Relevant bibliographies by topics / Micromeritics

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Academic literature on the topic 'Micromeritics'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Micromeritics"

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Himawan, A., N. J. N. Djide, M. Mudjahid, A. D. I. Lukita, A. Arjuna, and Aliyah. "Physicochemical and Micromeritics Properties of Ketoprofen-Tartaric Acid Binary System." Journal of Physics: Conference Series 1341 (October 2019): 072004. http://dx.doi.org/10.1088/1742-6596/1341/7/072004.

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Paramakrishnan, N., S. Jha, and K. Jayaram Kumar. "Effect of carboxymethylation on physicochemical, micromeritics and release characteristics of Kyllinga nemoralis starch." International Journal of Biological Macromolecules 92 (November 2016): 543–49. http://dx.doi.org/10.1016/j.ijbiomac.2016.07.039.

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Kedia, Kishori, and Sarika Wairkar. "Improved micromeritics, packing properties and compressibility of high dose drug, Cycloserine, by spherical crystallization." Powder Technology 344 (February 2019): 665–72. http://dx.doi.org/10.1016/j.powtec.2018.12.068.

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Ayon, Navid Jubaer, Ikramul Hasan, Md Shfiqul Islam, and Md Selim Reza. "Preparation and characterization of Gliclazide incorporated Cellulosic Microspheres: studies on drug release, compatibility and micromeritics." Dhaka University Journal of Pharmaceutical Sciences 13, no. 2 (February 5, 2015): 149–66. http://dx.doi.org/10.3329/dujps.v13i2.21893.

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Polymeric microspheres of gliclazide were prepared to provide sustained release delivery of gliclazide to aid in continuous therapy with high margin of safety. Gliclazide was microencapsulated with different polymers namely HPMC K100LV, Ethocel (20 cps) and HPMC K100M by emulsion solvent evaporation technique using acetone as internal phase and liquid paraffin as external phase. Seventeen formulations were prepared using different drug loading and polymeric ratio of which nine formulations were prepared by a 32 full factorial design. Each formulation was evaluated for flow properties, particle size, surface morphology, drug entrapment efficiency, drug release and compatibility. Yield (%) for every batch of microspheres was measured. Flow properties of the microspheres were examined by determining bulk density, tapped density, Carr’s compressibility index, Hausner ratio and angle of repose. Particle size distribution was examined by sieving and particle size analyzer. Surface morphology was determined by scanning electron microscopy (SEM). In-vitro drug release was studied in a paddle type dissolution apparatus (USP Type II Dissolution Apparatus) for a period of 8 hours at 37°C using phosphate buffer ( pH 7.4). FTIR and DSC studies established compatibility of the drug with the polymers. Microspheres prepared with Ethocel (20 cps) and HPMC K100M were free flowing than those prepared only with HPMC K100LV. Entrapment efficiencies were within 75.88-99.69%. Microspheres prepared with Ethocel (20 cps) and HPMC K100M showed more sustained release when compared to microspheres prepared with HPMC K100LV only. Increase in drug loading resulted in increased drug release for the microspheres. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism ranging from diffusion controlled to anomalous type. Ethocel and HPMC K100M in a ratio of 1:3 exhibited better sustained release properties than 1:1 and 3:1 ratios. The release rate of gliclazide from microspheres prepared with Ethocel (20 cps) and HPMC K100M was less than the release rate of gliclazide from microspheres prepared with HPMC K100LV, demonstrating Ethocel and HPMC K100M as suitable polymeric blend for preparing the controlled release formulation for gliclazide whereas, HPMC K100LV was found not suitable candidate when used alone as a polymer. DOI: http://dx.doi.org/10.3329/dujps.v13i2.21893 Dhaka Univ. J. Pharm. Sci. 13(2): 149-166, 2014 (December)
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Viswanathan, Chelakara L., Sushrut K. Kulkarni, and Dhanashri R. Kolwankar. "Spherical agglomeration of mefenamic acid and nabumetone to improve micromeritics and solubility: A technical note." AAPS PharmSciTech 7, no. 2 (June 2006): E122—E125. http://dx.doi.org/10.1208/pt070248.

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Ma, Cheng, Wenhao Wang, Zhengwei Huang, Xiaona Chen, Weifen Ye, Kewei Pan, Ruhua Ma, et al. "Effect of the cargo lipophilicity on powder micromeritics properties of drug-loaded solid lipid microparticles." Journal of Drug Delivery Science and Technology 51 (June 2019): 614–20. http://dx.doi.org/10.1016/j.jddst.2019.03.025.

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Pryszcz, Adrian, Barbora Grycová, Ivan Koutník, and Veronika Blahůšková. "Characterization of Tar Deposits, Extraction and Sorption Properties." GeoScience Engineering 62, no. 2 (June 1, 2016): 1–4. http://dx.doi.org/10.1515/gse-2016-0010.

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Abstract The main goal of this paper was to characterize and find a useful solution for the decomposition of tar deposits. For the experimental part, tar deposits, formed by polymerization and condensation reactions, were chosen from a storage tank for tars. At first the initial analyses of tar deposits (elemental, thermogravimetric, and calorimetric analyses) were performed. After the characterization, the tar deposits were extracted in the Soxhlet extractor by acetone, toluene, and quinolone and activated with potassium hydroxide. As the final step of this work, the sorption characterization on the 3Flex Surface Characterization Analyzer (Micromeritics) was performed. The specific surface area of the samples was evaluated using two methods - a single point measurement at p/p0=0.2 and BET method. Micropore and external surface areas were calculated based on a t-plot analysis (carbon black model).
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RILEY, C., S. ADEBAYO, A. WHEATLEY, and H. ASEMOTA. "The interplay between yam (Dioscorea sp.) starch botanical source, micromeritics and functionality in paracetamol granules for reconstitution." European Journal of Pharmaceutics and Biopharmaceutics 70, no. 1 (September 2008): 326–34. http://dx.doi.org/10.1016/j.ejpb.2008.03.001.

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Kaur, Harjeet, Baldeep Kumar, Amitava Chakrabarti, Bikash Medhi, Manish Modi, Bishan Dass Radotra, Ritu Aggarwal, and Vivek Ranjan Sinha. "A New Therapeutic Approach for Brain Delivery of Epigallocatechin Gallate: Development and Characterization Studies." Current Drug Delivery 16, no. 1 (November 27, 2018): 59–65. http://dx.doi.org/10.2174/1567201815666180926121104.

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Background: Blood-brain permeability is the primary concern when dealing with the biodistribution of drugs to the brain in neurological diseases. Objective: The purpose of the study is to develop the nanoformulation of Epigallocatechin gallate (EGCG) in order to improve its bioavailability and penetration into the brain. Methods: EGCG loaded Solid Lipid Nanoparticles (SLNs) have been developed using microemulsification method and pharmacological assessments were performed. Results: Surface morphology and micromeritics analysis showed the successful development of EGCG loaded solid lipid nanoparticles with an average size of 162.4 nm and spherical in shape. In vitro release studies indicated a consistent and slow drug release. Pharmacological evaluation of SLN-EGCG demonstrated a significant improvement in cerebral ischemia-induced memory impairment. Conclusion: The results indicate that the EGCG loaded SLNs provide a potential drug delivery system for improved delivery of EGCG to the brain, hence, enhancing its brain bioavailability.
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Rashad, Amira A., Sara Nageeb El-Helaly, Randa T. Abd El Rehim, and Omaima N. El-Gazayerly. "Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strength." Acta Pharmaceutica 69, no. 3 (September 1, 2019): 381–98. http://dx.doi.org/10.2478/acph-2019-0022.

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Abstract Reduced bioavailability of azelnidipine is related to its poor aqueous solubility and extensive first-pass metabolism, which hinder its efficacy. These problems were addressed by implementing (1) a liquisol technique for promoting the dissolution rate in a controlled-release manner and (2) a core-in-cup bucco-adhesive drug delivery system as an alternative to the oral route. A 33 factorial design was used to study the effects of polymer type (sodium carboxymethyl cellulose (CMC Na), chitosan, or Carbomer P940) concentration (5, 10 or 15 %) and preparation technique (simple mix, liquisol or wet granulation) on the dissolution and mucoadhesion of core-in-cup azelnidipine buccoadhesive tablets. Tablet micromeritics, swelling index, mucoadhesive strength and in vitro release were characterized. Statistical analyses of these factors show ed significant effects on the studied responses, where F#16 prepared by the liquisol technique and containing 15 % CMC Na was chosen with an overall desirability of 0.953.
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Dissertations / Theses on the topic "Micromeritics"

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Lamolha, Marco Aurélio. "Desenvolvimento e avaliação biofarmacêutica \"in vitro\" de comprimidos de liberação convencional contendo hidroclorotiazida 50mg." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-10022009-233838/.

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No presente trabalho, foram desenvolvidos e avaliados comprimidos de liberação convencional de hidroclorotiazida 50mg: 6 por granulação úmida e 8 por compressão direta. Na etapa de pré-formulação, foram realizados estudos termoanalíticos (TG/DTG e DSC) para seleção de excipientes compatíveis com o fármaco e estudos micromeríticos para avaliação das propriedades de fluxo e compressibilidade das matérias-primas empregadas, dos granulados e das misturas para compressão direta obtidos. As formulações foram avaliadas quanto ao diâmetro, espessura, dureza, friabilidade, desintegração, dissolução, teor, uniformidade de conteúdo, perfil e eficiência de dissolução, empregando-se métodos analíticos devidamente validados. As melhores formulações obtidas por granulação úmida (formulação B1) e compressão direta (formulação J) foram comparadas com o produto referência para comprimidos de hidroclorotiazida, quanto à eficiência de dissolução e demonstraram ser estatisticamente semelhantes entre si e superiores ao produto referência, nas condições empregadas.
In this work, conventional liberation of hydrochlorothiazide 50 mg: 6 for wet granulation and 8 for direct compression - were developed and valuated. In the pre-formulation stage, thermoanalytical studies (TG/DTC and DSC) were realized to select compatible excipients with the drug; as well as micromeritical studies were realized to value the flow and compressibility properties of the used raw materials, granulates and obtained mixtures for direct compression. The prescriptions were valuated in relation to diameter, thickness, hardness, friability, disintegration, dissolution, assay, uniformity of contents, profile and efficiency of dissolution, using analytical methods property validated. The best formulations obtained by wet granulation (B1 formulation) and direct compression (J formulation) were compared with the reference product to tablet of hydrochlorothiazide, concerning to the efficiency of dissolution and they demonstrated to be statistically similar to each other and to be superior to the reference product, in the used conditions.
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Paluch, Krzysztof J., L. Tajber, O. I. Corrigan, and A. M. Healy. "Impact of alternative solid state forms and specific surface area of high-dose, hydrophilic active pharmaceutical ingredients on tabletability." 2013. http://hdl.handle.net/10454/14342.

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Yes
In order to investigate the effect of using different solid state forms and specific surface area (TBET) of active pharmaceutical ingredients on tabletability and dissolution performance, the mono- and dihydrated crystalline forms of chlorothiazide sodium and chlorothiazide potassium (CTZK) salts were compared to alternative anhydrous and amorphous forms, as well as to amorphous microparticles of chlorothiazide sodium and potassium which were produced by spray drying and had a large specific surface area. The tablet hardness and tensile strength, porosity, and specific surface area of single-component, convex tablets prepared at different compression pressures were characterized. Results confirmed the complexity of the compressibility mechanisms. In general it may be concluded that factors such as solid-state form (crystalline vs amorphous), type of hydration (presence of interstitial molecules of water, dehydrates), or specific surface area of the material have a direct impact on the tabletability of the powder. It was observed that, for powders of the same solid state form, those with a larger specific surface area compacted well, and better than powders of a lower surface area, even at relatively low compression pressures. Compacts prepared at lower compression pressures from high surface area porous microparticles presented the shortest times to dissolve, when compared with compacts made of equivalent materials, which had to be compressed at higher compression pressures in order to obtain satisfactory compacts. Therefore, materials composed of nanoparticulate microparticles (NPMPs) may be considered as suitable for direct compaction and possibly for inclusion in tablet formulations as bulking agents, APIs, carriers, or binders due to their good compactibility performance
Solid State Pharmaceutical Cluster (SSPC), supported by Science Foundation Ireland under Grant No. 07/SRC/B1158.
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Lin, Chih Cheng, and 林志誠. "Improvement of the Micromeritic Characteristics and the Dissolution Rate of Drug Crystals by the Spherical Crystallization Technique." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/69458328931997569402.

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碩士
國立臺北科技大學
化學工程系碩士班
91
Crystallization is a significant separation technique which is often used in pharmaceutical industry. This method not only isolates drug substances with high purity directly from the solution, but improves the micromeritic characteristics and the quality of the drug products. Many of the drug substances are poorly soluble in water or gastrointestinal fluids. Considerable attention is therefore placed to reduce the particle size by milling steps to enhance the bioavailability. However, the fine crystals with poor flowability, packability and compressibility may result in lowering the efficiency of manufacturing processes. Moreover, the additional milling steps facilitate the drugs being polluted, affecting the purity and bioavailability of the products. The aim of this study is to improve the micromeritic characteristics and the dissolution rate by spherical crystallization technique, so that the manufacturing processes are simplified and the bioavailability therefore is enhanced. The effects of various operating parameters on spherically agglomerated crystals such as the concentration of water-soluble polymers, the temperature difference（ΔT）between the drug solution and the aqueous solution, the rate of agitation, the volume ratio of drug solution and aqueous solution, the concentration of drug solution and the titration rate are extensively studied. In addition, the water-soluble polymers are incorporated into the spherically agglomerated crystals which may provide greater wettability and permeability of the drugs. On the experiment of micromeritic properties, it shows the good packability and flowability for spherical crystals due to the spherical shape and smooth surface. The porous structure of spherical agglomerated crystals also has a large specific surface area so as to increase the dissolution rate of the drug. Furthermore, the dissolution kinetics of drug substances produced from the spherical crystallization were carried out. It is validated that the spherical crystallization can effectively provides a better dissolution rate of the products.
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Paluch, Krzysztof J., L. Tajber, M. I. Amaro, O. I. Corrigan, and A. M. Healy. "Impact of process variables on the micromeritic and physicochemical properties of spray-dried microparticles, part II: physicochemical characterisation of spray-dried materials." 2012. http://hdl.handle.net/10454/14361.

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Objectives  In this work we investigated the residual organic solvent content and physicochemical properties of spray-dried chlorothiazide sodium (CTZNa) and potassium (CTZK) salts. Methods  The powders were characterised by thermal, X-ray diffraction, infrared and dynamic vapour sorption (DVS) analyses. Solvent levels were investigated by Karl–Fischer titration and gas chromatography. Key findings  Spray-drying from water, methanol (MeOH) and mixes of MeOH and butyl acetate (BA) resulted in amorphous microparticles. The glass transition temperatures of CTZNa and CTZK were ∼192 and ∼159°C, respectively. These materials retained their amorphous nature when stored at 25°C in dry conditions for at least 6 months with no chemical decomposition observed. DVS determined the critical relative humidity of recrystallisation of CTZNa and CTZK to be 57% RH and 58% RH, respectively. The inlet temperature dependant oxidation of MeOH to formaldehyde was observed; the formaldehyde was seen to deposit within the amorphous matrix of spray-dried product. Spray-drying in the open blowing mode coupled with secondary drying resulted in a three-fold reduction in residual BA (below pharmacopoeial permitted daily exposure limit) compared to spray-drying in the closed mode. Conclusions  Experiments showed that recirculation of recovered drying gas increases the risk of deposition of residual solvents in the spray-dried product.
The Irish Research Council for Science and Engineering Technology (IRCSET), the Solid State Pharmaceutical Cluster (SSPC), supported by Science Foundation Ireland under grant number (07/SRC/B1158) and the Irish Drug Delivery Research Network, a Strategic Research Cluster grant (07/SRC/B1154) under the National Development Plan co-funded by EU Structural Funds and Science Foundation Ireland.
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Paluch, Krzysztof J., L. Tajber, O. I. Corrigan, and A. M. Healy. "Impact of process variables on the micromeritic and physicochemical properties of spray-dried porous microparticles, part I: introduction of a new morphology classification system." 2012. http://hdl.handle.net/10454/14360.

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Objectives This work investigated the impact of spray drying variables such as feedconcentration, solvent composition and the drying mode, on the micromeriticproperties of chlorothiazide sodium (CTZNa) and chlorothiazide potassium(CTZK).Methods Microparticles were prepared by spray drying and characterised usingthermal analysis, helium pycnometry, laser diffraction, specific surface area analysisand scanning electron microscopy.Key findings Microparticles produced under different process conditions pre-sented several types of morphology.To systematise the description of morphology ofmicroparticles, a novel morphology classification system was introduced. The shapeof the microparticles was described as spherical (1) or irregular (2) and the surfacewas classified as smooth (A) or crumpled (B). Three classes of morphology of micro-particles were discerned visually: class I, non-porous; classes II and III, comprisingdiffering types of porosity characteristics. The interior was categorised as solid/continuous (a), hollow (b), unknown (g) and hollow with microparticulate content(d). Nanoporous microparticles of CTZNa and CTZK, produced without recircula-tion of the drying gas, had the largest specific surface area of 72.3 and 90.2 m2/g,respectively, and presented morphology of class 1BIIIa.Conclusions Alteration of spray drying process variables, particularly solvent com-position and feed concentration can have a significant effect on the morphology ofspray dried microparticulate products. Morphology of spray dried particles may beusefully described using the morphology classification system.
The Irish Research Council for Science and Engineering Technology (IRCSET), the Solid State Pharmaceutical Cluster (SSPC), supported by Science Foundation Ireland under grant number [07/SRC/B1158] and the Irish Drug Delivery Research Network, a Strategic Research Cluster grant (07/SRC/B1154) under the National Development Plan co-funded by EU Structural Funds and Science Foundation Ireland.
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Book chapters on the topic "Micromeritics"

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Kalita, Pratap, Abdul Baquee Ahmed, Abhinab Goswami, Saikat Sen, and Raja Chakraborty. "Physicochemical, Micromeritics, Biomedical, and Pharmaceutical Applications of Assam Bora Rice Starch." In Evidence Based Validation of Traditional Medicines, 817–28. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8127-4_39.

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Newman, Ann. "Micromeritics." In Physical Characterization of Pharmaceutical Solids, 253–80. CRC Press, 1995. http://dx.doi.org/10.1201/b14204-10.

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"Micromeritics." In Advanced Pharmaceutical Solids, 78–105. CRC Press, 2000. http://dx.doi.org/10.1201/b16941-4.

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Jambhekar, Sunil. "Micromeritics and Rheology." In Theory and Practice of Contemporary Pharmaceutics, 137–61. CRC Press, 2004. http://dx.doi.org/10.1201/9780203644478.ch5.

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Jambhekar, Sunil S. "Micromeritics and Rheology." In Theory and Practice of Contemporary Pharmaceutics, 137–61. CRC Press, 2021. http://dx.doi.org/10.1201/9780203644478-6.

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Maheshwari, Rahul, Pooja Todke, Kaushik Kuche, Nidhi Raval, and Rakesh K. Tekade. "Micromeritics in Pharmaceutical Product Development." In Dosage Form Design Considerations, 599–635. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-814423-7.00017-4.

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"micromeritic." In Dictionary Geotechnical Engineering/Wörterbuch GeoTechnik, 866. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-41714-6_131611.

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