Relevant bibliographies by topics / Microfluidics and nanofluidics

Academic literature on the topic 'Microfluidics and nanofluidics'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Microfluidics and nanofluidics"

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Yang, Ruey-Jen. "Microfluidics and Nanofluidics." Inventions 4, no. 1 (February 11, 2019): 12. http://dx.doi.org/10.3390/inventions4010012.

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Prakash, Shaurya, Marie Pinti, and Bharat Bhushan. "Theory, fabrication and applications of microfluidic and nanofluidic biosensors." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 370, no. 1967 (May 28, 2012): 2269–303. http://dx.doi.org/10.1098/rsta.2011.0498.

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Biosensors are a broad array of devices that detect the type and amount of a biological species or biomolecule. Several different types of biosensors have been developed that rely on changes to mechanical, chemical or electrical properties of the transduction or sensing element to induce a measurable signal. Often, a biosensor will integrate several functions or unit operations such as sample extraction, manipulation and detection on a single platform. This review begins with an overview of the current state-of-the-art biosensor field. Next, the review delves into a special class of biosensors that rely on microfluidics and nanofluidics by presenting the underlying theory, fabrication and several examples and applications of microfluidic and nanofluidic sensors.
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Tiwari, Ashutosh. "Microfluidics And Nanofluidics Conference Series." Advanced Materials Letters 8, no. 7 (July 1, 2017): 752–53. http://dx.doi.org/10.5185/amlett.2017/7001.

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Yeo, Leslie, Hsueh-Chia Chang, and Weijia Wen. "Advances in Microfluidics and Nanofluidics." Applied Rheology 19, no. 3 (June 1, 2009): 175–76. http://dx.doi.org/10.1515/arh-2009-0023.

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Sahadevan, Vignesh, Bivas Panigrahi, and Chia-Yuan Chen. "Microfluidic Applications of Artificial Cilia: Recent Progress, Demonstration, and Future Perspectives." Micromachines 13, no. 5 (May 3, 2022): 735. http://dx.doi.org/10.3390/mi13050735.

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Artificial cilia-based microfluidics is a promising alternative in lab-on-a-chip applications which provides an efficient way to manipulate fluid flow in a microfluidic environment with high precision. Additionally, it can induce favorable local flows toward practical biomedical applications. The endowment of artificial cilia with their anatomy and capabilities such as mixing, pumping, transporting, and sensing lead to advance next-generation applications including precision medicine, digital nanofluidics, and lab-on-chip systems. This review summarizes the importance and significance of the artificial cilia, delineates the recent progress in artificial cilia-based microfluidics toward microfluidic application, and provides future perspectives. The presented knowledge and insights are envisaged to pave the way for innovative advances for the research communities in miniaturization.
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Hu, Guoqing, and Dongqing Li. "Multiscale phenomena in microfluidics and nanofluidics." Chemical Engineering Science 62, no. 13 (July 2007): 3443–54. http://dx.doi.org/10.1016/j.ces.2006.11.058.

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Sima, Felix, and Koji Sugioka. "Ultrafast laser manufacturing of nanofluidic systems." Nanophotonics 10, no. 9 (June 11, 2021): 2389–406. http://dx.doi.org/10.1515/nanoph-2021-0159.

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Abstract In the last decades, research and development of microfluidics have made extraordinary progress, since they have revolutionized the biological and chemical fields as a backbone of lab-on-a-chip systems. Further advancement pushes to miniaturize the architectures to nanoscale in terms of both the sizes and the fluid dynamics for some specific applications including investigation of biological sub-cellular aspects and chemical analysis with much improved detection limits. In particular, nano-scale channels offer new opportunities for tests at single cell or even molecular levels. Thus, nanofluidics, which is a microfluidic system involving channels with nanometer dimensions typically smaller than several hundred nm, has been proposed as an ideal platform for investigating fundamental molecular events at the cell-extracellular milieu interface, biological sensing, and more recently for studying cancer cell migration in a space much narrower than the cell size. In addition, nanofluidics can be used for sample manipulation in analytical chemistry, such as sample injections, separation, purifications or for quantitative and qualitative determinations. Among the nanofabrication technologies, ultrafast laser manufacturing is a promising tool for fabrication of nanofluidics due to its flexibility, versatility, high fabrication resolution and three dimensional (3D) fabrication capability. In this paper, we review the technological advancements of nanofluidic systems, with emphasis on fabrication methods, in particular ultrafast laser manufacturing. We present the challenges for issues concerning channel sizes and fluid dynamics, and introduce the applications in physics, biology, chemistry and engineering with future prospects.
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Mawatari, Kazuma, Hiroki Koreeda, Koji Ohara, Shinji Kohara, Koji Yoshida, Toshio Yamaguchi, and Takehiko Kitamori. "Nano X-ray diffractometry device for nanofluidics." Lab on a Chip 18, no. 8 (2018): 1259–64. http://dx.doi.org/10.1039/c8lc00077h.

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Cao, Han, Jonas O. Tegenfeldt, Robert H. Austin, and Stephen Y. Chou. "Gradient nanostructures for interfacing microfluidics and nanofluidics." Applied Physics Letters 81, no. 16 (October 14, 2002): 3058–60. http://dx.doi.org/10.1063/1.1515115.

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Morikawa, Kyojiro, Ryoichi Ohta, Kazuma Mawatari, and Takehiko Kitamori. "Metal-Free Fabrication of Fused Silica Extended Nanofluidic Channel to Remove Artifacts in Chemical Analysis." Micromachines 12, no. 8 (July 31, 2021): 917. http://dx.doi.org/10.3390/mi12080917.

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In microfluidics, especially in nanofluidics, nanochannels with functionalized surfaces have recently attracted attention for use as a new tool for the investigation of chemical reaction fields. Molecules handled in the reaction field can reach the single–molecule level due to the small size of the nanochannel. In such surroundings, contamination of the channel surface should be removed at the single–molecule level. In this study, it was assumed that metal materials could contaminate the nanochannels during the fabrication processes; therefore, we aimed to develop metal-free fabrication processes. Fused silica channels 1000 nm-deep were conventionally fabricated using a chromium mask. Instead of chromium, electron beam resists more than 1000 nm thick were used and the lithography conditions were optimized. From the results of optimization, channels with 1000 nm scale width and depth were fabricated on fused silica substrates without the use of a chromium mask. In nanofluidic experiments, an oxidation reaction was observed in a device fabricated by conventional fabrication processes using a chromium mask. It was found that Cr6+ remained on the channel surfaces and reacted with chemicals in the liquid phase in the extended nanochannels; this effect occurred at least to the micromolar level. In contrast, the device fabricated with metal-free processes was free of artifacts induced by the presence of chromium. The developed fabrication processes and results of this study will be a significant contribution to the fundamental technologies employed in the fields of microfluidics and nanofluidics.
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Dissertations / Theses on the topic "Microfluidics and nanofluidics"

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Wang, Shengnian. "Micro-/nanofluidics and single DNA dynamics in non-uniform electrokinetic flows." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1149002340.

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Laohakunakorn, Nadanai. "Electrokinetic phenomena in nanopore transport." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/252690.

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Nanopores are apertures of nanometric dimensions in an insulating matrix. They are routinely used to sense and measure properties of single molecules such as DNA. This sensing technique relies on the process of translocation, whereby a molecule in aqueous solution moves through the pore under an applied electric field. The presence of the molecule modulates the ionic current through the pore, from which information can be obtained regarding the molecule's properties. Whereas the electrical properties of the nanopore are relatively well known, much less work has been done regarding their fluidic properties. In this thesis I investigate the effects of fluid flow within the nanopore system. In particular, the charged nature of the DNA and pore walls results in electrically-driven flows called electroosmosis. Using a setup which combines the nanopore with an optical trap to measure forces with piconewton sensitivity, we elucidate the electroosmotic coupling between multiple DNA molecules inside the confined environment of the pore. Outside the pore, these flows produce a nanofluidic jet, since the pore behaves like a small electroosmotic pump. We show that this jet is well-described by the low Reynolds number limit of the classical Landau-Squire solution of the Navier-Stokes equations. The properties of this jet vary in a complex way with changing conditions: the jet reverses direction as a function of salt concentration, and exhibits asymmetry with respect to voltage reversal. Using a combination of simulations and analytic modelling, we are able to account for all of these effects. The result of this work is a more complete understanding of the fluidic properties of the nanopore. These effects govern the translocation process, and thus have consequences for better control of single molecule sensing. Additionally, the phenomena we have uncovered could potentially be harnessed in novel microfluidic applications, whose technological implications range from lab-on-a-chip devices to personalised medicine.
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Pussadee, Nirut. "Poly(dimethylsiloxane) Based Micro- and Nanofluidic Device Fabrication for Electrophoresis Applications." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1268179904.

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Misiunas, Karolis. "Hydrodynamic interactions in narrow channels." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/286289.

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Particle-particle interactions are of paramount importance in every multi-body system as they determine the collective behaviour and coupling strength. Many well-known interactions like electro-static, van der Waals or screened Coulomb, decay exponentially or with negative powers of the particle spacing r. Similarly, hydrodynamic interactions between particles undergoing Brownian motion decay as 1/r in bulk, and are assumed to decay in small channels. Such interactions are ubiquitous in biological and technological systems. Here I confine multiple particles undergoing Brownian motion in narrow, microfluidic channels and study their coupling through hydrodynamic interactions. Our experiments show that the hydrodynamic particle-particle interactions are distance-independent in these channels. We also show that these interactions affect actively propelled particles via electrophoresis or gravity, resulting in non-linear transport phenomena. These findings are of fundamental importance for understanding transport of dense mixtures of particles or molecules through finite length, water-filled channels or pore networks.
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Kumar, Suresh. "Design, Fabrication, and Optimization of Miniaturized Devices for Bioanalytical Applications." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5979.

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My dissertation work integrates the techniques of microfabrication, micro/nanofluidics, and bioanalytical chemistry to develop miniaturized devices for healthcare applications. Semiconductor processing techniques including photolithography, physical and chemical vapor deposition, and wet etching are used to build these devices in silicon and polymeric materials. On-chip micro-/nanochannels, pumps, and valves are used to manipulate the flow of fluid in these devices. Analytical techniques such as size-based filtration, solid-phase extraction (SPE), sample enrichment, on-chip labeling, microchip electrophoresis (µCE), and laser induced fluorescence (LIF) are utilized to analyze biomolecules. Such miniaturized devices offer the advantages of rapid analysis, low cost, and lab-on-a-chip scale integration that can potentially be used for point-of-care applications.The first project involves construction of sieving devices on a silicon substrate, which can separate sub-100-nm biostructures based on their size. Devices consist of an array of 200 parallel nanochannels with a height step in each channel, an injection reservoir, and a waste reservoir. Height steps are used to sieve the protein mixture based on size as the protein solution flows through channels via capillary action. Proteins smaller than the height step reach the end of the channels while larger proteins stop at the height step, resulting in separation. A process is optimized to fabricate 10-100 nm tall channels with improved reliability and shorter fabrication time. Furthermore, a protocol is developed to reduce the electrostatic interaction between proteins and channel walls, which allows the study of size-selective trapping of five proteins in this system. The effects of protein size and concentration on protein trapping behavior are evaluated. A model is also developed to predict the trapping behavior of different size proteins in these devices. Additionally, the influence of buffer ionic strength, which can change the effective cross-sectional area of nanochannels and trapping of proteins at height steps, is explored in nanochannels. The ionic strength inversely correlates with electric double layer thickness. Overall, this work lays a foundation for developing nanofluidic-based sieving systems with potential applications in lipoprotein fractionation, protein aggregate studies in biopharmaceuticals, and protein preconcentration. The second project focuses on designing and developing a microfluidic-based platform for preterm birth (PTB) diagnosis. PTB is a pregnancy complication that involves delivery before 37 weeks of gestation, and causes many newborn deaths and illnesses worldwide. Several serum PTB biomarkers have recently been identified, including three peptides and six proteins. To provide rapid analysis of these PTB biomarkers, an integrated SPE and µCE device is assembled that provides sample enrichment, on-chip labeling, and separation. The integrated device is a multi-layer structure consisting of polydimethylsiloxane valves with a peristaltic pump, and a porous polymer monolith in a thermoplastic layer. The valves and pump are fabricated using soft lithography to enable pressure-based sample actuation, as an alternative to electrokinetic operation. Porous monolithic columns are synthesized in the SPE unit using UV photopolymerization of a mixture consisting of monomer, cross-linker, photoinitiator, and various porogens. The hydrophobic surface and porous structure of the monolith allow both protein retention and easy flow. I have optimized the conditions for ferritin retention, on-chip labelling, elution, and µCE in a pressure-actuated device. Overall functionality of the integrated device in terms of pressure-controlled flow, protein retention/elution, and on-chip labelling and separation is demonstrated using a PTB biomarker (ferritin). Moreover, I have developed a µCE protocol to separate four PTB biomarkers, including three peptides and one protein. In the future, an immunoaffinity extraction unit will be integrated with SPE and µCE to enable rapid, on-chip analysis of PTB biomarkers. This integrated system can be used to analyze other disease biomarkers as well.
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Chen, Lei. "Electroosmotic Flow and DNA Electrophoretic Transport in Micro/Nano Channels." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1252612019.

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Smith, Ross Andrew. "Biomedical Applications Employing Microfabricated Silicon Nanoporous Membranes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1278705155.

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Yuan, Xichen. "Charges à l’interface liquide/solide : caractérisation par courants d’écoulement et application à la préconcentration de molécules biologiques dans un système micro/nanofluidique." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1214/document.

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Les charges à l'interface liquide/solide sont un élément originel majeur des phénomènes électrocinétiques observés en micro/nanofluidique. Elles sont donc la colonne vertébrale de mon manuscrit de thèse, qui se décompose en trois parties : Dans la première partie, un rappel des concepts de base sur les interfaces liquides/solides est proposé au lecteur. Il est suivi d'une description des différentes méthodes expérimentales permettant de mesurer le potentiel zeta de couples solide/électrolyte, puis d'une présentation des travaux de la littérature exploitant les charges aux interfaces pour la préconcentration de molécules biologiques dans des systèmes Micro-Nano-Micro (MNM) fluidiques. Ensuite, une deuxième partie est consacrée à la mesure du potentiel zeta par la méthode des courants d'écoulement. Nous y présentons l'amélioration du banc expérimental issu des travaux antérieurs à ma thèse, ainsi que le développement de nouveaux protocoles de préparation des surfaces permettant de rationaliser et de stabiliser les mesures. Une application à un détecteur original de molécules biologiques clos cette deuxième partie. Enfin, la troisième et dernière partie s'intéresse à la préconcentration de molécules biologiques. Une méthode originale de fabrication des dispositifs MNM et les résultats de préconcentration obtenus, très encourageants, sont décrits. Des premiers modèles numériques et phénoménologiques sont proposés, qui mettent en avant l'originalité de notre travail
The charges at liquid/solid interfaces are a key element for both understanding and exploiting the electrokinetic phenomena in micro/nanofluidics. The manuscript of my Ph.D thesis is dedicated to these phenomena, which is divided into three main parts: Above all, a simple overview of charges at the liquid/solid interface is proposed. Then, several common methods for measuring the zeta potential at the liquid/solid interface are described. Next, various effective methods to preconcentrate the biological molecules is presented with the help of the surface charges. Secondly, the streaming current, which is a standard method to measure the zeta potential in our laboratory, is detailed. It contains the upgrade of the experimental setup from the previous version and the development of new protocols, which improve dramatically the stabilization and the reproducibility of the measurements. In addition, an original biological sensor is briefly presented based on these advancements. Lastly, in the final part, we describe a method which is primitively utilised in the fabrication of Micro-Nano-Micro fluidic system. Based on this system, some favorable preconcentration results is obtained. Moreover, numerical simulations are presented to prove the originality of our work
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Hamblin, Mark Noble. "Thin Film Microfluidic and Nanofluidic Devices." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2281.

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Lab-on-a-chip devices, also known as micro total analysis systems (μTAS), are implementations of chemical analysis systems on microchips. These systems can be fabricated using standard thin film processing techniques. Microfluidic and nanofluidic channels are fabricated in this work through sacrificial etching. Microchannels are fabricated utilizing cores made from AZ3330 and SU8 photoresist. Multi-channel electroosmotic (EO) pumps are evaluated and the accompanying channel zeta potentials are calculated. Capillary flow is studied as an effective filling mechanism for nanochannels. Experimental departure from the Washburn model is considered, where capillary flow rates lie within 10% to 70% of theoretical values. Nanochannels are fabricated utilizing cores made from aluminum, germanium, and chromium. Nanochannels are made with 5 μm thick top layers of oxide to prevent dynamic channel deformation. Nanochannel separation schemes are considered, including Ogston sieving, entropic trapping, reptation, electrostatic sieving, and immutable trapping. Immutable trapping is studied through dual-segment nanochannels that capture analytes that are too large to pass from one channel into a second, smaller channel. Polymer nanoparticles, Herpes simplex virus type 1 capsids, and hepatitis B virus capsids are trapped and detected. The signal-to-noise ratio of the fluorescently-detected signal is shown to be greater than 3 for all analyte concentrations considered.
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Zhang, Yuxiang, and 张玉相. "Microfluidics: fabrication, droplets, bubblesand nanofluids synthesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44903935.

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Books on the topic "Microfluidics and nanofluidics"

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Kleinstreuer, Clement. Microfluidics and Nanofluidics. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118749890.

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Abgrall, Patrick. Nanofluidics. Boston: Artech House, 2009.

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1970-, Nguyen Nam-Trung, ed. Nanofluidics. Boston: Artech House, 2009.

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Li, Dongqing. Electrokinetic Microfluidics and Nanofluidics. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-16131-5.

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-C, Chang H., ed. Electrokinetically-driven microfluidics and nanofluidics. Cambridge: Cambridge University Press, 2009.

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Li, Dongqing, ed. Encyclopedia of Microfluidics and Nanofluidics. Boston, MA: Springer US, 2013. http://dx.doi.org/10.1007/978-3-642-27758-0.

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Microfluidics and nanofluidics handbook: Fabrication, implementation, and applications. Boca Raton, Fla: CRC Press, 2011.

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Microfluidics and nanofluidics handbook: Chemistry, physics, and life science principles. Roca Raton, FL: CRC Press, 2011.

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Ellero, Marco. IUTAM Symposium on Advances in Micro- and Nanofluidics: Proceedings of the IUTAM Symposium on Advances in Micro- and Nanofluidics, Dresden, Germany, September 6–8, 2007. Dordrecht: Springer Netherlands, 2009.

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Wei na liu kong xin pian shi yan shi. Beijing Shi: Ke xue chu ban she, 2013.

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Book chapters on the topic "Microfluidics and nanofluidics"

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Ducrée, Jens. "Centrifugal Microfluidics." In Encyclopedia of Microfluidics and Nanofluidics, 379–93. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_203.

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Li, Cheuk-Wing, and Mengsu Yang. "Digital Microfluidics." In Encyclopedia of Microfluidics and Nanofluidics, 588–95. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_329.

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Ducrée, Jens. "Centrifugal Microfluidics." In Encyclopedia of Microfluidics and Nanofluidics, 1–18. Boston, MA: Springer US, 2014. http://dx.doi.org/10.1007/978-3-642-27758-0_203-2.

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Li, Cheuk-Wing, and Mengsu Yang. "Digital Microfluidics." In Encyclopedia of Microfluidics and Nanofluidics, 1–8. Boston, MA: Springer US, 2014. http://dx.doi.org/10.1007/978-3-642-27758-0_329-2.

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Li, Dongqing. "Nanofluidic Iontronic Devices." In Electrokinetic Microfluidics and Nanofluidics, 201–46. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-16131-5_6.

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Rangharajan, Kaushik K., and Shaurya Prakash. "Surface-Modified Microfluidics and Nanofluidics." In Encyclopedia of Nanotechnology, 1–7. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-007-6178-0_395-2.

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Rangharajan, Kaushik K., and Shaurya Prakash. "Surface-Modified Microfluidics and Nanofluidics." In Encyclopedia of Nanotechnology, 3997–4002. Dordrecht: Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-017-9780-1_395.

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Zhu, Yimei, Hiromi Inada, Achim Hartschuh, Li Shi, Ada Della Pia, Giovanni Costantini, Amadeo L. Vázquez de Parga, et al. "Surface-Modified Microfluidics and Nanofluidics." In Encyclopedia of Nanotechnology, 2611–15. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-9751-4_395.

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Boybay, Muhammed Said, and Carolyn L. Ren. "Microwave in Microfluidics." In Encyclopedia of Microfluidics and Nanofluidics, 2241–50. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_1781.

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Boybay, Muhammed Said, and Carolyn L. Ren. "Microwave in Microfluidics." In Encyclopedia of Microfluidics and Nanofluidics, 1–12. Boston, MA: Springer US, 2013. http://dx.doi.org/10.1007/978-3-642-27758-0_1781-2.

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Conference papers on the topic "Microfluidics and nanofluidics"

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Han, Jongyoon, and Harold G. Craighead. "From microfluidics to nanofluidics: DNA separation using nanofluidic entropic trap array device." In Micromachining and Microfabrication, edited by Carlos H. Mastrangelo and Holger Becker. SPIE, 2000. http://dx.doi.org/10.1117/12.395654.

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Wei, Jianjun, Hongjun Song, Sameer Singhal, Matthew Kofke, Madu Mendis, and David Waldeck. "An In-Plane Nanofluidic Nanoplasmonics-Based Platform for Biodetection." In ASME 2012 Third International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/mnhmt2012-75206.

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This paper reports a new nanofluidic plasmonics-based sensing platform which can be readily integrated with microfluidics devices, and potentially enable an in-parallel transmission surface plasmon resonance (SPR), lab-on-chip sensing technology. The technology overcomes the current SPR size limitations through a combination of nanofluidics and nanoplasmonics in a rationally designed in-plane nanoslit array capable of concurrent plasmonic sensing and confined-flow for analyte delivery. This work is leveraged on our previous work of using nanoslit metal films for SPR sensing [1, 2], and the in-plane nanofluidic nanoplasmonic platform is different from recently reported nanohole-based nanofluidic plasmonics sensors [3, 4]. The work presented here includes an integrated device with nanofluidic nanoplasmonic arrays interfacing with microfluidic channels, and preliminary findings, from both theoretical and experimental fronts, of the device for bio-sensing.
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Sugioka, Koji, and Felix Sima. "3D glass nanofluidics fabricated by femtosecond laser processing for study on cancer cell metastasis." In Microfluidics, BioMEMS, and Medical Microsystems XIX, edited by Bonnie L. Gray and Holger Becker. SPIE, 2021. http://dx.doi.org/10.1117/12.2590777.

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Wu, Junqing, Gaurav Soni, Dazhi Wang, and Carl D. Meinhart. "AC Electrokinetic Pumps for Micro/NanoFluidics." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-61836.

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We have developed micropumps for microfluidics that use AC electric fields to drive aqueous fluid motion through micro channels. These pumps operate at relatively low voltages (~5–10Vrms), and high frequencies (~100kHz). They have several distinct advantages over the DC electrokinetic pumps. The low voltages make the pumps well suited for a wide variety of biosensor and “Lab-on-a-Chip” applications (e.g. PCR chip for DNA amplification). The high frequencies minimize electrolysis, so that bubbles do not form on the electrode surfaces, and do not contaminate the working fluid. The pumps can also be used as active valves or precision micro-dispensers.
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Kuang, Cuifang, and Guiren Wang. "Fast Nanoscopic Velocimetry for Micro/Nanofluidics." In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18514.

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We presented two kinds of innovative velocimetry with high temporal and spatial resolution respectively based on the Laser Induced Fluorescence Photobleaching Anemometer (LIFPA) and Stimulated Emission Depletion (STED) techniques. The temporal and spatial resolution has been for the first time achieved to 5–10 μs and 70 nm, respectively. To our knowledge, the temporal resolution is about 100× better than that of the state of the art microPIV, which is currently the most widely used velocimetry in microfluidics community. And for the first time, flow velocity distribution in a nanocapillary has been measured with a spatial resolution better than 70 nm.
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Bohn, P., S. P. Branagan, and N. Contento. "METALS IN MICROFLUIDICS - COUPLING PLASMONICS, ELECTRON TRANSFER AND NANOFLUIDICS IN A MONOLITHIC STRUCTURE." In 2010 Solid-State, Actuators, and Microsystems Workshop. San Diego: Transducer Research Foundation, 2010. http://dx.doi.org/10.31438/trf.hh2010.8.

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7

Woeste, Jacob T., Mark G. Turner, and Nicolas Saxer. "Erratum: “A Hydrofoil Configuration for Wind Powered Energy Ship Applications” [ASME 2017 Fluids Engineering Division Summer Meeting, Volume 1B, Symposia: Fluid Measurement and Instrumentation; Fluid Dynamics of Wind Energy; Renewable and Sustainable Energy Conversion; Energy and Process Engineering; Microfluidics and Nanofluidics; Development and Applications in Computational Fluid Dynamics; DNS/LES and Hybrid RANS/LES Methods, Waikoloa, Hawaii, USA, July 30–August 3, 2017, Conference Sponsors: Fluids Engineering Division, ISBN: 978-0-7918-5805-9, Copyright © 2017 by ASME. Paper No. FEDSM2017-69402, pp. V01BT07A003; 10 pages; doi:10.1115/FEDSM2017-69402]." In ASME 2017 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/fedsm2017-69402e.

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This erratum corrects errors that appeared in the paper “A Hydrofoil Configuration for Wind Powered Energy Ship Applications” which was published in Proceedings of the ASME 2017 Fluids Engineering Division Summer Meeting, Volume 1B, Symposia: Fluid Measurement and Instrumentation; Fluid Dynamics of Wind Energy; Renewable and Sustainable Energy Conversion; Energy and Process Engineering; Microfluidics and Nanofluidics; Development and Applications in Computational Fluid Dynamics; DNS/LES and Hybrid RANS/LES Methods, V01BT07A003, July 2017, FEDSM2017-69402, doi: 10.1115/FEDSM2017-69402.
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8

Pawar, Gorakh, Ilija Miskovic, and Manjunath Basavarajappa. "Evaluation of Fluid Behaviour and Mixing Efficiency in Predefined Serpentine Micro-Fracture System." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-65124.

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Scientific research and development in the field of microfluidics and nanofluidics technology has witnessed a rapid expansion in recent years. Microfluidic and nanofluidic systems are finding increasing application in wide spectrum of biomedical and engineering fields, including oil and gas technology. Fluid flow characterization in porous geologic media is an important factor for predicting and improving oil and gas recovery. By developing understanding about the propagation of hydraulic fracturing fluid constituents in irregular micro- and nano-structures, and their multiphase interaction with reservoir fluids (e.g. mixing of supercritical CO2 with oil or gas) we can significantly improve efficiency of the current oil and gas (O&G) extraction process and reduce associated environmental impacts. In present paper, mixing of hydraulic fracturing fluid constituents in three dimensional serpentine microchannel system is simulated in CFD environment and results are used to evaluate mixing efficiency for different fracturing fluid compositions. In addition, pressure drop along the length of serpentine micro-channel is evaluated. Serpentine micro-channels considered in this study consist of periodic symmetrical and asymmetrical proppant particles, placed on both sides of the channel over the full length of the channel, to simulate realistic geometrical constraints usually seen in geological fractures. The fluid flow is characterized as a function of the proppant particle radius by varying size of adjacent proppant particles. Further, the flow is characterized by varying distance between adjacent proppant particles. Overall, this study will be primarily helpful to gain fundamental understanding of fracturing fluid mixing in micro-fractures, similar to real geologic media. In addition, this study will provide an insight into variations of fracturing fluid mixing efficiency, and pressure drop in micro-fracture systems as a function of geometry of the proppant particles at different flow rates.
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Takayama, Shuichi, Yi-Chung Tung, and Bor-Han Chueh. "Biological Micro/Nanofluidics." In ASME 2008 First International Conference on Micro/Nanoscale Heat Transfer. ASMEDC, 2008. http://dx.doi.org/10.1115/mnht2008-52087.

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Many biological studies, drug screening methods, and cellular therapies require culture and manipulation of living cells outside of their natural environment in the body. The gap between the cellular microenvironment in vivo and in vitro, however, poses challenges for obtaining physiologically relevant responses from cells used in basic biological studies or drug screens and for drawing out the maximum functional potential from cells used therapeutically. One of the reasons for this gap is because the fluidic environment of mammalian cells in vivo is microscale and dynamic whereas typical in vitro cultures are macroscopic and static. This presentation will give an overview of efforts in our laboratory to develop programmable microfluidic systems that enable spatio-temporal control of both the chemical and fluid mechanical environment of cells. The technologies and methods close the physiology gap to provide biological information otherwise unobtainable and to enhance cellular performance in therapeutic applications. Specific biomedical topics that will be discussed include subcellular signalling in normal and cancer cells, in vitro fertilization on a chip, studies of the effect of physiological and pathological fluid mechanical stresses on endothelial and epithelial cells, and microfluidic stem cell engineering. In the nanoscale regime, tunable nanochannels that can manipulate single DNA molecules will be discussed.
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Nguyen, Nam-Trung, S. M. Sohel Murshed, and Say-Hwa Tan. "Investigation of Temperature-Dependent Droplet Formation of Nanofluids in Microfluidic T-Junction." In 2008 Second International Conference on Integration and Commercialization of Micro and Nanosystems. ASMEDC, 2008. http://dx.doi.org/10.1115/micronano2008-70268.

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The study on the control of microdroplet formation and manipulation is very important due to the potential applications of droplet-based microfluidics in various important fields. Experimental investigations on thermally controlled droplet formation and size manipulation of deionized water and nanofluids in a microfluidic T-junction are reported in this paper. The heater temperature affects the droplet formation process. Nanofluids are found to exhibit different characteristics in droplet formation and size control with the temperature. Addition of spherical-shaped TiO2 (15 nm) nanoparticles in deionized water results in much smaller droplet size compared to the cylindrical-shaped TiO2 (10×40) nm) nanoparticles. Other than nanofluid with cylindrical-shaped nanoparticles, the droplet size was found to increase with increasing temperature.
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