Journal articles: 'Micromeritics'

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Himawan, A., N. J. N. Djide, M. Mudjahid, A. D. I. Lukita, A. Arjuna, and Aliyah. "Physicochemical and Micromeritics Properties of Ketoprofen-Tartaric Acid Binary System." Journal of Physics: Conference Series 1341 (October 2019): 072004. http://dx.doi.org/10.1088/1742-6596/1341/7/072004.

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Paramakrishnan, N., S. Jha, and K. Jayaram Kumar. "Effect of carboxymethylation on physicochemical, micromeritics and release characteristics of Kyllinga nemoralis starch." International Journal of Biological Macromolecules 92 (November 2016): 543–49. http://dx.doi.org/10.1016/j.ijbiomac.2016.07.039.

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Kedia, Kishori, and Sarika Wairkar. "Improved micromeritics, packing properties and compressibility of high dose drug, Cycloserine, by spherical crystallization." Powder Technology 344 (February 2019): 665–72. http://dx.doi.org/10.1016/j.powtec.2018.12.068.

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Ayon, Navid Jubaer, Ikramul Hasan, Md Shfiqul Islam, and Md Selim Reza. "Preparation and characterization of Gliclazide incorporated Cellulosic Microspheres: studies on drug release, compatibility and micromeritics." Dhaka University Journal of Pharmaceutical Sciences 13, no. 2 (February 5, 2015): 149–66. http://dx.doi.org/10.3329/dujps.v13i2.21893.

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Polymeric microspheres of gliclazide were prepared to provide sustained release delivery of gliclazide to aid in continuous therapy with high margin of safety. Gliclazide was microencapsulated with different polymers namely HPMC K100LV, Ethocel (20 cps) and HPMC K100M by emulsion solvent evaporation technique using acetone as internal phase and liquid paraffin as external phase. Seventeen formulations were prepared using different drug loading and polymeric ratio of which nine formulations were prepared by a 32 full factorial design. Each formulation was evaluated for flow properties, particle size, surface morphology, drug entrapment efficiency, drug release and compatibility. Yield (%) for every batch of microspheres was measured. Flow properties of the microspheres were examined by determining bulk density, tapped density, Carrs compressibility index, Hausner ratio and angle of repose. Particle size distribution was examined by sieving and particle size analyzer. Surface morphology was determined by scanning electron microscopy (SEM). In-vitro drug release was studied in a paddle type dissolution apparatus (USP Type II Dissolution Apparatus) for a period of 8 hours at 37°C using phosphate buffer ( pH 7.4). FTIR and DSC studies established compatibility of the drug with the polymers. Microspheres prepared with Ethocel (20 cps) and HPMC K100M were free flowing than those prepared only with HPMC K100LV. Entrapment efficiencies were within 75.88-99.69%. Microspheres prepared with Ethocel (20 cps) and HPMC K100M showed more sustained release when compared to microspheres prepared with HPMC K100LV only. Increase in drug loading resulted in increased drug release for the microspheres. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism ranging from diffusion controlled to anomalous type. Ethocel and HPMC K100M in a ratio of 1:3 exhibited better sustained release properties than 1:1 and 3:1 ratios. The release rate of gliclazide from microspheres prepared with Ethocel (20 cps) and HPMC K100M was less than the release rate of gliclazide from microspheres prepared with HPMC K100LV, demonstrating Ethocel and HPMC K100M as suitable polymeric blend for preparing the controlled release formulation for gliclazide whereas, HPMC K100LV was found not suitable candidate when used alone as a polymer. DOI: http://dx.doi.org/10.3329/dujps.v13i2.21893 Dhaka Univ. J. Pharm. Sci. 13(2): 149-166, 2014 (December)

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Viswanathan, Chelakara L., Sushrut K. Kulkarni, and Dhanashri R. Kolwankar. "Spherical agglomeration of mefenamic acid and nabumetone to improve micromeritics and solubility: A technical note." AAPS PharmSciTech 7, no. 2 (June 2006): E122—E125. http://dx.doi.org/10.1208/pt070248.

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Ma, Cheng, Wenhao Wang, Zhengwei Huang, Xiaona Chen, Weifen Ye, Kewei Pan, Ruhua Ma, et al. "Effect of the cargo lipophilicity on powder micromeritics properties of drug-loaded solid lipid microparticles." Journal of Drug Delivery Science and Technology 51 (June 2019): 614–20. http://dx.doi.org/10.1016/j.jddst.2019.03.025.

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Pryszcz, Adrian, Barbora Grycová, Ivan Koutník, and Veronika Blahůšková. "Characterization of Tar Deposits, Extraction and Sorption Properties." GeoScience Engineering 62, no. 2 (June 1, 2016): 1–4. http://dx.doi.org/10.1515/gse-2016-0010.

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Abstract The main goal of this paper was to characterize and find a useful solution for the decomposition of tar deposits. For the experimental part, tar deposits, formed by polymerization and condensation reactions, were chosen from a storage tank for tars. At first the initial analyses of tar deposits (elemental, thermogravimetric, and calorimetric analyses) were performed. After the characterization, the tar deposits were extracted in the Soxhlet extractor by acetone, toluene, and quinolone and activated with potassium hydroxide. As the final step of this work, the sorption characterization on the 3Flex Surface Characterization Analyzer (Micromeritics) was performed. The specific surface area of the samples was evaluated using two methods - a single point measurement at p/p0=0.2 and BET method. Micropore and external surface areas were calculated based on a t-plot analysis (carbon black model).

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RILEY, C., S. ADEBAYO, A. WHEATLEY, and H. ASEMOTA. "The interplay between yam (Dioscorea sp.) starch botanical source, micromeritics and functionality in paracetamol granules for reconstitution." European Journal of Pharmaceutics and Biopharmaceutics 70, no. 1 (September 2008): 326–34. http://dx.doi.org/10.1016/j.ejpb.2008.03.001.

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Kaur, Harjeet, Baldeep Kumar, Amitava Chakrabarti, Bikash Medhi, Manish Modi, Bishan Dass Radotra, Ritu Aggarwal, and Vivek Ranjan Sinha. "A New Therapeutic Approach for Brain Delivery of Epigallocatechin Gallate: Development and Characterization Studies." Current Drug Delivery 16, no. 1 (November 27, 2018): 59–65. http://dx.doi.org/10.2174/1567201815666180926121104.

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Background: Blood-brain permeability is the primary concern when dealing with the biodistribution of drugs to the brain in neurological diseases. Objective: The purpose of the study is to develop the nanoformulation of Epigallocatechin gallate (EGCG) in order to improve its bioavailability and penetration into the brain. Methods: EGCG loaded Solid Lipid Nanoparticles (SLNs) have been developed using microemulsification method and pharmacological assessments were performed. Results: Surface morphology and micromeritics analysis showed the successful development of EGCG loaded solid lipid nanoparticles with an average size of 162.4 nm and spherical in shape. In vitro release studies indicated a consistent and slow drug release. Pharmacological evaluation of SLN-EGCG demonstrated a significant improvement in cerebral ischemia-induced memory impairment. Conclusion: The results indicate that the EGCG loaded SLNs provide a potential drug delivery system for improved delivery of EGCG to the brain, hence, enhancing its brain bioavailability.

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Rashad, Amira A., Sara Nageeb El-Helaly, Randa T. Abd El Rehim, and Omaima N. El-Gazayerly. "Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strength." Acta Pharmaceutica 69, no. 3 (September 1, 2019): 381–98. http://dx.doi.org/10.2478/acph-2019-0022.

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Abstract Reduced bioavailability of azelnidipine is related to its poor aqueous solubility and extensive first-pass metabolism, which hinder its efficacy. These problems were addressed by implementing (1) a liquisol technique for promoting the dissolution rate in a controlled-release manner and (2) a core-in-cup bucco-adhesive drug delivery system as an alternative to the oral route. A 33 factorial design was used to study the effects of polymer type (sodium carboxymethyl cellulose (CMC Na), chitosan, or Carbomer P940) concentration (5, 10 or 15 %) and preparation technique (simple mix, liquisol or wet granulation) on the dissolution and mucoadhesion of core-in-cup azelnidipine buccoadhesive tablets. Tablet micromeritics, swelling index, mucoadhesive strength and in vitro release were characterized. Statistical analyses of these factors show ed significant effects on the studied responses, where F#16 prepared by the liquisol technique and containing 15 % CMC Na was chosen with an overall desirability of 0.953.

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Amore, Ricardo, Clóvis Pagani, Michel Nicolau Youssef, Camillo Anauate Netto, and Hugo Roberto Lewgoy. "Polymerization shrinkage evaluation of three packable composite resins using a gas pycnometer." Pesquisa Odontológica Brasileira 17, no. 3 (September 2003): 273–77. http://dx.doi.org/10.1590/s1517-74912003000300013.

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Modern restorative dentistry has been playing an outstanding role lately since composite resins, allied to adhesive systems, have been widely applied on anterior and posterior teeth restorations. The evolution of composite resins has mostly been verified due to the improvement of their aesthetic behavior and the increase in their compressive and abrasive strengths. In spite of these developments, the polymerization shrinkage inherent to the material has been a major deficiency that, so far, has been impossible to avoid. Using a gas pycnometry, this research investigated the polymerization shrinkage of three packable composite resins: Filtek P60 (3M), Prodigy Condensable (Kerr), and SureFil (Dentsply/Caulk), varying the distance from the light source to the surface of the resins (2 mm or 10 mm). The pycnometer Accupyc 1330 (Micromeritics, USA) precisely records helium displacement, allowing fast and reliable measurements of the volume of composite resin immediately before and after polymerization, without interference of temperature or humidity. Results were not found to be statistically different for the three tested resins, either for 2 mm or 10 mm-distance from the light source to the composite surface.

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Goñi, S., and A. Guerrero. "Role of Combined Water for Determining the Mechanical Behaviour of Class C Fly Ash Belite Cements." Materials Science Forum 636-637 (January 2010): 1252–57. http://dx.doi.org/10.4028/www.scientific.net/msf.636-637.1252.

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The physically-chemically bounded water is an important parameter directly related to the gain of mechanical strength during the hydration of cements. In this work, quantitative determinations of the physically - chemically bounded water of two types of belite cements, called FABC-2-W and FABC-2-N, were carried out by means of thermogravimetry analyses during a period of 180 days of hydration. The hydrated products were characterized by X-ray diffraction and BET surface area. Important direct quantitative correlations were obtained between the combined water and technological characteristics of cements such as the compressive mechanical strength or the BET surface area. TG measurements for hydrated FABC-2-W and FABC-2-N cements were carried out in flowing nitrogen on a TGA/SDTA 851 (Mettler) in the temperature range from 25 to 1100°C with heating rate of 10 °C min-1 and nitrogen flow rate of 25 mL min-1. BET surface area was measured using nitrogen adsorption at 77 K, on an ASAP 2010 (Micromeritics).

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Shahgaldi, Samaneh, Zahira Yaakob, Norazrina Mat Jali, Dariush Jafar Khadem, Wan Ramli Wan Daud, and Edy Herianto Majlan. "Influence of Iron Oxide Nano Particles on Electrospun Poly (Vinylidene Fluride)-Based Carbon Nanofibers on Hydrogen Storage." Key Engineering Materials 471-472 (February 2011): 1184–89. http://dx.doi.org/10.4028/www.scientific.net/kem.471-472.1184.

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Electrospun Poly (vinylidene fluoride) (PVdF) fine fiber of 100-300 nm in diameter in ribbon shape was synthesized through the electrospinning process via sol-gel. In order to synthesize infusible nanofibers all processing of dehydrofluorination and carbonization was investigated. Iron nanoparticles was doped with PVDF nanofibers in order to be effective in surface area, and porosity to increase the hydrogen storage. The composition, morphology, structure and surface area of PVDF/Iron Oxide nanofibers were investigated by thermo gravimetric analysis (TGA) to determinate the temperature of possible decomposition and crystallinity, scanning electron microscopy (SEM), transmission electron microscopy (TEM), Micromeritics (ASAP2020) used to study the textural properties of the sample, like surface area, total pore volume, and micro pore volume. The result shows that the PVDF without dehydrofluorination treatment for infusibility become melt at around 160 °C. By adding the iron oxide nanoparticles as a catalyst it can improve the characteristic of the carbon fiber for hydrogen storage. In best of our knowledge, PVDF doping with iron oxide investigated for first time.

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Rodríguez-Dorado, Rosalía, Clara López-Iglesias, Carlos García-González, Giulia Auriemma, Rita Aquino, and Pasquale Del Gaudio. "Design of Aerogels, Cryogels and Xerogels of Alginate: Effect of Molecular Weight, Gelation Conditions and Drying Method on Particles’ Micromeritics." Molecules 24, no. 6 (March 17, 2019): 1049. http://dx.doi.org/10.3390/molecules24061049.

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Processing and shaping of dried gels are of interest in several fields like alginate aerogel beads used as highly porous and nanostructured particles in biomedical applications. The physicochemical properties of the alginate source, the solvent used in the gelation solution and the gel drying method are key parameters influencing the characteristics of the resulting dried gels. In this work, dried gel beads in the form of xerogels, cryogels or aerogels were prepared from alginates of different molecular weights (120 and 180 kDa) and concentrations (1.25, 1.50, 2.0 and 2.25% (w/v)) using different gelation conditions (aqueous and ethanolic CaCl2 solutions) and drying methods (supercritical drying, freeze-drying and oven drying) to obtain particles with a broad range of physicochemical and textural properties. The stability of physicochemical properties of alginate aerogels under storage conditions of 25 °C and 65% relative humidity (ICH-climatic zone II) during 1 and 3 months was studied. Results showed significant effects of the studied processing parameters on the resulting alginate dried gel properties. Stability studies showed small variations in aerogels weight and specific surface area after 3 months of storage, especially, in the case of aerogels produced with medium molecular weight alginate.

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Nwabor, Ozioma Forstinus, Sudarshan Singh, Dwi Marlina, and Supayang Piyawan Voravuthikunchai. "Chemical characterization, release, and bioactivity of Eucalyptus camaldulensis polyphenols from freeze-dried sodium alginate and sodium carboxymethyl cellulose matrix." Food Quality and Safety 4, no. 4 (August 28, 2020): 203–12. http://dx.doi.org/10.1093/fqsafe/fyaa016.

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Abstract Crude ethanolic extract of Eucalyptus camaldulensis was encapsulated with sodium alginate–sodium carboxymethyl cellulose (CMC) using freeze-drying techniques. The microcapsules were characterized for particle size, morphology, physicochemical parameters, and micromeritics properties. Antioxidant and antimicrobial activities of the microcapsules were also demonstrated. Results revealed an irregular-shaped microparticles with a mean diameter ranging from 6.7 to 26.6 µm. Zeta potential and polydispersity index ranged from −17.01 to 2.23 mV and 0.34 to 0.49, respectively. Percentage yield ranged between 70.4 and 81.5 per cent whereas encapsulation efficiency ranged between 74.2 ± 0.011 and 82.43 ± 0.77 per cent. Swelling index and solubility varied inversely with extract concentration, with a range of 54.4%–84.0% and 18.8%–22.2%, respectively. Antioxidant activities varied directly with the concentration of the extract. Minimum inhibitory and minimum bactericidal concentrations of the microcapsules against Gram-positive foodborne pathogens ranged from 0.19 to 3.12 and 0.19–12.25 mg/ml, respectively. The Higuchi model indicated a time-dependent, delayed, and regulated release of polyphenols at 37°C. The results suggested that alginate–CMC possessed good encapsulant properties that preserved the bioactive extract, thus might be employed for application of natural products in food systems.

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Auriemma, Giulia, Andrea Cerciello, Rita P. Aquino, Pasquale Del Gaudio, Bruno M. Fusco, and Paola Russo. "Pectin and Zinc Alginate: The Right Inner/Outer Polymer Combination for Core-Shell Drug Delivery Systems." Pharmaceutics 12, no. 2 (January 21, 2020): 87. http://dx.doi.org/10.3390/pharmaceutics12020087.

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Core-shell beads loaded with betamethasone were developed using co-axial prilling as production technique and pectin plus alginate as polymeric carriers. During this study, many operative conditions were intensively investigated to find the best ones necessary to produce uniform core-shell particle systems in a reproducible way. Particularly, feed solutions’ composition, polymers mass ratios and the effect of the main process parameters on particles production, micromeritics, inner structure, drug loading and drug-release/swelling profiles in simulated biological fluids were studied. The optimized core-shell formulation F5 produced with a pectin core concentration of 4.0% w/v and an alginate shell concentration of 2.0% w/v (2:1 core:shell ratio) acted as a sustained drug delivery system. It was able to reduce the early release of the drug in the upper part of the gastro-intestinal tract for the presence of the zinc-alginate gastro-resistant outer layer and to specifically deliver it in the colon, thanks to the selectivity of amidated low methoxy pectin core for this district. Therefore, these particles may be proposed as colon targeted drug delivery systems useful for inflammatory bowel disease (IBD) therapy.

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Zhang, Qian, Bing Lin, Junming Hong, and Chang-Tang Chang. "Removal of ammonium and heavy metals by cost-effective zeolite synthesized from waste quartz sand and calcium fluoride sludge." Water Science and Technology 75, no. 3 (October 31, 2016): 587–97. http://dx.doi.org/10.2166/wst.2016.508.

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This study focuses on the effectiveness of zeolite (10% CF-Z [0.5]) hydrothermally synthesized from waste quartz sand and calcium fluoride (CF) for ammonium ion and heavy metal removal. Zeolite was characterized through powder X-ray diffraction, Fourier-transform infrared spectroscopy, micromeritics N2 adsorption/desorption analysis, and field emission scanning electron microscopy. The effects of CF addition, Si/Al ratio, initial ammonium concentration, solution pH, and temperature on the adsorption of ammonium on 10% CF-Z (0.5) were further examined. Results showed that 10% CF-Z (0.5) was a single-phase zeolite A with cubic-shaped crystals and 10% CF-Z (0.5) efficiently adsorbs ammonium and heavy metals. For instance, 91% ammonium (10 mg L−1) and 93% lead (10 mg L−1) are removed. The adsorption isotherm, kinetics, and thermodynamics of ammonium adsorption on 10% CF-Z (0.5) were also theoretically analyzed. The adsorption isotherm of ammonium and lead on 10% CF-Z (0.5) in single systems indicated that Freundlich model provides the best fit for the equilibrium data, whereas pseudo-second-order model best describes the adsorption kinetics. The adsorption degree of ions on 10% CF-Z (0.5) in mixed systems exhibits the following pattern: lead > ammonium > cadmium > chromium.

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Şahbaz, Deniz Akın, and Caglayan Acikgoz. "Cross-linked chitosan/marble powder composites for the adsorption of Dimozol Blue." Water Science and Technology 76, no. 10 (August 3, 2017): 2776–84. http://dx.doi.org/10.2166/wst.2017.447.

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Abstract Cross-linked chitosan(C)/marble powder (M) composites with different weight ratio percentage (C100M0, C70M30, C50M50, and C30M70) were prepared from marble powder and chitosan and cross-linked using glutaraldehyde. The morphology and the surface area of the chitosan/marble powder composites were also characterized with a scanning electron microscope (SEM) and Micromeritics (ASAP 2020) BET (Brunauer, Emmett and Teller) instrument, respectively. To evaluate the adsorption behaviour of the chitosan/marble powder composites, 0.1 g adsorbent was added into 50 mL Diamozol Blue BRF %150 (C.I. Reactive Blue 221) solution with fixed concentrations (60 mg/L). At equilibrium, the adsorption capacity of C100M0, C70M30 and C50M50 for Dimozol Blue was about 27 mg/g and significantly greater than that of C30M70. C50M50 composite was more economical than C100M0 and C70M30 due to the higher marble powder content, and hence was selected as an adsorbent for the removal of Dimozol Blue from aqueous solution. The adsorption kinetics and equilibrium isotherms of Dimozol Blue onto the chitosan/marble powder composites from aqueous solution were investigated. The studies revealed that Dimozol Blue dye adsorption was described well by the pseudo-second-order and Freundlich isotherm models. The results of this study indicated the applicability of the chitosan/marble powder composites for removing industrial dyes from aqueous solution.

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Migoha, C. O., M. Ratansi, E. Kaale, and G. Kagashe. "Preformulation Studies for Generic Omeprazole Magnesium Enteric Coated Tablets." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/307032.

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Preformulation is an important step in the rational formulation of an active pharmaceutical ingredient (API). Micromeritics properties: bulk density (BD) and tapped density (TD), compressibility index (Carr’s index), Hauser’s ratio (H), and sieve analysis were performed in order to determine the best excipients to be used in the formulation development of omeprazole magnesium enteric coated tablets. Results show that omeprazole magnesium has fair flow and compressibility properties (BD 0.4 g/mL, TD 0.485 g/mL, Carr’s index 17.5%, Hauser’s ratio 1.2, and sieve analysis time 5 minutes). There were no significant drug excipient interactions except change in colour in all three conditions in the mixture of omeprazole and aerosil 200. Moisture content loss on drying in all three conditions was not constant and the changes were attributed to surrounding environment during the test time. Changes in the absorption spectra were noted in the mixture of omeprazole and water aerosil only in the visible region of 350–2500 nm. Omeprazole magnesium alone and with all excipients showed no significant changes in omeprazole concentration for a 30-day period. Omeprazole magnesium formulation complies with USP standards with regards to the fineness, flowability, and compressibility of which other excipients can be used in the formulation.

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Colpas, Fredy, Arnulfo Tarón, and Waldyr Fong. "Analisis del desarrollo textural de carbones activados preparados a partir de zuro de maíz." Temas Agrarios 20, no. 1 (August 24, 2016): 103–12. http://dx.doi.org/10.21897/rta.v20i1.752.

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Algunos residuos agrícolas pueden ser útiles para producir materiales adsorbentes como son los de carbones activados. Tal es el caso del Zuro de maíz, el cual fue utilizado como material de partida en esta investigación, Para la preparación de carbón activado, inicialmente el zuro libre de granos de maíz es carbonizado a temperatura de 400 °C, posteriormente los carbonizados fueron activados químicamente con ácido ortofosfórico, los carbones activados obtenidos fueron modificados con ácido nítrico y peróxido de hidrógeno, previo calentamiento a 600°C para observar su desarrollo textural. Los sólidos fueron caracterizados a través de un análisis, para la determinación del área superficial se realizaron isotermas de adsorción mediante el método BET, utilizando equipo Micromeritics Gemini 2375. La activación con ácido ortofosfórico aumentó el contenido de carbono y disminuyó el contenido de oxígeno. El área de microporos se incrementó por el tratamiento con HNO3 y H 2O2 desde 278,3 m2 g-1 hasta 401,7m2 g-1 y 446,4 m2g-1 respectivamente y la mayor parte del área total desarrollada correspondió a microporos. El pH generado por los carbones fue aproximadamente 3, el cual se determinó en soluciones acuosas luego de lavado con agua destilada; así mismo, estos materiales mostraron valores en los grupos COOH hasta 2,12 meq g-1.

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Tan Peng Jun, Patrick, Wan Nur Aisyah Wan Osman, Shafirah Samsuri, Juniza Md Saad, Muhamad Fadli Samsudin, and Eduard Hernández Yáñez. "Factory Tea Waste Biosorbent for Cu(II) and Zn(II) Removal from Wastewater." E3S Web of Conferences 287 (2021): 04006. http://dx.doi.org/10.1051/e3sconf/202128704006.

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Recent studies have shown great interest toward heavy metal removal due to its hazardous and non-biodegradable properties. Many approaches have been used for this purpose and one of them is adsorption. In this study, several experiments were carried out to investigate the feasibility of factory tea waste as a biosorbent in a fixed-bed adsorption column for heavy metal removal (zinc and copper) in wastewater. The results highlighted that zinc has better performance compared to copper in terms of the effect of initial ion concentration, pH value, and the mixed ions with respect to the removal efficiency. Zinc showed higher removal efficiency and adsorption capacity at the initial metal ion concentration of 200 mg/L, which are 99.21% and 39.68 mg/mg compared to copper. Meanwhile, for the effect of pH values and mixed ion concentration, zinc also showed slightly higher removal efficiency which are 99.91% and 98.47%, respectively compared to copper. However, both zinc and copper showed a better fit to the Langmuir isotherm. The factory tea waste was characterized using Micromeritics ASAP 2020 instrument and results showed that the factory tea waste biosorbent consists of mesopores with the diameter and width of 4.85205 and 2.546985 nm, respectively.

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Jelvehgari, Mitra, Fatemeh Atapour, and Ali Nokhodchi. "Micromeritics and release behaviours of cellulose acetate butyrate microspheres containing theophylline prepared by emulsion solvent evaporation and emulsion non-solvent addition method." Archives of Pharmacal Research 32, no. 7 (July 2009): 1019–28. http://dx.doi.org/10.1007/s12272-009-1707-y.

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SAIM, S. "Isomerization of 1-Hexene over Pt/$gamma;-Al2O3 catalyst: Reaction mixture density and temperature effects on catalyst effectiveness factor, coke laydown, and catalyst micromeritics." Journal of Catalysis 131, no. 2 (October 1991): 445–56. http://dx.doi.org/10.1016/0021-9517(91)90278-c.

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Patil, Arun Trambak, Deepak Shamrao Khobragade, Sandip Annaji Chafle, Amol Prasadrao Ujjainkar, Sudhir Niranjanrao Umathe, and Champalal Laxminarayan Lakhotia. "Development and evaluation of a hot-melt coating technique for enteric coating." Brazilian Journal of Pharmaceutical Sciences 48, no. 1 (March 2012): 69–77. http://dx.doi.org/10.1590/s1984-82502012000100008.

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Conventional enteric coating requires the use of organic based polymers which are equally hazardous to the environment and operating personnel. Hot-melt coating avoids the use of solvents and is a safer and time-saving process. The present study was designed to assess the efficacy of hot-melt coating (HMC) as an enteric coating technique. Pellets prepared by extrusion spheronization were selected as the core formulation for a model of the gastric irritant drug diclofenac sodium (DFS) because of their innate advantages over single-unit formulations. Stearic acid (SA) and palmitic acid (PA) were evaluated as enteric hot-melt coating materials. HMC was carried out in a specially modified coating pan by applying SA and PA in molten state onto preheated pellets to achieve a coating level of 5-15 %w/w. Hot-melt coated pellets were evaluated for disintegration pH and in vitro dissolution in the pH range 1.2 to 6.8, along with basic micromeritics. SEM of coated pellets showed a uniform and smooth coating. These results indicated that HMC of both SA and PA exhibited very good enteric coating ability. The coated pellets showed negligible drug release in acidic pH. As the pellets were subsequently transferred to a higher pH level, a gradual increase in release of the drug from the pellets was observed with increasing pH of the dissolution media. The release was dependent upon coating extent, providing sustained enteric release as opposed to abrupt release with mixed release kinetics.

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Maurya, Harikesh, and Tirath Kumar. "FORMULATION, STANDARDIZATION, AND EVALUATION OF POLYHERBAL DISPERSIBLE TABLET." International Journal of Applied Pharmaceutics 11, no. 1 (January 9, 2019): 158. http://dx.doi.org/10.22159/ijap.2019v11i1.30113.

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Objective: The study was designed as formulation, standardization, and evaluation of polyherbal dispersible tablet prepared for the management of kidney disorders. To overcome the problem of dyspepsia in geriatric patients by the use of polyherbal dispersible tablets.Methods: Dispersible tablets were prepared using aqueous root extract powder of the selected plant viz. A. officinalis, B. diffusa, C. papaya, C. fistula, C. intybus, F. hispida, F. indica, C. nurvala, S. virgaurea, and V. negundo with the help of superdisintegrant addition technique using crospovidone, sodium starch glycolate and croscarmellose sodium in different percentage. Evaluation assessments such as the substantial test, weight variation, hardness, friability, content uniformity, disintegration, in vitro dispersion, stability study and IR compatibility were carried out.Results: Micromeritics of extracts powder were determined for all formulation, which signifying good flow properties. The substantial examination was established, which comply with official requirements for uniformity test, and the drug content was close to 100% in all formulations. Disintegration time was observed for all formulation in which the polyherbal formulation-3 (PHF-3) showing 1.10±0.10 min; during in vitro dispersion time, all formulation showed appropriate dispersion in which the PHF-3 captivating 2.00±0.45 min only. The IR compatibility shows none chemical interaction between the extracts and excipients.Conclusion: The PHF-3 showed satisfactory disintegration and in vitro dispersion time due to crospovidone and reported as the best formulation. The stability study and IR compatibility validate the PHF may represent new easily swallow dispersible tablet that may enhance drug permeability and advance bioavailability for nephrotic patients.

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Maghsoodi, Maryam, Seyed hassan Montazam, Hossein Rezvantalab, and Mitra Jelvehgari. "Response Surface Methodology for Optimization of Process Variables of Atorvastatin Suspension Preparation by Microprecipitation Method Using Desirability Function." Pharmaceutical Sciences 26, no. 1 (March 10, 2020): 61–74. http://dx.doi.org/10.34172/ps.2019.52.

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Background : Atorvastatin (AT), as a synthetic lipid-lowering agent, is a highly crystalline substance having poor solubility and low bioavailability. The objective of the present research was to improve the microprecipitation method of AT suspension preparation. Methods: Microprecipitation parameters were improved using Box-Behnken experimental design method. The suspension was formulated with Brij 35 (stabilizer agent) using methanol as solvent and water as non-solvent, respectively. DSC, XRD, FTIR studies were performed for characterization of the microcrystals. With the aim of evaluating the effect of independent variables, the amounts of organic solvent (X1), emulsifier concentration (X2), stirring rate (X3), and volume of aqueous solvent (X4) on dependent variables, drug content (DC,) particle size (PS), drug released after 5 minutes (Q5), Gibbs free energy change (ΔG°tr), crystal yield (CY) and saturated solubility (Ss), a full factorial was used. Results: The results of DSC, XRD, and FTIR showed that there was not any interaction between AT and Brij 35. This research demonstrated a reduction in crystallinity in agglomerates. The microcrystals showed that micromeritics characteristics were significantly improved compared to pure AT. The content of drug and yield crystal was in the limit of 42.58-110.24% and 58.33-98.18% in all formulations, respectively. It was shown that the prepared microcrystals had a higher rate of release compared to the untreated AT powder (P< 0.05). Size reduction of AT is needed for improving the solubility. Solubility and drug release rates of At was enhanced with the microprecipitation method. Conclusion: The results showed that microcrystals significantly increased AT dissolution rate.

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Prashant Singh and Ritu M. Gilgotra. "Formulation and evaluation of guar gum based matrix tableted glibenclamide microspheres." International Journal of Research in Pharmaceutical Sciences 11, no. 2 (May 15, 2020): 2445–57. http://dx.doi.org/10.26452/ijrps.v11i2.2238.

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The purpose of this investigation is to establish anti-diabetic activity relationship as well as efficiency of formulated guar gum matrix tablet using microencapsulated glibenclamide (GBLD). This research is an approach to utilize pharmaceutical excipients as an alternative hypoglycemic agent. In order to execute the objective, GBLD microspheres were formulated by emulsion solvent evaporation method using dichloromethane and methanol as solvent system which was transferred drop after drop into encapsulating medium i.e. liquid paraffin light. The formulated microspheres were exposed to various assessment parameters like drug entrapment efficiency, % yield, particle size distribution, and average particle size, the morphology of surface, dissolution study (in vitro) and micromeritics of prepared microspheres. By using these microspheres, matrix tablets were then prepared which were further evaluated for weight variation, thickness, friability, hardness, drug content, stability study, disintegration time, swelling index and dissolution (in vitro) studies were carefully carried out. Betwixt all the formulated microspheres GEM3 was found to best optimized with respect to evaluation parameters. The results obtained were found within the desired ranges where % yield 93.75%, drug entrapment efficiency 95.627% at 12th hour, and the average particle size was observed to be 179.4±0.12 µm. Then, by using the method of direct compression matrix tablets of optimized microspheres GEM3 were prepared and drug release (in vitro) was performed. The obtained results of performed parameters on matrix tableted microspheres were within the acceptable range according to IP guidelines. Out of all formulated matrix tableted microspheres, formulation GMT4 and GMT7 showed an in-vitro % drug release of 95.257 and 94.404 at 12th hour in pH 7.4 phosphate buffer.

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Dudzińska, Agnieszka, Mieczysław Żyła, and Janusz Cygankiewicz. "Influence of The Metamorphism Grade and Porosity of Hard Coal on Sorption and Desorption of Propane / Wpływ Stopnia Metamorfizmu I Porowatości Węgli Kamiennych Na Sorpcję I Desorpcję Propanu." Archives of Mining Sciences 58, no. 3 (September 1, 2013): 867–79. http://dx.doi.org/10.2478/amsc-2013-0060.

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Abstract In this paper results of investigations of sorption of hard coal samples collected from the extracted coal seams of Polish coal mines are presented. As sorbate propane was used. Examinations were carried out in the temperature of 298 K by means of volumetric assessment with the use of apparatus ASAP 2010 of Micromeritics. On the basis of conducted examinations it has been found out that the amount of sorbed propane depend on a type of coal, its metamorphism grade, content of oxygen element, moisture and porosity of these coals. The greatest amounts of propane are sorbed by low carbonized, high-porosity coals of high content of oxygen and moisture. Sorption of relatively high amounts of propane by these coals (ca. 10 cm3/g) is a result of the influence of polar surface of coals with molecules of propane and good availability of internal microporous structure of these coals for molecules of examined sorbate. Medium and high carbonized coals sorb insignificant amounts of propane. These coals have compact structure and non-polar character of their surface, their internal porous structure is to a minor degree available for propane molecules in conditions of carried out research. Sorption of propane in this case, takes place mainly in surface pores and on the surface of coals. Moreover, measurements of desorption isotherms of propane showing irreversible character of sorption were made. Desorption isotherms do not come together with sorption isotherms forming open hysteresis loop. Amounts of non-desorbing propane remaining in the coal depend on the type of examined coal.

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Prasetyo, Joni, Nurdiah Rahmawati, Galuh Wirama Murti, S. D. Sumbogo Murti, Tyas Puspitarini, Astri Pertiwi, Fusia Mirdayanti, et al. "Preliminary Study Of Local Catalyst For Low Cost Methanol Synthesis As Subsequence Process Of A Model System Of Biomass Fluidized Bed Catalytic Gasification." E3S Web of Conferences 67 (2018): 02035. http://dx.doi.org/10.1051/e3sconf/20186702035.

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Biomass waste has been emerging as an alternative energy and fuel. Direct combustion of biomass leads to harmful substances such as NOx and CO which are environmentally unfriendly manner. Innovation of clean technologies like gasification would have a potential in developing technology to reduce the emissions of harmful substances into the environment. The syngas of biomass gasification is an intermediate product which can be converted further to various types of alternative fuels especially methanol. Agency for the Assessment and application of Technology (BBPT)-Indonesia in cooperation with Gunma University-Japan has been conducting assessment and application of environmentally friendly solid biomass wastes utilization technology under the SATREPS (Science and Technology Research Partnership for Sustainable Development) program. This work is a prolongation of biomass gasification process from empty fruit bunches (EFB) to produce syngas. Furthermore, the syngas has a potential as raw material to synthesize methanol. The study of methanol synthesis focused on the development of efficient and low-cost catalyst in term of low pressure and low temperature. The catalyst of methanol synthesis was prepared by co-precipitation method with copper basis. The experiments have been performed and tested in a once-through process by Low-Pressure Fixed Bed Reactor in Micromeritics unit at a mild operating condition. The result shows that catalyst CuO: ZnO: Al2O3 (47%: 37%: 15%) has a good performance at 20 bar and 270°C with methanol concentration in the gas product up to 1.15%. On the words, the local catalyst performance comparable with commercial catalysts at low pressure and low temperature.

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SAIM, S., and B. SUBRAMANIAM. "ChemInform Abstract: Isomerization of 1-Hexene Over Pt/γ-Al2O3 Catalyst: Reaction Mixture Density and Temperature Effects on Catalyst Effectiveness Factor, Coke Laydown, and Catalyst Micromeritics." ChemInform 22, no. 52 (August 22, 2010): no. http://dx.doi.org/10.1002/chin.199152075.

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Zaman, Muhammad, Sadaf Saeed, Rabia Imtiaz Bajwa, Muhammad Shafeeq Ur Rahman, Saeed Ur Rahman, Muhammad Jamshaid, Muhammad F. Rasool, et al. "Synthesis and Evaluation of Thiol-Conjugated Poloxamer and Its Pharmaceutical Applications." Pharmaceutics 13, no. 5 (May 11, 2021): 693. http://dx.doi.org/10.3390/pharmaceutics13050693.

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The current study was designed to convert the poloxamer (PLX) into thiolated poloxamer (TPLX), followed by its physicochemical, biocompatibilities studies, and applications as a pharmaceutical excipient in the development of tacrolimus (TCM)-containing compressed tablets. Thiolation was accomplished by using thiourea as a thiol donor and hydrochloric acid (HCl) as a catalyst in the reaction. Both PLX and TPLX were evaluated for surface morphology based on SEM, the crystalline or amorphous nature of the particles, thiol contents, micromeritics, FTIR, and biocompatibility studies in albino rats. Furthermore, the polymers were used in the development of compressed tablets. Later, they were also characterized for thickness, diameter, hardness, weight variation, swelling index, disintegration time, mucoadhesion, and in vitro drug release. The outcomes of the study showed that the thiolation process was accomplished successfully, which was confirmed by FTIR, where a characteristic peak was noticed at 2695.9968 cm−1 in the FTIR scan of TPLX. Furthermore, the considerable concentration of the thiol constituents (20.625 µg/g of the polymer), which was present on the polymeric backbone, also strengthened the claim of successful thiolation. A mucoadhesion test illustrated the comparatively better mucoadhesion strength of TPLX compared to PLX. The in vitro drug release study exhibited that the TPLX-based formulation showed a more rapid (p < 0.05) release of the drug in 1 h compared to the PLX-based formulation. The in vivo toxicity studies confirmed that both PLX and TPLX were safe when they were administered to the albino rats. Conclusively, the thiolation of PLX made not only the polymer more mucoadhesive but also capable of improving the dissolution profile of TCM.

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Pinto, Joana T., Sarah Zellnitz, Tomaso Guidi, Francesca Schiaretti, Hartmuth Schroettner, and Amrit Paudel. "Spray-Congealing and Wet-Sieving as Alternative Processes for Engineering of Inhalation Carrier Particles: Comparison of Surface Properties, Blending and In Vitro Performance." Pharmaceutical Research 38, no. 6 (June 2021): 1107–23. http://dx.doi.org/10.1007/s11095-021-03061-5.

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Abstract Purpose Traditionally, α-lactose monohydrate is the carrier of choice in dry powder inhaler (DPI) formulations. Nonetheless, other sugars, such as D-mannitol, have emerged as potential alternatives. Herein, we explored different particle engineering processes to produce D-mannitol carriers for inhaled delivery. Methods Wet-sieving and spray-congealing were employed as innovative techniques to evaluate the impact of engineering on the particle properties of D-mannitol. To that end, the resulting powders were characterized concerning their solid-state, micromeritics and flowability. Afterwards, the engineered carrier particles were blended with inhalable size beclomethasone dipropionate to form low dose (1 wt%) DPI formulations. The in vitro aerosolization performance was evaluated using the NEXThaler®, a reservoir multi-dose device. Results Wet-sieving generated D-mannitol particles with a narrow particle size distribution and spray-congealing free-flowing spherical particles. The more uniform pumice particles with deep voids and clefts of wet-sieved D-mannitol (Pearl300_WS) were beneficial to drug aerosolization, only when used in combination with a ternary agent (10 wt% of ‘Preblend’). When compared to the starting material, the spray-congealed D-mannitol has shown to be promising in terms of the relative increase of the fine particle fraction of the drug (around 100%), when used without the addition of ternary agents. Conclusions The wet-sieving process and the related aerosolization performance are strongly dependent on the topography and structure of the starting material. Spray-congealing, has shown to be a potential process for generating smooth spherical particles of D-mannitol that enhance the in vitro aerosolization performance in binary blends of the carrier with a low drug dose.

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Murdjeva, Mariana A., Emilia T. Milieva, Rumen S. Stefanov, Marian M. Draganov, and Petko B. Krastev. "Experimental Investigations: Micromeritic Procedures In Assessing Antinuclear Antibody Patterns In Immunofluorescent Assay." Folia Medica 56, no. 3 (September 1, 2014): 182–86. http://dx.doi.org/10.2478/folmed-2014-0026.

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ABSTRACT AIM: The aim of this study was to introduce a micromeritic procedure (a statistical approach for small objects) in indirect immunofluorescence assay (IFA) to fi nd objective quantitative parameters of antinuclear antibody (ANA) patterns which could support a diagnosis of auto-immune diseases. MATERIALS AND METHODS: Sera of patients with systemic autoimmune diseases, McCoy-Plovdiv serum-free cell line, goat anti-human immunoglobulin-G FITC-conjugate, fluorescent microscope, computer-assisted digital image processing, analysis using a micromeritic procedure, ANOVA. RESULTS: Three ANA fluorescent patterns (homogeneous, rim and speckled) were analyzed by the micromeritic procedure. Parameters for the image brightness of the pixels (pixel grey value) were obtained and discussed as objective characteristics of fluorescent patterns: maximum ANA-linkage volume and surface density were established for the objects with speckled localization pattern. CONCLUSION: The micromeritic method for getting objective quantitative values of ANA fluorescent patterns in indirect immunofluorescent assay might be a valuable tool aiding in immunological diagnosing if integrated in a laboratory software package.

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Ertan, G., I. Sarigüllü, and T. Guneri. "Micromeritic Properties of Nitrofurantoin Microcapsules." Drug Development and Industrial Pharmacy 21, no. 11 (January 1995): 1323–28. http://dx.doi.org/10.3109/03639049509063020.

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OZYAZICI, M. "Micromeritic studies on nicardipine hydrochloride microcapsules." International Journal of Pharmaceutics 138, no. 1 (July 1996): 25–35. http://dx.doi.org/10.1016/0378-5173(96)04516-4.

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Islam, Md Sazzadul, and Md Saiful Islam Pathan. "Improving Micromeritic Properties of Ibuprofen: An Agglomeration Approach." Bangladesh Pharmaceutical Journal 20, no. 1 (April 5, 2017): 90–98. http://dx.doi.org/10.3329/bpj.v20i1.32098.

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Ibuprofen is one of the common NSAIDs having poor water solubility, low dissolution, weak flow properties and reduced compressibility. These downsides of ibuprofen crystal upraise crucial challenges during development of a dosage form. The aim of this present work was to modify the physical form of ibuprofen by changing micromeritic properties. Seven different formulations of ibuprofen agglomerates such as F-1, F-2, F-3, F-4, F-5, F-6 and F-7 were prepared to convert the needle shaped ibuprofen crystals into agglomerates so that the desired micromeritic properties can be achieved. In this study, agglomerates of ibuprofen were prepared by Quasi emulsion solvent diffusion (QESD) method in association with two surfactants (sodium lauryl sulphateand Tween 80) at three different concentrations for each. The micromeritic properties of the prepared agglomerates were evaluated for bulk density, tapped density, Carrs index, Hausners ratio, angle of repose along with the release behavior of agglomerates. From dissolution study, it was observed that the release of drug was directly proportional to the surfactant concentration. Here, it was also revealed that there was no interaction among ibuprofen and other excipients as evident from DSC and FTIR studies.Bangladesh Pharmaceutical Journal 20(1): 90-98, 2017

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Saikia, Trideep, Jonab Ali, and Biswajit Das. "ISOLATION AND CHARECTERIZATION OF TAMARIND SEED POLYSACCHARIDES–A NATURAL RELEASE RETARDANT." International Journal of Current Pharmaceutical Research 9, no. 4 (July 14, 2017): 114. http://dx.doi.org/10.22159/ijcpr.2017v9i4.20972.

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Objective: The main objective was to isolate and characterise a naturally obtain polysaccharides which have the property to formulate sustain release product.Methods: Tamarind Seed Polysaccharides (TSP) was isolated from seed of Tamarindus indica by crushed the seed into powder and boiled with water at 45 °C to extract the polysaccharides. After boiling for 12 h the supernatant liquids were collected and stored in cool place. After the liquids become cooled acetone was added and freeze at-40 °C. Freeze materials then lyophilized to extract out the Tamarind seed polysaccharides. After that polysaccharide was evaluated for organoleptic, micromeritic and other characterization parameter along with microbial contaminationResults: Yield of polysaccharides was found to be 16.85%. As per the micromeritic property flow of polysaccharides, tapped and bulk density was found in acceptable range. Microbial studies confirmed that TSP doesn’t support microbial growth.Conclusion: The polysaccharides were isolated, extracted and characterized. The characterization was carried out for different physiochemical properties and powder properties.

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Saritha, Damineni, Penjuri Subhash Chandra Bose, Poreddy Srikanth Reddy, Grandhi Madhuri, and Ravouru Nagaraju. "Improved dissolution and micromeritic properties of naproxen from spherical agglomerates: preparation, in vitro and in vivo characterization." Brazilian Journal of Pharmaceutical Sciences 48, no. 4 (December 2012): 667–76. http://dx.doi.org/10.1590/s1984-82502012000400010.

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Naproxen, an anti-inflammatory drug, exhibits poor aqueous solubility, which limits the pharmacological effects. The present work was carried out to study the effect of agglomeration on micromeritic properties and dissolution. Naproxen agglomerates were prepared by using a three solvents system composed of acetone (good solvent), water (non-solvent) and dichloromethane (bridging liquid). Differential Scanning Calorimetry (DSC) results showed no change in the drug after crystallization process. X-Ray Powder Diffraction (XRPD) studies showed the sharp peaks are present in the diffractograms of spherical agglomerates with minor reduction in height of the peaks. The residual solvents are largely below the tolerated limits in the agglomerates. Scanning Electronic Microscopy (SEM) studies showed that agglomerates were spherical in structure and formed by cluster of small crystals. The agglomerates exhibited improved solubility, dissolution rate and micromeritic properties compared to pure drug. Anti-inflammatory studies were conducted in Wistar strain male albino rats and naproxen agglomerates showed more significant activity than the pure drug.

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Nikolakakis, I., K. Kachrimanis, and S. Malamataris. "Relations between crystallisation conditions and micromeritic properties of ibuprofen." International Journal of Pharmaceutics 201, no. 1 (May 2000): 79–88. http://dx.doi.org/10.1016/s0378-5173(00)00398-7.

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Gupta, Venkadari, Srinivas Mutalik, Madhobhai Patel, and Girish Jani. "Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties." Acta Pharmaceutica 57, no. 2 (June 1, 2007): 173–84. http://dx.doi.org/10.2478/v10007-007-0014-8.

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Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic propertiesCelecoxib spherical agglomerates were prepared with polyvinylpyrrolidone (PVP) using acetone, water and chloroform as solvent, non-solvent and bridging liquid, respectively. The agglomerates were characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), IR spectroscopic studies and scanning electron microscopy (SEM). The IR spectroscopy and DSC results indicated the absence of any interactions between drug and additives. XRD studies showed a decrease in crystallinity in agglomerates. The crystals exhibited significantly improved micromeritic properties compared to pure drug. The loading efficiency (% or mg drug per 100 mg crystals) was in the range of 93.9 ± 2.3 and 97.3 ± 1.3% (n = 3) with all formulations. The aqueous solubility and dissolution rate of the drug from crystals was significantly (p < 0.05) increased (nearly two times). The solubility andin vitrodrug release rates increased with an increase in PVP concentration (from 2.5 to 10%). The SEM studies showed that the crystal posseses a good spherical shape with smooth and regular surface.

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Таmarkina, Ju V., I. B. Frolova, O. O. Velichko, and V. O. Кucherenko. "ADSORPTION OF PHENOL COMPOUNDS BY ACTIVATED CARBON FORMED DURING CARBONIZATION OF BROWN COAL WITH POTASSIUM HYDROXIDE." Journal of Coal Chemistry 2 (2021): 21–32. http://dx.doi.org/10.31081/1681-309x-2021-0-2-21-32.

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The aim of the work is to evaluate the adsorption capacity of activated carbons (ACs) from brown coal in relation to phenol (Ph) and 4-chlorophenol (CPh) and the influence of the AСs formation temperature under carbonization with potassium hydroxide on capacities. The samples of ACs were prepared by heating with KOH (1 g/g, 1 h) at a given temperature in the range of t=400-800°C and marked as AC(t). The ACs porosity characteristics were determined by low-temperature (77 K) adsorption – desorption nitrogen isotherms (Micromeritics ASAP 2020) calculated by the 2D-NLDFT method. They are as follows: total pore volume Vt (cm3 /g), specific surface area S (m2 /g), volume (Vmi) and surface (Smi) of micropores, volume (V1nm) and surface (S1nm) of subnanopores, the total surface of meso- and macropores Sme+ma. The adsorption of phenol and 4-chlorophenol was determined at equilibrium concentrations in aqueous solutions ≤5 mmol/l (25 °C). The alkaline carbonization temperature of brown coal was found to be a key factor in the formation of micro- and subnanopores, the growth of the AC specific surface area (from 12.8 m2 /g to 1142 m2 /g) and adsorption activity against phenolic compounds. Its increase to 800°C causes an exponential increase in the AC adsorption capacity in 8.7 times (Ph) and 6.7 times (CPh), which is proportional to the concentration of surface adsorption centers (AdCs). The values of the effective activation energy of forming AdCs being active in relation to adsorbates were determined as 29.5 kJ/mol (Ph) and 31.5 kJ/mol (CPh). The kinetics of Ph and CPh absorption was found to obey the pseudosecond-order model, and the adsorption rate is limited by the interaction of the adsorbate molecules with the AdCs. Adsorption isotherms at equilibrium concentrations ≤ 5 mmol/l are approximated by the Langmuir model (R2 ≥ 0.994). Compared with Ph, the degree of CPh extraction is much higher, which is a consequence of its stronger connection with the AC surface. The specific adsorption capacity for Ph and CPh shows a sharp decrease (10-16 times) with increasing carbonization temperature from 400° C to 550 °C and a weak temperature dependence at 550-800 °C. In this range, ACs are formed with similar concentrations of AdCs, but different for various phenolic compounds. Adsorption on brown coal ACs was postulated to include π-π interaction, formation of electron-donor-acceptor complexes and formation of hydrogen bonds, but their contributions depend on adsorbate nature and they change while increasing alkaline carbonization temperature. Keywords: brown coal, alkaline carbonization, activated carbon, porosity, adsorption, phenol, 4-chlorophenol. Corresponding author Таmarkina Ju.V., e-mail: Tamarkina@nas.gov.ua

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Nath, Shelli, and Yashwant V. Pathak. "Evaluation of maltodextrins as tablet excipients I. Micromeritic and compressional characterization." Powder Technology 75, no. 1 (April 1993): 97–101. http://dx.doi.org/10.1016/0032-5910(93)80029-a.

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Sowa, Michał, Anneke R. Klapwijk, Michael Ostendorf, and Wolfgang Beckmann. "Particle Engineering of an Active Pharmaceutical Ingredient for Improved Micromeritic Properties." Chemical Engineering & Technology 40, no. 7 (June 9, 2017): 1282–92. http://dx.doi.org/10.1002/ceat.201600663.

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Patil, Ashwini, Yogesh Pore, Yogesh Gavhane, Shitalkumar Patil, and Sachinkumar Patil. "Spherical crystallization of ezetimibe for improvement in physicochemical and micromeritic properties." Journal of Pharmaceutical Investigation 44, no. 3 (February 14, 2014): 213–24. http://dx.doi.org/10.1007/s40005-014-0117-4.

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Badhana, Seema, Navneet Garud, and Akanksha Garud. "Colon specific drug delivery of mesalamine using eudragit S100-coated chitosan microspheres for the treatment of ulcerative colitis." International Current Pharmaceutical Journal 2, no. 3 (February 2, 2013): 42–48. http://dx.doi.org/10.3329/icpj.v2i3.13577.

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The purpose of the present study was to prepare, characterize and evaluate the colon-targeted microspheres of mesalamine for the treatment and management of ulcerative colitis (UC). Microspheres were prepared by the ionic-gelation emulsification method using tripolyphosphate (TPP) as cross linking agent. The microspheres were coated with Eudragit S-100 by the solvent evaporation technique to prevent drug release in the stomach. The prepared microspheres were evaluated for surface morphology, entrapment efficiency, drug loading, micromeritic properties and in-vitro drug release. The microspheres formed had rough surface as observed in scanning electron microscopy. The entrapment efficiency of microspheres ranged from 43.72%-82.27%, drug loading from 20.28%-33.26%. The size of the prepared microspheres ranged between 61.22-90.41µm which was found to increase with increase in polymer concentration. All values are statistically significant as p<0.05. Micromeritic properties showed good flow properties and packability of prepared microspheres. The drug release of mesalamine from microspheres was found to decrease as the polymer concentration increases. The release profile of mesalamine from eudragit-coated chitosan microspheres was found to be pH dependent. It was observed that Eudragit S100 coated chitosan microspheres gave no release in the simulated gastric fluid, negligible release in the simulated intestinal fluid and maximum release in the colonic environment. It was concluded from the study that Eudragit-coated chitosan microspheres were promising carriers for colon-targeted delivery of Mesalamine.DOI: http://dx.doi.org/10.3329/icpj.v2i3.13577 International Current Pharmaceutical Journal, February 2013, 2(3): 42-48

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Manivannan, Subramanian, Akshay M, Bhuvaneswari S, and Nify F. "FORMULATION AND EVALUATION OF GASTRORETENTIVE MICROBALLOONS OF ACEBROPHYLLINE FOR THE TREATMENT OF BRONCHIAL ASTHMA." Asian Journal of Pharmaceutical and Clinical Research 9, no. 5 (September 1, 2016): 105. http://dx.doi.org/10.22159/ajpcr.2016.v9i5.12603.

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ABSTRACTObjective: Gastroretentive dosage forms are an approach for prolonged and predictable drug delivery in the upper gastrointestinal tract to controlthe gastric residence time. Microballoons are considered as one of the most promising buoyant drug delivery systems as they possess the advantagesof both multiple-unit systems and good floating properties. Acebrophylline is a xanthine derivative with potent bronchodilator, mucosecretolytic, andanti-inflammatory property. It is used to treat bronchial asthma and chronic obstructive pulmonary diseases.Methods: Microballoons of acebrophylline were prepared by emulsion solvent diffusion method using hydroxypropyl methylcellulose (HPMC) andethyl cellulose (EC) as polymer. The microballoons were evaluated with their micromeritic properties, particle size, tapped density, compressibilityindex, angle of repose, percentage yield, in vitro buoyancy, entrapment efficiency, drug-polymer compatibility, scanning electron microscopy (SEM),and drug release kinetics.Results: The mean particle size of the microballoons formulation MB1 to MB6 containing HPMC and EC was in the range between 226±16 and 577±10,respectively. The mean particle size of microballoons was found to increase with increasing polymer concentration. The micromeritic properties werefound be good, and SEM confirmed their hollow structure with smooth and dense which helped to prolong floating to increase residence time instomach. The in vitro drug release studies showed controlled release of acebrophylline microballoons in the simulated gastric fluid more than 12 hrs.Conclusions: The results showed that the prepared floating microballoons of acebrophylline prove to be potential multiple-unit delivery devicesadaptable for safe and effective sustained drug delivery.Keywords: Microballoons, Acebrophylline, Bronchial asthma, Hydroxypropyl methylcellulose, Ethyl cellulose.

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Prabakaran, L., and Meenakshi Bajpai. "Novel Micropelletization Technique: Highly Improved Dissolution, Wettability and Micromeritic Behavior of Domperidone." Current Drug Delivery 3, no. 3 (July 1, 2006): 307–13. http://dx.doi.org/10.2174/156720106777731046.

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Chime, SalomeA, EC Umeyor, VI Onyishi, GC Onunkwo, and AA Attama. "Analgesic and micromeritic evaluations of SRMS-based oral lipospheres of diclofenac potassium." Indian Journal of Pharmaceutical Sciences 75, no. 3 (2013): 302. http://dx.doi.org/10.4103/0250-474x.117436.

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Zhang, Peiqi, Shanshan Tie, Mengpei Liu, and Wei Zong. "Effects of superfine grinding on micromeritic properties of Eucommia ulmoides Oliv. leaves." Bangladesh Journal of Botany 49, no. 4 (December 31, 2020): 1037–44. http://dx.doi.org/10.3329/bjb.v49i4.52536.

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Effects of regular grinding and superfine grinding on the micromeritic properties of Eucommia ulmoides leaves were investigated. Coarse powder 1 (5732 nm), 2 (4784.67 nm), 3 (4133.67 nm), 4 (2119 nm) were prepared by regular grinding. Superfine powder 5 (1310.67 nm) was prepared by superfine grinding, all the particle sizes presented normal distribution. Results showed that Eucommia ulmoides leaf powders have smaller size, greater bulk density and smaller angle of repose. The water solubility index values, water holding capacity value and oil binding capacity value were significantly improved as the size decreases. Furthermore, biological microscopy revealed the surface morphology of five powders. FT-IR analysis showed the nature of Eucommia ulmoides leaves unchanged. These results showed that the physicochemical and functional properties of Eucommia ulmoides leaves can be improved by superfine grinding, which would be more suitable for the development of functional compounds than native Eucommia ulmoides leaves.

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Gupta, V. Rama Mohan, Srikanth K, Sree Giri Prasad, B, G. Naveen Kumar Reddy, and Sudheer B. "Formulation and Evaluation of Directly Compressible Agglomerates of Celecoxib." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 4 (February 28, 2011): 1193–204. http://dx.doi.org/10.37285/ijpsn.2010.3.4.4.

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Prepared spherical crystals of Celecoxib to increase the compressible properties, dissolution rate and bioavailability, using hydrophilic polymers such as PEG-4000, sod.CMC, sod.alginate and PVP K-30. All the formulations were characterized for micromeritic properties, Drug loading, solubility, in vitro drug release and mean dissolutiom time (MDT). New formulations showed higher dissolution rates and less MDT values than the pure celecoxib. Among all, the crystals prepared with 10 % w/v PVP K-30 exhibited maximum dissolution rate (2.95±0.23%) and very less MDT values (18.50 ± 4.01 min). Hence it was considered as optimized formulation.

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Journal articles on the topic 'Micromeritics'

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