factors. 106 autistic patients and 68 sporadic non-syndromic mentally retardated patients were studied.We have shown an association between allele 4 of a microsatellite marker GXAlu locasized in 17q11.2, in intron 27b of the NF1 gene and patients with non-syndromic mental retardation.We contributed to the study on the NLGN4X gene. We demonstrated an increase of expression of NLGN4X transcript, in an autistic patient with non-syndromic mental retardation linked to a mutation in the NLGN4X gene promoter.We study the 22q13 region with MLPA method, we have demonstrated a deletion de novo of at least 1Mb in an autistic patient.The copy number variations (CNV) have been investigated in an autistic population by QPCR. We identified 27 variations on 17 genes among the 36 investigated. The CNV observed in ITGA6, TAGLN3, HOXA1, DLG4 and UBE2C genes are interesting because of the involvement of these genes in brain development or neuronal function.These results require further experiments for validation
Karhu, A. (Auli). "Evolution and applications of pine microsatellites." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514259246.
Full textTaylor, Tiawanna. "The development of microsatellites for parrots (Psittaciformes)." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288084.
Full textMcLinko, Ryan (Ryan M. ). "Conceptual Phase Structural Design Tool for Microsatellites." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/67068.
Full textThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student submitted PDF version of thesis.
Includes bibliographical references (p. 122-124).
Gaining traction or momentum in the conceptual design phase for a complex system can be an arduous and daunting process, whether the complex system being designed is a satellite, airplane, car, or one of countless other systems. The design of small satellites is particularly affected by the difficulties in gaining traction since most of the customized tools that exist are proprietary, a significant experience base is required to be able to perform system level design trades, and the issue that most satellites serve one-of-a-kind applications. Of the subsystems in a satellite, the structures subsystem (along with other "downstream" subsystems, such as power and thermal), tends to be less mature during the conceptual design phase since its design depends strongly on the particular designs and requirements of each of the other subsystems, which also take time to mature. The Conceptual Phase Structural Design Tool for Microsatellites (SDT) facilitates the development of potential small satellite structural architectures and the selection of an initial satellite architecture to use in the detailed design process. The tool is capable of evaluating the strength, stiffness, mass, and inertial properties of a satellite architecture and is customizable to a wide range of potential missions by allowing for a number of structural architectures and customizable component placement. Furthermore, the tool has been developed with two key niches in mind. First, it is available to students with little to no satellite design experience, thus enabling a greater number of people, including those who are unfamiliar with the process of structural design at the beginning of the program, to design higher quality spacecraft from the start. Second, it is open source and deployable in a state that is usable and customizable by members of the satellite design industry.
by Ryan McLinko.
S.M.
Csilléry, Katalin. "Statistical inference in population genetics using microsatellites." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3865.
Full textLoire, Etienne. "Evolution des microsatellites codants chez les primates." Paris 6, 2009. http://www.theses.fr/2009PA066495.
Full textBuschiazzo, Emmanuel. "Conservation and Evolution of Microsatellites in Vertebrate Genomes." Thesis, University of Canterbury. Biological Sciences, 2008. http://hdl.handle.net/10092/1595.
Full textVowles, Edward Joseph. "The evolution of microsatellites and their flanking sequences." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439035.
Full textKhayms, Vadim. "Design of a miniaturized Hall thruster for microsatellites." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/50313.
Full textRoss-Adams, Helen Esther. "The characterisation of selected grapevine cultivars using microsatellites." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/53092.
Full textENGLISH ABSTRACT: Grapevine supports one of the oldest industries in South Africa today, and is also of significant international importance. With increasing international trade and the transport of fruit and other grapevine-derived products between borders, it has become increasingly important for South African farmers and viticulturalists to ensure their products conform to strict international market requirements if they are to remain competitive. Such requirements include the correct and accurate identification of berries and wines according to cultivar. In light of this, 26 different wine, table grape and rootstock cultivars, as well as a number of clones from KWV's core germplasm collection were characterised at 16 microsatellite marker loci. Microsatellite markers are known for their high level of informativeness, reliability and reproducibility, and are widely used in the identification and characterisation of plant varieties, population analyses and forensic applications. Unique allelic profiles were obtained for all but two plants, which proved to be identical at all loci considered, and thus 'clones'. These profiles were collated to form a database, containing the DNA fingerprints of each sample at each locus. The relative levels of informativeness of each marker used were also determined, and compared with those found in the literature. Six markers proved to be highly informative, and are promising in the potential application of this technology to other cultivars. The applicability of microsatellite markers to such studies is confirmed; this approach could easily be extended to include any number of cultivars of national and international interest. The results of such an investigation would have important implications for both the farming and commercial industries alike.
AFRIKAANSE OPSOMMING: Wingerd ondersteun een van die oudste industriee in Suid-Afrika vandag, en is ook van groat intemasionale belang. Met die toenemende intemasionale ruilhandel en die vervoer van vrugte en ander wingerd produkte tussen grense, het dit toenemend belangrik geword vir SuidAfrikaanse wingerdboere om te. verseker dat hulle produkte voldoen aan die streng vereistes van die intemasional mark, indien hulle kompeterend wil bly. Hierdie vereistes sluit in die korrekte en akkurate identifisering van druiwe en wyn volgens kultivar. Met hierdie vereistes in ag geneem, is 26 verskillende wyn, tafeldruif en wortelstok kultivars, asook 'n aantal klone van die KWV se kern kiemplasma versameling, gekarakteriseer by 16 mikrosatelliet merker loki. Mikrosatelliet merkers word gekenmerk deur 'n hoe vlak van informatiwiteit, betroubaarheid en herhaalbaarheid en word wydverspreid gebruik in die identifisering en karakterisering van plant varieteite, populasie analises en forensiese toepassings. Unieke alleliese profiele is vir a1 die plante verkry, behalwe vir twee plante wat identiese resultate by alle loki opgelewer het en dus as "klone" beskou kan word. Hierdie profiele is bymekaar gevoeg om 'n databasis te vorm wat die DNA vingerafdrukke van elke monster by elke lokus bevat. Die relatiewe vlak van informatiwiteit van al die merkers is ook bepaal en vergelyk met merkers in die literatuur. Ses van die merkers blyk om hoogs informatief te wees en lyk belowend in die potensiele toepassing van hierdie tegnologie op ander kultivars. Die toepaslikheid van mikrosatelliet merkers op sulke studies is bevestig; hierdie benadering kan maklik aangepas word om enige aantal kultivars van nasionale en intemasionale belang in te sluit. Die resultate van s6 'n ondersoek sal belangrike implikasies inhou vir beide die boerdery en kommersiele industriee.
Leclercq, Sébastien. "Origines des séquences microsatellites dans les génomes eucaryotes." Phd thesis, Montpellier 2, 2007. http://www.theses.fr/2007MON20190.
Full textMicrosatellites, are genomic elements found in the genomes of all living species. This thesis focuses on the microsatellite apparition, by analysing the complete human genome sequence. This requires extracting microsatellite loci from the sequence, using specific algorithms. However these available algorithms differs in detection method. The first part of this thesis is dedicated to the comparison of some algorithms of tandem repeats detection, and present an overview of their qualities and limitations. Microsatellite birth essentially derived from transposable elements (TEs) or from mutation from any DNA sequence. The analysis of TE-mediated birth focuses on the role of Alu elements. Mutation mediated birth is analysed though three different mechanisms: point mutation, DNA slippage and adjacent micro-duplication of a small number of nucleotides. A general model of microsatellite apparition is then proposed, suggesting a more complex apparition dynamic than was previously thought
Leclercq, Sébastien. "Origines des séquences microsatellites dans les génomes eucaryotes." Phd thesis, Université Montpellier II - Sciences et Techniques du Languedoc, 2007. http://tel.archives-ouvertes.fr/tel-00261560.
Full textPour traiter ces questions, nous nous sommes basés sur l'analyse de la séquence du génome humain. L'une des lacunes de ce type d'analyse est qu'il faut d'abord extraire les microsatellites du génome, et qu'il existe plusieurs algorithmes de nature et fonctionnement différents. La première partie de cette thèse se concentre donc sur la comparaison de quelques-uns des principaux algorithmes de recherche de répétitions en tandem, et dresse un portait des différentes qualités et limitations de chacun des algorithmes.
Deux possibilités majeures sont détaillées, l'apparition par l'intermédiaire d'éléments transposables (ETs), et l'apparition spontanée à partir d'une séquence quelconque. Dans le premier cas, l'étude est focalisée sur le rôle des queues polyA des séquences Alu chez les primates. La question de l'apparition à partir d'une séquence quelconque cherche à établir l'impact de trois mécanismes mutationnels différents sur la création et le développement primordial des microsatellites : la mutation ponctuelle, le glissement de polymérase et la micro-duplication adjacente de quelques nucléotides. Un modèle général d'apparition des microsatellites est aussi proposé, suggérant une dynamique d'apparition plus complexe que ce qui était précédemment supposé.
Bodur, Cagri. "Genetic Structure Analysis Of Honeybee Populations Based On Microsatellites." Phd thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12606592/index.pdf.
Full textrkiye and one population from Cyprus using 9 microsatellite loci. Average gene diversity levels were found to change between 0,542 and 0,681. Heterozygosity levels, mean number of alleles per population, presence of diagnostic alleles and pairwise FST values confirmed the mitochondrial DNA finding that Anatolian honeybees belong to north Mediterranean (C) lineage. We detected a very high level of genetic divergence among populations of Tü
rkiye and Cyprus based on pairwise FST levels (between 0,0 and 0,2). Out of 66 population pairs 52 were found to be genetically different significantly. This level of significant differentiation has not been reported yet in any other study conducted on European and African honeybee populations. High allelic ranges, and high divergence indicate that Anatolia is a genetic centre for C lineage honeybees. We suggest that certain precautions should be taken to limit or forbid introduction and trade of Italian and Carniolan honeybees to Tü
rkiye and Cyprus in order to preserve genetic resources formed in these territories in thousands of years. Effectivity at previously isolated regions in Artvin, Ardahan and Kirklareli was confirmed by the high genetic differentiation in honeybees of these regions. Genetically differentiated Karaburun and Cyprus honeybees v and geographical positions of the regions make these zones first candidates as new isolation areas.
Paetkau, David Henry. "Genetic studies of North American bear populations using microsatellites." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq23052.pdf.
Full textDuncan, Stuart. "Development and exploitation of GPS attitude determination for microsatellites." Thesis, University of Surrey, 2010. http://epubs.surrey.ac.uk/804951/.
Full textFernandez-Salivar, Juan A. "Miniaturised UV imaging spectrometer for atmospheric monitoring from microsatellites." Thesis, University of Surrey, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502648.
Full textBodo, Sahra. "Induction d'un processus d'instabilité des microsatellites du génome dans des modèles murin et cellulaire : intérêt physiopathologique et clinique." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066565/document.
Full textInactivation of the MMR (mismatch repair) system promotes the oncogenic process of microsatellite instability (MSI). During my PhD, I firstly investigated the role of azathioprine (Aza) in the induction of MSI tumors in mice. Epidemiological studies reported a correlation between the occurrence of late MSI cancers in humans and long-term treatment with this immunosuppressant whose cytotoxicity was shown in vitro to be mediated by MMR activity. Using a dose-response study, I observed the occurrence of rare late-onset MSI lymphomas in wild-type mice treated with Aza, but not with ciclosporin (another immunosuppressant used for comparison). These results established in vivo that long-term Aza exposure is a risk factor for the emergence of MSI tumors. Secondly, I was interested in the CMMRD syndrome (constitutional MMR deficiency), a major and rare predisposition to MSI cancers. Since CMMRD patients are carriers of biallelic germline mutations of a MMR gene, diagnosis is based on constitutional genotyping, a method that was found non-contributory when a variant of unknown significance is detected (30% patients). In this context, I developed a complementary approach for the detection of this syndrome in at-risk patients, based on the hypothesis that two functional features of MMR-deficient tumor cells, i.e. the MSI phenotype and the tolerance to genotoxic agents such as Aza, can be demonstrated in non-neoplastic tissues of CMMRD patients. We provided a sensitive and specific method that may constitute a valuable tool when diagnosis of CMMRD could not be confirmed by genetic testing
Fouquet, Marc. "Earth imaging with microsatellites : an investigation, design, implementation and in-orbit demonstration of electronic imaging systems for Earth observation on-board low-cost microsatellites." Thesis, University of Surrey, 1995. http://epubs.surrey.ac.uk/844455/.
Full textBond, Joanna Margaret. "Genetic analysis of the sperm whale (Physeter macrocephalus) using microsatellites." Thesis, University of Cambridge, 1999. https://www.repository.cam.ac.uk/handle/1810/265611.
Full textValsecchi, Elena. "Genetic analysis of the humpback whale (Megaptera novaeangliae) using microsatellites." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242544.
Full textFretwell, Neale. "A search for human Y-chromosome-specific minisatellites and microsatellites." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/34411.
Full textDelaugerre, Constance. "Diagnostic moléculaire de l'hémophilie A : évaluation de l'informativité des microsatellites." Paris 5, 1997. http://www.theses.fr/1997PA05P221.
Full textWallace, Aaron L. "The taxonomic and systematic relationships of several salt marsh Fucus taxa (heterokontophyta, phaeophyceae) within the Gulf of Maine and Ireland examined using microsatellite markers." View this thesis online, 2005. http://libraries.maine.edu/gateway/oroauth.asp?file=orono/etheses/37803141.pdf.
Full textTitle from PDF title page. Available through UMI ProQuest Digital Dissertations. Includes bibliographical references. Also issued in print.
Ramakrishna, W. "DNA fingerprinting and molecular characterization of microsatellites and minisatellites in rice." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1994. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2817.
Full textPrudhomme, Jorian. "Phlébotomes et écosystèmes : impact des facteurs biotiques et abiotiques sur la structure génétique et phénotypique des populations." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS027/document.
Full textSandflies are hematophagous insects belonging to the family Psychodidae and the subfamily phlebotominae. This diptera, yellowish, relatively small (2-3 mm) has about 800 species. 70 of these species have been identified as potential vectors of which forty are proven ones. They can transmit different pathogens; the main ones are Leishmania and phlebovirus.This thesis focused on sandflies, vectors of leishmaniasis. Leishmaniases are parasitic diseases caused by protozoa of the genus Leishmania. They affect a wide range of vertebrate hosts, including humans and dogs. They are still a major problem of public health in many countries and are currently in expansion. Although this disease is widely studied, we still have a lot to learn about its vector: the sandfly. For example, the organization of populations in ecosystems and the parameters which structure them are very little studied up to now. It is therefore essential to know the biology of the different actors of a parasite cycle to better understand the transmission of pathogens, to assess risks of transmission, and finally to be able to effectively fight against the disease.In this context, the aim of this thesis is to study the ecology and the structuring of sandfly populations in a known endemic area of leishmaniasis and the impact of biotic and abiotic factors on their organization. To reach this objective, we performed captures of sandflies along a 14km transect located in the Montpellier region which presents an altitudinal, climate and environmental diversity. Sandfly populations have been characterized by taxonomic, spatio-temporal, genetic (microsatellites) and morphometric (geometry morphometry) approaches. The genetic, morphometric and species distribution results were then confronted with climatic (temperature, relative humidity) or environmental parameters (altitude, slope, station, microhabitat).During this work, four species were captured: Phlebotomus ariasi (93.23%), P. perniciosus (0.48%), P. mascittii (0.11%) and S. minuta (6.18%). They have a seasonal activity from May to October with an abundance peak in July-August when average temperatures are optimal for sandflies (20-30°C). Although the environment has been considerably transformed in our study area in 30 years, the abundance of sandflies does not seem to have changed significantly, highlighting their ability to adapt to ecosystem modifications in short and long-term. The presence and abundance of the two predominant species (P. ariasi and S. minuta) are significantly influenced by altitude, temperature, relative humidity, slope and wall orientation.The genetic analyses show that diversity is maintained at all scales of study and that sandflies are organized in micropopulations. The morphometric geometry data reveal a sexual dimorphism, well known in insects but also a phenotypic structuring correlated to environmental or temporal factors (month, slope, altitude and station).Both of these approaches, because of their complementarity, help provide information on the ecology and organization of sandfly populations and to discuss about the consequences in terms of leishmaniasis transmission
Santani, Avni Bhawan. "Genomic analysis of the horse Y chromosome." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1494.
Full textGunn, Melissa Rose School of Biological Earth & Environmental Science UNSW. "The use of microsatellites as a surrogate for quantitative trait variation in conservation." Awarded by:University of New South Wales. School of Biological, Earth and Environmental Science, 2003. http://handle.unsw.edu.au/1959.4/22457.
Full textLai, Yau-lin Caroline. "Genotyping of gestational trophoblastic disease." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23427383.
Full textDuffy, Andrew J. "Genetic variability and population differentiation in Scandinavian wolverines." Connect to this title online, 1997. http://www.nlc-bnc.ca/obj/s4/f2/dsk2/ftp01/MQ36353.pdf.
Full textLong, Qiaoming. "Molecular cloning of chicken transforming growth factor β1 and isolation of microsatellites." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/29227.
Full textLORIDON, KARINE. "Analyse de la variabilite genetique de sequences microsatellites trinucleotidiques chez arabidopsis thaliana." Clermont-Ferrand 2, 1998. http://www.theses.fr/1998CLF22066.
Full textPomares, Christelle. "Epidémiologie et formes cliniques atypiques de la leishmaniose à Leishmania infantum. : Apport du génotypage parasitaire." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5055/document.
Full textLeishmaniasis due to Leishmania infantum is a zoonotic disease transmitted from mammal to mammal through the bite of an insect vector the sandfly female. Beside the classical triad of visceral leishmaniasis symptoms: fever, pallor and splenomegaly, many clinical forms could be associated with this parasite infection. Asymptomatic carriage of L. infantum is the most common and the most widespread in the Old World and New World. Many other clinical forms are present and some subjects will develop only isolated lymphadenopathy. These forms are intermediate between pauci symptomatic and visceral leishmaniasis forms. Whereas L. infantum is not typically associated with mucosal forms, several cases have been described. Indeed, in the 3 academic hospitals of Marseille, Montpellier and Nice from 1997 to 2009, 10 cases were revealed mainly in immunocompromised patients. To understand the role of parasite in clinical expression, nine strains isolated from asymptomatic carriers were genotyped using microsatellite. The nine strains have few polymorphisms and seven of them are identical with a unique genotype. In addition, those strains are very different from strains of HIV-positive subjects. If the strains genetic appears to have a role in the clinical expression of the disease, the environment in which individuals live in endemic areas is associated with an excess of risk to develop visceral leishmaniasis. While in Marseille, cases of visceral leishmaniasis occur in an urban environment, they take place in Nice in a rural environment, as it is classically described. To investigate differences between parasite strains form Nice and Marseille studies with microsatellites are ongoing
Beveridge, Maxine. "Molecular ecology of Dawson's burrowing bee Amegilla dawsoni (Hymenoptera: Anthophorini)." University of Western Australia. School of Animal Biology, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0091.
Full textMallory, Melanie Ann. "Development and Characterization of Microsatellite Markers for the Grain Amaranths (Amaranthus spp. L.)." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1988.pdf.
Full textChoudhury, Arpita. "The use of microsatellite DNA fingerprinting for aquaculture and fisheries science /." View online ; access limited to URI, 2005. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3186898.
Full textChirhart, Scott Edward. "Evolutionary implications of microsatellite variation in the Peromyscus maniculatus species group." Texas A&M University, 2003. http://hdl.handle.net/1969.1/1279.
Full textMartins, Aline Fernandes Angêlla [UNESP]. "Estrutura populacional de Anopheles darlingi em diferentes localidades de Rondônia ao longo do Rio Madeira através da genotipagem de microssatélites." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/102683.
Full textConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
A malária é uma das principais parasitoses humanas do mundo, causando mais de um milhão de mortes, e quase 500 milhões de casos agudos da doença por ano. No Brasil, esta doença continua sendo uma das mais importantes do país, tendo sido registrados no ano de 2009 mais de 300 mil casos. O mosquito Anopheles darlingi é o principal vetor desta doença no Brasil e outros países da América do Sul. Devido à sua importância como vetor da malária humana, estudos sobre a estrutura populacional de An. darlingi tem sido objeto de vários estudos. A sua distribuição na Região Amazônica é ampla e dados recentes mostram alto grau de heterogeneidade, tanto genética como de comportamento. Grande parte desta variabilidade observada em An. darlingi pode estar relacionada com estratégias adaptativas para explorar nichos ecológicos distintos enquanto que a estrutura populacional e a diferenciação pode ser explicada por diferenças no tamanho efetivo da população, padrões de fluxo gênico e acontecimentos históricos e de colonização recente. De igual modo, alterações ambientais efetuadas pelo homem podem ter um impacto significativo na dinâmica de populações de vetores e, consequentemente, na transmissão da malária. Este projeto utilizou a genotipagem de 10 microssatélites para o estudo populacional de Anopheles darlingi coletados em sete localidades ao longo da extensão das Hidrelétricas de Jirau e Santo Antônio, às margens do Rio Madeira, em Porto Velho – RO. Estes métodos foram aplicados na caracterização de amostras coletadas nestas regiões no 1º e 2° semestres de 2007. O objetivo do trabalho foi analisar a estrutura populacional de An. darlingi ao longo do Rio Madeira, na área de influência das Hidrelétricas de Jirau e Santo Antônio. Os resultados mostraram alto fluxo gênico entre as populações, mesmo distando de 70 km. Foram encontradas diferenças...
Malaria is the major human parasitic diseases in the world, causing more than a million deaths and almost 500 million acute cases of disease per year. In Brazil, this disease remains one of the most important, having been recorded in the year of 2009 more than 300.000 cases. The mosquito Anopheles darlingi is the principal malaria vector in Brazil and other countries in South America. Due to its importance as a vector of human malaria, population structure of Anopheles darlingi has been the subject of several studies. Its distribution in the Amazon region is large and recent data show a high degree of heterogeneity, regarding genetic and behavioral aspects. Much of this observed variability may be related to adaptive strategies to exploit different ecological niches, while the population structure and differentiation can be explained by differences in effective population size, patterns of gene flow and historical events and recent colonization. Similarly, environmental changes made by man can take a significant impact on population dynamics of vectors and hence the transmission of malaria. This project genotyping 10 microsatellites for population-based study of Anopheles darlingi collected at seven locations along Rio Madeira at Porto Velho - RO. These methods were applied in the characterization of samples collected in these regions in the 1st and 2nd semesters of 2007. The objective was to analyze the population structure of Anopheles darlingi along the Madeira River, the area of influence of Hydroelectric of Jirau and San Antonio. The results showed high gene flow among populations, even at 70 km apart. We found significant genetic differences among populations when samples were compared seasonally. The samples collected in the first half of the year showed effective population size 10x greater than those collected in the second half. These differences may represent differences... (Complete abstract click electronic access below)
Boley, Ryan Michael. "Relative species abundance and microhabitat preferences of larval Scaphirhynchus sturgeon in the middle Mississippi River." OpenSIUC, 2010. https://opensiuc.lib.siu.edu/theses/195.
Full textSchwartz, Tonia S. "Population structure of the gopher tortise (sic) (Gopherus polyphemus) in Florida, using microsatellites." [Tampa, Fla.] : University of South Florida, 2003. http://purl.fcla.edu/fcla/etd/SFE0000607.
Full textBatley, Jacqueline. "A study of the population ecology of willow beetles (Phyllodecta spp.) using microsatellites." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343295.
Full textJohnson, Kirsten M. "Characterization of length-dependent GGAA-microsatellites in EWS/FLI mediated Ewing sarcoma oncogenesis." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523384027382108.
Full textCroteau, Emily Katherine. "Population genetics and phylogeography of bobcats (Lynx rufus) using microsatellites and mitochondrial DNA." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1791777601&sid=3&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Full text"Department of Zoology." Keywords: Bobcats, Microsatellite, Mitochondrial DNA, Phylogeography, Population genetics, Lynx rufus. Includes bibliographical references (p. 98-111). Also available online.
Brockhurst, Veronica. "Development of novel DNA-based methods for the measurement of length polymorphisms (microsatellites)." Thesis, Queensland University of Technology, 2001.
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