Relevant bibliographies by topics / MicroRNA

Academic literature on the topic 'MicroRNA'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 July 2024

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Journal articles on the topic "MicroRNA"

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Varga, Zoltán V., Ágnes Zvara, Nóra Faragó, Gabriella F. Kocsis, Márton Pipicz, Renáta Gáspár, Péter Bencsik, et al. "MicroRNAs associated with ischemia-reperfusion injury and cardioprotection by ischemic pre- and postconditioning: protectomiRs." American Journal of Physiology-Heart and Circulatory Physiology 307, no. 2 (July 15, 2014): H216—H227. http://dx.doi.org/10.1152/ajpheart.00812.2013.

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We aimed to characterize early changes in microRNA expression in acute cardioprotection by ischemic pre- and postconditioning in rat hearts. Hearts isolated from male Wistar rats were subjected to 1) time-matched nonischemic perfusion, 2) ischemia-reperfusion (30 min of coronary occlusion and 120 min of reperfusion), 3) preconditioning (3 × 5 min of coronary occlusion) followed by ischemia-reperfusion, or 4) ischemia-reperfusion with postconditioning (6 × 10 s of global ischemia-reperfusion at the onset of reperfusion). Infarct size was significantly reduced by both interventions. Of 350 different microRNAs assessed by microarray analysis, 147–160 microRNAs showed detectable expression levels. Compared with microRNA alterations induced by ischemia-reperfusion versus time-matched nonischemic controls, five microRNAs were significantly affected by both pre- and postconditioning (microRNA-125b*, microRNA-139-3p, microRNA-320, microRNA-532-3p, and microRNA-188), four microRNAs were significantly affected by preconditioning (microRNA-487b, microRNA-139-5p, microRNA-192, and microRNA-212), and nine microRNAs were significantly affected by postconditioning (microRNA-1, microRNA let-7i, microRNA let-7e, microRNA let-7b, microRNA-181a, microRNA-208, microRNA-328, microRNA-335, and microRNA-503). Expression of randomly selected microRNAs was validated by quantitative real-time PCR. By a systematic comparison of the direction of microRNA expression changes in all groups, we identified microRNAs, specific mimics, or antagomiRs that may have pre- and postconditioning-like cardioprotective effects (protectomiRs). Transfection of selected protectomiRs (mimics of microRNA-139-5p, microRNA-125b*, microRNA let-7b, and inhibitor of microRNA-487b) into cardiac myocytes subjected to simulated ischemia-reperfusion showed a significant cytoprotective effect. This is the first demonstration that the ischemia-reperfusion-induced microRNA expression profile is significantly influenced by both pre- and postconditioning, which shows the involvement of microRNAs in cardioprotective signaling. Moreover, by analysis of microRNA expression patterns in cardioprotection by pre- and postconditioning, specific protectomiRs can be revealed as potential therapeutic tools for the treatment of ischemia-reperfusion injury.
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Liu, Zhong, Yong-Hua Tuo, Jian-Wen Chen, Qing-Yuan Wang, Songlin Li, Ming-Chang Li, Gang Dai, et al. "NADPH oxidase inhibitor regulates microRNAs with improved outcome after mechanical reperfusion." Journal of NeuroInterventional Surgery 9, no. 7 (June 20, 2016): 702–6. http://dx.doi.org/10.1136/neurintsurg-2016-012463.

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BackgroundInhibition of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) pathway improves the neurological outcome in the transient middle cerebral artery occlusion (tMCAO) animal model. In this study we analyzed the microRNAs profile targeting NOX2 and NOX4 genes and its response to NOX2/4 inhibitor VAS2870 to understand the mechanisms of this protective effect.MethodsThe intraluminal filament tMCAO model was established in hyperglycemic rats (n=106) with 5 hours ischemia followed by 19 hours reperfusion. NOX inhibitor VAS2870 was delivered intravenously before reperfusion. Infarct volume, hemorrhagic transformation, and mortality were determined at 24 hours after cerebral ischemia. MicroRNAs profile targeting NOX2 and NOX4 genes were predicted by microRNA databases and further evaluated by microRNA microarray and quantitative RT-PCR.ResultsTen microRNAs potentially targeting NOX2 and NOX4 genes (including microRNA-29a, microRNA-29c, microRNA-126a, microRNA-132, microRNA-136, microRNA-138, microRNA-139, microRNA-153, microRNA-337, and microRNA-376a) were significantly downregulated in the ischemic hemisphere in the tMCAO group compared with the sham-operated group, as shown by microRNA microarray and quantitative RT-PCR (all p<0.05). Intravenous treatment with NOX inhibitor VAS2870 before reperfusion increased the expression of microRNA-29a, microRNA-29c, microRNA-126a, and microRNA-132 compared with the tMCAO group (all p<0.05).ConclusionsSeveral microRNAs potentially targeting NOX2 and NOX4 genes displayed altered levels in hyperglycemic rats with the tMCAO model, suggesting their regulatory roles and targeting potentials for acute ischemic stroke treatment. Targeting specific microRNAs may represent a novel intervention opportunity to improve outcome and reduce hemorrhagic transformation after mechanical reperfusion for acute ischemic stroke.
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Zinovyeva, Anna Y., Isana Veksler-Lublinsky, Ajay A. Vashisht, James A. Wohlschlegel, and Victor R. Ambros. "Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal." Proceedings of the National Academy of Sciences 112, no. 38 (September 8, 2015): E5271—E5280. http://dx.doi.org/10.1073/pnas.1506576112.

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MicroRNAs are regulators of gene expression whose functions are critical for normal development and physiology. We have previously characterized mutations in a Caenorhabditis elegans microRNA-specific Argonaute ALG-1 (Argonaute-like gene) that are antimorphic [alg-1(anti)]. alg-1(anti) mutants have dramatically stronger microRNA-related phenotypes than animals with a complete loss of ALG-1. ALG-1(anti) miRISC (microRNA induced silencing complex) fails to undergo a functional transition from microRNA processing to target repression. To better understand this transition, we characterized the small RNA and protein populations associated with ALG-1(anti) complexes in vivo. We extensively characterized proteins associated with wild-type and mutant ALG-1 and found that the mutant ALG-1(anti) protein fails to interact with numerous miRISC cofactors, including proteins known to be necessary for target repression. In addition, alg-1(anti) mutants dramatically overaccumulated microRNA* (passenger) strands, and immunoprecipitated ALG-1(anti) complexes contained nonstoichiometric yields of mature microRNA and microRNA* strands, with some microRNA* strands present in the ALG-1(anti) Argonaute far in excess of the corresponding mature microRNAs. We show complex and microRNA-specific defects in microRNA strand selection and microRNA* strand disposal. For certain microRNAs (for example mir-58), microRNA guide strand selection by ALG-1(anti) appeared normal, but microRNA* strand release was inefficient. For other microRNAs (such as mir-2), both the microRNA and microRNA* strands were selected as guide by ALG-1(anti), indicating a defect in normal specificity of the strand choice. Our results suggest that wild-type ALG-1 complexes recognize structural features of particular microRNAs in the context of conducting the strand selection and microRNA* ejection steps of miRISC maturation.
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Jongen-Lavrencic, Mojca, Su Ming Sun, Menno K. Dijkstra, Peter J. M. Valk, and Bob Löwenberg. "MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia." Blood 111, no. 10 (May 15, 2008): 5078–85. http://dx.doi.org/10.1182/blood-2008-01-133355.

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Abstract Acute myeloid leukemia (AML) is a highly diverse disease characterized by various cytogenetic and molecular abnormalities. MicroRNAs are small noncoding RNAs that show variable expression during myeloid differentiation. MicroRNA expression in marrow blasts in 215 cases of newly diagnosed and (cyto)genetically defined AML was assessed using quantitative reverse-transcription–polymerase chain reaction (RT-PCR) for 260 human microRNAs. In the same series, mRNA gene expression profiles were established, allowing a direct comparison between microRNA and mRNA expression. We show that microRNA expression profiling following unsupervised analysis reveals distinctive microRNA signatures that correlate with cytogenetic and molecular subtypes of AML (ie, AMLs with t(8;21), t(15;17), inv(16), NPM1, and CEBPA mutations). Significantly differentially expressed microRNAs for genetic subtypes of AML were identified. Specific microRNAs with established oncogenic and tumor suppressor functions, such as microRNA-155, microRNA-21, and let-7, appear to be associated with particular subtypes. Combinations of selected sets of microRNAs could predict cytogenetically normal AML with mutations in the genes of NPM1 and CEBPA and FLT3-ITD with similar accuracy as mRNA probe set combinations defined by gene expression profiling. MicroRNA expression apparently bears specific relationships to the heterogeneous pathobiology of AML. Distinctive microRNA signatures appear of potential value in the clinical diagnosis of AML.
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Marcucci, Guido, Krzysztof Mrózek, Michael D. Radmacher, Ramiro Garzon, and Clara D. Bloomfield. "The prognostic and functional role of microRNAs in acute myeloid leukemia." Blood 117, no. 4 (January 27, 2011): 1121–29. http://dx.doi.org/10.1182/blood-2010-09-191312.

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Abstract Expression of microRNAs, a new class of noncoding RNAs that hybridize to target messenger RNA and regulate their translation into proteins, has been recently demonstrated to be altered in acute myeloid leukemia (AML). Distinctive patterns of increased expression and/or silencing of multiple microRNAs (microRNA signatures) have been associated with specific cytogenetic and molecular subsets of AML. Changes in the expression of several microRNAs altered in AML have been shown to have functional relevance in leukemogenesis, with some microRNAs acting as oncogenes and others as tumor suppressors. Both microRNA signatures and a single microRNA (ie, miR-181a) have been shown to supply prognostic information complementing that gained from cytogenetics, gene mutations, and altered gene expression. Moreover, it has been demonstrated experimentally that antileukemic effects can be achieved by modulating microRNA expression by pharmacologic agents and/or increasing low endogenous levels of microRNAs with tumor suppressor function by synthetic microRNA oligonucleotides, or down-regulating high endogenous levels of leukemogenic microRNAs by antisense oligonucleotides (antagomirs). Therefore, it is reasonable to predict the development of novel microRNA-based therapeutic approaches in AML. We review herein results of current studies analyzing changes of microRNA expression in AML and discuss their potential biologic, diagnostic, and prognostic relevance.
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Kiseleva, Y. Y., K. G. Ptitsyn, S. P. Radko, V. G. Zgoda, and A. I. Archakov. "Digital droplet PCR - a prospective technological approach to quantitative profiling of microRNA." Biomeditsinskaya Khimiya 62, no. 4 (2016): 403–10. http://dx.doi.org/10.18097/pbmc20166204403.

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MicroRNA is a special type of regulatory molecules governing gene expression. Circulating microRNAs found in blood and other biological fluids are considered today as potential biomarkers of human pathology. Presently, quantitative alterations of particular microRNAs are revealed for a large number of oncological diseases and other disorders. The recently emerged method of digital droplet PCR (ddPCR) possesses a number of advantages making this method the most suitable for verification and validation of perspective microRNA markers of human pathologies. Among these advantages are the high accuracy and reproducibility of microRNA quantification as well as the capability to directly measure the absolute number of microRNA copies with the large dynamic range and a high throughput. The paper reviews microRNA biogenesis, the origin of circulating microRNAs, and methods used for their quantification. The special technical features of ddPCR, which make it an attractive method both for studying microRNAs as biomarkers of human pathologies and for basic research devoted to aspects of gene regulation by microRNA molecules, are also discussed.
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Li, Li-Jie, Wei-Min Chang, and Michael Hsiao. "Aberrant Expression of microRNA Clusters in Head and Neck Cancer Development and Progression: Current and Future Translational Impacts." Pharmaceuticals 14, no. 3 (February 27, 2021): 194. http://dx.doi.org/10.3390/ph14030194.

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MicroRNAs are small non-coding RNAs known to negative regulate endogenous genes. Some microRNAs have high sequence conservation and localize as clusters in the genome. Their coordination is regulated by simple genetic and epigenetic events mechanism. In cells, single microRNAs can regulate multiple genes and microRNA clusters contain multiple microRNAs. MicroRNAs can be differentially expressed and act as oncogenic or tumor suppressor microRNAs, which are based on the roles of microRNA-regulated genes. It is vital to understand their effects, regulation, and various biological functions under both normal and disease conditions. Head and neck squamous cell carcinomas are some of the leading causes of cancer-related deaths worldwide and are regulated by many factors, including the dysregulation of microRNAs and their clusters. In disease stages, microRNA clusters can potentially control every field of oncogenic function, including growth, proliferation, apoptosis, migration, and intercellular commutation. Furthermore, microRNA clusters are regulated by genetic mutations or translocations, transcription factors, and epigenetic modifications. Additionally, microRNA clusters harbor the potential to act therapeutically against cancer in the future. Here, we review recent advances in microRNA cluster research, especially relative to head and neck cancers, and discuss their regulation and biological functions under pathological conditions as well as translational applications.
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Qin, Li-Xuan. "An Integrative Analysis of microRNA and mRNA Expression–-A Case Study." Cancer Informatics 6 (January 2008): CIN.S633. http://dx.doi.org/10.4137/cin.s633.

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Background MicroRNAs are believed to play an important role in gene expression regulation. They have been shown to be involved in cell cycle regulation and cancer. MicroRNA expression profiling became available owing to recent technology advancement. In some studies, both microRNA expression and mRNA expression are measured, which allows an integrated analysis of microRNA and mRNA expression. Results We demonstrated three aspects of an integrated analysis of microRNA and mRNA expression, through a case study of human cancer data. We showed that (1) microRNA expression efficiently sorts tumors from normal tissues regardless of tumor type, while gene expression does not; (2) many microRNAs are down-regulated in tumors and these microRNAs can be clustered in two ways: microRNAs similarly affected by cancer and microRNAs similarly interacting with genes; (3) taking let-7f as an example, targets genes can be identified and they can be clustered based on their relationship with let-7f expression. Discussion Our findings in this paper were made using novel applications of existing statistical methods: hierarchical clustering was applied with a new distance measure–the co-clustering frequency–to identify sample clusters that are stable; microRNA-gene correlation profiles were subject to hierarchical clustering to identify microRNAs that similarly interact with genes and hence are likely functionally related; the clustering of regression models method was applied to identify microRNAs similarly related to cancer while adjusting for tissue type and genes similarly related to microRNA while adjusting for disease status. These analytic methods are applicable to interrogate multiple types of -omics data in general.
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Karkhane, Maryam, Hamed Esmaeil Lashgarian, Maryam Hormozi, Shirzad Fallahi, Kourosh Cheraghipour, and Abdolrazagh Marzban. "Oncogenesis and Tumor Inhibition by MicroRNAs and its Potential Therapeutic Applications: A Systematic Review." MicroRNA 9, no. 3 (April 13, 2020): 198–215. http://dx.doi.org/10.2174/2211536608666191104103834.

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MicroRNAs appear as small molecule modifiers, which improve many new findings and mechanical illustrations for critically important biological phenomena and pathologic events. The best-characterized non‐coding RNA family consists of about 2600 human microRNAs. Rich evidence has revealed their crucial importance in maintaining normal development, differentiation, growth control, aging, modulation of cell survival or apoptosis, as well as migration and metastasis as microRNAs dysregulation leads to cancer incidence and progression. By far, microRNAs have recently emerged as attractive targets for therapeutic intervention. The rationale for developing microRNA therapeutics is based on the premise that aberrantly expressed microRNAs play a significant role in the emergence of a variety of human diseases ranging from cardiovascular defects to cancer, and that repairing these microRNA deficiencies by either antagonizing or restoring microRNA function may yield a therapeutic benefit. Although microRNA antagonists are conceptually similar to other inhibitory therapies, improving the performance of microRNAs by microRNA replacement or inhibition that is a less well- described attitude. In this assay, we have condensed the last global knowledge and concepts regarding the involvement of microRNAs in cancer emergence, which has been achieved from the previous studies, consisting of the regulation of key cancer‐related pathways, such as cell cycle control and the DNA damage response and the disruption of profile expression in human cancer. Here, we have reviewed the special characteristics of microRNA replacement and inhibition therapies and discussed explorations linked with the delivery of microRNA mimics in turmeric cells. Besides, the achievement of biomarkers based on microRNAs in clinics is considered as novel non-invasive biomarkers in diagnostic and prognostic assessments.
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Zhang, Xiaomin, Gohar Azhar, Emmanuel D. Williams, Steven C. Rogers, and Jeanne Y. Wei. "MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes." BioMed Research International 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/732397.

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The microRNAs and microRNA clusters have been implicated in normal cardiac development and also disease, including cardiac hypertrophy, cardiomyopathy, heart failure, and arrhythmias. Since a microRNA cluster has from two to dozens of microRNAs, the expression of a microRNA cluster could have a substantial impact on its target genes. In the present study, the configuration and distribution of microRNA clusters in the mouse genome were examined at various inter-microRNA distances. Three important microRNA clusters that are significantly impacted during adult cardiac aging, the miR-17-92, miR-106a-363, and miR-106b-25, were also examined in terms of their genomic location, RNA transcript character, sequence homology, and their relationship with the corresponding microRNA families. Multiple microRNAs derived from the three clusters potentially target various protein components of the cdc42-SRF signaling pathway, which regulates cytoskeleton dynamics associated with cardiac structure and function. The data indicate that aging impacted the expression of both guide and passenger strands of the microRNA clusters; nutrient stress also affected the expression of the three microRNA clusters. The miR-17-92, miR-106a-363, and miR-106b-25 clusters are likely to impact the Cdc42-SRF signaling pathway and thereby affect cardiac morphology and function during pathological conditions and the aging process.
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Dissertations / Theses on the topic "MicroRNA"

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Khoshnaw, Sarkawt Majeed Omar. "Significance of microRNAs and microRNA maturation regulators in breast cancer." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.594865.

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Background: MicroRNAs (miRNAs) modulate gene expression by targeting mRNAs for cleavage or translational suppression. miRNAs have deregulated expression in human breast cancer (BC), and there is evidence suggesting that they function primarily as tumour suppressors. Dicer and Drosha are two proteins which play key roles in miRNA biogenesis to produce mature miRNAs from their precursor molecules, and are known to be deranged in human Be. The contribution of miRNAs and their maturation regulators in the initiation and progression of human Be can be exploited to achieve novel modifications in the existing diagnostic and therapeutic approaches in Be management. Methods: Protein expression levels of miRNA maturation regu lators, Dicer and Drosha, were assessed immunohistochemically in 2 sets of Be: 1) full-face sections of selected Be cases (n = 24) with normal breast parenchymal tissue (NBPT) and lesions representing different stages of Be progression (Ductal carcinoma in situ, DCIS; invasive breast cancer, IBC; and metastatic breast cancer, MBC) to assess their differential expression, 2) tissue microa rrays (TMAs) comprising a large and well-characterised series of primary IBC (n = 1902) to evaluate their biological, clinicopathological, prognostic and predictive significance. Additionally, miRNA expression profiling was explored in the 4 tissue components (NBPT, DCIS, IBC and MBC) of 7 BC cases using an Agilent microa rray-based miRNA profiling study, to investigate the differential expression of miRNAs in NBPT and different stages of BC progression. Results: Dicer and Drosha protein expression was observed to decrease with BC progression, which implies that loss of these two miRNA maturation regulators might have a role in the process of Be progression. In the IBC series, loss of Dicer expression was associated with features of aggressive behaviour including higher histological grade and loss of ER, PR and BRCA1 protein expression . Moreover, Dicer expression was revealed to be an independent predictor of a shorter disease free interval at 5 years, and predictive of better response to chemotherapy and to endocrine therapy. Loss of Drosha cytoplasmic expression was associated with higher tumour stage and loss of expression of BRCA1 and basal phenotype; and loss of Drosha nuclear expression was associated with larger tumour size, higher tumour grade, and loss of ER, PR, BRCA1, E-cadherin and CK14. Loss of Drosha cytoplasmic expression was associated with shorter Be specific survival, BC recurrence, and distant metastases, and th is correlation was maintained in ER-negative and HER2- negative cases. Loss of Drosha cytoplasmic expression was predictive of better response to systemic therapy in ER-negative patients. Furthermore, we present data revealing that some miRNAs are differentially expressed across the 4 tissue components (NBPT, DCIS, IBC and MBC). The comprehensive survey of miRNA expression profiling, confirmed differential expression of one miRNA previously reported to be deranged in BC, and identified 6 miRNAs downregulated du ring BC progression, 5 downregulated and 1 upregulated, which have not previously been linked to Be. Among the novel downregulated miRNA candidates, 2 (hsa-miR-1181 and hsa-miR-4322) were revealed to gradually reduce in amount across the 4 tissue components. These observatinos support the hypothesis that miRNAs play a role in tumourigenesis and in advancing BC tissues towards acquiring metastatic potential. Conclusions: The intimate involvement of miRNAs and their maturation regulators in malignant transformation, cellular invasion and metastases in BC makes them potentially relevant as future diagnostic, predictive and therapeutic targets. Although the current study is preliminary, we believe the results add to the present knowledge of Significance of miRNAs and their regulators in Be. Therefore, the results would serve as a robust initial set of potential biomarkers for validation in a larger cohort of patients.
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Arseni, Varvara. "MicroRNAs and the canonical microRNA biogenesis pathway in the planarian Schmidtea mediterranea." Thesis, University of Nottingham, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581999.

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miRNAs are an important class of small non-protein coding RNAs whose specific functions in animals are rapidly being elucidated. miRNAs regulate the expression of many animal genes by post-transcriptional gene silencing and play vital roles in stem cell maintenance, differentiation and apoptosis. In this study, planarians were used as a model system in order to study whether miRNAs have a regulatory role in their stem cell dynamics. Planarians are well known for their remarkable regenerative ability and their amazing capacity for constant re-patterning owing to a population of somatic pluripotent stem cells known as neoblasts. In particular, the aim of the study was to investigate the regulatory role miRNAs may have in planarian stem cell self renewal, proliferation and differentiation. Recently, the differential spatial patterns of expression of miRNAs in whole and regenerating planarians have been characterized by in situ hybridization to nascent miRNA transcripts. These miRNA expression patterns were the first to be determined for a Lophotrocozoan animal. The expression patterns of 42 miRNAs in adult planarians have been characterized, constituting a complete range of tissue specific expression patterns. The majority of planarian miRNAs were expressed either in areas where stem cells (neoblasts) are located and/or in the nervous system. Some miRNAs were definitively expressed in stem cells and dividing cells and moreover miRNAs were found to be expressed in germ stem cells of the sexual strain. Taken the facts that cellular proliferation and differentiation must be controlled during planarian regeneration and tissue homeostasis as well as that miRNAs have been implicated in the control stem cell functions in other organisms, aim of this study was to disrupt the canonical miRNA biosynthesis pathway. In that way, information about the global impact of miRNA regulation in planarian regeneration and tissue homeostasis would be gained.
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Sætrom, Ola. "Predicting MicroRNA targets." Thesis, Norwegian University of Science and Technology, Department of Computer and Information Science, 2005. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-9266.

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MicroRNAs are a large family of short non-encoding RNAs that regulated protein production by binding to mRNAs. A single miRNA can regulate an mRNA by itself, or several miRNAs can cooperate in regulating the mRNAs. This is all dependent on the degree of complementarity between the miRNA and the target mRNA. Here, we present the program TargetBoost that, using a classifier generated by a combination of hardware accelerated genetic programming and boosting, allows for screening several large dataset against several miRNAs, and computes a likelihood of that genes in the dataset is regulated by the set of miRNAs used in the screening. We also present results from comparison of several different scoring functions for measuring cooperative effects. We found that the classifier used in TargetBoost is best for finding target sites that regulate mRNAs by themselves. A demo of TargetBoost can be found on http://www.interagon.com/demo.

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BERTOLAZZI, Giorgio. "MicroRNA Interaction Networks." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/498927.

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La tesi di Giorgio Bertolazzi è incentrata sullo sviluppo di nuovi algoritmi per la predizione dei legami miRNA-mRNA. In particolare, un algoritmo di machine-learning viene proposto per l'upgrade del web tool ComiR; la versione originale di ComiR considerava soltanto i siti di legame dei miRNA collocati nella regione 3'UTR dell'RNA messaggero. La nuova versione di ComiR include nella ricerca dei legami la regione codificante dell'RNA messaggero.
Bertolazzi’s thesis focuses on developing and applying computational methods to predict microRNA binding sites located on messenger RNA molecules. MicroRNAs (miRNAs) regulate gene expression by binding target messenger RNA molecules (mRNAs). Therefore, the prediction of miRNA binding is important to investigate cellular processes. Moreover, alterations in miRNA activity have been associated with many human diseases, such as cancer. The thesis explores miRNA binding behavior and highlights fundamental information for miRNA target prediction. In particular, a machine learning approach is used to upgrade an existing target prediction algorithm named ComiR; the original version of ComiR considers miRNA binding sites located on mRNA 3’UTR region. The novel algorithm significantly improves the ComiR prediction capacity by including miRNA binding sites located on mRNA coding regions.
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Ammari, Meryem. "Rôle de miR-146a dans la régulation des fonctions monocytaires dans l’arthrite." Thesis, Montpellier 1, 2014. http://www.theses.fr/2014MON1T020.

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Les monocytes sont des leucocytes dérivés de précurseurs de la moelle osseuse pouvant se différencier en macrophages, cellules dendritiques (CD), ou ostéoclastes (OC). Ils jouent un rôle critique dans la persistance de l'inflammation et la destruction des articulations par le biais de mécanismes encore mal connus. Les monocytes sont composés de deux grandes sous-populations chez la souris, discriminées sur la base du marqueur de surface Ly6C. Il a été suggéré que les OC pouvait être préférentiellement différenciés à partir de la sous-population monocytaire Ly6Chigh, dont l'activation excessive et prolongée est une signature clé de nombreuses pathologies inflammatoires. Parmi les acteurs moléculaires responsables de la régulation de l'expression des gènes, les miARNs jouent un rôle majeur dans de nombreux processus physiologiques, dont la réponse inflammatoire, en régulant finement les programmes génétiques au niveau post-transcriptionnel. Leur implication dans l'ostéoclastogénèse est encore mal connue. Par ailleurs, leur expression est perturbée dans de nombreuses pathologies, dont la polyarthrite rhumatoïde qui implique à la fois un dysfonctionnement de la réponse inflammatoire et de l'homéostasie osseuse. Mon projet de thèse vise à mieux comprendre l'implication des sous-populations monocytaires dans la persistance de l'inflammation et de l'activité des OC au travers de l'étude du rôle de miR-146a dans des conditions physiologiques et inflammatoires. J'ai montré que miR-146a est le miARN le plus différemment exprimé entre monocytes classiques Ly6Chigh et non-classiques Ly6Clow, et que son expression est diminuée dans les Ly6Chigh en conditions arthritiques. J'ai également montré que la perte de miR-146a augmente l'ostéoclastogénèse in vitro et l'érosion osseuse in vivo chez les souris arthritiques. Enfin, la surexpression artificielle de miR-146a dans les monocytes Ly6Chigh inhibe la différenciation osteoclastique et la perte osseuse dans l'arthrite expérimentale chez la souris. Mes résultats suggèrent que miR-146a contrôle l'hétérogénéité fonctionnelle des monocytes et qu'une diminution de son expression dans la sous-population Ly6Chigh serait responsable de l'augmentation de l'osteoclastogénèse et de l'érosion osseuse observées en conditions arthritiques. Pour finir, mes résultats montrent également qu'augmenter l'expression de miR-146a dans les monocytes Ly6Chigh présente un intérêt thérapeutique pour contrecarrer la perte osseuse associée à l'arthrite
Introduction : Monocytes represent a prototypic cell type when investigating the interplay between immune and skeletal systems as they can give rise to different cell types including dendritic cells, macrophages and osteoclasts (OC), which play key roles in immunity and bone homeostasis. Circulating monocytes consist of at least two main functional subsets, Ly6Chigh and Ly6Clow monocytes. It has been suggested that OC might develop preferentially from the Ly6Chigh monocyte subset, which excessive and prolonged activation is a hallmark of many inflammatory diseases. Among key molecular rheostats of cell fate, micro(mi)RNAs are a class of regulatory RNAs that control basic biological functions and orchestrate inflammatory responses. Few miRNAs have been involved in osteoclastogenesis. The present study aimed at investigating the role of miRNAs in osteoclastogenesis in the context of monocyte subsets, under steady state and inflammatory conditions. Methods & Results : Using genome-wide miRNA expression study we have identified miRNAs and putative targeted pathways that are differentially expressed between Ly6Chigh and LyC6low FACS sorted mouse monocytes, and common to their human counter parts CD14+CD16- and CD14dimCD16+ monocytes, respectively. Among these, miR-146a showed higher expression in Ly6Clow monocytes when compared to Ly6Chigh monocytes. Under inflammatory arthritis conditions, expression of miR-146a in Ly6Chigh monocytes was down regulated as compared to healthy controls. Using mouse deficient for miR-146a, we showed that knockdown of miR-146a increased OC differentiation in vitro. While no bone phenotype was evidenced in miR-146a deficient mice, nor under steady state or ovariectomized conditions, arthritis-induced bone resorption and bone loss were increased in miR-146a knockout mice. Finally, using a liposomal formulation able to delivermiR-146a mimics to Ly6Chigh monocytes upon intravenous injection, we showed that enforced expression of miR-146a led to decreased number of TRAP positive cells within the synovium of arthritic mice, and efficiently reduced bone erosion in inflammatory arthritis. This effect was associated with decreased RelB expression in miR-146a-overexpressing Ly6Chigh osteoclast progenitors. Conclusion : Overall, our results show that specific over-expression of miR-146a in Ly6Chigh monocytes altered OC differentiation and decreased bone erosion in inflammatory arthritis. These data suggest a novel role for miR-146a in controlling osteoclast fate of Ly6Chigh monocyte progenitors and that reduced miR-146a expression in Ly6Chigh monocytes under arthritic conditions contributes to pathogenic bone loss. Finally, delivery of miR-146a mimics to Ly6Chigh monocytes may offer valuable therapeutic potential to interfere with pathological bone loss
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Dogini, Danyella Barbosa. "Quantificação de diferentes microRNAs no sistema nervoso central = implicações nos mecanismos de desenvolvimento e processos fisiopatologicos." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309739.

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Orientador: Iscia Lopes-Cendes
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: MicroRNAs são moléculas recém-descobertas de RNA não-codificadores que possuem de 21 a 24 nucleotídeos e que regulam a expressão após a transcrição dos genes alvo. Essa regulação pode ser realizada através da inibição da tradução ou da degradação do RNA mensageiro. Os miRNAs estão envolvidos em vários processo biológicos como, diferenciação celular e desenvolvimento embrionário, além de apresentarem expressão tecido e tempo-específica. Eles podem regular a expressão de pelo menos 1/3 de todos os genes humanos e estão envolvidos com a regulação do metabolismo e da apoptose. Os miRNAs são a chave como reguladores pós-transcricionais da neurogênese; estudos mostram que eles possuem a expressão associada com a transição entre proliferação e diferenciação e também tem expressão constitutiva em neurônios maduros, evidenciando o envolvimento dessas moléculas com o desenvolvimento do sistema nervoso central (SNC). Outros miRNAs estão sendo estudados e verifica-se que eles agem como reguladores de genes envolvidos em doenças como Alzheimer, Parkinson e, provavelmente, também devam possuir um papel na regulação das epilepsias. No primeiro trabalho, apresentado no segundo capítulo, investigamos o papel dos miRNAs no desenvolvimento do SNC através da quantificação de 104 miRNAs em cérebros em desenvolvimento de camundongos. No segundo trabalho, apresentado no terceiro capítulo, para analisarmos o papel dos miRNAs na epilepsia de lobo temporal, verificamos se havia presença de miRNAs com expressão diferenciada entre tecidos removidos de pacientes que se submeteram a cirurgia de hipocampectomia e tecidos normais provenientes de autópsias. Para ambos os experimentos, foram extraídos os RNAs dos tecidos e quantificados por PCR em tempo real com o kit MicroRNA Assay baseado em iniciadores com estrutura em stem loop. Nos camundongos, análises de bioinformática encontraram quatro cluster de acordo com a expressão dos miRNAs. Um cluster (C1) com 12 miRNAs (miR-9; miR-17- 5p; miR-124a; miR-125a; miR-125b;miR-130a; miR-140; miR-181a; miR-199a; miR-205; miR-214; miR-301) apresentou expressão com diferença significativa durante o desenvolvimento. Nos tecidos dos pacientes, após a análise de bioinformática, encontramos três miRNAs com expressão diferenciada entre pacientes e controle (miR-29b, miR-30d e let-7). Em ambos os experimentos analisamos os possíveis genes alvo desse miRNAs. Nos camundongos, nossos resultados sugerem a presença de um padrão específico de expressão no cluster C1, indicando que esses miRNAs possam ter um papel na regulação de genes envolvidos na neurogênese. Nos tecidos humanos, os genes alvo encontrados estão envolvidos, principalmente, em proliferação celular, neurogênese e apoptose, indicando uma provável atuação dos miRNAs na regulação de genes que estão envolvidos na epilepsia de lobo temporal
Abstract: MicroRNAs are a new class of small RNA molecules (21-24 nucleotide-long) that negatively regulate gene expression either by translational repression or target mRNA degradation. It is believed that about 30% of all human genes are targeted by these molecules. MiRNAs are involved in many important biological processes including cell differentiation, embryonic development and central nervous system formation, besides they showed specific temporal-space expression. They can regulate 1/3 of human genes and are involved in metabolism and apoptosis. miRNAs are the key as neurogenesis postranscriptional regulation; studies previous indicates miRNA expression associate with proliferation and differentiation in development of central nervous system (CNS) and housekeeping expression in mature neurons. They are involved in several diseases as Alzkeimer's and Parkinson and may have a role in epilepsy regulation. In second chapter, we analyze the miRNA expression in mouse brain during four stages of CNS development; in third chapter, we analyze hippocampal tissue of four patients who underwent selective resection of the mesial temporal structures for the treatment of clinically refractory seizures. In addition we used control samples from autopsy (n=4) for comparison. In both experiments, total RNA was isolated from tissues and used in real-time PCR reactions with TaqMan¿ microRNA assays (Applied Biosystems) to quantify 104 (mouse brain) or 157 (human tissue) different miRNAs. In mouse brain analysis, we were able to identified four different clusters (C1, C2, C3 and C4) of miRNAs expression. Significant differences in expression during development were observed only in miRNAs included in C1. Our results suggest the presence of a specific expression pattern in C1, indicating that these miRNAs could have an important role in gene regulation during neurogenesis. We found a significant decrease (p<0,05) in expression of 12 miRNAs (miR-9; miR-17-5p; miR-124a; miR-125a; miR-125b;miR-130a; miR-140; miR-181a; miR-199a; miR-205; miR-214; miR- 301) belonging to cluster C1 in latter stages of development. Computational target identification showed that 10 of the 12 miRNAs present in C1 could be involved in neurogenesis. In human tissues, bioinformatics analyzes identified three miRNAs species which were differently expressed in patients as compared to controls: let7a was over expressed in patients (4 fold increased), miR-29b and miR-30d were down-regulated in patients (2.5 fold and 0.5 fold decreased, respectively). Possible target genes for let-7a are NME6 and NCAM1 (which would be down-regulated in patients); for miR-29b is MCL-1 and for miR30d are CTNND2, LGI1 and SON (which would be up-regulated in patients). We have identified three different miRNA species differently expressed in hippocampal sclerosis. Gene functions related to the possible miRNA targets are involved mainly with cell proliferation, neurogenesis, cell adhesion and apoptosis. Our results indicate new molecular targets which should be explored in additional studies addressing miRNA regulation in hippocampal sclerosis
Doutorado
Neurociencias
Doutor em Fisiopatologia Medica
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Wang, Qi. "Using Imputed Microrna Regulation Based on Weighted Ranked Expression and Putative Microrna Targets and Analysis of Variance to Select Micrornas for Predicting Prostate Cancer Recurrence." Thesis, North Dakota State University, 2014. https://hdl.handle.net/10365/27341.

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Imputed microRNA regulation based on weighted ranked expression and putative microRNA targets (IMRE) is a method to predict microRNA regulation from genome-wide gene expression. A false discovery rate (FDR) for each microRNA is calculated using the expression of the microRNA putative targets to analyze the regulation between different conditions. FDR is calculated to identify the differences of gene expression. The dataset used in this research is the microarray gene expression of 596 patients with prostate cancer. This dataset includes three different phenotypes: PSA (Prostate-Specific Antigen recurrence), Systemic (Systemic Disease Progression) and NED (No Evidence of Disease). We used the IMRE and ANOVA methods to analyze the dataset and identified several microRNA candidates that can be used to predict PSA recurrence and systemic disease progression in prostate cancer patients.
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Kwan, Chun-kit Peter, and 關駿傑. "The expression of microRNA-34c and microRNA processing enzymes in preimplantation embryos." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44659283.

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D'Ario, G. "IDENTIFICATION OF INTRONIC MICRORNAS ALTERED IN BREAST CANCER THROUGH MICROARRAY HOST GENE EXPRESSION ANALYSIS." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/157939.

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MicroRNA (miRNAs) are endogenous non-coding RNAs of ∼ 22 nucleotides in length that function as post-transcriptional regulators of gene and pro- tein expression through degradation or translation inhibition of the target messenger RNAs. MiRNAs show altered expression profiles in several hu- man pathologies, including cancer. They can act as tumour suppressors or as oncogenes, depending on the characteristics of their target genes. More than half of the mammalian miRNAs, including several of the miR- NAs implicated in breast cancer, are localized within the introns of protein- coding genes, often organized in clusters, and usually transcribed together with their host gene. It is therefore possible, at least in principle, to iden- tify novel intronic cancer-regulated miRNAs by examining the expression profile of their host genes by means of microarrays. For this purpose, we analyzed the regulation of 253 miRNA host genes in five large breast cancer microarray data sets comprising more than 950 samples, examining their association with different clinical and pathological parameters such as tu- mour grade, estrogen and progesterone receptor status, p53 status, survival, and occurrence of relapse or metastasis. We found that MCM7 and SMC4 were the most frequently and significantly overexpressed genes in high grade tumours. These genes contain two well known cancer-associated miRNA clusters: miR25-93-106b and miR-15b/16- 2 respectively. In addition we identified six other miRNA host genes that were significantly downregulated in high grade tumours in all the data sets. Much less evidence is available in the literature about the involvement in cancer of the miRNAs contained in these genes (i.e., miR-218-1, miR-342, miR-483, miR-548f-2, miR-1245 and miR-1266 ). We measured the expression of the selected miRNAs by Real Time PCR on an independent cohort of 36 formalin-fixed paraffin-embedded (FFPE) samples, and we observed reduced expressions level of such miRNAs in high grade tumours. In particular, we found miR-342-3p, miR-342-5p, miR-483- 3p, and miR-483-5p to be the most significantly downregulated miRNAs. These miRNAs were also found to correlate with bad prognosis in grade 2 tumours. Finally we provided initial evidence that increased expression of miR-342-5p, but not miR-342-3p, induces apoptosis in the highly metastatic MDA-MB-231 breast cancer cell line.
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Smith, Daniel. "Electrochemical detection of microRNA." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/107718/.

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Members of the recently discovered family of short non-coding RNAs, termed microRNAs (miRNAs), regulate the expression of most genes encoded by the human genome by repressing translation of messenger RNAs to proteins. MiRNAs are stably expressed throughout the body and can be detected robustly and reproducibly by RT-qPCR in body fluids such as blood and urine. Alterations in circulating miRNA profiles have been associated with cancers of the brain, breast and liver, and miRNAs hold great promise as biomarkers of numerous other diseases. However, current methods for miRNA biomarker detection rely on laborious, expensive and expert techniques, and involve invasive biopsy acquisition. The research contained within this thesis focusses on the development of a non-invasive, inexpensive and rapid electrochemical analytical test to quantify miRNA in human urine samples. Therefore we describe how glassy carbon and disposable screen printed carbon electrodes (SPCEs), were modified through electropolymerisation of a naphthalene sulfonic acid derivative. DNA complementary to a target miRNA was attached and the sensor analysed via electrochemical methods using a ferri/ferrocyanide electrolyte. After hybridising with a miRNA target, this analysis was repeated and compared to the original DNA-only analysis to give a corresponding change. This was performed using buffered solutions and shown to be sensitive to 20 fM and selective against sequences with a single mismatch; urine analysis was also performed. The method was then adapted for use with screen printed electrodes, using a new chlorination solvent system, to a lowest detected concentration of 10 fM. The ink materials used for the production of the SPCEs were optimised and a new design developed to allow for multiple analyses on one sensor. A small number of diabetic kidney nephropathy (DKN) patient and healthy control urine samples were then analysed for biomarkers we have recently identified, comparing their relative expression levels.
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Books on the topic "MicroRNA"

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Ying, Shao-Yao, ed. MicroRNA Protocols. Totowa, NJ: Humana Press, 2006. http://dx.doi.org/10.1385/1597451231.

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Rani, Sweta, ed. MicroRNA Profiling. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6524-3.

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Santulli, Gaetano, ed. microRNA: Cancer. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-23730-5.

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Ying, Shao-Yao, ed. MicroRNA Protocols. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-083-0.

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Ying, Shao-Yao, ed. MicroRNA Protocols. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7601-0.

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Kye, Min Jeong, ed. MicroRNA Technologies. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7175-6.

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Rani, Sweta, ed. MicroRNA Profiling. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2823-2.

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Shao-Yao, Ying, ed. MicroRna protocols. Totowa, N.J: Humana Press, 2006.

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J, Rossi John, and Hannon Gregory J. 1964-, eds. MicroRNA methods. San Diego, Calif: Academic Press, 2007.

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service), SpringerLink (Online, ed. MicroRNA Interference Technologies. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg, 2009.

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Book chapters on the topic "MicroRNA"

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Patne, Ketki, and Rohini Muthuswami. "Controlling the Biogenesis of the Smallest Regulators." In MicroRNA, 1–20. Boca Raton : Taylor & Francis, 2018. | “A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.”: CRC Press, 2018. http://dx.doi.org/10.1201/b22195-1.

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Muiwo, Pamchui, Priyatama Pandey, and Alok Bhattacharya. "Computational Analysis of miRNAs, Their Target Sequences and Their Role in Gene Regulatory Networks." In MicroRNA, 21–38. Boca Raton : Taylor & Francis, 2018. | “A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.”: CRC Press, 2018. http://dx.doi.org/10.1201/b22195-2.

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Anand, Sneha, and Rentala Madhubala. "miRNAs: Small RNAs with Big Regulatory Functions in Parasitic Diseases." In MicroRNA, 39–56. Boca Raton : Taylor & Francis, 2018. | “A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.”: CRC Press, 2018. http://dx.doi.org/10.1201/b22195-3.

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Thirugnanasambantham, Krishnaraj, Villianur Ibrahim Hairul Islam, Subramanian Saravanan, Venugopal Senthil Kumar, Ganapathy Ashok, and Muthiah Chellappandian. "Role of miRNA in Multiple Sclerosis." In MicroRNA, 57–76. Boca Raton : Taylor & Francis, 2018. | “A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.”: CRC Press, 2018. http://dx.doi.org/10.1201/b22195-4.

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Paul, Jaishree, and Swati Valmiki. "miRNA Dysregulation in Inflammatory Bowel Disease and Its Consequences." In MicroRNA, 77–96. Boca Raton : Taylor & Francis, 2018. | “A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.”: CRC Press, 2018. http://dx.doi.org/10.1201/b22195-5.

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Bhattacharyya, Malay, and Sanghamitra Bandyopadhyay. "Involvement of MicroRNAs in Alzheimer’s Disease." In MicroRNA, 97–112. Boca Raton : Taylor & Francis, 2018. | “A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.”: CRC Press, 2018. http://dx.doi.org/10.1201/b22195-6.

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Sarangdhar, Mayuresh Anant, and Beena Pillai. "MicroRNAs in Neurogenesis and Neurodegeneration." In MicroRNA, 113–42. Boca Raton : Taylor & Francis, 2018. | “A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.”: CRC Press, 2018. http://dx.doi.org/10.1201/b22195-7.

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Pant, Kishor, Amit Kumar Mishra, and Senthil Kumar Venugopal. "MicroRNAs in the Progression of Hepatocellular Carcinoma." In MicroRNA, 143–72. Boca Raton : Taylor & Francis, 2018. | “A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.”: CRC Press, 2018. http://dx.doi.org/10.1201/b22195-8.

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Vinchure, Omkar, and Ritu Kulshreshtha. "MicroRNA Regulation of Invasive Phenotype of Glioblastoma." In MicroRNA, 173–200. Boca Raton : Taylor & Francis, 2018. | “A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.”: CRC Press, 2018. http://dx.doi.org/10.1201/b22195-9.

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Langenberger, David, Sebastian Bartschat, Jana Hertel, Steve Hoffmann, Hakim Tafer, and Peter F. Stadler. "MicroRNA or Not MicroRNA?" In Advances in Bioinformatics and Computational Biology, 1–9. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-22825-4_1.

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Conference papers on the topic "MicroRNA"

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Zhao, Xing-Hua, Jia-Feng Yu, Yan-ke Tang, and Ji-Hua Wang. "G-MicroRNA: A New Tool for MicroRNA Genomics." In 2009 1st International Conference on Information Science and Engineering (ICISE 2009). IEEE, 2009. http://dx.doi.org/10.1109/icise.2009.614.

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Spivack, Simon D. "MicroRNA Affinity Assay." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2298.

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Kim, Jungeun, Ying Zhang, Fadila Guessous, and Roger Abounader. "Abstract 3165: microRNA-148a: A novel oncogenic microRNA in glioblastoma." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3165.

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Nikitin, A. O., A. M. Timofeeva, S. E. Sedykh, and G. A. Nevinsky. "ANTIBODY ACTIVITY IN MICRORNA HYDROLYSIS: ROLE IN GENE REGULATION IN VIRAL INFECTIONS." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-351.

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Antibodies with catalytic activity, hydrolyzing DNA, RNA and some oligopeptides have been described in a number of viral and autoimmune diseases. Antibodies with RNA-hydrolyzing activity can be important in the degradation of microRNAs and, as a consequence, in the change in the regulation of genes carried out with the help of microRNAs. The aim of this work is to investigate the activity of antibodies of HIV-infected patients in microRNA hydrolysis.
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Zhurko, P. T., I. V. Koktysh, and R. M. Smolyakova. "MicroRNA let-7e AND miR-140 AS BIOMARKERS OF DEFORMING JOINT DISEASES." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-55-58.

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The circulating microRNAs (let-7e and miR-140) expression levels were studied in the plasma of peripheral blood and synovial fluid of patients with gonarthrosis and coxarthrosis. There was a statistically significant decrease in the expression of miR-140 in synovial fluid and let-7e in the peripheral blood of patients with osteoarthritis (p <0.05). MicroRNA let-7e characterizes comorbidity and indicates the development of metabolic syndrome. It was established a correlation between the microRNAs expression levels and the disease severity.
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Narcı, Kübra, Hasan Oğul, and Mahinur Akkaya. "Sequence-based MicroRNA Clustering." In 7th International Conference on Bioinformatics Models, Methods and Algorithms. SCITEPRESS - Science and and Technology Publications, 2016. http://dx.doi.org/10.5220/0005552901070116.

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Malmhäll, Carina, Sahar Alawieh, Jan Lötvall, and Madeleine Rådinger. "MicroRNA-146a and microRNA-155 expression in induced sputum of allergic asthmatics." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa2552.

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Zaman, Mohd Saif, Guoren Deng, Varahram Shahryari, Sharanjot Saini, Shahana Majid, Kamaldeep Singh, Herman Sandhu, Inik Chang, Yuichiro Tanaka, and Rajvir Dahiya. "Abstract 128: MicroRNA-23b acts as an oncogenic microRNA in renal cancer." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-128.

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Dracheva, K. V., I. A. Pobozheva, K. A. Anisimova, Z. M. Hamid, S. G. Balandov, D. I. Vasilevsky, S. N. Pchelina, and V. V. Miroshnikova. "MICRORNA OF SERUM EXTRACELLULAR VESICLES AS MARKERS OF TYPE 2 DIABETES MELLITUS DEVELOPMENT IN OBESITY." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-317.

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The study involved microRNA profiling of extracellular vesicles (EV) secreted by adipose tissue in obese patients and in a control group, followed by content analysis of microRNAs demonstrating differences in adipose tissue EV, in serum EV in obese patients with/without T2DM and in the control group. We found 2 microRNAs: hsa-miR-551b-3p and hsa-miR-302d-3p, which may be markers of T2DM development in obesity.
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Tran, Nhat, Vinay Abhyankar, KyTai Nguyen, Ishfaq Ahmad, Jon Weidanz, and Jean Gao. "MicroRNA dysregulational synergistic network: Learning context-specific MicroRNA dysregulations in lung cancer subtypes." In 2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2017. http://dx.doi.org/10.1109/bibm.2017.8217640.

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Reports on the topic "MicroRNA"

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Hammond, Scott M. MicroRNA Inhibitors as Anticancer Therapies. Fort Belvoir, VA: Defense Technical Information Center, August 2007. http://dx.doi.org/10.21236/ada475785.

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Galaktionov, Konstantin. MicroRNA and Breast Cancer Progression. Fort Belvoir, VA: Defense Technical Information Center, August 2007. http://dx.doi.org/10.21236/ada480199.

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Shukla, Girish C. MicroRNA Targets of Human Androgen Receptor. Fort Belvoir, VA: Defense Technical Information Center, May 2013. http://dx.doi.org/10.21236/ada589690.

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Hsieh, Jer-Tsong, and Betty Diamond. Role of MicroRNA in Aggressive Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, July 2014. http://dx.doi.org/10.21236/ada611002.

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Hsieh, Jer-Tsong. Role of MicroRNA in Aggressive Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, July 2013. http://dx.doi.org/10.21236/ada591960.

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Watabe, Kounosuke. DCIS-Specific MicroRNA in Cancer Stem Cell. Fort Belvoir, VA: Defense Technical Information Center, September 2011. http://dx.doi.org/10.21236/ada554452.

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Novina, Carl. Dysregulated microRNA Activity in Shwachman-Diamond Syndrome. Fort Belvoir, VA: Defense Technical Information Center, July 2015. http://dx.doi.org/10.21236/ada624270.

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Bock, Cathryn. MicroRNA in Prostate Cancer Racial Disparities and Aggressiveness. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada613715.

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Padgett, Richard W. Role of MicroRNA Genes in Breast Cancer Progression. Fort Belvoir, VA: Defense Technical Information Center, August 2006. http://dx.doi.org/10.21236/ada462585.

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Padgett, Richard W. Role of MicroRNA Genes in Breast Cancer Progression. Fort Belvoir, VA: Defense Technical Information Center, August 2007. http://dx.doi.org/10.21236/ada482281.

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